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1
Haddock, Shelley A. "A Conversation with Evan Imber-Black, PhD." Journal of Feminist Family Therapy 12, no. 4 (2001): 239–42. http://dx.doi.org/10.1300/j086v12n04_03.
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McGee, Ebony O., Devin T. White, Akailah T. Jenkins, et al. "Black engineering students’ motivation for PhD attainment: passion plus purpose." Journal for Multicultural Education 10, no. 2 (2016): 167–93. http://dx.doi.org/10.1108/jme-01-2016-0007.
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Purpose Much of the extant research, practice and policy in engineering education has focused on the limited persistence, waning interest and lack of preparation among Black students to continue beyond the post-secondary engineering pipeline. However, this research suggests that many Black PhD students persist and succeed in engineering, fueled by various motivational strengths. To better understand the motivations of Black students in engineering doctoral programs, this study aims to explore the factors that influence their decision to enroll in either an engineering or a computing doctoral program. Design/methodology/approach This paper uses an intrinsic and extrinsic motivational framework to investigate the inspiration of 44 Black engineering doctoral students in PhD engineering programs in 11 engineering schools across the country. Findings Results show that the participants’ motivation to pursue a PhD in engineering comes from several distinct factors, including the following: an unyielding passion for their particular discipline, a sense of responsibility to serve marginalized peoples and society, a path toward autonomy, pre-PhD mentorship and research opportunities and family and prior work experience. Research limitations/implications Based on this study’s findings, a reconceptualization of graduate engineering education that incorporates the importance of “being Black” and its relationships with motivating and, potentially, retaining Black science, technology, engineering and mathematics (STEM) students is also offered. Originality/value This paper seeks to expose particular constructs and behaviors surrounding Black students’ motivation to learn and achieve in engineering at the highest academic levels, offering a more nuanced perspective than currently is found in traditional engineering education literature.
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Price, Gregory N. "The Kerner Commission Report: Did It Incentivize or Cause an Increase in the Production and Hiring of Black PhD Economists in Academia?" Review of Black Political Economy 46, no. 4 (2019): 349–61. http://dx.doi.org/10.1177/0034644619857729.
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Approximately 50 years ago, the Kerner Commission Report cited pervasive racial discrimination in training, education, and employment as a contributor to Black–White inequality and stratification in the United States. This article considers if the Kerner Commission Report incentivized and possibly caused an increase in the production and hiring of Black PhD economists in academia. With longitudinal data on counts of economic doctorates earned by Black Americans employed in economics departments between 1957 and 2018, we estimate the parameters of count data specifications that accounts for the 1968 Kerner Commission Report dichotomously. Parameter estimates from mixed and fixed effect Poisson, negative binomial, and Poisson quantile specifications suggest that while the Kerner Commission Report generally had a positive effect on the number of Black American economics doctorates employed as faculty, it had no effect on the hiring of Black economists at the typical research institution and PhD-granting economics department. Our results suggest that similar to the Kerner Commission Report characterization of the United States being two separate racially stratified societies, approximately 50 years later research institutions and PhD-granting economics departments in the United States are similarly racially stratified.
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McCoy, Henrika. "What Do You Call a Black Woman With a PhD? A N*****: How Race Trumps Education No Matter What." Race and Justice 11, no. 3 (2021): 318–27. http://dx.doi.org/10.1177/2153368720988892.
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The 16-year journey from being a doctoral student to a tenured Associate Professor as a Black woman has been eventful. This essay provides a peek into some of the unforgettable moments experienced by one Black female PhD during that journey. It highlights how having a PhD as a Black woman has not resulted in the same respect and reverence generally afforded to those who are White. It reminds us of the work that still needs to be done if we are ever going to be able to honestly say that the playing field is even. It is also a story of resolve and commitment, and how it can be possible to find new ways to contribute to improving outcomes for Black people, even when current events make doing so seem impossible.
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Gines, Kathryn T. "Being a Black Woman Philosopher: Reflections on Founding the Collegium of Black Women Philosophers." Hypatia 26, no. 2 (2011): 429–37. http://dx.doi.org/10.1111/j.1527-2001.2011.01172.x.
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Although the American Philosophical Association has more than 11,000 members, there are still fewer than 125 Black philosophers in the United States, including fewer than thirty Black women holding a PhD in philosophy and working in a philosophy department in the academy.1The following is a “musing” about how I became one of them and how I have sought to create a positive philosophical space for all of us.
