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Journal articles on the topic 'Biphasic pattern'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kovtyuk, N., Yu Nechytailo, D. Nechytailo та T. Mikhieieva. "Стереотипы сна у детей школьного возраста". Педиатрия. Восточная Европа, № 2 (17 червня 2021): 217–23. http://dx.doi.org/10.34883/pi.2021.9.2.006.

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Introduction. Sleep is very important to human health and well-being, and sleep loss and disorders are associated with a wide range of adverse health effects, especially in children.Purpose. To assess sleep peculiarities and sleep patterns in children.Materials and methods. In total, 562 children aged 10–18 years were examined. Assessment of anthropometric data, nutrition, physical activity, sleep peculiarities and quality, family and socioeconomic data etc. was conducted. Circadian rhythm chronotype was also assessed with the standard questionnaire for determination of the chronotypes (mornin

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Recho, Pierre, Adrien Hallou, and Edouard Hannezo. "Theory of mechanochemical patterning in biphasic biological tissues." Proceedings of the National Academy of Sciences 116, no. 12 (2019): 5344–49. http://dx.doi.org/10.1073/pnas.1813255116.

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The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and diffusion, which impact cell differentiation and tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase consists of a poroelastic cell network and the other one of a permeating extracellular fluid, which provides

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Saeed, Zeba, Zainab Hasan, and Maria Atif. "SLEEP PATTERNS OF MEDICAL STUDENTS." Professional Medical Journal 22, no. 07 (2015): 919–23. http://dx.doi.org/10.29309/tpmj/2015.22.07.1183.

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Objectives: To identify sleep patterns of medical students and determinethe relationship between sleep habits and academic performance. Background: Humanbeings adopt three different sleeping patterns; monophasic, biphasic and polyphasic. Sleepallows synaptic molding to return by developing faster memory union. When such memoryprocessing is not present, memory keeping is reduced which can have an adverse effecton the academic performance of students. Professional education in the field of medicinerequires learning a greater amount and variety of syllabi to practice as a satisfactory medicalgrad

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Hering, Angelkort, Keck, Wilde, and Amann. "Long-term outcome of successful percutaneous transluminal angioplasty of the fibular artery in diabetic foot syndrome and single-vessel calf perfusion depends on doppler wave pattern at the forefoot." Vasa 39, no. 1 (2010): 67–75. http://dx.doi.org/10.1024/0301-1526/a000007.

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Background: In the diabetic foot syndrome (DFS) due to peripheral artery disease, the fibular artery is often the only vessel which can be revascularised. Because the fibular artery does not have a direct connection to the plantar arch, the clinical result of fibular artery PTA is dependent upon the extent of collateralization at the ankle. Therefore, successful PTA of the fibular artery with resulting biphasic doppler waves at the ankle can lead to either biphasic or monophasic post-occlusive doppler wave patterns at the forefoot. We evaluated prospectively the association of the forefoot dop

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Shishehbor, Farideh, Helen M. Roche, and Michael J. Gibney. "The effect of acute carbohydrate load on the monophasic or biphasic nature of the postprandial lipaemic response to acute fat ingestion in human subjects." British Journal of Nutrition 80, no. 5 (1998): 411–18. http://dx.doi.org/10.1017/s0007114598001470.

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Previous studies in this laboratory have elicited a monophasic response in postprandial plasma triacylglycerol (TAG) level with fat intakes of 0.5 g fat/kg body weight accompanied by about 17 g carbohydrate as lactose. Recent studies involving the same level of fat with a higher level of carbohydrate, 136 g of which 60 g was sucrose, appeared to elicit a biphasic response. The present study compared these two test meals and showed a significant meal × time interaction for plasma total TAG (P = 0.0228) reflecting a monophasic response with the lower-carbohydrate test meal. The higher-carbohydra

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Ruddell, A., and M. Jacobs-Lorena. "Biphasic pattern of histone gene expression during Drosophila oogenesis." Proceedings of the National Academy of Sciences 82, no. 10 (1985): 3316–19. http://dx.doi.org/10.1073/pnas.82.10.3316.

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Hoedemaekers, Cornelia W., Marcel van Deuren, and Johannes G. van der Hoeven. "Complement Activation After Cardiac Surgery Follows a Biphasic Pattern." Annals of Thoracic Surgery 86, no. 5 (2008): 1723. http://dx.doi.org/10.1016/j.athoracsur.2008.05.029.

