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Journal articles on the topic 'Bioreactors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Reza, Víctor, Jorge A. Torres-Muñoz, and Jesús Guerrero. "Application of the ADRC Tunned with the Attractive Ellipsoid Approach for Continuous Bioreactors." Memorias del Congreso Nacional de Control Automático 7, no. 1 (2024): 375–80. https://doi.org/10.58571/cnca.amca.2024.064.

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The control of continuous bioreactors is essential for many bioprocesses. However, it is challenging to design and analyze controllers in a closed loop with a bioreactor due to the presence of uncertainties, external disturbances, and highly nonlinear and complex unknown dynamics. In this work, an active disturbance rejection controller is designed and analyzed for continuous bioreactors. For this task, the attractive ellipsoid approach is applied to analyze and tune the proposed controller based on an observer in a closed loop with the bioreactor’s nonlinear dynamic. Finally, the proposed alg

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Feyereisen, Gary W., Ehsan Ghane, Todd W. Schumacher, Brent J. Dalzell, and M. R. Williams. "Can Woodchip Bioreactors Be Used at a Catchment Scale? Nitrate Performance and Sediment Considerations." Journal of the ASABE 66, no. 2 (2023): 367–79. http://dx.doi.org/10.13031/ja.15496.

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Highlights Novel three-bed, cascading-inlet bioreactor treated agricultural drainage from a 249-ha catchment. Nitrate removal rates and load reduction efficiencies were similar to those of traditional single-field bioreactors. Sedimentation problems reduced bed life; a sediment sensing and exclusion system solved them. This scale provides opportunities for centralized management and nutrient reduction verification. Abstract. Denitrifying bioreactors, a structural practice deployed at the field scale to meet water quality goals, have been underutilized and require additional evaluation at the s

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Ritonja, Jozef, Andreja Gorsek, and Darja Pecar. "Control of Milk Fermentation in Batch Bioreactor." Elektronika ir Elektrotechnika 26, no. 1 (2020): 4–9. http://dx.doi.org/10.5755/j01.eie.26.1.23377.

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In this paper, modelling and control of a batch bioreactor is studied. A main disadvantage of batch bioreactors compared to other types of bioreactors is their inability to introduce biological or/and chemical substances during operation. Therefore, possibility of bioreactor’s control by means of changing temperature was proposed, analyzed, and implemented. A new supplementary input/output dynamical mathematical model, which considers influence of heating and cooling on a bioprocess, was developed. On a basis of this model, a control system was designed and a method for tuning of the controlle

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Oktiawan, Wiharyanto, Irawan Wisnu Wardhana, Endro Sutrisno, Domuanri Gorat, and Alfian Rizky Rizaldianto. "Municipal Solid Waste Management Using Bioreactor Landfill in the Treatment of Organic Waste from Jatibarang Landfill, Semarang-Indonesia." E3S Web of Conferences 125 (2019): 07002. http://dx.doi.org/10.1051/e3sconf/201912507002.

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Landfilling is one of the easiest methods to be applied in the management of municipal solid waste (MSW). In its development, bioreactor landfill methods that have various advantages over conventional landfill emerge. This experiment aims to study the use of bioreactor landfills for the management of organic waste in Jatibarang Landfill, Semarang-Indonesia. There are 4 bioreactor landfills operated: 2 anaerobic bioreactors with leachate recirculation and addition of water, and 2 aerobic bioreactors. Different results are shown from these two types of bioreactor, where aerobic bioreactors reach

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Christianson, Laura E., Richard A. Cooke, Christopher H. Hay, et al. "Effectiveness of Denitrifying Bioreactors on Water Pollutant Reduction from Agricultural Areas." Transactions of the ASABE 64, no. 2 (2021): 641–58. http://dx.doi.org/10.13031/trans.14011.

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HighlightsDenitrifying woodchip bioreactors treat nitrate-N in a variety of applications and geographies.This review focuses on subsurface drainage bioreactors and bed-style designs (including in-ditch).Monitoring and reporting recommendations are provided to advance bioreactor science and engineering.Abstract. Denitrifying bioreactors enhance the natural process of denitrification in a practical way to treat nitrate-nitrogen (N) in a variety of N-laden water matrices. The design and construction of bioreactors for treatment of subsurface drainage in the U.S. is guided by USDA-NRCS Conservatio

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Ghosh, Subhrojyoti, Nainika Srivastava, Shreya Jha, and Nandan Kumar Jana. "Spinner Flask Bioreactor in Tissue Engineering." YMER Digital 21, no. 06 (2022): 611–26. http://dx.doi.org/10.37896/ymer21.06/61.

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Spinner Flask Bioreactors are usually made up of glass or plastic vessel which have been widely used in Tissue Engineering from production of articular cartilage to production of osteoblast cells that help in bone regeneration. Cartilage grown in spinner flask bioreactors had more cells and less GAG than the other types of bioreactors in tissue engineering. In recent years, these bioreactors have also been used for the invitro cultivation of human tenocytes and MSCs. In this type of bioreactor, the cell/scaffold constructs are connected to vertical needles striking from pinnacle of the vessel

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7

Wiharyanto, Oktiawan, Sutrisno Endro, and Hadiwidodo Mochtar. "Performance of Semi-Aerobic Solid Waste Bioreactor in relation to Decomposition Process and Biogas Production." E3S Web of Conferences 73 (2018): 07021. http://dx.doi.org/10.1051/e3sconf/20187307021.

