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Dissertations / Theses on the topic 'Bioquimica (toxicidade)'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Guelfi, Marieli [UNESP]. "Mecanismos de toxicidade do fipronil em hepatócitos isolados de rato." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/126505.

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Made available in DSpace on 2015-08-20T17:10:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-03-03. Added 1 bitstream(s) on 2015-08-20T17:26:02Z : No. of bitstreams: 1 000843974.pdf: 2232932 bytes, checksum: d71102c081901322bd4ba52e2d8d373f (MD5)<br>O fipronil é um inseticida de amplo-espectro de ação utilizado extensivamente para o controle de pragas. Existem relatos descritos na literatura de intoxicação em animais e humanos provocada pelo composto, causando até a morte. Assim, torna-se bastante relevante elucidar os mecanismos de hepatotoxicidade do inseticida para o auxílio no

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Guelfi, Marieli. "Mecanismos de toxicidade do fipronil em hepatócitos isolados de rato /." Dracena, 2015. http://hdl.handle.net/11449/126505.

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Orientador: Fábio Erminio Mingatto<br>Banca: Flavia Thomas Verechia Pereira<br>Banca: Ana Angélica Henrique Fernandes<br>Resumo: O fipronil é um inseticida de amplo-espectro de ação utilizado extensivamente para o controle de pragas. Existem relatos descritos na literatura de intoxicação em animais e humanos provocada pelo composto, causando até a morte. Assim, torna-se bastante relevante elucidar os mecanismos de hepatotoxicidade do inseticida para o auxílio no tratamento em caso de intoxicação por parte dos mamíferos. O objetivo desse estudo foi caracterizar o mecanismo de toxicidade do fipr

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Fiuza, Tiago da Luz. "Efetividade do (PhSe)2 em proteger contra a toxicidade do HgCl2." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/11228.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Mercury (Hg) is a non-essential metal without biological function and also an environmental pollutant originating from various sources, especially from areas of mineral exploration and intense industrial activity. It is well known that Hg has a high affinity for thiol groups (SH) causing several biochemical changes that induce oxidative stress. On the other hand, selenium (Se) is an essential trace element involved in many processes in metabolism, especially which are related to antioxidant defense system. The diphenyl diselenide (

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Tavares, Marco Aurélio [UNESP]. "Mecanismos de toxicidade dos metabólitos do fipronil, dessulfinil e sulfona, em mitocôndrias isoladas de fígado de rato." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/136037.

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Made available in DSpace on 2016-03-07T19:20:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-11-05. Added 1 bitstream(s) on 2016-03-07T19:24:50Z : No. of bitstreams: 1 000859360.pdf: 1034814 bytes, checksum: c0a4def8be0c2f45d09cbd7c089d88da (MD5) Bitstreams deleted on 2016-03-28T13:37:51Z: 000859360.pdf,. Added 1 bitstream(s) on 2016-03-28T13:38:52Z : No. of bitstreams: 1 000859360.pdf: 1034815 bytes, checksum: 0e2a44e2cca5e564a6825b47d8322e41 (MD5)<br>O fipronil é um inseticida amplamente utilizado para controlar pragas nas plantações e em animais. Existem relatos de intoxicação

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Tavares, Marco Aurélio. "Mecanismos de toxicidade dos metabólitos do fipronil, dessulfinil e sulfona, em mitocôndrias isoladas de fígado de rato /." Dracena, 2015. http://hdl.handle.net/11449/136037.

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Orientador: Fábio Erminio Mingatto<br>Banca: Daniel Nicodemo<br>Banca: Sérgio Diniz Garcia<br>Resumo: O fipronil é um inseticida amplamente utilizado para controlar pragas nas plantações e em animais. Existem relatos de intoxicação devido à exposição de fipronil em mamíferos e o fígado é um alvo potencial. No presente estudo, foram avaliados os efeitos dos metabólitos do fipronil, fipronil dessulfinil e fipronil sulfona sobre a bioenergética, produção de espécies reativas de oxigênio e efluxo de cálcio em mitocôndrias isoladas de fígado de rato. O fipronil dessulfinil (5 a 25 μM) inibiu o esta

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Lima, Jailma Almeida de. "An?lise toxicol?gica in vitro e in vivo de uma fucana antitromb?tica da alga marrom Spatoglossum schd?ederi." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12548.

