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Relevant bibliographies by topics / Biophysical modelling / Dissertations / Theses

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Dissertations / Theses on the topic 'Biophysical modelling'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Lorz, Alexander Stephan Richard. "Partial differential equations modelling biophysical phenomena." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609381.

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2

CARANTE, MARIO PIETRO. "Biophysical modelling for cancer ion therapy." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203385.

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3

Padarian, Campusano José Sergei. "Provision of soil information for biophysical modelling." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12278.

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This thesis is concerned with the generation of a framework for addressing soil data needs, specifically for biophysical modelling. The soil system is an important ecosystem actor, supporting most of the worlds' food production and being the major terrestrial carbon stocks, thereby information about it is crucial for management and policy making. To provide this information, it is important to deliver information of the highest possible quality; thus the need to define guidelines to standardise, not only the methodologies, but the minimum requirements that information must meet. In this proje

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4

Dale, Michael Anthony Joseph. "Global Energy Modelling : A Biophysical Approach (GEMBA)." Thesis, University of Canterbury. Mechanical Engineering, 2010. http://hdl.handle.net/10092/5156.

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The aim of this thesis is to take a broad conceptual overview of the global energy system and investigate what the aims of sustainability might entail for such a system. The work presented uses a biophysical economic approach in that the dynamics of the global economy are investigated using the tool box of the physical sciences, including the laws of thermodynamics and the methods of energy analysis. Modern society currently uses approximately 500 exajoules (EJ = 10^18 J) of total primary energy supply (TPES) each year. This energy consumption has been increasing at roughly 2% per

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5

Lowe, Martin. "Modelling landfill as a complex biophysical technology." Thesis, Cranfield University, 1998. http://dspace.lib.cranfield.ac.uk/handle/1826/10637.

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Concerns regarding climate change are becoming a driver behind legislation at both UK and EU levels, and also on the wider, planetary scale This is the case with emissions from landfills where the release of methane is being targeted for reduction This thesis uses an integrative approach, incorporating concepts of hierarchy from systems theory, to model landfill as a complex biophysical technology It assesses the contribution to carbon deposition and global warming of landfill through changes to that technology itself and through changes in the waste stream caused by potential waste policies T

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6

TELLO, CAJIAO JOHN JAMES. "Biophysical modelling of radiation-induced chromosome aberrations." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1291026.

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7

Hanlon, Michael Richard. "Molecular modelling and biophysical characterisation of three proteins." Thesis, Birkbeck (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326154.

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8

Berardi, Andrea. "Biophysical modelling of the Astroni Nature Reserve, Naples, Italy." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321946.

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9

Kragt, Marit Ellen. "An integrated assessment approach to linking biophysical modelling and economic valuation." Phd thesis, Canberra, ACT : The Australian National University, 2010. http://hdl.handle.net/1885/8037.

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Changes to land use and land management in Australian catchments have led to pressures on natural resources, and concerns over water quality and ecosystem health in catchment rivers and estuaries. To increase the efficiency of natural resource management (NRM) policies that address these concerns, decision makers require information about the environmental impacts, as well as the marginal costs and benefits associated with policy decisions. Including cost-benefits estimates in NRM policy assessment provides decision makers with economic information about the trade-offs between alternative NRM

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10

Šmít, Daniel. "Analysis of dynamical interactions of axon shafts and their biophysical modelling." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066095/document.

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La fasciculation des axones joue un rôle essentiel dans le développement des réseaux neuronaux. Cependant, la dynamique de la fasciculation axonale, ainsi que les mécanismes biophysiques à l’œuvre dans ce processus, demeurent encore très mal compris. En vue d'étudier les mécanismes de fasciculation d'axones ex vivo, nous avons développé un système modèle simple, constitué par des explants d'épithélium olfactif de souris embryonnaires en culture, à partir desquels poussent les axones des neurones sensoriels olfactifs. Grâce à une étude en vidéomicroscopie, nous avons observé que ces axones inte

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11

Tao, Tao. "Biophysical Modelling of the Genesis of Alternans inCardiac Intracellular Ca2+ Handling." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504742.