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Ehrenberg, Ronald G., George H. Jakubson, Jeffrey A. Groen, Eric So, and Joseph Price. "Inside the Black Box of Doctoral Education: What Program Characteristics Influence Doctoral Students’ Attrition and Graduation Probabilities?" Educational Evaluation and Policy Analysis 29, no. 2 (2007): 134–50. http://dx.doi.org/10.3102/0162373707301707.
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The Andrew W. Mellon Foundation’s Graduate Education Initiative (GEI) provided funding to 54 departments in the humanities and related social sciences during the 1990s to improve their PhD programs. This article estimates the aspects of PhD programs the GEI influenced and how these aspects influenced attrition and graduation probabilities. It uses survey data on entrants to PhD programs at 44 of the “treatment” departments and 41 “control” departments during a 15-year period that spanned the start of the GEI. Factor analysis is used to group more than 100 program characteristics into a smaller number of factors, and the impact of the GEI on each and the impact of each on attrition and graduation probabilities are estimated. The article estimates the routes via which the GEI influenced attrition and graduation rates and indicates which aspects of PhD programs departments should concentrate on to improve their programs’ performance.
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Betsey, Charles L. "African Americans in Economics at the University of Michigan-Ann Arbor Since the Kerner Commission Report of 1968." Review of Black Political Economy 46, no. 4 (2019): 379–98. http://dx.doi.org/10.1177/0034644619880562.
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The campus of the University of Michigan experienced student unrest of the 1960s surrounding the Vietnam war and demands for racial inclusion. How the university, particularly the Department of Economics, responded in the aftermath of the Kerner Commission Report is the focus of this article. Michigan is not unique in producing few Black PhD economists over its history, having graduated 15 Black PhD economists of the more than 1,100 who have graduated from the department to date. Supreme Court decisions and a state ballot initiative halted the progress that was being made by the University to improve student and faculty diversity. Despite this, Michigan is one of only a few economics departments at majority institutions to have been home to several Black economists simultaneously. The fact that this is a notable statistic speaks to the lack of diversity of economics faculties nationwide.
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M., Dmitrenok, and Pakul P. "History of Black Stork study in Belarus." Proceedings of the State Natural History Museum Vol. 33, no. 33 (August 10, 2017): 57–64. http://dx.doi.org/10.36885/nzdpm.2017.33.57-64.
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The Black Stork is well known, but still insufficiently studied species of birds in Belarus. The black stork in Belarus is well known, but still insufficiently studied species of birds. This article presents the analysis of literary sources. Mention of this species in the fauna of Belarus is from the 18 century. It was studied by several generations of scientists, zoologists, was awarded a PhD. Now the study of Black Stork continues with the application of new research methods that give more reliable results.
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Ecton, Walter G., Christopher T. Bennett, H. Kenny Nienhusser, Milagros Castillo-Montoya, and Shaun M. Dougherty. "If You Fund Them, Will They Come? Implications From a PhD Fellowship Program on Racial/Ethnic Student Diversity." AERA Open 7 (January 2021): 233285842110404. http://dx.doi.org/10.1177/23328584211040485.
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Prior research demonstrates the important role that financial considerations play in prospective students’ decision making when applying to and enrolling in graduate school. Racially/ethnically minoritized students, in particular, face persistent challenges during the graduate application and enrollment process. Capitalizing on a natural experiment, we identify the effects of introducing a PhD fellowship on the composition of applicants and enrolling students in PhD programs at a large public university’s graduate school of education. Using administrative data from 9 years of applications, we use difference-in-differences and event study analyses to show that the fellowship increased the number of applicants overall, as well as the share of Black applicants and enrollees in impacted cohorts, with no significant effects on academic preparation. To better understand why and how a PhD fellowship might impact students’ application behaviors and experiences once in graduate school, we supplement our primary findings with survey responses from current PhD students at the graduate school of education.
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Adida, Claire L., David A. Lake, Fatemeh Shafiei, and Matthew Platt. "Broadening the PhD Pipeline: A Summer Research Program for HBCU Students." PS: Political Science & Politics 53, no. 4 (2020): 723–28. http://dx.doi.org/10.1017/s1049096520000542.
