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1
Minton, Tamara Warner. "Male Socialization Experience in Two Birth Cohorts." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc279402/.
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The purpose of this research was twofold; a quantitative examination of male socialization patterns along with an assessment of change over time in male socialization experiences. Men born in the 1950s and men born in the 1970s were compared to obtain an understanding of male socialization processes and possible changes since feminist issues have become a prevalent source of discourse in society. A survey questionnaire was utilized with a modified snowball sampling technique to explore male socialization experience. One hundred and one men participated in the project. Socialization experience for the men in this sample was five dimensional and while certain dimensions revealed change over time, others remained static. Findings indicate that quantitative measures can be successfully employed to study socialization processes.
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Prather, Diane. "PUBLIC RELIGIOUS PARTICIPATION: A COMPARISON OF THREE DISTINCT BIRTH COHORTS." Master's thesis, University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4279.
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Research has demonstrated that many factors affect levels of religiosity in American religion. This study extends the research on the relationship between cohort membership and public religious participation and individual personal involvement. Most of the research pertaining to the effects of cohort on religiosity has been devoted to comparisons between the Depression Era and Baby Boom Cohorts. This study extends research in this area by including Generation X to the extent possible. Using the General Social Surveys, this analysis employs an age/period/cohort analytical framework to examine religious involvement. Sociodemographic variables that are associated with religiosity are included in the analysis. Directions for future research on variations in religiosity measures are discussed.M.A.
Department of Sociology
Sciences
Applied Sociology
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Richmond, Rebecca Claire. "The application and development of causal inference methods in birth cohorts." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.690899.
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Cohort studies which recruit women during pregnancy or at birth and follow up their offspring over the lifecourse provide the opportunity to investigate intra-uterine and early-life exposures in relation to developmental characteristics and later-life outcomes. However, due to confounding and other limitations, identification of true causal risk factors has proved challenging. In the context of several large, population-based birth cohorts, I have applied a series of causal inference methods which aim to minimise problems afflicting observational epidemiology and provide greater insights into modifiable early-life risk factors. In this thesis, I systematically assess the different methods in turn within the context of each birth cohort and the scientific question being addressed.
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Bailey, Beth A., David Wood, and Darshan Shah. "Impact of Pregnancy Marijuana Use on Birth Outcomes: Results from Two Matched Population-Based Cohorts." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/7661.
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Objective: To examine associations between in utero marijuana exposure and birth outcomes.
Study design: In two separate cohorts (Appalachian, Rocky Mountain), data were collected from medical records. Marijuana exposure was positive based on urine drug screening at delivery, with nonexposed controls matched on multiple factors including other substance exposure.
Result: Marijuana-exposed newborns (n = 531) had significantly worse birth outcomes than controls (n = 531), weighing 218 g less, 82%, 79%, and 43% more likely to be low birth weight, preterm, or admitted to the NICU, respectively, and significantly lower Apgar scores.
Conclusion: Marijuana exposure in utero predicted newborn factors linked to longer-term health and development issues. Effects were not attributable to other comorbidities in this study due to rigorous matching and biochemical verification of marijuana and other drug use. Findings add to growing evidence linking marijuana exposure to adverse birth and longer-term outcomes. Women should be encouraged to avoid marijuana use during pregnancy.
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Ediev, Dalkhat. "Mortality compression in period life tables hides decompression in birth cohorts in low-mortality countries." Sapienza University of Rome, 2013. http://dx.doi.org/10.4402/genus-451.
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The rapid increase in human longevity has raised important questions about what implications this development may have for the variability of age at death. Earlier studies have reported evidence of a historical trend towards mortality compression. However, the period life table model, commonly used to address mortality compression, produces a compressed picture of mortality as a built-in feature of the model. To overcome this limitation, we base our study on an examination of the durations of exposure, in years of age, of birth cohorts and period life tables to selected short ranges of the death rate observed at old age. Overall, old-age mortality has been decompressing, cohort-wise, since the 1960s. This process may further indicate good prospects for ever-decreasing mortality. In the future, deaths may not be concentrated within a narrow age interval, but will instead become more dispersed, though at ever later ages on average.
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Nykjaer, Camilla. "Dietary patterns in pregnancy and offspring growth outcomes : a multi-country analysis of birth cohorts." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16844/.
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Fetal life and early childhood are periods of rapid growth and development and both serve as important indicators of health in later life. Maternal diet during pregnancy has been recognised as one of the major lifestyle factors influencing both fetal growth and long term health. The link between maternal dietary patterns and fetal growth has been examined to some extent, little however is known on the potential long term effects on child growth. Using data from three large international cohort studies, this thesis aimed to assess the effect of maternal dietary components and patterns during pregnancy on offspring growth. The literature review revealed a heterogeneous body of studies that was generally supportive of a positive association between a health conscious maternal dietary pattern during pregnancy characterised by high intakes of fruit, vegetables, water and wholegrains and offspring size at birth. The evidence relating later child growth to maternal diet in pregnancy was inconclusive mainly due to a lack of research as well as heterogeneity amongst studies. Analyses of the association between maternal alcohol intake and fatty fish consumption prior to and during pregnancy and offspring size at birth was explored; providing further support on the evidence of alcohol as a teratogen, even in low amounts in the first trimester of pregnancy. The evidence for fatty fish intake however was inconclusive. In order to facilitate between study comparisons, a common food grouping system was applied to dietary data from the three cohorts and principal component analysis was performed on energy adjusted dietary data. Two, four and seven components were derived from each cohort. However, the dietary patterns identified from the different cohorts did share some commonalities. In particular, a dietary pattern characterised by high positive correlations with fruit, water and unrefined grains and negative correlations with refined grains and chips, seemed to be present in all three datasets. These were also the components that showed the most convincing associations with offspring growth outcomes at birth and around 7 years of age, even after taking into account known confounders and assessing possible mediation by birth weight and gestational weight gain as well as effect modification by breastfeeding and maternal pre-pregnancy BMI status.
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Decoo, Ellen. "Changing Attitudes Toward Homosexuality in the United States from 1977 to 2012." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4091.
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Support for civil rights for gays and lesbians has been increasing nationally. Changes in attitudes may be due not only to the influence of younger, more progressive cohorts, but also to the influence of other factors such as education, religious attendance, political identity, and attitudes toward women's roles. This thesis utilized General Social Survey data from 1977 to 2012 and examined changes in response to attitudinal questions regarding civil rights for gays and lesbians, as well as demographic factors predictive of changing attitudes. Between 1977 and 2012, attitudes became more accepting of civil rights for homosexuals in the United States. Results from multivariate regression models indicate that younger birth cohorts are more accepting of civil rights for gays and lesbians, as are those with higher education. Higher tolerance of non-traditional roles for women is associated with the support of civil rights for gays and lesbians. In addition, religious attendance is negatively associated with acceptance of civil rights for homosexuals, whereas political identity has no association.
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Obolenskaya, Polina. "Attitudes towards family and marriage in time and context : using two British birth cohorts for comparison." Thesis, City University London, 2012. http://openaccess.city.ac.uk/2252/.
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With dramatic changes in family-related behaviours in the past 50 years, there has been an increasing awareness and acceptance of different family arrangements. Subsequently, measuring and studying people’s attitudes towards issues such as commitment to marriage, acceptance of alternative family forms, parental separation and gender roles has gained a lot of attention among those working in the fields of sociology, social psychology and demography. The majority of studies examining the relationship between family-related attitudes and behaviour have focused on either the selection or adaptation effects of attitudes, with fewer (particularly of those using British data) specifically addressing the possibility of both processes taking place. This study’s main goal is to address the latter using the data of two British cohorts born 12 years apart: the 1970 British Cohort Study (BCS) and the 1958 National Child Development Study (NCDS). The cohort’s attitudes are measured by a scale consisting of three items which relate to: marriage being a lifelong commitment, a divorce being easily obtainable these days and the acceptability of parental separation. This work adopts the perspective of value orientation and life course position which implies a recursive nature of attitudes and behaviour whereby behaviour is influenced by people’s values (the selection effect of attitudes) and these values, in turn, adjust following changes in people’s circumstances (the adaptation effect of attitudes). The availability of attitude statements at two time points for each cohort (at age 26 and 30 for BCS; at age 33 and 42 for NCDS) and rich partnership history data allows for such analyses to be carried out as the order of events can be established. Firstly, this research utilises bivariate and multivariate techniques to investigate the determinants of attitudes. Further, it implements regression analyses to explore the relationships between attitude scores and: a) transition to first marriage for non-cohabiting cohort members (BCS and NCDS); b) transition to first marriage of cohabiting cohort members (BCS) and c) dissolution of first marriage (NCDS). The main findings show some evidence of both the selection and adaptation effects of attitudes in relation to marital transitions for both cohorts, indicating the importance of attitudes in shaping people’s behaviour and at the same time showing the tendency of attitudes to change in line with an individual’s personal circumstances.
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Makovac, Marcus. "Conservative shift or business as usual? : A cross-generational study in levels of social conservatism." Thesis, Uppsala universitet, Statsvetenskapliga institutionen, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403138.
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The aim of this paper is to study generational differences in social conservatism. The research centered around three questions. Firstly, have levels of political social conservatism increased in the youngest generation as compared to previous. Secondly, does the presidential era a person was brought up in, explain differing levels of social conservatism. And lastly, does the results in the previous questions change when you look within the sub-group of subjects who self-identify as being conservative. To answer these questions, this study will analyse responses to question meant to operationalize social conservatism found in the General Societal Survey(GSS). And compare responses between generational birth-cohorts socialised under different presidents. Generally the results showed a decline in levels of social conservatism between generations and the youngest generation was no exception. The role of a presidential era in determining levels of social conservatism was practically non-existent. The results from questions one and two did not seem to change when looking within the subgroup of self-identifying conservatives.
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Vafeiadi, Marina 1983. "Effect of hormone disruptors on birth outcomes and child's anogenital distance." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/299377.
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Introduction: Persistent Organic Pollutants (POPs) include a wide range of synthetic chemical substances that are ubiquitous in the environment and are identified as endocrine disrupting chemicals (EDCs) which can alter the function of endocrine systems in humans and animals. Exposure to such chemicals during critical developmental phases, such as in utero has been associated with adverse reproductive and child health outcomes. Aims: The main aim of this thesis was to evaluate the effect of in utero exposure to hormone disruptors on birth outcomes and anogenital distance of the child in five European population-based cohort studies in Greece, Spain, England, Denmark and Norway. Methods: We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX®) bioassay. Concentrations of several PCBs and other organochlorine compounds (dichlorodiphenyl dichloroethene [DDE], dichlorodiphenyl trichloroethane [DDT] and hexachlorobenzene [HCB]), were determined in 1st trimester maternal serum by triple quadrupole mass spectrometry. Information on birth outcomes was retrieved from medical records. Anogenital distances were measured in newborn and young girls. Results: Plasma dioxin-like activity was higher in maternal than in cord blood samples. Newborns in the highest tertile of exposure had a reduction of approximately half a week in their gestational age as compared with those in the lowest tertile. This association was stronger in boys than in girls, although the statistical evidence for interaction was weak. Birth weight was negatively associated with increasing levels of HCB and PCBs. Adjustment for maternal gestational weight gain explained only to a small extent the association between POP levels and birth weight. Furthermore, in a stratified analysis, the association between POPs and birth weight was only observed in women with inadequate or excessive gestational weight gain. Anogenital distances were sexually dimorphic, being longer in males than females. Plasma dioxin-like activity was negatively associated with AGD (anogenital distance: anus to upper penis), in male newborns. Negative but smaller and nonsignificant associations were observed for AGD in young boys. No associations were found in girls. Negative but not statistically significant associations were
observed for AGD and HCB, DDE and total PCBs in young boys. In young girls, anoclitoral (ACD: anus to clitoris) and anofourchetal distance (AFD: anus to fourchette) were positively associated with all POPs. Conclusions: Results from these international general population studies suggest an association between low-level prenatal exposure to POPs and impaired fetal growth. Moreover, our results suggest that male infants may be susceptible to endocrine-disrupting effects of dioxins while associations with other POPs remain unclear.Introducció: Els contaminants orgànics persistents (COPs) inclouen una àmplia gamma de substàncies químiques sintètiques que són omnipresents en el medi ambient i són identificats com pertorbadors endocrins (EDC) que poden alterar la funció dels sistemes endocrins en els éssers humans i els animals. L'exposició a aquests productes químics durant fases crítiques de desenvolupament, com a l'úter, s'ha associat amb efectes adversos en la salut reproductiva i infantil. Objectius: L'objectiu principal d'aquesta tesi és avaluar l'efecte de l'exposició a l'úter als disruptors hormonals sobre el pes en néixer, l’edat gestacional i la distància anogenital dels nens en cinc estudis europeus de cohorts de base poblacional a Grècia, Espanya, Anglaterra, Dinamarca i Noruega . Mètodes: Es va mesurar l'activitat de tipus de dioxines (dioxin-like activity) en mostres de plasma de la sang materna i del cordó recollits en el part mitjançant el bioassaig Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX®). Les concentracions de diversos PCBs i altres compostos organoclorats (dicloroeteno diclorodifenil [DDE], diclorodifenil tricloroetà [DDT] i hexaclorobenzè [HCB]), es van determinar en sèrum matern del primer trimestre amb espectrometria de masses. La informació sobre els parts va ser recuperada dels registres mèdics. Les distàncies anogenitals es van mesurar en nadons i nens joves . Resultats: L'activitat de tipus de dioxines en plasma va ser més alta en les mares que en les mostres de sang de cordó. Els nounats al tercil més alt d'exposició van tenir una reducció d’aproximadament la meitat d'una setmana a l'edat gestacional, en comparació als del tercil inferior. Aquesta associació va ser més forta en els nens que en les nenes, encara que l'evidència estadística per a la interacció era feble. El pes en néixer es va associar negativament amb l'augment dels nivells de HCB i PCB. Ajustant per l'augment de pes matern gestacional explicava només una petita part de l'associació entre els nivells de COPs i el pes en néixer. A més, en una anàlisi estratificada, l'associació entre els contaminants orgànics persistents i el pes en néixer es va observar només en dones amb augment de pes gestacional inadequat o amb augment excessiu. Les distàncies anogenitals eren dimòrfiques, sent majors en els nens que en les nenes. L’activitat en plasma de tipus de dioxines es va associar negativament amb l'AGD (distància anogenital: anus al límit superior del penis) en els nadons mascles. Es van observar associacions negatives però més petites i no significatives per a l’AGD en els nens joves. No es van trobar associacions en les nenes. Es van observar associacions negatives, però no estadísticament significatives per a l’AGD i HCB, DDE i PCBs totals en els nens joves. En les nenes joves, les distàncies ACD (anus fins el clítoris) i AFD (anus a fourchette-llavis menors) es va associar positivament amb tots els COP. Conclusions: Els resultats d'aquests estudis internacionals de població general suggereixen una associació entre l'exposició prenatal de baix nivell als contaminants orgànics persistents i retard del creixement fetal. D'altra banda, els nostres resultats suggereixen que els nens mascles poden ser susceptibles als efectes d'alteració endocrina de dioxines mentre que les associacions amb altres COP són menys evidents.
