Log in

Relevant bibliographies by topics / Bipolar disorder, burden, course / Journal articles

To see the other types of publications on this topic, follow the link: Bipolar disorder, burden, course.

Journal articles on the topic 'Bipolar disorder, burden, course'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Bipolar disorder, burden, course.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Treuer, T., and M. Tohen. "Predicting the course and outcome of bipolar disorder: A review." European Psychiatry 25, no. 6 (October 2010): 328–33. http://dx.doi.org/10.1016/j.eurpsy.2009.11.012.

Full text

Abstract:

AbstractDespite of advances in pharmacological and non-pharmacological treatments, bipolar disorder often entails multiple relapses and impaired psychological functioning. The extent to which modern treatments have influenced the natural course of a mental disorder is uncertain. Prediction of the course and outcome of bipolar disorders continues to be challenging, despite the multiple research efforts worldwide. Due to a lack of laboratory diagnostic tests and biomarkers, psychiatric interview and examination provide the basis for outcome prediction. While considered to have more favorable prognosis than schizophrenia, it is not uncommon for bipolar disorder to include persisting alterations of psychosocial functioning. Although long-term symptomatic remission does not guarantee functional recovery, it may have a favorable impact on long-term overall prognosis. The high degree of treatment resistance in patients with bipolar disorder highlights the need to develop better identification of outcome predictors, prognosis and treatment intervention, designed to reverse or prevent this illness burden. This review summarizes the main factors involved in predicting the course and outcome of bipolar disorder.

APA, Harvard, Vancouver, ISO, and other styles

2

Wittchen, Hans-Ulrich, Stephan Mühlig, and Lukas Pezawas. "Natural course and burden of bipolar disorders." International Journal of Neuropsychopharmacology 6, no. 2 (June 2003): 145–54. http://dx.doi.org/10.1017/s146114570300333x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

McIntyre, Roger. "Bipolar Disorder and ADHD: Clinical Concerns." CNS Spectrums 14, S6 (July 2009): 8–9. http://dx.doi.org/10.1017/s1092852900024822.

Full text

Abstract:

During the past decade, a similar composite has emerged for both bipolar disorder and adult attention-deficit/hyperactive disorder (ADHD). First, both conditions have a relatively high prevalence, a low case detection, a protracted illness course, a high rate of comorbidity, multifactorial ideology, substantial heritable liability, and tremendous burden of illness in economic cost as well as interpersonal and vocational maladjustments. What has also been interesting along with these reports is that there has been emerging scientific studies implicating common brain regions and neural circuits subserving essential features of both conditions.

APA, Harvard, Vancouver, ISO, and other styles

4

Bermúdez-Ampudia, C., A. García-Alocén, M. Martínez-Cengotitabengoa, S. Alberich, I. González-Ortega, S. Barbeito Resa, and A. González-Pinto. "Mixed-effects models: Family burden and functionality in patients with bipolar disorder." European Psychiatry 33, S1 (March 2016): S331. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1147.

Full text

Abstract:

IntroductionThe bipolar disorder (BD) has an important effect over the lives of patients and families. The attitude of the family is a modifiable factor through specific interventions and it has been related with BD prognosis.ObjectivesStudy a sample of families and patients with BD.AimsCompare between two groups its course of burden of caring for family members with BD. Also, we will see the course of the functionality in patients.MethodsSample of 148 individuals who caring a familiar with BD. Seventy-six of these followed psychoeducation session are going to be experimental group (EG), and the others 72 did not followed any session are going to be control group (CG). There is a follow-up at 6 months and one year. To see the course of the burden and the functionality it will be used mixed models.ResultsAt baseline, there were not significant differences between CG and EG in objective and subjective burden and functionality. But over time there were significant results in the three cases. For objective burden (b = −0.016; P = 0.0001) EG presented a drop (b = −0.014; P = 0.0062), while CG did not show changes (b = 0.002; P = 0.4691). For subjective burden (b = −0.014; P = 0.0058) without significant results for CG (b = −0.352; P = 0.3203) and a significant decrease in EG (b = −0.017; P = 0.003). For the functionality (b = 1.474; P = 0.000) there was a significant increase in EG (b = 1.349; P = 0.000) but not for CG (b = −0.125; P = 0.3828).ConclusionsTwo groups did not differ at baseline however after the psychoeducation sessions appear clear differences, decreasing the burden for EG group and the functionality also improved for EG.Disclosure of interestThe authors have not supplied their declaration of competing interest.

APA, Harvard, Vancouver, ISO, and other styles

5

Forty, Liz, Anna Ulanova, Lisa Jones, Ian Jones, Katherine Gordon-Smith, Christine Fraser, Anne Farmer, et al. "Comorbid medical illness in bipolar disorder." British Journal of Psychiatry 205, no. 6 (December 2014): 465–72. http://dx.doi.org/10.1192/bjp.bp.114.152249.

Full text

Abstract:

BackgroundIndividuals with a mental health disorder appear to be at increased risk of medical illness.AimsTo examine rates of medical illnesses in patients with bipolar disorder (n = 1720) and to examine the clinical course of the bipolar illness according to lifetime medical illness burden.MethodParticipants recruited within the UK were asked about the lifetime occurrence of 20 medical illnesses, interviewed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and diagnosed according to DSM-IV criteria.ResultsWe found significantly increased rates of several medical illnesses in our bipolar sample. A high medical illness burden was associated with a history of anxiety disorder, rapid cycling mood episodes, suicide attempts and mood episodes with a typically acute onset.ConclusionsBipolar disorder is associated with high rates of medical illness. This comorbidity needs to be taken into account by services in order to improve outcomes for patients with bipolar disorder and also in research investigating the aetiology of affective disorder where shared biological pathways may play a role.Declarations of interestNone.

