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1

Rehan Khan, Muhammad, Tayyaba Mushtaq Khan, Syed Munim Hussain, and Syed Mukarram Hussain. "Accuracy of Bisap Score to Predict Severe Acute Pancreatitis Keeping Ranson Score as Gold Standard." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 3426–28. http://dx.doi.org/10.53350/pjmhs2115103426.

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Objective: To ascertain the diagnostic accuracy of BISAP score to predict severe acute pancreatitis keeping Ranson score as gold standard Study design: Descriptive Cross Sectional study Place and duration of study: Surgical Department, Combined Military Hospital Rawalpindi from January 2017 to July 2017. Methodology: 65 patients having history indicative of acute pancreatitis, serum lipase and serum amylase were measured. Patients with confirmed diagnosis of acute pancreatitis who consented for taking part in the research and achieving the inclusion and exclusion criteria were enrolled for study. Patients were evaluated by adequate history and thorough examination. All patients are investigated for Ranson score and BISAP score and divided into mild and severe pancreatitis on the basis of BISAPS and Ranson scoring. Results: In our study, mean+sd age was 44.92+8.92 years. Frequency of severe acute pancreatitis was 32.3%. Diagnostic accuracy of BISAP score to predict severe acute pancreatitis keeping Ranson score as gold standard had 80.9% of sensitivity, 81% of specificity, 68% of PPV and 90% of NPV. Conclusion: BISAP score have an excellent accuracy for prediction of severe acute pancreatitis as Ranson score. BISAP score can be used as tool for recognition of severe acute pancreatitis within 24 hours in simple and precise manner. Keywords: Severe acute pancreatitis, Prediction, BISAP score, Ranson score, Accuracy
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2

V., Haridas T., and Asif Iqbal I. K. "A prospective study of the bedside index for severity in acute pancreatitis (BISAP) score in predicting severity and prognosis of acute pancreatitis." International Surgery Journal 6, no. 2 (2019): 570. http://dx.doi.org/10.18203/2349-2902.isj20190405.

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Background: The aim of this study was to evaluate the ability of Bedside Index for Severity in Acute Pancreatitis (BISAP) score in predicting the severity and prognosis in patients admitted with acute pancreatitis.Methods: A prospective study was performed on 52 patients who presented with acute pancreatitis during the study period between January 2016 to November 2016. BISAP score was calculated for the patients. The disease was classified as mild or severe on the basis of presence of organ system failure and local/systemic complications. The accuracy of BISAP score in predicting the severity and prognosis of acute pancreatitis was evaluated.Results: Of the 52 patients studied, 11 patients had BISAP ≥2 and 41 patients had BISAP score <2. 9 of the 11 patients who had BISAP score ≥2 developed severe pancreatitis, local or systemic complications and had poor prognosis. 37 of the 41 patients who had BISAP score < 2 developed mild pancreatitis.Conclusions: BISAP score is accurate in predicting severity and prognosis of acute pancreatitis. Patients with BISAP score ≥2 developed severe pancreatitis and carried poor prognosis than patients with BISAP score <2.
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3

Lu, Fei, Yan Zhang, Jing Yu, Zhenming Ge, and Liugen Gu. "Clinical value of BISAP score combined with CRP and NLR in evaluating the severity of acute pancreatitis." Medicine 102, no. 45 (2023): e35934. http://dx.doi.org/10.1097/md.0000000000035934.

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To investigate the clinical value of bedside index for severity in acute pancreatitis (BISAP) score combined with serum C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) in predicting the severity of early acute pancreatitis. A total of 113 patients with acute pancreatitis admitted to the Department of Gastroenterology, Second Affiliated Hospital of Nantong University from September 2019 to September 2022 were retrospectively collected and divided into mild acute pancreatitis group (51 cases), moderately severe acute pancreatitis group (32 cases) and severe acute pancreatitis group (30 cases) according to the severity of the disease. The general clinical data, laboratory test indicators, and imaging data within 72 hours were collected and compared among the 3 groups. The sensitivity, specificity, and accuracy of BISAP score, BISAP combined with CRP, BISAP combined with NLR, and BISAP combined with CRP and NLR in predicting the severity of acute pancreatitis were analyzed by receiver operating characteristic curve. 1. BISAP score (0.9608 ± 0.1119, 1.688 ± 0.1225, 2.6 ± 0.1135), CRP (74.77 ± 8.336, 142.9 ± 11.44, 187.6 ± 13.04), and NLR (8.063 ± 0.7781, 13.69 ± 1.023, 18.06 ± 1.685) increased sequentially in mild acute pancreatitis group, moderately severe acute pancreatitis group, and severe acute pancreatitis group, and the differences in BISAP score, CRP and NLR among the 3 groups were statistically significant (P < .05). BISAP score was positively correlated with CRP and NLR (R = 0.5062, 0.5247, P < .05). The area under the receiver operating characteristic curve of BISAP score, CRP, NLR, BISAP combined with NLR, and BISAP combined with CRP in predicting the severity of acute pancreatitis were 0.885, 0.814, 0.714, 0.953, respectively. The specificity and sensitivity of combined diagnosis were higher than those of BISAP score or CRP and NLR alone. BISAP score combined with CRP and NLR can effectively evaluate the severity of acute pancreatitis, and their combination has a higher predictive value for early severity assessment.
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4

Shahid, Dr Mohammad. "Comparative Study Of BISAP Score With APACHE-II Scoring System To Determine The Severity Of Acute Pancreatitis." IOSR Journal of Dental and Medical Sciences 23, no. 11 (2024): 06–11. http://dx.doi.org/10.9790/0853-2311020611.

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Introduction: Acute pancreatitis (AP) is a significant abdominal emergency characterized by inflammation of the pancreas, primarily due to autodigestion by pancreatic enzymes. Early severity assessment is crucial for management, as severe cases lead to complications and mortality. While various scoring systems exist, the Bedside Index for Severity in Acute Pancreatitis (BISAP) and APACHE-II (Acute Physiology and Chronic Health Evaluation) scores are commonly used, each with unique advantages and limitations in severity prediction. Objective: This study aims to compare the effectiveness of BISAP and APACHE-II scores in predicting acute pancreatitis severity, helping clinicians optimize treatment decisions. Methods: This observational study was conducted at SMS Hospital, Jaipur, involving 76 patients diagnosed with AP based on clinical, biochemical, and imaging criteria. Participants were assessed using both BISAP and APACHE-II scoring within 24 hours of admission, with a focus on accuracy in predicting severe cases and outcomes. Results: Among participants, the mean age was 43 years, and 84.2% were male. Gallstone disease was the leading cause of AP (55.2%), followed by alcohol (34.2%). BISAP scores ≥3 was associated with significantly higher mortality, highlighting BISAP’s predictive accuracy. The mean BISAP score was 1.86 ± 1.09, while the APACHE-II score was 6.97 ± 5.66, indicating more severe classifications using BISAP. The study found a moderate positive correlation between BISAP and APACHE-II scores, though only BISAP scores significantly predicted patient outcomes. Conclusion: BISAP offers a rapid and accurate assessment tool for AP severity, especially suitable for early intervention in high-risk patients. Compared to APACHE-II, BISAP is simpler, cost-effective, and demonstrates a high negative predictive value, making it more practical for acute settings.
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5

Karki, D., T. Tamang, D. Maharjan, P. Thapa, and S. Shrestha. "Comparison of BISAP score with Ranson’s score in predicting severe acute pancreatitis." Journal of Society of Surgeons of Nepal 18, no. 3 (2016): 44. http://dx.doi.org/10.3126/jssn.v18i3.15306.

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Objectives: To compare BISAP score with Ranson’s scoring in predicting severity of acute pancreatitisMethods: Extensive demographic, radiographic, and laboratory data from consecutive patients with AP admitted to our institution was collected between March 2014 to March 2015. Ranson’s and BISAP score was calculated. Severity of pancreatitis was defined according to Atlanta classification. Sensitivity, Specificity, PPV, NPV of both the scoring system was calculated and compared.Results: A total of 42 patients with diagnosis of acute pancreatitis were included during the study period. 21(50%) were male and 21(50%) were female. Mean age is 49.52 ± 17.37.Most common etiology was biliary (45%) followed by alcohol (31%). 20 (48%) patients were categorized as severe pancreatitis according to Atlanta classification. 21 (50%) patients had a Ranson’s score of ≥3 and 19 (45.24%) patients had a BISAP score of ≥3. Both Ranson’s and BISAP scoring system was statistically significant in determining SAP ( p-value = 0.002). Sensitivity, specificity, PPV and NPV of Ranson’s and BISAP score was calculated to be 75%, 72.72%, 71.43%, 76.19% and 70%, 77.27%, 73.68%, 73.91%. respectively. The AUC for SAP by Ranson’s score is 0.7386 ; 95%CI (0.602 - 0.874) and BISAP score is 0.7364 ; 95% CI ( 0.599 - 0.872).Conclusions: Both Ranson’s and BISAP scoring system is similar in predicting SAP. However BISAP has the advantage due to its simplicity.
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6

Zhu, Jianpeng, Linfei Wu, Yue Wang, Mengdie Fang, Qiang Liu, and Xiaofeng Zhang. "Predictive value of the Ranson and BISAP scoring systems for the severity and prognosis of acute pancreatitis: A systematic review and meta-analysis." PLOS ONE 19, no. 4 (2024): e0302046. http://dx.doi.org/10.1371/journal.pone.0302046.

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Background To systematically assess and compare the predictive value of the Ranson and Bedside Index of Severity in Acute Pancreatitis (BISAP) scoring systems for the severity and prognosis of acute pancreatitis (AP). Methods PubMed, Embase, Cochrane Library, and Web of Science were systematically searched until February 15, 2023. Outcomes in this analysis included severity and prognosis [mortality, organ failure, pancreatic necrosis, and intensive care unit (ICU) admission]. The revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was used to evaluate the quality of diagnostic accuracy studies. The threshold effect was evaluated for each outcome. The sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the summary receiver operating characteristic (SROC) curve (AUC) as well as 95% confidence intervals (CI) were calculated. The DeLong test was used for AUC comparisons. For the outcome evaluated by over 9 studies, publication bias was assessed using the Deeks’ funnel plot asymmetry test. Results Totally 17 studies of 5476 AP patients were included. For severity, the pooled sensitivity of the Ranson and BISAP was 0.95 (95%CI: 0.87, 0.98) and 0.67 (95%CI: 0.27, 0.92); the pooled specificity of the Ranson and BISAP was 0.74 (0.52, 0.88) and 0.95 (95%CI: 0.85, 0.98); the pooled AUC of the Ranson and BISAP was 0.95 (95%CI: 0.93, 0.97) and 0.94 (95%CI: 0.92, 0.96) (P = 0.480). For mortality, the pooled sensitivity of the Ranson and BISAP was 0.89 (95%CI: 0.73, 0.96) and 0.77 (95%CI: 0.58, 0.89); the pooled specificity of the Ranson and BISAP was 0.79 (95%CI: 0.68, 0.87) and 0.90 (95%CI: 0.86, 0.93); the pooled AUC of the Ranson and BISAP was 0.91 (95%CI: 0.88, 0.93) and 0.92 (95%CI: 0.90, 0.94) (P = 0.480). For organ failure, the pooled sensitivity of the Ranson and BISAP was 0.84 (95%CI: 0.76, 0.90) and 0.78 (95%CI: 0.60, 0.90); the pooled specificity of the Ranson and BISAP was 0.84 (95%CI: 0.63, 0.94) and 0.90 (95%CI: 0.72, 0.97); the pooled AUC of the Ranson and BISAP was 0.86 (95%CI: 0.82, 0.88) and 0.90 (95%CI: 0.87, 0.93) (P = 0.110). For pancreatic necrosis, the pooled sensitivity of the Ranson and BISAP was 0.63 (95%CI: 0.35, 0.84) and 0.63 (95%CI: 0.23, 0.90); the pooled specificity of the Ranson and BISAP was 0.90 (95%CI: 0.77, 0.96) and 0.93 (95%CI: 0.89, 0.96); the pooled AUC of the Ranson and BISAP was 0.87 (95%CI: 0.84, 0.90) and 0.93 (95%CI: 0.91, 0.95) (P = 0.001). For ICU admission, the pooled sensitivity of the Ranson and BISAP was 0.86 (95%CI: 0.77, 0.92) and 0.63 (95%CI: 0.52, 0.73); the pooled specificity of the Ranson and BISAP was 0.58 (95%CI: 0.55, 0.61) and 0.84 (95%CI: 0.81, 0.86); the pooled AUC of the Ranson and BISAP was 0.92 (95%CI: 0.81, 1.00) and 0.86 (95%CI: 0.67, 1.00) (P = 0.592). Conclusion The Ranson score was an applicable tool for predicting severity and prognosis of AP patients with reliable diagnostic accuracy in resource and time-limited settings. Future large-scale studies are needed to verify the findings.
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7

Bollamreddy, Lokesh, H. K. Tulasi Mohana Rao Ch, Nekkanty Ravi, S. Balagangadhara Rao M, Ranjan Nayak Samir, and Jaya Chandra T. "Study on Comparison between BISAP and Ransons Scores for Predicting Severe Acute Pancreatitis." International Journal of Toxicological and Pharmacological Research 14, no. 5 (2024): 131–33. https://doi.org/10.5281/zenodo.12787614.

