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Dissertations / Theses on the topic 'Biophysics cells'

Author: Grafiati
Published: 28 May 2022
Last updated: 31 July 2025

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1

Hukin, David James John. "Water relations and biophysics of plant cells." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398699.

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2

Testorf, Martin. "Melanophores : cell biophysics and sensor applications /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/tek687s.pdf.

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3

Hewitt, Michael J. "Computer models of auditory inner hair cells and cochlear nucleus stellate cells." Thesis, Loughborough University, 1992. https://dspace.lboro.ac.uk/2134/27900.

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This thesis presents five, separate but interlinked, studies of computer models of cells in the mammalian auditory system. The first study presents a comparative evaluation of eight computer models of inner hair cell function. The models simulate the release of a chemical transmitter substance from the base of a hair cell in response to sound stimulation. The simulations take the form of differential equations which are evaluated 20,000 times per second of simulated events. The models were evaluated in terms of their agreement with physiological data and their computational efficiency.
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4

Liu, Julia Chang. "DNA-damage-induced apoptosis in stem and cancer cells." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11325.

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This work comprises analyses of cell fate decision-making in response to DNA damage. DNA damage is a ubiquitous threat to genomic stability, and depending on the type and extent of the damage, can lead to widespread changes in cell function as well as cell death. How apoptosis, or programmed cell death, is triggered in damaged cells was studied in different cell types for different types of damage.
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5

Niese, Brandon A. "Fabrication of microfluidic devices to probe cell mechanical properties of MDA-MB-231 human breast cancer cells." Ohio University Honors Tutorial College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556626033175996.

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6

Alexopoulos, Evangelos Demetrios. "Extracellular matrix associated with human luteinizing granulosa cells." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369867.

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7

Tha, Susan P. L. "Interaction forces between human red cells aggutinated by antibody." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75421.

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A theoretical and experimental method is described whereby the hydrodynamic forces, both normal and shear, acting on the spheres of a doublet can be calculated. This is applied to a system of sphered human red blood cells agglutinated by human hyperimmune anti-B antiserum undergoing Poiseuille flow and observed using the traveling microtube technique. The mean forces separating the cells of individual doublets were found to be proportional to antiserum concentration from 0.73 to 3.56% v/v, normal forces increasing from 0.060 to 0.197 nN and shear forces from 0.023 to 0.072 nN. It was impossibl
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8

Xing, Shu. "Intercellular communication between bone cells induced by mechanical stimulation." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114355.

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Mechanical loading is crucial in modulating the physiology and architecture of bone. Previous experiments indicated intercellular communication among osteoblasts upon mechanical stimulation, suggesting the involvement of a soluble signal mediator. Extracellular adenosine triphosphate (ATP) functions as signaling molecules in many cell regulation processes, therefore appears to be a prone candidate. ATP acts on osteoblasts through multiple P2 receptors. To provide insights on the roles of individual receptors, we modeled ATP concentration dependence for different P2 receptors. Next, the pro
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9

Keen, Leigh John. "The growth and pharmacology of insect glial cells in vitro." Thesis, Oxford Brookes University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359837.

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10

Jalalahmadi, Golnaz. "Development of A New Methodology for Contact Angle Measurment on Monolayer of Cells." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1374765701.

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11

Ferguson, Joshua Paul. "Clathrin-Mediated Endocytosis as a Marker of Cell Membrane Tension in Cultured Cells and Developing Organisms." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534434899256265.

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12

Boltyanskiy, Rostislav. "Mechanical Response of Single Cells to Stretch." Thesis, Yale University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10160860.

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<p> A living cell is a complex soft matter system far from equilibrium. While its components have definite mechanical properties such as stiffness and viscosity, cells consume energy to generate force and exhibit adaptation by modulating their mechanical properties through regulatory pathways. In this dissertation, we explore cell mechanics by stretching single fibroblast cells and simultaneously measuring their traction stresses. Upon stretch, there is a sudden, drastic increase in traction stresses, often followed by a relaxation over a time scale of about 1 minute. Upon release of stretch,
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13

Chambers, Kelley Ann. "Immune damage in irradiated mice: Contributions of differential radiosensitivity and apoptosis in mononuclear cells, and alterations in natural killer cell cytolytic potential." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/10180.

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Damage to the immune system of exposed individuals renders the host susceptible to opportunistic infection and disease. The purpose of this investigation was to contribute to the understanding of mechanisms underlying depression of host immune responses following radiation exposure. Peripheral blood mononuclear cells (PBMC) of mice irradiated with 0-700 rad $\gamma$-whole body irradiation (WBI) were analyzed by flow cytometry (FCA). Natural killer (NK) cells and CD4+ T lymphocytes were selectively enhanced following radiation exposure, demonstrating radioresistance of these cell types over oth
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14

Hébert, Benedict. "Spatio-temporal image correlation spectroscopy : development and implementation in living cells." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102507.