APA, Harvard, Vancouver, ISO, and other styles

6

Coryell, W., J. Fiedorowicz, D. Solomon, and J. Endicott. "Age transitions in the course of bipolar I disorder." Psychological Medicine 39, no. 8 (April 1, 2009): 1247–52. http://dx.doi.org/10.1017/s0033291709005534.

Full text

Abstract:

BackgroundThis analysis aimed to show whether symptoms of either pole change in their persistence as individuals move through two decades, whether such changes differ by age grouping, and whether age of onset plays an independent role in symptom persistence.MethodParticipants in the National Institute of Mental Health (NIMH) Collaborative Depression Study (CDS) who completed at least 20 years of follow-up and who met study criteria for bipolar I or schizo-affective manic disorder, before intake or during follow-up, were divided by age at intake into youngest (18–29 years, n=56), middle (30–44 years, n=68) and oldest (>44 years, n=24) groups.ResultsThe persistence of depressive symptoms increased significantly in the two younger groups. Earlier ages of onset were associated with higher depressive morbidity throughout the 20 years of follow-up but did not predict changes in symptom persistence. The proportions of weeks spent in episodes of either pole correlated across follow-up periods in all age groupings, although correlations were stronger for depressive symptoms and for shorter intervals.ConclusionsRegardless of age at onset, the passage of decades in bipolar illness seems to bring an increase in the predominance of depressive symptoms in individuals in their third, fourth and fifth decades and an earlier age of onset portends a persistently greater depressive symptom burden. The degree to which either depression or manic/hypomanic symptoms persist has significant stability over lengthy periods and seems to reflect traits that manifest early in an individual's illness.

APA, Harvard, Vancouver, ISO, and other styles

7

Rakofsky, Jeffrey J., Steven T. Levy, and Boadie W. Dunlop. "Conceptualizing Treatment Nonadherence in Patients with Bipolar Disorder and PTSD." CNS Spectrums 16, no. 1 (January 2011): 11–20. http://dx.doi.org/10.1017/s1092852912000119.

Full text

Abstract:

AbstractTreatment nonadherence is a concern among patients with bipolar disorder and posttraumatic stress disorder (PTSD). PTSD is common among patients with bipolar disorder and those with this comorbidity often have a more severe course of illness. While many factors have been associated with nonadherence in bipolar disorder patients and in PTSD patients, almost no research has focused on the factors associated with non-adherence in bipolar disorder patients with comorbid PTSD. Studies in primary bipolar disorder samples reveal patient, illness, drug and clinician characteristics associated with nonadherence while studies in primary PTSD samples reveal a significantly shorter list of patient, illness and drug characteristics. Shared risk factors between these two populations and the characteristics that predict noncompliance in only one population but often present in the other, suggest a high likelihood of nonadherence in the bipolar disorder-PTSD population. For bipolar disorder-PTSD patients with early childhood trauma, noncompliance may be related to the trauma-related meanings attributed to interactions with their physicians and their prescribed medications. Given the high side effect burden of bipolar disorder treatments and the importance of lifelong adherence, clinicians should vigilantly monitor for nonadherence in their bipolar disorder-PTSD patients and be particularly aware of patient-physician psychodynamics that might contribute to this behavior.

APA, Harvard, Vancouver, ISO, and other styles

8

GOIKOLEA, J. M., F. COLOM, A. MARTÍNEZ-ARÁN, J. SÁNCHEZ-MORENO, A. GIORDANO, A. BULBENA, and E. VIETA. "Clinical and prognostic implications of seasonal pattern in bipolar disorder: a 10-year follow-up of 302 patients." Psychological Medicine 37, no. 11 (May 31, 2007): 1595–99. http://dx.doi.org/10.1017/s0033291707000864.

Full text

Abstract:

ABSTRACTBackgroundMore than 20% of bipolar patients may present with seasonal pattern (SP). Seasonality can alter the course of bipolar disorder. However, to date, long-term follow-up studies of bipolar patients presenting with SP are scarce. We present a 10-year follow-up study comparing clinical and demographic features of bipolar patients with and without SP.MethodThree hundred and twenty-five bipolar I and II patients were followed up for at least 10 years. SP was defined according to DSM-IV criteria. Clinical variables were obtained from structured interviews with the patients and their relatives. Patients with and without SP were compared regarding clinical and sociodemographic variables and a stepwise logistic regression was performed.ResultsSeventy-seven patients (25·5%) were classified as presenting with SP, while 225 (74·5%) were considered as presenting with no significant seasonal variation. Twenty-three patients (7%) were excluded from the study because it was unclear whether they had seasonality or not. There were no differences between groups regarding demographic variables. Patients with SP predominantly presented with bipolar II disorder, depressive onset, and depressive predominant polarity. The greater burden of depression did not correlate with indirect indicators of severity, such as suicidality, hospitalizations or psychotic symptoms.ConclusionsOur study links the presence of SP with both bipolar II disorder and predominant depressive component. However, we could not find any difference regarding functionality or hospitalization rates. Modifications in the criteria to define SP are suggested for a better understanding of bipolar disorder.

APA, Harvard, Vancouver, ISO, and other styles

9

Muralidharan, Kesavan, Ivan J. Torres, Leonardo E. Silveira, Jan-Marie Kozicky, Joana Bücker, Nadeesha Fernando, and Lakshmi N. Yatham. "Impact of depressive episodes on cognitive deficits in early bipolar disorder: data from the Systematic Treatment Optimization Programme for Early Mania (STOP-EM)." British Journal of Psychiatry 205, no. 1 (July 2014): 36–43. http://dx.doi.org/10.1192/bjp.bp.113.135525.