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<strong>Introduction:&nbsp;</strong>Severe acute pancreatitis (SAP) requires accurate severity prediction. Studies show mixed results on BISAP and Ranson&rsquo;s scores. While some favor BISAP&rsquo;s early prediction, others find comparable accuracy. The debate continues, balancing BISAP&rsquo;s simplicity with Ranson&rsquo;s comprehensiveness. Future research aims to refine scoring systems and incorporate advanced diagnostic tools.&nbsp;<strong>Methods:&nbsp;</strong>Demographic, clinical, and biochemical data were collected at baseline and 48 hours post-admission. Ranson&rsquo;s and BISAP scores were assigned to each patient and compared with the revised Atlanta classification for acute pancreatitis (AP). Parameters evaluated included age, gender, etiology, and various biochemical markers, among others, with data tabulated and graphically presented.&nbsp;<strong>Results:&nbsp;</strong>Among 101 patients, BISAP scores distribution was: 5.94% scored 0, 24.75% scored 1, 34.65% scored 2, 18.81% scored 3, 10.89% scored 4, and 4.95% scored 5; mean score was 2.18&plusmn;1.23. SAP was observed in 27.72% of patients, with 6.93% mortality. Ranson&rsquo;s score &ge;3 was in 36% of patients. BISAP score demonstrated higher predictive ability for SAP (OR=2.67, P=0.0003) than Ranson&rsquo;s (OR=1.47).&nbsp;<strong>Conclusion:&nbsp;</strong>Our study provides evidence supporting the superior predictive capability of the BISAP score compared to Ranson&rsquo;s criteria in identifying SAP cases. Early risk stratification using the BISAP score can aid clinicians in optimizing patient management and improving outcomes in AP.
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8

Sagi, Srikanth, and Keerthi Bharati. "Assessment of Severity of Pancreatitis by Computerized Tomography Using Revised Atlanta Classification and Comparison with BISAP Clinical Scoring System." Perspectives in Medical Research 10, no. 3 (2022): 9–13. http://dx.doi.org/10.47799/pimr.1003.03.

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Abstract Background: Untreated acute pancreatitis can have high morbidity and mortality. It is a serious gastrointestinal emergency. Its incidence is approximately 51.0 % and it can cause both local and systemic problems. The diagnosis usually involves laboratory tests like amylase and lipase as well as an ultrasound exam. The ideal imaging test is a contrast-enhanced CT scan. This study used scoring systems based on laboratory and radiological investigations to determine the clinical progression and outcome. Methods : Patients who were diagnosed with acute pancreatitis and in whom computed tomography was done were included. From the imaging findings, the category and subcategory of acute pancreatitis and types of fluid collections were described in these patients using the revised Atlanta classification. BISAP score was calculated in all these patients. The clinical outcome assessed in these patients is the duration of stay in the hospital, mortality, presence of persistent organ failure, the occurrence of infection and need for intervention. Finally, the correlation between the Revised Atlanta classification and BISAP score was analyzed and compared with clinical outcomes. Results: The analysis of the correlation between Revised Atlanta classification severity grade and BISAP score, among the n=57 patients with mild acute pancreatitis n=56, had BISAP score less than 3 and only one had BISAP score greater or equal to three. Among the n=25 patients graded as moderately severe acute pancreatitis, n=20 cases had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three. Among the n=08 patients graded as severe acute pancreatitis, n=3 had a BISAP score of less than 3 and n=5 had BISAP score greater than or equal to three. Conclusion: Standardizing nomenclature and facilitating proper documentation of a variety of imaging abnormalities in acute pancreatitis is made possible by incorporating the new Atlanta categorization system into daily practice. We can triage, predict, and treat patients with acute pancreatitis with greater precision by integrating the new Atlanta classification with BISAP clinical grading, significantly improving medical care.
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Amit, Parashar, Ranjan Rajeev, Chakraborty Deboshubhra, and Kumar Sudhir. "A Prospective Study of the BISAP Score in Predicting Severity and Prognosis of Acute Pancreatitis in a Tertiary Care Hospital in Southern Bihar Region." International Journal of Pharmaceutical and Clinical Research 14, no. 8 (2022): 481–86. https://doi.org/10.5281/zenodo.13356860.

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<strong>Aim:</strong>&nbsp;A prospective study of the bedside index for severity in acute pancreatitis (BISAP) score in predicting severity and prognosis of acute pancreatitis.&nbsp;<strong>Methods:</strong>&nbsp;The present Prospective study was conducted in the Department of General Surgery, Narayan Medical College and Hospital, Sasaram, Bihar, India.The total number of patients included in the study was 50.&nbsp; Individual components of the BISAP scoring system were BUN &gt;25mg/dl, impaired mental status (Glasgow Coma Scale Score &lt;15) and SIRS (systemic inflammatory response syndrome).&nbsp;<strong>Results:</strong>&nbsp;Out of 50 patients 45 (90%) were males and 5 (10%) were females. Thus, a male preponderance was observed in this disease. Out of 50 patients, 40 had BISAP score ˂2. Among them, 37 patients (92.5%) had a hospital stay for &le;7 days and only 3 patients (7.5%) had a hospital stay for &gt;7 days. 10patients had BISAP score &ge;2. Among them, 9 patients (90%) had a hospital stay for &gt;7 days and only 1 patient (10%) had a hospital stay for &le;7 days. Hence, BISAP Score &ge;2 was associated with prolonged hospital stay. In this study, BISAP score had a sensitivity of 70%, specificity of 92.5%, positive predictive value of 70, negative predictive value of 92.5%, false positive rate of 7.5% and false negative rate of 30% in predicting severe acute pancreatitis and poor prognosis.&nbsp;<strong>Conclusion:&nbsp;</strong>It can be concluded that BISAP score is accurate in predicting severity and prognosis of acute pancreatitis. Patients diagnosed with acute pancreatitis having BISAP score &ge;2 are prone to develop severe pancreatitis and carried poor prognosis while patients with BISAP score &lt;2 develop only mild pancreatitis and have better prognosis. &nbsp; &nbsp; &nbsp;
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Balasubramaniam, V. "Comparative study between BISAP score and Ranson score in predicting severity of acute pancreatitis." International Surgery Journal 8, no. 3 (2021): 920. http://dx.doi.org/10.18203/2349-2902.isj20210518.

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Background: Acute pancreatitis has widely variable clinical and systemic manifestations spanning the spectrum from a mild, self-limiting episode of epigastric pain to severe, life-threatening, multi-organ failure. Since the morbidity and mortality of acute pancreatitis differ markedly between mild and severe disease (mild &lt;5% versus severe 20–25%), it is very important to assess severity as early as possible. To assess the accuracy of the BISAP scoring system versus Ranson scoring system in predicting severity in an attack of acute pancreatitis.Methods: It is a prospective and retro prospective study that was conducted, from August 2018 to November 2019. All surgical units in the headquarters hospital, Ooty. BISAP score and Ranson’s score is calculated in all such patients based on data obtained within 48 hours of hospitalization.Results: Ranson’s score of more than 3 and the BISAP score of less than or equal to 3 had the best accuracy of predicting the severity of acute pancreatitis. Both Ranson’s score and BISAP score showed higher sensitivity in the prediction of systemic complications than that of local complications.Conclusions: From this study, we can conclude that the BISAP scoring system is not inferior to Ranson’s scoring system in predicting the severity of acute pancreatitis. BISAP scoring system is very simple, cheap, easy to remember and calculate. BISAP scoring system accurately predicts the outcome in patients with acute pancreatitis.
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Güzel, Yunus Emre, Nese Çolak, Ahmet Can Okuv, Sefer Teymuroğlu, and Muhammet İkbal Teke. "Comparing prognostic scoring systems in acute pancreatitis: Bedside Index of Severity in Acute Pancreatitis, WL, and Chinese Simple Scoring System Scores." Turkish Journal of Emergency Medicine 24, no. 3 (2024): 165–71. http://dx.doi.org/10.4103/tjem.tjem_14_24.

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Abstract OBJECTIVES: Several scoring systems are used to predict prognosis in acute pancreatitis (AP), but their predictive success varies. This study compares the validity of the commonly used Bedside Index of Severity in AP (BISAP) score with the newly developed WL score and the Chinese Simple Scoring System (CSSS) score in predicting mortality and unfavorable prognostic outcomes in AP patients. METHODS: This retrospective descriptive study included all AP patients presenting to the emergency department from June 2, 2019, to June 2, 2022. Patient demographics, vital signs, laboratory values, and imaging findings were recorded, and WL, CSSS, and BISAP scores were calculated. The effectiveness of these scores in predicting adverse outcomes and mortality was compared. RESULTS: Among 357 patients, 53.2% were male, with a median age of 62 years (interquartile range: 48–75). Area under the curve (AUC) values for 7-day outcomes were 0.956 for WL, 0.759 for CSSS, and 0.871 for BISAP; for 30-day outcomes, AUC values were 0.941 for WL, 0.823 for CSSS, and 0.901 for BISAP; and for poor prognostic outcomes, AUC values were 0.792 for WL, 0.769 for CSSS, and 0.731 for BISAP. CONCLUSION: In AP patients, WL, CSSS, and BISAP scores are effective predictors of unfavorable prognosis and mortality. WL score outperforms the CSSS and BISAP scores in predicting 7-day and 30-day mortality and poor prognosis. After WL, BISAP is the second-best system for predicting mortality. For predicting unfavorable prognoses, CSSS is the second-best system after WL. The simplicity of calculating the WL score based on four laboratory parameters makes it a preferable choice.
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Maitra, Sanjay, Angel Ivy Toppo, Suchitra Pal, Bhabani Chanda Maitra, and Mohanchandra Mandal. "Correlation between BISAP score and D-dimer level on their predictive ability to determine the severity of acute pancreatitis at 24-hours of hospital admission: an observational study." Asian Journal of Medical Sciences 14, no. 3 (2023): 153–59. http://dx.doi.org/10.3126/ajms.v14i3.51352.