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Solid waste which is sent to Jatibarang landfill in Semarang City can reach up to 4000 m3/day. The composition of solid waste consists of 61.95% of organic waste and 38.05% of inorganic waste. The environmental impacts of solid waste can be reduced using bioreactor methods which being able to accelerate the solid waste decomposition. Large amount of solid waste which is sent to Jatibarang landfill certainly has great potential to environment pollution. Therefore, a technology such as landfill bioreactor is needed to speed up the decomposition process of organic solid waste. Landfill bioreactor

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8

Malhotra, Neeraj. "Bioreactors Design, Types, Influencing Factors and Potential Application in Dentistry. A Literature Review." Current Stem Cell Research & Therapy 14, no. 4 (2019): 351–66. http://dx.doi.org/10.2174/1574888x14666190111105504.

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Objectives:A variety of bioreactors and related approaches have been applied to dental tissues as their use has become more essential in the field of regenerative dentistry and dental tissue engineering. The review discusses the various types of bioreactors and their potential application in dentistry.Methods:Review of the literature was conducted using keywords (and MeSH) like Bioreactor, Regenerative Dentistry, Fourth Factor, Stem Cells, etc., from the journals published in English. All the searched abstracts, published in indexed journals were read and reviewed to further refine the list of

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9

Dzianik, František, and Štefan Gužela. "Basic Technological Parameters of the Activation Process for Two Bioreactor Configurations." Strojnícky časopis - Journal of Mechanical Engineering 73, no. 1 (2023): 43–54. http://dx.doi.org/10.2478/scjme-2023-0004.

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Abstract Technological parameters of the activation process in wastewater treatment plant activation systems are analyzed for basic bioreactor configurations, for the chemostat and for the plug flow, both with the recirculation of concentrated activated sludge. The first type of bioreactors represents conventional aerated tanks, but also loop bioreactors. The second type of bioreactors includes, for example, oxidation ditches. The paper presents an evaluation of the basic technological parameters of the activation process for the two mentioned configurations of bioreactor systems with recircul

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Catapano, Gerardo, Juliane K. Unger, Elisabetta M. Zanetti, Gionata Fragomeni, and Jörg C. Gerlach. "Kinetic Analysis of Lidocaine Elimination by Pig Liver Cells Cultured in 3D Multi-Compartment Hollow Fiber Membrane Network Perfusion Bioreactors." Bioengineering 8, no. 8 (2021): 104. http://dx.doi.org/10.3390/bioengineering8080104.

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Liver cells cultured in 3D bioreactors is an interesting option for temporary extracorporeal liver support in the treatment of acute liver failure and for animal models for preclinical drug screening. Bioreactor capacity to eliminate drugs is generally used for assessing cell metabolic competence in different bioreactors or to scale-up bioreactor design and performance for clinical or preclinical applications. However, drug adsorption and physical transport often disguise the intrinsic drug biotransformation kinetics and cell metabolic state. In this study, we characterized the intrinsic kinet

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Nokhbatolfoghahaei, Hanieh, Mahboubeh Bohlouli, Kazem Adavi, et al. "Computational modeling of media flow through perfusion-based bioreactors for bone tissue engineering." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 234, no. 12 (2020): 1397–408. http://dx.doi.org/10.1177/0954411920944039.

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Bioreactor system has been used in bone tissue engineering in order to simulate dynamic nature of bone tissue environments. Perfusion bioreactors have been reported as the most efficient types of shear-loading bioreactor. Also, combination of forces, such as rotation plus perfusion, has been reported to enhance cell growth and osteogenic differentiation. Mathematical modeling using sophisticated infrastructure processes could be helpful and streamline the development of functional grafts by estimating and defining an effective range of bioreactor settings for better augmentation of tissue engi

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Baihaqi, Rifqi Ahmad, Kencana Ayudya Prabahandari, Yogi Hariyono, Novita Indah Pratiwi, Heri Sutanto, and Yoyon Wahyono. "Application of anaerobic and aerobic bioreactors in detergent wastewater treatment: A review." IOP Conference Series: Earth and Environmental Science 1098, no. 1 (2022): 012034. http://dx.doi.org/10.1088/1755-1315/1098/1/012034.

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Abstract The laundry business sector is expanding quickly nowadays. However, the laundry industry is still dealing with the issue of processing detergent wastewater. Anaerobic and aerobic bioreactors may efficiently solve this problem. This narrative review aims to assess the feasibility of using anaerobic and aerobic bioreactors for detergent wastewater treatment. Its advantages and disadvantages and the idea of combining multi-media filtration and UV light in detergent wastewater treatment using an aerobic and aerobic bioreactor. The anaerobic bioreactor can reduce chemical and biological ox

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Grün, Christoph, Brigitte Altmann, and Eric Gottwald. "Advanced 3D Cell Culture Techniques in Micro-Bioreactors, Part I: A Systematic Analysis of the Literature Published between 2000 and 2020." Processes 8, no. 12 (2020): 1656. http://dx.doi.org/10.3390/pr8121656.