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Lewis, Sarah. "A study of the aetiology of wheezing illness and allergic disease in children using data from the 1958 and 1970 British birth cohorts." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363934.
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Katzenellenbogen, Judy Masha. "An historical demographic investigation into mortality in three historical birth cohorts born between 1837 and 1900 in Mamre, with special reference to life expectancy." Master's thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/27192.
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This thesis reports on an historical prospective study of three Mamre decadal birth cohorts (1837-1846, 1870-1879, and 1900-1909) constructed retrospectively through existing parish records of the Moravian Mission at Mamre in the Western Cape region of South Africa. Nominative data collection techniques were used to gather information needed to determine the infant mortality rates, quinquennial mortality rates and life expectancies of the three cohorts. Issues related to the quality of data – non-registration and follow-up - were investigated. Birth registration was best for the 1837-46 cohort for males and females, with the 1900-1909 registration being next best. Overall, male registration coverage was substantially better than that for females. Infant death registration was best for males in these 2 cohorts, but were poor for females. Based on these data, the infant mortality rates for the cohorts born in 1837-1846, 1870-1879 and 1900-1909 - 196, 182 and 128 per 1000 respectively for males and 160, 172 and 97 per 1000 respectively for females - appeared to be underestimates. There is some evidence of a downward trend for the infant mortality rates with time for males, but this was not statistically significant. Quinquennial mortality rates for the 3 cohorts did not differ statistically, and are similar to the 1935-37 national 'coloured' figures. The life expectancies also did not differ significantly between cohorts. The life expectancies at birth (range 34- 40 years for males and 32-45 years for females) were probably overestimates due to biased IMR's. The life expectancies at age 1 (range 41-44 for males and 37-49 for females) were more representative figures. Life expectancies at age 20 were fairly stable over time (37-45 years) except for females in the 1900-1909 cohort whose life expectancies were substantially higher than earlier figures. All mortality indices investigated in this study consistently showed a lighter burden of mortality in historical Mamre compared to 'coloureds' in the Cape Colony at the turn of the century. This is probably associated with the better housing, environmental, social, economic and educational conditions at the Mamre mission relative to the rest of the Colony in the century after the emancipation of slaves.
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Keller, Theresa [Verfasser]. "The prevalence sex-shift in single disease and multimorbid asthma and rhinitis during puberty: an individual participant data meta-analysis of European birth cohorts / Theresa Keller." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1170876374/34.
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Milet, Jacqueline. "Étude de la composante génétique de la variabilité des infections palustres simples : Approche génome entier dans deux cohortes de jeunes enfants au Bénin First Genome-Wide Association Study of Non-Severe Malaria in Two Birth Cohorts in Benin Mixed logistic regression in Genome-Wide Association Studies." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASR013.
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Malgré les moyens importants de prévention et de lutte mis en place ces dernières années, le paludisme reste dévastateur avec près d’un demi-million de décès par an (405 000 en 2018, d'après le dernier rapport de l'OMS). Le rôle clé joué par les facteurs génétiques de l’hôte dans la susceptibilité et la sévérité de la maladie est admis aujourd'hui. Cependant, les bases moléculaires de la sensibilité/résistance au paludisme restent encore mal connues. Ces dix dernières années, les efforts de recherches pour l’identification de gènes impliqués dans la sensibilité au paludisme à P. falciparum se sont concentrés sur les formes graves de paludisme, avec plusieurs plusieurs études d’association sur l’ensemble du génome (Genome-Wide Association Study ou GWAS) publiées. Ce manuscrit porte sur l’extension de cette approche aux formes simples du paludisme, au travers de l’étude d’association génome entier de deux cohortes de nouveau-nés au Sud Bénin (au total 800 enfants), suivis pendant 18-24 mois par l’UMR261 (MERIT IRD/Université de Paris). Dans une première partie nous présentons les résultats de la première GWAS réalisée sur les formes simples de paludisme dans ces deux cohortes. L’association a été testée avec la récurrence des accès palustres et la récurrence de l’ensemble des infections (incluant les accès palustres et les infections asymptomatiques) en prenant en compte un risque environnemental estimé au niveau individuel. Elle met en évidence plusieurs signaux d’association forts, en lien avec des gènes dont la fonction biologique est pertinente pour le paludisme (notamment PTPRT, MYLK4, UROC1 et ACER3). La forte variabilité génétique présente au sein des populations africaines a nécessité de prendre en compte l’effet de confusion potentiel de la structure de population. Dans l’étude les formes simples de paludisme, une approche en deux étapes a été utilisée, le modèle de Cox mixte, utilisé pour l’analyse des données longitudinales, n’étant pas applicable à l’ensemble du génome du fait du temps de calcul nécessaire. Un modèle de Cox mixte a été appliqué pour construire un « effet individuel » ajusté sur les covariables, puis un modèle mixte linéaire pour tester l’association avec les polymorphismes du génome. Ceci nous a conduits à nous intéresser plus généralement aux modèles mixtes non-linéaires. Deux méthodes permettant l’estimation de l’effet des polymorphismes avec le modèle logistique mixte sont proposées, qui pourront être dans le futur généralisé à d’autres modèles, dont le modèle de Cox. Dans une dernière partie, le paludisme ayant constitué une des plus fortes pressions de sélection que l’homme ait connue dans son histoire récente, nous explorons la possibilité d’exploiter l’information de sélection naturelle pour augmenter la puissance de l’analyse, et améliorer la détection des signaux d’association. L’analyse des signaux de sélection positive récente sur l’ensemble du génome a été réalisée avec plusieurs méthodes basées sur les haplotypes longs ((iHS, nsL and XP-EHH). Celle-ci met en évidence plusieurs régions chromosomiques d’intérêt potentiel où les signaux d’association et de sélection co-localisent ; mais confirme également la difficulté à mettre en évidence les signaux de sélection liés au paludisme avec les outils disponibles actuellementIn spite of numerous prevention and control efforts in recent years, malaria remains a major global public health problem with nearly half a million deaths per year (405,000 in 2018). The key role played by genetic factors of the host in the susceptibility and severity of the disease is is admitted nowadays. However, the molecular basis of susceptibility / resistance to malaria has not been elucidated to date. Over the past decade, research efforts to identify genes involved in malaria susceptibility have focused on severe malaria, with several genome-wide association studies (GWAS) published. This manuscript concerns the extension of this approach to uncomplicated forms of malaria, through the genome wide association study of two birth cohorts in South Benin (800 children), followed for 18-24 months by UMR261 (MERIT IRD / University of Paris).In the first part, we present the results of the first GWAS performed on simple forms of malaria in these two cohorts. The association was tested with the recurrence of malaria attacks and the recurrence of all infections (including malaria attacks and asymptomatic infections) taking into account an environmental risk estimated at the individual level. It highlights several strong association signals, linked to genes whose biological function is relevant for malaria (in particular PTPRT, MYLK4, UROC1 and ACER3). The high genetic diversity within African populations has made it necessary to take into account the potential confounding effect of population structure. In this study we proceeded with a two-step strategy as the Cox mixed model, used for the analysis of longitudinal data, is not applicable to the whole genome due to computational burden. In a first step, an analysis was performed with a Cox mixed model to build an "individual effect" fitted on the covariates, then a linear mixed model were used to test the association with genome polymorphisms. This led us to focus more generally on non-linear mixed models. Two methods allowing the estimation of the effect of polymorphisms with the mixed logistic model are proposed, which may in the future be generalized to other models, including the Cox model.In a final part, malaria having been one of the strongest selection pressures that man has known in recent history, we explore the possibility of exploiting natural selection information to increase the power of analysis, and improve the detection of association signals. The analysis of recent positive selection signals were performed using several genome-scan methods focusing on patterns of long-range haplotype homozygosity (iHS, nsL and XP-EHH). This analysis revealed several chromosomic region of potential interest, where the signals of association and selection co-localized but confirms also the difficulty of highlighting the selection signals linked to malaria with tools currently available
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Schwartz, Danielle. "Justice entre classes d’âge. Au-delà de l’égalité entre les vies complètes." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUL151.
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La justice entre les classes d’âge est un domaine encore sous-étudié. Il n’est pas évident de savoir a priori comment traiter de manière équitable deux personnes d’âge différent. L’égalité doit-elle être respectée à chaque moment de la vie de ces personnes ou bien suffit-il de se concentrer sur l’égalité entre leurs vies complètes? Y a t-il des raisons de privilégier les âgés ou les plus jeunes ? L’égalité entre les classes d’âge constitue t-elle le seul objectif à poursuivre ou bien faut-il s’intéresser aussi aux inégalités au sein d’une même classe d’âge ? Faut-il se préoccuper de ce que les espérances des vies des individus sont différentes ? Voilà quelques-unes des questions auxquelles cette thèse a pour ambition de répondre. On trouvera dans la présente thèse l’élaboration d’une théorie complète de la justice entre les classes d’âge avec ses fondements et ses justifications ainsi que son application à des politiques publiques contemporainesJustice between age groups is an understudied aera in political philosophy. What does it mean to treat different age groups as equals ? Should we apply egalitarian comparison to people born at different times at this specifcic point in time or over the course of their lives ? Is it permissible to give higher priority to policies that primarly benefit the youngsters ? Don’t inequalities among age groups matter as well as inequalities between age groups ? Should we take the risk of premature death into account ? The present PhD thesis establishes a theoritical framework for age-group justice and makes explicit its implications for practical policy discussions and proposals
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Būtienė, Indrė. "Food allergy in Lithuanian birth cohort." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2013~D_20131209_091502-26385.
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Environmental factors more often is thought to have influence in determining children’s health and development. Prevalence of allergic diseases over the last decades is increasing, especially in Western Europe. Despite lots of performed surveys it is still unclear why the prevalence of food allergy is mounting. Incidence of food allergy is age dependent and usually manifest as one of the first forms of allergy. It is considered as the first step of „atopic march“. To accurately assess the occurrence of possible risk factors for a disease that can start already in infancy and may resolve by school age, a prospective birth cohort with regular follow-up of participating children and families provides the best possible study design.
