Relevant bibliographies by topics / Biophysics, Medical

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Biophysics, Medical'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Biophysics, Medical"

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Feitelberg, Sergei. "BIOPHYSICS AND MEDICAL ENGINEERING." Annals of the New York Academy of Sciences 128, no. 2 (December 16, 2006): 561–67. http://dx.doi.org/10.1111/j.1749-6632.1965.tb11667.x.

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Samoylov, A. S., A. Yu Bushmanov, and S. F. Goncharov. "State Scientific Center of the Russian Federation — Federal Medical Biophysical Center Named after A.I. Burnazyan of FMBA of Russia: 75 Years on Guard of People's Health." Disaster Medicine, no. 3 (September 2021): 5–9. http://dx.doi.org/10.33266/2070-1004-2021-3-5-9.

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The article presents the history of creation, formation and development of the State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia (A.I. Burnazyan Federal Biophysical Center, the Center). The Institute of Biophysics of USSR Ministry of Health and Clinical Hospital № 6, predecessors of the Center, were engaged in the elimination of medical and sanitary consequences of Chernobyl Radiation Accident (1986). The main directions of activities of the A.I. Burnazian Federal Medical Biophysical Center — the flagship institution of Russian health care in the field of biophysics, radiation and nuclear medicine are considered. The perspectives of scientific activity of the Center related to solving actual problems of modern radiobiology, radiation safety and biomedical technologies are outlined. It is concluded that it is expedient to create the Disaster Medicine Service of the Federal Medical and Biomedical Agency of Russia.
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Gango, Sergei, Svetlana Pan'kova, Vladimir Solovyev, Alexander Vanin, and Mikhail Yanikov. "TEACHING METHODS IN THE UNIVERSITY COURSE “BIOPHYSICS”." SOCIETY. INTEGRATION. EDUCATION. Proceedings of the International Scientific Conference 1 (May 25, 2018): 103. http://dx.doi.org/10.17770/sie2018vol1.3206.

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The article presents some methods and results of experimental teaching biophysics at Pskov State University (Russian Federation). The goal of any university is to train highly qualified specialists. To achieve this aim, the authors suggest following interdisciplinary approach to the educational process. Some topics of the lecture presentations, video clips and demonstration educational experiments as well as examples of computer modelling of biophysical processes are considered. Subjects of the real and virtual biophysical, biological and medical experimental tasks for students working in an educational university physical laboratory are discussed.
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Ito, Etsuro. "Preface of Special Issue “TRP channels: their functional roles in medical sciences”." BIOPHYSICS 11 (2015): 7–8. http://dx.doi.org/10.2142/biophysics.11.7.

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Glaser, R. "An Introduction of Biophysics with Medical Orientation." Journal of Electroanalytical Chemistry 343, no. 3 (October 1992): 499. http://dx.doi.org/10.1016/0022-0728(92)85117-l.

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Glaser, R. "An Introduction of Biophysics with Medical Orientation." Bioelectrochemistry and Bioenergetics 28, no. 3 (October 1992): 499. http://dx.doi.org/10.1016/0302-4598(92)80043-g.

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Reeves, Glen I. "Biophysics and Medical Effects of Enhanced Radiation Weapons." Health Physics 103, no. 2 (August 2012): 150–58. http://dx.doi.org/10.1097/hp.0b013e31824abef5.

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Panchenko, Anna. "Decoding Molecular Mechanisms of Disease with Medical Biophysics." Biophysical Journal 118, no. 3 (February 2020): 491a. http://dx.doi.org/10.1016/j.bpj.2019.11.3378.

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Chernysh, A. M., D. S. Belopakhov, A. A. Belyaevskaya, A. V. Zakaryan, M. S. Kupriyanova, M. A. Postnikov, E. V. Sergeenko, and I. M. Shogenov. "Scientific Practicum for Students of the Specialty «Medical Biophysics»." General Reanimatology 12, no. 4 (January 1, 2016): 79–88. http://dx.doi.org/10.15360/1813-9779-2016-4-79-88.

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Ignatov, Ignat, and Oleg Mosin. "Scientific Research Center of Medical Biophysics (SRC MB), Bulgaria." Nanotechnology Research and Practice 6, no. 2 (June 15, 2015): 72–80. http://dx.doi.org/10.13187/ejnr.2015.6.72.

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Dissertations / Theses on the topic "Biophysics, Medical"

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Studholme, Colin. "Measures of 3D medical image alignment." Thesis, King's College London (University of London), 1997. https://kclpure.kcl.ac.uk/portal/en/theses/measures-of-3d-medical-image-alignment(7e3dd0a9-6dc2-4ff0-8b9f-8fd513728ffb).html.