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Made available in DSpace on 2014-12-17T14:03:31Z (GMT). No. of bitstreams: 1 JailmaAL.pdf: 4054706 bytes, checksum: f46f1a4accf9845bb01d4688f7c0745c (MD5) Previous issue date: 2009-06-18<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Fucan is a term used to denominate a family of sulfated polysaccharides rich in L-fucose. They are extracted mainly from the extracellular matrix of brown algae and echinoderms. The brown alga Spatoglossum schr?ederi (Dictyotaceae) has three heterofucans named A, B and C. Our research group have been extracted non anticoagulant heterofucan fro

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Sousa, Daniele de Oliveira Bezerra de. "Soyatoxina-2 - uma nova toxina de sementes de soja: aspectos estruturais, do mecanismo de ação e efeitos biológicos." reponame:Repositório Institucional da UFC, 2006. http://www.repositorio.ufc.br/handle/riufc/10425.

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SOUSA, D. O. B. Soyatoxina-2 - uma nova toxina de sementes de soja: aspectos estruturais, do mecanismo de ação e efeitos biológicos. 2006. 160 f. Tese (Doutorado em Bioquímica) Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2006.<br>Submitted by Francisco Lacerda (lacerda@ufc.br) on 2014-11-25T17:26:09Z No. of bitstreams: 1 2006_tese_dobsousa.pdf: 1161474 bytes, checksum: 270f28e9264a0910e54e2dbf9bc51c3e (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa(jairo@ufc.br) on 2015-01-09T16:49:52Z (GMT) No. of bitstreams: 1 2006_tese_dobsousa.pdf: 1161474 bytes, che

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Cruz, Marina Sampaio de Menezes. "Investiga??o da toxicidade gen?tica de produtos naturais atrav?s de bioensaios de curta dura??o." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20332.

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Vanderlei, Edfranck de Sousa Oliveira. "Atividades antiviral e anti-inflamatória de uma fração polissacarídica sulfatada da alga marinha vermelha Gracilaria birdiae (Plastino e Oliveira)." reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/10467.

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VANDERLEI, E. S. O. Atividades antiviral e anti-inflamatória de uma fração polissacarídica sulfatada da alga marinha vermelha Gracilaria birdiae (Plastino e Oliveira). 2012. 141 f. Tese (Doutorado em Bioquímica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2012.<br>Submitted by Francisco Lacerda (lacerda@ufc.br) on 2014-12-03T12:19:08Z No. of bitstreams: 1 2012_tese_esovanderlei.pdf: 5817978 bytes, checksum: dc9dd25d9df39cef6cafbcd2ab3bab3d (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa(jairo@ufc.br) on 2015-01-16T21:03:57Z (GMT) No. of bitstreams: 1 2

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Silva, Márcia Rósula Poetini. "Efeito protetor flavonoide hesperidina sobre a toxicidade induzida pela exposição aguda ao ferro em Drosophila melanogaster." Universidade Federal do Pampa, 2017. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/1556.

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Submitted by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-06-05T14:11:26Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) MARCIA ROSULA POETINI SILVA.pdf: 1891478 bytes, checksum: e4874e22f3dbc89ee3033d4701e4a8a2 (MD5)<br>Approved for entry into archive by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-06-05T14:11:58Z (GMT) No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) MARCIA ROSULA POETINI SILVA.pdf: 1891478 bytes, checksum: e4874e22f3dbc89ee3033d4701e4a8a2 (MD5)<br>Made av

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Wagner, Caroline. "Estudo de mecanismos de toxicidade do metilmercúrio: papel protetor de flavonóides." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/4419.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Methylmercury (MeHg) is an important environmental toxicant that may cause irreversible neurobehavioral and neuropsychological disorders in humans and experimental animals. The major mechanisms of MeHg-induced toxicity currently being explored are the disruption of intracellular calcium homeostasis, the induction of oxidative stress, inhibition of neuronal Na+/K+ -ATPase activity and change the status of antioxidant systems. In addition, recent data reported the involvement of MeHg toxicity with damage in thioredoxin system. On the

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Quinderé, Ana Luíza Gomes. "Propriedades na nocicepção e na inflamação de uma fração polissacarídica sulfatada da alga marinha Acanthophora muscoides." reponame:Repositório Institucional da UFC, 2011. http://www.repositorio.ufc.br/handle/riufc/10464.

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QUINDERÉ, A. L. G. Propriedades na nocicepção e na inflamação de uma fração polissacarídica sulfatada da alga marinha Acanthophora muscoides. 2011. 81 f. Dissertação (Mestrado em Bioquímica) - Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2011.<br>Submitted by Francisco Lacerda (lacerda@ufc.br) on 2014-10-06T20:17:11Z No. of bitstreams: 1 2011_dis_algquinderé.pdf: 2652696 bytes, checksum: 3ea18d2c3a2e31c663a80ef68b105b24 (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa(jairo@ufc.br) on 2015-01-16T20:24:50Z (GMT) No. of bitstreams: 1 2011_dis_algquinderé.pdf

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Muro, Marilena A. de. "Bacillus cereus : caracterização bioquimica e sorologica e avaliação da toxicidade de cepas isoladas de alimentos envolvidos ou não em casos de intoxicação alimentar." [s.n.], 1988. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256583.