EuroPrevall birth cohort study, in which participated Vilnius University, was the first in the world investigation specially created just for evaluation of food allergy. During in this dissertation presented project for the first time real prevalence of food hypersensitivity and allergy in infants and small children in Lithuania have been determined, the most common food allergens were assessed and changes in prevalence of sensitization to them during first 30 months of life were analysed, also the role of possible determinants for the development of food allergies, such as genetic background, maternal diet during pregnancy and breastfeeding, way of birth, infections, medicines, psycho-social and environmental factors, were examined and different... [to full text]Svarbus vaidmuo, nulemiantis vaikų sveikatą ir vystymąsi, vis dažniau priskiriamas vaiką supančiai aplinkai. Sergamumas alerginėmis ligomis sparčiai didėja, o pastaraisiais dešimtmečiais jis itin išaugo, ypač Vakarų Europoje. Nepaisant daugelio atliktų tyrimų, vis dar lieka neaišku, kodėl alerginių ligų paplitimas nuolat didėja. Alergijos maistui paplitimas įvairiose amžiaus grupėse skiriasi ir yra viena iš anksčiausiai pasireiškiančių alergijos formų. Manoma, kad ji gali būti pirmasis „atopinio maršo“ žingsnis. Norint tiksliai įvertinti galimų rizikos veiksnių įtaką ligos atsiradimui, kuri gali prasidėti jau kūdikystėje ir išnykti iki mokyklinio amžiaus, tinkamiausias tyrimo metodas yra prospektyvinis naujagimių kohortos tyrimas su reguliaria į tyrimą įtrauktų vaikų ir jų šeimų stebėsena. EuroPrevall naujagimių kohorta - tai pirmasis pasaulyje tyrimas, kuriame dalyvavo ir Vilniaus Universitetas, specialiai suformuotas tik alergijos maistui ištyrimui. Šio disertacijoje pateikiamo tyrimo metu Lietuvoje pirmąkart ištirtas padidėjusio jautrumo maistui ir alergijos maistui paplitimas tarp mažų vaikų ir nustatyti dažniausiai alergiją sukeliantys maisto produktai ir sensibilizacijos maisto alergenams kaita pirmaisiais 30 gyvenimo mėnesiais, taip pat išanalizuoti tėvų ir kūdikių rizikos veiksniai, tokie kaip genetinis pagrindas, mamos mityba nėštumo metu ir žindant, gimdymo būdas, infekcijos, vartoti medikamentai, psicho-socialiniai ir aplinkos faktoriai, įtakojantys alergijos... [toliau žr. visą tekstą]
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Ghosh, Rebecca. "Asthma and occupation in the 1958 birth cohort." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9165.
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Exposures encountered in the workplace are a common contributor to adult asthma, accounting for an estimated 10% all new or recurrent disease. Work-related asthma is potentially preventable and identification of occupational causes may lead to interventions to reduce its burden. Currently most information about the burden of asthma in the workplace is based on cross-sectional data or surveillance data and no British longitudinal population based studies have been carried out to look at this problem. This study aimed to identify the major occupations and occupational exposures that are associated with respiratory symptoms, asthma and other allergic disease in the British population. This study also aimed to assess the advantages and disadvantages of using a job exposure matrix in exposure assessment for population based asthma research. This study made use of data from the 1958 Birth Cohort. An occupational history from entry to the workforce at age 16 up to age 42 was created. Blind to asthma status over 80,000 jobs were checked and re-coded to the International Standard Classification of Occupations 1988 (ISCO-88) codes. This information was merged with an asthma specific job exposure matrix and underwent an expert review of the exposure assignment and occupational coding. Several job categories and ASJEM exposures were associated with adult onset asthma by age 42. This PhD confirms in a British population existing knowledge about occupations and occupational exposures associated with the development of asthma in working life. In particular it shows consistent evidence of asthma development in those who have ever worked as a cleaner or have been exposed to Low Molecular Weight cleaning chemicals.
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Hill, Rebecca. "Internet adoption among older people : a birth cohort study." Thesis, Swansea University, 2008. https://cronfa.swan.ac.uk/Record/cronfa42989.
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The aim of this research is to investigate the process of Internet adoption among a cohort of older people who reached their formative years historically prior to the public emergence of the Internet, and who have gained no previous exposure to the Internet in their educational and working lives. This research is based on an ethnographic research study of a number of participants who attended one-off, introductory Internet workshops. It is situated within an interpretive paradigm. The research involved a follow-up of research participants approximately six months after their workshop attendance. This research employs Everett Rogers' (2003) theory of the Diffusion of Innovations, and draws on diverse literatures from Information Systems, Sociology, Gerontology and Gerontechnology. It investigates why the aforementioned cohort of older people may be adopting (or rejecting) the Internet; how they are adopting; and how this process can occur over time. It also proposes a potential means for accelerating Internet adoption among older people. The results of this research reveal that the process of Internet adoption characterising this specific cohort can be long and complex, and can be shaped by social network ties. The influence of strong ties was most evident, but weak ties were also important. The influence of both strong and weak ties is emphasised in the proposal of community networks and of intra- and intergenerational partnerships, which are recommended as community-based, 'home-from-home' environments in which older people (and other social groups) can 'trial' the Internet and observe it in use by others.
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Heikura, U. (Ulla). "Intellectual disability in the Northern Finland Birth Cohort 1986." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514287114.
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Abstract The objective of this study was to investigate intellectual disability (ID) in children, with focus on occurrence, associated biomedical and sociodemographic factors, probable psychiatric problems and temporal variations in the occurrence of ID and the associated factors in an interval of 20 years. The study population consisted of two birth cohorts of children born in northern Finland, the Northern Finland Birth Cohort 1986 (NFBC 1986, N = 9,432 live-born children) and the Northern Finland Birth Cohort 1966 (NFBC 1966, N = 12,058 live-born children). Temporal changes in ID were studied by comparing NFBC 1986 with NFBC 1966. The same definition of intellectual disability (intelligence quotient ≤70), time of follow-up (up to 11.5 years), case ascertainment methods and data sources were used. Data were collected from questionnaires, registers and records. In NFBC 1986 the incidence of ID was 12.62/1,000 by age 11.5 years and prevalence 11.23/1,000 live-born at age 11.5 years. Associated biomedical aetiology could be found in two thirds of the cases. Genetic disorders were the largest aetiological category (36.1%) associated with ID. Maternal disadvantage (unskilled worker, basic education only) had the largest impact on the incidence of ID, while among single independent factors, maternal prepregnancy obesity (body mass index ≥30) showed the highest risk for ID (OR 2.8, 95% CI 1.5, 5.3) in the offspring. According to the assessments by the teachers at school children with ID had 4.9 times more likely probable behavioural problems than their peers not having ID. In an interval of 20 years, there was no change in the incidence or in the prevalence of ID between NFBC 1986 and NFBC 1966. However, a shift occurred from more severe levels of ID towards mild ID, so that both the incidence and prevalence of mild ID increased by 50% whereas more severe ID decreased by 50%. Temporal changes appeared in the proportions of aetiological categories (NFBC 1986 vs. NFBC 1966) with a statistically significant decrease of Down syndrome and paranatally originating causes (traumas/asphyxia). The proportion of chromosomal disorders other than Down syndrome increased, as did malformations of the central nervous system. Among sociodemographic factors associated with ID, indicators of socio-economic disadvantage retained their status as having the largest impact on the incidence of ID. Over the 20 years, the mother being single, living in a remote area and mother's older age at time of delivery had lost their association with ID. Only one new maternal sociodemographic factor, prepregnancy obesity, had emerged as having an association with ID with a statistically significant difference between NFBC 1986 and NFBC 1966. In conclusion, these results indicate that although the occurrence of ID remained the same in northern Finland over a period of 20 years, temporal changes have taken place in the biomedical and sociodemographic factors contributing to the incidence and prevalence of ID. There are also factors that have retained their status as associated disadvantageous factors. Studies like this with repeatedly collected data in the same geographical area, describing the occurrence of ID, and analysing associated biomedical and sociodemographic factors, are valuable for evaluating developments in the health care and service system. They are also of value for future planning of services for individuals with IDTiivistelmä Tämän tutkimuksen tavoitteena oli selvittää kehitysvammaisuuden esiintyvyyttä lapsilla, siihen liittyviä lääketieteellisiä etiologisia ja sosiodemografisia tekijöitä, mahdollisia psykiatrisia ongelmia sekä kehitysvammaisuuden esiintyvyydessä ja siihen liittyvissä tekijöissä tapahtuneita muutoksia 20 vuoden aikana. Tutkimusjoukko muodostui kahden syntymäkohortin lapsista, jotka olivat syntyneet Pohjois-Suomessa, Pohjois-Suomen syntymäkohortti 1986 (NFBC 1986, N = 9432 elävänä syntynyttä lasta) ja Pohjois-Suomen syntymäkohortti 1966 (NFBC 1966, N = 12058 elävänä syntynyttä lasta). Kehitysvammaisuudessa tapahtuneita ajallisia muutoksia tutkittiin vertaamalla Pohjois-Suomen syntymäkohortti 1986:ta Pohjois-Suomen syntymäkohortti 1966:een. Tutkimuksessa käytettiin samaa kehitysvammaisuuden määritelmää (älykkyysosamäärä ≤70, seuranta-aika 11.5 vuoteen saakka), tiedonkeruun menetelmiä ja tietolähteitä. Tiedot kerättiin kyselylomakkeista, rekistereistä ja asiakirjoista. Pohjois-Suomen syntymäkohortti 1986:ssa kehitysvammaisuuden ilmaantuvuus oli 12.62/1000 11.5 vuoden ikään mennessä ja vallitsevuus 11.23/1000 11.5 vuoden iässä. Kehitysvammaisuuteen liittyvä lääketieteellinen etiologia pystyttiin selvittämään kahdessa kolmasosassa tapauksia. Geneettiset häiriöt muodostivat suurimman etiologisen luokan (36.1%). äitiin liittyvillä epäedullisilla sosiaalisilla tekijöillä (kouluttamaton työntekijä, vain peruskoulutus) oli suurin vaikutus kehitysvammaisuuden ilmaantuvuuteen, kun taas yksittäisistä sosiodemografisista tekijöistä korkein riski (vaarasuhde 2.8, luottamusväli 1.5, 5.3) oli äidin lihavuudella (painoindeksi ≥30) raskauden alussa. Koulussa opettajien arvioiden mukaan kehitysvammaisilla lapsilla esiintyi mahdollisia käytöshäiriöitä 4.9 kertaa useammin kuin ei-kehitysvammaisilla lapsilla. 20 vuoden aikana Pohjois-Suomen syntymäkohorttien 1986 ja 1966 välillä ei ollut tapahtunut muutoksia kehitysvammaisuuden kokonaisilmaantuvuudessa eikä -vallitsevuudessa. Kuitenkin tuli esiin siirtymä vaikeammasta lievempään asteeseen siten, etta lievän kehitysvammaisuuden ilmaantuvuus ja vallitsevuus lisääntyivät noin 50%, kun taas vaikeamman väheni 50%. Lääketieteellisten etiologisten luokkien osuuksissa tuli esiin ajallisia muutoksia (Pohjois-Suomen syntymäkohortti 1986 vs. Pohjois-Suomen syntymäkohortti 1966) siten, että Downin syndrooman sekä syntymän aikaan ajoittuvan vamman ja hapenpuutteen osuudet vähenivät tilastollisesti merkitsevästi. Keskushermoston epämuodostumien sekä muiden kromosomihäiriöiden kuin Downin syndrooman osuudet kasvoivat. Kehitysvammaisuuteen liittyvistä sosiodemografisista tekijöistä sosioekonomisen huono-osaisuuden osoittimet säilyttivät asemansa suurimpana ryhmänä. 20 vuoden aikana äidin naimattomuus, asuminen syrjäseudulla sekä korkeampi ikä lapsen syntymän aikaan olivat menettäneet yhteytensä kehitysvammaisuuteen. Pohjois-Suomen syntymäkohortti 1986:n ja Pohjois-Suomen syntymäkohortti 1966:n välillä tuli esiin vain yksi uusi kehitysvammaisuuteen tilastollisesti merkitsevästi liittyvä sosiodemografinen tekijä, äidin lihavuus raskauden alussa. Yhteevetona voidaan todeta, etta vaikka kehitysvammaisuuden kokonaisesiintyvyys oli pysynyt samana Pohjois-Suomessa 20 vuoden aikana niin esiintyvyyteen liittyvät etiologiset ja sosiodemografiset tekijät olivat osittain muuttuneet. Tämänkaltaiset tutkimukset, joissa peräkkäisinä ajanjaksoina kerätään tietoja samalla maantieteellisellä alueella ja jotka kuvaavat kehitysvammaisuuden esiintyvyyttä sekä analysoivat siihen liittyviä lääketieteellisiä ja sosiodemografisia tekijoitä, ovat hyödyllisiä arvioitaessa terveydenhoidossa ja palvelujärjestelmässä tapahtunutta kehitystä. Niitä voidaan hyödyntää myös suunniteltaessa tulevaisuudessa palveluja kehitysvammaisille henkilöille
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Alves, Elisabete Cristina Macedo. "Cardiovascular risk profile in mothers of a portuguese birth cohort." Tese, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63791.
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Karvonen, J. T. (Juha T. ). "Somatization in young adults:the Northern Finland 1966 Birth Cohort Study." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285547.