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Cardiac mechanical alternans are believed to be associated with intracellular Ca2 + alternans. However, the mechanisms underlying the genesis of intracellular Ca2 + alternans are unclear. Experimental studies have shown that alternans of systolic Ca2 + under voltage clamp can be produced either by partially inhibiting the Ca2+ release mechanism or by applying small depolarising pulses. In each case the alternans relied on the appearance of propagating waves of Ca2 + release. The aim of the work in this thesis is to develop a theoretical model to understand the mechanisms underlying how the bea

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12

Janoutová, Růžena. "Modelling 3D Forest Structure for Improved Retrieval of Forest Biophysical Properties." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-263358.

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Hlavním cílem práce bylo zlepšení kvantitativních odhadů vegetačních parametrů smrkových porostů pomocí spektrálních simulací trojrozměrného modelu přenosu záření. Prvně bylo potřeba vytvořit přesný 3D model smrku. Implementace přesného 3D modelu smrku pro parametrizaci celých lesních porostů je v současné době výpočetně nemožné, bylo tedy nutné tento 3D model smrku zjednodušit. Přesný 3D model smrku společně s dostupnými leteckými daty sloužil pro nalezení optimálního zjednodušení. Optimální model vedl ke kompromisu mezi výpočetní náročností a přesností výsledné odrazivosti z modelu přenosu z

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13

Howells, James Anthony. "Biophysical Determinants of the Behaviour of Human Myelinated Axons." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10268.

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This thesis investigates the role of the hyperpolarization-activated current, Ih, on the excitability of human axons. It exploits the unique characteristics of the underlying hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels to improve existing and create new techniques for studying Ih. An isolated amplifier with low-noise and high common-mode rejection was developed, and threshold tracking techniques were modified to allow the measurement of the excitability of low-threshold sensory axons and of cutaneous afferents close to their receptors. These developments open up the p

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14

Valentine, Ronan. "Biophysical aspects of photodynamic therapy." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2471.

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Photodynamic therapy (PDT) is a multimodality cancer treatment available for the palliation or eradication of systemic and cutaneous malignancies. In this thesis, the application of PDT is for the treatment of non-melanoma skin cancer (NMSC). While PDT has a well-documented track record, there are, at this time no significant indicators to suggest the superiority of one treatment regime over the next. The motivation for this work is to provide additional evidence pertaining to PDT treatment variables, and to assist in optimising PDT treatment regimes. One such variable is the treatment light d

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15

Piechnik, Stefan K. "A mathematical and biophysical modelling of cerebral blood flow and cerebrospinal fluid dynamics." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269226.

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16

Talathi, Sachin S. "Biophysical modelling of synaptic plasticity and its function in the dynamics of neuronal networks." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3214710.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed July 10, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 147-155).

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17

Ni, Haibo. "Biophysical modelling of functional impacts of potassium channel mutations on human atrial and ventricular dynamics." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/biophysical-modelling-of-functional-impacts-of-potassium-channel-mutations-on-human-atrial-and-ventricular-dynamics(3372fd6a-850b-4f7d-893a-e2da28269ba8).html.

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Atrial fibrillation (AF) is the most common cardiac arrhythmia causing morbidity and mortality. Despite recent advances, developing effective and safe anti-AF pharmaceutical therapies remains challenging and is prone to adverse effects in the ventricles. Atrial-selective therapies are promising in managing AF. A better understanding of the role of the atrial-specific ion channels in the atrial arrhythmogenesis and contractility, as well as the anti-AF effects of blocking these channels is of interests. Also, a 3D ventricle-torso model capable of modelling ventricular electrical activities and

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18

Khanna, Neha, and Neha Khanna@mdbc gov au. "Investigation of phytoplankton dynamics using time-series analysis of biophysical parameters in Gippsland Lakes, South-eastern Australia." RMIT University. Civil, Environmental and Chemical Engineering, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080226.123435.

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There is a need for ecological modelling to help understand the dynamics in ecological systems, and thus aid management decisions to maintain or improve the quality of the ecological systems. This research focuses on non linear statistical modelling of observations from an estuarine system, Gippsland Lakes, on the south-eastern coast of Australia. Feed forward neural networks are used to model chlorophyll time series from a fixed monitoring station at Point King. The research proposes a systematic approach to modelling in ecology using feed forward neural networks, to ensure: (a) that res

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19

Hall, Zoe Lauren. "Protein complexes in the gas phase : structural insights from ion mobility-mass spectrometry and computational modelling." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:a958f616-e37f-42e2-bf57-a38d58388b0c.