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Orientador: Fumio Yokoya<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-07-16T10:31:41Z (GMT). No. of bitstreams: 1 Muro_MarilenaA.de_M.pdf: 7710268 bytes, checksum: 8eea55ead2d5af0de84a4ceefb712ae7 (MD5) Previous issue date: 1988<br>Resumo: Bacilus cereus foram isolados em MYP-ágar, a partir de alimentos envolvidos ou não em casos de intoxicação alimentar, sendo as colônias presuntivas identificadas pela determinação das seguintes propriedades; características morfológicas da célula vegetativa e esporân

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Gorssi, Jenifer Carvalho. "Avaliação da toxicidade de tiossemicarbazonas derivadas de benzaldeído, acetofenona e benzofenona frente a larvas de Aedes aegypti." Universidade Federal de Juiz de Fora - Campus Avançado de Governador Valadares, 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/6830.

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Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-06-12T14:03:58Z No. of bitstreams: 1 jenifercarvalhogorssi.pdf: 6998133 bytes, checksum: f49277dca971587203cbebb23396270d (MD5)<br>Rejected by Adriana Oliveira (adriana.oliveira@ufjf.edu.br), reason: on 2018-06-12T14:07:12Z (GMT)<br>Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-06-12T14:09:43Z No. of bitstreams: 1 jenifercarvalhogorssi.pdf: 6998133 bytes, checksum: f49277dca971587203cbebb23396270d (MD5)<br>Rejected by Adriana Oliveira (adriana.oliveira@ufjf.edu.br), reason: on 2018-06-12T14:27:20Z (GMT)<br>Submitte

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Pedroso, Taíse Fonseca. "Avaliação da toxicidade do chumbo em parâmetros bioquímicos e comportamentais: efeito preventivo do zinco e n-acetilcisteína." Universidade Federal de Santa Maria, 2017. http://repositorio.ufsm.br/handle/1/12772.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Lead (Pb) is a toxic metal without biological function, which can cause various undesirable changes in organism. Developing animals are more sensitive to external aggressions, and exposure to Pb may cause pronounced and even irreversible damage. Studies show detoxifyng action by zinc chloride (ZnCl2) and N-acetylcysteine (NAC), suggesting same protective effect against intoxication with Pb. Therefore, we investigated the toxic effect of lead acetate (AcPb) on biochemical and behavioral parameters, in developing animals, and

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Acker, Carmine Inês. "Efeitos farmacológicos do disseleneto de difenila em modelos de toxicidade induzida por organofosforados em ratos." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/4461.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Pesticides are substances used in agricultural areas and public health programs to control pests and disease vectors. Among pesticides, organophosphates (OPs) are considered the most toxic to vertebrates. Diphenyl diselenide [(PhSe)2] is an organoselenium compound that presents pharmacological activities, among that the antioxidant effect. Therefore, the aim of this study was to evaluate the pharmacological effects of (PhSe)2 in acute models of toxicity induced by chlorpyrifos (CPF) and acephate (AC) in rats, as well as to investig

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Corte, Cristiane Lenz Dalla. "Efeitos de compostos orgânicos de selênio frente à toxicidade induzida por glutamato e metilmercúrio." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/4455.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Organoselenium compounds have been proposed as potential pharmacological agents in the treatment of diseases associated with the oxidative stress. Particularly, ebselen and diphenyl diselenide has been demonstrated as potential antioxidant agents in a variety of experimental models. Thus, the aims of the present study were: to evaluate the effect of ebselen and diphenyl diselenide, as well as, their combination with guanosine on the oxidative stress induced by glutamate in different regions of rat brains (article 1), to test the ef

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Roos, Daniel Henrique. "Mecanismos de captação e toxicidade do metilmercúrio: Envolvimento do sistema glutamatérgico e do cálcio em fatias e mitocôndrias de ratos." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/4446.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Methylmercury (MeHg) is a highly toxic environmental contaminant that can be accumulated on several tissues, inducing cellular dysfunction on various organs, especially in the central nervous system (CNS). The mechanisms involved in the uptake, accumulation and toxicity of mercury (Hg) remain unclear. However, it has been suggested that the neurotoxicity mediated by MeHg induces changes in both glutamatergic system and calcium homeostasis. Indeed, the literature reports that calcium per se is able in inducing cellular damage. Thus,

