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1

Pereira, Morais Marta. "Biophysical analysis of glycated proteins." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547628.

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2

Dale, Michael Anthony Joseph. "Global Energy Modelling : A Biophysical Approach (GEMBA)." Thesis, University of Canterbury. Mechanical Engineering, 2010. http://hdl.handle.net/10092/5156.

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The aim of this thesis is to take a broad conceptual overview of the global energy system and investigate what the aims of sustainability might entail for such a system. The work presented uses a biophysical economic approach in that the dynamics of the global economy are investigated using the tool box of the physical sciences, including the laws of thermodynamics and the methods of energy analysis. Modern society currently uses approximately 500 exajoules (EJ = 10^18 J) of total primary energy supply (TPES) each year. This energy consumption has been increasing at roughly 2% per
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3

Seldeen, Kenneth Ladd. "Biophysical Analysis of the AP1-DNA Interaction." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/259.

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Jun and Fos are components of the AP1 family of transcription factors that bind to the promoters of a diverse multitude of genes involved in critical cellular responses such as cell growth and proliferation, cell cycle regulation, embryonic development and cancer. The specific protein-DNA interactions are driven by the binding of basic zipper (bZIP) domains of Jun and Fos to TPA response element (TRE) and cAMP response element (CRE) within the promoters of target genes. Here, using a diverse array of biophysical techniques, including in particular isothermal titration calorimetry in conjuncti
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4

Jiang, Hai. "Quantitative deformable motion estimation for biophysical analysis /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3144427.

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5

Uno, Masatoshi. "Biophysical analysis of MyD88 and related proteins." Kyoto University, 2019. http://hdl.handle.net/2433/242528.

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付記する学位プログラム名: 充実した健康長寿社会を築く総合医療開発リーダー育成プログラム<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第21790号<br>工博第4607号<br>新制||工||1718(附属図書館)<br>京都大学大学院工学研究科分子工学専攻<br>(主査)教授 白川 昌宏, 教授 梶 弘典, 教授 森 泰生<br>学位規則第4条第1項該当
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6

Higham, Richard G. "A biophysical analysis of the Ocr protein gel." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/2569.

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Ocr is unusual among proteins in its ability to form a transparent gel at high ammonium sulphate concentrations. This transition was investigated using a combination of spectroscopic, microscopic and rheological techniques. It occurs sharply at a concentration of 3.2M ammonium sulphate and is not observed with other types of salt. Rheological measurements showed that rather than precipitating under such conditions, ocr forms a weak viscoelastic gel. Far UV circular dichroism spectra reveal that ocr does not denature in the gel phase, while near UV CD spectra suggest the formation of long, heli
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7

Vaillancourt, Benoit. "Novel biophysical appliations [sic] of STICS." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111550.

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The object of this thesis is to present two novel applications of Spatiotemporal Image Correlation Spectroscopy (STICS) to biological systems. STICS is a technique which uses the correlations in pixel intensity fluctuations of an image time series, captured under fluorescence microscopy, to measure the speed and direction of a flowing population of fluorescently labeled molecules. The method was first applied to measure the dynamics of transport vesicles inside growing pollen tubes of lily flowers. The measured vector maps allowed to confirm the presence of actin filaments along the periphery
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8

Massis, Sameer. "Biophysical studies and thermodynamic analysis of cathepsin B interactions." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21606.

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The aim of this project was to study the binding of a series of truncated forms of the propeptide to rat cathepsin B. This was done previously by using enzyme inhibition assays (Chen et al, 1996), in which binding is detectable only for those peptides that bind to the catalytic site, and hence compete with the substrate for that site. For this reason, Isothermal Titration Calorimetry (ITC) was utilised since heat detection provides a more direct measurement of binding, irrespective of its location on the enzyme. However, several difficulties were encountered which rendered this approach less f
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9

Massis, Sameer. "Biophysical studies and thermodynamic analysis of cathepsin B interactions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0026/MQ50833.pdf.

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10

Kirby, Ian. "Molecular and biophysical analysis of adenoviral fiber-receptor interactions." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429491.

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11

Chemla, Sandrine. "A biophysical cortical column model for optical signal analysis." Nice, 2010. http://www.theses.fr/2010NICE4004.