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McAuley, Bernard. "Principles of a-Si:H photodiodes for medical X-ray imaging." Thesis, University of Surrey, 1998. http://epubs.surrey.ac.uk/843988/.

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In this thesis we assess the use of a-Si photodiodes for medical X-ray imaging. The design of an a-Si X-ray imager based on an active matrix, suitable for medical imaging is outlined. The key points in the design are highlighted, and the role of the a-Si photodiode is discussed. We outline the underlying physics of photodiodes, with particular attention to a-Si, and review the current literature. Based on this a model suitable for simulation has been developed. This model is able to replicate the thickness independence of a-Si diodes without resorting to an arbitrary charge at the p/i interface. Because individual pixels must be isolated, a certain fraction of any pixel will have to be contactless. This causes a considerable loss of signal. The possibility of retrieving this lost signal by using a lateral field was examined using the above model. Five structures were examined. (1) A basic photodiode with a longer top contact than the bottom contact. (2) A junction focussed photodiode where an addition junction contact is placed between the contacts on the bottom to induce a lateral field. (3) An insulated focussed photodiode where an insulated contact is placed between the contacts on the bottom of the diode to induce a lateral field. (4) A skewed photodiode, where the top and bottom contacts are deliberately misaligned to generate a lateral potential. (5) A skewed photodiode with additional insulating contacts on the top and bottom to improve the lateral potential. The focussing elements in these devices were show to have varying degrees of efficiency. It was noted that the current models for recombination would not be suitable for transient simulations. Also, as they neglect the presence of amphoteric defects it seems likely that they would underestimate the recombination. An examination of the current dangling bond models was undertaken with a view to using these in simulations. However, application of these models to the problem at hand revealed limitations in their use. A new approach was tried, using a transient analysis, but this was also found to be wanting. Finally, possible paths for future work are discussed, along with the apparatus constructed for measurements to corroborate the simulation results.
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Levesque, Ives. "Quantitative magnetic resonance imaging of magnetization transfer and T2 relaxation in human white matter pathology." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66751.

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The primary aim of this thesis is the reconciliation of two seemingly disparate quantitative magnetic resonance imaging (MRI) techniques proposed to characterize human brain white matter (WM) in health and disease. Quantitative magnetization transfer imaging (QMTI) and multi-component analysis of T2 relaxation (QT2) both attempt to quantify myelin content in vivo, but are based on fundamentally different models of WM. QMTI probes the macromolecular component of tissue using a two-pool model of magnetization transfer, while QT2 isolates the water signal from distinct micro-anatomical compartments. The specific objectives were to determine the interrelationship between measurements made with both techniques in the context of potential pathological changes associated with multiple sclerosis (MS), and to apply both to track WM changes in the acute phase of MS lesions. First, simulations were used to evaluate the theoretical sensitivity of each technique to the characteristics of a model of WM that incorporates four pools of magnetization, based on published in vitro measurements. Next, the experimental reproducibility of each technique was investigated, and the impact of certain basic variations in the data acquisition and analysis procedures was evaluated. In the final stage, both methods were applied longitudinally in vivo to assess the dynamic changes that occur in acute, contrast-enhancing lesions of MS. The theoretical results illustrate the sensitivity and limitations of QMTI and QT2 to specific pathology-inspired modifications of WM, and shed new light on the potential specificity of often-neglected QMTI parameters. The reproducibility of both techniques is acceptable for use in repeated clinical measurements, and QMTI has lower variability overall. The importance of corrections for magnetic field inhomogeneity in QMTI is demonstrated, and a simple optimization of the QMTI data acquisition is introduc
L'objectif principal de cette thèse est la réconciliation de deux techniques quantitatives d'imagerie par résonance magnétique, en apparence difféerentes, utilisées pour la caractérisation de la susbtance blanche du cerveau humain en santé ou affectée par la maladie. Les techniques d'imagerie quantitative par transfert de magnétisation (QTM) et d'analyse de la relaxation T2 par de multiples composantes (QT2) proposent toutes deux des mesures in vivo de la quantitée de myéline, mais à l'aide de modèles fondamentalement différents. D'un côté, l'imagerie QTM sonde la composante macro-moléculaire des tissues à l'aide d'un modèle à deux réservoirs pour le transfert de magnétisation. De l'autre, l'imagerie QT2 sépare les signaux acqueux provenant de compartiments micro-anatomiques distincts. Plus spécifiquement, cet ouvrage cherche à mieux comprendre l'interdépendance des mesures de ces deux techniques dans le contexte pathologique de la sclérose en plaques (SEP), pour ensuite les appliquer à l' étude de lésions aigues de SEP. En premier lieu, des simulations ont été effectuées pour évaluer la sensibilité de chaque technique aux caractéristiques d'un modèle plus complet de la substance blanche, qui découle de résultats in vitro publiés et incorpore quatre réservoirs de magnétisation. Ensuite, la reproductibilité de chacune des techniques a été évaluée; de plus, quelques variations élémentaires des méthodes d'acquisition et d'analyse des données examinées. En dernier lieu, les deux techniques ont été utilisées in vivo afin de mesurer les changements dynamiques des lésions aigues de SEP, présentant un hyper-signal rehaussée par un agent de contraste. Les résultats des simulations démontrent d'un point de vue théorique la sensibilité et les limites de chacune de ces technique aux changements dans la substance blanche. Ces résultats apportent égalem
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Bell, David N. "Physical factors governing the aggregation of human platelets in sheared suspensions." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75873.