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Bioreactors have proven useful for a vast amount of applications. Besides classical large-scale bioreactors and fermenters for prokaryotic and eukaryotic organisms, micro-bioreactors, as specialized bioreactor systems, have become an invaluable tool for mammalian 3D cell cultures. In this systematic review we analyze the literature in the field of eukaryotic 3D cell culture in micro-bioreactors within the last 20 years. For this, we define complexity levels with regard to the cellular 3D microenvironment concerning cell–matrix-contact, cell–cell-contact and the number of different cell types p

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14

Etienne, Hervé, E. Dechamp, D. Barry-Etienne, and Bernóit Bertrand. "Bioreactors in coffee micropropagation." Brazilian Journal of Plant Physiology 18, no. 1 (2006): 45–54. http://dx.doi.org/10.1590/s1677-04202006000100005.

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In coffee, bioreactors are the most promising way for scaling-up micropropagation processes, particularly somatic embryogenesis. The availability of an efficient somatic embryogenesis process would allow the rapid mass production of heterozygous materials such as selected Coffea canephora clones and F1 Arabica hybrid varieties. For the last fifteen years, bioreactors (mechanically or pneumatically agitated bioreactors, temporary immersion bioreactors) have mostly been used on coffee to optimize the mass regeneration of somatic embryos from embryogenic tissues. This review presents the main res

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Liu, Yixuan, Weisi Li, Yanlu Qiao, et al. "Study on the Changes in Immobilized Petroleum–Degrading Bacteria Beads in a Continuous Bioreactor Related to Physicochemical Performance, Degradation Ability, and Microbial Community." International Journal of Environmental Research and Public Health 19, no. 18 (2022): 11348. http://dx.doi.org/10.3390/ijerph191811348.

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Continuous bioreactors for petroleum degradation and the effect factors of these bioreactors have rarely been mentioned in studies. In addition, indigenous bacteria living in seawater could influence the performance of continuous bioreactors with respect to petroleum degradation in practice. In this paper, a bioreactor fitted with immobilized petroleum–degrading bacteria beads was designed for further research. The results indicated that the diesel degradation rate of the bioreactor could remain above 50% over 27 days, while degradation performance decreased with bioremediation time. Intriguin

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Thanapornsin, Thanawat, Likit Sirisantimethakom, Lakkana Laopaiboon, and Pattana Laopaiboon. "Effectiveness of Low-Cost Bioreactors Integrated with a Gas Stripping System for Butanol Fermentation from Sugarcane Molasses by Clostridium beijerinckii." Fermentation 8, no. 5 (2022): 214. http://dx.doi.org/10.3390/fermentation8050214.

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The effectiveness of column bioreactors for butanol fermentation from sugarcane molasses by Clostridium beijerinckii TISTR 1461 was investigated. This fermentation was operated at an initial pH of 6.5 and temperature of 37 °C under anaerobic conditions. A 1-L bubble column bioreactor was used with various gas circulation rates ranging from 0.2 to 1.0 L/min. The highest butanol concentration (PB, 8.72 g/L), productivity (QB, 0.24 g/L∙h) and yield (YB/S, 0.21 g/g) were obtained with a gas circulation of 0.2 L/min. To improve butanol production efficiency, gas-lift column bioreactors with interna

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Deng, Zhi Hua, Ping Ning, Cheng Zhou, Jian Hong Huang, and Kui Yang. "The Biotechnology for Odours-A Review." Advanced Materials Research 403-408 (November 2011): 1432–37. http://dx.doi.org/10.4028/www.scientific.net/amr.403-408.1432.

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This article provides an overview about the microbes selecting, types of bioreactors, the treatment condition, etc. which influence the odors abatement effect. In the recent past, many highly efficiency microorganisms on the actual governance of malodorous gases have been selected and trained. Among different bioreactor configurations, biofilters, biotrickling filters and bioscrubbers are most common ones. The membrane bioreactor and the three phase fluidised bed bioreactor as new bioreactors have broad development prospects. Finally, this review also provides how to insights into future R&amp

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Mancilla-Álvarez, Eucario, Juan Antonio Pérez-Sato, Rosalía Núñez-Pastrana, José L. Spinoso-Castillo, and Jericó J. Bello-Bello. "Comparison of Different Semi-Automated Bioreactors for In Vitro Propagation of Taro (Colocasia esculenta L. Schott)." Plants 10, no. 5 (2021): 1010. http://dx.doi.org/10.3390/plants10051010.

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Taro is important for its nutritional content, medicinal use, and bioethanol production. The aim of the present study was to compare different semi-automated bioreactors (SABs) during in vitro multiplication of C. esculenta. The SABs used were temporary immersion bioreactors (TIBs), SETIS™ bioreactors and ebb-and-flow bioreactors; semi-solid culture medium was used as a control treatment. At 30 d of culture, different developmental variables, determination of chlorophyll, stomatal content, and survival percentage during acclimatization were evaluated. SABs increased the shoot multiplication ra

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Licata, Joseph P., Kyle H. Schwab, Yah-el Har-el, Jonathan A. Gerstenhaber, and Peter I. Lelkes. "Bioreactor Technologies for Enhanced Organoid Culture." International Journal of Molecular Sciences 24, no. 14 (2023): 11427. http://dx.doi.org/10.3390/ijms241411427.