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ABSTRACTThis article introduces, describes, and evaluates a program designed to broaden the PhD pipeline in political science to achieve greater equity and inclusion. In its fifth year, the program brings undergraduate students from two Historically Black Colleges and Universities to an R-1 political science PhD department for a seven-week summer program, in which they are paired with a faculty mentor to conduct research for, prepare, and present an original research project. Additionally, participants attend methods classes, GRE preparatory workshops, subfield presentations from graduate students and faculty in the host department, and social events. We describe key lessons drawn from our experience in piloting this program. We evaluate its success using data about the composition of the host institution’s PhD program and exit surveys conducted with all participants from 2016 to 2018.
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Reid-Merritt, Patricia. "Temple University’s African American Studies PhD Program @ 30: Assessing the Asante Affect." Journal of Black Studies 49, no. 6 (2018): 559–75. http://dx.doi.org/10.1177/0021934718786221.
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Temple University’s Department of Africology and African American Studies is celebrating its 30th year of operation as a PhD program. Since its inception in l988, the doctoral program at Temple has attracted and produced world-class scholars in the discipline of Africology. Initially started by students at San Francisco State University in l968 as Black Studies, the field has been called by many names, including Afro-American Studies, African American Studies, African World Studies, Africana Studies, Pan African Studies, and Africology. As this modern-day field of study marks its 50th anniversary, it is important that we examine the impact of the 30-year history of the establishment of the first PhD program in Black Studies in the nation, founded at Temple University in the City of Philadelphia. This article offers a preliminary assessment of the far-reaching impact of Temple’s academic leadership in establishing a fundamental base for innovative scholarship and the maturing of the discipline of Africology. More specifically, it focuses on Molefi Kete Asante’s influence, his vision for the discipline, and his extraordinary impact on the field of Africology.
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Darity, W., and A. Kreeger. "The Desegregation of an Elite Economics Department's PhD Program: Black Americans at MIT." History of Political Economy 46, Supplement 1 (2014): 317–36. http://dx.doi.org/10.1215/00182702-2716217.
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Lee, Seungyeon. "Academic Work and Leadership as a Black Woman: Interview With Loretta McGregor, PhD." Eye on Psi Chi Magazine 25, no. 3 (2021): 10–12. http://dx.doi.org/10.24839/2164-9812.eye25.3.10.
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Yunita, Roza, and Siti Nurhidayah. "Morphology Performance On Six Black Rice Accessions (Oryza Sativa L.) In M1 Generation Irradiated By Gamma Rays." JERAMI Indonesian Journal of Crop Science 3, no. 2 (2021): 62–67. http://dx.doi.org/10.25077/jijcs.3.2.62-67.2021.
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Increasing the genetic diversity of plants can be done through physical mutations with gamma-ray irradiation. This study aims to determine gamma-ray irradiation on the growth of six M1 generation black rice accessions. This research was conducted in May-October 2019 at the Experimental Rice Fields of the Tasikmalaya Perjuangan University, West Java. The materials used in this study were six accessions from Tasikmalaya (PH, PH2, PH3, PH5, PH7, and PH8) without 0 Gy irradiation and with 200 Gy gamma-ray irradiation of M1 generation. The results showed that gamma-ray irradiation reduced germination characteristics, seedling height, and flowering age. Some of the accessions showed different effects; there were a decrease and an increase in the characters of root length, plant height, number of productive tillers, number of unproductive tillers, and the total number of tillers.
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Adeniyi-Ogunyankin, Grace, Moya Bailey, Karen Flynn, et al. "Black Feminist Thought and the Gender, Women's, and Feminist Studies PhD: A Roundtable Discussion." Feminist Formations 32, no. 2 (2020): 1–28. http://dx.doi.org/10.1353/ff.2020.0023.
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Torche, Florencia. "Intergenerational Mobility at the Top of the Educational Distribution." Sociology of Education 91, no. 4 (2018): 266–89. http://dx.doi.org/10.1177/0038040718801812.