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Structure determination of macromolecular protein assemblies remains a challenge for well-established experimental methods. In this thesis, an emerging structural technique, ion mobility-mass spectrometry (IM-MS) is explored. An assessment of collision cross section (CCS) measurement accuracy using travelling-wave IM (TWIMS) instrumentation was carried out (Chapter 3). Through the collation of a protein complex CCS database and the development of a calibration framework for TWIMS, significant improvements to CCS measurement accuracy have been achieved. Next, the advantages and limitations of u

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20

Sulieman, Hussein Mohamed. "Mapping and Modelling of Vegetation Changes in the Southern Gadarif Region, Sudan, Using Remote Sensing: Land-Use Impacts on Biophysical Processes." Doctoral thesis, Dresden TUDpress, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=3058481&prov=M&dok_var=1&dok_ext=htm.

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21

Babi, Almenar Javier. "Characterisation, biophysical modelling and monetary valuation of urban nature-based solutions as a support tool for urban planning and landscape design." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/288810.

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The recognition of nature in the resolution of societal challenges has been growing in relevance. This recognition has been associated with the development of new concepts from science and policy such as natural capital, ecosystem services, green infrastructure, and more recently Nature-Based Solutions (NBS). NBS intends to address societal challenges in an effective and adaptive form providing economic, social, and environmental benefits. The overall aim of this PhD thesis is to develop an environmental and economic assessment of NBS for highly urbanised territories based on rationales and mo

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22

Babi, Almenar Javier. "Characterisation, biophysical modelling and monetary valuation of urban nature-based solutions as a support tool for urban planning and landscape design." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/288810.

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The recognition of nature in the resolution of societal challenges has been growing in relevance. This recognition has been associated with the development of new concepts from science and policy such as natural capital, ecosystem services, green infrastructure, and more recently Nature-Based Solutions (NBS). NBS intends to address societal challenges in an effective and adaptive form providing economic, social, and environmental benefits. The overall aim of this PhD thesis is to develop an environmental and economic assessment of NBS for highly urbanised territories based on rationales and mo

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23

Hunt, Laurence T. "Modelling human decision under risk and uncertainty." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:244ce799-7397-4698-8dac-c8ca5d0b3e28.

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Humans are unique in their ability to flexibly and rapidly adapt their behaviour and select courses of action that lead to future reward. Several ‘component processes’ must be implemented by the human brain in order to facilitate this behaviour. This thesis examines two such components; (i) the neural substrates supporting action selection during value- guided choice using magnetoencephalography (MEG), and (ii) learning the value of environmental stimuli and other people’s actions using functional magnetic resonance imaging (fMRI). In both situations, it is helpful to formally model the underl

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24

Sulieman, Hussein Mohamed [Verfasser]. "Mapping and modelling of vegetation changes in the Southern Gadarif Region, Sudan, using remote sensing : land-use impacts on biophysical processes / Hussein Mohamed Sulieman." Dresden : TUDpress, 2008. http://d-nb.info/997493739/34.

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25

Sulieman, Hussein Mohamed. "Mapping and Modelling of Vegetation Changes in the Southern Gadarif Region, Sudan, Using Remote Sensing." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1199964393472-79860.

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The study was conducted at the vicinity of the rural town of Doka in an area of about 55 x 40 km2. The aim of the study was to map and model the influences of the introduction of mechanized rain-fed agriculture and its rapid expansion on the natural vegetation in the southern Gadarif Region. To achieve these objectives the study utilized a series of techniques. Beside the intensive use of remote sensing imagery, interviews with key informants and farmers as well as detailed field surveys were carried out. Multi-temporal analyses of remote sensing imagery showed that during the seventies the av

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26

Poignant, Floriane. "Physical, chemical and biological modelling for gold nanoparticle-enhanced radiation therapy : towards a better understanding and optimization of the radiosensitizing effect." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1160.

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En radiothérapie, les nanoparticules faites de métaux lourds telles que les nanoparticules l’or (AuNPs) ont démontré des propriétés radiosensibilisantes particulièrement prometteuses. Une augmentation de la dose et du nombre de radicaux produits, à échelle tumorale (effet photoélectrique) et à échelle sub-cellulaire (électrons Auger) pourraient être responsables d’une partie des effets pour les rayons X de basse énergie. Dans le cadre de cette thèse, nous proposons d'étudier ces mécanismes physiques et chimiques précoces par des outils de simulation, afin de mieux les quantifier et comprendre

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27

Velic, Amar. "Mechanics of bacterial interaction and geometry enhancement on nanopatterned surfaces." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212531/1/Amar_Velic_Thesis.pdf.