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Abstract Somatization is a widespread phenomenon causing subjective suffering and disability. The aim of the study was to assess somatization disorder (SD) and somatization symptoms among young adult population and their associations with sociodemographic factors, alexithymia and temperament as well as psychiatric comorbidity. Various suggestions have been presented to operationalize somatization but none of them has been shown to be superior to others. In this study two definitions were used: SD by DSM-III-R classification diagnostic criteria and "somatization" meaning four or more symptoms of the 35 symptoms of DSM-III-R SD criteria. The study population was a subsample of the Northern Finland Birth Cohort 1966 (NFBC 1966), consisting of cohort members living in Oulu (N = 1,609) on January 1st 1997. The NFBC 1966 is a general population birth cohort of 12,058 live-born children covering 96.3% of all deliveries in the catchment area. The best-estimated procedure was used for assessment of psychiatric morbidity including SD and somatization. Data were collected from the Finnish Hospital Discharge Register and from all available outpatient and inpatient records. Data on education were gathered from Statistics Finland. Other sociodemographic variables, alexithymia and temperament scores were drawn from questionnaires of the field study conducted in 1997 and from earlier follow-up studies. The prevalence of SD was 1.1% (N = 18). Of the subjects 6.1% (N = 97) had somatization. The female-to-male ratio was 5:1 and 6:1, respectively. SD was not recognized by any of the treating physicians, at least not documented in case notes. The observed occurrences of SD and somatization were at a level comparable with earlier international population studies. Somatization did not associate with depression or alexithymia, and neither could a characteristic temperament profile be recognized. Somatization was associated with psychological distress. These results indicate a need for training physicians to recognize SD and somatization and its comorbidity. This will have implications both for psychiatry and other medical specialties regarding collaboration and underlines the importance of liaison-psychiatry at general hospitals. The results suggest a need for more studies about the etiology and development of SD and somatizationTiivistelmä Somatisaatio on yleinen ilmiö, josta aiheutuu subjektiivista kärsimystä ja toimintakyvyn laskua. Tämän tutkimuksen tarkoitus oli arvioida somatisaatiohäiriön ja somatisaatio-oireilun yleisyyttä nuorilla aikuisilla sekä näiden ilmiöiden yhteyttä sosiodemografisiin tekijöihin, aleksitymiaan, temperamenttiin ja psykiatriseen sairastavuuteen. Somatisaation käsitteellistämiseksi on esitetty useita vaihtoehtoja mutta mikään niistä ei ole osoittautunut muita paremmaksi. Tässä tutkimuksessa käytetiin kahta määritelmää: DSM-III-R -diagnoosiluokituksen mukaista somatisaatiohäiriön diagnoosia tai somatisaatio-oireilua, jossa esiintyy neljä tai useampia DSM-III-R:n 35 somatisaatiohäiriön oireesta. Tutkimusaineiston muodostivat Pohjois-Suomen vuoden 1966 syntymäkohortin ne jäsenet, jotka asuivat Oulussa 1. tammikuuta 1997 (N = 1,609). Alkuperäinen kohortti koostuu 12,058 elävänä syntyneestä tutkittavasta, mikä kattaa 96.3 % kaikista synnytyksistä Pohjois-Suomessa. Niin kutsutun best-estimated -menettelyn avulla arvioitiin tutkittavien psykiatrista sairastavuutta mukaan lukien somatisaatiohäiriö ja -oireilu. Tietoa kerättiin sairaaloiden poistoilmoitusrekisteristä. Avohoidon sairauskertomustieto koottiin kattavasti. Koulutusasteesta saatiin tieto Tilastokeskukselta. Muita sosiodemografisia tekijöitä, aleksitymiaa ja temperamenttia arvioitiin vuoden 1997 kenttätutkimuksen ja aiempien seurantatutkimusten tietojen avulla. Somatisaatiohäiriön esiintyvyys oli 1.1 % (N = 18). Somatisaatio-oireita todettiin 6.1 % (N = 97) tutkittavista. Naisten osuus oli somatisaatiohäiriössä 5:1 ja somatisaatio-oireilussa 6:1. Osoittautui, että lääkärit eivät tunnistaneet somatisaatiohäiriötä, ainakaan sitä ei oltu kirjattu sairauskertomuksiin. Havaitut somatisaatiohäiriön ja -oireilun esiintyvyydet ovat sopusoinnussa aiempien kansainvälisten tutkimusten kanssa. Somatisaatio-oireilu ei liittynyt masennukseen tai aleksitymiaan eikä somatisaatio-oireilusta kärsiville tutkittavilla todettu tyypillistä temperamenttiprofiilia. Somatisaatio liittyi psyykkiseen stressiin. Johtopäätöksenä voidaan todeta, että lääkäreille tulisi tarjota koulutusta somatisaatiohäiriön ja -oireilun tunnistamisessa. On tärkeää tunnistaa somatisaatio ja siihen liittyvä oheissairastavuus. Havainnot korostavat yleissairaaloiden yhteistyöpsykiatrian ja muiden erikoisalojen yhteistyön merkitystä somatisaatiosta kärsivien potilaiden tutkimuksessa ja hoidossa. Somatisaatiohäiriön ja -oireilun etiologian ja kehittymisen selvittämiseksi tarvitaan uusia tutkimuksia
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Kantojärvi, L. (Liisa). "Personality disorders in the Northern Finland 1966 Birth Cohort Study." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288487.
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Abstract Personality disorders (PDs) are relatively common mental disorders associating with other psychiatric disorders and disability. The aim of the study was to determine the occurrence of PDs in a general population subsample and psychiatric hospital patients, the associations of PDs with childhood family structure, the co-occurrence of PD with common psychiatric disorders, and the associations between PDs and temperament. The study is part of the Northern Finland 1966 Birth Cohort Project (NFBC 1966), consisting of cohort members living in Oulu (N = 1,609) on 1st January 1997 (the Oulu Study). The study consisted of a two-stage psychiatric field survey with questionnaires and a structured clinical interview and analysis of the patient records in public outpatient care. Information concerning psychiatric illness of all cohort members (N = 12,058) was gathered from the Finnish Hospital Discharge register (FHDR). The best-estimate procedure was used for the assessment of psychiatric morbidity including PDs. Childhood family structure and other sociodemographic variables were drawn from questionnaires of the field study conducted during earlier follow-up studies. In this study PDs were classified into three clusters: Cluster A (paranoid, schizoid and schizotypal PD), Cluster B (antisocial, borderline, histrionic, and narcissistic PD), and Cluster C (avoidant, dependent, obsessive-compulsive, and passive-aggressive PD). The most common PDs in the Oulu Study sample were Cluster C PDs, whereas Cluster B PDs were most common in the hospital-treated sample. PDs were highly associated with mood, anxiety and substance use disorders. Single-parent family type in childhood was associated with PDs, especially Cluster B PDs in adulthood. PD clusters were associated with different profiles of temperament, but the temperament dimensions could not distinguish different PDs very well. These results indicated that it is important to recognize PDs and their comorbid psychiatric disorders. This will have implications in both general outpatient care and psychiatry. These results indicate the importance of recognition of childhood risk factors for PDs for the prevention of severe PDs. The results suggest a need for more studies about the aetiology and development of PDsTiivistelmä Persoonallisuushäiriöt ovat yleisiä mielenterveyden ongelmia, joihin liittyy usein psykiatrista oheissairastavuutta ja toimintakyvyn laskua. Tämän tutkimuksen tarkoituksena oli arvioida persoonallisuushäiriöiden yleisyyttä nuorilla aikuisilla. tehtävänä oli arvoida yhteyksiä lapsuuden perherakenteeseen ja yleisimpiin psykiatrisiin häiriöihin sekä arvioida persoonallisuushäiriöiden yhteyksiä temperamenttitekijöihin. Tutkimus on osa Pohjois-Suomen vuoden 1966 syntymäkohortin psykiatrista osaprojektia, Oulu Studyä. Tutkimusaineiston muodostivat Oulu Studyn otokseen kuuluvat kaikki 1. tammikuuta 1997 Oulussa asuneet kohortin jäsenet (N = 1 609) sekä sairaalahoidossa olleiden persoonallisuushäiriö- diagnoosin saaneiden osalta koko alkuperäisen syntymäkohortin (N = 12 058) jäsenet. Tutkimus koostui kaksivaiheisesta psykiatrisesta kenttätutkimuksesta, jossa tietoja tutkittavilta kerättiin sekä kyselylomakkeiden ja haastattelututkimuksen avulla. Lisäksi tutkittavilta kerättiin tiedot heidän elinaikanaan toteutuneesta julkisten psykiatristen sairaala- ja avohoitopalvelujen käytöstä sairauskertomustietojen perusteella. Niin kutsutun best-estimated -menetelmän avulla arvioitiin tutkittavien psykiatrista sairastavuutta mukaan lukien persoonallisuushäiriöt. Tutkittavien lapsuuden perherakennetta ja sosiodemografisia tekijöitä arvioitiin aiempien seurantatutkimusten tietojen avulla. Tutkimuksessa persoonallisuushäiriöt luokiteltiin DSM-III-R-diagnoosiluokituksen mukaisesti kolmeen eri pääryhmään ja niiden mukaisiin alaryhmiin: Ryhmä A (epävakaa, eristäytyvä ja psykoosipiirteinen persoonallisuus), ryhmä B (epäsosiaalinen, epävakaa, huomionhakuinen ja narsistinen persoonallisuus) ja ryhmä C (estynyt, riippuvainen, pakko-oireinen ja passiivis-aggressiivinen persoonallisuus). Oulu Studyn väestöotoksessa yleisimpiä näistä olivat ns. C-ryhmän persoonallisuushäiriöt, kun taas sairaalahoidetuilla henkilöillä B-ryhmän persoonallisuushäiriöt olivat yleisimpiä. Persoonallisuushäiriöiden todettiin liittyvän yleisesti masennus- ja ahdistuneisuushäiriöihin sekä päihteiden käyttöön. Vanhemman yksinhuoltajuuden todettiin liittyvän persoonallisuushäiriöihin, etenkin B-ryhmän persoonallisuushäiriöihin. Persoonallisuushäiriöryhmät erosivat toisistaan temperamenttiprofiilien perusteella. Eri persoonallisuushäiriöistä kärsivillä tutkittavilla ei todettu tyypillisiä temperamenttiprofiileja. Johtopäätöksenä voidaan todeta, että persoonallisuushäiriöiden ja niihin yleisesti liittyvän psykiatrisen oheissairastavuuden tunnistaminen on tärkeää. Havainnot korostavat perusterveydenhuollon ja erikoissairaanhoidon yhteistyön merkitystä persoonallisuushäiriöistä ja psykiatrisista häiriöistä kärsivien henkilöiden tutkimuksessa ja hoidossa. Persoonallisuushäiriöille altistavien lapsuuden tekijöiden tunnistaminen on tärkeää vaikeiden persoonallisuushäiriöiden ehkäisemiseksi. Persoonallisuushäiriöiden etiologian ja kehittymisen selvittämiseksi tarvitaan uusia tutkimuksia
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Alves, Elisabete Cristina Macedo. "Cardiovascular risk profile in mothers of a portuguese birth cohort." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63791.
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Miller, B. (Brian). "Paternal age, psychosis, and mortality:the Northern Finland 1966 Birth Cohort, Helsinki 1951–1960 Schizophrenia Cohort, and Finnish Nonaffective Psychosis Cohort." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295898.