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Background: Early prediction of severity of acute pancreatitis (AP) is important for management of AP patients with escalation of care and aggressive therapy which can reduce complications. Bedside index of severity in AP (BISAP) score is helpful in early diagnosis of severe AP. D-dimer, a biomarker of secondary fibrinolysis may be helpful in predicting the severity of pancreatitis. Aims and Objectives: The objective of this study was to evaluate the two scoring systems - the BISAP score and D-dimer in early prediction (within 24 h) on the severity of AP and to analyze how D-dimer correlates with BISAP score. Materials and Methods: Seventy-five patients, aged 18–70 years, suffering from AP due to any cause were included for this prospective, observational study. Within 24 h of admission D-dimer was estimated and BISAP score was calculated. The severity was assessed based on D-dimer level and BISAP scoring systems within 24 h of hospital admission and data were tabulated for analysis. The D-dimer level &gt;2.5 mg/L was considered to be suggestive of severe pancreatitis. The BISAP score &gt;2 in first 24 h was defined as predictive of severe pancreatitis. Spearman rank correlation was used for an analysis of the association between two set of data (BISAP scores and d-dimer levels) and thus to measure the strength and direction of the relationship between the two variables. Results: In the present study, 37.3% of the patients had D-dimer ≤2.5 mg/L and 62.7% had D-dimer&gt;2.5 mg/L’ on calculating the Pearson’s correlation on the ranked values of the data (BISAP scores and D-dimer levels), the correlation coefficient (Spearman’s Rho, designated as “rs”) was found to be 0.406 which indicates about moderate positive correlation. Conclusion: D-dimer testing can be used as an alternative test to predict the severity of AP. It shows a moderate correlation with BISAP scoring.
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C. M., Gokul, and Anand Ignatius Peter. "A comparative study between BISAP and Ranson’s score in predicting severity of acute pancreatitis." Biomedicine 43, no. 6 (2024): 1892–95. http://dx.doi.org/10.51248/.v43i6.2910.

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Introduction and Aim: Acute pancreatitis has variable clinical and systemic indications checking the range from a mild illness to serious, hazardous, multiorgan dysfunction. Among different scoring systems used to assess seriousness in acute pancreatitis, BISAP (Bed side index for severity of acute pancreatitis) and Ranson scoring frameworks have been viewed as predictive and impressively utilized. This study targets surveying the predictive role of BISAP scoring in contrast with Ranson’s score for severity of acute pancreatitis. Materials and Methods: All patients with acute pancreatitis will be assessed and their full medical history, complete clinical examination, biochemical studies, will be gathered. Prediction of severity by BISAP and Ranson as compared to severity using Revised Atlanta classification was done using kappa coefficient, specificity, positive predictive value, negative predictive value and accuracy. Results: In this study out of 150 patients in the study population, most were in the age group between 25 to 45, with male predominance. 137 (89.3%) mild and 16 (10.7%) severe coarse are found in our study. Sensitivity (100 %), specificity (57.4 % vs 56.7), positive predictive value (21.9 vs 21.62%) and negative predictive value (100%) were found when BISAP was compared to Ranson’s in our study. Conclusion: In this study, we can come to a conclusion that BISAP is similarly effective in predicting the severity of acute pancreatitis as Ranson's scoring system. BISAP is simple to use, modest, easy to calculate and it does not need 48 hours for completion when compared to Ranson’s. Consequently, BISAP can be performed on bedside of patients with acute pancreatitis in any setup.
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Anil, Chouhan, Shakti Yadav Shiv, Sukhla Varsha, and Kumar Giri Rahul. "Assessment of Accuracy of BISAP Score as a Predictor of Severe Acute Pancreatitis in Shyam Shah Medical College, Rewa, Madhya Pradesh." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 1762–68. https://doi.org/10.5281/zenodo.12604717.

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<strong>Background:</strong>&nbsp;The prevalence of acute pancreatitis&nbsp; (AP)&nbsp; has increased in the last&nbsp; 20&nbsp; years. Most patients with AP experience a clinical course that is mild and self-limited. However, 10% to 20% of patients develop a rapidly progressive inflammatory response, necessitating prolonged hospital stays, and high morbidity and mortality rates. Various scoring systems are already in place to assess the severity of acute pancreatitis. BISAP score offers the advantages of being inexpensive, rapid, and simple.&nbsp;<strong>Aim and Objectives:&nbsp;</strong>To analyze the predictive value of BISAP score in developing severe AP (SAP) and mortality rates.&nbsp;<strong>Materials and Methods:</strong>&nbsp;This study enrolled 138 patients with acute pancreatitis admitted to surgical wards of Shyam Shah Medical College Rewa, Madhya Pradesh, between January 2022 to December 2022, meeting the inclusion criteria.&nbsp;<strong>Results:</strong>&nbsp;The percentage of severity,&nbsp; necrosis,&nbsp; various organ failure,&nbsp; death,&nbsp; and hospital stay increased as the BISAP score increased. Regarding sensitivity and specificity, the accuracy of the BISAP score for predicting severe acute pancreatitis was 76.2% and 63.4%. Patients with severe acute pancreatitis had BISAP scores of 3 and above.&nbsp;<strong>Conclusions:</strong>&nbsp;BISAP can be used to identify the patients who are at risk, and this information can serve as early guidance for appropriate and necessary therapy,&nbsp; improving patient outcomes. The present study concludes the increased accuracy of the BISAP score for risk stratification. &nbsp; &nbsp; &nbsp;
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Singh Walia, Bhupinder, Pankaj Dugg, Gagandeep Singh, Sanjeev Sharma, and Manjeet Singh Sandhu. "Evaluation of acute pancreatitis based on BISAP scoring system: A cohort study of 50 cases." Acta Medica Martiniana 22, no. 3 (2022): 144–54. http://dx.doi.org/10.2478/acm-2022-0016.

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Abstract Background/Aim Acute pancreatitis is encountered in both medical and surgical specialty. Assessment of severity and grading is done using radiological investigations mostly like ultrasonography or CECT. We present a study to assess the severity of Acute Pancreatitis based on Bedside Index for Severity in Acute Pancreatitis (BISAP) scoring system. Material &amp; Methods The study was conducted on 50 patients presenting with acute pancreatitis who were included as per inclusion criteria and a detailed history, clinical examination and blood investigation performed. Data like serum amylase, serum lipase, serum calcium, blood urea nitrogen (BUN), pleural effusion and systemic inflammatory response syndrome (SIRS) was collected from the patients. Based on data collected in 24 hours of hospitalization, BISAP score was calculated. Results Results showed that no significant temperature rise, pancreatic necrosis, SIRS or impaired mental status in patients with BISAP severity of &lt;=3. However, patients having BISAP score &gt;3, factors like BUN, age, pleural effusion, and organ failure show significant correlation. Also on comparative analysis of patients showed that the hospital stay, respiratory rate, pulse and laboratory markers (blood urea, serum creatinine, serum amylase, serum lipase) were significantly higher in patients with BISAP score ≥3. Conclusion BISAP score is an easy, quick and bedside method to assess the severity of acute pancreatitis and predict its mortality. It is easy bedside procedure that can be done in every setup.
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M. R., Kaushik, A. P. Dubey, Rahul Jain, Anvesh Rathore, and Abhishek Pathak. "Prospective evaluation of the BISAP score and its correlation with Marshall score in predicting severity of organ failure in acute pancreatitis." International Journal of Advances in Medicine 4, no. 2 (2017): 534. http://dx.doi.org/10.18203/2349-3933.ijam20171056.

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Background: The bedside index for severity in acute pancreatitis (BISAP), a newer prognostic scoring system, has been proposed as a simple and clinically oriented severity scoring system for early identification of patients with acute pancreatitis. This study evaluates the efficacy of BISAP score to predict the severity of organ failure in patients of acute pancretitis and its correlation with Marshall score.Methods: The clinical, laboratory and radiological data for all patients admitted with a diagnosis of acute pancreatitis conducted at tertiary hospital of Armed Forces over a two-year period, was prospectively collected for this study. BISAP score was calculated within 24hrs of presentation. Markers of severity were the development of organ failure and presence of pancreatic necrosis. Outcome at 28 days (viz. recovery, organ failure and mortality) was studied for each patient. BISAP score computed at 24h was correlated with the above and its efficacy to predict the severity of organ failure in Acute Pancreatitis, was assessed.Results: Out of 50 patients in the study group, 41 were male and 9 were female with the mean (±SD) age 43.74±16.85 years. Majority of the study population had alcohol (56%) as the etiology followed by gall stones (28%). Outcome assessed at 28 days revealed recovery of 54%, complication of 36% and mortality of 10% of study population. BISAP score computed within 24 hours of admission of 2 or more significantly predicted the severity and complication with P value &lt;0.001. Statistically significant trends of increasing severity and organ failure (P&lt;0.001) with increasing BISAP was observed.Conclusions: BISAP score is a reliable means of predicting the severity and organ failure and stratifying patients with Acute Pancreatitis within 24 hours of admission. The statistically significant incidence of increasing severity and mortality with increasing BISAP score will help us to risk stratify the patients within 24 hours of admission and help improve clinical care and facilitate necessary interventions as early as possible.
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Ghunage, Aditya Vasant, and Kiran Shrikant Kher. "Assessment of BISAP Scoring System and C-Reactive Protein Analysis in Predicting Severity of Acute Pancreatitis." Journal of Evolution of Medical and Dental Sciences 10, no. 35 (2021): 2985–88. http://dx.doi.org/10.14260/jemds/2021/610.

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BACKGROUND Acute pancreatitis (AP) is a dormant deadly illness. The range of seriousness of the ailment goes from mellow self-restricting disease to an exceptionally lethal severe necrotizing pancreatitis. The disease has such a variable course that it may manifest as a simple pain in the abdomen to severe haemorrhagic pancreatitis with septicaemic shock, multi-organ dysfunction syndrome and ultimately leading to death. A cost-effective better prognosticative index is needed for the assessment of the severity of AP. Here in this study, we wanted to assess the role of BISAP scoring systems and CRP for analysis and comparing their values to determine the severity of AP and the prognosis of the disease. METHODS A prospective observational study was done on 83 patients diagnosed with AP after fulfilment of inclusion criteria. Patients were subjected to severity index, bedside index for severity in acute pancreatitis (BISAP) score and CRP calculation and statistical analysis was done with SPSS software. RESULTS In our study, AP was more prevalent in males 87.95 % than females 12.05 %. AP was found to be more common in cases ≤ 40 years of age, however, the mean age of presentation was 38.14 ± 12.59 years. We calculated the sensitivity and specificity of the BISAP score and C-reactive protein (CRP) by co-relating it with CT severity index as gold standard according to which the sensitivity was found to be 64 % and specificity was found to be 85 % for BISAP. The sensitivity and specificity of CRP was 64 % and 85 % respectively. CONCLUSIONS BISAP is an easy way to anticipate the severity of AP within 24 hours. It also helps to prognosticate AP. CRP can also be used to aid BISAP in the assessment of severe acute pancreatitis (SAP). KEY WORDS Acute Pancreatitis, BISAP, CRP.
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Wang, Yu, Guangbo Qu, Zhangbi Wu, et al. "Early predictive value of scoring systems and routine laboratory tests in severity and prognosis of acute pancreatitis in pregnancy." Therapeutic Advances in Gastroenterology 16 (January 2023): 175628482311672. http://dx.doi.org/10.1177/17562848231167277.