Full text

Abstract:

BackgroundAlthough manic episodes reportedly contribute to cognitive deficits in bipolar I disorder, the contribution of depressive episodes is poorly researched.AimsWe investigated the impact of depressive episodes on cognitive function early in the course of bipolar I disorder.MethodA total of 68 patients and 38 controls from the Systematic Treatment Optimization Programme for Early Mania (STOP-EM) first-episode mania programme were examined. We conducted (a) a cross-sectional analysis of the impact of prior depressive episodes on baseline cognitive function and (b) a prospective analysis assessing the contribution of depression recurrence within 1 year following a first episode of mania on cognitive functioning.ResultsThe cross-sectional analysis showed no significant differences between patients with past depressive episodes compared with those without, on overall or individual domains of cognitive function (allP>0.09). The prospective analysis failed to reveal a significant group×time interaction for cognitive decline from baseline to 1 year (P= 0.99) in patients with a recurrence of depressive episodes compared with those with no recurrence. However, impaired verbal memory at baseline was associated with a depression recurrence within 1 year.ConclusionsAlthough deficits in all domains of cognitive function are seen in patients early in the course of bipolar disorder, depressive episodes do not confer additional burden on cognitive function. However, poorer verbal memory may serve as a marker for increased susceptibility to depression recurrence early in the course of illness.

APA, Harvard, Vancouver, ISO, and other styles

10

Bilska, Karolina, Joanna Pawlak, Paweł Kapelski, Beata Narożna, Przemysław Zakowicz, Aleksandra Szczepankiewicz, Maria Skibińska, and Monika Dmitrzak-Węglarz. "Differences in the Clinical Picture in Women with a Depressive Episode in the Course of Unipolar and Bipolar Disorder." Journal of Clinical Medicine 10, no. 4 (February 10, 2021): 676. http://dx.doi.org/10.3390/jcm10040676.

Full text

Abstract:

Due to current depression prevalence, it is crucial to make the correct diagnosis as soon as possible. The study aimed to identify commonly available, easy to apply, and quick to interpret tools allowing for a differential diagnosis between unipolar and bipolar disorder. The study group includes women with long duration of unipolar (UP, N = 34) and bipolar (BP, N = 43) affective disorder. The diagnosis was established according to the DSM criteria using SCID questionnaire. Additional questionnaires were used to differentiate between UP and BP. BP patients had an earlier age of onset, were hospitalized more times, and more often had a family history of psychiatric disorders than UP (p-value < 0.05). Moreover, BP achieved a higher impulsiveness score and more frequently had experienced severe problems with close individuals. To our knowledge, this is the first publication presenting results of numerous questionnaires applied simultaneously in patients on clinical group. Several of them suggest the direction of clinical assessment, such as: the age of onset, family psychiatric burdens, history of stressful life events, learning problems, social and job relations. Further studies are necessary to confirm the utility of this approach.

APA, Harvard, Vancouver, ISO, and other styles

11

Karpov, B., G. Joffe, K. Aaltonen, J. Suvisaari, I. Baryshnikov, P. Näätänen, M. Koivisto, et al. "Level of functioning, perceived work ability, and work status among psychiatric patients with major mental disorders." European Psychiatry 44 (July 2017): 83–89. http://dx.doi.org/10.1016/j.eurpsy.2017.03.010.

Full text

Abstract:

AbstractBackground:Major mental disorders are highly disabling conditions that result in substantial socioeconomic burden. Subjective and objective measures of functioning or ability to work, their concordance, or risk factors for them may differ between disorders.Methods:Self-reported level of functioning, perceived work ability, and current work status were evaluated among psychiatric care patients with schizophrenia or schizoaffective disorder (SSA, n = 113), bipolar disorder (BD, n = 99), or depressive disorder (DD, n = 188) within the Helsinki University Psychiatric Consortium Study. Correlates of functional impairment, subjective work disability, and occupational status were investigated using regression analysis.Results:DD patients reported the highest and SSA patients the lowest perceived functional impairment. Depressive symptoms in all diagnostic groups and anxiety in SSA and BD groups were significantly associated with disability. Only 5.3% of SSA patients versus 29.3% or 33.0% of BD or DD patients, respectively, were currently working. About half of all patients reported subjective work disability. Objective work status and perceived disability correlated strongly among BD and DD patients, but not among SSA patients. Work status was associated with number of hospitalizations, and perceived work disability with current depressive symptoms.Conclusions:Psychiatric care patients commonly end up outside the labour force. However, while among patients with mood disorders objective and subjective indicators of ability to work are largely concordant, among those with schizophrenia or schizoaffective disorder they are commonly contradictory. Among all groups, perceived functional impairment and work disability are coloured by current depressive symptoms, but objective work status reflects illness course, particularly preceding psychiatric hospitalizations.

APA, Harvard, Vancouver, ISO, and other styles

12

Baldwin, D. "Manifesto for a European anxiety disorders research network." European Psychiatry 26, S2 (March 2011): 2094. http://dx.doi.org/10.1016/s0924-9338(11)73797-x.

Full text

Abstract:

Anxiety disorders are common, have an early onset, run a long course, cause substantial distress, impair overall function, reduce quality of life and impose a major economic burden, and therefore represent an important public health problem. Many patients do not present or are not recognized, the standard of care is often sub-optimal, and the effectiveness of interventions in real-world practice can be disappointing: there is considerable room for improvement in recognition, care and treatment.The causes remain largely unknown and this hinders accurate diagnosis, prediction of prognosis, and development of refined treatment approaches. There is much co-morbidity between the disorders and with conditions such as bipolar disorder, depressive illness and physical illness. Research findings in patient samples without co-morbidity may have limited applicability to wider practice, and there is a need to undertake research in fully representative groups. Little is known about determinants of non-response, or next steps in management after the failure of first-line interventions, and there is a clear need for research in the substantial proportion with ‘treatment-resistant’ conditions.The unmet public health, clinical and research needs could therefore be addressed by developing an independent collaborative European Anxiety Disorders Research Network. This would facilitate harmonization of research and clinical databases and refinement of research methodologies. It should contribute to greater accuracy when predicting clinical outcome, and encourage the evaluation of innovative interventions, particularly in important groups such as in the early stages of illness, those with comorbid disorders, and those who have not responded to initial treatment approaches.