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Ikegami, Tetsunori, Michael Ji, Naoyuki Fujimura, Jenny V. Suneby Jagers, Teresa M. Kieser, and Paul A. Easton. "Costal and crural diaphragm function during sustained hypoxia in awake canines." Journal of Applied Physiology 126, no. 4 (2019): 1117–28. http://dx.doi.org/10.1152/japplphysiol.00242.2018.

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In humans and other mammals, isocapnic hypoxia sustained for 20–60 min exhibits a biphasic ventilation pattern: initial increase followed by a significant ventilatory decline (“roll-off”) to a lesser intermediate plateau. During sustained hypoxia, the mechanical action and activity of the diaphragm have not been studied; thus we assessed diaphragm function in response to hypoxic breathing. Thirteen spontaneously breathing awake canines were exposed to moderate levels of sustained isocapnic hypoxia lasting 20–25 min (80 ± 2% pulse oximeter oxygen saturation). Breathing pattern and changes in mu

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Yamaguchi, Ayako, David Gooler, Amy Herrold, Shailja Patel, and Winnie W. Pong. "Temperature-Dependent Regulation of Vocal Pattern Generator." Journal of Neurophysiology 100, no. 6 (2008): 3134–43. http://dx.doi.org/10.1152/jn.01309.2007.

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Vocalizations of Xenopus laevis are generated by central pattern generators (CPGs). The advertisement call of male X. laevis is a complex biphasic motor rhythm consisting of fast and slow trills (a train of clicks). We found that the trill rate of these advertisement calls is sensitive to temperature and that this rate modification of the vocal rhythms originates in the central pattern generators. In vivo the rates of fast and slow trills increased linearly with an increase in temperature. In vitro a similar linear relation between temperature and compound action potential frequency in the lar

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Zhu, Xuan, Liang Shi, Pengcheng Li, and Jinling Lu. "Cerebral blood flow patterns induced by photoactivation based on laser speckle contrast imaging." Biomedical Optics Express 15, no. 12 (2024): 6739. http://dx.doi.org/10.1364/boe.541444.

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Neurovascular coupling (NVC) is crucial for maintaining brain function and holds significant implications for diagnosing neurological disorders. However, the neuron type and spatial specificity in NVC remain poorly understood. In this study, we investigated the spatiotemporal characteristics of local cerebral blood flow (CBF) driven by excitatory (VGLUT2) and inhibitory (VGAT) neurons in the mouse sensorimotor cortex. By integrating optogenetics, wavefront modulation technology, and laser speckle contrast imaging (LSCI), we achieved precise, spatially targeted photoactivation of type-specific

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Lapić, Ivana, Ana Lončar Vrančić, Désirée Coen Herak, and Dunja Rogić. "The missing slope: paradoxical shortening of activated partial thromboplastin time in a patient on unfractionated heparin therapy." Biochemia medica 31, no. 2 (2021): 372–76. http://dx.doi.org/10.11613/bm.2021.021003.

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This case report describes false shortening of activated partial thromboplastin time (aPTT) due to erroneous optical reading of the clotting point in the presence of unfractionated heparin (UFH), and a biphasic waveform. Activated partial thromboplastin time performed on a coagulometer with photo-optical detection yielded an ambiguous clotting curve characterized by an early and steady decrease in light transmittance throughout the whole measuring range, with the clotting point read at 65 seconds. Further investigations included measurement of aPTT by means of a mechanical clot detection metho

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Schmidt-Kassow, Maren, and Sonja A. Kotz. "Event-related Brain Potentials Suggest a Late Interaction of Meter and Syntax in the P600." Journal of Cognitive Neuroscience 21, no. 9 (2009): 1693–708. http://dx.doi.org/10.1162/jocn.2008.21153.

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Many studies refer to the relevance of metric cues in speech segmentation during language acquisition and adult language processing. However, the on-line use (i.e., time-locking the unfolding of a sentence to EEG) of metric stress patterns that are manifested by the succession of stressed and unstressed syllables during auditory syntactic processing has not been investigated. This is surprising as both processes rely on abstract rules that allow the building up of expectancies of which element will occur next and at which point in time. Participants listened to metrically regular sentences tha

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Jalleh, Ryan J., Chinmay S. Marathe, Laurence G. Trahair, Karen L. Jones, and Michael Horowitz. "A Biphasic Glucose Response during an Oral Glucose Tolerance Test Is Associated with Greater Plasma Insulin and GLP-1 Responses and a Reduction in 1-Hour Glucose but Does Not Relate to the Rate of Gastric Emptying in Healthy, Older Adults." Nutrients 15, no. 18 (2023): 3889. http://dx.doi.org/10.3390/nu15183889.