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Brandão, Ricardo. "Efeito do disseleneto de difenila sobre a toxicidade induzida por cloreto de mercúrio em camundongos." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/4407.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Mercury is a metal without physiological functions in human body and is toxic to human beings. This metal has many applications in industry and, therefore it is very important in occupational and environmental exposure. The toxicity of mercury depends on the form of the metal and can affect several organs, such as brain, kidney and liver. In addition, mercury can cause alteration in hematological and immunological systems. The oxidative stress seems to be involved in toxicity induced by mercury, since this metal may cause an increa

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Bueno, Diones Caeran. "TOXICIDADE DE ORGANOCALCOGÊNIOS E SEUS MECANISMOS ATRAVÉS DA EXPRESSÃO GÊNICA EM LEUCÓCITOS HUMANOS." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/11232.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Selenium (Se) is an essential micronutrient present in selenoproteins on living beins, in the form of the amino acid selenocysteine and selenomethionine. Chemically related to Se, tellurium (Te) has no biological function in mammals, however, organic Te compounds showed up as good antioxidant agents. Although ebselen (Ebs), diphenyl diselenide [(PhSe)2] and diphenyl ditelluride [(PhTe)2] present antioxidant properties via their glutathione peroxidase (GPx) mimetic activity, these compounds exhibit toxic effects at high concentrat

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Menezes, Charlene Cavalheiro de. "Efeito do disseleneto de difenila sobre a toxicidade induzida por herbicidas em peixes." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4465.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Environmental contamination caused by frequent use of herbicides in agriculture has increased in last decades. The quinclorac and clomazone herbicides are widely used in agriculture, which can cause contamination to organisms, such as fish. However, it is necessary studies in order to minimize the toxic effects of these compounds on aquatic ecosystems. Micronutrients such as selenium, which is essential in the nutrition of fish, may have antioxidant functions against oxidative damage caused by herbicides. The objective of this stud

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Fonseca, Mariana Mesquita. "Toxicidade do HgCl2 em ratas Wistar analisadas 12 e 48 horas após a exposição: possível efeito preventivo do zinco." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/11246.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Mercury is a metal without any biological function. The exposure to mercury in any of different chemical forms can induce toxic effects on living organisms. This toxicity is commonly attributed to the high affinity that this metal has for sulfhydryl groups (SH) and oxidative stress induction. Zinc is an essential metal important in many biochemical and cellular functions, and stands out among the compounds studied for preventing the damage caused by toxic metals such as mercury. Recently we verify the effectiveness of pre-treatment

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Oliveira, Vitor Antunes de. "Toxicidade do mercúrio em ratas virgens, gestantes e lactantes: efeito protetor do zinco e da N-acetilcisteína." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/4501.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Mercury (Hg) is a divalent metal found liquid at room temperature without biological functions and anthropogenically released in industrial, agricultural activities and burning of fossil fuels. Toxic effects caused by exposure to this metal are related to the interaction of different biochemical processes due to its affinity for sulfhydryl groups (SH). This damage depends on the time of exposure and the development period in which the individuals are exposed. Thus, the aim of this study was to evaluate the effects of a single subcu

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Comparsi, Bruna. "Efeitos da n-acetilcisteína sobre a toxicidade do ditelureto de difenila no encéfalo de camundongos." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4496.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The diphenyl ditelluride (PhTe)2 is one of the most toxic organic compounds of tellurium which can make their use unsafe. The mechanism(s) involved in (PhTe)2 toxicity is(are) elusive, but thiol oxidation of critical proteins are important targets. Consequently, the possible remedy of its toxicity by thiol-containing compounds is of experimental and clinical interest. Therefore, this study aimed to evaluate the toxicity of in vivo exposure to (PhTe)2 from oxidative stress biomarkers and behavioral parameters in adult mice and the

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Okamoto, Débora Noma. "Efeito de substâncias químicas de uso laboratorial sobre Drosophila melanogaster (Diptera - Drosophilidade) do ponto de vista bioquímico e fenotípico /." São José do Rio Preto : [s.n.], 2007. http://hdl.handle.net/11449/87569.

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Resumo: A presença de resíduos químicos no ambiente afeta todo o ecossistema. Uma das técnicas empregadas para o estudo dos efeitos tóxicos dos resíduos químicos é o biomonitoramento, que utiliza como modelos organismos vivos, entre eles os insetos. Um dos gêneros utilizados é a Drosophila, em particular a espécie D. melanogaster de distribuição cosmopolita. É um organismo geneticamente bem explorado, de fácil manutenção e rápido ciclo biológico, que após o seqüenciamento completo de seu genoma revelou homologia de 60% de seus genes com os genes de doenças humanas. Entre as substâncias química

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Barbosa, Filho Valter Menezes. "Avaliação do potencial antioxidante e antibacteriano de Anacardium microcarpum e sua toxicidade em diferentes modelos biológicos in vitro." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4490.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Oxidative stress reflects an imbalance between the systemic manifestation of reactive species and a biological system s ability to readily detoxify the reactive intermediates or to repair the resulting damage. This condition may facilitate the onset of various pathological processes, including infections. Anacardium microcarpum is a native species from the Northeast Brazil, used in folk medicine as a tonic for the treatment of inflammation, rheumatism, tumor, and infectious diseases. However, there is no information in the litterat

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ROCHA, Thiago Lopes. "Biomarcadores comportamentais, histopatológicos e proteômicos da toxicidade aguda da formulação comercial do herbicida glifosato em poecilia reticulata." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tde/1266.