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The effect of shear rate on the ADP-induced aggregation of human blood platelets in flow through tubes was studied over the full physiologically significant range. The extent of single platelet aggregation at 0.2 $ mu$M ADP in citrated platelet-rich plasma, PRP, was greatest at mean tube shear rate, G = 314 s$ sp{-1}$; however, aggregate size steadily decreased from G = 39.3 to 1800 s$ sp{-1}$. At 1.0 $ mu$M ADP the rate of aggregation increased up to G = 1800 s$ sp{-1}$ where virtually no unaggregated platelets remained after 43 s of flow, although, aggregate size was still limited by shear rate. A shear-dependent delay in the onset of aggregation and an increase in collision efficiency with time suggest the existence of a time and shear-dependency in the expression of bonds mediating aggregation. Greater aggregation of platelets from female donors than male donors was due to differences in the ionized calcium concentration, (Ca$ sp{2+}$), in the plasma of donors of different hematocrit when the chelating agent citrate is used as anticoagulant. At physiological (Ca$ sp{2+}$) aggregation was much greater in heparinized and hirudinized plasma than in citrated plasma and no sex difference was present. Aggregation in whole blood was much greater than in PRP due to a shear-dependent increase in the frequency of collision between activated platelets caused by the motion of red cells.
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Carlini, Lina. "Photosensitization of InP/ZnS quantum dots for photodynamic therapy." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106430.

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Photodynamic therapy (PDT) is a treatment that makes use of light and a photosensitizing drug to destroy malignant cells. Current clinically approved drugs suffer from many limitations; the most prevalent of these is due to the absorption coefficient of human tissues in the wavelength regime where these drugs are excitable. Semiconductor quantum dots (QDs) can overcome this drawback since they can be synthesized to become excited at any wavelength. The goal of this thesis is to explore the possibility of using core/shell Indium Phosphide/Zinc Sulfide (InP/ZnS) quantum dots (QDs) for photodynamic therapy applications. Electron paramagnetic resonance (EPR) spectroscopy and colorimetric assays were used to identify the nature of toxic species produced. From these findings, the physical mechanism by which these particles produce toxic species is discussed. It was found that InP/ZnS QDs produced superoxide anions and hydroxyl radicals, the levels of which depended on the ZnS shell thickness. Furthermore, the level of cellular uptake was studied in different cell lines using confocal microscopy. It was found that InP localized in the perinuclear region of all cell lines and that B16 melanoma cells showed the most efficient levels of uptake (2.5 times greater than the uptake from KB cells). Lastly, conjugation of InP QDs to the chemotherapeutic drug doxorubicin (Dox) was studied using flow cytometry and colorimetric assays. It was found that conjugation of Dox to InP led to enhanced levels of cell death; it is proposed that this was due to more efficient drug delivery by the conjugate. In summary, photosensitization processes in InP/ZnS QDs can be exploited for PDT applications; these particles also prove to be promising as a drug delivery agent. Despite this, photophysical processes of these QDs must be further explored to ameliorate their design for PDT.
La thérapie photodynamique (TPD) est un traitement médical qui détruit les cellules cancéreuses en utilisant des photons de lumière, typiquement en forme de laser, afin d'activer des drogues photosensibles. Présentement, les médicaments approuvés pour usage clinique ont d'importantes limitations. Particulièrement, le coefficient d'absorption des tissus humains se retrouve dans la même gamme de longueur d'onde où les médicaments sont excitables; par conséquent, leur efficacité est compromise. Les nanoparticules de matériaux semi-conducteurs, appelées aussi points quantiques (PQs), ont l'habilité de surpasser cette limitation parce qu'ils peuvent être produits pour absorber la lumière à n'importe quelle longueur d'onde. L'objectif de cette thèse est donc d'évaluer la possibilité d'utiliser les PQs pour la TPD. Plus spécifiquement, les PQs composés d'un cœur de phosphure d'indium (InP) avec une coquille du sulfure de zinc (ZnS) ont été examinés. La spectroscopie par résonance paramagnétique électronique (RPE) et les tests colorimétriques ont été utilisés pour identifier la nature des espèces toxiques produites, ainsi que le mécanisme responsable de leur formation. Les résultats ont montré que les particules de InP/ZnS produisent des anions de superoxyde et des radicaux d'hydroxyle; la quantité des radicaux formés dépend de l'épaisseur de la coquille ZnS. En plus, la microscopie confocale a été utilisée pour évaluer l'ingestion intracellulaire des PQs par divers types de cellules. Ces images ont démontré que les PQs se concentrent dans le cytoplasme autour du noyau et que les cellules mélanomes de type B16 sont celles qui absorbent le plus (2.5 fois plus que les cellules KB). Finalement, les PQs ont été conjuguées à un agent chimiothérapeutique (doxorubicin (Dox)) et leur toxicité a été explorée par cytométrie en flux et des tests colorimétriques. La mort cellulaire a augmenté avec l'attachement de PQs, ce qui s'explique par une amélioration de la livraison intracellulaire de Dox. En conclusion, les PQs InP/Zn révèlent être des candidats prometteurs en tant que médicaments et agents de livraison pour la TPD, cependant certains éléments de leur structure restent à être améliorés.
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Cohalan, Claire. "Cerebral blood volume changes during human neuronal activation: a comparative study of VASO and VERVE." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66871.