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Background: The pattern of the plasma glucose response curve during an oral glucose tolerance test (OGTT) is of prognostic significance with “biphasic” when compared with “monophasic” patterns being associated with greater insulin sensitivity/secretion and a reduced risk of progression to diabetes. The relationships of the glucose response curves with gastric emptying and incretin hormone secretion are not known. Methods: Thirty-six adults (age > 65 years) without known diabetes consumed a 300 mL drink containing 75 g glucose and 150 mg C13-acetate at baseline and follow-up after 5.8 ± 0.1

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Rorsman, Patrik, Lena Eliasson, Erik Renström, Jesper Gromada, Sebastian Barg, and Sven Göpel. "The Cell Physiology of Biphasic Insulin Secretion." Physiology 15, no. 2 (2000): 72–77. http://dx.doi.org/10.1152/physiologyonline.2000.15.2.72.

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Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.

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Richardson, S., S. Twente, and T. Audhya. "GHRF causes biphasic stimulation of SRIF secretion from rat hypothalamic cells." American Journal of Physiology-Endocrinology and Metabolism 255, no. 6 (1988): E829—E832. http://dx.doi.org/10.1152/ajpendo.1988.255.6.e829.

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The complex interactions of the hypothalamic releasing peptides somatostatin (SRIF) and growth hormone (GH)-releasing hormone (GHRF), which regulate GH secretion, are still incompletely understood. To further scrutinize these interactions, we have studied the effects of GHRF on SRIF secretion from dispersed adult rat hypothalamic cells. Rat GHRF caused calcium- and dose-dependent stimulation of SRIF release in static 1-h incubations. SRIF release was stimulated by GHRF in a concentration range of 1-100 nM. However, the extended dose-response curve was biphasic in nature, with a significantly l

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Srinivasan, M., H. Lagercrantz, and Y. Yamamoto. "A possible dopaminergic pathway mediating hypoxic depression in neonatal rabbits." Journal of Applied Physiology 67, no. 3 (1989): 1271–76. http://dx.doi.org/10.1152/jappl.1989.67.3.1271.

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Previous studies show a differential effect of dopamine and its agonist apomorphine on ventilation, being depressant on adults and stimulatory on fetal respiratory breathing movements. In view of this we studied the effect of apomorphine, specific antagonists of dopamine receptors SCH 23390 (D1), sulpiride and domperidone (D2), and cis(z)-flupentixol (D1 + D2) on the typical ventilatory response to hypoxia in neonatal rabbit pups. This ventilatory response to hypoxia is characterized by an initial stimulatory (phase 1) followed by a declining (phase 2) pattern. Cis(z)-flupentixol markedly incr

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Abelenda-Alonso, Gabriela, Ariadna Padullés, Alexander Rombauts, et al. "Antibiotic prescription during the COVID-19 pandemic: A biphasic pattern." Infection Control & Hospital Epidemiology 41, no. 11 (2020): 1371–72. http://dx.doi.org/10.1017/ice.2020.381.

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18

Shen, Yang, Xiaodu Wang, Lin Guo, et al. "Influenza A virus induces p53 accumulation in a biphasic pattern." Biochemical and Biophysical Research Communications 382, no. 2 (2009): 331–35. http://dx.doi.org/10.1016/j.bbrc.2009.03.018.

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De Angelis, Gabriella, Monica Moschioni, Alessandro Muzzi, et al. "The Streptococcus pneumoniae Pilus-1 Displays a Biphasic Expression Pattern." PLoS ONE 6, no. 6 (2011): e21269. http://dx.doi.org/10.1371/journal.pone.0021269.

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20

Schübert, Helen, Ulrich A. Müller, Guido Kramer, et al. "Snacking is Common in People with Diabetes Type 1 and Type 2 with Insulin Therapy and Is Not Associated With Metabolic Control or Quality of Life." Experimental and Clinical Endocrinology & Diabetes 127, no. 07 (2018): 461–67. http://dx.doi.org/10.1055/a-0631-8813.

