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Academic literature on the topic 'Bixin'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Bixin"

1

Kurniawati, Pipin T., H. Soetjipto, and Leenawati Limantara. "ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF BIXIN PIGMENT FROM ANNATTO (Bixa orellana L.) SEEDS." Indonesian Journal of Chemistry 7, no. 1 (2010): 88–92. http://dx.doi.org/10.22146/ijc.21719.

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Research on Bixa orellana L. have been done to isolate, identify and determine bixin percentage, the antioxidant and antibacterial activities of bixin from B. orellana seed. Isolation and identification of bixin was done by thin layer chromatography (TLC), column chromatography, chemical test of bixin and UV-Vis double beam spectroscopy. Percentage of bixin was calculated by JECFA method, the antioxidant activity was determined by DPPH (1-1 diphynilpicrylhidrazil) method while antibacterial activity was analyzed by the use of agar diffusion method. Thin layer chromatography (TLC) for the crude extract contained 5 spot, where spot 5th was bixin. Bixa orellana has 75±3% of bixin. Antioxidant activity of bixin had IC50 548.5±20.0 ppm. Whereas the antibacterial activity of bixin against the Escherichia coli and Staphylococus aureus could be classified as weak inhibition category at 500-750 μg and medium inhibition category at 1500 μg. Keywords: Bixa orellana L., bixin, antioxidant, antibacteria
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2

Rahmalia, Winda, Septiani Septiani, Uray Amira Naselia, Thamrin Usman, Imelda Hotmarisi Silalahi, and Zéphirin Mouloungui. "Performance Improvements of Bixin and Metal-Bixin Complexes Sensitized Solar Cells by 1-Methyl-3-propylimidazolium Iodide in Electrolyte System." Indonesian Journal of Chemistry 21, no. 3 (2021): 669. http://dx.doi.org/10.22146/ijc.60633.

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Bixin is one of the potential natural sensitizers used in dye-sensitized solar cells (DSSCs). In this study, bixin was complexed with Cu(II) and Zn(II) to increase its stability. The formation of the complexes was indicated by shifting peaks absorption and the changes in the fine spectral structure observed from the UV-Vis absorption spectra. The metal-bixin complex occurs due to the interaction between the ester groups of bixin and the metal. Bixin, Cu-bixin, and Zn-bixin were used separately as sensitizers in DSSCs. The DSSCs performance was then improved by adding 1-methyl-3-propylimidazolium iodide (MPII) to the electrolyte system. The presence of MPII 0.4 M in KI-I2 electrolyte produced a higher ionic conductivity value (20.44 mS cm–1) than that without MPII (11.14 mS cm–1). This electrolyte system significantly improved DSSCs performance. Under a light intensity of 300 W/m2, the maximum energy conversion efficiencies of DSSC with bixin, Cu-bixin, and Zn-bixin as sensitizers are 0.084, 0.081, and 0.005%, respectively. The Zn-bixin-based DSSC was stable under high light intensity. Under 700 W/m2, its maximum energy conversion efficiency reaches 0.125%. There was a synergistic work observed between the metal-bixin complex and the MPII based electrolyte. This result can open the way for constructing functional materials for solar cell applications.
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3

Hadary, Ferry, Nelly Wahyuni, Syaifurrahman, and Ayong Hiendro. "High Photoabsorption and Photostability of Photosesitizers for Kaolinite-Bixin Solar Cells." Applied Mechanics and Materials 780 (July 2015): 7–15. http://dx.doi.org/10.4028/www.scientific.net/amm.780.7.

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Natural pigments have low photostability due to the nature of their molecular structures. The conjugated structures lead the pigment molecules to be degraded quickly by the UV radiation. In this work, bixin is used as natural pigments for photosensitizers. Kaolinite is employed as a barrier to protect the bixin from degradation. Impregnating bixin into kaolinite forms more stable molecular structures which improve photostability of the bixin. Moreover, kaolinite can serve as a carrier material which allows the transfer of electrons from bixin to kaolinite molecules through the hydrogen bonds that form between them. As results, kaolinite does not only slow down the bixin photodegradation rate, but also improve bixin photoabsorption capability
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4

Hoang, Chuyen V. "Effects of different extraction methods on the recovery yield of bixin from annatto seeds (Bixa orellana L.)." Journal of Agriculture and Development 18, no. 06 (2019): 58–65. http://dx.doi.org/10.52997/jad.8.06.2019.