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Research has shown that intergenerational mobility is higher among individuals with a college degree than those with lower levels of schooling. However, mobility declines among graduate degree holders. This finding questions the meritocratic power of higher education. Prior research has been hampered, however, by the small samples of advanced degree holders in representative surveys. Drawing on a large longitudinal data set of PhD holders—the Survey of Doctorate Recipients—this study examines intergenerational mobility among the American educational elite, separately for men and women and different racial/ethnic groups. Results show substantial mobility among PhD holders. The association between parents’ education and adult children’s earnings is moderate among men and nonexistent among women with doctoral degrees. However, women’s earnings converge to an average level that is much lower than men’s, signaling ‘‘perverse openness’’ for women even at the top of the educational distribution. Among men, there is variation in mobility by race and ethnicity. The intergenerational socioeconomic association is null for Asian men, small for white and black men, and more pronounced for Hispanics. Educational and occupational mediators account for intergenerational association among blacks and whites but not Hispanic men. A doctoral degree largely detaches individuals from their social origins in the United States, but it does not eliminate all sources of inequality.
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Moore, Amber. "“Blackboxing it”: A Poetic Min/d/ing the Gap of an Imposter Experience in Academia." Art/Research International: A Transdisciplinary Journal 3, no. 1 (2018): 30–52. http://dx.doi.org/10.18432/ari29358.
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Entering academia is a journey often fraught with many intense emotions, including shame, self-doubt, and fear. As such, this exploratory paper aims to expose and “dwell poetically” (James, 2009) on such feelings of novice academics, particularly the “imposter syndrome” experience, through an act of creative vulnerability and meaning making. Employing critical poetic inquiry, this paper offers and examines found poetry mined from a first year language and literacy education PhD student’s early academic writing. This poetry writing was done while simultaneously “minding the gap” existing in the “black box” of the PhD experience (Stanley, 2015), and framed through the lenses of the “personal” as “political” (Hanisch, 2000) and shame resilience theory (Brown, 2006), resulting in a poetry “cluster” (Butler-Kisber & Stewart, 2009) that “speaks shame” (Brown, 2006), composed with the aim to invite comfort, connection, and community, particularly with emerging scholars.
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Kaatz, Anna, Molly Carnes, Belinda Gutierrez, et al. "Fair Play: A Study of Scientific Workforce Trainers’ Experience Playing an Educational Video Game about Racial Bias." CBE—Life Sciences Education 16, no. 2 (2017): ar27. http://dx.doi.org/10.1187/cbe.15-06-0140.
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Explicit racial bias has decreased in the United States, but racial stereotypes still exist and conspire in multiple ways to perpetuate the underparticipation of Blacks in science careers. Capitalizing on the potential effectiveness of role-playing video games to promote the type of active learning required to increase awareness of and reduce subtle racial bias, we developed the video game Fair Play, in which players take on the role of Jamal, a Black male graduate student in science, who experiences discrimination in his PhD program. We describe a mixed-methods evaluation of the experience of scientific workforce trainers who played Fair Play at the National Institutes of Health Division of Training Workforce Development and Diversity program directors’ meeting in 2013 (n = 47; 76% female, n = 34; 53% nonwhite, n = 26). The evaluation findings suggest that Fair Play can promote perspective taking and increase bias literacy, which are steps toward reducing racial bias and affording Blacks equal opportunities to excel in science.
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Kornyychuk, Yu M. "To the 125th anniversary of Vladimir Vodyanitsky." Marine Biological Journal 3, no. 1 (2018): 76–78. http://dx.doi.org/10.21072/mbj.2018.03.1.09.
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This year the 125th birthday of the outstanding hydrobiologist, D. Sc. (Biol.), Professor Vladimir Vodyanitsky is celebrated. Under his leadership, the Sevastopol Biological Station became a research institute significant for world science. He headed expeditions to Black, Mediterranean and Red seas. More then 30 PhD theses were defended under the guidance of Vladimir Vodyanitsky. He was the author of more than 160 publications and the editor of more than 60 monographs and collections of scientific papers.
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Karenga, Maulana. "Founding the First PhD in Black Studies: A Sankofa Remembrance and Critical Assessment of Its Significance." Journal of Black Studies 49, no. 6 (2018): 576–603. http://dx.doi.org/10.1177/0021934718797317.