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Background: Currently, no guidelines specifically recommend scoring systems and biomarkers for early evaluation of the severity and prognosis of acute pancreatitis in pregnancy (APIP). Objectives: This study aimed to explore the early predictive value of scoring systems and routine laboratory tests on APIP severity and maternofetal prognosis. Design: This study retrospectively analyzed 62 APIP cases in a 6-year period. Methods: The predictive value of scoring systems and routine laboratory tests that were collected 24 h and 48 h after admission, for APIP severity and fetal loss, were analyzed. Results: To detect severe acute pancreatitis (SAP), a 24-h Bedside Index for severity in acute pancreatitis (BISAP) achieved a higher area under the curve (AUC) value of 0.910 than the Acute Physiology and Chronic Health Evaluation II (AUC = 0.898) and Ranson score (AUC = 0.880). The combination of BISAP, glucose, neutrophil-to-lymphocyte ratio (NLR), hematocrit (Hct), and serum creatinine (Scr) provided an AUC value of 0.984, which had greater predictive power than BISAP ( p = 0.015). 24-h BISAP and Hct were independent risk factors for predicting SAP of APIP. The cutoff values of Hct and blood urea nitrogen (BUN) to predict SAP were 35.60% and 3.75 mmol/l in the APIP. Furthermore, 24-h BISAP had the highest predictive power (AUC = 0.958) for fetal loss. Conclusion: BISAP is a convenient and reliable indicator for the early prediction of SAP and fetal loss in APIP. The combination of BISAP, glucose, NLR, Hct and Scr proved to be the optimal early markers for the prediction of SAP in APIP within 24 h after admission. In addition, Hct &gt; 35.60% and BUN &gt; 3.75 mmol/l may be suitable thresholds for predicting SAP in APIP.
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Karki, Sanjit, Binod Karki, Suresh Thapa, Roshan Shrestha, Bidhan Nidhi Poudel, and Ramila Shrestha. "Accuracy of bedside index for severity in acute pancreatitis ‘BISAP’ score in predicting outcome of acute pancreatitis." Journal of Patan Academy of Health Sciences 7, no. 2 (2020): 70–76. http://dx.doi.org/10.3126/jpahs.v7i2.31117.

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Introduction: Early identification of severe acute pancreatitis is of paramount importance in the management and for improving outcomes. Bedside index for severity in acute pancreatitis (BISAP) is a simple and accurate score for stratification in acute pancreatitis. This study was conducted to find out the accuracy of BISAP score in predicting outcomes of acute pancreatitis in local population.&#x0D; Method: We prospectively analyzed 96 patients with acute pancreatitis from February 2019 to December 2019. Revised Atlanta classification was used to stratify mild, moderately severe and severe pancreatitis. BISAP score was calculated within 24 hours of admission. Accuracy was measured by area under receiver operating curve (AUC).&#x0D; Result: Out of 96 patients, alcohol related acute pancreatitis accounted for 74.7%. There were 63.2% of mild AP, 37.3% of moderately severe AP, 9.4% of severe AP and 15.8 % of pancreatic necrosis. The AUC for moderately severe AP, severe AP and pancreatic necrosis were 0.77 (CI 0.68-0.87), 0.95 (CI 0.90-0.99) and 0.87 (CI 0.79-0.96) respectively. The statistically significant BISAP cut off for diagnosing sever AP was≥3, and ≥2 for moderately sever AP and pancreatic necrosis. There was positive correlation between revised Atlanta severity of acute pancreatitis and length of hospital stay (r=0.41). Mortality was 3.3 % which was seen in BISAP score 3 or above.&#x0D; Conclusion: BISAP is a simple predictive model in identifying patient at a risk of developing different severity of pancreatitis and its outcome in our population.
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Durganna Thimmappa and Gokul R. . "BISAP plus serum lactate dehydrogenase: a new scoring system for assessment of severity of acute pancreatitis." International Surgery Journal 10, no. 5 (2023): 882–87. http://dx.doi.org/10.18203/2349-2902.isj20231385.

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Background: Acute Pancreatitis is a process of acute inflammation of pancreas along with peripancreatic tissue and multi organ involvement. To reduce morbidity and mortality by predicting the course of the disease and do an early intervention several scoring systems have been proposed such as RANSON’S score, BISAP score, APACHE II etc. Methods: Patients are chosen with clinical diagnosis of acute pancreatitis over a period of 6 months, based on inclusion criteria, with consent. They underwent investigations base d on the scoring systems and institutional protocol. The different scoring systems were used and calculated. The effectiveness of all the scoring systems were calculated using Microsoft Excel indicating its sensitivity, specificity, accuracy, positive and negative predictive value. Results: BISAP with LDH (BISAP PLUS) shows the highest sensitivity (85.71%), Positive predictive value (70.59%), Negative predictive value (84.62%) and Accuracy (76.67%) among different scoring systems. The highest specificity was seen in APACHE II (75%) Conclusions: Use of BISAP plus serum LDH (BISAP plus) can help in daily assessment and quicker management of acute pancreatitis and should be studied further, as it is showing promise in helping in management of acute pancreatitis.
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Karpavičius, Andrius, Žilvinas Dambrauskas, Artūras Samuilis, et al. "KLINIKINIŲ IR RADIOLOGINIŲ SKALIŲ VERTĖ PROGNOZUOJANT ŪMINIO PANKREATITO EIGĄ IR KOMPLIKACIJAS. PERSPEKTYVINIO DAUGIACENTRIO KOHORTINIO TYRIMO REZULTATAI." Medicinos teorija ir praktika 21, no. 4.3 (2015): 814–21. http://dx.doi.org/10.15591/mtp.2015.129.

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Reikšminiai žodžiai: pankreatitas, prognozavimas, BISAP, CTSI, MCTSI. Darbo tikslas. Įvertinti klinikinių bei radiologinių skalių vertę, prognozuojant ŪP eigą, kasos nekrozę, intervencijų poreikį ir išeitis. Medžiaga ir metodai. Multicentrinė perspektyvinė studija buvo vykdoma keturiose Vilniaus ir Kauno gydymo įstaigose. Hospitalizuotų dėl ūminio pankreatito pacientų būklė 1-ąją hospitalizacijos parą įvertinta naudojant HAPS ir BISAP prognozines skales, apskaičiuojant surinktus balus. 3–7-ą susirgimo parą pacientams buvo atliekama pilvo organų kompiuterinė tomografija su intaveniniu kontrastavimu ir apskaičiuoti CTSI ir MCTSI skalių balai. Remiantis atnaujintu Atlantos sutarimu, visi pacientai buvo suskirstyti į tris grupes pagal ligos eigą: lengvo, vidutinio sunkumo ir sunkaus ūminio pankreatito. Klinikinių ir radiologinių skalių balai buvo lyginami tarp grupių, ir, braižant ROC kreives, nustatytos kritinės reikšmės, kuriomis remiantis galima prognozuoti sunkios eigos ūminį pankreatitą, kasos nekrozę, intervencijas bei išeitis. Rezultatai. Tyrime dalyvavo 102 ūminiu pankreatitu sirgę pacientai. Iš jų lengvu ūminiu pankreatitu sirgo 27 (26,5%), vidutinio sunkumo – 55 (53,9%) ir sunkiu – 20 (19,6%) asmenų. Nustatyta, jog BISAP (kritinė reikšmė ≥2), CTSI (kritinė reikšmė ≥6) bei MCTSI (kritinė reikšmė ≥8) skalės statistiškai patikimai atskiria sunkiu ūminiu pankreatitu sergančius pacientus nuo sergančių lengvesnėmis formomis. Kasos nekrozės kritinės prognozinės reikšmės yra ≥2 (BISAP), ≥3 (CTSI) ir ≥5 (MCTSI) balai. BISAP skalės kritinė prognozinė vertė intervencijoms yra ≥3 balai, CTSI – ≥5, o MCTSI – ≥8 balai; paciento mirtį atitinkamai prognozuoja – ≥4, ≥6 ir ≥8 balai. Išvados. BISAP prognozinė sistema yra gana tiksli, universali ir ankstyva prognozuojant SŪP, kasos nekrozę, intervencijas bei išeitis. Radiologinės skalės tinkamos ŪP eigai prognozuoti, tačiau yra per daug vėlyvos ir labiau naudingos gydymo taktikai parinkti.
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Ullah, Rahman, Mashal Nazir, Farooq Khan, et al. "Comparative Evaluation of Bedside Index of Severity in Acute Pancreatitis Bisap) & Modified Computed Tomography Severity Index (MCTSI) in Assessing Severity of Acute Pancreatitis." Pakistan Journal of Medical and Health Sciences 16, no. 5 (2022): 1444–46. http://dx.doi.org/10.53350/pjmhs221651444.

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Objective: To compare diagnostic accuracy of BISAP and MCTSI in predicting the severity of Acute pancreatitis. Study design: cross sectional study. Setting: Surgical department Khyber Teaching Hospital, Peshawar and Bacha Khan Medical Complex, Swabi. Duration: 6 months Jan, 2021 to June, 2021 Material and Methods: In this study a total of 246 patients were observed. The demographic, clinical and laboratory data of all consecutive patients with a primary diagnosis of AP admitted/transferred to our ward were prospectively collected and then this data were retrospectively analyzed. The day of admission is defined as the first 24hr of hospitalization in our ward or in the referring hospital/ward. Contrast enhanced CT(CECT) and BISAP score were calculated after 72hrs in all patients and they were categorized into three severity grades of Acute pancreatitis based on Atlanta classification 2012 as discussed in operational definition. BISAP score greater than 4 and MCTSI score greater than 8 were considered severe acute pancreatitis. Results: In this study mean age was 45 years with SD ± 16.21. Forty three percent patients were male while 57% patients were female. MCTSI had sensitivity 89.83%, specificity 60%, Positive predictive value was 98.14%, Negative predictive value was 20% and the overall diagnostic accuracy was 88.61%. While BISAP had sensitivity 82.05%, specificity 70%, Positive predictive value was 98.49%, Negative predictive value was 14.89% and the overall diagnostic accuracy was 82.52%. Conclusion: Our study concludes that the diagnostic accuracy of MCTSI is better than BISAP score in predicting the severity of acute pancreatitis. Keywords: MCTSI, BISAP score, severe acute pancreatitis.
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Jingoniya, Narottam K., Bhanwar L. Yadav, Pradeep K. Verma, Somendra Bansal, and Shalu Gupta. "Comparative evaluation of BISAP score and computed tomography severity index as a predictor for severity of acute pancreatitis." International Surgery Journal 9, no. 2 (2022): 421. http://dx.doi.org/10.18203/2349-2902.isj20220335.

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Background: Acute severe pancreatitis is life threatening condition with organ failure, pancreatic necrosis, infections, and death. Multiple factor scoring systems are used for triage decision to manage of acute pancreatitis according to severity. Our purpose of this study was to assess the efficiency of the bedside index of severity in acute pancreatitis (BISAP) score and computed tomography severity index (CTSI) scoring system to predict severity of acute pancreatitis.Methods: This hospital based observational, prospective study was conducted from 01 March 2019 to May 2020. An inclusion criterion was patients admitted with diagnosis of acute pancreatitis. Comparative analysis was done for BISAP and CTSI in terms of severity and mortality.Results: The mean age was 44.7±16.2 years and male to female ratio was 1.9:1. BISAP score had 91.7% sensitivity and 51.4% specificity in predicting severity of acute pancreatitis with 38.6% positive predictive value (PPV) and 94.9% negative predictive value (NPV). CTSI score had 95.8% sensitivity and 44.4% specificity in predicting severity of acute pancreatitis with 36.5% PPV and 96.9% NPV. The area under curve (AUC) for BISAP and CTSI was 0.853 (95% CI: 0.769–0.937) and 0.901 (95% CI: 0.831– 0.97) respectively.Conclusions: We conclude that BISAP score is better predictor of severity and mortality in acute pancreatitis and can safely be utilized to predict severity of acute pancreatitis in situations where use of CT is limited due to cost factor or availability, especially in rural areas. BISAP score is a scoring system that can be easily calculated with available clinical data even in small hospital setups.
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Marinkovic, Olivera, Sladjana Trpkovic, Ana Sekulic, et al. "The importance of using inflammatory biomarkers and scoring systems in early assessment of severity and outcome of acute pancreatitis treatment." Acta Poloniae Pharmaceutica - Drug Research 79, no. 5 (2023): 735–42. http://dx.doi.org/10.32383/appdr/158169.

