Relevant bibliographies by topics / Biotransformation enzymes

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Biotransformation enzymes'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Biotransformation enzymes"

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Li, Peng, Ruixue Su, Ruya Yin, et al. "Detoxification of Mycotoxins through Biotransformation." Toxins 12, no. 2 (2020): 121. http://dx.doi.org/10.3390/toxins12020121.

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Mycotoxins are toxic fungal secondary metabolites that pose a major threat to the safety of food and feed. Mycotoxins are usually converted into less toxic or non-toxic metabolites through biotransformation that are often made by living organisms as well as the isolated enzymes. The conversions mainly include hydroxylation, oxidation, hydrogenation, de-epoxidation, methylation, glycosylation and glucuronidation, esterification, hydrolysis, sulfation, demethylation and deamination. Biotransformations of some notorious mycotoxins such as alfatoxins, alternariol, citrinin, fomannoxin, ochratoxins
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Taylor, I. N., R. C. Brown, M. Bycroft, et al. "Application of thermophilic enzymes in commercial biotransformation processes." Biochemical Society Transactions 32, no. 2 (2004): 290–92. http://dx.doi.org/10.1042/bst0320290.

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Biocatalysis is a useful tool in the provision of chiral technology and extremophilic enzymes are just one component in that toolbox. Their role is not always attributable to their extremophilic properties; as with any biocatalyst certain other criteria should be satisfied. Those requirements for a useful biocatalyst will be discussed including issues of selectivity, volume efficiency, security of supply, technology integration, intellectual property and regulatory compliance. Here we discuss the discovery and commercialization of an l-aminoacylase from Thermococcus litoralis, the product of a
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Serra, Stefano. "Enzyme-Mediated Synthesis of Sesquiterpenes." Natural Product Communications 10, no. 1 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000136.

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This review article focuses mainly on the scientific developments concerning the enzyme-mediated synthesis of sesquiterpenes which have been reported in the academic and patent literature during the last twenty years. Nevertheless, this is not a comprehensive description of every single biotransformation involving sesquiterpenes. Only synthetic approaches that have represented a new and innovative perspective from a scientific standpoint are reported. More specifically, the review describes in depth how the use of metabolic engineering of the microbial biotransformations and of the isolated en
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Sakamoto, Takeshi, John M. Joern, Akira Arisawa, and Frances H. Arnold. "Laboratory Evolution of Toluene Dioxygenase To Accept 4-Picoline as a Substrate." Applied and Environmental Microbiology 67, no. 9 (2001): 3882–87. http://dx.doi.org/10.1128/aem.67.9.3882-3887.2001.

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ABSTRACT We are using directed evolution to extend the range of dioxygenase-catalyzed biotransformations to include substrates that are either poorly accepted or not accepted at all by the naturally occurring enzymes. Here we report on the oxidation of a heterocyclic substrate, 4-picoline, by toluene dioxygenase (TDO) and improvement of the enzyme's activity by laboratory evolution. The biotransformation of 4-picoline proceeds at only ∼4.5% of the rate of the natural reaction on toluene. Random mutagenesis, saturation mutagenesis, and screening directly for product formation using a modified G
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Noten, J. B. G. M., W. M. A. Verhoeven, S. Tuinier, and D. Touw. "Therapeutic drug monitoring." Acta Neuropsychiatrica 11, no. 1 (1999): 15–16. http://dx.doi.org/10.1017/s0924270800036309.

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SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2. Knowledge about the involvement of these enzymes and biotransformation processes is mandatory because of the individual variability in their metabolic capacity. Regular measurement of plasmaconcentrations of (psycho)pharmacological compounds is therefore essential. In addition, the potential value of pheno- and/or ge
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Kazenwadel, F., H. Wagner, B. E. Rapp, and M. Franzreb. "Optimization of enzyme immobilization on magnetic microparticles using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as a crosslinking agent." Analytical Methods 7, no. 24 (2015): 10291–98. http://dx.doi.org/10.1039/c5ay02670a.