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Abstract There is an extensive literature on advanced paternal age (APA) as a risk factor for a wide variety of adverse health outcomes in the offspring that occur throughout the lifespan. APA is also a well-replicated and relatively robust risk factor for schizophrenia in the offspring. The aim of this study was to investigate advanced paternal age (APA) as a risk factor for schizophrenia and mortality in the offspring in four perspectives and original publications. The Northern Finland 1966 Birth Cohort (NFBC 1966) consists of 12,068 pregnant women with expected dates of delivery in 1966, and their 12,058 live-born children. The data used here were collected prospectively for 11,058 singleton-birth cohort members who were living in Finland at age one. The Helsinki 1951–1960 Schizophrenia Cohort consists of 529 persons born in Helsinki, Finland, between January 1, 1951 and December 31, 1960, who developed nonaffective psychosis before 1999. The Finnish Nonaffective Psychosis Cohort (Finnish NAP Cohort) consists of all 13,712 persons born in Finland between 1950 and 1969, who developed nonaffective psychosis before 1992. Both APA (≥30) and younger paternal age (<25) increased the risk of schizophrenia; younger paternal age may be associated with an increased risk in males but not females. In the general population, APA was associated with increased all-causes mortality and suicide in females but not males. Within NAP, in females but not males, there was a significant increase in all-causes mortality and natural deaths in offspring of fathers age ≥40. In both the general population and within NAP, APA was associated with having a mother with schizophrenia. An understanding of APA has substantial public health potential, as average paternal ages are increasing, and APA is common, has widespread effects, and is potentially preventable. We have provided important information for future epidemiological and clinical studies of all conditions associated with APA. Accounting for the APA effect as a potential confounding factor may also increase the signal-to-noise ratio in other epidemiological and genetic analyses. Our results have generated new and more refined hypotheses regarding psychosocial and/or biological mechanisms of the APA effect, and lay the foundation for animal models for its mechanism of action. Subsequent studies will be important to clarifying the pathophysiology of a potentially preventable determinant of schizophrenia and mortalityTiivistelmä Isän korkean iän (advanced paternal age, APA) on havaittu olevan yhteydessä laajaan kirjoon eri terveysongelmia. Aiemmassa tutkimuksessa havaittiin APA:n liittyvän tyttärien ylikuolleisuuteen, mutta pojilla vastaavaa yhteyttä ei havaittu. Tätä yhteyttä ei ole aiemmin tutkittu väestöpohjaisessa otoksessa. APA:n on myös havaittu olevan yksi skitsofrenian riskitekijöistä, mutta vaikutuksen suuruutta sairastumisriskiin, mahdollisia sukupuolieroja, kliinisiä piirteitä tai yhteyttä kuvantamislöydöksiin ei tunneta. Tämän tutkimuksen tarkoitus oli selvittää APA:n vaikutusta lasten skitsofreniariskiin ja kuolleisuuteen. Pohjois-Suomen vuoden 1966 syntymäkohortti (Northern Finland 1966 Birth Cohort, NFBC 1966) käsittää 12 068 raskaana olevaa naista ja heidän 12 058 elävänä syntynyttä lastaan. Tässä tutkimuksessa käytetty tieto on kerätty prospektiivisesti 11 058 kohortin jäsenestä, jotka asuivat Suomessa yhden vuoden ikäisinä eivätkä olleet kaksosia. Helsingin vuosien 1951–1960 skitsofreniakohortin 529 Helsingissä 1951–1960 syntynyttä jäsentä seurattiin tätä tutkimusta varten prospektiivisesti kesäkuuhun 2006 asti. Suomalaiseen psykoosikohorttiin (The Finnish Nonaffective Psychosis Cohort, Finnish NAP Cohort) kuuluu 13 712 psykoosia sairastavaa henkilöä, jotka ovat syntyneet 1950–1969. Sekä isän korkea (≥30) että nuori ikä (<25) lisäsivät riskiä sairastua skitsofreniaan. Isän nuori ikä näytti lisäävän riskiä ainoastaan pojilla. Yleisväestössä isän korkea ikä oli yhteydessä lisääntyneeseen kokonaiskuolleisuuteen ja itsemurhiin naisilla, mutta vastaavaa yhteyttä ei havaittu miehillä. Psykoosia sairastavilla naisilla isän ikä ≥40 oli yhteydessä lisääntyneeseen kokonaiskuolleisuuteen ja luonnollisiin kuolemiin. Yleisväestössä ja psykoosia sairastavilla korkea isän ikä oli yhteydessä äidin skitsofreniaan. Skitsofreniaa sairastavilla korkea isän ikä liittyi pitempään hoitamattoman psykoosin kestoon, huonompaan sosiaaliseen ja ammatilliseen toimintakykyyn sekä lisääntyneeseen päihteiden käyttöön. Tämä tutkimus vahvisti aiempaa käsitystä isän korkean iän yhteydestä kuolleisuuteen ja skitsofreniaan. Löydöksellä on mahdollisia kansanterveydellisiä vaikutuksia, koska keskimääräinen isän ikä on noussut ja on yleistä väestössä. Isän ikään on mahdollista vaikuttaa. Isän ikä on myös mahdollinen sekoittava tekijä tutkittaessa skitsofrenian kausaalisia tekijöitä ja kehityskulkuja
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Lubczyńska, Małgorzata Joanna 1984. "Air pollution exposure, and child's neuropsychological and neurobiological development." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668730.
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Air pollution is a major public health concern, leading to worldwide morbidity and premature mortality. In the recent years, exposure to air pollution has also been linked to neurological and neuropsychological diseases, with fetuses and children identified as some of the most vulnerable populations. However, the evidence to date is still too limited to draw definitive conclusions. This thesis aimed to fill some of the existing knowledge gaps regarding the associations between fetal and childhood exposure to various air pollutants ubiquitous in urban areas, with neurological and neuropsychological alterations in children. To this aim, we used air pollution data collected within ESCAPE, TRANSPHORM, and MUSiC projects, and our study population consisted of children from various European prospective birth cohorts, with data available on the outcome of interest, as well as on child and parental socioeconomic, and life-style characteristics. Our results reinforced the notion that exposure to air pollution in the early years of life is harmful for children’s neurodevelopment.La contaminación del aire es un problema importante de salud pública que provoca morbilidad y mortalidad prematura en todo el mundo. En los últimos años, la exposición a la contaminación del aire también se ha relacionado con enfermedades neurológicas y neuropsicológicas, siendo los fetos y niños identificados como algunas de las poblaciones más vulnerables. Sin embargo, la evidencia es todavía demasiado limitada para extraer conclusiones definitivas. El objetivo de esta tesis fue completar algunas de las lagunas de conocimiento existentes sobre las relaciones entre la exposición durante la vida fetal y la infancia a diversos contaminantes del aire en áreas urbanas, con alteraciones neurológicas y neuropsicológicas en niños. Para este objetivo, utilizamos los datos de contaminación del aire recogidos dentro de proyectos ESCAPE, TRANSPHORM, y MUSiC, y nuestra población de estudio consistió en niños de varias cohortes de nacimientos europeos, con datos disponibles sobre el resultado de salud de interés, así como en aspectos socioeconómicos y las características de estilo de vida de los niños y sus padres. Nuestros resultados reforzaron la noción de que la exposición a la contaminación del aire en los primeros años de vida es perjudicial para el desarrollo neurológico de los niños.
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Vogt, Hartmut. "Early life factors and the long-term development of asthma." Doctoral thesis, Linköpings universitet, Pediatrik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85159.
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Asthma, a huge burden on millions of individuals worldwide, is one of the most important public health issues in many countries. As genetic and environmental factors interact, asthma may be programmed very early in life, perhaps even in utero. The aim of this thesis was to assess the impact of gestational age, cord blood immunoglobulin E (IgE), a family history of asthma, migration, and pertussis immunization in early life on the development of asthma in child and adult populations. As a proxy for asthma disease, dispensed asthma medication was used as the main outcome variable based on data from the Swedish Prescribed Drug Register. Data from other national registers were used to control for confounders. Three of our studies were based on national cohorts, and one on a local birth cohort that was initiated in 1974–75. Gestational age had an inverse dose-response relationship with dispensed asthma medication in 6– to 19-year-olds. Odds ratios for dispensed asthma medication increased with degree of prematurity compared with children born in term. Furthermore, asthma medication was more likely to be dispensed among children and adolescents born early term after 37–38 weeks’ gestation than among those at the same age who were born in term. Elevated cord blood IgE and a family history of asthma in infancy were associated with a two- to threefold increased likelihood of dispensed asthma medication and self-reported allergen-induced respiratory symptoms at the age of 32–34 years, but the predictive power was poor. Age at migration had an inverse dose-response relationship with dispensed asthma medication at the age of 6–25 years in adoptees and foreign-born children with foreign-born parents. International adoptees and children born in Sweden to foreign-born parents had three- to fourfold higher rates of asthma medication compared with foreign-born children who were raised by their foreign-born birth parents. No association was found between pertussis immunization in early infancy and dispensed asthma medication in 15-year-olds. The type of vaccine or vaccine schedule did not affect the outcome. Fetal life is a vulnerable period. This thesis strengthens the evidence that every week of gestation is important for lung maturation. Cord blood IgE, however, did not predict the risk of asthma in adults. Furthermore, the study of migrating populations demonstrated that environmental changes at any age during childhood may affect the risk of asthma. Another, important public health message from this thesis is that vaccination against pertussis in early childhood can be considered safe with respect to the long-term development of asthma.
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Chung, Sai-ho. "Statistical models for catch-at-length data with birth cohort information." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B39849089.
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Chung, Sai-ho, and 鍾世豪. "Statistical models for catch-at-length data with birth cohort information." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B39849089.
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Moilanen, K. (Kristiina). "Diagnostics and determinants of schizophrenia:the Northern Finland 1966 Birth Cohort Study." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514296123.
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Abstract The Northern Finland 1966 Birth Cohort is an unselected, population-based sample of 12,058 live born children. The present study is based on 10,934 individuals living in Finland at the age of 16 years. Ninety-six research diagnoses fulfilling operational DSM-III-R criteria for schizophrenia by age 34 years were found in the reassessment of clinical diagnoses. Of these 96 cases, 55 (57%) had concordant diagnoses (both the clinical and research diagnosis was schizophrenia) and 41 (43%) had discordant diagnoses (the clinical diagnosis was other than schizophrenia). Diagnostic discordance was associated with low parental social class in 1980, later age at onset, comorbid diagnosis of mental retardation, shorter treatment periods and lower number of treatment episodes. Unwanted pregnancy and parental history of psychosis increased the risk for schizophrenia. The combination of unwantedness of pregnancy and parental history of psychosis elevated the risk of schizophrenia over 8-fold in offspring compared to those without either risk factor. Both low and high birth weight increased the risk of later schizophrenia. Both short and tall babies also had elevated risk. A reverse J-shape curve described the associations between birth weight, length and schizophrenia. The ages when cohort members learned to stand, walk and became potty-trained were related to subsequent incidence of schizophrenia and other psychoses. Earlier milestones reduced and later milestones increased the risk in a linear manner. In conclusion, these results indicate that schizophrenia has complex phenomenology and developmental pathways. Its multiple symptomatology with no single specific defining feature and no absolute validation criteria makes the phenomenological-based diagnosis of schizophrenia challenging. Unwanted pregnancy may act as an additive factor for subjects already vulnerable to schizophrenia and psychoses may have a developmental dimension expressed as deviant foetal development and delayed milestones. These results support the neurodevelopmental theory suggesting that schizophrenia results from small developmental deviances with origins very early in developmentTiivistelmä Tämän tutkimuksen tavoitteena oli tutkia skitsofrenian diagnostiikan osuvuuteen liittyviä tekijöitä sekä raskauden ei-toivottavuuden, lapsen syntymäpainon ja -pituuden ja skitsofrenian sekä varhaislapsuuden kehityksen ja skitsofrenian ja muiden psykoosien välistä yhteyttä. Pohjois-Suomen vuoden 1966 syntymäkohortti on prospektiivinen, epidemiologinen seurantatutkimus, johon kuuluu 12,058 vuonna1966 syntynyttä lasta. Prospektiivista tietoa on kerätty raskaudesta alkaen elinolosuhteista, elintavoista ja perheestä ja perimästä. Tämä tutkimus perustuu 10,934 henkilöön, jotka ovat asuneet 16-vuotiaana Suomessa eivätkä ole kieltäneet tietojensa käyttämistä tutkimukseen. Kliinisten diagnoosien uudelleen arvioinnissa DSM-III-R:n kriteerit täyttäviä skitsofreniatapauksia 34 ikävuoteen mennessä todettiin 96. Näistä 96 tapauksesta myös 55:n (57 %) kliininen diagnoosi oli skitsofrenia ja 41:n (43 %) kliininen diagnoosi oli muu kuin skitsofrenia. Diagnostiikan epätarkkuus liittyi matalaan sosiaaliluokkaan vuonna 1980, myöhäiseen sairastumisikään, samanaikaiseen kehitysvamma-diagnoosiin, lyhyisiin hoitoaikoihin ja vähäiseen hoitojaksojen määrään. Ei-toivottu raskaus yhdessä vanhemman psykoosisairauden kanssa lisäsi lapsen skitsofrenian riskiä yli 8-kertaiseksi. Matala ja korkea syntymäpaino lisäsivät skitsofrenian riskiä kaksinkertaiseksi ja samansuuruinen riskin kasvu havaittiin myös lapsilla, jotka olivat syntyessään lyhyitä tai pitkiä. J-muotoinen yhteys havaittiin syntymäpainon ja -pituuden sekä skitsofrenian riskin välillä. Ikä, jolloin lapsi oppi seisomaan, kävelemään ja kuivaksi, liittyi myöhempään skitsofreniaan ja sairastumiseen muihin psykooseihin. Varhainen oppiminen laski ja myöhäinen kehitys kohotti riskiä sairastua lineaarisesti. Tutkimuksen tulokset osoittivat, että skitsofrenia on monimuotoinen kliininen oireyhtymä, mikä tekee diagnostiikan haastavaksi. Raskauden ei-toivottavuus liittyneenä vanhemman psykoosisairauteen lisää lapsen skitsofrenian riskiä. Myös poikkeava syntymäpaino ja -pituus lisäävät skitsofrenian riskiä. Psykooseihin voi liittyä kehityksellinen dimensio, joka ilmenee viivästyneenä kehityksenä
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Berrington, Ann. "Partnership formation and dissolution in Britain : evidence from the 1958 birth cohort." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266523.