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Clearly, the founding of the first PhD program in Black Studies at Temple University under the leadership of Molefi Kete Asante is a major, defining, and transformative achievement in the advancement of the discipline and in the discipline’s continuous initiatives and struggles to expand intellectual and institutional space for a truly multicultural, global, and quality education beyond the existing dominant monocultural Eurocentric paradigm and practice. Its significance also lies in the Afrocentric culturally grounded, agency-focused, and transformative discourse and practice the program has engendered beyond the academy, and the seminal contribution it has made to grounding and cultivating generations of activist intellectuals and scholars who play and will continue to play generative and transformative roles in the academy, their communities, and their societies in this country and in the world. The governing interest of this essay is to critically assess the transformative significance of this historic achievement. Beginning with an introduction to the issue and an examination of the sociohistorical and intellectual context out of which this achievement emerged and grounded itself, the essay, then, discusses some salient factors that define its transformative significance. It concludes with a discussion of sustaining and expanding that achievement in the context of sustaining and advancing the Black Studies project, while maintaining the discipline’s founding emancipatory and transformative mission.
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Sugahara, Mai, Shinji Tanaka, Tetsuhiro Tanaka, et al. "Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice." Journal of the American Society of Nephrology 31, no. 3 (2020): 560–77. http://dx.doi.org/10.1681/asn.2019060582.
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BackgroundProlyl hydroxylase domain (PHD) inhibitors, which stimulate erythropoietin production through the activation of hypoxia-inducible factor (HIF), are novel therapeutic agents used for treating renal anemia. Several PHD inhibitors, including enarodustat, are currently undergoing phase 2 or phase 3 clinical trials. Because HIF regulates a broad spectrum of genes, PHD inhibitors are expected to have other effects in addition to erythropoiesis, such as protection against metabolic disorders. However, whether such beneficial effects would extend to metabolic disorder–related kidney disease is largely unknown.MethodsWe administered enarodustat or vehicle without enarodustat in feed to diabetic black and tan brachyury (BTBR) ob/ob mice from 4 to 22 weeks of age. To elucidate molecular changes induced by enarodustat, we performed transcriptome analysis of isolated glomeruli and in vitro experiments using murine mesangial cells.ResultsCompared with BTBR ob/ob mice that received only vehicle, BTBR ob/ob mice treated with enarodustat displayed lower body weight, reduced blood glucose levels with improved insulin sensitivity, lower total cholesterol levels, higher adiponectin levels, and less adipose tissue, as well as a tendency for lower macrophage infiltration. Enarodustat-treated mice also exhibited reduced albuminuria and amelioration of glomerular epithelial and endothelial damage. Transcriptome analysis of isolated glomeruli revealed reduced expression of C-C motif chemokine ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) in enarodustat-treated mice compared with the vehicle-only group, accompanied by reduced glomerular macrophage infiltration. In vitro experiments demonstrated that both local HIF-1 activation and restoration of adiponectin by enarodustat contributed to CCL2/MCP-1 reduction in mesangial cells.ConclusionsThese results indicate that the PHD inhibitor enarodustat has potential renoprotective effects in addition to its potential to protect against metabolic disorders.
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Fabish, Rachael May. "Pākehā Working With Māori – Activists and Academics." Commoning Ethnography 2, no. 1 (2019): 132. http://dx.doi.org/10.26686/ce.v2i1.5446.
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How do we work together across difference? How can Pākehā work better with Māori? These were the questions at the heart of my PhD thesis, which examined how colonisation impacts the interpersonal relationships of Māori and Pākehā activists in Wellington, Aotearoa New Zealand. These questions also became central to the collaborative methodology employed as I grappled with moving from simply talking about power sharing, to meaningfully attempting to relinquish control within my research. This article discusses the collaborative methods I drew on, like anti-oppressive methodology, participatory action research, interactive interviewing and auto ethnography, in order to meet that challenge. This approach resulted in the formation of the ‘Black Rainbow’ collective, a small group of Māori and Pākehā activists (including myself) who undertook a collaborative research journey. This article shares part of that ‘Black Rainbow story’.
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Gray, Kishonna, and Reshawna Chapple. "#TenureTrackHustle : Examining Academic Poverty of First-Generation Women of Color From an Intersectional Standpoint." Journal of Working-Class Studies 2, no. 2 (2017): 5–15. http://dx.doi.org/10.13001/jwcs.v2i2.6079.