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This thesis investigated the deformation and resulting antibacterial activity of bacteria on nanopatterned surfaces, to understand how these surfaces elicit their physical killing action and how they can be optimised. Through finite element and experimental investigation, it was demonstrated that nanopatterned surfaces kill bacteria at their tips by delivering lethal deformation which can be enhanced by reducing key nanopattern dimensions. The findings help towards the development of a new generation antimicrobial materials to combat biofilm infection, fomite transmission and emerging resistan

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28

Fernandes, Gonçalo. "Imaging transcription in living embryos to decipher the robustness of patterning." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS025.

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Au cours du développement, les gradients morphogénétiques fournissent l’information positionnelle nécessaire à l’établissement des axes de polarité. Si l’importance de ces gradients est bien établie, la façon dont ils assurent la reproductibilité des patrons d’expression malgré la nature stochastique de la transcription reste énigmatique.Pour répondre à cette question, j’étudie l’établissement de l’axe antéro-postérieur (AP) de l’embryon de drosophile, sous contrôle de Bicoid (Bcd), un facteur de transcription et morphogène bien connu. Les ARNs de bcd sont exprimés maternellement et ancrés au

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29

Trotter, Daniel. "Ramifications of Vesicle Release Properties on Information Processing at Central Synapses." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41628.

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Synapses communicate temporal sequences of action potentials between neurons with variant efficacy, allowing the same axon to convey independent messages to multiple post-synaptic targets. Several molecular mechanisms control information flow in neural networks. In the hippocampus, transmission responses are highly variable even at the level of individual synapses across different cell types and changes dynamically on the multiple time scales on which it operates. Modeling synaptic transmission and dynamics requires balancing the model’s interpretability and its ability to espouse experimental

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30

Sumner, Christian John. "Spatio-temporal processing in auditory modelling." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300846.

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31

Choi, Cecilia. "A biophysically detailed mathematical model of a single late pregnant rat myometrial cell." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/a-biophysically-detailed-mathematical-model-of-a-single-late-pregnant-rat-myometrial-cell(6d2e1178-370a-4de1-b1fb-9660d1ecf799).html.

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While premature birth is still one of the major clinical problems worldwide, the exact physiological mechanisms underlying myometrium activity during pregnancy remain unclear. In this thesis, a novel biophysically detailed model was constructed using available experimental data to simulate chemical, electrical and mechanical activity in a late pregnant rat uterine myocycte. The developed model has been used to elucidate the ionic mechanism underlying myometrium functionality, providing better insights in the function of the uterus during pregnancy. The model consisted of 15 membrane currents,

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32

Barrass, David Bryan. "Mathematical modelling of pulsatility in neuroendocrine systems." Thesis, Sheffield Hallam University, 1993. http://shura.shu.ac.uk/19321/.

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The work described in this thesis concerns the mathematical description of the characteristic oscillatory electrical behaviour of certain neurosecretory cells found in the hypothalamus of the mammalian brain. This study concentrates on those cells which secrete the hormone oxytocin. A model first described by Hodgkin and Huxley is used as a starting point for the derivation of a description comprising a system of coupled non-linear partial differential equations. The equations have been based wherever possible on experimental data relevant to the system being studied. Where this has not been p

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33

Li, Tong. "Cross-scale biophysics modelling of F-actin cytoskeleton in cell." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/82293/1/Tong_Li_Thesis.pdf.

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This thesis is a comparative study of the modelling of mechanical behaviours of F-actin cytoskeleton which is an important structural component in living cells. A new granular model was developed for F-actin cytoskeleton based on the concept of multiscale modelling. This framework overcomes difficulties encountered in physical modelling of cytoskeleton in conventional continuum mechanics modelling, and the computational challenges in all-atom molecular dynamics simulation. The thermostat algorithm was further modified to better predict the thermodynamic properties of F-actin cytoskeleton in mo

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34

Adcock, Charlotte. "Molecular modelling and electrostatic properties of ion channels." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297941.

