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Journal articles on the topic 'Biotransformation enzymes'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Li, Peng, Ruixue Su, Ruya Yin, et al. "Detoxification of Mycotoxins through Biotransformation." Toxins 12, no. 2 (2020): 121. http://dx.doi.org/10.3390/toxins12020121.

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Mycotoxins are toxic fungal secondary metabolites that pose a major threat to the safety of food and feed. Mycotoxins are usually converted into less toxic or non-toxic metabolites through biotransformation that are often made by living organisms as well as the isolated enzymes. The conversions mainly include hydroxylation, oxidation, hydrogenation, de-epoxidation, methylation, glycosylation and glucuronidation, esterification, hydrolysis, sulfation, demethylation and deamination. Biotransformations of some notorious mycotoxins such as alfatoxins, alternariol, citrinin, fomannoxin, ochratoxins

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2

Taylor, I. N., R. C. Brown, M. Bycroft, et al. "Application of thermophilic enzymes in commercial biotransformation processes." Biochemical Society Transactions 32, no. 2 (2004): 290–92. http://dx.doi.org/10.1042/bst0320290.

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Biocatalysis is a useful tool in the provision of chiral technology and extremophilic enzymes are just one component in that toolbox. Their role is not always attributable to their extremophilic properties; as with any biocatalyst certain other criteria should be satisfied. Those requirements for a useful biocatalyst will be discussed including issues of selectivity, volume efficiency, security of supply, technology integration, intellectual property and regulatory compliance. Here we discuss the discovery and commercialization of an l-aminoacylase from Thermococcus litoralis, the product of a

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3

Serra, Stefano. "Enzyme-Mediated Synthesis of Sesquiterpenes." Natural Product Communications 10, no. 1 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000136.

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This review article focuses mainly on the scientific developments concerning the enzyme-mediated synthesis of sesquiterpenes which have been reported in the academic and patent literature during the last twenty years. Nevertheless, this is not a comprehensive description of every single biotransformation involving sesquiterpenes. Only synthetic approaches that have represented a new and innovative perspective from a scientific standpoint are reported. More specifically, the review describes in depth how the use of metabolic engineering of the microbial biotransformations and of the isolated en

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Sakamoto, Takeshi, John M. Joern, Akira Arisawa, and Frances H. Arnold. "Laboratory Evolution of Toluene Dioxygenase To Accept 4-Picoline as a Substrate." Applied and Environmental Microbiology 67, no. 9 (2001): 3882–87. http://dx.doi.org/10.1128/aem.67.9.3882-3887.2001.

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ABSTRACT We are using directed evolution to extend the range of dioxygenase-catalyzed biotransformations to include substrates that are either poorly accepted or not accepted at all by the naturally occurring enzymes. Here we report on the oxidation of a heterocyclic substrate, 4-picoline, by toluene dioxygenase (TDO) and improvement of the enzyme's activity by laboratory evolution. The biotransformation of 4-picoline proceeds at only ∼4.5% of the rate of the natural reaction on toluene. Random mutagenesis, saturation mutagenesis, and screening directly for product formation using a modified G

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Noten, J. B. G. M., W. M. A. Verhoeven, S. Tuinier, and D. Touw. "Therapeutic drug monitoring." Acta Neuropsychiatrica 11, no. 1 (1999): 15–16. http://dx.doi.org/10.1017/s0924270800036309.

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SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2. Knowledge about the involvement of these enzymes and biotransformation processes is mandatory because of the individual variability in their metabolic capacity. Regular measurement of plasmaconcentrations of (psycho)pharmacological compounds is therefore essential. In addition, the potential value of pheno- and/or ge

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6

Kazenwadel, F., H. Wagner, B. E. Rapp, and M. Franzreb. "Optimization of enzyme immobilization on magnetic microparticles using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as a crosslinking agent." Analytical Methods 7, no. 24 (2015): 10291–98. http://dx.doi.org/10.1039/c5ay02670a.