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An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. Recent work has seen organoids gain prominence as a valuable model for studying tissue development, drug discovery, and potential clinical applications. The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. The generation and maturation of high-fidelity organoids entails developing and optimizing environmental conditions to provide the optimal cues for growth and 3D maturation, such as oxygenatio

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Vanags, J., and A. Suleiko. "Oxygen Mass Transfer Coefficient Application in Characterisation of Bioreactors and Fermentation Processes." Latvian Journal of Physics and Technical Sciences 59, no. 5 (2022): 21–32. http://dx.doi.org/10.2478/lpts-2022-0038.

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Abstract This review article covers the topics of evaluation and experimental determination of oxygen mass transfer coefficients (kLa) for their application in characterising bioreactors and fermentations processes. The article provides a comparison of different experimental approaches for determining kLa in bioreactors. Additionally, the influence of bioreactor design and fermentation parameters on kLa is discussed. The aim of the article is to provide useful information regarding the approaches for selecting bioreactors and their working regimes to achieve optimal fermentation results.

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Hartfiel, Lindsey M., Michelle L. Soupir, and Kurt A. Rosentrater. "Techno-Economic Analysis of Constant-Flow Woodchip Bioreactors." Transactions of the ASABE 64, no. 5 (2021): 1545–54. http://dx.doi.org/10.13031/trans.14300.

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HighlightsTechno-economic analysis was performed for multiple scales of bioreactors operated under a variety of conditions.The unit cost decreased as the bioreactor size increased.The unit cost increased in bioreactors with longer HRTs and bypass flow due to reduced treatment capacity.One large bioreactor was more cost-effective than multiple smaller bioreactors.Abstract. Woodchip denitrification bioreactors are a relatively new, edge-of-field technology used to reduce nitrate-nitrogen (NO3-N) from subsurface tile drainage. The removal rate of nitrate is influenced by many factors, including t

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Li, Chengyue, Tahir Maqbool, Hongyu Kang, and Zhenghua Zhang. "In-Situ Sludge Reduction in Membrane-Controlled Anoxic-Oxic-Anoxic Bioreactor: Performance and Mechanism." Membranes 12, no. 7 (2022): 659. http://dx.doi.org/10.3390/membranes12070659.

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Conventional and advanced biological wastewater treatment systems generate excess sludge, which causes socio-economic and environmental issues. This study investigated the performance of membrane-controlled anoxic-oxic-anoxic (AOA) bioreactors for in-situ sludge reduction compared to the conventional anoxic-oxic-oxic membrane bioreactor (MBRcontrol). The membrane units in the AOA bioreactors were operated as anoxic reactors at lower sludge recirculation rates to achieve hydrolysis of extracellular polymeric substances (EPS) and extensive endogenous respiration. Compared to MBRcontrol, the AOA

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Palladino, Fernanda, Paulo Ricardo Franco Marcelino, Andersen Escobar Schlogl, et al. "Bioreactors: Applications and Innovations for a Sustainable and Healthy Future—A Critical Review." Applied Sciences 14, no. 20 (2024): 9346. http://dx.doi.org/10.3390/app14209346.

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Biotechnological processes are essential for developing economies that aim to stand out in future markets. The use of bioreactors is one of the most important unit operations of biotechnological processes, and real-time monitoring of bioreactors is essential to ensure precise bioprocess control. This review presents different types of bioreactors, sensors, and applications in other sectors. Bioreactors, controlled systems for cultivating microorganisms and cells, are essential tools in various fields, from scientific research to industrial production. The use of a variety of sensors is critica

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Kırdök, Onur, Berker Çetintaş, Asena Atay, İrem Kale, Tutku Didem Akyol Altun, and Elif Esin Hameş. "A Modular Chain Bioreactor Design for Fungal Productions." Biomimetics 7, no. 4 (2022): 179. http://dx.doi.org/10.3390/biomimetics7040179.

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Plastic bag bioreactors are single-use bioreactors, frequently used in solid culture fermentation. This study developed plastic bag bioreactors with more effective aeration conditions and particular connection elements that yield sensors, environmental control, and modular connectivity. This bioreactor system integrates the bags in a chain that circulates air and moisture through filtered connections. Within the present scope, this study also aimed to reveal that cultures in different plastic bags can be produced without affecting each other. In this direction, biomass production in the modula

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Conroy, Kristen M., Feng Chen, Olli H. Tuovinen, and Karen M. Mancl. "Effect of Sodium Chloride Concentration on Removal of Chemical Oxygen Demand and Ammonia from Turkey Processing Wastewater in Sand Bioreactors." Applied Engineering in Agriculture 36, no. 1 (2020): 33–37. http://dx.doi.org/10.13031/aea.13632.