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Made available in DSpace on 2014-07-29T15:16:32Z (GMT). No. of bitstreams: 1 Dissertacao mestrado Thiago Rocha.pdf: 3202693 bytes, checksum: 0519000d8f7c06ef3d8a404097ad8a82 (MD5) Previous issue date: 2012-02-29<br>The mechanism of acute toxicity of the commercial formulation glyphosate, Roundup Transorb® (RDT), was investigated in the guppy (Poecilia reticulata) gills using proteomic technologies associated with analyses of histopathological indexes (HI´s), followed by quantification of histopathological lesions of the gills. Additionally, the present study describes a protocol for the anal

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Chagas, Pietro Maria. "AVALIAÇÃO IN VITRO E IN VIVO DA TOXICIDADE DO COMPOSTO 2,2 -DISSELENETO DE DITIENILA EM RATOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/11218.

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Fundação de Amparo a Pesquisa no Estado do Rio Grande do Sul<br>The compound 2,2 -dithienyl diselenide (DTDS), an organoselenium compound with thiophene moieties, has been proven to be a promising antioxidant in vitro and in vivo, as well as an antifungal and antimicrobial agent. However, its toxicity, an important point to be investigated, has not been evaluated. The objective of this study was to evaluate whether DTDS has potential toxicity in vitro or in vivo. For this reason, sulfhydryl enzyme activities, such as δ-aminolevulinic acid dehydratase (δ-ALA-D) and Na+, K+-ATPase were assessed

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Pereira, Valeska Santana de Sena. "Derivados de 2-hidr?xi-3-anilino-1,4-naftoquinona: atividade antiplasmodial in vitro, toxicidade e interfer?ncia na bioss?ntese de isopren?ides." PROGRAMA DE P?S-GRADUA??O EM BIOQU?MICA, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/21435.

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Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-10-11T22:26:01Z No. of bitstreams: 1 ValeskaSantanaDeSenaPereira_TESE.pdf: 4424545 bytes, checksum: 27d11137997bb962be78ddc99763e2fe (MD5)<br>Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-10-17T22:34:42Z (GMT) No. of bitstreams: 1 ValeskaSantanaDeSenaPereira_TESE.pdf: 4424545 bytes, checksum: 27d11137997bb962be78ddc99763e2fe (MD5)<br>Made available in DSpace on 2016-10-17T22:34:42Z (GMT). No. of bitstreams: 1 ValeskaSantanaDeSenaPereira_TESE.pdf: 4424545 bytes, checksum: 27d11

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Cattaneo, Roberta. "Parâmetros toxicológicos em carpas (Cyprinus carpio) expostos a uma formulação comercial de clomazone (gamit®)." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4435.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Commercial formulations of the herbicide clomazone have been widely used in agriculture and fish farming to control weeds. Fish can be affected when the water reaches the drainage waterways, causing an imbalance in the aquatic ecosystem. In order to evaluate a possible contamination, we determined LC50 (96h) using a commercial formulation containing clomazone (Gamit®). We verified the metabolic, enzymatic, and genotoxic parameters as well as the oxidative stress in juvenile carp (Cyprinus carpio). Firstly, in order to determine the

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Fantinel, Mara Rejane. "EFEITO in vitro DE Paullinia cupana NO METABOLISMO OXIDATIVO DE ESPERMATOZÓIDES HUMANOS EXPOSTOS AO CLORETO DE METILMERCÚRIO." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11188.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Investigations suggests that methylmercury (MeHg) toxicitiy is related to oxidative stress promotion caused by lipid peroxidation of cell membranes as well as genotoxicity. The methylmercury (MeHg) exposition causes production of adverse effects as deterioration of semen quality, testicular degeneration, and male reproductive failure. Since human sperm is a vulnerable cell investigations analyzing the antioxidant protection of plant extracts on MeHg exposition is relevant. Among Brazilian food supplements we found guaraná (Paullini

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Roman, Silvane Souza. "Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4425.