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Abstract Objective The aim of this observational study was to analyse snacking pattern and satisfaction with snacking, and to associate snacking patterns with metabolic control and quality of life in people with diabetes type 1 and 2 on insulin therapy. Methods In 2017, 390 people with diabetes were interviewed in a university outpatient department: 132 diabetes type 1 (56.1y, diabetes duration 24.2y, HbA1c 7.0%), 89 diabetes type 2/biphasic insulin (72.8y, diabetes duration 22.0y, HbA1c 7.1%) and 169 diabetes type 2/prandial insulin (66.7y, diabetes duration 20.5y, HbA1c 7.0%). Standardised q

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Balakrishnan, R., Dipak Ranjan Nayak, Suresh Pillai, and Lakshmi Rao. "Hyalinizing clear cell carcinoma of the base of the tongue." Journal of Laryngology & Otology 116, no. 10 (2002): 851–53. http://dx.doi.org/10.1258/00222150260293718.

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Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC).Most of the HCCC occur in the oral cavity, and are associated with minor salivary glands, unlike the biphasic pattern which is more common in the major salivary glands. In the oral cavity, the common

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Stowe, Shelby, Christina Athanasouli, Monique LeBourgeois, Victoria Booth, and Cecilia Diniz Behn. "0113 Data-Driven Mathematical Modeling of Sleep Consolidation in Early Childhood." SLEEP 46, Supplement_1 (2023): A50—A51. http://dx.doi.org/10.1093/sleep/zsad077.0113.

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Abstract Introduction During early childhood, sleep behavior transitions from a biphasic pattern (daytime nap and nighttime sleep) to a monophasic pattern (nighttime sleep only). The transition to consolidated sleep, occurring in most children between 2- and 5-years old, is a major developmental milestone and reflects interactions between the homeostatic sleep drive and the circadian drive. This study aimed to utilize experimental data and mathematical modeling to determine the contributions of developmentally-mediated changes in the homeostatic sleep drive to the consolidation of sleep observ

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Madjdpour, Lilly, Sita Kneller, Christa Booy, Thomas Pasch, Ralph C. Schimmer, and Beatrice Beck-Schimmer. "Acid-induced Lung Injury." Anesthesiology 99, no. 6 (2003): 1323–32. http://dx.doi.org/10.1097/00000542-200312000-00013.

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Background Aspiration of acidic gastric contents leads to acute lung injury and is still one of the most common clinical events associated with acute lung injury. This study was performed to assess acid-induced lung inflammation in vitro and in vivo with respect to the time pattern of activated transcription factor nuclear factor-kappaB (NF-kappaB) and proinflammatory molecules. Methods L2 cells (alveolar epithelial cells) were exposed for various periods to a medium with a pH of 6. In the in vivo model, 1 ml/kg of 0.1 n acidic solution was instilled into the lungs of rats. NF-kappaB binding a

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Muhammad Salman Rafique, Bushra Bilal, Sana Kundi, Tahir Malik, Kayenat Khan, and Huma Hussain. "Do Respiratory Maneuvers Affect Rght Hepatic Vein Waveform and Maximum Velocity in Post LDLT Recipients?" Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University 19, no. 3 (2023): 289–93. http://dx.doi.org/10.48036/apims.v19i3.688.

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AIM: Â To evaluate the effect of respiratory maneuvers on right hepatic vein (RHV) Doppler waveform and its maximum velocity in Living donor liver transplant (LDLT) recipients. METHODS: This was a prospective cross-sectional study performed at Pakistan Kidney and Liver Institute and Research Centre (PKLI& RC), Lahore Radiology department. The sample size of the study, calculated according to WHO sample size calculator, was 30 patients after applying the inclusion and exclusion criteria. Most of these patients were analyzed during their first post-operative week while staying in the surgica

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Ravishankar, H., and G. Padmanaban. "Turnover of messenger RNA, apoprotein and haem of cytochrome P-450b + e induced by phenobarbitone in rat liver." Biochemical Journal 229, no. 1 (1985): 73–79. http://dx.doi.org/10.1042/bj2290073.