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HighlightsSand bioreactors can effectively treat organic matter at salt levels at least up to 13 g L-1 NaCl.Acclimation of the systems for ammonia removal can take &gt;4 weeks.Clogging and reduction in treatment efficacy can be alleviated through resting of sand bioreactors. Abstract. The treatment of high salt (&gt;1%) wastewater is an issue in several food industries, including meat curing, vegetable pickling, and fish processing. Novel solutions involving biological treatment of saline wastewaters are increasingly important as companies strive to minimize waste production. Sand bior

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Burton, Stephanie G. "Development of bioreactors for application of biocatalysts in biotransformations and bioremediation." Pure and Applied Chemistry 73, no. 1 (2001): 77–83. http://dx.doi.org/10.1351/pac200173010077.

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Biotransformation systems, whether used for environmentally benign biocatalysis of synthetic reactions, or bioremediation of pollutants, require suitable biocatalysts and suitable bioreactor systems with particular characteristics. Our research focuses on the bioconversion of organic compounds, many of which are industrial residues, such as phenols, poly-aromatic hydrocarbons, heterocyclic compounds, and polychlorinated biphenyls. The purpose of such biotransformations can be twofold: firstly, to remove them from effluents and convert them to less toxic forms, and secondly, to convert them int

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Bernemann, Vincent, Jürgen Fitschen, Marco Leupold, et al. "Characterization Data for the Establishment of Scale-Up and Process Transfer Strategies between Stainless Steel and Single-Use Bioreactors." Fluids 9, no. 5 (2024): 115. http://dx.doi.org/10.3390/fluids9050115.

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The reliable transfer of bioprocesses from single-use bioreactors (SUBs) of different scales to conventional stainless steel stirred-tank bioreactors is of steadily growing interest. In this publication, a scale-up study for SUBs with volumes of 200 L and 2000 L and the transfer to an industrial-scale conventional stainless steel stirred-tank bioreactor with a volume of 15,000 L is presented. The scale-up and transfer are based on a comparison of mixing times and the modeling of volumetric mass transfer coefficients kLa, measured in all three reactors in aqueous PBS/Kolliphor solution. The mas

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Sirirak, Khanoksinee, Sorawit Powtongsook, Sudarat Suanjit, and Somtawin Jaritkhuan. "Effectiveness of various bioreactors for thraustochytrid culture and production (Aurantiochytruim limacinum BUCHAXM 122)." PeerJ 9 (May 27, 2021): e11405. http://dx.doi.org/10.7717/peerj.11405.

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This study aimed to develop bioreactors for cultivation of thraustochytrid, Aurantiochytrium limacinum BUCHAXM 122, that are low in cost and simple to operate. Obtaining maximum biomass and fatty acid production was a prerequisite. Three bioreactor designs were used: stirred tank bioreactor (STB), bubble bioreactor (BB) and internal loop airlift bioreactor (ILAB). The bioreactors were evaluated for their influence on oxygen mass transfer coefficient (kLa), using various spargers, mixing speed, and aeration rates. Biomass and DHA production from STB, BB, ILAB were then compared with an incubato

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Titova, Maria, Elena Popova, and Alexander Nosov. "Bioreactor Systems for Plant Cell Cultivation at the Institute of Plant Physiology of the Russian Academy of Sciences: 50 Years of Technology Evolution from Laboratory to Industrial Implications." Plants 13, no. 3 (2024): 430. http://dx.doi.org/10.3390/plants13030430.

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The cultivation of plant cells in large-scale bioreactor systems has long been considered a promising alternative for the overexploitation of wild plants as a source of bioactive phytochemicals. This idea, however, faced multiple constraints upon realization, resulting in very few examples of technologically feasible and economically effective biotechnological companies. The bioreactor cultivation of plant cells is challenging. Even well-growing and highly biosynthetically potent cell lines require a thorough optimization of cultivation parameters when upscaling the cultivation process from la

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Kareem, Zana Jamal, Ling Su, Anna Rathgeb, et al. "Small-Scale Bioreactor for Sterile Hydroponics and Hairy Roots: Metabolic Diversity and Salicylic Acid Exudation by Hairy Roots of Hyoscyamus niger." Applied Sciences 9, no. 15 (2019): 3044. http://dx.doi.org/10.3390/app9153044.

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The volume and complexity of commercial bioreactors for sterile hydroponics and hairy roots are too large for comparative analysis of many cultures. Here a small-scale bioreactor fabricated from standard glass materials and suitable for both airlift and bubble aeration mode is described. The performance of the bioreactor was tested by growing oilseed rape (Brassica napus L.) and rose plants (Rosa canina L.) in sterile hydroponics and by cultivating hairy roots of henbane (Hyoscyamus niger L.) and sesame (Hyoscyamus niger L.). Plants grown in hydroponics for up to six weeks did not show chloros

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Kordas, Marian, Maciej Konopacki, Bartłomiej Grygorcewicz, et al. "Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems." Processes 8, no. 10 (2020): 1311. http://dx.doi.org/10.3390/pr8101311.