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It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics of organotellurium compounds, such as lipid solubility and molecular weight that facilitate the cross placental barrier, toxicological studies should be conducted to verify the effects of these compounds on intrauterine development in experimental models. Furthermore, organotellurium compounds have been reported as a promising alternative in health by showing pharmacol

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Ineu, Rafael Porto. "Atividade antioxidante do e-1,1-metiltio-selenofenil-2-pirrolidinona-hepteno: um composto orgânico de selênio com baixa toxicidade." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/11170.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The objective of this work was to evaluate the antioxidant activity of (E)-1-(1-(methylthio)-1-selenopheny) hept-1-en-2-yl) pyrrolidin-2-one: an organoselenium compound with low toxicity (compound 1). A number of parameters were examined in brain, liver and plasma of rats and mice as indicators of toxicity, including reactive species to the thiobarbituric acid levels, ascorbic acid content, δ-aminolevulinate dehydratase and catalase activity, AST, ALT, urea and creatinine levels. Ours experiments demonstrated that in vitro, compo

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Dobrzanski, Tatiane. "Sistema de respostas de Bacillus sp. à toxicidade induzida pelo herbicida Callisto e princípio ativo." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2015. http://tede2.uepg.br/jspui/handle/prefix/941.

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Made available in DSpace on 2017-07-21T19:59:47Z (GMT). No. of bitstreams: 1 Tatiane Dobrzanski.pdf: 2071508 bytes, checksum: e3c3a02783ca0c1929ed8b2a83555230 (MD5) Previous issue date: 2015-02-25<br>Excessive use of herbicides for weed control in agriculture causes a selective pressure on soil microbiota and waters near application area, changing environmental balance. Some microorganisms have developed metabolic pathways for degradation of these xenobiotics, although tolerance and degradation processes can generate free radicals and affect survival. This study aimed to analyze the system o

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Sudati, Jessie Haigert. "Avaliação do potencial terapêutico da Valeriana officinalis e do disseleneto de difenila frente à toxicidade induzida por rotenona em Drosophila melanogaster." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/4452.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Among various antioxidant therapeutic applications, neuroprotective action is highlighted sinceoxidative stress is recognized as one of the events involved in cell damage which occur in most of neurological disorders, including Parkinson s disease (PD). Consequently, the search for natural and/or synthetic antioxidants which may be effective in the treatment of neurological disorders has grown over the past years. In this context, several studies have shown the antioxidant potential of selenium organic compound diphenyl diselenid

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Aguiar, ValÃria Cavalcanti de. "Aspectos bioquÃmicos, toxicolÃgicos e alergÃnicos do lÃtex da planta Calotropis procera (Ait.) R. BR." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=394.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>O lÃtex da planta lactÃfera Calotropis procera (Ait.) R. Br. Ã um composto biologicamente ativo importante que apresenta propriedades relevantes como as atividades antiinflamatÃria e antidiarrÃica, embora jÃ tenha sido previamente mostrado que esse lÃtex produz efeitos tÃxicos considerÃveis em animais. Um outro fato Ã que nÃo Ã sabido, ainda, se as proteÃnas do lÃtex de C. procera produzem efeitos alergÃnicos, assim como as proteÃnas do lÃtex de Hevea brasiliensis. O potencial do lÃtex como um fÃrmaco, por essa razÃo, de

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Vanderlei, Edfranck de Sousa Oliveira. "Atividades antiviral e anti-inflamatÃria de uma fraÃÃo polissacarÃdica sulfatada da alga marinha vermelha Gracilaria birdiae (Plastino e Oliveira)." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8334.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>MolÃculas bioativas extraÃdas a partir de algas marinhas, tais como os polissacarÃdeos sulfatados,vÃm se destacando como possuidores de diversas atividades biolÃgicas. Este estudo teve como objetivo avaliar as atividades antiviral e anti-inflamatÃria de uma fraÃÃo polissacarÃdica sulfatada da alga marinha Gracilaria birdiae. Os polissacarÃdeos sulfatados totais (PST) foram extraÃdos por digestÃo enzimÃtica e em seguida, fracionados em coluna de DEAE-celulose,

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Toni, Cândida. "Respostas bioquímicas em carpas (Cyprinus carpio) expostas ao fungicida tebuconazole (folicur® 200 ec)." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/11132.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The intensive use and/or inadequate management of pesticides have led to contamination of the aquatic ecosystem, reaching the biota living there, including the fish. Pesticides can affect toxicological parameters these animals, harming their survival. In this way, the aim this study has to evaluate biochemistry changes in carps (Cyprinus carpio) after exposure to a commercial formulation of the fungicide tebuconazole (Folicur®). At first, we performed a test of acute toxicity to determine the LC50 (96h) of tebuconazole for C. car