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Women of color in academia face challenging obstacles when it comes to surviving and thriving in the ivory tower. Enduring the grind of graduate school and immediately upon attaining a PhD, women of color are often burdened with heavy student loan debt, large teaching loads, unrealistic service expectations, experience microaggressions based on race, gender and class, isolation, alienation and other challenges which compound and negatively impact the path to tenure. Many of the challenges mentioned above often differ from those of their white and/or male counterparts in the academy. Throughout this article, we will examine the literature of Black women in academia, provide personal narratives situating these complexities, and root them all in the context of being Black and Woman in academia. The academy is a place we are rarely welcomed and constantly fighting to survive and thrive.
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Poviliūnas, Arūnas, Antanas Voznikaitis, Lina Mačiulė, Monika Juknienė, Elena Sinkevičiūtė, and Rima Žilinskaitė. "On the Attempt to Unlock the Black Boxes of Science (2)." Sociologija. Mintis ir veiksmas 43, no. 2 (2018): 7–42. http://dx.doi.org/10.15388/socmintvei.2018.2.1.
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This article further develops the ideas expressed in our previous publication – On the Attempt to Unlock the Black Boxes of Science (1) – and presents a sociological experiment that aims to break the conventional routine of the research activities of both sociology and life sciences. The article consists of two parts. The first part discusses the concept of “the new scientific spirit,” elaborated by French scientist and philosopher G. Bachelard, and introduces H. White’s theory of tropes, which provides a novel interpretative framework for “the new scientific spirit.” The second part of this article describes a didactic experiment comprised of two discussion groups with PhD students working in the field of life sciences. The first discussion group attempted to realize the principles of the sociology of the social, whereas the second one attempted to break the limits of the sociology of the social and to induce an epistemological rupture in order to realize the principles of the sociology of translation in the second discussion. This article also includes the authors’ reflections regarding the formation of their own sociological habitus.
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Schiemann, John Wilson. "Institutionalizing torture in Israel: The Firas Tbeish decision. A commentary by John W. Schiemann, PhD." Torture Journal 29, no. 2 (2019): 103–7. http://dx.doi.org/10.7146/torture.v29i2.116127.
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In her discussion of the court’s dismissal of the IP, she says there “is a legal system that discredits the IP’s potential while digging deeper into its own conception of torture.'' Shir has helped show that this is true more broadly of torture, beyond the IP. Indeed, I suspect the court may not view the IP as a “strange creature” causing “suspicion of the unfamiliar.” Instead, it may be by now a very familiar creature that threatens torture’s impunity in Israel, and what Shir shows is that the court has developed a systematic strategy to counter it. Torture is possible in Israel because the government and courts are complicit in deliberately creating a legal and institutional black hole where boundaries are ill-defined and obscure, and no light can shine.
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Perkins, Linda M. "Merze Tate and the Quest for Gender Equity at Howard University: 1942–1977." History of Education Quarterly 54, no. 4 (2014): 516–51. http://dx.doi.org/10.1111/hoeq.12081.
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This study discusses Merze Tate, a black woman faculty member at Howard University from 1942 to 1977, and her efforts throughout her tenure at the institution to obtain gender equity for women faculty. This study also discusses Tate's decades-long battle with Rayford Logan, chair of the history department of Howard. Both Harvard PhDs, their difficulties reflect both gender differences as well as professional jealously. Tate was the first black woman to earn a degree from Oxford University (International Relations, 1935) and the first black woman to earn a PhD from Harvard in the fields of government and international relations (1941). She joined the faculty at Howard University in 1942, as one of two women ever hired in the history department. She remained on the faculty until her retirement in 1977. Tate is significant not only for her academic accomplishments and her advocacy on behalf of women but also as one of the earliest tenured women faculty members at Howard. In addition, she was a part of a very small group of highly accomplished black women academics who devoted their lives to the education of black youth. In a 1946 study of black doctorate and professional degree holders, Harry Washington Greene noted that of the three hundred eighty-one recipients, only forty-five were women. Black women were overwhelmingly enrolled and graduated from teacher training colleges that were unaccredited and/or did not provide the curriculum to attend graduate school without taking an additional year of undergraduate studies. The time and cost factor were prohibitive and many black women attended summer schools for years to take courses to prepare them for a graduate degree program.
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Enis, Larry L. "Biblical Interpretation among African-American New Testament Scholars." Currents in Biblical Research 4, no. 1 (2005): 57–82. http://dx.doi.org/10.1177/1476993x05055640.