APA, Harvard, Vancouver, ISO, and other styles

13

Ramadan, Abdullah Mohammed, and Islam Ahmed Mansour. "Could ketamine be the answer to treating treatment-resistant major depressive disorder?" General Psychiatry 33, no. 5 (August 2020): e100227. http://dx.doi.org/10.1136/gpsych-2020-100227.

Full text

Abstract:

Major depressive disorder (MDD) is a common, serious, debilitating condition affecting 350 million people worldwide, which remains to be unsatisfactorily treated with 53% of patients still complaining of symptoms after completing their courses with the correct dosage. Ketamine, which was approved by the Food and Drug Administration in 2019, is a potential treatment option for those recalcitrant cases. The mechanism of ketamine is not fully understood, but as type it is classified as an N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, and can be given intravenously, intranasally and orally. It is used to treat treatment-resistant depression, depression associated with suicidal ideation, mood and anxiety disorders and depressions associated with either type of bipolar disorder. Although ketamine is considered relatively safe, several side effects have been reported with the major ones being psychiatric in the form of worsening mood, anxiety and agitation; psychotomimetic in the form of dissociation, perceptual disturbance and abnormal sensations; cardiovascular in the form of increased blood pressure and increased heart rate; and neurological in the form of headache and dizziness. Ketamine is still not approved worldwide for usage in patients with treatment-resistant MDD, but if it is approved sometime in the future with relatively fewer side effects, it is expected to significantly save millions of dollars spent yearly on patients with treatment-resistant depression and that will lift this major burden off the shoulders of healthcare professionals. This study was designed to measure the effects of ketamine, an NMDA receptor antagonist, on patients with treatment-resistant MDD and to analyse the concept that makes it different and relatively safer than other major antidepressants like selective serotonin reuptake inhibitors, monoamine oxidase inhibitors and TCAs (tricyclic antidepressants).

APA, Harvard, Vancouver, ISO, and other styles

14

Alonso, Pino, Brian Price, Abdul R. Conteh, Carmen Valle, Patrick E. Turay, Lourdes Paton, and Joseph A. Turay. "Where there is no psychiatrist: A mental health programme in Sierra Leone." South African Journal of Psychiatry 20, no. 3 (August 30, 2014): 6. http://dx.doi.org/10.4102/sajpsychiatry.v20i3.498.

Full text

Abstract:

<p><strong>Background.</strong> For most low- and middle-income countries, mental health remains a neglected area, despite the recognised burden associated with neuropsychiatric conditions and the inextricable link to other public health priorities.</p><p><strong>Objectives.</strong> To describe the results of a free outpatient mental health programme delivered by non-specialist health workers in Makeni, Sierra Leone between July 2008 and May 2012. </p><p><strong>Methods.</strong> A nurse and two counsellors completed an 8-week training course focused on the identification and management of seven priority conditions: psychosis, bipolar disorder, depression, mental disorders due to medical conditions, developmental and behavioural disorders, alcohol and drug use disorders, and dementia. The World Health Organization recommendations on basic mental healthcare packages were followed to establish treatment for each condition. </p><p><strong>Results.</strong> A total of 549 patients was assessed and diagnosed as suffering from psychotic disorders (<em>n</em>=295, 53.7%), manic episodes (<em>n</em>=69, 12.5%), depressive episodes (<em>n</em>=53, 9.6%), drug use disorders (<em>n</em>=182, 33.1%), dementia (<em>n</em>=30, 5.4%), mental disorders due to medical conditions (<em>n</em>=39, 7.1%), and developmental disorders (<em>n</em>=46, 8.3%). Of these, 417 patients received pharmacological therapy and 70.7% were rated as much or very much improved. Of those who could not be offered medication, 93.4% dropped out of the programme after the first visit. </p><p><strong>Conclusions.</strong> The identification and treatment of mental disorders must be considered an urgent public health priority in low- and middle-income countries. Trained primary health workers can deliver safe and effective treatment for mental disorders as a feasible alternative to ease the scarcity of mental health specialists in developing countries.</p>

APA, Harvard, Vancouver, ISO, and other styles

15

Saunders, Kate E. A., and Guy M. Goodwin. "The course of bipolar disorder." Advances in Psychiatric Treatment 16, no. 5 (September 2010): 318–28. http://dx.doi.org/10.1192/apt.bp.107.004903.

Full text

Abstract:

SummaryBipolar disorder is arguably a pivotal diagnosis in adult psychiatry bounded by schizophrenia on one side and unipolar depression on the other. It represents a wide spectrum of disorders, all sharing common features of elated and depressed mood. The early descriptions of symptom-free euthymia have long been dismissed and the chronic and enduring deficits associated with the disorder are beginning to be better understood. We review the current literature with regard to the course of the disorder, factors that may influence prognosis and common comorbidities.

APA, Harvard, Vancouver, ISO, and other styles

16

Kotzian, Bruno, Ives Cavalcante Passos, and Flávio Kapczinski. "Longitudinal course of bipolar disorder." Revista Debates em Psiquiatria Ano 6 (October 1, 2016): 6–8. http://dx.doi.org/10.25118/2236-918x-6-5-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Barcellini, Wilma, Elisa Scola, Silvia Lanfranconi, Marika Grottaroli, Francesca Binda, Bruno Fattizzo, Anna Zaninoni, et al. "Brain MRI Findings and Neuro-Psychiatric Involvement in Paroxysmal Nocturnal Hemoglobinuria (PNH)." Blood 128, no. 22 (December 2, 2016): 4800. http://dx.doi.org/10.1182/blood.v128.22.4800.4800.