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7

Hickey, A. M., L. Marle, T. McCreedy, P. Watts, G. M. Greenway, and J. A. Littlechild. "Immobilization of thermophilic enzymes in miniaturized flow reactors." Biochemical Society Transactions 35, no. 6 (2007): 1621–23. http://dx.doi.org/10.1042/bst0351621.

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The exploitation of enzymes for biotransformation reactions for the production of new and safer drug intermediates has been the focus of much research. While a number of enzymes are commercially available, their use in an industrial setting is often limited to reactions that are cost-effective and they are rarely investigated further. However, the development of miniaturized flow reactor technology has meant that the cost of such research, once considered cost- and time-inefficient, would be much less prohibitive. The use of miniaturized flow reactors for enzyme screening offers a number of ad

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8

Bhosale, Sanjyot, Ganesh Saratale, and Sanjay Govindwar. "Biotransformation enzymes inCunninghamella blakesleeana (NCIM-687)." Journal of Basic Microbiology 46, no. 6 (2006): 444–48. http://dx.doi.org/10.1002/jobm.200510117.

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9

Zhang, Donglu, Thomas H. Pillow, Dian Su, et al. "Biotransformation of ADCs. Pathways and enzymes." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S13. http://dx.doi.org/10.1016/j.dmpk.2018.09.065.

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10

Rekka, Eleni A., Panos N. Kourounakis, and Maria Pantelidou. "Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design." Current Topics in Medicinal Chemistry 19, no. 4 (2019): 276–91. http://dx.doi.org/10.2174/1568026619666190129122727.

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Background: The biotransformation of xenobiotics is a homeostatic defensive response of the body against bioactive invaders. Xenobiotic metabolizing enzymes, important for the metabolism, elimination and detoxification of exogenous agents, are found in most tissues and organs and are distinguished into phase I and phase II enzymes, as well as phase III transporters. The cytochrome P450 superfamily of enzymes plays a major role in the biotransformation of most xenobiotics as well as in the metabolism of important endogenous substrates such as steroids and fatty acids. The activity and the poten

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11

Williams, Richard E., Deborah A. Rathbone, Nigel S. Scrutton, and Neil C. Bruce. "Biotransformation of Explosives by the Old Yellow Enzyme Family of Flavoproteins." Applied and Environmental Microbiology 70, no. 6 (2004): 3566–74. http://dx.doi.org/10.1128/aem.70.6.3566-3574.2004.

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ABSTRACT Several independent studies of bacterial degradation of nitrate ester explosives have demonstrated the involvement of flavin-dependent oxidoreductases related to the old yellow enzyme (OYE) of yeast. Some of these enzymes also transform the nitroaromatic explosive 2,4,6-trinitrotoluene (TNT). In this work, catalytic capabilities of five members of the OYE family were compared, with a view to correlating structure and function. The activity profiles of the five enzymes differed substantially; no one compound proved to be a good substrate for all five enzymes. TNT is reduced, albeit slo

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12

Khudolei, Veniamin V. "Genes and enzymes of metabolic activation of xenobiotics in chemical carcinogenesis." Ecological genetics 1, no. 1 (2003): 30–35. http://dx.doi.org/10.17816/ecogen1030-35.

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In the initial stage of chemical carcinogenesis the primary key event is metabolic activation of exogenic carcinogenic substances. The main enzymes of carcinogen's biotransformation (microsomal hydroxylation, reactions of conjugation) and genes which controlling the activity of these enzymes, has been characterized. The tissue(organ)specificity of expression of gene products (isoforms of su-perfamilies of CYPs and GSTs, family of NATs) as well as genetic polymorphism of enzymes involving into the biotransformation of carcinogenic xenobiotics were demonstrated

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13

Wang, Pengcheng, Amina I. Shehu, Ke Liu, Jie Lu, and Xiaochao Ma. "Biotransformation of Cobicistat: Metabolic Pathways and Enzymes." Drug Metabolism Letters 10, no. 2 (2016): 111–23. http://dx.doi.org/10.2174/1872312810666160303112212.

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14

Velı́k, J., V. Baliharová, J. Fink-Gremmels, S. Bull, J. Lamka, and L. Skálová. "Benzimidazole drugs and modulation of biotransformation enzymes." Research in Veterinary Science 76, no. 2 (2004): 95–108. http://dx.doi.org/10.1016/j.rvsc.2003.08.005.