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Hickey, A. M., L. Marle, T. McCreedy, P. Watts, G. M. Greenway, and J. A. Littlechild. "Immobilization of thermophilic enzymes in miniaturized flow reactors." Biochemical Society Transactions 35, no. 6 (2007): 1621–23. http://dx.doi.org/10.1042/bst0351621.

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The exploitation of enzymes for biotransformation reactions for the production of new and safer drug intermediates has been the focus of much research. While a number of enzymes are commercially available, their use in an industrial setting is often limited to reactions that are cost-effective and they are rarely investigated further. However, the development of miniaturized flow reactor technology has meant that the cost of such research, once considered cost- and time-inefficient, would be much less prohibitive. The use of miniaturized flow reactors for enzyme screening offers a number of ad
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Bhosale, Sanjyot, Ganesh Saratale, and Sanjay Govindwar. "Biotransformation enzymes inCunninghamella blakesleeana (NCIM-687)." Journal of Basic Microbiology 46, no. 6 (2006): 444–48. http://dx.doi.org/10.1002/jobm.200510117.

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Zhang, Donglu, Thomas H. Pillow, Dian Su, et al. "Biotransformation of ADCs. Pathways and enzymes." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S13. http://dx.doi.org/10.1016/j.dmpk.2018.09.065.

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Rekka, Eleni A., Panos N. Kourounakis, and Maria Pantelidou. "Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design." Current Topics in Medicinal Chemistry 19, no. 4 (2019): 276–91. http://dx.doi.org/10.2174/1568026619666190129122727.

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Background: The biotransformation of xenobiotics is a homeostatic defensive response of the body against bioactive invaders. Xenobiotic metabolizing enzymes, important for the metabolism, elimination and detoxification of exogenous agents, are found in most tissues and organs and are distinguished into phase I and phase II enzymes, as well as phase III transporters. The cytochrome P450 superfamily of enzymes plays a major role in the biotransformation of most xenobiotics as well as in the metabolism of important endogenous substrates such as steroids and fatty acids. The activity and the poten
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Dissertations / Theses on the topic "Biotransformation enzymes"

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Martin, Jacqueline Delyth. "Characterisation of hydrolase enzymes important in biotransformation reactions." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246395.

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Gradley, Michelle Lorraine. "Biotransformation of nitriles by Rhodococcus rhodocrous NCIMB 11216." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240163.

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Sun, Fangfang. "Development of Building Blocks - Thermostable Enzymes for Synthetic Pathway Biotransformation (SyPaB)." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/77009.

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Hydrogen production from abundant renewable biomass would decrease reliance on crude oils, achieve nearly zero net greenhouse gas emissions, create more jobs, and enhance national energy security. Cell-free synthetic pathway biotransformation (SyPaB) is the implementation of complicated chemical reaction by the in vitro assembly of numerous enzymes and coenzymes that microbes cannot do. One of the largest challenges is the high cost and instability of enzymes and cofactors. To overcome this obstacle, strong motivations have driven intensive efforts in discovering, engineering, and producing th
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Steiner, Claudia. "Les enzymes chimiosensorielles : de nouvelles cibles pour perturber l'olfaction des insectes nuisibles ?" Thesis, Paris, Institut agronomique, vétérinaire et forestier de France, 2017. http://www.theses.fr/2017IAVF0015.

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De nombreux insectes s’avèrent être des ravageurs de culture, pouvant de surcroît transmettre des pathogènes aux plantes et ainsi causer des dégâts d’importance économique notables. Leur contrôle repose essentiellement sur l’utilisation d’insecticides, mais cela pose problème en termes de pollution de l’environnement, d’effets non désirés sur les espèces non-cibles, d’apparition de populations d’insectes résistants aux insecticides, sans parler de leur toxicité pour l’homme. L’olfaction joue un rôle clef dans le développement de nombreux comportements chez les insectes, comme la recherche de l
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Guerre, Philippe. "Incidence d'une aflatoxicose sur les enzymes de biotransformation hepatique chez le lapin." Paris 7, 1996. http://www.theses.fr/1996PA077213.