Full text

Abstract:

Abstract PNH is a rare disorder characterized by hemolytic anemia, marrow failure and thrombosis, due to a deficiency in GPI-anchored proteins. Thrombotic events in PNH are commonly described in hepatic, portal, mesenteric, splenic, and renal veins, along with anecdotic case reports of cerebral venous sinus thrombosis and arterial ischemic strokes. This study was aimed at investigate brain involvement in 19 asymptomatic PNH patients by non-enhanced cerebral magnetic resonance imaging (MRI), and by intracranial arterial and venous angio-MRI. Neuroradiological findings were completed with a neuro-psychiatric evaluation, and correlated with clinical/hematologic features and therapy. Seventeen out of 19 patients were classical hemolytic (63% transfusion dependent before treatment with eculizumab and 1 patient also after), and 2 PNH in the context of aplastic anemia (all transfusion-dependent until treatment with ATG-CyA). Median age at diagnosis was 44 years (range 17-80); asthenia and dyspnea on exertion were present in all patients, abdominal pain in 8, and a thrombotic event in 4. Median Hb was 9.6 g/dL (range 6.7-12.9), LDH 3.7-fold (range 1.2-16.3) over upper limit of normal (ULN), and 73% of patients displayed a clone size greater than 50% GPI negative cells; 10/19 of patients were on eculizumab at the moment of the study. On MRI, 11 subjects showed pathological findings: 9 cases displayed white matter (WM) abnormalities related to chronic ischemic small vessel disease, of whom 6 periventricular WM vascular degeneration, and 8 deep WM focal chronic ischemic lesions (5 cases have both sites involved). Moreover, 1 subject showed a focal abnormality >5 mm and 5 subjects a score > 4 as evaluated in WM and basal ganglia by the age related white matter changes (ARWMC) scale. No subject displayed active or previous bleeding, nor were focal alterations of the basal nuclei by the ARWMC scale found. Two patients (80 and 81 yrs) showed atrophy of the cerebral hemispheres. Regarding vascular abnormalities, one subject had hypoplastic left transverse sinus with irregularities in the sinus wall, suspected for prior partial venous thrombosis. Three further cases displayed hypoplastic transverse sinus associated with collateral draining cortical veins, indistinguishable from anatomical variants. Intracranial artery stenosis or aneurysm, and Moya-Moya like alterations were not observed. Finally, cerebral MRI was unremarkable in 8/19 subjects. By comparing patients with or without any MRI abnormality (WM and vascular alterations), mean age was significantly higher in the former (60+17 vs 43+8 yrs, mean+SD, p<0.05), whereas blood counts, hemolytic markers and clone size showed no remarkable differences. Hemoglobin at diagnosis was slightly lower (9.5+1.5 vs 9.9+1.6 g/dL, mean+SD), and LDH greater (5.8+4.4 vs 4.1+2.9 over ULN, mean+SD) in subjects who displayed MRI abnormalities. Moreover, individual hemoglobin levels negatively correlated with the ARWMC score (r=-0.45, p<0.05). No relationship was found between history of abdominal pain/thrombosis and MRI pathological findings. Likewise, MRI abnormalities were not correlated with disease duration. As regards therapy with eculizumab, a pathological MRI was found in 6/10 subjects under treatment and in 5/9 without; the sole significant vascular alteration was detected in a patient under treatment. Neurological examination was unremarkable in all patients but one, who complained of progressive rest tremor in his left arm and leg (twelve years after PNH diagnosis), and was diagnosed with possible Parkinson disease. Previous history of neurological disorders was observed in 3 patients: one typical transient global amnesia (at the age of 60), one seizures (at 5 years), and one headache before the diagnosis of PNH. Regarding psychiatric evaluation, 3/18 patients had a psychiatric disorder according to structured clinical interview for axis I DSM-IV-TR disorders (1 generalized anxiety disorder, 1 bipolar disorder type 2, and 1 adjustment disorder as a consequence of PNH diagnosis). No relationship was observed between MRI findings and neuro-psychiatric assessment. In conclusion, brain MRI revealed chronic ischemic and vascular lesions in 58% of asymptomatic PNH patients. Brain MRI is advisable at diagnosis and during the course of the disease, and WM lesion burden may be useful in the decision to start therapy. Disclosures Barcellini: Agios: Consultancy.

APA, Harvard, Vancouver, ISO, and other styles

18

Goodwin, G. "Bipolar disorder." European Psychiatry 26, S2 (March 2011): 2184. http://dx.doi.org/10.1016/s0924-9338(11)73887-1.

Full text

Abstract:

Bipolar disorder is rapidly becoming the primary diagnosis in adult psychiatry. It represents a wide spectrum of disorder all sharing common features of elated and depressed mood. The early descriptions of symptom-free euthymia have long been dismissed and the chronic and enduring deficits associated with the disorder are beginning to be better understood. The course of the disorder remains uncertain especially in light of the recently observed increases in children receiving the diagnosis. There is growing interest in the elated states seen as a common adolescent phenotype.There is a simplified view of the illness as an episodic course interspersed with euthymia, short-term treatments being used in acute episodes and long-term treatments being indefinite and intended to prevent new episodes. However, subsyndromes, co-morbidities and a variety of chronic symptoms are common in bipolar disorder. In practice, they often drive treatment decisions. Chronic symptoms are usually related to anxiety, depression or cognition and are a disabling aspect of the long-term outcome. Unfortunately, there is little to guide the selection of treatment to reduce the impact of these symptoms since they have almost never been the subject of clinical trials.The use of medication in combinations is the usual practice in bipolar disorder. The argument to favour this in guidelines is highly pragmatic, but there is a growing evidence base to support it. Lithium remains a key benchmark treatment for comparing alternatives in long term efficacy. Its effects against suicide are particularly important.