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35

Gleeson, P. J. "New tools and specification languages for biophysically detailed neuronal network modelling." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1347263/.

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Increasingly detailed data are being gathered on the molecular, electrical and anatomical properties of neuronal systems both in vitro and in vivo. These range from the kinetic properties and distribution of ion channels, synaptic plasticity mechanisms, electrical activity in neurons, and detailed anatomical connectivity within neuronal microcircuits from connectomics data. Publications describing these experimental results often set them in the context of higher level network behaviour. Biophysically detailed computational modelling provides a framework for consolidating these data, for quant

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36

Major, Guy. "The physiology, morphology and modelling of cortical pyramidal neurones." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306063.

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Wang, Jeffrey Bond. "Modelling Mechanical Interactions Between Cancerous Mammary Acini." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14398530.

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The rules and mechanical forces governing cell motility and interactions with the extracellular matrix of a tissue are often critical for understanding the mechanisms by which breast cancer is able to spread through the breast tissue and eventually metastasize. Ex vivo experimentation has demonstrated the the formation of long collagen fibers through collagen gels between the cancerous mammary acini responsible for milk production, providing a fiber scaffolding along which cancer cells can disorganize. We present a minimal mechanical model that serves as a potential explanation for the formati

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38

Ghazzawi, Zaid. "Modelling of the craniofacial skeleton : an investigation of skull biomechanics." Thesis, University of Surrey, 2002. http://epubs.surrey.ac.uk/815/.

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Stockley, Edward William. "Three-dimensional reconstruction and electronic modelling of CA1 hippocampal neurones." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295927.

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40

Tang, Ming. "Atomic-scale biophysics modelling of type I collagen in the extracellular matrix." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/124650/1/Ming_Tang_Thesis.pdf.

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This thesis explores the biophysics of collagen in the extracellular matrix under external stimuli, by performing cutting edge MD simulations. The obtained results provide significant insights into the design and manufacturing of artificial biomaterials for surgical tissue treatments, of collagen for regenerative medicine applications, and of gold nanoparticles for biomedical applications. The probed biophysical properties consist of the structural properties and the mechanical properties, where the mechanical properties of collagen are regulated by its structure at different levels of hierarc

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Nordling, Torbjörn E. M. "Issues on modelling of large-scale cellular regulatory networks." Thesis, KTH, Numerical Analysis and Computer Science, NADA, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4182.

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<p>Vi har identifierat flexibelt utbyte och lagring av data i databaser, tillsammans med långvarig satsning på olika existerande och framtida modeller som nyckar till förståelse av det regler nätverk som utgör bron mellan geno- och fenotyp. Denna pilot studie av modellering av stora cellulära kontroll nätverk utgår från en intressant medicinsk frågeställning inom molekylär cellbiologi: Är framtvingad expression av Cdc6, aktivering av Cdk4/6 och Cdk2 tillräcklig för förankringsfri entré av cell cykelns S fas? Vi försöker konstruera en modell för att besvara denna fråga, på så sätt att vi kan de

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Qi, Li. "Non-linear finite-element modelling of newborn ear canal and middle ear." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21904.

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Early hearing screening and diagnosis in newborns are important in order to avoid problems with language acquisition and psychosocial development. Current newborn hearing screening tests cannot effectively distinguish conductive hearing loss from sensorineural hearing loss, which requires different medical approaches. Tympanometry is a fast and accurate hearing test routinely used for the examination of conductive hearing loss for older children and adults; however, the tympanograms are hard to interpret for newborns and infants younger than seven months old due to significant differences in t

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43

Li, Chen. "Biophysically detailed modelling of the pro-arrhythmic effects of heart failure-induced ionic remodelling." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/biophysically-detailed-modelling-of-the-proarrhythmic-effects-of-heart-failureinduced-ionic-remodelling(b761b2b9-5bea-4d38-82b0-aa3c74eab967).html.

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Heart Failure is a common long term progressive and serious medical condition with high mortality and costly health services in the UK. By the year of 2010, there were around 90,000 people in the UK suffered from heart failure and in 2008, 10,000 heart failure patients were recorded death. Treatments of heart failure cost the National Health Service around £625 million every year. Although heart failure is highly pro-arrhythmic, the underlying mechanisms of the pro-arrhythmic effects of heart failure are not completely understood. Heart failure is associated with electrical remodelling of the

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44

Ouldridge, Thomas E. "Coarse-grained modelling of DNA and DNA self-assembly." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b2415bb2-7975-4f59-b5e2-8c022b4a3719.