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15

Bhalla, Tek Chand, Vijay Kumar, Virender Kumar, Neerja Thakur, and Savitri. "Nitrile Metabolizing Enzymes in Biocatalysis and Biotransformation." Applied Biochemistry and Biotechnology 185, no. 4 (2018): 925–46. http://dx.doi.org/10.1007/s12010-018-2705-7.

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16

Pearce, R. "Role of CYP3A enzymes in fluticasone biotransformation." Clinical Pharmacology & Therapeutics 75, no. 2 (2004): P84. http://dx.doi.org/10.1016/j.clpt.2003.11.320.

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17

Xia, Yu, Qianqian Cheng, Wanmeng Mu, et al. "Research Advances of d-allulose: An Overview of Physiological Functions, Enzymatic Biotransformation Technologies, and Production Processes." Foods 10, no. 9 (2021): 2186. http://dx.doi.org/10.3390/foods10092186.

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d-allulose has a significant application value as a sugar substitute, not only as a food ingredient and dietary supplement, but also with various physiological functions, such as improving insulin resistance, anti-obesity, and regulating glucolipid metabolism. Over the decades, the physiological functions of d-allulose and the corresponding mechanisms have been studied deeply, and this product has been applied to various foods to enhance food quality and prolong shelf life. In recent years, biotransformation technologies for the production of d-allulose using enzymatic approaches have gained m

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18

Kurze, Elisabeth, Victoria Ruß, Nadia Syam, et al. "Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants." Molecules 26, no. 18 (2021): 5511. http://dx.doi.org/10.3390/molecules26185511.

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Menthol is a cyclic monoterpene alcohol of the essential oils of plants of the genus Mentha, which is in demand by various industries due to its diverse sensorial and physiological properties. However, its poor water solubility and its toxic effect limit possible applications. Glycosylation offers a solution as the binding of a sugar residue to small molecules increases their water solubility and stability, renders aroma components odorless and modifies bioactivity. In order to identify plant enzymes that catalyze this reaction, a glycosyltransferase library containing 57 uridine diphosphate s

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19

Ben-Arie, N., M. Khen, and D. Lancet. "Glutathione S-transferases in rat olfactory epithelium: purification, molecular properties and odorant biotransformation." Biochemical Journal 292, no. 2 (1993): 379–84. http://dx.doi.org/10.1042/bj2920379.

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The olfactory epithelium is exposed to a variety of xenobiotic chemicals, including odorants and airborne toxic compounds. Recently, two novel, highly abundant, olfactory-specific biotransformation enzymes have been identified: cytochrome P-450olf1 and olfactory UDP-glucuronosyltransferase (UGT(olf)). The latter is a phase II biotransformation enzyme which catalyses the glucuronidation of alcohols, thiols, amines and carboxylic acids. Such covalent modification, which markedly affects lipid solubility and agonist potency, may be particularly important in the rapid termination of odorant signal

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20

Holland, Herbert L., Cynthia G. Rand, Peter Viski, and Frances M. Brown. "Microbial oxidation of benzyl sulfides and bibenzyl by Mortierella isabellina and Helminthosporium species." Canadian Journal of Chemistry 69, no. 12 (1991): 1989–93. http://dx.doi.org/10.1139/v91-287.

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The biotransformation of 1,2-diphenylethane by the fungus Mortierella isabellina ATCC 42613, and that of a series of alkyl benzyl sulfides by the fungi M. isabellina and Helminthosporium species NRRL 4671 have been studied. Mortierella hydroxylates 1,2-diphenylethane in low yield, giving (S)-1,2-diphenylethanol with an enantiomeric purity of 33%. Bioconversions of deuterium-labelled and racemic 1,2-diphenylethanol by M. isabellina demonstrate that this organism performs reversible oxidation/reduction of the alcohol. Biotransformations of n-alkyl benzyl sulfides by H. species give predominantly

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21

Pavlović, Sladjan, Slavica Borković-Mitić, Tijana Radovanović, et al. "Antioxidant enzymes in the liver of Chelidonichthys obscurus from the Montenegrin coastline." Open Life Sciences 8, no. 8 (2013): 747–55. http://dx.doi.org/10.2478/s11535-013-0179-0.