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Bixin is a principal color component of annatto pigment which is obtained from the seed coat of Bixa orellana L., a tropical shrub. The extraction yield of bixin from annatto seeds using acetone, soybean oil and sodium hydroxide solution with different extraction conditions were investigated in this study. The extraction time, temperature, solid-liquid ratio and light exposure showed significant effects on the bixin yield. The extraction using soybean oil had the lowest bixin yield followed by the extraction using sodium hydroxide solution. The extraction using acetone resulted in the highest extraction yield (68.1%) after only 40 min. The extraction using soybean oil at 100oC led to two-fold bixin yield compared to that operated at 80oC while the mild temperature (50oC) was found to be the most suitable for the extraction using sodium hydroxide solution. The exclusion of light exposure by covering extraction beakers with aluminum foil could significantly improve the bixin extraction yield due to the reduction in bixin degradation. Therefore, the extraction using acetone avoiding light exposure is suggested for recovering bixin from annatto seeds.
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5

Masrullita, Masrullita, Novi Yanti Savira, Rizka Nurlaila, and Lukman Hakim. "PEMBUATAN ZAT WARNA ALAMI DARI BIJI KESUMBA (BIXA ORELLANA) UNTUK MENDUKUNG INDUSTRI BATIK DI INDONESIA." Jurnal Teknologi Kimia Unimal 8, no. 1 (2021): 33. http://dx.doi.org/10.29103/jtku.v10i1.4174.

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Bixin merupakan pewarna alami kain yang didapatkan melalui ekstraksi dari biji kesumba (bixa orellana) dengan komponen pewarna utamanya adalah bixin. Penelitian ini bertujuan untuk pembuatan zat warna alami dari biji kesumba dengan variasi konsentrasi pelaut etanol dan waktu ekstraksi. Penelitian ini dilakukan dengan cara biji kesumba dijemur pada panas matahari hingga kering dan memecah biji buah kesumba dengan ukuran 80 mesh kemudian diekstraksi dan didistilasi. Hasil yang didapatkan dari penelitan ini adalah Semakin tinggi suhu maka kadar bixin yang dihasilkan semakin sedikit, hal ini disebabkan terjadinya degradasi pada senyawa bixin menjadi norbixin. Yield tertinggi yang didapatkan senilai 0,6366%, kadar bixin 165,9751% dan kadar abu 1,78%. Hasil terbaik yang didapatkan untuk kada abu adalah terdapat pada konsentrasi etanol 90% dan suhu ekstraksi 70oC dan 80oC dengan nilai 0,92% hal ini memenuhi spesifikasi yang diinginkan pasaran dunia terhadap pewarna alami, sedangkan untuk kada bixin yang tertinggi didapatkan pada konsentrasi etanol 70% pada suhu 600C, 700C, 800C dan juga pada konsentrasi etanol 80% pada suhu ekstraksi 600C dengan senilai 165,9751%.
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6

Pacheco, Samanta Daliana Golin, Alexia Thamara Gasparin, Carlos Henrique Alves Jesus, et al. "Antinociceptive and Anti-Inflammatory Effects of Bixin, a Carotenoid Extracted from the Seeds of Bixa orellana." Planta Medica 85, no. 16 (2019): 1216–24. http://dx.doi.org/10.1055/a-1008-1238.

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AbstractBixin is the main natural apocarotenoid extracted from the seeds of Bixa orellana, widely used as a cosmetic and textile colorant. Despite the description of several pharmacological properties of B. orellana extracts, little has been studied regarding the pharmacological properties of bixin. Then we aimed to investigate the potential anti-inflammatory and antinociceptive effect of bixin in preclinical models of inflammation and acute pain. The anti-inflammatory activity of bixin (15 or 30 mg/kg, orally) was determined using carrageenan-induced paw edema and the myeloperoxidase (MPO) activity in male Wistar rats. The antinociceptive effect of bixin was assessed in the formalin and hot plate tests in rats (at same doses) and in the acetic acid-induced writhing test in Swiss albino male mice (at doses of 27 or 53 mg/kg). General locomotor activity was evaluated in the open field test. Only the higher dose of bixin significantly decreased the carrageenan-induced paw edema and the MPO activity and increased the latency time in the hot plate. Both doses of bixin significantly reduced the number of flinches in both phases of the formalin test and the number of acetic acid-induced writhings without changing the locomotor performance in the open field test. This study validates the use of bixin as an anti-inflammatory trough mechanism related to the reduction of neutrophil migration. Furthermore, this is the first report showing the antinociceptive property of bixin, which does not appear to be related to the sedative effect. Further studies are necessary to characterize the mechanisms involved in these effects.
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7

Tao, Shasha, Youjing Yang, Jianzhong Li, Hongyan Wang та Yu Ma. "Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARα Signals". Oxidative Medicine and Cellular Longevity 2021 (2 лютого 2021): 1–17. http://dx.doi.org/10.1155/2021/6610124.