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Acute pancreatitis (AP) is an inflammatory disease of the pancreas that causes local damage and systemic inflammatory response. Some of the numerical scoring systems used in the intensive care unit for the assessment of critically ill patients such as APACHE II and MEWS score could be used for AP, beside the scoring systems specific to AP (Ranson score, Pancreas score, BISAP). Therefore, the aim of this study was to examine the significance of inflammatory biomarkers and scoring systems in the evaluation of the severity of AP and outcomes. The study was conducted as a cohort prospective study, examining patients with AP, of both sexes. Laboratory analyses, as well as the scoring systems: Ranson, Pancreas score, Bedside Index of Severity in Acute Pancreatitis (BISAP), and Acute Physiology and Chronic Health Evaluation II (APACHE II) were collected on day zero and 48h after admission. The study included 50 patients of whom 8 died. The most reliable score for predicting AP severity was APACHE II0 and 48AUROC (0.753; 0.768) in relation to the inflammatory biomarkers. For initial prediction of the treatment outcome, APACHE II0, BISAP0, and CRP0 AUROC (0.813; 0.807; 0.753) had the highest discrimination rates and after 48h, APACHE II48, Ranson48, BISAP48, and Pancreas48 AUROC (0.917; 0.856; 0.789; 0.729). There was a statistically significant correlation between CRP0 and BISAP0 (p=0.006) and between PCT and all day-zero scores. All tested screening systems showed reliability in predicting AP severity and treatment outcomes. The best predictive power was demonstrated by the APACHE II score.
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Theerthegowda, Akhila Nallur, Pavithra Umashankar, and Nagashri Suresh Iyer. "A Comparative Study between Bedside Index for Severity in Acute Pancreatitis (BISAP) and Acute Physiology and Chronic Health Evaluation (APACHE-II) Scoring System in Assessing the Severity of Acute Pancreatitis at Bangalore Medical College and Research Institute, Bangalore, India." Journal of Evidence Based Medicine and Healthcare 8, no. 36 (2021): 3269–75. http://dx.doi.org/10.18410/jebmh/2021/594.

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BACKGROUND Acute pancreatitis (AP) is an inflammatory disease of the pancreas, that results from intrapancreatic activation, release, and digestion of the organ by its own enzymes. The diagnosis of acute pancreatitis can be made when a patient presents with threefold elevated serum levels of amylase or lipase, abdominal pain and vomiting. In this study, we wanted to assess the severity of acute pancreatitis by using BISAP (Bedside index for severity in acute pancreatitis) and APACHE-II (Acute physiology and chronic health evaluation) scoring systems and compare the accuracy of BISAP scores with APACHE-II scores. METHODS A prospective study including 201 patients was conducted from April 2018 to March 2020 in Victoria Hospital, affiliated to BMCRI. RESULTS Among 201 AP patients, 129 were found to have mild acute pancreatitis (MAP), 72 were of severe acute pancreatitis (SAP), 192 survival cases, and 9 death cases. The larger the rating score, the higher the proportion of severe pancreatitis and mortality risk. Two kinds of scoring criteria; BISAP score points and Apache II score points compared in patients with MAP and SAP, In Apache II score to predict severity of organ failure, the sensitivity, specificity, positive predictive value, negative predictive value was 84.72 %, 93.02 %, 87.14 %, 91.60 % and area under the curve was 0.958 (P &lt; 0.0001). In BISAP, the sensitivity, specificity, positive predictive value, negative predictive value was 90.28 %, 80.62 %, 72.22 %, 93.69 % and area under the curve was 0.917 (P &lt; 0.0001). CONCLUSIONS Ability of APACHE II score prediction of AP in severity of organ failure and mortality are stronger than BISAP score, But APACHE II scoring system indicators were cumbersome, complicated assessment. BISAP scoring system is simple, economical, rapid and reliable, and it can effectively predict the severity and mortality of acute pancreatitis, and can be used as a preliminary screening method in accurate risk stratification and initiation of management accordingly at community health care, secondary health care and tertiary health care Hospitals. KEYWORDS Pancreatitis, Severity, Prediction, APACHE II and BISAP
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Chen, Lifen, Guomin Lu, Qunyan Zhou, and Qiang Zhan. "Evaluation of the BISAP Score in Predicting Severity and Prognoses of Acute Pancreatitis in Chinese Patients." International Surgery 98, no. 1 (2013): 6–12. http://dx.doi.org/10.9738/0020-8868-98.1.6.

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Abstract The present study was to evaluate the accuracy of bedside index for severity in acute pancreatitis (BISAP) in predicting the severity and prognoses of acute pancreatitis (AP) in Chinese patients. Clinical data for 497 patients with AP were analyzed retrospectively to compare BISAP with acute physiology and chronic health evaluation II, Ranson, and computed tomography severity index scores in predicting the severity of AP and the occurrence of pancreatic necrosis, mortality, and organ failure in patients with severe AP (SAP) using the area under the receiver-operating characteristic curve. Of the 497 patients, 396 had mild AP and 101 had SAP. There were significant correlations between the scores of any two systems. BISAP performed similarly to other scoring systems in predicting SAP, as well as pancreatic necrosis, mortality, and organ failure in SAP patients, in terms of the area under the receiver-operating characteristic curve. BISAP score is valuable in predicting the severity of AP and prognoses of SAP in Chinese patients.
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Kuntoji, Shrikant B., and Shaik Karimulla. "Efficacy of BISAP score versus Ranson’s score to determine the severity index of acute pancreatitis." International Surgery Journal 8, no. 6 (2021): 1826. http://dx.doi.org/10.18203/2349-2902.isj20212279.

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Background: Acute pancreatitis has widely variable clinical and systemic manifestations spanning the spectrum from a mild, self-limiting episode of epigastric pain to severe, life-threatening, multiorgan failure posing a significant therapeutic challenge for the health care providers. Bedside index of severity in acute pancreatitis (BISAP) is a scoring system that would precisely predict severity as early as within the first 24 hours of the course of acute pancreatitis. This study aims to compare BISAP and Ranson’s score to establish the validity of a simple and accurate clinical scoring system for stratifying patients.Methods: All 84 cases admitted at HSK Hospital and SNMC, Bagalkot and diagnosed as acute pancreatitis were included in this study, from January 2019 to June 2020. Clinical evaluation in the form of detailed history, per abdominal, systemic examination and laboratory investigations, both BISAP and Ranson’s score were applied and compared, based upon data obtained at admission, within 24 hours and at 48 hours of hospitalization.Results: Out of 84 cases with a male to female ratio of 16:1, majority belonged to age group 31-40 years (42%) and most common etiological factor being alcohol consumption (74%); 19% patients had severe acute pancreatitis and 68% patients had length of hospital stay less than a week. Major organ failure and pancreatic necrosis, severity of BISAP and Ranson’s score were found to be significantly correlated, (p&lt;0.001); mortality was found to be 1.2%.Conclusions: Compared to Ranson’s score, BISAP score is equally effective in finding out the frequency of severity and predicting mortality in patients with acute pancreatitis .The values in BISAP score are instantaneous with no time delay.
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Bezmarevic, Mihailo, Zoran Kostic, Miodrag Jovanovic, et al. "Procalcitonin and BISAP score versus c-reactive protein and APACHE II score in early assessment of severity and outcome of acute pancreatitis." Vojnosanitetski pregled 69, no. 5 (2012): 425–31. http://dx.doi.org/10.2298/vsp1205425b.

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Background/Aim. Early assessment of severity and continuous monitoring of patients are the key factors for adequate treatment of acute pancreatitis (AP). The aim of this study was to determine the value of procalcitonin (PCT) and Bedside Index for Severity in Acute Pancreatitis (BISAP) scoring system as prognostic markers in early stages of AP with comparison to other established indicators such as Creactive protein (CRP) and Acute Physiology and Chronic Health Evaluation (APACHE) II score. Methods. This prospective study included 51 patients (29 with severe AP). In the first 24 h of admission in all patients the APACHE II score and BISAP score, CRP and PCT serum concentrations were determined. The values of PCT serum concentrations and BISAP score were compared with values of CRP serum concentrations and APACHE II score, in relation to the severity and outcome of the disease. Results. Values of PCT, CRP, BISAP score and APACHE II score, measured at 24 h of admission, were significantly elevated in patients with severe form of the disease. In predicting severity of AP at 24 h of admission, sensitivity and specificity of the BISAP score were 74% and 59%, respectively, APACHE II score 89% and 69%, respectively, CRP 75% and 86%, respectively, and PCT 86% and 63%, respectively. It was found that PCT is highly significant predictor of the disease outcome (p &lt; 0,001). Conclusion. In early assessment of AP severity, PCT has better predictive value than CRP, and similar to the APACHE II score. APACHE II score is a stronger predictor of the disease severity than BISAP score. PCT is a good predictor of AP outcome.
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Razzaq, Azeen, Muhammad Haroon Abdullah, Zulquernain Ahmed Zoak, Paras Yousuf, Aan-E.-Arshad Sh, and Hajra Tariq. "The Effectiveness of BISAP Score for the Diagnosis of Severe Acute Pancreatitis." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 611–12. http://dx.doi.org/10.53350/pjmhs2023173611.

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Background: The clinical profile of severity of acute pancreatitis ranges from modest pancreatic inflammation to an unusually fatal acute necrotizing pancreatitis rightly known as severe acute pancreatitis (SAP). For the evaluation of clinical spectrum of pancreatitis, a more accurate models that is also cost-effective is required. Here, we sought to evaluate the contribution BISAP scoring systems to the diagnosis of severe of acute pancreatitis by comparing it with CT severity index. Settings and duration: This observational study was carried out at medicine department, Jinnah hospital, Lahore from 16th July 2022 to 15th January 2023. Sampling: Patients diagnosed with acute pancreatitis were registered. Acute pancreatitis was labelled based triad of classic epigastric pain, blood markers and imaging tool. BISAP score ≥3 was meant SAP and CT severity index for SAP included findings like necrosis and collection. Diagnostic accuracy was determined. Results: The patient's age ranged from 20 to 60 years with mean age of 36.41 + 9.362 years. The ratio of male to female participants was 2.3 to 1. For the diagnosis of SAP, the BISAP score's sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were each 95.8%, 55.2%, 85.2%, 83.3%, and 84.8%, respectively. Conclusion: Simple clinical tools like BISAP score could be helpful in diagnosing severe acute pancreatitis, precluding the need for expensive and technically complex imaging modalities. Keywords: Severe acute pancreatitis (SAP), BISAP Score, Diagnostic accuracy
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Papu, Bori, Kumar Pegu Ajit, Saha Roy Somnath, Ozah Jinku, Farzad Islam Navil, and Rahman Sofiur. "Accuracy and Predictability of PANC 3 Scoring System in Acute Pancreatitis." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1096–102. https://doi.org/10.5281/zenodo.11077808.

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<strong>Objective:</strong>&nbsp;To assess the severity of acute pancreatitis including mortality in relation to PANC 3 score and to evaluate the predictability of severity and mortality of PANC 3 score with BISAP scoring system.&nbsp;<strong>Methods:</strong>&nbsp;90 cases of acute pancreatitis aged more than &amp; equal to 12 years were enrolled in the study and patients with additional comorbidities such as cardiac failure, liver failure, renal failure, chronic obstructive pulmonary disease, diagnosed cases of chronic pancreatitis, and recurrent pancreatitis with a history of complications like pseudocysts and abscesses in the pancreas were excluded from the study. BISAP score and PANC 3 score were determined for the cases and compared.&nbsp;<strong>Results:</strong>&nbsp;To predict severe acute pancreatitis, receiver operating characteristic curve (ROC) produced AUC value of 0.918 for BISAP and 0.904 for PANC 3 score. To predict mortality, ROC curve produced AUC values of 0.885 for BISAP and 0.886 for PANC 3 score.&nbsp;<strong>Conclusion:</strong>&nbsp;PANC 3 score in predicting severe acute pancreatitis and mortality is comparable with that of BISAP score, as it is easy to calculate, simple to use, and does not require a person with experience, and simply needs data that are frequently acquired during or within 24 hours of presentation. &nbsp; &nbsp;
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Islam, Mohammad Sirajul, Ahmed Hossain, Daharul Islam, and Mahmuda Abira. "Efficacy of Bedside Index for Severity In Acute Pancreatitis (Bisap) Score As Predictor of In-Hospital Outcome in Acute Pancreatitis." Bangladesh Journal of Medicine 35, no. 2 (2024): 88–92. http://dx.doi.org/10.3329/bjm.v35i2.72610.