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AbstractThe activities of antioxidant defence enzymes — total, manganese and copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) — in the liver of longfin gurnard (Chelidonichthys obscurus) from the Montenegrin coastline (Adriatic sea) were investigated. The specimens were collected in winter (February) and late spring (May) at two localities: Platamuni (PL, potentially unpolluted) and the Estuary of the River Bojana (EB, potenti

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22

Mirzaev, Karin B., Denis S. Fedorinov, Dmitry V. Ivashchenko, and Dmitry A. Sychev. "ADME pharmacogenetics: future outlook for Russia." Pharmacogenomics 20, no. 11 (2019): 847–65. http://dx.doi.org/10.2217/pgs-2019-0013.

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This systematic review reflects the results of pharmacogenetic studies in the Russian Federation aimed at studying the genes involved in the drug biotransformation system. The works of Russian researchers found by us are mostly devoted to microsomal liver oxidation enzymes (metabolism) and membrane transporter systems (absorption and excretion). This review presents population-ethnic and associative clinical studies on the genes of the CYP450 system, noncytochrome oxidation enzymes ( SULT1A1, CES1), membrane transporter system genes ( ABCB1, SLCO1B1) and warfarin biotransformation enzymes ( VK

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23

Modriansky, Martin, and Zdenek Dvorak. "MICROTUBULE DISRUPTORS AND THEIR INTERACTION WITH BIOTRANSFORMATION ENZYMES." Biomedical Papers 149, no. 2 (2005): 213–15. http://dx.doi.org/10.5507/bp.2005.028.

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24

Borges, Warley de, Keyller Borges, Pierina Bonato, Suraia Said, and Monica Pupo. "Endophytic Fungi: Natural Products, Enzymes and Biotransformation Reactions." Current Organic Chemistry 13, no. 12 (2009): 1137–63. http://dx.doi.org/10.2174/138527209788921783.

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25

Wang, Pengcheng, Junjie Zhu, Amina I. Shehu, et al. "Enzymes and Pathways of Kavain Bioactivation and Biotransformation." Chemical Research in Toxicology 32, no. 7 (2019): 1335–42. http://dx.doi.org/10.1021/acs.chemrestox.9b00098.

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26

Gonzalez-Gil, Lorena, Daniel Krah, Ann-Kathrin Ghattas, et al. "Biotransformation of organic micropollutants by anaerobic sludge enzymes." Water Research 152 (April 2019): 202–14. http://dx.doi.org/10.1016/j.watres.2018.12.064.

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27

Šarmanová, Jana, Simona Šůsová, Ivan Gut, et al. "Breast cancer: role of polymorphisms in biotransformation enzymes." European Journal of Human Genetics 12, no. 10 (2004): 848–54. http://dx.doi.org/10.1038/sj.ejhg.5201249.

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28

washburn, B. S., K. Tullis, M. S. Denison, et al. "Brevetoxin: Biotransformation and effects on xenobiotic metabolizing enzymes." Marine Environmental Research 42, no. 1-4 (1996): 282. http://dx.doi.org/10.1016/0141-1136(96)87081-4.

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29

Diaz-Diaz, M., O. P. Ward, J. Honek, and G. Lajoie. "Enzymes from Pseudomonas sp. strain NCIB 11097 participating in biotransformation of acetaldehyde and glycine to threonine isomers." Canadian Journal of Microbiology 41, no. 4-5 (1995): 438–43. http://dx.doi.org/10.1139/m95-059.