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A single injection of phenobarbitone elicits asynchronous behaviour in the pattern of induction of mRNA, apoprotein and haem of cytochrome P-450b + e. The mRNA content reaches a maximum around 16h, the apoprotein content reaches a maximum around 30-36h, and the holoprotein content shows biphasic behaviour, with maxima around 16h and 30-36h. With the use of CoCl2 to block fresh transcription of cytochrome P-450b + e mRNA, the half-life of the preinduced mRNA was found to be 3h. The apoprotein and haem moieties of cytochrome P-450b + e turn over with half-lives of 16h and 8h respectively. The pa

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Choi, Il-Whan, Young-Suk Kim, Dae-Ki Kim та ін. "Platelet-activating Factor–mediated NF-κB Dependency of a Late Anaphylactic Reaction". Journal of Experimental Medicine 198, № 1 (2003): 145–51. http://dx.doi.org/10.1084/jem.20022129.

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Anaphylaxis is a life-threatening systemic allergic reaction with the potential for a recurrent or biphasic pattern. Despite an incidence of biphasic reaction between 5 and 20%, the molecular mechanism for the reaction is unknown. Using a murine model of penicillin V–induced systemic anaphylaxis, we show an autoregulatory cascade of biphasic anaphylactic reactions. Induction of anaphylaxis caused a rapid increase in circulating platelet-activating factor (PAF) levels. In turn, the elevated PAF contributes to the early phase of anaphylaxis as well as the subsequent activation of the nuclear fac

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Keller, Emma J., Nicole Campbell, Laura M. Davison, Neeva Patel, and Trine N. Jorgensen. "Lupus-like disease in B6.Nba2 mice shows a biphasic disease progression." Journal of Immunology 204, no. 1_Supplement (2020): 219.10. http://dx.doi.org/10.4049/jimmunol.204.supp.219.10.

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Abstract Lupus is an autoimmune disease with a diverse pattern of symptoms affecting approximately 1.5 million Americans. Over the past decade, new biologics (f.ex. Belimumab, Anifrolumab) have emerged targeting cytokines and/or cells known to be pathogenic in lupus, however, response-rates among varied patient populations remain low, supporting the heterogeneity of the disease. B6.Nba2 mice exhibit a constitutive progressive lupus-like disease pattern driven by type I interferons (IFNα). Using this model, ablation of plasmacytoid dendritic cells (pDCs) is effective if initiated before, but no

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Dawson, Ellen A., Daniel J. Green, N. Timothy Cable, and Dick H. J. Thijssen. "Effects of acute exercise on flow-mediated dilatation in healthy humans." Journal of Applied Physiology 115, no. 11 (2013): 1589–98. http://dx.doi.org/10.1152/japplphysiol.00450.2013.

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Although the effects of exercise training on vascular function have been well studied, less is known about the effects of acute exercise bouts. This synthesis summarizes and integrates knowledge derived from papers relating acute impacts of exercise on artery function, specifically endothelial function assessed by flow-mediated dilatation (FMD). We propose that an immediate decrease in FMD (“nadir”) occurs soon after exercise cessation and that this is followed by a (supra)normalization response. The magnitude of the nadir and (supra)normalization and duration of this biphasic pattern of respo

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Riggs, J. E. "The biphasic pattern of age-specific malignant brain tumor mortality rates." Neurology 55, no. 6 (2000): 750–53. http://dx.doi.org/10.1212/wnl.55.6.750.

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Şentürk, Ümit Kemal, Oktay Kuru, Günnur Koçer, and Filiz Gündüz. "Biphasic Pattern of Exercise-Induced Proteinuria in Sedentary and Trained Men." Nephron Physiology 105, no. 2 (2006): p22—p32. http://dx.doi.org/10.1159/000097953.

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Krukemyer, Julie J., Harisios Boudoulas, Philip F. Binkley, and John J. Lima. "Biphasic pattern of hypersensitivity following acute propranolol withdrawal in normal subjects." Life Sciences 45, no. 17 (1989): 1547–51. http://dx.doi.org/10.1016/0024-3205(89)90420-7.

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Musso, Natale R., Renato Gianrossi, Aldo Pende, Claudio Vergassola, and Gaetano Lotti. "Plasma dopamine response to sympathetic activation in man: A biphasic pattern." Life Sciences 47, no. 7 (1990): 619–26. http://dx.doi.org/10.1016/0024-3205(90)90573-a.