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Background: Acute pancreatitis is a potentially life-threatening condition characterized by inflammation of the pancreas. Early identification of patients at risk of severe disease is crucial for devising appropriate management strategies and improving outcomes. The aim of the study was to investigate the efficacy of BISAP score as predictor of in-hospital outcome in patients with acute pancreatitis. Methods: This was a longitudinal study conducted in Department of Medicine, Sir Salimullah Medical College Mitford Hospital, Dhaka from January 2023 to December 2023. After ethical approval, a total 107 subjects were included in this study based on inclusion and exclusion criteria. Severity of the disease was assessed by BISAP score. Theoutcome determinants were length of hospital stay, complete recovery, partial recovery with complication, transfer to ICU and mortality. Chi Square test, Binominal Regression analysis and Receiver operator characteristic (ROC) curve analysis were performed as applicable. p value &lt;0.05 was considered as the level of significance. Results: The mean BISAP score among 107 study participants was 2.00 ± 0.76. Patients with BISAP score ³3 had significantly increased odds of prolonged hospital stay (OR: 11.226; 95% CI: 2.985- 42.222; p&lt;0.001), higher rate of partial recovery with complications (OR: 7.302; 95.325% CI: -20.997; p&lt;0.001). &lt;0.001), and greater likelihood of intensive care unit (ICU) transfer (OR: 1.136; 95% CI: 0.968-1.333; p=0.004). A BISAP score cutoff value of ³3 was associated with increased length of hospital stay (sensitivity 91.3%, specificity 97.6%, AUC=0.945), partial recovery with complications (sensitivity 83.3%, specificity 96.4%, AUC=0.899), and ICU transfer (sensitivity 75%, specificity 80.6%, AUC=0.778).Conclusion: It can be concluded that increased BISAP score can be served as an independent predictor of in-hospital in patients with acute pancreatitis (AP). Bangladesh J Medicine 2024; 35: 88-92
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Venkatapuram, Mahidhar Reddy, Sreeram Sateesh, and Deepthi Batchu. "A prospective study of BISAP score in assessing severity of acute pancreatitis." International Surgery Journal 5, no. 5 (2018): 1785. http://dx.doi.org/10.18203/2349-2902.isj20181571.

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Background: Aim of study is to prospectively evaluate the ability of the Bedside Index for Severity in Acute Pancreatitis (BISAP) score to predict mortality as well as intermediate markers of severity.Methods: 50 patients admitted from December 2015 to November 2017 with acute pancreatitis were included in the study. BISAP score is calculated in all such patients based on data obtained within 24hrs of hospitalization. Patients were assessed for organ failure according to Marshall scoring system and followed throughout hospitalization for assessment of complications. Statistical analyses were made using Fischer’s exact probability test. The difference was assumed statistically significant when p&lt;0.05.Results: There was a statistically highly significant trend for increasing mortality (p &lt; 0.05) and intermediate markers of severity (p&lt;0.05) that is transient organ failure, persistent organ failure and pancreatic necrosis with BISAP score ≥3.Conclusions: The BISAP score represents a simple way to identify patients at risk of increased mortality and the development of intermediate markers of severity within 24 hours of presentation.
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Mumin, Abdul, A. K. M. Shahriar Kabir, Rifat Ara Noor, Urmi Rahman, and Abdullah Al Amin. "Role of C- Reactive Protein (CRP) and Neutrophil Lymphocyte Ratio (NLR) in detecting severity & Predicting outcome of Acute Pancreatitis patients." Dinkum Journal of Medical Innovations 3, no. 01 (2024): 01–12. https://doi.org/10.71017/djmi.3.1.d-0236.

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Acute pancreatitis is an inflammatory disease with varied clinical course. It may vary from mild to severe. Early identification of potentially severe acute pancreatitis is of utmost importance. Acute pancreatitis patients with delayed transfer to intensive care have higher mortality. The severity of the illness can be assessed by some early clinical features, bed side scoring systems, or by the CT severity index. But all these have own disadvantages. So a single and cost effective laboratory test is desired to predict severity of the disease. This study determined the predicting value of C-reactive protein (CRP) and Neutrophil-Lymphocyte ratio (NLR) for the severity of acute pancreatitis of Acute Pancreatitis patients admitted in Chittagong Medical College Hospital. The study followed the observational cross-sectional study design where data has been collected from N=40 patient of department of medicine, Chittagong Medical College Hospital, Chattogram. After obtaining data from clinical examination and laboratory investigations the enrolled patients were grouped into mild and severe pancreatitis using BISAP score. Patients with BISAP score 3 or &gt;3 were grouped as severe and those who scored &lt;3 were grouped as mild pancreatitis. Then quantitative serum CRP and NLR values of each group measured and mean value of each group compared by Chi-square test. After that the values of both CRP and NLR were correlated with severity of acute pancreatitis according to BISAP score by correlation analysis. Finally a cutoff value of CRP and NLR were estimated for predicting severity of acute pancreatitis by receiver operating characteristic (ROC) curve analysis. According to the BISAP score patients of acute pancreatitis were distributed in mild to moderate and severe categories. Among them each categories were distributed according to the CRP level. The result found that most of the severe cases in BISAP score also had CRP level &gt;90 mg/L level (20%), which is statistically significant (P value &lt;0.05). It also found that majority of the mild to moderate cases in BISAP score had CRP level &lt;90 mg/L (72.5%), which is also statistically significant (P value &lt;0.05). The study revealed elevation of CRP and NLR both correlate with the number of BISAP score and thus severity of acute pancreatitis.
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EFGAN, Mehmet Göktuğ, Umut PAYZA, Osman Sezer ÇINAROĞLU, Ecem ERMETE GÜLER, and Ahmet KAYALI. "Akut pankreatitte şiddetin öngörülmesinde BUN/albümin oranı ile BISAP skorunun karşılaştırılması." Cukurova Medical Journal 48, no. 3 (2023): 1096–105. http://dx.doi.org/10.17826/cumj.1334913.

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Purpose: This study evaluated patients diagnosed with acute pancreatitis in the emergency department by comparing the BUN/Albumin Ratio (BAR) and BISAP scores to indicate disease severity and prognosis.&#x0D; Materials and Methods: 457 patients diagnosed with acute pancreatitis between 2016 and 2021 were included in this observational study, which was planned retrospectively. The laboratory data of the patients and the calculated BISAP scores were recorded. &#x0D; Results: Patients were categorized according to the BISAP score; 385 (84.2%) patients were at low risk for acute pancreatitis, while 72 (15.8%) were at high risk. The AUC for BAR values was 0.757 (75.7%), and this was statistically significant for determining cutoff values, with a cutoff value of &gt;4.60 (p
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Shivarajan, Dhamodhara Kannan, Dr Bhupendra Mehra, Dr Siddharth P. Dubhashi, and Dr Nitin Sherkar. "Critical Evaluation of BISAP Score in Assessing the Severity of Acute Pancreatitis: A Prospective Observational Study." International Journal of Innovative Research in Medical Science 9, no. 08 (2024): 463–68. http://dx.doi.org/10.23958/ijirms/vol09-i08/1938.

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Background: Early identification of patients at risk of mortality during acute pancreatitis is crucial for improving outcomes. Surgeons have long sought a clinical scoring system that is straightforward, easy to calculate using clinical parameters, and practical to apply. Aim: To evaluate the role of the BISAP scoring system in assessing the severity of acute pancreatitis. Settings and Design: Prospective observational study conducted in a tertiary care centre in central India from Jan 2023 to April 2024. Methods and Material: The study encompassed all patients diagnosed with acute pancreatitis. Within 24 hours of admission, the BISAP score was computed. Additionally, organ failure was assessed using the Marshall Scoring System. Results: Among 190 patients included in the study, there were 174 males and 16 females. The most common aetiology among men was alcoholism, while among women, it was gallstone disease. Of the total 190, 51 patients developed develop organ failure &amp; 18 patients died, with 16 of them having a BISAP score ≥3. The BISAP score demonstrated a sensitivity of 90.64% and a specificity of 84.3% for predicting organ failure. Additionally, it showed a positive predictive value of 94.02% and a negative predictive value of 76.7% in this regard. Conclusion: The BISAP score serves as a valuable tool for risk stratification and prognostic prediction in clinical practice. It is recognized for its simplicity and accuracy in identifying patients early who are at higher risk for mortality and morbidity during hospitalization.
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Huilca Herrera, Sharon Nathaly, and Fabian Gerardo Correa Martinez. "Comparación de la eficacia entre las escalas de APACHE II y BISAP como valores predictivos de la morbimortalidad en la pancreatitis aguda." Salud ConCiencia 2, no. 2 (2023): e38. http://dx.doi.org/10.55204/scc.v2i2.e38.

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Introducción: La pancreatitis aguda constituye un problema de salud a nivel mundial, es un proceso inflamatorio del páncreas con posible tejido peripancreático y que produce una afectación multiorgánica lo cual incrementa la tasa de mortalidad, así como eleva el costo en la atención a los pacientes que la padecen.&#x0D; Objetivo: Comparar las escalas de APACHE II Y BISAP como valores predictivos de la morbimortalidad en la pancreatitis aguda.&#x0D; Desarrollo: Los estudios muestran que las escalas APACHE II y BISAP pueden ser empleadas con buenos resultados para predecir la severidad de la PA, ya que excluyen muy bien a los casos negativos y pueden ser tratados de manera más sencilla sin el riesgo de complicaciones posteriores. Las imprecisiones en APACHE II las vinculan a que esta escala no fue creada inicialmente para PA, en cuanto a BISAP, a su sencillez y que incluyen una evaluación subjetiva del estatus mental del paciente que a veces tiene sus inconvenientes.&#x0D; Conclusiones: La escala APACHE II puede resultar más efectiva en muchos casos, pero también es más compleja y requiere de Imagenología y más ítems, mientras BISAP resulta más práctica, al incluir menos elementos.
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Aggarwal, Amulya, Alok V. Mathur, Ram K. Verma, Megha Gupta, and Dheeraj Raj. "Comparison of BISAP and Ranson’s score for predicting severe acute pancreatitis and establish the validity of BISAP score." International Surgery Journal 7, no. 5 (2020): 1473. http://dx.doi.org/10.18203/2349-2902.isj20201854.

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Background: Pancreatitis can lead to serious complications with severe morbidity and mortality. So an early, quick and accurate scoring system is necessary to stratify the patients according to their severity so as to enable early initiation of required management and care. Scoring system commonly used have some drawbacks. This study aimed to compare bedside index for severity in acute pancreatitis (BISAP) and Ranson’s score to predict severe acute pancreatitis and establish the validity of a simple and accurate clinical scoring system for stratifying patients.Methods: This is a prospective comparative study on 100 patients diagnosed with acute pancreatitis admitted in department of general surgery. Parameters included in the BISAP and Ranson’s criteria were studied at the time of admission and after 48 hours. Result of these two were compared with that of revised Atlanta classification.Results: As per the BISAP score, the sensitivity and specificity were 95.8 % (95% CI, 76.8-99.8), 94.7 % (95% CI, 86.3-98.3) whereas positive likelihood ratio, negative likelihood ratio 18.21 (95% CI, 6.9-47.44), 0.04 (95% CI, 0.01-0.30) and accuracy was 95 % (95% CI, 88.72%-98.36%). On using Ranson’s score, the sensitivity and specificity were 91.6 (95% CI, 71.5-98.5) and 89.4 (95% CI, 79.8-95) with a positive predictive value 8.71 (95% CI, 4.47-18.96) and negative predictive value of 0.09 (95% CI, 0.02-0.35) and accuracy of 90% (95% CI, 82.38%-95.10%)..Conclusions: BISAP score outperformed Ranson’s score in terms of Sensitivity and specificity of prediction of severe pancreatitis. The authors recommend inclusion of BISAP Scoring system in standard treatment protocol of management of acute pancreatitis.
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Bung, Yogesh Kumar, Chandrasekhar Sharanappa Neeralagi, Lakkanna Suggaiah, Usharani Rathnam, and Chandrakant Kesari. "A prospective study to predict the severity of acute pancreatitis by BISAP score." International Surgery Journal 4, no. 7 (2017): 2221. http://dx.doi.org/10.18203/2349-2902.isj20172770.