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In this research, two techniques which measure hemodynamic changes during neuronal activation in humans were studied. The Vascular Space Occupancy (VASO) technique indirectly measures changes in total cerebral blood volume (CBV) by measuring the decrease in grey matter signal during activation, in images in which the blood signal is nulled. The Venous Refocusing for Volume Estimation (VERVE) technique measures changes in venous blood volume by exploiting the dependence of partially-deoxygenated blood's T2¬ on the refocusing interval τ180. Using a simultaneous visual and motor task, a (ΔCBV/CBVrest)total of 25.0 ± 13.9 % and a (ΔCBV/CBVrest)¬venous of 3.9 ± 1.6 % were measured using VASO and VERVE, respectively. Though the VASO technique has a high CNR and is simple to implement, its signal has contributions from many compartments other than grey matter. VERVE has fewer deleterious effects, but suffers from a higher power deposition. The activated regions in VERVE overlap better with BOLD activation than the VASO regions do, which, combined with VERVE's specificity to venous CBV changes, make it more appropriate in an investigation of the blood volume contribution to the BOLD signal.
Deux techniques visant à mesurer les changements de volume sanguin cérébral durant l'activité neuronale sont étudiées. La première, Vascular Space Occupancy (VASO), mesure l'augmentation de l'ensemble du sang en mesurant la baisse du signal provenant de la matière grise, dans une image où la magnétisation du sang est nulle. La deuxième, Venous Refocusing for Volume Estimation (VERVE), mesure en particulier l'augmentation du volume sanguin veineux en exploitant la dépendance du T2 du sang partiellement deoxygéné sur l'intervalle de refocalisation τ180. Avec une tâche à la fois motrice et visuelle, un (ΔCBV/CBVrepos)totale de 25,0 ± 13,9 % et un (ΔCBV/CBVrepos)¬veineux de 3,9 ± 1,6 % ont été mesurés par VASO et VERVE, respectivement. La méthode VASO est facile à instrumenter, et jouit d'un ratio contraste-bruit plus élevé que VERVE, mais plusieurs compartiments autres que la matière grise contribuent à son signal. Moins d'effets gênants contribuent au signal de VERVE, mais celui-ci souffre d'un taux de puissance déposé élevé, parfois atteignant les limites imposées par la Commission Fédérale des Communications. Le volume activé de VERVE correspond mieux que le volume activé de VASO au volume activé de BOLD. Ce fait, et celui que VERVE mesure spécifiquement le volume veineux, prônent l'utilisation de cette technique dans une analyse de la contribution du volume sanguin au signal BOLD.
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Xu, Ling Bin. "Commissioning of a GafChromic EBT film dosimetry protocol at the Ionizing Radiation Standards group of the National Research Council." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=67022.