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L'imagerie optique extrinsèque basée sur l'utilisation de colorants sensibles aux potentiels (VSD) est actuellement la seule technique de neuroimagerie offrant la possibilité d'observer l'activité d'une large population de neurones avec une forte résolution spatiale et temporelle. Dans cette thèse, notre but est d'étudier les origines biologiques du signal d'imagerie optique (signal VSD), étant donné que cette question reste sans réponse claire dans littérature. Identifier l'origine du signal VSD est difficile au niveau physiologique car les molécules de colorant reflètent la dynamique du pote
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12

Valba, Olga. "Statistical analysis of networks and biophysical systems of complex architecture." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00919606.

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Complex organization is found in many biological systems. For example, biopolymers could possess very hierarchic structure, which provides their functional peculiarity. Understating such, complex organization allows describing biological phenomena and predicting molecule functions. Besides, we can try to characterize the specific phenomenon by some probabilistic quantities (variances, means, etc), assuming the primary biopolymer structure to be randomly formed according to some statistical distribution. Such a formulation is oriented toward evolutionary problems.Artificially constructed biolog
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13

Doko, Denisa. "Biophysical characterization and NMR analysis of the PDI fragment b'xa'c." Thesis, University of Kent, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595792.

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Protein disulphide isomerase (PDI) was the first catalyst of protein folding to be identified and is a key cellular chaperone required for the rapid formation of correctly folded disulphide bonded proteins in the secretory pathway. PDI is the archetype of a large family of ER-resident PDI-like proteins and contains four thioredoxin-like domains, two of which, like thioredoxin itself, have redox-active (COHC) catalytic sites (a and a') and two of which do not (b and b'). The domain order is abb'xa'c where x is a 19 residue linker between the b' and a' domains and c is a C-terminal acidic tail c
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14

Holley, Tracey. "Biophysical analysis of MarR family transcription factors from Streptomyces coelicolor." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42332/.

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Streptomycetes represent a rich source of potentially useful therapeutics. However, in a laboratory environment, a large proportion of their secondary metabolite gene clusters remain silent, and thus their full metabolic potential is not realised. One way to unlock these so-called "cryptic" clusters may be to manipulate specific regulatory proteins. But, the vast majority of these regulators are uncharacterized, making it difficult to do this in a rational way. The MarR family of regulatory proteins (MFRs) represents an important group of transcriptional regulators. Named after the first to be
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15

Keeble, Anthony Howard. "Biophysical analysis of ligand binding to the colicin E9 endonuclease." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251393.

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16

Hilton, D. W. "Elucidating the aggregation mechanisms of antibody fragments through biophysical analysis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1492898/.

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The spontaneous formation of aggregates presents an obstacle in the developability, manufacturability and long term storage of numerous therapeutic proteins. These aggregates are a manifestation of the drug molecule's physical instability, potentially leading to reduced biological activity, differences in solution properties or increased immunogenic potential. Currently our understanding of the mechanisms behind aggregation and the role of a protein's extrinsic environment upon the molecule's aggregation propensity remains limited. In this study we investigated the aggregation behavior of a pr
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17

Sakaguchi, Ronald L. "A biophysical analysis of the occlusal wear of dental materials." Thesis, University of Greenwich, 1988. http://gala.gre.ac.uk/8245/.

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An artificial oral environment was used to clinically simulate the dental wear process and surface friction between opposing maxillary and mandibular elements. Measurement of surface friction between occlusal surfaces of natural premolar teeth demonstrated large variation. High viscosity lubricants and surfactant containing lubricants were capable of reducing the surface friction. The enamel appeared otherwise insensitive to natural and artificial salivary fluids. Orientation of opposing enamel prisms was critical for reduction of interocclusal friction. A critical choice of prosthetic dental
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18

Graybill, Christopher A. "Biophysical Analysis of the Human Erythrocyte Glucose Transporter: a Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/207.

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Hydrodynamic analysis and electron microscopy of GLUT1/lipid/detergent micelles and freeze fracture electron microscopy of GLUT1 proteoliposomes support the hypothesis that the glucose transporter is a multimeric (probably tetrameric) complex of GLUT1 proteins. Some detergents (e.g. octylglucoside) maintain the multimeric complex while other detergents (e.g. CHAPS and dodecylmaltoside) promote the dissociation of GLUT1 oligomers into smaller aggregation states (dimers or monomers). GLUT1 does not appear to exchange rapidly between protein/lipid/detergent micelles but is able to self-associate
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19

Wright, Thaiesha Andrea. "Advances in Synthesis and Biophysical Analysis of Protein-Polymer Bioconjugates." Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1593472633914607.