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Background: Acute pancreatitis (AP) is as an inflammation of the pancreas with varied range of complication like peri-pancreatic collection, pancreatic necrosis, renal failure, multi-organ dysfunction syndrome which increases mortality rate and morbidity. Majority of AP cases are mild but severe cases of AP are associated with increased complication and mortality. BISAP is simple bedside prognostic scoring system for predicting severity of AP. BISAP is a collection of simple routine investigation and scores are quantified at 24hours of onset of AP. This study aims to assess prognosis of AP cases at ESIC Medical college and Post Graduate Institute of Medical Science and Research, Bangalore, Karnataka, India.Methods: A prospective study of 60 Patients who were diagnosed as AP according to RAC. All patients were admitted in high dependency unit with close observation of vital parameters and investigations were done at 24 hours of onset of AP. BISAP score &gt;3 was considered as Severe Acute Pancreatitis, its correlation with local complications, organ failure, ICU stay and Mortality was studied. Statistical analysis done using Chi-square test and Fisher Exact test for local complications and organ failure using xL Stat and SPSS v.21.0, a p-value &lt;0.05 was considered to be significant.Results: Of the 60 patients, BISAP score was &gt;3 and &lt;3 in 15 and 45 patients respectively. Alcohol was the most common cause of acute pancreatitis, accounting for 53.33%. In current study 12 (20%) patients developed organ failure and among them 9 (75%) had transient organ failure and 3 (25%) had persistent organ failure. Total 8 (13%) patients had developed pancreatic necrosis and among them 6 had BISAP &gt;3. Mortality rate in this study was 2%.Conclusions: The BISAP score is a simple and fairly accurate method for the early identification of patients at increased risk for in hospital mortality and to identify patients at risk of the development of intermediate markers of severity and organ failure within 24 hours of presentation.
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ACEHAN, Selen, Salim SATAR, Müge GÜLEN, Basak TOPTAS FİRAT, Deniz AKA SATAR, and Adnan TAŞ. "65 yaş üstü hastalarda puanlama sistemlerinin şiddetli akut pankreatiti ve mortaliteyi erken öngörme açısından değerlendirilmesi." Cukurova Medical Journal 47, no. 3 (2022): 1327–38. http://dx.doi.org/10.17826/cumj.1121730.

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Purpose: The aim of this study is to investigate the power of disease severity scores to predict the development of Severe Acute Pancreatitis (SAP) and mortality in the early period over 65 years old diagnosed with acute pancreatitis in the emergency department. &#x0D; Materials and Methods: We calculated RANSON (on admission) and Computed Tomography Severity Index (CTSI) in addition to Bedside Index for Severity in Acute Pancreatitis (BISAP) score on admission to the emergency department.&#x0D; Results: One hundred and sixty patients (46.9% over 80 years of age) were included in the study. We observed statistically higher length of hospitalization, longer duration of stay in the intensive care unit, SAP and higher mortality in patients over 80 years of age. When we examined the ROC curve, we determined that the AUC values of the BISAP score were highest in both SAP and mortality estimation (AUC: 0.911, 95% CI 0.861-0.962; AUC: 0.918, 95% CI 0.864-0.9722, respectively). Binary logistic analysis indicated a 4.7-fold increased risk for SAP and a 12.3-fold increased mortality for each unit increase in BISAP score value.&#x0D; Conclusion: BISAP may be a good predictor for SAP and mortality estimation on admission to the emergency department in patients over 65 years of age with acute pancreatitis.
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Khattak, Muhammad Bilal, Rao Saad Ali Khan, Rao Zaid Ali Khan, et al. "Diagnostic Accuracy of Bedside Index for Severity in Acute Pancreatitis and Modified Computed Tomography Severity Index in Determining the Severity of Acute Pancreatitis using Revised Atlanta Classification as the Gold Standard." Pakistan Armed Forces Medical Journal 73, no. 3 (2023): 933–37. http://dx.doi.org/10.51253/pafmj.v73i3.9430.

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Objective: To determine the diagnostic accuracy of modified computed tomography severity index (CTSI) and Bedside index for severity in acute pancreatitis (BISAP) scoring system in predicting severity in acute pancreatitis, keeping the Revised Atlanta Classification (RAC) as the gold standard.&#x0D; Study Design: Prospective longitudinal study.&#x0D; Place and Duration of Study: Department of Gastroenterology, Pak Emirates Military Hospital, Rawalpindi Pakistan, Pakistan from Jan to Jul 2022.&#x0D; Methodology: This study was conducted on 100 patients with acute pancreatitis, both genders and ages. Patients with chronic pancreatitis, pancreatic calcifications, dilated pancreatic duct, areas of atrophy and pseudocysts were excluded. Detailed history and physical examination, and laboratory investigations were performed. Modified CTSI, BISAP and RAC were calculated. RAC was used as the gold standard. Sensitivity, specificity and other diagnostic parameters were calculated using R programme.&#x0D; Results: The mean age was 42.42±18.07 years. The males were 53%, and the females were 47%. CTSI was sensitive at 100%, specific at 58.43%, and overall diagnostic accuracy at 63%. BISAP was sensitive at 100%, specific at 68.54%, and overall diagnostic accuracy at 72%. &#x0D; Conclusion: BISAP and modified CTSI can assess severe acute pancreatitis (SAP) at primary and secondary care levels, enabling early triage and referral to higher centers.
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Malheiro, Filipa, Miguel Ângelo-Dias, Teresa Lopes, Sofia Azeredo-Lopes, Catarina Martins, and Luis Miguel Borrego. "B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity." Diseases 12, no. 1 (2024): 18. http://dx.doi.org/10.3390/diseases12010018.

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Acute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospitalization and 48 h after diagnosis. The Bedside Index of Severity in Acute Pancreatitis (BISAP) and length of hospital stay were also recorded. A healthy control (HC) group of 15 outpatients was included. AP patients showed higher neutrophil/lymphocyte (N/L) ratios and higher percentages of B cells than the HC group. The total B cell percentages were higher in patients with moderate/severe AP than in patients with mild AP. The percentages of B cells as well as the percentages of the CD27−IgD− B cell subset decreased from admission to 48 h after admission. The patients with higher BISAP scores showed lower percentages of peripheral lymphocytes but higher percentages of CD27−IgD− B cells. Higher BISAP scores, N/L ratios, and peripheral blood B cell levels emerged as predictors of hospital stay length in AP patients. Our findings underscore the importance of early markers for disease severity. Additionally, the N/L ratio along with the BISAP score and circulating B cell levels form a robust predictive model for hospital stay duration of AP patients.
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Mahajan, Ojas, Satish Mahajan, Sourya Acharya, et al. "A comparative evaluation of different scores in predicting severity and outcome in acute pancreatitis." F1000Research 12 (July 13, 2023): 824. http://dx.doi.org/10.12688/f1000research.133278.1.

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Background: Acute pancreatitis (AP) is an inflammatory condition usually caused by alcohol or gallstones. Our goal was to prospectively compare the diagnostic efficacy of the Acute Physiology &amp; Chronic Health Evaluation (APACHE) II, the Bedside Index of Severity in Acute Pancreatitis (BISAP), the Ranson's score &amp; the Modified Glasgow Score (MGS) in determining the severity &amp; outcome of Acute pancreatitis in a tertiary care facility in central India. Methods: Between December 2020 &amp; December 2022, this prospective observational study was done in rural area of Wardha district. 110 subjects were included, and the diagnosis of acute pancreatitis was done using Atlanta criteria. APACHE II, MGS, Ranson score on admission, Ranson score 48 hours after admission &amp; BISAP were used to evaluate each subject. The reciever operating curve was used to measure the specificity, sensitivity, NPV, PPV, diagnostic accuracy, area under the curve (AUC) &amp; these scoring methods were then prospectively compared. Results: When a cut-off based on the literature was used, the APACHE II score could accurately diagnose severe cases of AP (n=110) in 69 patients, BISAP in 68 patients, MGS in 49, Ranson score on admission in 48 patients &amp; after 48 hours in 48 patients. This study showed that Ranson score 48 hours after admission had a AUC (0.991), Ranson score at admission (AUC 0.989) &amp; Modified Glasgow Scale (AUC 0.6486) had fair accuracy as compared to APACHE II (AUC 0.974) &amp; BISAP (AUC 0.896) for determining the level of severity among AP patients based on ROC curves. Conclusion: To predict the severity of AP, the Ranson score after 48 hours showed the highest NPV, PPV, sensitivity, specificity, and diagnostic accuracy of all the scoring methods tested. The BISAP score had the highest specificity, sensitivity, PPV&amp; NPV for determining the outcome of AP.
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Авазов, Абдурахим Абдурахманович, Ёкубжон Эркин угли Хурсанов та Масрур Холмирзоевич Мухаммадиев. "ВОЗМОЖНОСТЬ ПРИМЕНЕНИЯ ИНТЕГРАЛЬНОЙ ШКАЛЫ BISAP ДЛЯ ПРОГНОЗИРОВАНИЯ РАЗВИТИЯ ТЯЖЕЛОГО ОСТРОГО ПАНКРЕАТИТА". Research Focus 1, № 2 (2022): 158–64. https://doi.org/10.5281/zenodo.7326046.

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<em>Данное исследование было проведено для оценки возможности использования шкалы BISAP в качестве независимого предиктора в развитии тяжелого острого панкреатита. Для этого были изучены следующие клинические и лабораторные параметры: уровень мочевины крови, наличие нарушение сознания, наличие SIRS (ССВР), возраст пациентов и наличие выпота в плевральной полости, которые были получены в течение первых 24 часов после госпитализации и до развития органной недостаточности. Была исследована взаимосвязь между полученными результатами оценки тяжести согласно шкале BISAP и развитием тяжелого острого панкреатита.</em>
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Coluoglu, I., E. Coluoglu, H. C. Binicier, and O. B. Binicier. "The role of the BISAP score in predicting acute pancreatitis severity according to the revised Atlanta classification: a single tertiary care unit experience from Turkey." Acta Gastro Enterologica Belgica 84, no. 4 (2021): 571–76. http://dx.doi.org/10.51821/84.4.007.

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Background/Aims: In this study, we examine the utility of Bedside Index of Severity in Acute Pancreatitis (BISAP), which is an increasingly more commonly used simple and practical novel scoring system for predicting the prognosis and severity of the disease at presentation. Materials and methods: Consecutive patients diagnosed with AP between January 2013 and December 2020 were evaluated retrospectively. The AP severity was assessed using the revised Atlanta classification (RAC). BISAP score, demographic characteristics, pancreatitis etiology, pancreatitis history, duration of hospital stay, and mortality rates of the patients were recorded. Results: A total of 1000 adult patients were included, of whom 589 (58.9%) were female and 411 (41.1%) were male. The mean age in female and male patients was 62.15 ± 17.79 and 58.1 ± 16.33 years, respectively (p &gt;0.05). The most common etiological factor was biliary AP (55.8%), followed by idiopathic AP (23%). Based on RAC, 389 (38.9%), 418 (41.8%), and 193 (19.3%) patients had mild, moderate, and severe AP. Of the 1000 patients, 42 (4.2%) died. Significant predictors of mortality included advanced age (&gt;65 y) (p=0.003), hypertension (p=0.007), and ischemic heart disease (p=0.001). A BISAP score of ≥3 had a sensitivity, specificity, positive predictive value, and negative predictive value (NPV) of 79.79%, 91.57%, 69.37%, and 94.99%, respectively, for determining SAP patients according to RAC. Conclusion: BISAP is an effective scoring system with a high NPV in predicting the severity of AP in the early course of the disease in a Turkish population.
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Pattanaik, S. K., V. Arvind Kumar, and Ajax John. "Comparison of bedside index of severity in acute pancreatitis (BISAP) and acute physiology and chronic health evaluation (APACHE II) score in assessing severity of acute pancreatitis." International Surgery Journal 4, no. 12 (2017): 4054. http://dx.doi.org/10.18203/2349-2902.isj20175409.