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A GafChromic EBT film dosimetry protocol was established at the Ionizing Radiation Standards group of National Research Council. After a literature view, several aspects of EBT film dosimetry were investigated. The energy and radiation modality independence of EBT film was confirmed at the 2 % level. A calibration curve was established using a 32 point calibration curve described by a four-parameter polynomial. The darkening of EBT film is found to be significant after the first 24 hours, and up to 5 % darkening was observed over three months, which rules out the use of EBT film as an audit dosimeter. We confirmed the need for scanner uniformity correction and devised a single equation correction technique. The film homogeneity was found to be the dominant factor in dose measurement uncertainty. After establishing the film dosimetry protocol, the EBT film was used as a two-dimensional dosimeter in Monte Carlo benchmarking experiments.
Un protocol dosimétrie utilisant du film Gafchromic EBT a été établi d'en le groupe des Étalons de rayonnements ionisants du Conseil national de recherches. Après une vue de la littérature, plusieurs aspects de la dosimétrie du film EBT ont été étudiés. L'indépendance de l'énergie et le tipe de rayonnement du film EBT a été confirmé avec une precision de 2%. Une courbe d'étalonnage a été établie en utilisant une courbe d'étalonnage de 32 point décrite par un polynôme a quatre paramètres. Le noircissement du film EBT a ete jugée significative après les premières 24 heures, et jusqu'à 5% a été observé au cours d'assombrissement de trios mois, ce qui exclut l'utilisation du film EBT comme un dosimètre audit. Nous avons confirmé la nécessité de faire un correction pour l'uniformité du scanner et concu une seule equation pour la correction. L'homogénéité du film a été le facteur dominant dans l'incertitude de la mesure du dose. Après avoir établi le protocole du film, le film EBT a été utilisé comme un dosimètre à deux dimensions pour des experiences de confirmation des techniques Monte Carlo.
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Mawko, G. M. "Three-dimensional analysis of digital subtraction angiograms for stereotactic neurosurgery planning." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74238.

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Geometric and tomographic methods of reconstructing three-dimensional cerebral blood vessels from two-dimensional digital subtraction angiograms are studied experimentally.
Three-dimensional vessel geometry is reconstructed from center-line coordinates of corresponding vessel branches in both stereo and biplane angiogram pairs. The problem associated with finding corresponding vessel branches in biplane images was shown to be reduced by re-projection of stereoscopically reconstructed vessels. Results indicate that the limiting factor in reconstruction accuracy is the degree of vessel foreshortening in biplane image pairs.
An iterative algorithm ('Clean') is adapted to tomographic reconstruction of vessel cross-sections from a small number of views. Star-pattern artifacts in images initially formed by back-projection are removed by iterative deconvolution guided by 'a priori' object knowledge. This procedure is repeated for a set of two-dimensional sections that describe the three-dimensional vascular structure. Results show that there is sufficient detail in reconstructed sections to determine the location of vascular structures.
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Herrmann, Marc. "Development of a microfluidic immunoassay platform for the rapid quantification of low-picomolar concentrations of protein biomarkers." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21988.