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Enzyme activities involved in L-threonine bioconversions present in cells of Pseudomonas sp. strain NCIB 11097 were separated by phenyl-Sepharose hydrophobic chromatography. The separation of the two main activity components was monitored by discontinuous polyacrylamide gel electrophoresis. Threonine aldolase catalyzed the conversion of glycine and acetaldehyde to a mixture of isomers, L-threonine and L-allothreonine, in a biotransformation reaction having pH and temperature optima of 7.5 and 25–30 °C, respectively. The fraction containing serine hydroxymethyltransferase converted acetaldehyde

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30

Burton, Stephanie G. "Development of bioreactors for application of biocatalysts in biotransformations and bioremediation." Pure and Applied Chemistry 73, no. 1 (2001): 77–83. http://dx.doi.org/10.1351/pac200173010077.

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Biotransformation systems, whether used for environmentally benign biocatalysis of synthetic reactions, or bioremediation of pollutants, require suitable biocatalysts and suitable bioreactor systems with particular characteristics. Our research focuses on the bioconversion of organic compounds, many of which are industrial residues, such as phenols, poly-aromatic hydrocarbons, heterocyclic compounds, and polychlorinated biphenyls. The purpose of such biotransformations can be twofold: firstly, to remove them from effluents and convert them to less toxic forms, and secondly, to convert them int

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Bhushan, Bharat, Louise Paquet, Jim C. Spain, and Jalal Hawari. "Biotransformation of 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-Hexaazaisowurtzitane (CL-20) by Denitrifying Pseudomonas sp. Strain FA1." Applied and Environmental Microbiology 69, no. 9 (2003): 5216–21. http://dx.doi.org/10.1128/aem.69.9.5216-5221.2003.

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ABSTRACT The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerob

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32

Kohalmy, Krisztina, and Radim Vrzal. "Regulation of Phase II Biotransformation Enzymes by Steroid Hormones." Current Drug Metabolism 12, no. 2 (2011): 104–23. http://dx.doi.org/10.2174/138920011795016872.

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Cabral, J. M. S., M. R. Aires-Barros, H. Pinheiro, and D. M. F. Prazeres. "Biotransformation in organic media by enzymes and whole cells." Journal of Biotechnology 59, no. 1-2 (1997): 133–43. http://dx.doi.org/10.1016/s0168-1656(97)00176-4.

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Van Bladeren, PJ. "Influence of non-nutrient plant components on biotransformation enzymes." Biomedicine & Pharmacotherapy 51, no. 8 (1997): 324–27. http://dx.doi.org/10.1016/s0753-3322(97)88049-3.

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Georgieva, N. "Ligninolytic Enzymes Produced byPhanerohaete Chrysosporium 1038and Biotransformation of Lignin." Biotechnology & Biotechnological Equipment 23, sup1 (2009): 844–47. http://dx.doi.org/10.1080/13102818.2009.10818554.

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Crawford, Don L., and Eric P. Nielsen. "Biotransformation of coal substructure model compounds by microbial enzymes." Applied Biochemistry and Biotechnology 54, no. 1-3 (1995): 223–31. http://dx.doi.org/10.1007/bf02787921.

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Lee, Fu Haw, Suet Ying Wan, Hooi Ling Foo, et al. "Comparative Study of Extracellular Proteolytic, Cellulolytic, and Hemicellulolytic Enzyme Activities and Biotransformation of Palm Kernel Cake Biomass by Lactic Acid Bacteria Isolated from Malaysian Foods." International Journal of Molecular Sciences 20, no. 20 (2019): 4979. http://dx.doi.org/10.3390/ijms20204979.

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Biotransformation via solid state fermentation (SSF) mediated by microorganisms is a promising approach to produce useful products from agricultural biomass. Lactic acid bacteria (LAB) that are commonly found in fermented foods have been shown to exhibit extracellular proteolytic, β-glucosidase, β-mannosidase, and β-mannanase activities. Therefore, extracellular proteolytic, cellulolytic, and hemicellulolytic enzyme activities of seven Lactobacillus plantarum strains (a prominent species of LAB) isolated from Malaysian foods were compared in this study. The biotransformation of palm kernel cak

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Segner, Helmut, and Jean-Pierre Cravedi. "Metabolic Activity in Primary Cultures of Fish Hepatocytes." Alternatives to Laboratory Animals 29, no. 3 (2001): 251–57. http://dx.doi.org/10.1177/026119290102900321.