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Pinto, Elisabete Cristina Bastos. "Fetal growth and dietary intake during pregnancy: results of Porto birth cohort." Tese, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/23609.
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Melotti, Roberto. "Alcohol patterns through mid-adolescence and socioeconomic position : the ALSPAC birth-cohort." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702449.
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Socioeconomic inequalities of adolescent alcohol use are not as consistent as for other health risk behaviours. Thesis hypotheses were that a) alternative familial early socioeconomic position indicators of both immaterial and material resources presented specific associations with several modalities of alcohol consumption; b) associations of immaterial capital typically diluted from early to middle adolescence and material/immaterial influences varied between genders; and c) the socioeconomic context of schools exerted influence on middle adolescent alcohol misuse. Outcome data were collected at age 12, 13 and 15 from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth-cohort. Self-reported early alcohol onset, ever/past use, misuse and problem use were investigated in early and mid-adolescence. Socioeconomic position included mother's reported questionnaire-based measures of maternal education, parental social class and disposable household income. School level indicators were retrieved from Annual School Census data linked to ALSPAC. Multiple logistic regressions assessed associations between variables. Sensitivity analyses used multiple imputations. Multilevel models accounted for ALSPAC participants nested within schools. Maternal education was negatively associated with most measures of alcohol investigated, including early onset and use/misuse at both age 13 and 15. Conversely, household income had positive associations with measures of early alcohol use and later measures of alcohol misuse. Girls in more disadavantaged families were at lower risk of alcohol related problems than boys. However, for increasing levels of income and maternal education their risks overtook and matched that of boys, respectively. Non negligible residual variance of alcohol misuse among schools (~ to 3%) was not explained by the school socioeconomic context. Socioeconomic gradients on underage drinking manifest since early alcohol exposure and differ by construct through mid-adolescence. Policies on youth drinking should reflect that material advantage across the socioeconomic spectrum may increase risk of alcohol misuse and problem use, particularly in girls.
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Lankila, T. (Tiina). "Residential area and health:a study of the Northern Finland Birth Cohort 1966." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206660.
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Abstract Sparsely populated Finland is an interesting area for studying the effects of population density and distance on health. Previous studies indicate health problems in rural and remote areas. Aim is to study the importance of local residential area to health of young adults: how the residential area is associated with health, what is the role of geographical distance and how health is associated with moving. Study utilises the 31-year follow-up data from the Northern Finland Birth Cohort 1966 study, initially including all children born in the provinces of Oulu and Lapland in 1966. Local residential area is defined with 1 km² population density grid data. Distances to municipality centre or health centre are calculated using Finnish road network data (Digiroad). Perceived health in rural and urban areas is studied with ordinal logistic regression; body mass index (BMI) and overweight in relation to distance to municipality’s centre and population density using a generalised additive model. Role of distance in health centre use and distance-related inequity are studied with negative binomial regression and concentration indices, and health’s association with moving in multinomial logistic regressions. Poor perceived health increased from densely to sparsely populated areas. Among rural men adverse psychosocial and lifestyle factors were behind the associations, among women reasons for poor health in scattered settlement areas remained unclear. BMI and overweight increased at distances greater than 5 kilometres from municipality centre and with decreasing population density. No barrier effects of distance or distance-related inequity in the health centre use was found. Dissatisfaction with life and history of morbidity were associated with rural-urban moves, activity limiting illness with rural-rural moves, and frequent use of health services with all urban moves. Geographical distance was not a major barrier in health service use among young adults. Individual’s health status was linked with moving and may be relevant for rural-urban health inequalities. Local health variations within small administrative areas can be identified by grid-based data, indicating the need of customised interventions. Urban sprawl may affect people’s bodyweight, also urging health-based planning of residential areas. Longitudinal perspective would improve predictive value of findingsTiivistelmä Harvaan asuttu Suomi on kiinnostava alue väentiheyden ja etäisyyden terveysvaikutusten tutkimiselle. Aiempien tutkimusten mukaan maaseutumaisilla ja syrjäisillä alueilla on monia terveysongelmia. Tutkimuksen tarkoituksena on selvittää asuinympäristön merkitystä nuorten aikuisten terveydelle: miten asuinympäristö on yhteydessä terveyteen, mikä rooli etäisyydellä on ja miten terveys on yhteydessä muuttamiseen. Aineistona on Pohjois-Suomen syntymäkohortti 1966:n 31-vuotisseuranta-aineisto, sisältäen alkujaan kaikki vuonna 1966 Oulun ja Lapin läänissä syntyneet lapset. Asuinympäristö määritettiin 1 km2 väestöruutuaineiston avulla. Etäisyydet kunta- ja terveyskeskuksiin laskettiin Suomen tie- ja katuverkkotietokantaa (Digiroad) käyttäen. Koettua terveyttä tutkittiin maaseutu-kaupunkijatkumolla ordinaalisella logistisella regressiolla; painoindeksin (BMI) ja ylipainon yhteyttä kuntakeskusetäisyyteen ja väentiheyteen yleistetyllä additiivisella mallilla. Terveyspalvelujen käyttöä ja käytön oikeudenmukaisuutta etäisyyden suhteen tutkittiin negatiivisella binomiregressiolla ja konsentraatioindekseillä, ja terveyden yhteyttä muuttamiseen multinomiaalisella logistisella regressiolla. Huono koettu terveys lisääntyi kaupunkikeskustoista haja-asutusalueille. Maalla asuvien miesten huono koettu terveys selittyi psykososiaalisilla ja terveyskäyttäytymistekijöillä; naisilla syy huonoon koettuun terveyteen haja-asutusalueella jäi epäselväksi. BMI ja ylipainoisten osuus alkoivat kasvaa kuntakeskusetäisyyden ylittäessä viisi kilometriä ja väentiheyden vähetessä. Etäisyys ei vähentänyt terveyskeskuspalvelujen käyttöä, eikä etäisyyteen liittyvää epäoikeudenmukaisuutta havaittu. Elämään tyytymättömyys ja elämänaikainen sairastavuus olivat yhteydessä maaseutu-kaupunkimuuttoihin, haittaava sairastavuus maaseudun sisäisiin muuttoihin ja terveyspalvelujen käyttö kaikkiin kaupunkimuuttoihin. Maantieteellinen etäisyys ei estänyt nuorten aikuisten terveyspalvelujen käyttöä. Yksilön terveys oli yhteydessä muuttamiseen, millä voi olla merkitystä myös terveyden alue-eroille. Ruutuaineiston avulla voidaan löytää terveyseroja hallinnollisten alueiden sisältä, mikä kannustaa toimenpiteiden räätälöintiin eri alueille. Kaupunkirakenteen hajautuminen voi vaikuttaa yksilön painoon, joten terveysnäkökulma tulisi huomioida aluesuunnittelussa. Pitkittäinen tutkimusote parantaisi löydösten ennustavuutta
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Alaraudanjoki, V. (Viivi). "Erosive tooth wear and associated factors in Northern Finland Birth Cohort 1966." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217802.
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Abstract The aim of this study was to investigate the status of erosive tooth wear (ETW) in Finnish middle-aged adults and its association with dental caries and sociodemographic and intrinsic factors. In addition, we performed a genome-wide association study (GWAS) to identify whether genetic polymorphism (single nucleotide polymorphism) could explain some of the individual variance in the ETW status. Another aim of the study was to validate the use of the erosion index, the Basic Erosive Wear Examination (BEWE), on 3D models. Of the total Northern Finland Birth Cohort (NFBC1966), a convenience sample of 3,181 people was invited for an oral health examination in 2012–2013, of whom 1,962 participated, thus comprising the study group for the present study. ETW was assessed by sextants using the BEWE index. The clinical data was supplemented by information collected by means of postal questionnaires in 1997–1998 and 2012–2013, blood samples, and 3D models of the dentition. Of those clinically examined, 586 participants were randomly selected for the validation study of the BEWE index on 3D models. ETW was a common finding among the Finnish adult population, and almost half of the population needed at least preventive measures against the condition, and almost one in ten had severe ETW. Male gender and restorative treatment need due to dental caries were associated with ETW, unlike sociodemographic factors. Of the intrinsic factors, daily reflux symptoms and hyposalivation were the most significantly associated with severe ETW. According to the results from the GWAS, susceptibility to ETW could be partly explained by genetic polymorphism. The BEWE index was found reliable for recording ETW clinically and on 3D models, and 3D models were especially sensitive in detecting initial ETW. In conclusion, ETW seems to be common among Finnish adults, especially among males. In addition to risk factors, individual susceptibility should be kept in mind when assessing the risk for the condition. Early diagnosis of ETW is important in maintaining good oral health, and the BEWE seems to be a reliable index for that purpose both clinically and on 3D modelsTiivistelmä Tutkimuksen tavoitteena oli selvittää hampaiden erosiivisen kulumisen yleisyyttä ja vakavuutta suomalaisilla keski-ikäisillä aikuisilla, sekä erosiivisen kulumisen yhteyttä hampaiden reikiintymiseen sekä sosiodemografisiin ja sisäisiin tekijöihin. Lisäksi selvitettiin koko genomin kartoitusta hyödyntäen, voidaanko geneettisellä polymorfismilla (yksittäisillä emäsparin vaihdoksilla) selittää yksilön alttiutta erosiiviselle kulumiselle. Tutkimuksen tavoitteena oli myös validoida erosiivista kulumista arvioiva indeksi (The Basic Erosive Wear Examination, BEWE) 3D-malleilla. Koko Pohjois-Suomen vuoden 1966 syntymäkohortista kutsuttiin 3 181 henkilöä suun terveystarkastukseen vuosina 2012–2013. Kutsutuista 1 962 osallistui tutkimukseen muodostaen lopullisen tutkimusjoukon. Erosiivista kulumista arvioitiin käyttäen BEWE-indeksiä. Kliinistä tutkimusta täydensivät vuosina 1997–1998 ja 2012–2013 tehdyt postikyselyt, verinäytteet ja hampaiston 3D-mallit. Kliinisesti tutkituista osallistujista yhteensä 586 henkilöä valittiin satunnaisesti BEWE-indeksin validointitutkimukseen 3D-malleilla. Erosiivinen kuluminen oli yleistä suomalaisilla aikuisilla, ja lähes puolella oli erosiivista kulumista, joka vaatisi vähintään ennaltaehkäiseviä toimia. Vakavaa erosiivista kulumista on lähes joka kymmenennellä. Miessukupuoli ja korjaavan hoidon tarve hampaiden karioitumisen vuoksi olivat yhteydessä erosiiviseen kulumiseen, toisin kuin sosiodemografiset tekijät. Sisäisistä tekijöistä päivittäiset reflux-oireet ja vähäinen syljeneritys olivat vahvimmin yhteydessä vakavaan erosiiviseen kulumiseen. Koko genomikartoituksen perusteella vaikuttaa siltä, että alttius erosiiviselle kulumiselle saattaa selittyä osittain geneettisellä polymorfismilla. BEWE-indeksi näyttää olevan luotettava menetelmä niin kliinisessä arvioinnissa kuin arvioitaessa erosiivista kulumista 3D-malleilla. Alkava erosiivinen kuluminen oli helpommin havaittavissa 3D-malleilta kliiniseen arviointiin verrattuna. Tutkimuksen perusteella voidaan sanoa, että erosiivinen kuluminen on yleistä suomalaisilla aikuisilla, etenkin miehillä. Jo tiedettyjen riskitekijöiden lisäksi yksilöllinen alttius erosiiviselle kulumiselle tulisi pitää mielessä riskikartoitusta tehdessä. Erosiivisen kulumisen aikainen diagnosointi on tärkeää hyvän suun terveyden ylläpitämiseksi, ja BEWE-indeksi vaikuttaa soveltuvan diagnosointiin niin kliinisesti kuin 3D malleillakin
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Pinto, Elisabete Cristina Bastos. "Fetal growth and dietary intake during pregnancy: results of Porto birth cohort." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/23609.
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Reynaud, Eve. "Étude des réveils nocturnes et du comportement de l’enfant de 2 à 5 ans dans la cohorte EDEN : une approche développementale." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB108/document.