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Alves, Francisca das Chagas de Sousa. "AvaliaÃÃo do potencial antimicrobiano de infusÃes de folhas de cajueiro (Anacardium occidentale Lin) frente a bactÃria Streptococcus mutans." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7804.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O cultivo de Anacardium occidentale Lin, mais conhecido popularmente como cajueiro, Ã uma das atividades agropecuÃrias mais importantes do Nordeste brasileiro. Ã utilizada na medicina tradicional para fins terapÃuticos, incluindo atividade antimicrobiana. O objetivo do presente trabalho foi avaliar o potencial antimicrobiano da infusÃo de folhas de cajueiro em diferentes horÃrios de coleta frente Ã bactÃria Streptococcus mutans e analisar o potencial tÃxico e citotÃxico das infusÃes nas concentraÃÃes utilizadas. A Concentr

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Bem, Andreza Fabro de. "Disseleneto de difenila: Um organocalcogênio com baixa toxicidade em não roedores e importantes propriedades anti-aterogênicas em modelos in vivo e in vitro." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/4444.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Atherosclerosis is a chronic inflammatory condition associated with an overproduction of oxidant species. Since low density lipoprotein (LDL) oxidation plays a key role in the pathogenesis of atherosclerosis, antioxidants that can inhibit this oxidative process might be useful in preventing atherosclerosis-related pathological conditions, such as cardiovascular diseases and stroke. Here, we investigated the potential toxicological effects and the anti-atherogenic properties of diphenyl diselenide (PhSe)2, a simple organoselenium co

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FARIA, Joana Cristina Neves de Menezes. "Avaliação histopatológica, histoquímica e morfométrica dos efeitos da toxicidade aguda do herbicida roundup® nas brânquias e no fígado do peixe Poecilia vivipara." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1249.

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Made available in DSpace on 2014-07-29T15:16:29Z (GMT). No. of bitstreams: 1 joana c n de m faria - dissertacao.pdf: 692068 bytes, checksum: 9ce1455900ab8ef0aa8d6ecf07c0fa97 (MD5) Previous issue date: 2009-05-20<br>The indiscriminate use of agricultural pesticides, which contaminate the soil, water, and human beings, has become a problem that causes great concern nowadays. We studied the acute toxic effect of the herbicide Roundup® on animal behavior, tissue, and cells of the neotropical fish species Poecilia vivipara gills and liver in order to determine and compare their histoarchitecture,

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Salgueiro, Andréia Caroline Fernandes. "Plantas medicinais utilizadas por pessoas com Diabetes mellitus controlam o estresse oxidativo e apresentam baixa toxicidade: avaliação in silico, in vitro e in vivo da “Pata-de-vaca” e “Macela”." Universidade Federal do Pampa, 2017. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/1671.

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Submitted by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-06-13T17:39:04Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) ANDRÉIA CAROLINE FERNANDES SALGUEIRO.pdf: 5179931 bytes, checksum: b1e888ee98755fdef5badebb2b78a8a0 (MD5)<br>Approved for entry into archive by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2017-06-13T17:39:20Z (GMT) No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) ANDRÉIA CAROLINE FERNANDES SALGUEIRO.pdf: 5179931 bytes, checksum: b1e888ee98755fdef5badebb2b78a8a

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Conterato, Greicy Michelle Marafiga. "Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4445.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential for the antioxidant defense and cellular redox control. In our previous study, it was showed that cytosolic renal TrxR1 activity of rats increased after acute and long-term exposure to Pb and this was the only parameter that changed after both exposures to low Pb doses. Then, it was suggested that TrxR1 could operate in the early defense

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Pinho, Francisca Valéria Soares de Araújo. "MECANISMOS DE TOXICIDADE DE Duguetia furfuraceae A. St.-Hill NO MODELO DE Drosophila melanogaster E AVALIAÇÃO DO POTENCIAL ANTIFÚNGICO." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4497.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Duguetia furfuracea is a common shrub from Brazilian cerrado areas, known as "ata brava", often used as a medicinal plant especially in treatment of renal colic and rheumatism. However, pharmacological studies with extracts obtained from different parts of this plant have shown cytotoxic activity, bactericidal and anti-tumor. Thus, this study aimed to identify and quantify the phenolic compounds of the hydroalcoholic extract of leaves D. furfuracea (HEDP), methanol (Mt-OH) and ethyl acetate (Ac-OEt) fractions by HPLC, and carry out

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Weis, Simone Nardin. "Efeitos de compostos orgânicos de selênio sobre o desenvolvimento intra-uterino da prole de ratas wistar." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/11081.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Selenium (Se) is an essential trace element for man and is known for its role in regulating growth and development of the fetus and newborn. It is well known that Se deficiency is related to miscarriages and pre-term deliveries. However, it is established that Se compounds, depending of dose, can be highly toxic to several species of animals. The organoselenium compounds, diphenyl diselenide [(PhSe)2] and 3 3- ditrifluoromethyldiphenyl diselenide [(F3CPhSe)2] were the target of this study since they present important pharmacologi

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Okamoto, Débora Noma [UNESP]. "Efeito de substâncias químicas de uso laboratorial sobre Drosophila melanogaster (Diptera - Drosophilidade) do ponto de vista bioquímico e fenotípico." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/87569.