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The sensitive and specific detection of proteins is at the center of many routine analyses in fundamental research, medical diagnosis, food quality control and environmental safety. The current gold standard for these applications remains the laborious and costly microwell plate ELISA. Over the last decade, new miniaturized devices have emerged: microfluidic systems that can drastically reduce the costs and the time of analysis. Many approaches and designs have been proposed. However, some recurrent difficulties remain that prevent the achievement of a system with the necessary balance between scientific performance, cost-effectiveness and user friendliness. These limitations include the complexity to maintain a constant flow rate in a simple and repeatable fashion, to mix solutions in a laminar flow regime, to control undesired surface effects, and to connect the chip to external pumping instruments. This thesis describes a novel microfluidic immunoassay platform that addresses the aforementioned issues while also achieving highly sensitive parallel measurements for the rapid quantification of protein biomarkers. The development of this platform followed three consecutive stages: (i) the establishment of an initial design for the simple manipulation of solutions in stop-flow mode, and the elaboration of strategies for mixing and for the simultaneous detection of parallel reactions, (ii) the introduction of the concept of Dual Network system, which removes the need for channel passivation against the non-specific adsorption of proteins, and (iii) the optimization of the critical assay parameters for the quantification of the cytokine TNF-alpha. The main attributes of the developed platform are also presented: the straightforward fabrication process, the simplified flow control, the enzymatically generated fluorescent signal, and the multi-purpose use of magnetic beads. These microbeads were utilized as functionalized substrate to capture the analyte, but also to
La détection sensible et spécifique de protéines se trouve au cœur d'analyses de routine dans la recherche fondamentale, le diagnostique médical, le contrôle qualité de la nourriture et la sûreté environnementale. Le standard actuel pour ces applications est toujours le coûteux et laborieux test ELISA en micropuits. Au cours de la dernière décennie, de nouveaux dispositifs miniaturisés ont fait leur apparition : des systèmes microfluidiques pouvant réduire de manière drastique les coûts et les temps d'analyse. Plusieurs approches et designs ont été proposés. Cependant, certaines difficultés récurrentes entravent toujours l'avènement d'un système possédant l'équilibre nécessaire entre la performance scientifique, le maintient de coûts bas, et la facilité d'utilisation. Ces limitations incluent la complixité de fixer une vitesse de flot constante de façon simple et reproductible, de mixer des solutions en régime laminaire, de contrôler les effets de surfaces indésireux, et de connecter la puce à des instruments de pompage externes. Cette thèse décrit une nouvelle plateforme d'immunoessais microfluidiques, qui adresse les problèmes mentionnés tout en réalisant des mesures hautement sensibles et en parallèle pour la quantification de biomarqueurs protéiques. Son développement a suivi trois étapes consécutives : (i) l'établissement d'un design initial pour la manipulation aisée de solutions en mode stop-flow, l'élaboration de stratégies de mixage et de détection simultanée de réactions parallèles, (ii) l'introduction du concept de système Dual Network, qui supprime la nécessité de passiver les canaux contre l'adsorption non-spécifique de protéines, et (iii) l'optimisation des paramètres critiques de l'essai pour la quantification de la cytokine TNF-alpha. Les attribues principaux de la plateforme sont également présentés : le procédé de fabrication rapide, le contrôle du flot simplifié, le signal$
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Liu, Qian. "Structural insights into apoptotic regulation by BCL-2 family." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95022.

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Myeloid cell leukemia 1 (MCL-1), an anti-apoptotic BCL-2 member, is active in the preservation of mitochondrial integrity during apoptosis. By collective data from nuclear magnetic resonance (NMR) spectroscopy and titration calorimetry, we revealed the selectivity of MCL-1 in binding BH3 ligands of interest to mammalian biology, and proved that the core domain of MCL-1 (cMCL-1) is necessary and sufficient for BH3 ligand binding. We characterized the in vitro protein-protein interaction between cMCL-1 and activated BID, which occurs in a very slow manner in solution but is otherwise similar to the interaction between cMCL-1 and BID-BH3 peptide. We also present the solution structure of complex cMCL-1:BID-BH3, which may greatly facilitate drug discovery studies of human tumor malignancies. BAK, a multi-region pro-apoptotic protein, directly mediates the mitochondrial outer membrane permeablization (MOMP). We completed a structural investigation of BAK by X-ray crystallography. We report two structures of BAK's homo-dimers, one zinc-mediated (cBAK) and one disulphide-bond-linked (cBAK-o). Their dimerizing sites locate closely at D160 and H164 in cBAK and C166 in cBAK-o, which allow them to compose a unique regulatory element to switch BAK's activity as suggested in mitochondria activity-testing assays. BAK is tightly regulated through protein-protein interactions by MCL-1. We characterize the conformational changes in BAK and MCL-1 using detergents to mimic the membrane environment, and studied their interaction in vitro. The non-ionic detergent IGEPAL and the zwitterionic detergent CHAPS have different effects on these two proteins, but both initiate the heterodimerization. The complex of MCL-1 and BAK can be disrupted by either a BID-BH3 peptide, which acts through binding to MCL-1, or a mutation in BH3 region of BAK (L78A), demonstrating the essential role of BAK's BH3 in its regulation by MCL-1. This thesis concludes with a hybrid model for BAK activation:
La protéine MCL-1 (Myeloid cell leukemia 1), qui appartient à la classe de protéines anti-apoptotiques BCL-2, joue un rôle dans le maintien de l'intégrité mitochondriale durant l'apoptose. Les résultats obtenus par résonance magnétique nucléaire (RMN) et par titrage calorimétrique, nous ont permis de mettre en évidence la sélectivité de la protéine MCL-1 pour les ligands mammifères d'interêt biologiques qui contiennent le motif BH3 et nous avons ainsi démontré que le domaine central du facteur MCL-1 (cMCL-1) est nécessaire et suffisant pour cette interaction. Nous avons caractérisé in vitro l'interaction entre le domaine cMCL-1 et le facteur activé BID; cette interaction se produit lentement en solution mais est similaire à celle observée entre le domaine cMCL-1 et le peptide BID-BH3. De plus nous avons résolu la structure du complexe cMCL-1:BID-BH3, qui est une cible potentielle qui pourrait être à la base d'un criblage d'une banque de petites molécules dans le cas de tumeurs humaines malignes. BAK, une protéine pro-apoptotic modulaire, permet la perméabilité de la membrane externe de la mitochondrie: ce mécanisme est dénommé “MOMP” pour “the mitochondrial outer membrane permeablization”. Nous avons accompli l'étude structurale de la protéine BAK par cristallographie et diffraction de rayons X. Nous présentons deux complexes de la protéine BAK: un homodimère lié par une molécule de zinc (cBAK) et une qui contient un pont disulfure (cBAK-o). Le site de dimérisation se situe proche des résidu D160 et H164 pour cBAK et C166 pour cBAK-o, ce qui leur confère un élément de régulation unique pour moduler l'activité de BAK comme suggéré dans des essais d'activité mitochondriale. La protéine BAK est finement régulée grâce à son interaction protéine-protéine avec MCL-1. Nous avons caractérisé les changements conformations des facteurs BAK et MCL-1 à l'aide de détergents pour modéliser un environnement m
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Books on the topic "Biophysics, Medical"