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Nakao, Mitsuyuki, Hikaru Nishiyama, Dennis McGinty, Ronald Szymusiak, and Mitsuaki Yamamoto. "A model-based interpretation of the biphasic daily pattern of sleepiness." Biological Cybernetics 81, no. 5-6 (1999): 403–14. http://dx.doi.org/10.1007/s004220050571.

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Rowell, Janelle, Norimichi Koitabashi, David A. Kass, and Andreas S. Barth. "Dynamic gene expression patterns in animal models of early and late heart failure reveal biphasic-bidirectional transcriptional activation of signaling pathways." Physiological Genomics 46, no. 20 (2014): 779–87. http://dx.doi.org/10.1152/physiolgenomics.00054.2014.

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Altered cardiac gene expression in heart failure (HF) has mostly been identified by single-point analysis of end-stage disease. This may miss earlier changes in gene expression that are transient and/or directionally opposite to those observed later. Myocardial datasets from the largest microarray data repository (Gene Expression Omnibus) yielded six HF studies with time-course data. Differentially expressed transcripts between nonfailing controls, early HF (<3 days after cardiac insult) and late HF (usually >2 wk) were determined, and analysis of KEGG pathways and predicted regulatory c

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Shin, Hong In, K. H. Kim, Inn Kyu Kang, and Kyung Sik Oh. "Successful Osteoinduction by Cell-Macroporous Biphasic HA-TCP Ceramic Matrix." Key Engineering Materials 288-289 (June 2005): 245–48. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.245.

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To improve the potential of osteogenic repair, we developed macroporous biphasic hydroxyapatite-tricalcium phosphate (HA-TCP) ceramic and evaluated its efficiency as a scaffold for tissue engineered bone regeneration, which allows for appropriate cellular attachment and proliferation with osteogenic differentiation by evaluating ectopic bone formation ability after the implantation of cell-matrix construct in the skid mice subcutaneous pouches for 3 weeks. The macroporous biphasic HA-TCP ceramic matrix, with an average porosity of 86% and 200 µm mean pore size, provided favorable conditions fo

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Allaerts, Wilfried, Ans MI Tijssen, Pieter HM Jeucken, Hemmo A. Drexhage, and Jurrien de Koning. "Influence of folliculo-stellate cells on biphasic luteinizing hormone secretion response to gonadotropin-releasing hormone in rat pituitary cell aggregates." European Journal of Endocrinology 130, no. 5 (1994): 530–39. http://dx.doi.org/10.1530/eje.0.1300530.

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Allaerts W, Tijssen AMI, Jeucken PHM, Drexhage HA, de Koning J. Influence of folliculo-stellate cells on biphasic luteinizing hormone secretion response to gonadotropin-releasing hormone in rat pituitary cell aggregates. Eur J Endocrinol 1994;130:530–9. ISSN 0804–4643 Anterior pituitary cells cultured as three-dimensional cell aggregates and incubated with gonadotropin-releasing hormone (GnRH) show a biphasic pattern of luteinizing hormone (LH) release when steroid-free bovine follicle fluid is added to the culture medium. Initially, the GnRH-induced LH release is low (lag-phase response), but

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Dorfman, R., and B. Z. Shilo. "Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region." Development 128, no. 6 (2001): 965–72. http://dx.doi.org/10.1242/dev.128.6.965.

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The BMP pathway patterns the dorsal region of the Drosophila embryo. Using an antibody recognizing phosphorylated Mad (pMad), we followed signaling directly. In wild-type embryos, a biphasic activation pattern is observed. At the cellular blastoderm stage high pMad levels are detected only in the dorsal-most cell rows that give rise to amnioserosa. This accumulation of pMad requires the ligand Screw (Scw), the Short gastrulation (Sog) protein, and cleavage of their complex by Tolloid (Tld). When the inhibitory activity of Sog is removed, Mad phosphorylation is expanded. In spite of the uniform

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Magoski, Neil S., and Andrew G. M. Bulloch. "Dopamine Activates Two Different Receptors to Produce Variability in Sign at an Identified Synapse." Journal of Neurophysiology 81, no. 3 (1999): 1330–40. http://dx.doi.org/10.1152/jn.1999.81.3.1330.