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Given the small, but growing, number of ethnic minorities in the field of biblical studies, the issue of African-American biblical hermeneutics has received only marginal attention in scholarly journals. In an effort to discern major themes and objectives among these interpreters, this article surveys published works by African Americans who have attained either a PhD or ThD in the New Testament. In this study, six areas of particular interest emerged: hermeneutics, the black presence in the New Testament, Paul, the Gospels, the epistle of James, and Revelation. Moreover, this investigation will demonstrate that the phenomenon of African-American New Testament hermeneutics is a methodologically diverse one.
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Silveira, Tanya Marie. "“But Where are you Really From?”: Approaching Music Therapy Research and Practice as an Australian of Indian Origin." Voices: A World Forum for Music Therapy 20, no. 3 (2020): 8. http://dx.doi.org/10.15845/voices.v20i3.3171.
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I have always been passionate about my work and research in stroke rehabilitation but never truly understood where this stemmed from. Drawing upon accessible music making, my PhD research developed and trialed a novel approach for post-stroke rehabilitation: an intervention created to simultaneously address arm/hand function and well-being outcomes. The focus of the research was to empower stroke survivors with limited to no movement in their arm/hand, as this subset of survivors are generally overlooked by the medical system (due to a projected poor prognosis of recovery). In 2020, during my engagement with the PhD research, the Black Lives Matter movement was reignited in response to the death of George Floyd. As a Woman of Colour, this movement deeply impacted me and led to reflection about my personal experiences of adversity. Through deep reflection, I started to understand the impact of my adverse experiences on my passion for advocacy in stroke rehabilitation. This paper explores the impact of my complex identity on my current approach to music therapy research and advocacy in stroke rehabilitation. Positioning myself as an Australian of Indian origin, I share personal reflections about my journey to research with the intent of highlighting the importance of visibility and change in music therapy research and practice.
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Seoane, Elena. "Telling the true Gibraltarian Story: an Interview with Gibraltarian writer M.G. Sanchez." Revista Alicantina de Estudios Ingleses, no. 29 (November 15, 2016): 251. http://dx.doi.org/10.14198/raei.2016.29.14.
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Born in Gibraltar in 1968, writer M. G. Sanchez moved to the UK to study English Literature at the age of twenty-seven, where he has lived ever since, with interludes in New Zealand (2004), India (2005-2008) and, more recently, Japan (2014-2016). He took BA, MA and PhD degrees at the University of Leeds, completing his studies in 2004 with a thesis exploring perceptions of ‘hispanicity’ in Elizabethan and Jacobean literature. His first publication was Rock Black: Ten Gibraltarian Stories, a collection of short narratives. Since then he has written three novels on Gibraltar – The Escape Artist, Solitude House and Jonathan Gallardo – as well as numerous stories and essays. His latest work, Past: A Memoir, was published in October 2016, and explores his own family history on the Rock.
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Arnold, Michael A., Tim D. Davis, and David W. Reed. "A Survey of Horticulture Graduate Programs and Faculty Salaries at North American Universities." HortScience 40, no. 4 (2005): 1137D—1137. http://dx.doi.org/10.21273/hortsci.40.4.1137d.
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Surveys were sent to 53 North American universities offering horticulture curricula to characterize the types of degrees offered, student demographics, participation in distance education, remuneration and assistance available for graduate students, and faculty rank and salary distributions. Twenty-five institutions responded. This represented 10 PhD, 14 MS, and 12 M. Agr. or MS non-thesis professional degree programs in horticulture and 13 PhD, 13 MS, 12 M. Agr. or M. non-thesis degree programs in plant sciences or a closely related area. On average, graduate students were predominantly Caucasian (70.7%), followed by Asian (16.1%), Black (3.2%), Hispanic (2.6%), and Native American (0.2%). Most were supported by research assistantships (56.3%), with the second largest group being self-supported (13.8%). Teaching assistantships were a small source of support (4.6%). Stipends (12-month equivalent) where variable among fellowships ($2000 to $30,000), teaching ($6600 to $25,000), research ($2000 to $25,239), extension ($12,000 to $17,000), or combination assistantships ($900 to $26,000). Most assistantships included a stipend plus in-state and out-of-state tuition waivers: about half included medical insurance. Mean full-time in-state tuition and fees was $6,535, while out-of-state was $13,876. Participation in distance courses was greatest for non-degree students (18.3%), and low for all others (9.2% to 6.4%). The average academic unit had 15.1 professors, 8.9 associate professors, 6.8 assistant professors, 0.3 senior lecturers, and 1.6 lecturers with mean reported average salaries of $85,142; $70,132; $58,918; $55,608; and $37,887, respectively.