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Contexte : La structure du sommeil évolue grandement dans les premières années de vie. Les réveils nocturnes occasionnels chez les enfants d'âge préscolaire font partie d’un processus normal de développement et de maturation du sommeil. Ils sont cependant considérés comme anormalement fréquents lorsqu’ils surviennent une nuit sur deux ou plus. La littérature suggère que les réveils nocturnes fréquents sont associés de manière transversale à des difficultés comportementales du jeune enfant. Or, l’évolution des réveils nocturnes dans la petite enfance, les facteurs associés à leurs trajectoires et les liens longitudinaux avec le comportement sont peu connus. Objectifs : Modéliser l’évolution des réveils nocturnes entre l’âge de 2 et 5-6 ans et explorer leurs liens avec des facteurs précoces familiaux et de l’enfant. Analyser les associations entre les trajectoires de réveils nocturnes et le comportement de l’enfant avant l’entrée à l’école. Population et méthode : Nos analyses ont porté sur les données de l’étude EDEN. Il s’agit d’une cohorte mère enfant, qui a recruté 2 002 femmes enceintes entre 2003 et 2006 dans les maternités de Nancy et Poitiers. Les réveils nocturnes et le comportement ont été mesurés par des questionnaires parentaux à l’âge de 2, 3 et 5-6 ans. La méthode du « group-based trajectory modeling » nous a permis de modéliser l’évolution des réveils nocturnes et de difficultés d’attention, et ainsi d’identifier des trajectoires, décrivant différentes histoires développementales entre l’âge de 2 et 5-6 ans. Les analyses statistiques pour mesurer les associations entre les trajectoires de réveils nocturnes, les facteurs précoces et le comportement de l’enfant, ont été faites par régressions logistiques, ajustées sur les facteurs de confusion potentiels. Résultats : Deux trajectoires distinctes de réveils nocturnes ont été identifiées chez les enfants entre 2 et 5-6 ans. L’une, nommée “réveils nocturnes rares”, représentait 77% des enfants. Ce groupe suivait une trajectoire linéaire proche de zéro et légèrement décroissante avec le temps. La seconde trajectoire, nommée « réveils nocturnes communs », représentait 23% des enfants. Elle était plus haute que la première trajectoire à chaque point de suivi, et présentait un pic à l’âge de 3 ans. Les facteurs de risque d’appartenir à la trajectoire de « réveils nocturnes communs » étaient essentiellement environnementaux : l’exposition au tabagisme passif, un mode de garde collectif et le temps passé devant la télévision. Les enfants appartenant à la trajectoire de réveils nocturnes communs présentent un risque accru de présenter des symptômes émotionnels, des problèmes de conduite et des problèmes d'hyperactivité/inattention à l’âge de 5-6 ans. Aucune association n'a été trouvée avec le comportement pro-social ou avec les problèmes de relations avec les pairs. Trois trajectoires d’inattention/hyperactivité ont été identifiées, une trajectoire basse, intermédiaire et une haute, toutes trois stables au cours du temps. Le risque d’appartenir à une trajectoire haute d’inattention/hyperactivité, par rapport à une trajectoire basse, était quatre fois plus important pour les enfants avec une trajectoire de « réveils nocturnes communs » comparativement à ceux avec trajectoire de « réveils nocturnes rares ». Conclusion : Les réveils nocturnes et les troubles d’inattention/hyperactivité persistent dans la petite enfance. Une trajectoire de réveils nocturnes communs durant cette période est un facteur de risque de plusieurs troubles du comportement : symptôme émotionnel, troubles de conduites et inattention/hyperactivité. Ces derniers co-évoluent avec les troubles du sommeil. Nos résultats soulignent l’importance d’identifier et de prendre en charge les difficultés de sommeil dès le plus jeune âge, surtout en présence de difficultés de comportementContext: The structure of sleep evolves greatly in the first years of life. Occasional nightwaking is thus normal in young children, but waking-up every other night or more is considered adversely frequent. The scientific literature suggests that frequent night-waking is associated with concomitant behavioral difficulties in children. Yet, little is known about the evolution of night-waking in preschool years and its longitudinal association with behavior. Objectives: To model the evolution of night-waking between the age of 2 and 5-6 years and explore the association with family and child related factors. To analyze the associations between night-waking trajectories and behavior before school entry. Population and methods: Analyses were based on the French birth-cohort study EDEN, which recruited 2 002 pregnant women between 2003 and 2006 in the maternity of Poitiers and Nancy. Information regarding night-waking and behavior were assessed using parental questionnaires at the ages of 2, 3 and 5-6 years. The « group based trajectory modeling » method allowed us to model the evolution of night-waking and of inattention/hyperactivity, describing different developmental trends between the age of 2 and 5-6 years. The associations between night-waking trajectories, family and child related factors and behavior, were analyzed using logistic regressions, adjusted on potential confounding factors. Results: Two distinct night-waking trajectories were identified in children between the age of 2 and 5-6 years. One, named « rare night-waking », represented 77% of the children. This group followed a linear trajectory, which was close to zero and slightly declining with time. The second trajectory, named « common night-waking », represented 23% of the children. It was higher than the first trajectory at each time-point, and a peak was observed at age 3. Risk factors for belonging to the « common night-waking » trajectory were life-style related factors: exposures to second hand smoking, collective care arrangement, and time spent in front of the television. Children belonging to the common night-waking trajectory had higher risk of having emotional symptoms, conduct problems and inattention/hyperactivity at age 5-6. No associations were found with prosocial behavior nor peer-relationship problems. Three trajectories of inattention/hyperactivity were identified, a low, an intermediate and a high one, all stable in time. The risk of belonging to a high inattention/hyperactivity trajectory, compared to a low one, were four time more important for children with a « common night-waking » trajectory. Conclusion: Night-waking and inattention/hyperactivity persist in preschool years. A common night-waking trajectory during this period is a risk factor of diverse behavioral difficulties: emotional symptoms, conduct problems and inattention/hyperactivity. The latter co-evolves with night-waking. Our results highlight the importance of identifying sleep problems in early years, especially in the presence of behavioral difficulties
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Cavanah, Cassidy R. "Genre, Birth Cohort, and Product Perception: Responses to Background Music in Commercial Advertising." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/198.
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Research shows that music transmits both embodied (universally perceptible) and referential (culturally specific) meanings. The present study sought to explore the persuasive power of music in commercial advertising, and the complex ties that exist between music, life experience and perception. The study looked at how the perception of a product could be altered in accordance with specific embodied and referential meanings. With a focus on the effects of music genre and birth cohort on product perception, embodied meanings were expected to produce similar results across birth cohorts, and referential meanings were expected to produce significantly different results. A total of 100 participants were administered the survey online. Participants watched 30-second original video clips and were asked to complete a survey. There were 16 videos made with the 4 products types and 4 music genres selected for the experiment. The survey measured perception through ratings of agreement to statements; one set of statements aimed to measure embodied meaning and the other to measure referential meaning. Each measure of the survey was individually analyzed; data used here is from the analysis of a product as classic. There was a significant main effect of music genre on product perception for a majority of the measures, F(3,273)=13.075, p F (2,91)=3.941, p=.023. There was no significant interaction between birth cohort and music genre on product perception for any measures, F(6,273)=.801, p =.570. Results show that the older cohort prefers classic rock and jazz, the younger birth cohort prefers electronic and pop. Results for the questions looking at referential meaning primarily produced insignificant results.
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Desmond, Katharine J. (Katharine Joanna) 1949. "Traffic injuries in children : a secondary analysis of the 1958 British birth cohort." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61732.
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Chow, Wing-shan Claudia. "Maternal exposure to environmental tobacco smoke and birth weight a retrospective cohort study /." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31970989.
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Deverell, Marie. "Risk factors for persistent asthma in adolescents : a community based longitudinal birth cohort." University of Western Australia. School of Paediatrics and Child Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0171.
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[Truncated abstract] Asthma is a chronic and complex disorder and despite our increase in the understanding of the genetics, pathology and mechanisms underlying asthma a gold standard definition of asthma does not exist. A criterion for recognising and diagnosing asthma in epidemiological studies is crucial in order to determine risk factors for disease. Prospective longitudinal birth cohort studies have increased our understanding of the natural history and risk factors for asthma, yet we are still not able to accurately predict which children will go on to have asthma as adults. It is during the transition from childhood to adolescence where factors underlying asthma change and the prevalence of asthma shifts between the sexes. There are inconsistencies regarding risk factors for the development and persistence of disease during this transitional period. Risk factors predicting the development and persistence of asthma and intermediate phenotypes (BHR, airway inflammation and atopy) may be influenced by gender and risk factors predicting disease may differ between childhood and adolescence. Aims 1. To identify risk factors for Asthma, BHR and Atopy at 14yrs of age. 2. To determine risk factors for persistence of asthma between 6 and 14 years. 3. To examine the influence of gender on risk factors during adolescence. Method The West Australian Pregnancy Cohort is a longitudinal birth cohort. The cohort initially consisted of 2868 live births with follow-ups at 1, 2, 3, 6, 8, 10 and 14 years of V age. ... Strong associations were seen with BHR and new diagnosis of wheeze and asthma in VI teenagers. Interestingly having either a cat or dog inside was protective for persistence of disease; in particular stronger associations were seen in teenage girls not in boys. During this transitional period the risk factors for asthma and intermediate phenotypes differ between the sexes. Different mechanisms are likely to be involved in determining asthma in boys and girls during adolescence and shed new light on the recognised switch in the gender balance in asthma prevalence from the male predominance in childhood to the female predominance in adult life. Our understanding of the natural course of disease from the prenatal period to adulthood and the identification of the various asthma phenotypes has the potential to change prognosis and planning of therapeutic strategies. Identifying those at high risk for persistence of disease in the early stages of life will allow therapeutic interventions to be more appropriately targeted.
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Allin, Matthew. "The prevalence and significance of neurological abnormalities in a young premature birth cohort." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427640.
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周詠珊 and Wing-shan Claudia Chow. "Maternal exposure to environmental tobacco smoke and birth weight: a retrospective cohort study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31970989.
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Von, Fintel Dieter. "Rising unemployment in South Africa : an intertemporal analysis using a Birth Cohort Panel." Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/3308.
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Thesis (MComm (Economics))--University of Stellenbosch, 2007.A new political dispensation in 1994 heralded a period of optimism for many ordinary South Africans, who hoped for freedom and an escape from poverty. Since this transition, however, South Africa has registered steady increases in unemployment, which was already high and widespread at that stage. The new policy environment introduced a mix of legislation which changed the way in which South African society was to be structured: separate development was abandoned, the pillars of Apartheid dismantled, and equitable access to education and jobs was enacted. At the same time, the Reconstruction and Development Programme (RDP), as well as the Growth Employment and Redistribution (GEAR) document addressed, amongst other issues, socioeconomic and labour market disparities. Economic growth was to bolster employment generation. Rising unemployment is, in light of these diverse changes, a source of considerable concern to labour market participants and policymakers alike: the benefits of better understanding the dynamic forces at play are potentially large. Given the many and farreaching changes referred to above, it is a complex task to disentangle specific reasons for the outcomes realised in the labour market, and more so the manner in which these have interacted to arrive at the status quo...
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Lee, Sue Jean. "The seasonality of preterm birth in a British cohort : a time-series investigation." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420467.
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Raza, Abid. "Epidemiology of adolescent asthma : risk and prognosis in a birth cohort over adolescence." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/376796/.
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Koen, Nastassja. "Psychological trauma and posttraumatic stress disorder in a South African birth cohort study." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/20264.
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Psychological trauma - including exposure to intimate partner violence (IPV) - is highly prevalent in South Africa, and may result in posttraumatic stress disorder (PTSD) in a subset of individuals. Pregnant women and new mothers are particularly vulnerable; and trauma exposure and PTSD in this sub-group may be associated with a number of adverse maternal-child sequelae including poor birth outcomes and impaired infant neurodevelopment. Risk factors for psychological trauma exposure, and for subsequent PTSD, are likely to include environmental and genetic influences. Given the high burden of trauma and related disorders, the unique genetic ancestry, and the relative paucity of empirical data, further work in South African populations is warranted. This thesis aimed to investigate a number of questions about trauma and PTSD in the Drakenstein Child Health Study (an ongoing South African birth cohort study), including their risk factors, their impact on infant birth anthropometry and development, and their genetic correlations. This thesis includes five publications, all presenting data from the Drakenstein Child Health Study. Pregnant women were recruited from two clinics in the Drakenstein sub-district - a peri-urban community outside Cape Town, Western Cape. Sociodemographic characteristics; psychosocial risk factors (including depression, stressful life events, psychological distress and alcohol and substance misuse); trauma exposure (childhood trauma, IPV and lifetime trauma); and PTSD were assessed using validated and reliable self-reported questionnaires, as well as diagnostic psychiatric interviews.
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Rissanen, I. (Ina). "Nervous system medications and suicidal ideation and behaviour:the Northern Finland Birth Cohort 1966." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526208077.