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Biotechnological processes involving the presence of microorganisms are realized by using various types of stirred tanks or laboratory-scale dual-impeller commercial bioreactor. Hydrodynamics and mass transfer rate are crucial parameters describing the functionality and efficiency of bioreactors. Both parameters strictly depend on mixing applied during bioprocesses conducted in bioreactors. Establishing optimum hydrodynamics conditions for the realized process with microorganisms maximizes the yield of desired products. Therefore, our main objective was to analyze and define the main operation

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van Dijk, L., and G. C. G. Roncken. "Membrane bioreactors for wastewater treatment: the state of the art and new developments." Water Science and Technology 35, no. 10 (1997): 35–41. http://dx.doi.org/10.2166/wst.1997.0353.

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The combination of membrane separation technology and bioreactors has lead to a new focus on wastewater treatment. The application of membranes has led to very compact wastewater treatment systems with an excellent effluent quality. For concentrated wastewaters, like industrial streams and landfill leachate the membrane bioreactor has been applied at full scale successfully. The relatively high energy requirements have hindered the wide spread application of membrane bioreactors. Using new membrane techniques, like transfer flow modules, creates the possibilities of a more widespread applicati

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Fatehi Pouladi, S., B. C. Anderson, B. Wootton, and L. Rozema. "Evaluation of passive reduction of nitrate from greenhouse effluent by planted bioreactors." Water Supply 17, no. 6 (2017): 1764–73. http://dx.doi.org/10.2166/ws.2017.080.

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Abstract A number of pilot-scale gravel and wood-chip hybrid bioreactors planted with select species, together with unplanted units, were evaluated for their nutrient removal capabilities from the typical greenhouse effluent with high levels of nitrate and salts. Two levels of nutrient solution (high and low loading: HL/LL) were prepared to simulate the typical characteristics of the greenhouse effluent. The wood-chip bioreactor with Typha angustifolia exhibited the highest consistent nutrient treatment with an average nitrate reduction in the LL phase of 88.4% (28.2 g N m−3 media day−1) and p

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Kushkevych, Ivan, Monika Vítězová, Tomáš Vítěz, and Milan Bartoš. "Production of biogas: relationship between methanogenic and sulfate-reducing microorganisms." Open Life Sciences 12, no. 1 (2017): 82–91. http://dx.doi.org/10.1515/biol-2017-0009.

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AbstractThe production of high-quality methane depends on many factors, including temperature, pH, substrate, composition and relationship of the microorganisms. The qualitative and quantitative composition of methanogenic and sulfate-reducing microorganisms and their relationship in the experimental bioreactors has never been studied. The aim of this research was to characterize, for the first time, the diversity of the methanogenic microorganisms and sulfate-reducing bacteria, and study their relationship and biogas production in experimental bioreactors. Amplification of 16S rRNA gene fragm

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Zaburko, J., G. Łagód, M. K. Widomski, J. Szulżyk-Cieplak, B. Szeląg, and R. Babko. "Modeling and optimizations of mixing and aeration processes in bioreactors with activated sludge." Journal of Physics: Conference Series 2130, no. 1 (2021): 012027. http://dx.doi.org/10.1088/1742-6596/2130/1/012027.

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Abstract Mixing aimed at homogenization of the volume of bioreactors with the activated sludge is of great importance for the proper course of the wastewater treatment process. It affects both the efficiency of pollutants removal and the properties of the activated sludge related to its sedimentation. The mixing process in bioreactors can be carried out in different ways. In batch bioreactors in the aeration phase or flow bioreactors in aerobic chambers, mixing is carried out through aeration systems. These systems should aerate the activated sludge flocs for efficient biological treating of w

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Shareefdeen, Zarook, Ali Elkamel, and Zaeem Bin Babar. "Recent Developments on the Performance of Algal Bioreactors for CO2 Removal: Focusing on the Light Intensity and Photoperiods." BioTech 12, no. 1 (2023): 10. http://dx.doi.org/10.3390/biotech12010010.

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This work presents recent developments of algal bioreactors used for CO2 removal and the factors affecting the reactor performance. The main focus of the study is on light intensity and photoperiods. The role of algae in CO2 removal, types of algal species used in bioreactors and conventional types of bioreactors including tubular bioreactor, vertical airlift reactor, bubble column reactor, flat panel or plate reactor, stirred tank reactor and specific type bioreactors such as hollow fibre membrane and disk photobioreactors etc. are discussed in details with respect to utilization of light. Th

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Mishra, Maneesh, Shailendra Rajan, and T. Damodaran. "New paradigm shifts in micropropagation of fruit crops through bioreactors - a review." Indian Journal of Horticulture 81, no. 01 (2024): 1–10. http://dx.doi.org/10.58993/ijh/2024.81.1.1.

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within relatively shorter periods, as well as significant reductions in hyperhydricity in plants as a result of efficient gas exchange, oxygen supplementation and automation, bioreactors, specifically temporary immersion systems (TIS), are being utilized for mass multiplication of forestry and horticultural crops. In tissue culture of banana, date palm, strawberrys, papaya, citrus, grape, pineapple, apple, pear, plum, chestnut, pistachio nut, apricot, sweet cherry, and almond, a variety of TIS bioreactors were used, including RITA, Plantform, SETIS and twin glass airlifts. TIS Bioreactors need

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Christianson, Laura Elizabeth, Reid Christianson, Carolina Díaz-García, et al. "Denitrifying Bioreactor In Situ Woodchip Bulk Density." Journal of the ASABE 66, no. 3 (2023): 723–34. http://dx.doi.org/10.13031/ja.15364.