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In aquatic toxicology, isolated liver cells from fish can be used as a tool to generate initial information on the hepatic metabolism of xenobiotics, and on the mechanisms of xenobiotic activation or deactivation. This isolation of teleost liver cells is achieved by enzymic dissociation, and monolayer cultures of fish hepatocytes in serum-free medium maintain good viability for 3–8 days. During in vitro culture, fish liver cells express stable levels of phase I and phase II enzymes, such as cytochrome P4501A or glutathione S-transferase, and the cells show an induction of biotransformation enz

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Pereira dos Santos, Valmore Henrique, Dorval Moreira Coelho Neto, Valdemar Lacerda Júnior, Warley de Souza Borges, and Eliane de Oliveira Silva. "Fungal Biotransformation: An Efficient Approach for Stereoselective Chemical Reactions." Current Organic Chemistry 24, no. 24 (2020): 2902–53. http://dx.doi.org/10.2174/1385272824999201111203506.

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Abstract:: There is great interest in developing chemical technologies to achieve regioselective and stereoselective reactions since only one enantiomer is required for producing the chiral leads for drug development. These selective reactions are provided by traditional chemical synthetic methods, even under expensive catalysts and long reaction times. Filamentous fungi are efficient biocatalysts capable of catalyzing a wide variety of reactions with significant contributions to the development of clean and selective processes. Although some enzymes have already been employed in isolated form

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Karimov, Kh, and Yu Assesorova. "ROLE OF GSTM AND GSTT POLYMORPHIC GENES IN ONCOGENESIS AND THE ONSET OF HEMATOLOGIC NEOPLASMS." Problems in oncology 66, no. 5 (2020): 472–78. http://dx.doi.org/10.37469/0507-3758-2020-66-5-472-478.

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Throughout life, a person is exposed to various xenobiotics, one of the biological effects of which is the genotoxic effect, leading to the occurrence of oncogenic mutations. Mutagenic and promutagenic substances can be detoxified with the corresponding xenobiotic biotransformation enzymes, however, if the enzymatic activity of the latter changes, the neutralization of the mutagens occurs at a slower pace. The review discusses the polymorphic genes of enzymes of the second phase of the biotransformation of xenobiotics of the GSTS family and presents modern literature data on the role of GSTM a

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Makaji, Emilija, Shirley H. Y. Ho, Alison C. Holloway, and Denis J. Crankshaw. "Effects in Rats of Maternal Exposure to Raspberry Leaf and Its Constituents on the Activity of Cytochrome P450 Enzymes in the Offspring." International Journal of Toxicology 30, no. 2 (2010): 216–24. http://dx.doi.org/10.1177/1091581810388307.

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The goal of our study was to determine whether maternal exposure to red raspberry leaf (RRL) and its constituents can permanently alter biotransformation of fluorogenic substrates by cytochrome P450 (CYP) in the livers of male and female offspring. Nulliparous female rats received vehicle, raspberry leaf, kaempferol, quercetin, or ellagic acid orally once breeding had been confirmed until parturition. Hepatic microsomes were prepared from animals at birth (postnatal day 1 [PND1]), weaning (PND21), PND65, and PND120 to determine the biotransformation of 8 fluorogenic substrates. The pattern of

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Falcone, Shao, Rashid, and Kraatz. "Enzyme Entrapment in Amphiphilic Myristyl-Phenylalanine Hydrogels." Molecules 24, no. 16 (2019): 2884. http://dx.doi.org/10.3390/molecules24162884.

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Supramolecular amino acid and peptide hydrogels are functional materials with a wide range of applications, however, their ability to serve as matrices for enzyme entrapment have been rarely explored. Two amino acid conjugates were synthesized and explored for hydrogel formation. These hydrogels were characterized in terms of strength and morphology, and their ability to entrap enzymes while keeping them active and reusable was explored. It was found that the hydrogels were able to successfully entrap two common and significant enzymes—horseradish peroxidase and -amylase—thus keeping them act

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Lamka, J., V. Krizova, V. Cvilink, et al. "A single adulticide dose of albendazole induces cytochromes P4501A in mouflon (Ovis musimon) with dicrocoeliosis." Veterinární Medicína 52, No. 8 (2008): 343–52. http://dx.doi.org/10.17221/1873-vetmed.

