Academic literature on the topic 'Bisindolylmaleimides'

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Journal articles on the topic "Bisindolylmaleimides"

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Barrett, Simon, Stephen Bartlett, Amanda Bolt, et al. "Configurational Stability of Bisindolylmaleimide Cyclophanes: From Conformers to the First Configurationally Stable, Atropisomeric Bisindolylmaleimides." Chemistry - A European Journal 11, no. 21 (2005): 6277–85. http://dx.doi.org/10.1002/chem.200500520.

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Bit, Rino A., Peter H. Crackett, William Harris, and Christopher H. Hill. "A convenient synthesis of bisindolylmaleimides." Tetrahedron Letters 34, no. 35 (1993): 5623–26. http://dx.doi.org/10.1016/s0040-4039(00)73899-8.

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Chiu, Ching-Wen, Tahsin J. Chow, Chang-Hao Chuen, Hsiu-Mei Lin, and Yu-Tai Tao. "Bisindolylmaleimides as Red Electroluminescence Materials." Chemistry of Materials 15, no. 23 (2003): 4527–32. http://dx.doi.org/10.1021/cm0303890.

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Wilkinson, S. E., P. J. Parker, and J. S. Nixon. "Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C." Biochemical Journal 294, no. 2 (1993): 335–37. http://dx.doi.org/10.1042/bj2940335.

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The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha, -beta, -gamma) and of a representative of the new, Ca(2+)-independent, PKC family, PKC-epsilon. In contrast with the indolocarbazole staurosporine, all the bisindolylmaleimides investigated showed slight selectivity for PKC-alpha over the other isoenzymes examined. In addition, bisindolylmaleimides bearing a conformationally restr
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Brenner, M. "Synthesis of arcyriarubin b and related bisindolylmaleimides." Tetrahedron 44, no. 10 (1988): 2883–86. http://dx.doi.org/10.1016/s0040-4020(01)96236-2.

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Brenner, Michael, Hans Rexhausen, Bert Steffan, and Wolfgang Steglich. "Synthesis of arcyriarubin b and related bisindolylmaleimides." Tetrahedron 44, no. 10 (1988): 2887–92. http://dx.doi.org/10.1016/s0040-4020(88)90025-7.

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BIT, R. A., P. H. CRACKETT, W. HARRIS, and C. H. HILL. "ChemInform Abstract: A Convenient Synthesis of Bisindolylmaleimides." ChemInform 24, no. 52 (2010): no. http://dx.doi.org/10.1002/chin.199352169.

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Mandl, Christian, Manfred Zabel, and Burkhard König. "Synthesis and Structure of New Macrocyclic Bisindolylmaleimides." Collection of Czechoslovak Chemical Communications 68, no. 5 (2003): 899–906. http://dx.doi.org/10.1135/cccc20030899.

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We report synthesis and structure of three new macrocyclic bisindolylmaleimides. The UV spectra of the xylene-bridged compounds4and6show significant differences. A dependence of the absorption properties on the maleimide-indole torsion angles is likely. A first attempt to use induced changes in ring conformation of the more flexible macrocyclic crown ether derivative8to signal the presence of metal cations failed.
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Faul, Margaret M., Leonard L. Winneroski, Christine A. Krumrich, et al. "Macrocyclic Bisindolylmaleimides: Synthesis by Inter- and Intramolecular Alkylation." Journal of Organic Chemistry 63, no. 6 (1998): 1961–73. http://dx.doi.org/10.1021/jo971980h.

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Faul, Margaret M., and Christine A. Krumrich. "Cyclization Strategies for the Synthesis of Macrocyclic Bisindolylmaleimides." Journal of Organic Chemistry 66, no. 6 (2001): 2024–33. http://dx.doi.org/10.1021/jo001605g.

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Dissertations / Theses on the topic "Bisindolylmaleimides"

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Bartlett, Stephen James. "Synthesis, conformational studies and biological activity of bisindolylmaleimide cyclophanes." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424060.

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Bühler, Sabrina [Verfasser]. "Einfluss von Bisindolylmaleimid-5 auf die Funktion ventrikulärer Kardiomyozyten und der post-ischämischen Funktionserholung des Herzens / Sabrina Bühler." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064838170/34.