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L'objectif des travaux presentes est de preciser les actions de l'aflatoxine b1 (afb1) sur les enzymes de biotransformation hepatique, et tout particulierement le systeme cytochrome p450 dependant. Ces etudes ont ete conduites in vivo chez le lapin, et ex vivo sur cultures primaires d'hepatocytes de cette espece. Des doses croissantes d'afb1 ont ete utilisees afin de reveler d'eventuelles relations dose-effet. La toxicite generale de la mycotoxine a ete exploree pour chaque dose afin de discerner ses effets specifiques des consequences de sa toxicite generale. In vivo, aux fortes doses, differ
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Brocklebank, Simon Pearson. "Rational immobilisation of enzymes : immobilisation of transketolase for carbon-carbon bond synthesis." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322288.

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Huang, Wen-hsin. "Application of comparative molecular field analysis for predicting microbial sulfoxidation /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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Deo, Anand K. "Hepatic microsomal bile acid biotransformation : identification of metabolites and cytochrome p450 enzymes involved." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/15222.

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Bile acids are end-products of cholesterol metabolism and essential for absorption of dietary lipids in the body. Impaired bile flow leads to hepatic bile acid accumulation and liver damage. Hepatic microsomal oxidation offers a potential mechanism for efficient elimination of bile acids. The present study investigated the cytochrome P450 (P450)-mediated hepatic microsomal biotransformation profiles of lithocholic acid, cholic acid and chenodeoxycholic acid using a liquid chromatography-mass spectrometry (LCIMS) based assay. Incubation of lithocholic acid with rat hepatic microsomes resulted i
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Akrawi, May Ghanim. "Long-term preservation and induction of biotransformation enzymes in co-cultured rat hepatocytes." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283279.

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Ferre, Elisée. "Biotransformation de composés alléniques, reconnaissance de leur chiralité axiale par des enzymes microbiennes." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37597586p.

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Books on the topic "Biotransformation enzymes"

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Faber, K. Biotransformations in organic chemistry. Springer-Verlag, 1992.

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Rehm, Hans-Jürgen, P. Stadler, A. Pühler, D. R. Kelly, and Gerald Reed. Biotechnology: Biotransformations II. 2nd ed. Wiley-VCH, 2000.

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Faber, K. Biotransformations in organic chemistry: A textbook. 3rd ed. Springer Verlag, 1997.

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Faber, K. Biotransformations in organic chemistry: A textbook. 2nd ed. Springer-Verlag, 1995.

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Practical methods for biocatalysis and biotransformations. J. Wiley, 2010.

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Kumar, Kruthiventi Anil, and Gaikar Vilas Gajanan, eds. Biotransformations and bioprocesses. Marcel Dekker, 2004.

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Sutton, Peter, and John Whittall. Practical methods for biocatalysis and biotransformations. 2nd ed. John Wiley & Sons Inc., 2012.

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Barredo, José Luis, ed. Microbial Enzymes and Biotransformations. Humana Press, 2005. http://dx.doi.org/10.1385/1592598463.

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Naylor, Neil J. Biotransformations involving hydrolytic enzymes. typescript, 1997.

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Garcia-Junceda, Eduardo. Multi-step enzyme catalysis: Biotransformations and chemoenzymatic synthesis. Wiley-VCH, 2008.

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Book chapters on the topic "Biotransformation enzymes"

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Sudhakaran, Sudheesh, T. M. Archana, and C. N. Aguilar. "Biotransformation Enzymes." In Bioresources and Bioprocess in Biotechnology. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4284-3_5.

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Das, Deeplina, and Arun Goyal. "Pharmaceutical Enzymes." In Biotransformation of Waste Biomass into High Value Biochemicals. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8005-1_15.

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Eaton, David L. "Aflatoxin Biotransformation and Toxicology." In Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4855-3_14.

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Krishna, S. Hari, N. D. Srinivas, K. S. M. S. Raghavarao, and N. G. Karanth. "Reverse Micellar Extraction for Downstream Processing of Proteins/Enzymes." In History and Trends in Bioprocessing and Biotransformation. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-44604-4_5.