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Background: Acute Pancreatitis (AP) is one among the major diseases in the surgery wards with high rate of mortality. In spite of many scoring systems introduced to grade the severity of AP for optimal and timely management, mortality rate is still in a high pace. The aim of this study is to compare BISAP scoring system and APACHE II scoring system for accuracy and easiness in predicting the severity and mortality of AP and to deliver appropriate and timely intervention.Methods: The first 100 patients with AP in the year 2016 (January to August) were studied prospectively by calculating APACHE II score and BISAP score. According to Revised Atlanta classification severe AP was ascertained and the sensitivity and specificity of both scoring systems were assessed from chi square table. By using ROC curve accuracy and diagnostic value of two scoring systems were compared.Results: 100 patients with an age ranging from 20 to 80 years with a mean of 41.18 and male female ratio of 10.1:1 were studied. 95% of the patients presented with a symptom of abdominal pain and 49 out of 100 were having alcoholism as etiology. The average hospital stay of the patients was 12.03 days. Four patients died out of 11 severe AP and rest 89 were grouped into mild AP. BISAP score more than or equal to three have 64.2% chance of severe AP and was statistically significant in predicting the severity of AP. Areas under curve of the ROC curve after depicting the sensitivity and specificity of BISAP scores for severity and mortality were 0.90 and 0.96 respectively. APACHE II scores more than or equal to nine have 23.8% chance of severe AP and was statistically significant in predicting severity of AP. When sensitivity and specificity of APACHE II score were charted in ROC curve, areas under curve were 0.853 and 0.75 for severity and mortality in AP respectively.Conclusions: Compared to APACE II, BISAP is better scoring system in predicting both severity and mortality of AP on considering accuracy and easiness.
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Vijay, Kumar Shah1 Subodh Gautam2 Saharoj Siddiqui3 Ashmita Nepal4 Dipesh Kumar Gupta5. "BISAP Score as a Superior Predictor for Severe Acute Pancreatitis Compared to Ranson's Criteria: A cross sectional study." International Journal of Medical Science in Clinical Research and Review 7, no. 05 (2024): 1112–20. https://doi.org/10.5281/zenodo.13998231.

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<strong><u>ABSTRACT</u></strong><strong>:</strong> <strong>Background</strong>: Acute pancreatitis (AP) is an inflammatory condition of the pancreas characterized by activation of pancreatic enzymes to cause self-digestion of the pancreas, which presents as a mild upper abdominal discomfort with local inflammation to severe disease with multi-organ failure. It has a mortality of approximately 1% among all AP but it might be as high as 20% to 30% among those with severe acute pancreatitis (SAP). In clinical practice, accurate classification of the severity of acute pancreatitis is valuable in reducing mortality by clinical decision-making and action. The aim of this study is to compare the accuracy of BISAP scoring system and Ranson scoring system in predicting severity of acute pancreatitis. <strong>Methods: </strong>This is an observational, cross-sectional study conducted using a non-probability purposive sampling method. Result: A total of 25 patients with first episode of Acute Pancreatitis admitted were evaluated. <strong>Result</strong>: BISAP score of less than or equal to 3 predicted 93.75% of severe attacks and 83.3% of mild attacks with a PPV of 93.75% and NPV of 83.3% and accuracy of 90.09%.&nbsp; Ranson&rsquo;s score of greater than or equal to 4 predicted 42.8 % of severe attacks and 75 % of mild attacks with a positive predictive value of 33.33% and negative predictive value of 75% and accuracy of 60%. BISAP score has a better sensitivity, specificity, PPV, NPV and Accuracy than Ranson score in predicting the severity of AP putting the cutoff score &gt;3 for both the scoring systems. <strong>Conclusion:</strong> BISAP scoring system is very simple, cheap, easy to remember and calculate. It is instantaneous and there is no time delay in contrast to Ranson&rsquo;s score. It is also found to be superior to RANSON&rsquo;s score in predicting severity. <strong>&nbsp;</strong> <strong><em>Keywords: Acute Pancreatitis, Accuracy, BISAP score, Ranson Score, Severity</em></strong> &nbsp;
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Sehgal, Rishabh, Inder Pal Singh та Jyotisterna Mittal. "Clinical Profile and Outcome of Patients with Severe Acute Pancreatitis". Asian Journal of Medical Research 9, № 3 (2020): 8–11. http://dx.doi.org/10.47009/ajmr.2020.9.3.me2.

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Background: Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas leading to pancreatic autodigestion. The present study was conducted to study the clinical profile and outcome of patients with severe acute pancreatitis. Subjects &amp; Methods: The study was conducted on 40 patients of acute pancreatitis. Clinical profile including history, examination findings, etiology of pancreatitis, clinical severity (according to Modified Marshall Score, BISAP score, APACHE II, HAPS score, SOFA score) was recorded. Results: Severe Acute Pancreatitis (SAP) among patients. Majority of the patients i.e. 22 (55%) had alcohol consumption as etiological factor causing SAP followed by biliary 10 (25%) &amp; idiopathic 5 (12.5%). Hypertriglyceridemia and drug-induced (herbal medication) pancreatitis was present in 1 (2.5%) patient each. Out of all 1 (2.5%), patients had a history of both alcohol consumption and the presence of gallstone as an etiological factor. 22 patients (55%) out of 40 patients only conservative management was used while 18(45%) patients underwent USG guided percutaneous drainage was done. Out of these 18 patients, 3(7.5%) patients required Laparoscopic Necrosectomy &amp; 2(5%) patients required open necrosectomy in addition to ultrasound-guided PCD. Patients who improved had a mean BISAP SCORE of 2.15 0.54, Modified Marshall score of 3.65 1.44, APACHE II score of 9.77 4.45, SOFA score 5.54 2.49, RANSON’s score 3.85 1.80 and HAP score of 0.65 0.63. Conclusion: Most common etiology of severe acute pancreatitis is alcohol followed by biliary etiology. Out of severity scores (BISAP, APACHE-II, SOFA, HAPS), only BISAP score ≥3 is predictive of poor outcome in patients with severe acute pancreatitis.
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Kantly, Ramalingeshara, and Abhijit Medikeri. "Study on severity assessment of acute pancreatitis using BISAP score in rural area of south India." International Surgery Journal 5, no. 8 (2018): 2777. http://dx.doi.org/10.18203/2349-2902.isj20182997.

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Background: Acute Pancreatitis is one of the most common disease in all parts of INDIA. The morbidity and mortality of the disease can be reduced by early detection of complications. In rural health centres, authors need a simple and easily accessible and reproducible scoring system to access the severity. The main aim of the study is, using BISAP score authors can easily identify the severity and complications of acute pancreatitis as early as possible even in rural health centres.Methods: This is a prospective study conducted at Koppal District Hospital, Karnataka. Authors included 80 acute pancreatitis patients admitted in present hospital from July 2015 to July 2017. BISAP score is used within 24 hours of admission to access the severity and complications of the pancreatitis. Complications are accessed with respect to duration of hospital stay, organ failure and necrotising pancreatitis against BISAP score less than 3 and more than 3.Results: In present study male (83.75%) patients are more affected than females (16.25%). Alcohol (52.5%) being the main culprit then biliary (32.5%) and idiopathic (15%) as causes of acute pancreatitis. Middle age group between 30 to 50 years (66.25%) are more affected. Severe pancreatitis features like organ failure (66.67%) and necrotising pancreatitis (71.4%) are seen in patients with score more than 3. And also, the duration of inpatient hospital stay is longer (more than 5 day) in same patients.Conclusions: Acute pancreatitis is one of the most common causes for acute abdomen and alcohol consumption being the main culprit in rural areas of south India. Of the many scoring systems, BISAP score can be easily done at rural health centres to early detection of severity and complication of acute pancreatitis.
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Dr. Girish S.P. and Dr. Sainani Rahul Raju. "Clinical Prediction of outcomes in Acute Pancreatitis with Various Prognostic Indicators and Modified CTSI." IAR Journal of Medicine and Surgery Research 1, no. 3 (2020): 41–45. http://dx.doi.org/10.47310/iarjmsr.2020.v01i03.10.

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Introduction: Acute pancreatitis is the most common cause of patients presenting to the emergency department with pain abdomen. It is an inflammatory process of the pancreas that can range from mild inflammation to severe extensive pancreatic necrosis and multi-organ failure with mortality rates of 20% to 30%. Diagnosis can be difficult, because there is no pathognomic clinical presentation and no diagnostic gold standard. Material and Methods: It was a prospective cross-sectional descriptive study conducted in the Department of Gastroenterology at Sapthagiri Institute of Medical Sciences and Research Center from December 2019 – August 2020 among 100 patients. Results: The total patients studied in this study were 100, which comprises of 93 males and 7 females. Among the male population the maximum age group is 41-50. Next comes the 31-40 which includes 30 patients. Among the female population the maximum age group is 41-50 which includes about 4 patients. In our study distribution of the SAP within and above the cut off value of the different prognostic scores. 11 patients with SAP had RANSONs score &lt; 3 and 10 with SAP had RANSON score ≥ 3. 11 patients with SAP had APACHE II score of ≥8 whereas 10 had APACHE II score &lt; 8. But only 8 patients with SAP had BISAP score &lt; 3 and 13 SAP patients had BISAP score ≥ 3. MCTSI score in 11 SAP was &lt; 4 and 10 patients with MCTSI had ≥ 4. Conclusion: BISAP score is simple and it is the better scoring system in predicting the prognosis when compared to other scores &amp; MCTSI. BISAP score has many advantages when compared to other scoring systems.
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Lv, Yong-Cai, Yan-Hua Yao, Juan Zhang, Yu-Jie Wang, and Jing-Jing Lei. "Red cell distribution width: A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis." World Journal of Experimental Medicine 13, no. 5 (2023): 115–22. http://dx.doi.org/10.5493/wjem.v13.i5.115.

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BACKGROUND Compared with patients with other causes of acute pancreatitis, those with hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are more likely to develop persistent organ failure (POF). Therefore, recognizing the individuals at risk of developing POF early in the HTG-AP process is a vital for improving outcomes. Bedside index for severity in acute pancreatitis (BISAP), a simple parameter that is obtained 24 h after admission, is an ideal index to predict HTG-AP severity; however, the suboptimal sensitivity limits its clinical application. Hence, current clinical scoring systems and biochemical parameters are not sufficient for predicting HTG-AP severity. AIM To elucidate the early predictive value of red cell distribution width (RDW) for POF in HTG-AP. METHODS In total, 102 patients with HTG-AP were retrospectively enrolled. Demographic and clinical data, including RDW, were collected from all patients on admission. RESULTS Based on the Revised Atlanta Classification, 37 (33%) of 102 patients with HTG-AP were diagnosed with POF. On admission, RDW was significantly higher in patients with HTG-AP and POF than in those without POF (14.4% vs 12.5%, P &lt; 0.001). The receiver operating characteristic curve demonstrated a good discriminative power of RDW for POF with a cutoff of 13.1%, where the area under the curve (AUC), sensitivity, and specificity were 0.85, 82.4%, and 77.9%, respectively. When the RDW was ≥ 13.1% and one point was added to the original BISAP to obtain a new BISAP score, we achieved a higher AUC, sensitivity, and specificity of 0.89, 91.2%, and 67.6%, respectively. CONCLUSION RDW is a promising predictor of POF in patients with HTG-AP, and the addition of RDW can promote the sensitivity of BISAP.
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