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Contact handling with wild or semi-domesticated animals requires limiting animal stress to minimum. In this respect, single administration of drug should be preferred in contact therapy of mouflon (<i>Ovis musimon</i>) infected by lancet fluke (<i>Dicrocoelium dendriticum</i>). We tested single administration of albendazole (ABZ) (30 mg/kg of body weight) in a form of oral suspension and investigated to reach anthelmintic effects and to modulate biotransformation enzymes in liver and small intestine. Two weeks after ABZ administration coprology and necropsy findings doc

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Wen, Jikai, Peiqiang Mu, and Yiqun Deng. "Mycotoxins: cytotoxicity and biotransformation in animal cells." Toxicology Research 5, no. 2 (2016): 377–87. http://dx.doi.org/10.1039/c5tx00293a.

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Mycotoxins can be biotransformed by phase I and phase II enzymes in animals. However, most of the mycotoxin at high dosage combined with their metabolites can cause carcinogenesis and various cytotoxicity, such as apoptosis, lipids oxidation and cell cycle arrest,etc., and most of which are related to oxidative stress.

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Sousa, C., P. B. Andrade, and P. Valentão. "Relationships of Echium plantagineum L. bee pollen, dietary flavonoids and their colonic metabolites with cytochrome P450 enzymes and oxidative stress." RSC Advances 6, no. 8 (2016): 6084–92. http://dx.doi.org/10.1039/c5ra26736f.

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Echium plantagineumL. bee pollen is a dietary source of flavonoids, which can play a protective role in the gastrointestinal tract by modulating cytochrome P450 (CYP) biotransformation enzymes and by opposing oxidative stress.

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Stuthridge, T. R., S. M. Anderson, J. S. Gifford, M. J. Robinson, and D. L. Straus. "Bioaccumulation of dehydroabietic acid in rainbow trout (Oncorhynchus mykiss): role of biotransformation enzymes." Water Science and Technology 35, no. 2-3 (1997): 365–72. http://dx.doi.org/10.2166/wst.1997.0559.

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The role of Phase I and Phase II metabolism in rainbow trout on the bioaccumulation of dehydroabietic acid, an abundant and persistent compound found in pulp and paper mill effluents, was investigated using known inducer/inhibitor compounds for cytochromes P450 (P450s), ethoxyresorufin O-deethylase (EROD) and uridine diphosphoglucuronosyltransferase (UDPGT). The inducer/inhibitor compounds consisted of piperonyl butoxide (PBO), salicylamide (SAL) and β-naphthoflavone (βNF). PBO induced EROD, SAL had no effect on the measured biotransformation enzyme activities and βNF induced EROD and UDPGT. T

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Zor, Ceren, Holly A. Reeve, Jonathan Quinson, et al. "H2-Driven biocatalytic hydrogenation in continuous flow using enzyme-modified carbon nanotube columns." Chemical Communications 53, no. 71 (2017): 9839–41. http://dx.doi.org/10.1039/c7cc04465h.

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NEBBIA, C. "Biotransformation Enzymes as Determinants of Xenobiotic Toxicity in Domestic Animals." Veterinary Journal 161, no. 3 (2001): 238–52. http://dx.doi.org/10.1053/tvjl.2000.0561.

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Samuelsen, J. T., J. A. Holme, M. Låg, P. E. Schwarze, J. E. Dahl, and R. Becher. "Biotransformation enzymes and lung cell response to 2-hydroxyethyl-methacrylate." Journal of Biomedical Materials Research Part A 100A, no. 2 (2011): 462–69. http://dx.doi.org/10.1002/jbm.a.33287.

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Illgner, Sascha, and Rudolf Matusch. "Biotransformation of Desoxypeganine by Microsomal Enzymes of the Rabbit Liver." Archiv der Pharmazie 338, no. 1 (2005): 49–52. http://dx.doi.org/10.1002/ardp.200400921.

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