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Humphrey, Peter Saah. "Signal transduction mechanisms for stem cell differentation into cardiomyocytes." Thesis, University of Hertfordshire, 2009. http://hdl.handle.net/2299/3760.

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Cardiovascular diseases are among the leading causes of death worldwide and particularly in the developed World. The search for new therapeutic approaches for improving the functions of the damaged heart is therefore a critical endeavour. Myocardial infarction, which can lead to heart failure, is associated with irreversible loss of functional cardiomyocytes. The loss of cardiomyocytes poses a major difficulty for treating the damaged heart since terminally differentiated cardiomyocytes have very limited regeneration potential. Currently, the only effective treatment for severe heart failure i
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Huang, Ding-Chi, and 黃鼎棋. "Synthesis and Characterization of Bichromophoric Molecules based on Dipyrazolopyridine and Bisindolylmaleimide." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/86196693490910104860.

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碩士<br>國立清華大學<br>化學系<br>95<br>A series of bichromophoric molecules (PAP-X-Red), are synthesized. The 3, 5 positions of PAP are modified by substitution groups of different sizes. The additivity of UV spectra of the two chromophores indicates no strong interaction between the chromophores in the ground state. Analysis of the excitation spectra suggests the occurrences of intramolecular energy transfer. According to QM calculation, the orientation between emission and absorption transition dipole of the two choromophores are almost perpendicular, but the energy transfer rate is still large d
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Παπαδημητρίου, Ευτυχία. "Ινδολοκαρβαζόλια : Σύνθεση και βιολογικές ιδιότητες". Thesis, 2014. http://hdl.handle.net/10889/8072.

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Τα ινδολοκαρβαζόλια είναι αλκαλοειδή και παρουσιάζουν ενα ευρύ φάσμα βιολογικών ιδιοτήτων, όπως αντιβακτηριακές, αντιμυκησιακές, αντιικές, υποτασικές, νευροπροστατευτικές ιδιότητες. Όμως η σημαντικότερη δράση τους είναι η αντικαρκινική. Η εργασία αυτή είναι ένα review των συνθετικών μεθόδων και των βιολογικών ιδιοτήτων των ινδολοκαρβαζολίων. Επίσης σχολιάζονται η βιοσύνθεσή τους, παράγωγες ενώσεις των ινδολοκαρβαζολίων αλλά και υποψήφια φάρμακα με δομή ινδοκαρβαζολίου.<br>Indolocarbazoles are alkaloids which display a wide range of biological properties including antibacterial, antifungal, hy
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Wen, Hui-Chun, and 溫慧鈞. "Part I :A study of Ro 31-8220, bisindolylmaleimide VIII and LY 379196 -induced PI3-kinase/Akt activation in epithelial cells. Part II:Regulatory roles of Ca2+ and ERK-mediated cPLA2 phosphorylation in arachidonic acid release in epithelial cells." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/60116603379290169759.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>88<br>Part I :A study of Ro 31-8220, bisindolylmaleimide VIII and LY 379196 -induced PI3-kinase/Akt activation in epithelial cells. The lipid kinase phosphoinositide 3-kinase (PI3K) and its target kinase Akt are involved in a variety of signal transduction and diverse cellular functions. Although substantial studies have begun to explore the regulation of PI3K/Akt cascade by different signaling pathways, whether protein kinase C (PKC) activity plays a crucial role remains as yet unclear. In this study, we found that PKC inhibitors Ro 31-8220, bisindolylmale
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Book chapters on the topic "Bisindolylmaleimides"

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Faul, Margaret M., John L. Grutsch, Michael E. Kobierski, et al. "Route Selection and Development for the Synthesis of N-(Azacycloalkyl) Bisindolylmaleimides: Selective Inhibitors of PKCβ." In 19th International Congress on Heterocyclic Chemistry. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50208-2.

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Conference papers on the topic "Bisindolylmaleimides"

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Li, Xiaochuan, Jiangshan Chen, Dongge Ma, Qiong Zhang, and He Tian. "Bisindolylmaleimides derivatives for effective EL materials." In Photonics Asia 2004, edited by Gang Yu, Chuangtian Chen, and Changhee Lee. SPIE, 2005. http://dx.doi.org/10.1117/12.600901.

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