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Klinger, Wolfgang. "Developmental Regulation of Biotransformation of Drugs and other Xenobiotics." In Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79528-2_13.

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Kaneko, Hideo. "Biotransformation and Enzymes Responsible for Metabolism of Pyrethroids in Mammals." In ACS Symposium Series. American Chemical Society, 2012. http://dx.doi.org/10.1021/bk-2012-1099.ch004.

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Gillam, Elizabeth M. J., and Dominic J. B. Hunter. "Chemical Defense and Exploitation. Biotransformation of Xenobiotics by Cytochrome P450 Enzymes." In The Ubiquitous Roles of Cytochrome P450 Proteins. John Wiley & Sons, Ltd, 2007. http://dx.doi.org/10.1002/9780470028155.ch15.

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Steiner, Claudia, Thomas Chertemps, and Martine Maïbèche. "Diversity of Biotransformation Enzymes in Insect Antennae: Possible Roles in Odorant Inactivation and Xenobiotic Processing." In Olfactory Concepts of Insect Control - Alternative to insecticides. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05165-5_5.

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Hoh, Christoph, and Murillo Villela Filho. "The Enzyme Classification." In Industrial Biotransformations. Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/9783527608188.ch2.

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Pool-Zobel, Beatrice L. "Diet and Biotransformation of Carcinogenic Compounds in the Gut by Enzymes of Microflora and of Intestinal Cells." In Colonic Microbiota, Nutrition and Health. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-017-1079-4_15.

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Conference papers on the topic "Biotransformation enzymes"

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Li, Wen Lan, Yang Yang, Yubin Ji, and Zheng Ting Hu. "The Study on Biotransformation of Paeonol and Interrelation with Cytochrome P450 Enzymes." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163674.

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Qi, Xianghui, Fei Wang, Wenying Deng, et al. "Advances on the key enzymes and engineering bacteria of biotransformation of glycerol into 1,3-propanediol." In International conference on Human Health and Medical Engineering. WIT Press, 2014. http://dx.doi.org/10.2495/hhme130421.

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Lampe, Johanna W. "Abstract CN06-04: Vegetable constituents and biotransformation enzymes: The effect of genetic variation on response." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Nov 7-10, 2010; Philadelphia, PA. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1940-6207.prev-10-cn06-04.

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Harris, Deacqunita L., Mary K. Washington, Darryl B. Hood, Lyman J. Roberts, and Aramandla Ramesh. "Abstract 3448: Synergistic effect of benzo(a)pyrene (BaP) and dietary fat on biotransformation enzymes, DNA adducts and colon tumors in ApcMinmice." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3448.

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Ignatova, Tatiana, Tatiana Rodina, Natalia Strokova, and Irina Igonina. "BIOTRANSFORMATION OF SQUID WASTE PROCESSING OF BERRYTERTHIS MAGISTER BY ENZYME OF MICROBIOLOGICAL ORIGIN." In 20th International Multidisciplinary Scientific GeoConference Proceedings SGEM 2020. STEF92 Technology, 2020. http://dx.doi.org/10.5593/sgem2020/6.1/s25.024.

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Lanjekar, K., and N. Gharat. "In vitro enzyme catalytic biotransformation of Carbon dioxide into useful chemicals - A short review." In 2011 International Conference on Green Technology and Environmental Conservation (GTEC 2011). IEEE, 2011. http://dx.doi.org/10.1109/gtec.2011.6167654.

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Sprynsian, Tetiana, Lilia Todoriko, and Igor Semianiv. "Evaluation of pulmonary TB treatment efficiency depending on polymorphism of glutathione-S-transferasexenobiotic biotransformation enzyme and on sensitivity profile." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2726.

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Huderson, Ashley C., Mohammad S. Niaz, Samuel E. Adunyah, and Aramandla Ramesh. "Abstract 5459: Benzo(a)pyrene biotransformation enzyme expression, activities and metabolite disposition in ApcMinmouse colon and liver is altered by resveratrol exposure." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5459.

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