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Nonalcoholic fatty liver disease is the most common liver disease worldwide. Hepatic steatosis and oxidative stress are the main characteristics of NAFLD (nonalcoholic fatty liver disease), which also affect its prognosis. Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo. Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression. In human liver cells exposed to FFA (free fatty acid), bixin displayed a pronounced cytoprotective activity with upregulation of Nrf2-mediated gene expression, such as PPARα and its targets related with fatty acid oxidation. In HFD-fed mice, systemic administration of bixin attenuated lipid accumulation, decreased oxidant inflammatory damage in the liver, and reduced circulating lipid levels through Nrf2. Different from most of other established inducers, bixin activated Nrf2 signals through two different mechanisms with safe administration for protection of oxidant inflammatory damage and attenuation of lipid accumulation in the in vivo long-term HFD-fed mice. Bixin represents a prototype Nrf2 activator that displays cytoprotective activity upon system administration targeting hepatic steatosis and oxidant inflammation originating from long-term HFD-fed mice. And bixin-based Nrf2-directed systemic intervention may also provide therapeutic benefit in protecting other organs in the process of metabolic syndrome.
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8

Santos, GC, MR Almeida, LMG Antunes, and MLP Bianchi. "Effect of bixin on DNA damage and cell death induced by doxorubicin in HL60 cell line." Human & Experimental Toxicology 35, no. 12 (2016): 1319–27. http://dx.doi.org/10.1177/0960327116630352.

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Bixin is a natural red pigment extracted from annatto. Although it is widely used as a coloring agent in food, there are few studies about the effect of this carotenoid on DNA. This study aimed to investigate the effects of bixin on cytotoxicity and genotoxicity induced by doxorubicin in HL60 cells. At concentrations above 0.3 μg/mL, bixin demonstrated cytotoxic effects in HL60 cells. Furthermore, this carotenoid was neither mutagenic nor genotoxic to HL60 cells and reduced the DNA damage induced by doxorubicin. Bixin and doxorubicin showed no apoptotic effect in HL60 cells, but the simultaneous combined treatments showed an increase in the percentage of apoptotic cells. In conclusion, our results showed that bixin modulates the cytotoxicity of doxorubicin via induction of apoptosis. The results of this study provide more knowledge about the toxic effects of anticancer treatments and how the natural compounds can be useful on these therapeutic approaches.
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9

Souza, Lucéia Fátima, Niara da Silva Medeiros, Paula Cilene Pereira dos Santos, et al. "Antioxidants from Annatto Seeds as Possible Inhibitory Agents of the Hepatotoxicity Induced by the Antitumor Agent Cisplatin." Natural Product Communications 11, no. 9 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100909.

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The effects of annatto seeds and of bixin on the oxidative damage induced by cisplatin in male Wistar rats was evaluated in the present study by way of lipid peroxidation, weight gain, the food efficiency coefficient, fat deposits in the hepatocytes and dosing of the enzymes in this organ. The animals were divided into four groups: control group (CG), cisplatin group (CPG), bixin+cisplatin group (CBG) and annatto+cisplatin group (CUG). Cisplatin (5 mg/kg body weight) was injected intraperitoneally 48 hours before the end of the experiment. The bixin and annatto were administered daily together with the commercial feed. The pre-treatment with annatto and bixin attenuated the cisplatin-induced liver damage and significantly reduced the enzymes AST and ALT. Annatto was shown to be capable of inhibiting lipid peroxidation as determined by TBARS. These results suggest that annatto seeds and bixin could be important agents in the reduction of cisplatin-induced hepatotoxicity.
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10

Carballo-Uicab, Victor Manuel, Yair Cárdenas-Conejo, Alba Adriana Vallejo-Cardona, et al. "Isolation and functional characterization of two dioxygenasese putatively involved in bixin biosynthesis in annatto (Bixa orellana L.)." PeerJ 7 (June 21, 2019): e7064. http://dx.doi.org/10.7717/peerj.7064.

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Carotenoid cleavage dioxygenases (CCDs) are enzymes that have been implicated in the biosynthesis of a wide diversity of secondary metabolites with important economic value, including bixin. Bixin is the second most used pigment in the world’s food industry worldwide, and its main source is the aril of achiote (Bixa orellana L.) seeds. A recent transcriptome analysis of B. orellana identified a new set of eight CCD members (BoCCD4s and BoCCD1s) potentially involved in bixin synthesis. We used several approaches in order to discriminate the best candidates with CCDs genes. A reverse transcription-PCR (RT-qPCR) expression analysis was carried out in five developmental stages of two accessions of B. orellana seeds with different bixin contents: (P13W, low bixin producer and N4P, high bixin producer). The results showed that three BoCCDs (BoCCD4-1, BoCCD4-3, and BoCCD1-1) had an expression pattern consistent with bixin accumulation during seed development. Additionally, an alignment of the CCD enzyme family and homology models of proteins were generated to verify whether the newly proposed CCD enzymes were bona fide CCDs. The study confirmed that these three enzymes were well-preserved and belonged to the CCD family. In a second selection round, the three CCD genes were analyzed by in situ RT-qPCR in seed tissue. Results indicated that BoCCD4-3 and BoCCD1-1 exhibited tissue-specific expressions in the seed aril. To test whether the two selected CCDs had enzymatic activity, they were expressed in Escherichia coli; activity was determined by identifying their products in the crude extract using UHPLC-ESI-QTOF-MS/MS. The cleavage product (bixin aldehyde) was also analyzed by Fourier transform infrared. The results indicated that both BoCCD4-3 and BoCCD1-1 cleave lycopene in vitro at 5,6-5′,6′.
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