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Dopamine activates two different receptors to produce variability in sign at an identified synapse. Chemical synaptic transmission was investigated at a central synapse between identified neurons in the freshwater snail, Lymnaea stagnalis. The presynaptic neuron was the dopaminergic cell, Right Pedal Dorsal one (RPeD1). The postsynaptic neuron was Visceral Dorsal four (VD4). These neurons are components of the respiratory central pattern generator. The synapse from RPeD1 to VD4 showed variability of sign, i.e., it was either inhibitory (monophasic and hyperpolarizing), biphasic (depolarizing f

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Reinhardt Piskackova, Theresa, S. Chris Reberg-Horton, Robert J. Richardson, Katie M. Jennings, and Ramon G. Leon. "Incorporating environmental factors to describe wild radish (Raphanus raphanistrum) seedling emergence and plant phenology." Weed Science 68, no. 6 (2020): 627–38. http://dx.doi.org/10.1017/wsc.2020.64.

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AbstractWild radish (Raphanus raphanistrum L.) is a weed found globally in agricultural systems. The facultative winter annual nature of this plant and high genetic variability makes modeling its growth and phenology difficult. In the present study, R. raphanistrum natural seedbanks exhibited a biphasic pattern of emergence, with emergence peaks occurring in both fall and spring. Traditional sigmoidal models were inadequate to fit this pattern, regardless of the predictive environmental variable, and a corresponding biphasic model (sigmoidal + Weibull) was used to describe emergence based on t

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Romanovsky, Andrej A., Christopher T. Simons, and Vladimir A. Kulchitsky. "“Biphasic” fevers often consist of more than two phases." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 1 (1998): R323—R331. http://dx.doi.org/10.1152/ajpregu.1998.275.1.r323.

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This paper disproves the common belief that all doses of lipopolysaccharide (LPS) that are commonly referred to as biphasic fever inducing (≥2 μg/kg) cause truly biphasic responses. A catheter was implanted into the right jugular vein of several strains of adult male rats, and the animals were habituated to the experimental conditions. At an ambient temperature of 30.0°C, loosely restrained animals were injected with a 10 μg/kg dose of LPS (various preparations), and their colonic (Tc) and tail skin temperatures were monitored (from ≥1 h before to ≥7 h after the injection). The results are pre

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Bonis, J. M., S. E. Neumueller, K. L. Krause, et al. "Site-specific effects on respiratory rhythm and pattern of ibotenic acid injections in the pontine respiratory group of goats." Journal of Applied Physiology 109, no. 1 (2010): 171–88. http://dx.doi.org/10.1152/japplphysiol.00934.2009.

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To probe further the contributions of the rostral pons to eupneic respiratory rhythm and pattern, we tested the hypothesis that ibotenic acid (IA) injections in the pontine respiratory group (PRG) would disrupt eupneic respiratory rhythm and pattern in a site- and state-specific manner. In 15 goats, cannulas were bilaterally implanted into the rostral pontine tegmental nuclei (RPTN; n = 3), the lateral (LPBN; n = 4) or medial parabrachial nuclei (MPBN; n = 4), or the Kölliker-Fuse nucleus (KFN; n = 4). After recovery from surgery, 1- and 10-μl injections (1 wk apart) of IA were made bilaterall

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van Dieten, J. A. M. J., J. de Koning, and G. P. van Rees. "Regulation by ovarian factors of the LHRH-induced LH response in pituitary glands in situ or grafted under the kidney capsule in intact and ovariectomized rats." Journal of Endocrinology 123, no. 1 (1989): 41–45. http://dx.doi.org/10.1677/joe.0.1230041.

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ABSTRACT When pituitary glands from intact female rats are incubated with LHRH, the resulting LH release shows a biphasic pattern: an initial low rate of LH release (lag phase) is followed by a high rate. When pituitary glands from long-term ovariectomized rats are incubated, the rate of LH release is high throughout stimulation with LHRH. The disappearance of the lag phase might be due to increased LHRH release after ovariectomy and/or the disappearance of ovarian factors. To distinguish between these possibilities, pituitary glands which had been exposed to endogenous LHRH (pituitary glands

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Petsche, Vicki M., Frederik J. Derksen, and N. Edward Robinson. "Tidal breathing flow-volume loops in horses with recurrent airway obstruction (heaves)." American Journal of Veterinary Research 55, no. 7 (1994): 885–91. http://dx.doi.org/10.2460/ajvr.1994.55.07.885.