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The object of this thesis is to develop a new extension of Image Correlation Spectroscopy (ICS) that can measure velocity vectors for flowing protein populations in living cells. This new technique, called Spatio-Temporal Image Correlation Spectroscopy (STICS), allows measurement of both diffusion coefficients and velocity vectors (magnitude and direction) from fluorescence microscopy image time series of fluorescently labeled cellular proteins via monitoring of the time evolution of the full space-time correlation function of the intensity fluctuations. By using filtering in Fourier space to
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15

Li, Sihong, and 李思宏. "Quantitative observation and modulation of cellular dynamics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206358.

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Stem cell research provides a useful tool for unraveling the molecular mechanisms and shedding light on cell transplantation therapies. Traditional qualitative experimental observation lacks the rich dynamic information, and therefore prevents obtaining the insight into cellular processes such as stochastic cell fate control and biological pattern formation. Quantitative approach helps promote research of these challenges. As passive measurements, the available commercial solutions have their own drawbacks and need to be improved to fulfill specialized requirements of the cutting edge studies.
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16

Jagger, Daniel James. "Modulation of ion channels in outer hair cells from the mammalian cochlea." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336876.

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17

Khayat, Ghazaleh. "Low frequency stimulation of stem cells in dynamic culture modulates differentiation pathways." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119594.

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Living cells, depending on their physiological functions, are subjected to a variety of mechanical stimulation. The magnitude and frequency of such mechanical stimulation varies dramatically in different organs. Oscillatory mechanical stimulation at relatively high frequancies, as occurs in walking, respiration and circulation, is one of the most extensively studied schemes. However, the stimulation at extremely low frequencies is rarely examined. This research investigates the effects of relatively low frequency mechanical stimulation in molecular scale, on different cell types. Throughout t
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18

Olofsson, Per. "Microwell-based Collagen Matrix Migration Assays for NK:target Cell Interactions : Three-dimensional Imaging and Analysis of Transient Migration Behavior of NK Cells in vitro." Thesis, KTH, Cellens fysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-43456.

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Natural killer (NK) cells are lymphocytes of the innate immune system responsible for lysing tumor and virally-infected cells. Investigating NK cell heterogeneity can inform the development of more efficacious immunotherapeutic treatments. Cell motility is an essential aspect of NK cell function. Moreover, the cell migration behavior within cell populations displays a marked heterogeneity. For some time it has been clear that cell-matrix interactions can radically alter the behavior of certain types of cells. (1) However, conventional studies of cell migration have relied on flat (2-D) surface
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19

Nauseef, Jones Trevor. "An investigation of the molecular and biophysical properties of metastatic cells." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/3150.

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Prostate cancer presents a significant paradox: it is very common, yet rarely fatal. To wit, the prostate is the most common non-skin tissue for cancer diagnosis in men in the United States. Despite its high incidence, fatal malignancy occurs in only a small fraction of diagnosed men. The fatal cases are characteristically defined by distant spread in the body, also known as metastasis. In order to metastasize a cancer cell must complete several sequential steps. These include degradation of and invasion through the epithelial basement membrane, typically through the loss of static intracellul
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20

Simon, Andrew H. "Watching Sugar Transport in Real Time in Single Cells and Cell Populations." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/963.

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The facilitative glucose transporter GLUT1 catalyzes the passive translocation of glucose across plasma membranes. Previous studies have demonstrated that regulation of GLUT1 activity is complex and subject to modulation by a variety of environmental and allosteric effectors. Mathematical models of GLUT1 kinetics have been derived which successfully account for subsets of these factors, though efforts to develop a single kinetic theory has not yet been achieved. Limitations in conventional experimental methodologies cannot provide kinetic data with the precision and continuity needed for furth
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21

Billock, Vincent Alan. "Hue and luminance multiplexing in type I r-g cells /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487330761219187.

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22

Stevens, Edward Benedict. "An electrophysiological study of voltage gated membrane currents in rat and mouse thymic nurse cells." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299239.

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23

Lin, Ya. "Single-molecule techniques to probe the dynamic gene regulatory network formed by core pluripotency circuit in embryonic stem cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070085.