APA, Harvard, Vancouver, ISO, and other styles

19

Maleki, Nayereh, Effat Sadeghian, Farshid Shamsaei, Lily Tapak, and Ali Ghaleiha. "Comparative Analysis of Spouse’s Burden and Quality of Life in Major Depressive Disorder and Bipolar I Disorder." Current Psychiatry Research and Reviews 15, no. 3 (October 19, 2019): 193–98. http://dx.doi.org/10.2174/1874464812666190819151039.

Full text

Abstract:

Background: Spouses of patients with bipolar disorder may experience a different quality of life and burden than seen with major depressive disorder. Objective: This study was conducted to comparatively analyse spouse’s burden and quality of life in major depressive and bipolar disorders. Methods: This cross-sectional study was conducted on 220 spouses of patients with major depressive and bipolar disorders in the city of Hamadan in Iran, in 2018. Data collection tools included Zarit Burden and QOL-BREF questionnaires. Data were analyzed by a t-test using SPSS -16. Results: The findings showed that 11.8% of spouses of patients with depression and 85.5% of spouses of patients with bipolar disorder experienced severe burden (P < 0.001). The quality of life of spouses of patients with bipolar disorder was lower than with depressive disorder (P < 0.05). In both the groups, a negative correlation was found between burden and QOL. Conclusion: The spouses of patients with bipolar disorder experience more burden and lower quality of life than depression. In both the groups, burden has a negative impact on the quality of life. Professional help and supportive intervention can be provided to the spouses of patients with major depressive and bipolar I disorders to reduce their burden, strengthen their coping skill and thus improve their QOL.

APA, Harvard, Vancouver, ISO, and other styles

20

Kupfer, David J. "The Increasing Medical Burden in Bipolar Disorder." JAMA 293, no. 20 (May 25, 2005): 2528. http://dx.doi.org/10.1001/jama.293.20.2528.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Perlick, Deborah A., Robert A. Rosenheck, David J. Miklowitz, Richard Kaczynski, Bruce Link, Terence Ketter, Stephen Wisniewski, Nancy Wolff, and Gary Sachs. "Caregiver Burden and Health in Bipolar Disorder." Journal of Nervous and Mental Disease 196, no. 6 (June 2008): 484–91. http://dx.doi.org/10.1097/nmd.0b013e3181773927.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Angst, J., F. Angst, R. Sellaro, and H. Zhang. "S27.01 Longterm course of bipolar disorder." European Psychiatry 15, S2 (October 2000): 267s. http://dx.doi.org/10.1016/s0924-9338(00)94155-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Birmaher, Boris. "Longitudinal Course of Pediatric Bipolar Disorder." American Journal of Psychiatry 164, no. 4 (April 2007): 537–39. http://dx.doi.org/10.1176/ajp.2007.164.4.537.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Solomon, David A., Andrew C. Leon, William H. Coryell, Jean Endicott, Chunshan Li, Jess G. Fiedorowicz, Lara Boyken, and Martin B. Keller. "Longitudinal Course of Bipolar I Disorder." Archives of General Psychiatry 67, no. 4 (April 1, 2010): 339. http://dx.doi.org/10.1001/archgenpsychiatry.2010.15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Miller, Ivan W., Lisa A. Uebelacker, Gabor I. Keitner, Christine E. Ryan, and David A. Solomon. "Longitudinal course of bipolar I disorder." Comprehensive Psychiatry 45, no. 6 (November 2004): 431–40. http://dx.doi.org/10.1016/j.comppsych.2004.07.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Titmarsh, Steve. "The burden of bipolar disorder in the UK." Progress in Neurology and Psychiatry 16, no. 5 (September 2012): 25–26. http://dx.doi.org/10.1002/pnp.250.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Fagiolini, Andrea, Rocco Forgione, Mauro Maccari, Alessandro Cuomo, Benedetto Morana, Mario Catena Dell'Osso, Francesca Pellegrini, and Alessandro Rossi. "Prevalence, chronicity, burden and borders of bipolar disorder." Journal of Affective Disorders 148, no. 2-3 (June 2013): 161–69. http://dx.doi.org/10.1016/j.jad.2013.02.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Biederman, J., and E. Mick. "Longitudinal course of pediatric-onset bipolar disorder." European Neuropsychopharmacology 12 (October 2002): 221. http://dx.doi.org/10.1016/s0924-977x(02)80253-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Strakowski, Stephen M., David E. Fleck, Melissa P. DelBello, Caleb M. Adler, Paula K. Shear, Renu Kotwal, and Stephan Arndt. "Impulsivity across the course of bipolar disorder." Bipolar Disorders 12, no. 3 (May 2010): 285–97. http://dx.doi.org/10.1111/j.1399-5618.2010.00806.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Almeida, Osvaldo P. "Does bipolar disorder have a benign course?" International Psychogeriatrics 28, no. 11 (September 16, 2016): 1755–57. http://dx.doi.org/10.1017/s1041610216001423.

Full text

Abstract:

Written records have been describing extreme states of emotions since ancient Greece (Angst and Marneros, 2001), but Aretaeus of Cappadocia (which is geographically located in modern Turkey) was probably the first to outline the close relationship between depression and mania nearly 2000 years ago: “I think that melancholia is the beginning and a part of mania. . . The development of mania is really a worsening of the disease rather than a change into another disease. . . In most of them the sadness became better after various lengths of time and changed into happiness; the patients then developed a mania” (Angst and Marneros, 2001). Limited progress in our understanding of these extreme states of affect occurred until the mid-1800s, when both German and French physicians suggested that the change from melancholia to mania was not only “usual,” but that the continuous cycle between depression, mania, and disease free intervals were the key features of a mental disorder. Jean Pierre Falret named the disorder “folie circulaire” (1851), while Jules Baillarger called it “folie a double-form” (1854).