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20

Graybill, Christopher A. "Biophysical Analysis of the Human Erythrocyte Glucose Transporter: a Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/207.

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Hydrodynamic analysis and electron microscopy of GLUT1/lipid/detergent micelles and freeze fracture electron microscopy of GLUT1 proteoliposomes support the hypothesis that the glucose transporter is a multimeric (probably tetrameric) complex of GLUT1 proteins. Some detergents (e.g. octylglucoside) maintain the multimeric complex while other detergents (e.g. CHAPS and dodecylmaltoside) promote the dissociation of GLUT1 oligomers into smaller aggregation states (dimers or monomers). GLUT1 does not appear to exchange rapidly between protein/lipid/detergent micelles but is able to self-associate
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21

Donovan, Alexandra. "Comparative Biophysical Analysis of APOE3 and APOE4| A Mechanistic Investigation." Thesis, California State University, Long Beach, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10606132.

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<p> Apolipoprotein E is an exchangeable apolipoprotein whose isoforms are associated with various disease risk profiles. Individuals bearing the <i> APOE</i> &epsiv;4 allele are at increased risk for developing Alzheimer&rsquo;s disease compared to those bearing the <i>APOE</i> &epsiv;3 allele. The two isoforms differ in amino acid at position 112: apoE3 bears a Cys while apoE4 bears an Arg. It is hypothesized that the Cys to Arg substitution in apoE4 causes a decrease in stability in comparison to apoE3, which is exaggerated at endosomal pH &lt;6.0. In our study, changes in secondary structur
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22

Clayton, Amber Jayne. "Structural, biophysical and cellular analysis of synaptic receptors and organizers." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:86579b80-d0de-4f69-a247-b9753882abca.

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23

Harman, Michael William. "The Biophysical Mechanisms Of Bacterial And Cellular Invasion." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/595820.

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Advances in genetics and fluorescent protein chemistry have enabled us to fuse fluorescent probes directly to biomolecules in stably growing organisms; making it easier to image the precise position and movement of cells in three dimensions. Fluorescent stains and dyes can be employed in a similar fashion to visualize nano-scale fluctuations in active cellular structures without fixation. While informative and exciting on a qualitatively level, microscopy truly becomes powerful when we can extract meaningful quantitative information. To accomplish this, custom MATLAB (Mathworks, Natick, MA) im
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24

Isaksson, Mikael. "On the quantitative analysis of electronic energy transfer/migration in proteins studied by fluorescence spectroscopy." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1009.

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25

Gehlen, Lutz Robert. "Biophysical analysis of diffusion controlled processes in the budding yeast nucleus /." [S.l.] : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8860.

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26

Wu, Xiaoqiu. "Functional genomics at the interface of protein expression and biophysical analysis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-772-X.

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27

Kreusel, Katja Martina. "Construction of a novel IgG4 antibody and its subsequent biophysical analysis." Thesis, University of London, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385286.

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28

Halebian, Mary. "Biophysical analysis of binding interactions between clathrin and its adaptor proteins." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/101061/.

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Clathrin-mediated endocytosis (CME) plays a central role in fundamental processes such as synaptic vesicle recycling, receptor recycling, signalling and development. CME begins with clathrin assembly on the plasma membrane, facilitated by adaptor proteins. This process forms an endocytic vesicle that allows transport of cargo into the cell, and is followed by clathrin disassembly through the action of different adaptor/accessory proteins. A large number of different adaptor and accessory proteins are recruited during CME, in a spatially and temporally ordered manner. Although our understanding
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29

Sawyer, Elizabeth Bryony. "Biophysical analysis of haem-protein interactions in bacterial haem transfer systems." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611709.

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30

Henkin, Michael Albert. "A Biophysical Analysis of Forest Diversity Patterns at Mt. Kasigau, Kenya." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1376397960.

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31

Šmít, Daniel. "Analysis of dynamical interactions of axon shafts and their biophysical modelling." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066095/document.