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Made available in DSpace on 2014-06-11T19:22:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-16Bitstream added on 2014-06-13T20:29:22Z : No. of bitstreams: 1 okamoto_dn_me_sjrp.pdf: 676452 bytes, checksum: 7d8aa473e5171e8c8a4187d9499700da (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A presença de resíduos químicos no ambiente afeta todo o ecossistema. Uma das técnicas empregadas para o estudo dos efeitos tóxicos dos resíduos químicos é o biomonitoramento, que utiliza como modelos organismos vivos, entre eles os insetos. Um dos gêneros utiliza

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Azevedo, Mariana Barbieri de. "Avalia??o da atividade das ectonucleotidases em resposta aos efeitos adversos causados pela exposi??o a 2,3,7,8- Tetraclorodibenzeno-p-dioxina (TCDD) utilizando zebrafish (Danio rerio) como modelo de estudo." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/5418.

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Made available in DSpace on 2015-04-14T14:51:13Z (GMT). No. of bitstreams: 1 434409.pdf: 489532 bytes, checksum: 6d9ad85140ac1052e70482873df7cc50 (MD5) Previous issue date: 2011-08-03<br>A 2,3,7,8-tetraclorodibenzeno-p-dioxina (TCDD) ? membro de um grupo de contaminantes ambientais conhecido como hidrocarboneto arom?tico policlorinato e pode ser formada durante o processo de branqueamento com cloro, utilizado por f?brica de celulose e papel e como um subproduto da fabrica??o de determinados produtos qu?micos. Uma vez associado a ligantes como a TCDD, o receptor de hidrocarboneto arila (AHR)

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Jucá, Thiago Lustosa. "Estudo proteômico de sementes em desenvolvimento e maduras de pinhão manso (Jatropha curcas L.)." reponame:Repositório Institucional da UFC, 2010. http://www.repositorio.ufc.br/handle/riufc/18340.

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JUCÁ, Thiago Lustosa. Estudo proteômico de sementes em desenvolvimento e maduras de pinhão manso (Jatropha curcas L.). 2010. 102 f. Dissertação (Mestrado) - Universidade Federal do Ceará, Fortaleza-CE, 2010.<br>Submitted by Eric Santiago (erichhcl@gmail.com) on 2016-07-13T12:51:05Z No. of bitstreams: 1 2010_dis_tljuca.pdf: 10957597 bytes, checksum: 3f8772ad2102c447a821263267f58114 (MD5)<br>Approved for entry into archive by José Jairo Viana de Sousa (jairo@ufc.br) on 2016-07-14T22:57:45Z (GMT) No. of bitstreams: 1 2010_dis_tljuca.pdf: 10957597 bytes, checksum: 3f8772ad2102c447a821263267f58114

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ávila, Daiana Silva de. "Dietil-2-fenil-2-telurofenil vinilfosfonato: um composto orgânico de telúrio com atividade antioxidante in vitro e com baixa toxicidade in Vivo em camundongos." Universidade Federal de Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/11153.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Despite the growing use of organotellurium compounds in chemical and biochemical fields, there is no great concern about their toxicity until now. Diethyl-2-phenyl-2-tellurophenyl vinylphospnonate is a β-organochalcogenyl vinylphosphonate that is a usefull tool for organic synthesis, but no toxicological and pharmacological studies about it are described in the literature. In this study, we investigated, in vitro, the possible antioxidant activity and toxic properties of this compound, and evaluated its putative toxicological effec

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Algarve, Thaís Doeler. "EFEITO TOXICOGENÉTICO DO POLIMORFISMO ALA16VAL DO GENE MnSOD EM LEUCÓCITOS EXPOSTOS IN VITRO AO METIL MERCÚRIO." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11191.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The environmental contamination by methyl mercury (MeHg) is a great health public problem in some world regions like Amazonia. The MeHg toxic effects seem to be influenced by environmental and genetic factors. However, there are few studies evaluating the genetic influence on MeHg toxicity in humans. Therefore, the aim of this present study was to evaluate the genetic influence of Ala16Val superoxide dismutase manganese dependent gene polymorphism (Ala16Val-MnSOD) on cytotoxic effects of in vitro human leucocytes exposed to MeHg. S

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