APA, Harvard, Vancouver, ISO, and other styles

31

Khanna, R., N. Gupta, and S. Shanker. "Course of bipolar disorder in eastern India." Journal of Affective Disorders 24, no. 1 (January 1992): 35–41. http://dx.doi.org/10.1016/0165-0327(92)90058-e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Gilbert, Kirsten E., Jessica H. Kalmar, Fay Y. Womer, Philip J. Markovich, Brian Pittman, Susan Nolen-Hoeksema, and Hilary P. Blumberg. "Impulsivity in adolescent bipolar disorder." Acta Neuropsychiatrica 23, no. 2 (April 2011): 57–61. http://dx.doi.org/10.1111/j.1601-5215.2011.00522.x.

Full text

Abstract:

Objective: Increased impulsivity has been shown to be a trait feature of adults with bipolar disorder (BD), yet impulsivity has received little study in adolescents with BD. Thus, it is unknown whether it is a trait feature that is present early in the course of the disorder. We tested the hypotheses that self-reported impulsiveness is increased in adolescents with BD, and that it is present during euthymia, supporting impulsiveness as an early trait feature of the disorder.Methods: Impulsiveness was assessed in 23 adolescents with BD and 23 healthy comparison (HC) adolescents using the self-report measure of impulsivity, the Barratt Impulsiveness Scale (BIS), comprised by attentional, motor and non-planning subscale scores. Effects of subscale scores and associations of scores with mood state and course features were explored.Results: Total and subscale BIS scores were significantly higher in adolescents with BD than HC adolescents. Total, attentional and motor subscale BIS scores were also significantly higher in the subset of adolescents with BD who were euthymic, compared to HC adolescents. Adolescents with BD with rapid-cycling and chronic mood symptoms had significantly higher total and motor subscale BIS scores than adolescents with BD without these course features.Conclusion: These results suggest increased self-reported impulsiveness is a trait feature of adolescents with BD. Elevated impulsivity may be especially prominent in adolescents with rapid-cycling and chronic symptoms.

APA, Harvard, Vancouver, ISO, and other styles

33

Frank, E. "C.19.02 The increasing medical burden in bipolar disorder." European Neuropsychopharmacology 16 (January 2006): S590. http://dx.doi.org/10.1016/s0924-977x(06)70869-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Vieta, Eduard, Maria Luisa Figueira, Frank Bellivier, Daniel Souery, Elena Blasco-Colmenares, Esteban Medina, and Jens M. Langosch. "Clinical and healthcare burden in patients with bipolar disorder." International Clinical Psychopharmacology 26 (September 2011): e44. http://dx.doi.org/10.1097/01.yic.0000405705.91360.6d.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Casalini, F., S. Belletti, N. Mosti, V. Mastria, S. Rizzato, G. Ceraudo, L. Dell’Osso, and G. Perugi. "Burden of metabolic diseases in patients with bipolar disorder." International Clinical Psychopharmacology 28 (December 2012): e61-e62. http://dx.doi.org/10.1097/01.yic.0000423353.38579.1d.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Birnbaum, HG, E. Dial, EF Oster, PE Greenberg, and L. Shi. "PMH29: ECONOMIC BURDEN OF NOT RECOGNIZING BIPOLAR DISORDER PATIENTS." Value in Health 6, no. 3 (May 2003): 353. http://dx.doi.org/10.1016/s1098-3015(10)64231-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Stimmel, Glen L. "Economic Grand Rounds: The Economic Burden of Bipolar Disorder." Psychiatric Services 55, no. 2 (February 2004): 117–18. http://dx.doi.org/10.1176/appi.ps.55.2.117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Dols, Annemiek, Carisha Thesing, Martijn Wouters, Jan Theunissen, Caroline Sonnenberg, Hannie Comijs, and Max L. Stek. "Burden on caregivers of older patients with bipolar disorder." Aging & Mental Health 22, no. 5 (March 9, 2017): 686–91. http://dx.doi.org/10.1080/13607863.2017.1297360.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Axelson, David A., Boris Birmaher, Michael A. Strober, Benjamin I. Goldstein, Wonho Ha, Mary Kay Gill, Tina R. Goldstein, et al. "Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression From Bipolar Disorder Not Otherwise Specified." Journal of the American Academy of Child & Adolescent Psychiatry 50, no. 10 (October 2011): 1001–16. http://dx.doi.org/10.1016/j.jaac.2011.07.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Preisig, M., and F. Ferrero. "Familial Risk Factors for the Course of Bipolar Disorder." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70292-5.

Full text

Abstract:

Aims:The major aims of the present paper were to:1.assess associations between the course of bipolar-I disorder in probands and the presence and course characteristics of mood disorders in their relatives and2.assess associations between manic and depressive symptoms in probands and relatives.Methods:A family study including 125 bipolar-I patients and all available first-degree relatives has been conducted at two Swiss sites. All participants were evaluated using the Diagnostic Interview for Genetic Studies. Assessed course variables included the age of onset, the number of episodes and social functioning in terms of GAF scores. Among the 237 interviewed relatives of bipolar probands, 32 also exhibited bipolar disorder.Results:The occurrence of bipolar disorders in relatives was not associated with course variables in bipolar probands, whereas the occurrence of unipolar depression in relatives was associated with a more favorable course in probands in terms of higher lifetime GAF scores. Regarding the expression of symptoms during episodes, associations between disorders in probands and relatives were observed for dysphoric and psychotic rather than for typical manic symptom patterns.Conclusion:Our data did not provide support for a significant association between the course of bipolar disorder and the presence or the course characteristics of bipolar disorders in relatives. Surprisingly, the presence of unipolar depression in relatives was even associated with a better course of the bipolar disorder in probands. Nevertheless, bipolar disorder revealed some degree of similarity across family members, particularly regarding the expression of dysphoric and psychotic symptom patterns.