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This work investigates the dynamics of gene regulatory network formed by Oct4, Sox2 and Nanog in embryonic stem cells (ESCs). Despite a large number of existing studies on stem cells, current technologies used often force a compromise between quantification of gene expression via bulk measurements and qualitative imaging of cell heterogeneity. There are few options that allow for accurate and quantitative single-cell analysis that is robust yet not associated with a high degree of technical difficulty or obscured by amplification. Here, we adapted a high resolution, single-molecule RNA fluores
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24

Rios, Villanueva Xavier. "Toward Multiplex Genome Engineering in Mammalian Cells." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11179.

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Given the explosion in human genetic data, new high-throughput genetic methods are necessary for studying variants and elucidating their role in human disease. In Chapter I, I will expand on this concept and describe current methods for genetically modifying human cells. In E. coli, Multiplex Automatable Genome Engineering (MAGE) is a powerful tool that enables the targeting of multiple genomic loci simultaneously with synthetic oligos that are recombined at high frequencies in an optimized strain. MAGE as a method has two components: organism-specific optimization of oligo recombination para
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25

Ho, Shuang-Bao. "Corticotropin-releasing factor-41 (CRF-41), arginine vasopressin (AVP) and oxytocin regulation in hypothalamic cells in culture." Thesis, Brunel University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306850.

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26

ETHIRAJ, SINDUJA. "Cell-Cell Junction Signaling Regulating DNA Double-Strand Break Repair In Breast Cells." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/132.

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Genomic instability and acquisition of invasiveness through the basement membrane extracellular matrix (ECM) are two major processes for epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced breaks such as those induced during radiation therapy to treat breast cancer patients are repaired by DSBR, rendering this pathway relevant for therapy as well. DSBR can occur either by homologous recombination (HR) or non-homologous end-joining (NHEJ). HR is accepted
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27

Georgiou, George N. "Application of fluorescence digital imaging microscopy to the study of interactions of influenza virus and photodynamic photosensitizers with cells." Thesis, University of Essex, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282630.

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28

Chhun, Bryant B. "Super-resolution video microscopy of live cells by structured illumination." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1473623.

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29

Ishihara, Keisuke. "On the growth of microtubule asters spanning millimeter-sized cells." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718712.

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The large cells in early vertebrate embryos are organized by radial arrays of microtubules called asters. Asters grow, interact, and move to precisely position the cleavage planes of for each cell division. Cell-spanning dimensions are presumably required for interphase asters to explore the size and shape of the large cytoplasm. It has been unclear whether asters grow to fill the enormous egg according to the standard model of aster growth proposed in smaller somatic cells, or whether special mechanisms are required. In this dissertation, I combine biochemical reconstitution and biophysical m
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30

Josef, Keith. "The nonlinear phototaxis signaling network of Chlamydomonas investigated by observing ciliary responses of individual cells to green and red light." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2005. http://wwwlib.umi.com/cr/syr/main.

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31

Walker, Angela. "Electrochemical study of vesicular release in bovine chromaffin cells." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23431.

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The time course of the spontaneous current spikes produced by the release of the catecholamines from individual vesicles was examined in bovine chromaffin cells by using the carbon filament technique in the amperometric mode.<br>Frequency histograms of the rise and decay times of the current spikes showed a paucity of very short duration events. Scatterograms of the rise and decay times consistently showed a positive relation, and the best fitted lines intercepted the ordinate (the axis of the decay time) at: 16.06 $ pm$ 6.45 msec (n = 11).<br>The effect of temperature changes upon the time co
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32

Krieger, Brenna M. "Predicting the Electrophysiological Responses of Murine Alpha Retinal Ganglion Cells to Artificial and Natural Visual Stimuli." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226061.

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The retina sends many parallel channels of visual information to the brain through the axons of >20 retinal ganglion cell (RGC) populations. The purpose of these distinct circuits for vision remains an open question. Recent results suggest that each cell type responds selectively to a specific feature of the visual scene. These conclusions are derived primarily from experiments with artificial visual stimuli. It is unknown whether the insights gathered under such conditions extend to the natural environment in which the retina evolved. One can address this question by building a mathematical m
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33

Tuglu, Mehmet Ibrahim. "Analysis of the behaviour of retinal pigment epithelial (RPE) cells in relation to their maintenance in the epithelium during development of the chick eye." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.480920.

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34

Khamesian, Mahvand. "Mechanisms of High Sensitivity and Active Amplification in Sensory Hair Cells." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153243238506078.

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35

Yuan, Fang. "DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/466.