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Abstract The aim of this thesis was to explore the associations between the use of nervous system medications and suicidal ideation and behaviour in various different diagnostic groups in a large population-based cohort. Information on prescribed antipsychotic, antidepressant, benzodiazepine and antiepileptic medications within the Northern Finland Birth Cohort 1966 was collected from the register of the Social Insurance Institution of Finland and from a postal questionnaire sent to all cohort members in 1997. The presence of suicidal ideation and depression and anxiety symptoms was assessed via the Hopkins Symptom Checklist-25 questionnaire in 1997. Data on suicides were collected from the cause-of-death statistics and on suicide attempts from the Finnish Care Register for Health Care in a 15-year follow up. The use of antipsychotic, antidepressant, or benzodiazepine medication was associated with increased suicidal ideation, suicide attempts, and suicides. Antiepileptic medication was not associated with increased suicidality. The polypharmacy of nervous system medications was associated with increased suicidality. All nervous system medications were associated with increased severity of depression and anxiety symptoms. When depression and anxiety symptoms were taken into account, most of the associations between medication and suicidal ideation were statistically non-significant. Regarding specific groups, among those who did not have psychosis, high doses of antipsychotic medication correlated particularly with increased suicidal ideation even when other symptoms of depression and anxiety were taken into account. Among those with insomnia, the use of antidepressant medication associated with increased suicidal ideation also when other symptoms were taken into account. Although nervous system medication is associated with increased suicidal ideation, the association with other symptoms is also strong, and therefore it could not be stated that medication associates specifically with suicidal ideation. However, certain groups, i.e., non-psychotic subjects with high doses of antipsychotic medication, or subjects with insomnia and using antidepressant medication, should be closely monitored as they could be more vulnerable to suicidal ideationTiivistelmä Tämän väitöstutkimuksen tarkoituksena oli tutkia hermostoon vaikuttavien lääkkeiden, lähinnä psykoosilääkkeiden, masennuslääkkeiden, bentsodiatsepiinien sekä epilepsialääkkeiden, yhteyttä itsetuhoisiin ajatuksiin, itsemurhayrityksiin ja itsemurhiin. Aihetta tutkittiin eri diagnoosiluokissa suuressa väestöaineistossa, Pohjois-Suomen vuoden 1966 syntymäkohortissa. Tieto tutkimushenkilöiden lääkkeenkäytöstä vuodelta 1997 kerättiin Kelan lääkeostorekisteristä sekä postikyselyn avulla. Itsetuhoisten ajatusten ja muiden masennus- ja ahdistusoireiden vakavuutta mitattiin Hopkins Symptom Checklist-25 -kyselyn avulla vuonna 1997. Tieto itsemurhista kerättiin 15 vuoden seurannassa kuolinsyyrekisteristä ja tieto itsemurhayrityksistä hoitoilmoitusrekisteristä. Psykoosilääkkeiden, masennuslääkkeiden ja bentsodiatsepiinien käyttö oli yhteydessä lisääntyneisiin itsetuhoisiin ajatuksiin, itsemurhayrityksiin ja itsemurhiin. Epilepsialääkkeet eivät liittyneet itsetuhoisuuteen. Usean hermostoon vaikuttavan lääkkeen yhtäaikainen käyttö oli yhteydessä lisääntyneeseen itsetuhoisuuteen. Kaikki hermostoon vaikuttavat lääkkeet liittyivät lisääntyneisiin masennus- ja ahdistusoireisiin. Kun lääkityksen yhteys masennus- ja ahdistusoireisiin otettiin huomioon, lääkkeet eivät olleet erityisesti yhteydessä itsetuhoisiin ajatuksiin. Diagnostisten ryhmien välillä ei ollut eroa hermostoon vaikuttavien lääkkeiden ja itsemurhayritysten tai itsemurhien välisessä yhteydessä. Henkilöillä, joilla ei ole psykoosia, suuremmat psykoosilääkeannokset olivat yhteydessä itsetuhoisten ajatusten vakavuuteen kun muiden masennus- ja ahdistusoireiden vakavuus otettiin huomioon. Unettomuudesta kärsivillä henkilöillä masennuslääkkeen käyttö oli liittyi lisääntyneisiin itsetuhoisiin ajatuksiin kun muut oireet huomioitiin. Hermostoon vaikuttavat lääkkeet ovat yhteydessä lisääntyneisiin itsetuhoisiin ajatuksiin, mutta ne ovat myös vahvasti yhteydessä muihin masennus- ja ahdistusoireisiin. Tietyt henkilöt voivat kuitenkin olla erityisen herkkiä nimenomaan itsetuhoisille ajatuksille, ja heitä tulisi seurata erityisen tiiviisti. Tällaisia ovat henkilöt, joilla ei ole psykoosia, mutta jotka käyttävät suuria psykoosilääkeannoksia, sekä vakavasta unettomuudesta kärsivät henkilöt, jotka käyttävät masennuslääkettä
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Juola, P. (Pauliina). "Outcomes and their predictors in schizophrenia in the Northern Finland Birth Cohort 1966." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207728.
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Abstract The aim of this dissertation was to study outcomes in schizophrenia and their predictors in a meta-analysis and in the Northern Finland Birth Cohort 1966 (NFBC 1966). The NFBC 1966 is an unselected, population-based cohort consisting of 12,068 pregnant women and their 12,058 live-born children. This dissertation utilises data that has been collected from medical records, national registers and from two extensive psychiatric studies conducted when the cohort members were 34 and 43 years old, including interview, neurocognitive and brain magnetic resonance imaging data, and questionnaires. Depending on the topic investigated, the sample size ranges between 43 and 103 individuals with schizophrenia. The meta-analysis found that approximately 13.5% of subjects with schizophrenia recovered both clinically and socially, and the recovery rate has not increased in recent decades. Studies from countries with poorer economic indices had higher recovery estimates. In the NFBC 1966, individuals with schizophrenia who were young and single at illness onset, who experienced an insidious onset, and who had more hospital treatment days early on, were at greater risk of a poor outcome in terms of later psychiatric hospitalisations and lack of remission. A novel finding was an association between suicidal ideations at onset and higher number of later psychiatric hospitalisations. Associations were detected between decreased gray matter density in the left frontal and limbic areas and decreased total white matter volume, and concurrent poor outcomes at 34 years. Concerning neurocognitive functioning at 34 years, better long-term verbal memory predicted a better global outcome (symptoms, hospital treatments, social relationships and working combined) and better visual memory predicted a better vocational outcome nine years later. The results of this study show that recovery is possible, but not very common in schizophrenia. Though outcomes are relatively difficult to predict, many clinically relevant predictors were observed that can be used in predicting outcome in a nearly 20-year follow-up. However, more research is needed in order to explore predictors that could possibly be modified via early interventions so as to enhance outcomesTiivistelmä Tämän väitöstutkimuksen tarkoituksena oli tutkia skitsofrenian ennustetta ja ennustetekijöitä meta-analyysin ja Pohjois-Suomen vuoden 1966 syntymäkohortin avulla. Pohjois-Suomen vuoden 1966 syntymäkohortti on valikoitumaton, yleisväestöpohjainen kohortti, johon kuuluu 12 068 raskaana olevaa naista ja heidän 12 058 elävänä syntynyttä lastaan. Tässä väitöstutkimuksessa hyödynnetiin sairauskertomuksia, kansallisia rekistereitä sekä kahdessa laajassa kenttätutkimuksessa (34- ja 43-vuotistutkimukset) kerättyjä tietoja, jotka koostuvat haastatteluista, useista kyselyistä, neuropsykologisesta tutkimuksesta sekä aivojen magneettikuvauksesta. Tutkimuksen aiheesta riippuen aineiston koko eri osajulkaisuissa vaihteli 43:n ja 103:n välillä. Meta-analyysin perusteella 13,5 % skitsofreniaa sairastavista toipuu sekä kliinisesti että sosiaalisesti, eikä toipuminen ole viime vuosikymmeninä yleistynyt. Toipuneiden osuus oli suurempi köyhissä maissa. Pohjois-Suomen vuoden 1966 syntymäkohorttitutkimuksissa todettiin, että huonompi ennuste myöhempien sairaalahoitojen ja remission suhteen oli niillä, jotka olivat sairastuessaan nuoria ja naimattomia, joiden psykoosisairaus alkoi hitaasti ja joilla oli sairauden alkuvaiheissa enemmän sairaalahoitoja. Uusi löydös oli yhteys itsetuhoisten ajatusten ja myöhempien sairaalahoitojen välillä. Tiettyjen aivoalueiden tilavuuden ja rakenteen muutokset liittyivät monella tavoin samanhetkiseen taudinkuvaan 34-vuotiaana. Neurokognitiivisessa testauksessa parempi viivästetty kielellinen muisti 34-vuotiaana ennusti parempaa kokonaisvaltaista vointia (oireet, sairaalahoidot, sosiaaliset suhteet ja työssäkäynti yhdistettynä) ja parempi näönvarainen muisti ennusti työssäoloa 9 vuoden seurannassa. Tämän väitöstutkimuksen tulokset osoittavat, että skitsofreniasta toipuminen on mahdollista, vaikkakaan ei kovin yleistä. Vaikka taudinkulun ennustaminen on haastavaa, tutkimuksessa havaittiin useita kliinisesti merkittäviä tekijöitä, joilla on ennustearvoa jopa 20 vuoden seurannassa. Lisätutkimuksia kuitenkin tarvitaan, jotta löydettäisiin sellaisia ennustetekijöitä, joihin kohdistuvalla varhaisella interventiolla voitaisiin parantaa skitsofrenian ennustetta
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Timonen, M. (Markku). "The association between atopic disorders and depression:the Northern Finland 1966 Birth Cohort Study." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271556.
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Abstract
An excess of atopic allergies has been found in patients with depression, and conversely, increased amounts of depressive symptoms have been reported in patients with atopic disorders. Thus far, however, the findings have mainly been based on clinical samples. In this thesis, the association between atopic disorders and depression was investigated at epidemiological level by using data from the Northern Finland 1966 Birth Cohort.
An unselected cohort of 12058 liveborn children was followed prospectively from prenatal stages until 1997. During the 31-year follow-up, 6025 cohort members underwent skin prick tests. Data on lifetime depression diagnoses and atopic conditions were obtained from postal questionnaires and Finnish Hospital Discharge Registers, and the severity of the depressive symptoms was assessed with Hopkins Symptom Checklist-25. Information on the family histories of the atopic disorders was obtained from questionnaires of the 31-year follow-up.
Females with positive skin prick test responses and self-reported histories of allergic symptoms exhibited a 2.7-fold probability of developing lifetime depression. The corresponding probability increased in line with the increased severity of depressive symptoms in atopic but not in non-atopic females, ranging from 3.0 to 4.7-fold. Among males, the atopy-depression association was seen only in the highest depression scores, the odds ratio being up to 6.3-fold. While the most severe, hospital-treated manifestations of both disorders were considered, atopic disorders increased the risk of depression 3-fold independently of the subject's gender and sociodemographic characteristics. When investigating the effect of familial atopy on a child's depression, maternal atopy increased the probability of lifetime depression nearly 2-fold in females, and over 4-fold, when a female cohort member's own atopy was also present.
At epidemiological level, the presence of atopic conditions seemed to increase the probability of lifetime depression especially in females. Since both atopic disorders and depression are illnesses of major public health importance in Western countries, also the co-morbidity between these disorders should be seriously taken into account in clinical practice. Further investigations are called for in evaluating whether this association is specific to atopic disorders, since increased risks of depression have been noted in connection with many other physical diseases as well.
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Sbihi, Hind. "Childhood asthma and allergies in birth cohort studies : tools for environmental exposure assessment." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54046.
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Pediatric asthma and allergies represent global health problems causing substantial disability. Epidemiological research has established a link between air pollution and exacerbation of asthma. However, the role of air pollutants in relation to atopy and on the development of asthma is unclear.
This thesis examines the relationship between traffic-related air pollution and the development of atopy and asthma using two complementary Canadian birth cohorts where the impact of different exposure assessment approaches on observed associations was evaluated. Hopanes in house dust, collected in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study, were evaluated as markers of indoor infiltrated traffic-related air pollution by measuring their correlation with geographic predictors of outdoor concentrations of nitrogen dioxide. This correlation was dependent on the inclusion of behavioral characteristics, hindering the utility of measuring hopanes in settled dust for exposure assessment. As an alternative approach to assess exposures in CHILD, city-specific land use regression models, questionnaires and home assessments were used to model personal exposure, including accounting for indoor/outdoor infiltration and time-activity patterns, in relation to early atopy. Spatio-temporally adjusted exposure in the first year of life was positively associated with sensitization to common food or inhalant allergens at age 1 (Odds ratio [95% confidence interval] per interquartile increase in nitrogen dioxide = 1.16 [1.00 – 1.41]). Because atopy is often a precursor for allergic asthma, 10 years of longitudinal data from the Border Air Quality Study population-based birth cohort were used to evaluate the role of air pollution on asthma development. An interquartile range increase in nitrogen dioxide, adjusted for temporal and spatial variability, increased incident asthma among preschool (age 0-5) children by 9% (95% confidence interval: 4 – 13%). Surrounding residential greenness mitigated this effect. In further analysis, the course of asthma was found to follow three trajectories: transient asthma, early-, and late-infancy chronic asthma, the latter two being significantly associated with fine particulate matter and nitrogen dioxide. This dissertation highlights the importance of integrating temporal and spatial variation in traffic-related air pollution exposure assessment and clarifies the role of early exposures on atopy and asthma initiation.Medicine, Faculty of
Population and Public Health (SPPH), School of
Graduate