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Summary Tidal breathing flow-volume (tbfv) loops were determined in a group of control horses and in horses affected with recurrent airway obstruction (heaves). The latter group was studied when the condition was in remission and under increasing amounts of airway obstruction as reflected by measurements of change in pleural pressure, pulmonary resistance, and dynamic compliance. The tbfv loops of control horses had biphasic inspiratory and expiratory patterns; peak inspiratory and peak expiratory flows were detected early in inspiration and expiration, respectively. Tidal volume was unaffecte

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Arisha, Mohammed J., Ahmad Hallak, and Ahmad Khan. "A Rare Presentation of a Rare Entity: Wellens Syndrome with Subtle Terminal T Wave Changes." Case Reports in Emergency Medicine 2019 (September 16, 2019): 1–4. http://dx.doi.org/10.1155/2019/1582030.

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Wellens syndrome is an electrocardiographic (ECG) pattern involving T waves in precordial leads that was first described in 1982 among a group of patients presenting with unstable angina suggestive of critical stenosis of the proximal left anterior descending (LAD) coronary. It is crucial for emergency physicians and internists to be able to recognize these patterns, as they occur in the symptom-free periods and represent a pre-infarction state that needs early intervention. Type A, which is characterized by biphasic T waves, mainly in V2 and V3, poses a significant challenge to recognize the

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Vicent, Lourdes, David González-Casal, Vanesa Bruña, et al. "Circadian Rhythm of Deaths in a Cardiology Department: A Five-Year Analysis." Cardiology 145, no. 6 (2020): 344–49. http://dx.doi.org/10.1159/000505682.

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Background: Previous studies have described a circadian pattern of death from cardiovascular causes with a morning peak. Our aim is to describe the daytime oscillations in mortality in hospitalized patients with cardiovascular diseases. Methods: Our retrospective registry including all patients who died in the Cardiology Department, including the cardiac intensive care unit, Madrid, Spain. Results: From a total of 500 patients, time of death was registered in 373 (74.6%), which are the focus of our study; 354 (70.8%) died in the cardiac intensive care unit and 146 (29.2%) in the conventional w

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Pradhan, Sunil, Rakesh K. Gupta, Mamta B. Singh, and Asha Mathur. "Biphasic illness pattern due to early relapse in Japanese-B virus encephalitis." Journal of the Neurological Sciences 183, no. 1 (2001): 13–18. http://dx.doi.org/10.1016/s0022-510x(00)00453-6.

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Igarashi, H., H. Shiraishi, H. Endoh, and M. Yanagisawa. "Biphasic flow velocity pattern in the descending aorta in double aortic arch." Pediatric Cardiology 16, no. 2 (1995): 87–89. http://dx.doi.org/10.1007/bf00796826.

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Liang, Rui, Peter Morris, Steven S. C. Cho, Helen E. Abud, Xianqing Jin, and Wei Cheng. "Hedgehog signaling displays a biphasic expression pattern during intestinal injury and repair." Journal of Pediatric Surgery 47, no. 12 (2012): 2251–63. http://dx.doi.org/10.1016/j.jpedsurg.2012.09.016.

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Rastinfard, Arghavan, Masoumeh Haghbin Nazarpak, and Fathollah Moztarzadeh. "Controlled chemical synthesis of CaO2 particles coated with polyethylene glycol: characterization of crystallite size and oxygen release kinetics." RSC Advances 8, no. 1 (2018): 91–101. http://dx.doi.org/10.1039/c7ra08758f.

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The oxygen release pattern of CaO<sub>2</sub> nanoparticles was biphasic: an initial burst phase for the first 24 hours followed by a descending release rate for three days. The oxygen release rate in the second phase mainly depended on the shrinking-core model for CaO<sub>2</sub> hydrolysis.

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Trimble, M. E. "Palmitate transport by rat renal basolateral membrane vesicles in the presence of albumin." Journal of the American Society of Nephrology 3, no. 12 (1993): 1920–29. http://dx.doi.org/10.1681/asn.v3121920.

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Long chain fatty acids are an important metabolic fuel for renal proximal tubules. Because of their insolubility, they are carried in the blood primarily bound to albumin. Processes involved in the cellular uptake of albumin-bound ligands are incompletely understood. To determine how fatty acids enter renal tubular cells when substrate was presented primarily bound to albumin (molar ratio albumin:palmitate = 1.0), [3H]palmitate uptake by basolateral membrane vesicles (BLMV) isolated from rat renal cortex was measured by a rapid filtration technique. The pattern of uptake was strikingly affecte

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