APA, Harvard, Vancouver, ISO, and other styles

41

Leibenluft, Ellen. "Gender Differences in Major Depressive Disorder and Bipolar Disorder." CNS Spectrums 4, no. 10 (October 1999): 25–33. http://dx.doi.org/10.1017/s1092852900012335.

Full text

Abstract:

AbstractThis paper reviews the literature on gender differences in major depressive disorder (MDD) and bipolar disorder (BPD). Beginning in adolescence, women are at a higher risk than men of becoming depressed. Avenues of investigation that might ultimately help to explain this phenomenon include studies of gender differences in the processing of emotional stimuli, the psychotropic effects of gonadal steroids, and environment/gene interactions in men and women. With the exception of the elevated suicide rate among men, consistent gender differences in the course and symptoms of MDD have not been found. In BPD, women are more likely than men to develop a rapid-cycling course. Gender differences in treatment response, particularly in regard to mood stabilizing medications, warrant further study.

APA, Harvard, Vancouver, ISO, and other styles

42

Chopra, MohitP, KV Kishore Kumar, DK Subbakrishna, Sanjeev Jain, and RSrinivasa Murthy. "The course of bipolar disorder in rural India." Indian Journal of Psychiatry 48, no. 4 (2006): 254. http://dx.doi.org/10.4103/0019-5545.31559.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Gjerris, A., E. M. Christensen, and J. K. Larsen. "The course and outcome in bipolar affective disorder." European Psychiatry 13, S4 (1998): 188s. http://dx.doi.org/10.1016/s0924-9338(99)80205-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Johnson, Sheri L., Carol A. Winett, Bjorn Meyer, William J. Greenhouse, and Ivan Miller. "Social support and the course of bipolar disorder." Journal of Abnormal Psychology 108, no. 4 (November 1999): 558–66. http://dx.doi.org/10.1037/0021-843x.108.4.558.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Budde, Monika, and Thomas G. Schulze. "Neurocognitive Correlates of the Course of Bipolar Disorder." Harvard Review of Psychiatry 22, no. 6 (2014): 342–47. http://dx.doi.org/10.1097/hrp.0000000000000016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Birmaher, B. "Pediatric bipolar disorder- clinical picture and longitudinal course." International Clinical Psychopharmacology 28 (December 2012): e27. http://dx.doi.org/10.1097/01.yic.0000423279.42220.b7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Faedda, Gianni L., Ross J. Baldessarini, Ira P. Glovinsky, and Nancy B. Austin. "Pediatric bipolar disorder: phenomenology and course of illness." Bipolar Disorders 6, no. 4 (August 2004): 305–13. http://dx.doi.org/10.1111/j.1399-5618.2004.00128.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Rizvi, Syed Naveed Asif, Marie Whitty, and Robert Daly. "Hydrocephalus and bipolar affective disorder." Irish Journal of Psychological Medicine 28, no. 4 (December 2011): 222–23. http://dx.doi.org/10.1017/s0790966700011708.

Full text

Abstract:

AbstractBipolar disorder can emerge in the context of organic brain pathology. In the case presented, long-standing hydrocephalus was diagnosed in a man with relatively late-onset bipolar illness who presented initially with somewhat atypical, treatment-resistant depressive symptoms. Hypomania, followed by a rapid-cycling bipolar course, subsequently developed. This report reviews the association between bipolar disorder and hydrocephalus, and examines possible neurobiological mechanisms implicated in both conditions.

APA, Harvard, Vancouver, ISO, and other styles

49

Bardenshteyn, Leonid M., N. N. Osipova, Ya M. Slavgorodsky, N. I. Beglyankin, G. A. Aleshkina, and M. M. Turansky. "THE BIPOLAR AFFECTIVE DISORDER TYPE II." Medical Journal of the Russian Federation 24, no. 3 (June 15, 2018): 157–62. http://dx.doi.org/10.18821/0869-2106-2018-24-3-157-162.

Full text

Abstract:

The article presents review of modern publications concerning studies of bipolar affective disorder type II. The materials are summing up concerning national and international studies of characteristics of clinical course of depressions and hypo-maniacal states within the framework of bipolar affective disorder type II, problems of differential diagnostic of bipolar affective disorder within spectrum of affective pathology. The significance of studying of pre-morbid background in case of bipolar affective disorder type II, co-morbid states for prognosis of course of disease is demonstrated. The screening, diagnostic and estimated scales and questionnaires are considered including principles of their application as an add-on to actual international diagnostic systems ICD-10, DSM-IV-TR, DSM-V.

APA, Harvard, Vancouver, ISO, and other styles

50

Perlick, Deborah, Robert R. Rosenheck, John F. Clarkin, Jo Anne Sirey, Patrick Raue, Susan Greenfield, and Elmer Struening. "Burden experienced by care-givers of persons with bipolar affective disorder." British Journal of Psychiatry 175, no. 1 (July 1999): 56–62. http://dx.doi.org/10.1192/bjp.175.1.56.

Full text

Abstract:

BackgroundFamily members of patients with schizophrenia frequently report burdens associated with caring for their relatives.AimsWe evaluate the impact of illness beliefs on the burden reported by family care-givers of people with bipolar illness.MethodThe multivariate relationships between patient symptomatology and family illness beliefs and report of burden were examined at baseline among care-givers of 266 patients with Research Diagnostic Criteria-diagnosed bipolar illness who were subsequently followed for 15 months.ResultsAt baseline, 93% of care-givers reported moderate or greater distress in at least one burden domain. As a group, care-giver illness beliefs (illness awareness, perception of patient and family control) explained an additional 18–28% of variance in burden experienced beyond the effects of the patients clinical state and history.ConclusionsCare-givers of patients with bipolar illness report widespread burden that is influenced by beliefs about the illness.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!