1

Radiation biophysics. 2nd ed. San Diego, Calif: Academic Press, 1998.

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Radiation biophysics. Englewood Cliffs, N.J: Prentice Hall, 1990.

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Alpen, Edward L. Radiation biophysics. Englewood Cliffs, N.J: Prentice-Hall, 1990.

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Tarjan, I. An introduction to biophysics with medical orientation. Budapest: Akademi Kiado, 1990.

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Luo, Liaofu. Collected works on theoretical biophysics. Hohhot, Inner Mongolia: Inner Mongolia University Press, 1997.

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Physics in medical diagnosis. London: Chapman & Hall, 1997.

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Volobuev, A. N. Osnovy medit︠s︡inskoĭ i biologicheskoĭ fiziki: Dli︠a︡ studentov, aspirantov i vracheĭ. Moskva: [Samarskiĭ Dom Pechati], 2011.

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Shung, K. Kirk. Principles of medical imaging. San Diego: Academic Press, 1992.

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1951-, Smith Michael B., and Tsui Benjamin M. W, eds. Principles of medical imaging. San Diego: Academic Press, 1992.

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Epidemiology 101. Sudbury, Mass: Jones and Bartlett Publishers, 2009.

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Book chapters on the topic "Biophysics, Medical"

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ter Haar, Gail R. "Ultrasonic Biophysics." In Physical Principles of Medical Ultrasonics, 349–406. Chichester, UK: John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470093978.ch12.

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Ohki, Kazuo, and Hidetake Miyata. "Global Environment and Biophysics." In Biological and Medical Physics, Biomedical Engineering, 159–66. Tokyo: Springer Japan, 2018. http://dx.doi.org/10.1007/978-4-431-56841-4_8.

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Needham, Charles E., Leanne R. Young, and Howard R. Champion. "Blast Physics and Biophysics." In Operational and Medical Management of Explosive and Blast Incidents, 19–33. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-40655-4_2.

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Gauduel, Yann A. "Laser-Plasma Accelerators Based Ultrafast Radiation Biophysics." In Biological and Medical Physics, Biomedical Engineering, 19–50. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31563-8_2.

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Vedda, Anna, and Irene Villa. "Medical Applications of Nanomaterials." In NATO Science for Peace and Security Series B: Physics and Biophysics, 369–86. Dordrecht: Springer Netherlands, 2017. http://dx.doi.org/10.1007/978-94-024-0850-8_18.

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Vlk, D., V. Mornstein, and C. J. Caruana. "A Medical Biophysics Conceptual Base for Medical / Healthcare / Technology Students at the Department of Biophysics, Faculty of Medicine, Masaryk Uni., Brno." In IFMBE Proceedings, 54–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03893-8_16.

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Leondes, Cornelius T. "Digital Halftoning Algorithms for Medical Imaging." In Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems, 127–92. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/0-306-48329-7_4.

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Leondes, Cornelius T. "Neural Network Techniques: Utilization in Medical Prognosis." In Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems, 1030–54. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/0-306-48329-7_32.