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Highlights The bulk density of woodchips in denitrifying bioreactors in the field is unknown. In situ bulk density estimation methods were developed for use during construction or excavation. Dry bulk densities of aged woodchips at bioreactor bottoms were lower than previous literature values. Moisture and particle size and density explained some, but not all, of the variation in in situ bulk densities. Abstract. Woodchip bulk density in a denitrifying bioreactor governs system hydraulics, but this prime physical attribute has never been estimated in situ. The objectives were twofold: (1) to e

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Pluer, William T., M. Todd Walter, and Scott Steinschneider. "Understanding Complex Flow Pathways within Lab-Scale Denitrifying Bioreactors with a Conservative Tracer." Transactions of the ASABE 63, no. 2 (2020): 417–27. http://dx.doi.org/10.13031/trans.13629.

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HighlightsStorm size and media age did not significantly impact removal rate based on simulated storm events in lab bioreactors.Post-hoc cluster analysis of bromide tracer time series identified distributed and preferential flow patterns.Distributed flow cluster had significantly higher removal rate and removal efficiency than preferential cluster.Abstract. Denitrifying bioreactors are designed to reduce excess nitrate (NO3-) pollution from agricultural fields. During storm-induced flow events, flow rate and hydraulic retention time (HRT) can fluctuate widely, which may disturb denitrification

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Lim, B. R., H. Y. Hu, N. Goto, and K. Fujie. "PVA-coated activated carbon for aerobic biological treatment of concentrated refractory organic wastewater." Water Science and Technology 42, no. 3-4 (2000): 205–10. http://dx.doi.org/10.2166/wst.2000.0381.

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The treatment characteristics of concentrated p-phenol sulfonic acid (PSA) wastewater in a submerged bioreactor and a solid phase bioreactor packed with ACP particles (polyvinyl alcohol particles coated with powered activated carbon) were compared experimentally. The changes in biomass and microbial community with the degradation of PSA at both bioreactors were also evaluated using microbial quinones as an index. Greater than 95% of influent PSA was mineralized at the solid phase bioreactor under the volumetric loading of PSA ranging from 0.3 to 1.8 kg-C·m-3·d-1 at the steady state, but less t

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Schirmer, Cedric, Rüdiger W. Maschke, Ralf Pörtner, and Dieter Eibl. "An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes." Applied Microbiology and Biotechnology 105, no. 6 (2021): 2225–42. http://dx.doi.org/10.1007/s00253-021-11180-7.

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AbstractNo matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal use

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Biliaiev, M. M., P. B. Mashykhina, L. H. Tatarko, A. O. Chirkov, and M. V. Chyrva. "EXPRESS CALCULATION OF OXYGEN REGIME IN WASTEWATER FACILITIES." Ukrainian Journal of Civil Engineering and Architecture, no. 6 (018) (February 24, 2024): 29–34. http://dx.doi.org/10.30838/j.bpsacea.2312.261223.29.1004.

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Problem statement. The efficiency of biological water purification depends significantly on the concentration of dissolved oxygen in the volume of the bioreactor. But during the operation of bioreactors, the oxygen regime changes, so it is important to predict the oxygen concentration for different modes of operation of treatment plants. Simplified mathematical models are used to calculate the oxygen regime, but these models are designed for typical bioreactors. An important task is the development of effective multivariate numerical models for evaluating the oxygen regime in reactors of diffe

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Bondarenko, N. A., E. V. Guseva, and R. R. Safarov. "Application of computational fluid dynamics for simulation of stirred bioreactors in Ansys Fluent." Proceedings of the Voronezh State University of Engineering Technologies 85, no. 2 (2023): 123–29. http://dx.doi.org/10.20914/2310-1202-2023-2-123-129.

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Stirred bioreactors are widely used in the pharmaceutical industry to produce various active substances for the treatment of cancer, heart and vascular diseases, viral and bacterial infections. Despite the widespread use of bioreactors with a stirrer, the optimization of mixing conditions remains an urgent task. In bioreactors of this type, continuous mixing of cells in a medium with a high rotation speed should be carried out. The manuscript considers an example of the use of computational fluid dynamics to study and model the process of cultivation Escherichia coli bacterial cells in a batch

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Lakov, V., E. Chorukova, and I. Simeonov. "Mathematical Modelling and Extremum Seeking Control of Cascade of Two Bioreactors for Production of Hydrogen and Methane." Information Technologies and Control 15, no. 2 (2017): 6–13. http://dx.doi.org/10.1515/itc-2017-0022.

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Abstract A mathematical model of a cascade of two continuously stirred anaerobic bioreactors is presented in this paper and the extremum seeking control is applied on it. The dilution rate of the first bioreactor is chosen as control action and the joint biogas flow rate both bioreactors is the measured output to be maximized. The concentration of inlet organics is accepted as the disturbance. The correction of the working volume of the second bioreactor is studied as the inner loop of the cascade control system. The outer control loop is represented by the extremum seeking controller, which f

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Kazimierczak, Paulina, and Agata Przekora. "Bioengineered Living Bone Grafts—A Concise Review on Bioreactors and Production Techniques In Vitro." International Journal of Molecular Sciences 23, no. 3 (2022): 1765. http://dx.doi.org/10.3390/ijms23031765.