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La fasciculation des axones joue un rôle essentiel dans le développement des réseaux neuronaux. Cependant, la dynamique de la fasciculation axonale, ainsi que les mécanismes biophysiques à l’œuvre dans ce processus, demeurent encore très mal compris. En vue d'étudier les mécanismes de fasciculation d'axones ex vivo, nous avons développé un système modèle simple, constitué par des explants d'épithélium olfactif de souris embryonnaires en culture, à partir desquels poussent les axones des neurones sensoriels olfactifs. Grâce à une étude en vidéomicroscopie, nous avons observé que ces axones inte
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32

Alomari, Arqam. "Biophysical and kinetic analysis of Escherichia coli DNA ligase activity and inhibition." Thesis, University of Portsmouth, 2018. https://researchportal.port.ac.uk/portal/en/theses/biophysical-and-kinetic-analysis-of-escherichia-coli-dna-ligase-activity-and-inhibition(96c7d355-6dbe-4e2a-be0d-5641ec98e54a).html.

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DNA ligases are essential enzymes across all three domains of life. Their role is to bind nicked DNA or DNA ends and re-join broken nucleic acid strands. In bacteria, there are two key pathways that DNA ligases are involved in: DNA replication during cell division and DNA repair for breaks in DNA that occur as a result of damage. In E.coli, there are two genes for DNA ligases: LigA, whose structure has been published and LigB as a second ligase (unknown in structure) that has a different DNA, and therefore protein, sequence. The overall aim of this work was first to clone, express, purify and
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33

Newman, Emily Rebekah. "Biophysical analysis of the Nucleosome Assembly Protein and its interaction with histones." Thesis, University of Portsmouth, 2011. https://researchportal.port.ac.uk/portal/en/theses/biophysical-analysis-of-the-nucleosome-assembly-protein-and-its-interaction-with-histones(377df30b-78d9-4880-8820-ae971111b287).html.

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Eukaryotic DNA must undergo high levels of compaction with a complex topology to package the entire genome into the relatively small nucleus. Exquisitely controlled, local de-compaction of the DNA is also essential for fundamental cellular processes such as DNA replication and transcription. An understanding of the biological and structural nature of these processes is central to unravelling how cellular life is regulated. The primary level of compaction involves the double stranded DNA wrapping around a core of histone proteins, two each of the H2A/H2B and H3/H4 dimers, to form the nucleosome
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34

Albertoni, Barbara [Verfasser]. "Biophysical analysis of protein-protein and protein-small molecule interactions / Barbara Albertoni." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1044846909/34.

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35

McDevitt, Christopher A. "The molecular analysis and biophysical characterisation of DMS dehydrogenase from Rhodovulum sulfidophilum /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16102.pdf.

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36

Paguio, Michelle Fortaleza. "Biochemical and biophysical analysis of recombinant Plasmodium falciparum chloroquine resistance transporter (pfcrt)." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/525210083/viewonline.

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37

Yee, Ai Woon. "Towards an understanding of amyloidogenesis : a structural and biophysical analysis of transthyretin." Thesis, Keele University, 2018. http://eprints.keele.ac.uk/4535/.

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Human transthyretin (TTR) is heavily implicated in a range of fatal amyloid diseases. The propensity to form amyloid varies between wild-type TTR and various mutants. In all cases this occurs by tetramer dissociation to a monomeric form, which in turn polymerises into intermediates that ultimately assemble into amyloid fibrils. Numerous X-ray crystal structures of TTR mutants have been determined over the last 40 years. These structures have all turned out to be very similar, shedding little light on the widely varying amyloid-forming properties. The goal of this PhD project was to investigate
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38

Rohr, Tyler W. "Computational analysis of the biophysical controls on Southern Ocean phytoplankton ecosystem dynamics." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122325.

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Thesis: Ph. D., Joint Program in Oceanography/Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Department of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 193-220).<br>Southern Ocean net community productivity plays an out sized role in regulating global biogeochemical cycling and climate dynamics. The structure of spatial-temporal variability in phytoplankton ecosystem dynamics is largely governed by physical processes but a vari
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39

Guthrie, Kevin Mark. "Biophysical analysis of interaction of dihydro-imidazo-phenanthridinium based compounds with DNA." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486740.