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Williams, Mark C., and L. James Maher. "Introduction to Biophysics of DNA–Protein Interactions: From Single Molecules to Biological Systems." In Biological and Medical Physics, Biomedical Engineering, 3–8. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-92808-1_1.

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Leondes, Cornelius T. "Mean Curvature Flows, Edge Detection, and Medical Image Segmentation." In Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems, 856–70. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/0-306-48329-7_24.

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Conference papers on the topic "Biophysics, Medical"

1

Kralova, Eva, Elena Ferencova, and Michal Trnka. "SEMESTER PROJECTS IN MEDICAL BIOPHYSICS PROMOTE ACTIVE LEARNING." In International Conference on Education and New Learning Technologies. IATED, 2017. http://dx.doi.org/10.21125/edulearn.2017.0752.

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Kralova, Eva, and Elena Ferencova. "A BETTER UNDERSTANDING OF CLINICAL APPLICATIONS OF MEDICAL BIOPHYSICS THROUGH SEMESTER PROJECTS?" In 10th annual International Conference of Education, Research and Innovation. IATED, 2017. http://dx.doi.org/10.21125/iceri.2017.1964.

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Haverlíková, Viera. "FIRST EXPERIENCE WITH E-LEARNING COURSE SUPPORTING THE PRACTICAL TRAINING IN MEDICAL BIOPHYSICS." In International Conference on Education and New Learning Technologies. IATED, 2017. http://dx.doi.org/10.21125/edulearn.2017.2531.

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Kordek, David, Martin Kopecek, and Petr Voda. "Medical biophysics as a combination of the classic educational method and e-learning." In 2017 Federated Conference on Computer Science and Information Systems. IEEE, 2017. http://dx.doi.org/10.15439/2017f369.

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Kalashnikova, S. A. "Organization of independent work in practical classes in the discipline "Biophysics" at a medical university." In SCIENCE OF RUSSIA: GOALS AND OBJECTIVES. L-Journal, 2020. http://dx.doi.org/10.18411/sr-10-12-2020-04.

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Haverlíková, Viera. "DEVELOPMENT OF SCIENCE PROCESS SKILLS HAS TO BE AN INTEGRAL PART OF EDUCATION IN MEDICAL BIOPHYSICS." In International Conference on Education and New Learning Technologies. IATED, 2017. http://dx.doi.org/10.21125/edulearn.2017.2493.

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Hadjimitova, Vera, Nadya Hristova-Avakumova, Lili Atanasova, and Ivan Antonov. "How to encourage medical students to learn physics and biophysics – A task with many possible solutions." In 10th Jubilee International Conference of the Balkan Physical Union. Author(s), 2019. http://dx.doi.org/10.1063/1.5091413.

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Trnka, Michal. "THEORETICAL BACKGROUND FOR THE CREATION OF MULTIMEDIA MODELS AND ANIMATIONS FOR THE UNIVERSITY TEACHING OF MEDICAL BIOPHYSICS." In 11th annual International Conference of Education, Research and Innovation. IATED, 2018. http://dx.doi.org/10.21125/iceri.2018.0778.

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Trnka, Michal, and Eva Kralova. "NEWS IN DIDACTIC TECHNOLOGIES USED IN THE TEACHING OF MEDICAL BIOPHYSICS IN THE CONDITIONS OF COVID19 PANDEMIC." In 13th annual International Conference of Education, Research and Innovation. IATED, 2020. http://dx.doi.org/10.21125/iceri.2020.1458.

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Tomilov, Sergey, Mikhail Tarabrin, Vladimir Lazarev, Valery Karasik, and Valery Tuchin. "Broadband tunable mid-IR Cr2+:CdSe lasers for medical applications." In Saratov Fall Meeting 2017: Fifth International Symposium on Optics and Biophotonics: Laser Physics and Photonics XIX; Computational Biophysics and Analysis of Biomedical Data IV, edited by Vladimir L. Derbov and Dmitry E. Postnov. SPIE, 2018. http://dx.doi.org/10.1117/12.2315035.

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Reports on the topic "Biophysics, Medical"

1

Engheta, Nader, Jr Pugh, Rowe Edward N., Lynch Mickey, Tyo Eileen, and J. S. Polarization-Difference Imaging: Biophysical Mechanisms and Engineering Applications to Visibility Enhancement in Scattering Media. Fort Belvoir, VA: Defense Technical Information Center, July 1993. http://dx.doi.org/10.21236/ada283458.

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Summaries of research projects for fiscal years 1996 and 1997, medical applications and biophysical research. Office of Scientific and Technical Information (OSTI), February 1998. http://dx.doi.org/10.2172/573260.

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