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It has been observed that bone fractures carry a risk of high mortality and morbidity. The deployment of a proper bone healing method is essential to achieve the desired success. Over the years, bone tissue engineering (BTE) has appeared to be a very promising approach aimed at restoring bone defects. The main role of the BTE is to apply new, efficient, and functional bone regeneration therapy via a combination of bone scaffolds with cells and/or healing promotive factors (e.g., growth factors and bioactive agents). The modern approach involves also the production of living bone grafts in vitr

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Granata, Tim, Bernd Rattenbacher, Florian Kehl, and Marcel Egli. "Microbial Factories and Exploiting Synergies of Bioreactor Technologies to Produce Bioproducts." Fermentation 10, no. 3 (2024): 135. http://dx.doi.org/10.3390/fermentation10030135.

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Microbial factories, including microalgae biofactories, have the enormous potential to produce biochemicals for manufacturing diverse bioproducts. A strategic approach to biofactories is maintaining cultures in bioreactors with sufficient resource inputs to optimize biochemical precursors for manufacturing bioproducts. Exploiting synergies that use the waste output from a bioreactor containing one microbial culture as a resource input to another bioreactor with a different microbe can lead to overall efficiencies in biofactories. In this paper, two synergies are evaluated. The first is between

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Chisti, Yusuf. "Pneumatically Agitated Bioreactors in Industrial and Environmental Bioprocessing: Hydrodynamics, Hydraulics, and Transport Phenomena." Applied Mechanics Reviews 51, no. 1 (1998): 33–112. http://dx.doi.org/10.1115/1.3098989.

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Major aspects of design and operation of pneumatically agitated bioreactors are reviewed. The focus is on considerations that are relevant to industrial practice. Airlift bioreactors are emphasized. The treatment covers hydraulics, hydrodynamics, gas-liquid and solid-liquid mass transfer, heat transfer, mixing, and suspension. Newtonian and non-Newtonian systems are discussed. Applications in microbial fermentations, animal and plant cell culture, biotransformations with immobilized enzymes, and treatment of wastewater are outlined. Comparisons with more conventional bioreactor technologies ar

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Pathak, Nirenkumar, Van Huy Tran, Andrea Merenda, M. A. H. Johir, Sherub Phuntsho, and Hokyong Shon. "Removal of Organic Micro-Pollutants by Conventional Membrane Bioreactors and High-Retention Membrane Bioreactors." Applied Sciences 10, no. 8 (2020): 2969. http://dx.doi.org/10.3390/app10082969.

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The ubiquitous presence of organic micropollutants (OMPs) in the environment as a result of continuous discharge from wastewater treatment plants (WWTPs) into water matrices—even at trace concentrations (ng/L)—is of great concern, both in the public and environmental health domains. This fact essentially warrants developing and implementing energy-efficient, economical, sustainable and easy to handle technologies to meet stringent legislative requirements. Membrane-based processes—both stand-alone or integration of membrane processes—are an attractive option for the removal of OMPs because of

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Maxwell, Bryan, Laura Christianson, Richard A. C. Cooke, et al. "Nitrate Removal and Woodchip Properties across a Paired Denitrifying Bioreactor Treating Centralized Agricultural Ditch Flows." Water 14, no. 1 (2021): 56. http://dx.doi.org/10.3390/w14010056.

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Treatment of nitrate loads by denitrifying bioreactors in centralized drainage ditches that receive subsurface tile drainage may offer a more effective alternative to end-of-pipe bioreactors. A paired denitrifying bioreactor design, consisting of an in-ditch bioreactor (18.3 × 2.1 × 0.2 m) treating ditch base flow and a diversion bioreactor (4.6 × 9.1 × 0.9 m) designed to treat high-flow events, was designed and constructed in an agricultural watershed (3.2 km2 drainage area) in Illinois, USA. Flow and water chemistry were monitored for three years and the woodchip and bioreactor-associated so

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Stoyancheva, Galina, Lyudmila Kabaivanova, Venelin Hubenov, and Elena Chorukova. "Metagenomic Analysis of Bacterial, Archaeal and Fungal Diversity in Two-Stage Anaerobic Biodegradation for Production of Hydrogen and Methane from Corn Steep Liquor." Microorganisms 11, no. 5 (2023): 1263. http://dx.doi.org/10.3390/microorganisms11051263.

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The main purpose of this study was to identify the microbial communities (bacterial, archaeal and fungal) in a two-stage system of anaerobic bioreactors for the production of hydrogen and methane from the waste substrate—corn steep liquor. Wastes from the food industry are valuable resources with potential in biotechnological production because of their high organic matter contents. In addition, the production of hydrogen and methane, volatile fatty acids, reducing sugars and cellulose content was monitored. Two-stage anaerobic biodegradation processes were performed by microbial populations i

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