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In this thesis I present a novel coarse-grained model of deoxyribonucleic acid (DNA). The model represents single-stranded DNA as a chain of rigid nucleotides, and includes potentials to represent chain connectivity, excluded volume, hydrogen-bonding and base stacking interactions. The parameterization of these interactions is justified by comparing the model's representation of a range of physical phenomena to experimental data. In particular, the geometrical structure and elastic moduli of duplex DNA, and the flexibility of single-stranded DNA, are shown to be physically reasonable. Addition

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Maksym, Geoffrey N. "Modelling lung tissue theology." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42087.

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A model was developed to account for the static elastic behaviour of the lung tissue strip in terms of distributions of collagen and elastin fibers. Distributions of collagen fiber lengths and elastin fiber stiffnesses were determined by fitting the model to data from dog lung tissue strips. These distributions followed 1/f power-laws for more than 95% of the data. Computer simulations of two dimensional tissue strip models with 1/f distributions of collagen fiber lengths also predicted realistic stress-strain curves. The simulations illustrated the gradual development of geometric and stress

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Khanal, Bishesh. "Modélisation et simulation réaliste d'IRMs cérébrales structurelles longitudinales avec atrophie appliquées à la maladie d'Alzheimer." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4046/document.

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Dans cette thèse, nous avons développé des outils pour simuler des imageslongitudinales réalistes de cerveau présentant de l’atrophie ou de lacroissance. Cette méthode a été spécifiquement élaborée pour simuler leseffets de la maladie d’Alzheimer sur le cerveau. Elle se fonde sur un modèle dedéformation du cerveau qui décrit les effets biomécaniques d’une perte detissue due à une carte d’atrophie prescrite. Nous avons élaboré une méthodepour interpoler et extrapoler les images longitudinales d’un patient en simulantdes images avec une carte d’atrophie spécifique au sujet. Cette méthode a étéut

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Sulc, Petr. "Coarse-grained modelling of nucleic acids." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3e1573ec-033c-4971-85e1-ccecd57e7f70.

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This thesis considers coarse-grained models of DNA and RNA, developed in particular to study nanotechnological applications as well as some important biophysical processes. We first introduce sequence-dependent thermodynamics into a previously developed coarse-grained rigid base-pair model of DNA. This model is then used to study sequence-dependent effects in multiple DNA systems including: the heterogeneous stacking transition of single strands, the fraying of a duplex, the effects of stacking strength in the loop on the melting temperature of hairpins, the force-extension curve of single str

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Ainsley, Jon. "Computational simulations of enzyme dynamics and the modelling of their reaction mechanisms." Thesis, Northumbria University, 2017. http://nrl.northumbria.ac.uk/36286/.

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Proteins and enzymes are large and complex biological molecules, characterized by unique three-dimensional structure are highly flexible and dynamic nature. Thorough understanding of protein and enzyme function requires studying of their conformational flexibility, because important physiological processes, such as ligand binding and catalysis rely on an enzyme’s dynamic nature and their ability to adopt a variety of conformational states. Computational methods are widely applied in studying enzymes and proteins structure and function providing a detailed atomistic-level of resolution data abo

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Adeniran, Ismail. "Biophysically detailed modelling of the functional impact of gene mutations associated with the 'short QT syndrome'." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/biophysically-detailed-modelling-of-the-functional-impact-of-gene-mutations-associated-with-the-short-qt-syndrome(f602c1f4-4290-469e-a66a-878198b17c7d).html.

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The recently identified genetic short QT syndrome is characterised by abbreviated QT intervals on the electrocardiogram, an increased risk of atrial and ventricular arrhythmias, and an increased risk of sudden death. Although the short QT syndrome has been suggested to provide a paradigm for increasing understanding of the role of potassium channels in ventricular fibrillation, the basis for arrhythmogenesis in the short QT syndrome is incompletely understood. There are no animal models that accurately reproduce a short QT phenotype, and whilst in vitro electrophysiology of short QT mutant cha

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Thompson, Neill Stuart. "Musculoskeletal modelling in the assessment of lower limb biomechanical pathology in cerebral palsy children and the effects of interventions to improve their gait." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301748.

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