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Lysophosphatidic acid (LPA), a naturally-occurring, simple phospholipid, is present at elevated levels in the blood and ascites of ovarian cancer patients. LPA is a ligand of seven cell surface G protein-coupled receptors. It has been known as an oncogenic growth factor in ovarian cancer and other types of human malignancies. However, the precise biological functions of LPA in ovarian oncogenesis remain to be fully elucidated. Our laboratory is interested in studying the potential role of LPA, as a tumor microenvironment factor, in regulation of cancer cell metabolism. A fundamental change ass
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36

Garg, Ayush A. "Electromagnetic Fields Alter the Motility of Metastatic Breast Cancer Cells." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563816767104018.

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37

Генега, А. Б., та Д. І. Санагурський. "Динаміка трансмембранного потенціалу зародків за дії амінокислотних похідних 1,4-нафтохінону". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32153.

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Динаміка електрофізіологічних показників клітин в період раннього розвитку відображає зміни функціонального стану, зокрема ступінь життєздатності, і може бути прогностичним біофізичним показником їх подальшого виживання. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32153
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38

Trikha, Saurabh. "Unraveling the Molecular Mechanisms of Human Amylin Binding, Turnover and Toxicity in Pancreatic Cells." Thesis, The George Washington University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3590360.

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<p> Islet amyloid polypeptide or amylin is a recently discovered 37 amino acid residue signaling protein (hormone) that is produced and co-secreted along with insulin by pancreatic beta-cells. In late onset of diabetes, amylin readily aggregates forming protein deposits or plaques that are toxic to beta-cells, resulting in beta-cell apoptosis. Given the well-known role of cholesterol and lipids in etiology of diabetes, I explored whether these two essential PM components regulate amylin assembly and aggregation on artificial (synthetic) membranes. Using high resolution imaging and spectroscopi
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39

Dang, David. "LYSOPHOSPHATIDIC ACID IS A MEDIATOR OF INTERLEUKIN-6 PRODUCTION IN OVARIAN CANCER CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1907.

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Lysophosphatidic acid (LPA) is a naturally occurring bioactive lysophospholipid that mediates a broad range of cellular processes such as cell proliferation, survival, migration and invasion. LPA also plays a potential role in human oncogenesis as suggested by elevated expression of its receptors and its producing enzymes in malignant tissues. In the current study, we demonstrated that LPA is a potent mediator of interleukin-6 (IL-6) production in ovarian cancer. IL-6 is a pleiotropic cytokine which is thought to be an important mediator of ovarian cancer development and progression. Here, we
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40

Finski, Alexei. "Multiplex Analytical Measurements in Single Cells of Solid Tissues." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10652.

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Most human organs consist of solid tissues. Most human disorders occur in solid tissues. No two cells are equivalent in native solid tissues as single cells widely vary in their biochemistry, specialization, and location. Yet, the fundamental limitations of solid-tissue processing and analysis have made it challenging to access the richness of molecular information in single cells of animal and human solid tissues. We have eliminated a set of limitations of solid-tissue processing and analysis. In this thesis, I first describe a new method for sampling single cells in live solid tissues. This
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Zhu, Yueming. "Polychlorinated biphenyl (PCB)-induced oxidative stress mediates cytotoxicity in human breast and prostate epithelial cells." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/3026.

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This thesis describes studies that are designed to investigates the hypothesis that mitochondrial production of reactive oxygen species (O2*- and H2O2) cause oxidative stress during PCB exposure and this increased production of ROS contributes to the biological effects of PCBs on cell proliferation in human breast and prostate epithelial cells. Exponentially growing non-malignant human breast epithelial cells (MCF-10A) and non-malignant human prostate epithelial cells (RWPE-1) were treated with selected PCBs an
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42

LeBlanc, Julie-Maude. "Interaction between cisplatin and radiation in the treatment of ovarian cancer cells." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26337.

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The A2780s is a cisplatin and radiation-sensitive human ovarian carcinoma cell line from which the more resistant variant, A2780cp, was derived. In vitro experiments on the radiosensitivity of these cells with different treatments may be representative of the in vivo radiosensitivity, and maybe of use to patients receiving radiotherapy. Therefore, many studies have been directed at evaluation of the inhibition of DNA repair in order to improve radiotherapy. Previous studies showed that drugs and hyperthermia are repair inhibitors increasing the effectiveness of radiation. Cisplatin can also r
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Bianchi, Giulio. "Mechanical properties of cytoskeleton proteins studied in living cells by combining optical tweezers and deformability cytometry." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1143608.