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The interaction of small molecules with DNA is an area ofresearch which is important to several fields, for example in anti-cancer and anti-viral drug design. However, the physical processes behind such molecular associations and their resultant biological activity are unclear. A thorough understanding ofthe underlying thermodynamics which govern such binding processes will aid in the design ofnew DNA binding ligands with enhanced properties. In this thesis the DNA binding properties ofa new class ofpotential intercalating agents, the dihydro-imidazo-phenathridinium (DIP) ligands, are discusse
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40

Chasse, Scott Andrew. "The production, biophysical characterization, and crystallization of the human 8-oxo-deoxyguanosine triphosphate pyrophosphohydrolase, MTH1." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/29837.

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41

Lowes, Vicki L. "Molecular and biophysical analysis of the delayed rectifier K+ current in bullfrog atrium." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34684.pdf.

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42

Park, Alison. "Biophysical and kinetic analysis of enzymes comprising the related shikimate and quinate pathways." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402411.

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43

Mayer, Jürgen. "Investigation of the biophysical basis for cell organelle morphology." Master's thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-26600.

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It is known that fission yeast Schizosaccharomyces pombe maintains its nuclear envelope during mitosis and it undergoes an interesting shape change during cell division - from a spherical via an ellipsoidal and a peanut-like to a dumb-bell shape. However, the biomechanical system behind this amazing transformation is still not understood. What we know is, that the shape must change due to forces acting on the membrane surrounding the nucleus and the microtubule based mitotic spindle is thought to play a key role. To estimate the locations and directions of the forces, the shape of the nucleus
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44

Mayer, Jürgen. "Investigation of the biophysical basis for cell organelle morphology." Master's thesis, Max-Planck-Institut für Molekulare Zellbiologie und Genetik, 2008. https://tud.qucosa.de/id/qucosa%3A25225.

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It is known that fission yeast Schizosaccharomyces pombe maintains its nuclear envelope during mitosis and it undergoes an interesting shape change during cell division - from a spherical via an ellipsoidal and a peanut-like to a dumb-bell shape. However, the biomechanical system behind this amazing transformation is still not understood. What we know is, that the shape must change due to forces acting on the membrane surrounding the nucleus and the microtubule based mitotic spindle is thought to play a key role. To estimate the locations and directions of the forces, the shape of the nucleus
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45

van, Leeuwen Willem Jan Dirk 1961. "Biophysical interpretation of spectral indices for semi-arid soil and vegetation types in Niger." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/191193.

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In situ radiometric field data and data simulated with a radiative transfer model were used to evaluate the performance and biophysical interpretation of spectral indices Concurrently with remotely sensed measurements, temporal biophysical measurements for different vegetation types for two semi-arid regions in Niger were made, including leaf area index (LAI), fraction of absorbed photosynthetically active radiation (fAPAR), percent vegetation cover, and biomass. The spectral dynamics of vegetation and soil were characterized at the leaf and canopy scale by optical measurements under many adve
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46

Pursglove, Sharon Elizabeth. "Biophysical analysis of Tec Kinase regulatory regions : implications for the control of Kinase activity." Title page, contents and summary only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09php9863.pdf.

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47

Taylor, Samantha Louise. "Biophysical analysis and nuclear magnetic resonance spectroscopy of CobR and vitamin B12 pathway intermediates." Thesis, University of Kent, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.591917.

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Vitamin B 12 (cobalamin) is of key medical and commercial importance. It is one of the eight B vitamins that are only produced by prokaryotes, but required in the diet by humans. It primarily affects DNA synthesis and regulation, but is also involved in fany acid synthesis and energy production. Deficiencies in cobalamin can lead to anaemia, sensory or motor deficiencies, fatigue, depression, dementia and other psychiatric problems. Commercially over 10 tonnes of cobalamin are produced every year, therefore understanding the pathway to make the process cost efficient is of significant importan
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48

Rivers, Robert Clay. "Biophysical analysis of the aggregation behaviour and structural properties of α- and β-synuclein". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612821.

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49

Bruzas, Ian R. "Biocompatible noble metal nanoparticle substrates for bioanalytical and biophysical analysis of protein and lipids." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553250462519941.

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50

Rana, Sandeep. "Synthesis, biophysical analysis and biological evaluation of trycyclic pyrones and pyridinones as anti-alzheimer agents." Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/1732.

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