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The topic of this thesis focuses on studying the mechanical properties of the living cell plasma membrane and the mechanical associations of the plasma membrane with the underlying cytoskeleton. The mechanical properties of the cell components, cell plasma membrane and cytoskeleton, as well as membrane-cytoskeleton associations, determine the mechanical properties of the whole cell, important for cellular shape changing behavior and mechanical signal transduction in living cells. Examples of biological processes involving cellular shape changes are deformation of erythrocytes in capillaries, c
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Verstreken, Christophe. "Studying the direct effects of forces on embryonic stem cell behaviour." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283499.

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Cells experience different mechanical cues from their local environment, including shear flow, forces applied by neighbouring cells, and substrate stiffness. These external signals influence cell behaviour, also in embryonic stem (ES) cells, where they could potentially affect pluripotency or differentiation. The precise effects of external forces on ES cells are confounded by forces inducing secondary changes to attachment or cell-cell signalling, which themselves can also influence cell behaviour. In this study we developed a set-up to attach cells to elastic membranes using a novel function
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Lembersky, Dmitry. "THE SECOND GENERATION PROTEASOME INHIBITOR CARFILZOMIB INTERACTS SYNERGISTICALLY WITH HDAC INHIBITORS IN DIFFUSE LARGE B-CELL LYMPHOMA CELLS THROUGH MULTIPLE MECHANISMS AND CIRCUMVENTS BORTEZOMIB RESISTANCE." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1800.

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Mechanisms underlying the interactions between the proteasome inhibitor carfilzomib and HDAC inhibitors were examined in both germinal center (GC) and activated B-cell (ABC) subtypes of human diffuse large B-cell lymphoma (DLBCL). Simultaneous exposure to minimally toxic concentrations of carfilzomib and HDAC inhibitor vorinostat resulted in the release of mitochondrial pro-apoptotic proteins SMAC and cytochrome c, pro-apoptotic caspase activation, and synergistic induction in apoptosis in both ABC and GC DLBCL subtypes. These events were associated with a marked increase in the stress kinas
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Larsen, James D. "Nicotinic Acetylcholine Receptor Dependent Effects of Nicotine on HEK293T and HBO Cells." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5701.

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T2R receptors are the classical bitter taste receptors which detect and transduce bitter taste in a subset of taste receptor cells (TRCs). The TRPM5-dependent T2Rs are G-protein coupled receptors (GPCRs) and are linked to G protein, gustducin to initiate an intracellular signaling cascade for the transduction of bitter tastants. Nicotine is bitter. However, at present the transduction mechanisms for the detection of nicotine in are poorly understood. Previous studies from our laboratory using TRPM5 knockout (KO) mice demonstrated that the T2R pathway is insufficient in explaining the taste per
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Karikari, Kwasi. "Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/790.

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Apoptosis is a form of programmed cell death that is essential in such processes as organ and tissue remodeling and maturation of hematopoietic cells. The clearance of apoptotic cells is essential to prevent autoimmune responses to sequestered antigens. This process is mediated by phagocytes of the monocyte lineage. Before phagocytosis can occur, macrophages must be recruited to the apoptotic cells through chemotaxis. Products of the reaction catalyzed by the phospholipases A2 (PLA2) have been shown to induce monocyte chemotaxis either directly or indirectly. Some investigators have implicated
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Mohammadalipour, Ameneh. "Mechanical Properties of Cancer Cells: A Possible Biomarker for Stemness." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1420642948.

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49

Landgraf, Dirk. "Quantifying Localizations and Dynamics in Single Bacterial Cells." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10612.

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Levels of macromolecules fluctuate both spatially and temporally in individual cells. Such heterogeneity could be exploited for bet hedging in uncertain environments, or be suppressed by negative feedback if perturbations are deleterious. For the master stress-response regulator in Escherichia coli, RpoS, both of these scenarios have been suggested. RpoS levels are also exceedingly low and controlled by the ClpXP protease, which reportedly displays extreme spatial heterogeneity. However, little is known quantitatively about RpoS dynamics. This is partly because no functional protein fusions ex
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Dazzoni, Régine. "Unravelling the role of Nuclear Membrane dynamics in the behaviour of cancer cells : A multidisciplinary approach using cell biology, advanced imaging and biophysics." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0310.

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Abstract:
Des malformations de l’enveloppe nucléaire sont observées dans des maladies de dystrophie musculaire ainsi que dans certains types de cancer tels que le cancer du sein ou du rein. Les mécanismes impliqués dans le maintien de la morphologie de l’enveloppe nucléaire sont basés sur des interactions protéo-lipidiques. Il a été démontré récemment que les propriétés physiques de lipides spécifiques jouent un rôle dans le processus de formation de l’enveloppe nucléaire chez le modèle de l’oursin. Afin de comprendre l’implication des lipides dans la régulation de l’architecture de l’enveloppe nucléair
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