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Asante, Molefi Kete. "The Relentless Pursuit of Discipline: An Africological March Toward Knowledge Liberation." Journal of Black Studies 49, no. 6 (2018): 531–41. http://dx.doi.org/10.1177/0021934718788646.
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In this article, Molefi Kete Asante, the founder of the first PhD program in African American Studies gives a personal account of the aims, objectives, and the challenges he and his principal colleagues faced in the creation of the program. Asante recounts the political and campus cultural climate that helped to facilitate the pursuit. However, the article centers on the pursuit of discipline despite the ever-present attempts to divert the theoretical and methodological direction of the department. Asante saw the creation of the doctorate as the end of the process that was begun by Nathan Hare at San Francisco State University when he created the Department of Black Studies. Temple’s graduation of more than 180 doctorates has established its presence in the Academy as a dominant player in discipline development at the graduate level for Africology.
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Dunston, Georgia M. "A passion for the science of the human genome." Molecular Biology of the Cell 23, no. 21 (2012): 4154–56. http://dx.doi.org/10.1091/mbc.e12-05-0342.
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The complete sequencing of the human genome introduced a new knowledge base for decoding information structured in DNA sequence variation. My research is predicated on the supposition that the genome is the most sophisticated knowledge system known, as evidenced by the exquisite information it encodes on biochemical pathways and molecular processes underlying the biology of health and disease. Also, as a living legacy of human origins, migrations, adaptations, and identity, the genome communicates through the complexity of sequence variation expressed in population diversity. As a biomedical research scientist and academician, a question I am often asked is: “How is it that a black woman like you went to the University of Michigan for a PhD in Human Genetics?” As the ASCB 2012 E. E. Just Lecturer, I am honored and privileged to respond to this question in this essay on the science of the human genome and my career perspectives.
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Giurfa, Martin, Anaclara Giurfa de Brito, Tiziana Giurfa de Brito, and Maria Gabriela de Brito Sanchez. "Charles Henry Turner and the cognitive behavior of bees." Apidologie 52, no. 3 (2021): 684–95. http://dx.doi.org/10.1007/s13592-021-00855-9.
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AbstractSocial movements in several countries are stimulating a reconsideration of academic structures and historic figures and promoting reparation and recognition of marginalized and forgotten black scientists. A paradigmatic case in that sense is Charles Henry Turner (1867–1923) who was the first African American to receive a graduate degree at the University of Cincinnati and one of the first in earning a PhD degree of the University of Chicago. He performed numerous experiments on sensory perception, orientation, and mating of solitary and social bees, most of which have been unjustly forgotten despite the fact that they anticipated fundamental concepts of animal cognition. We review these studies and highlight the importance of his ideas for modern views of animal cognition and the study of bee behavior. We conclude that besides his scientific contributions, Turner is an inspiration for scientists fighting against social adversity and prejudices.
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Tseng, Hung-Fu, Lei Qian, Jun Wu, et al. "19. Completion of Two-Dose Recombinant Zoster Vaccine Series in Adults 50 Years and Older." Open Forum Infectious Diseases 7, Supplement_1 (2020): S32—S33. http://dx.doi.org/10.1093/ofid/ofaa439.064.
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Abstract Background In 2017, the Advisory Committee on Immunization Practices preferentially recommended adjuvanted recombinant zoster vaccine (RZV) for adults ≥ 50 years as a two-dose series 2–6 months apart.1 We evaluated two-dose RZV completion and factors associated with completion. Methods The study included Kaiser Permanente Southern California members ≥ 50 years who received an RZV dose during April-November 2018 and had continuous membership 12 months before to 9 months after the 1st RZV dose (RZV1). Completion was defined as receipt of the 2nd dose ≥4 weeks to 9 months after RZV1 (allowing a 3-month grace period). Characteristics including age at RZV1, sex, race/ethnicity, Medicaid status, neighborhood level income and education, distance from home to medical office, comorbidities, history of herpes zoster, health care utilization before and after RZV1, receipt of influenza vaccine, vaccination month (supply shortage proxy), concomitant vaccine, department administering RZV1, medical center, and medically attended local or systemic reaction, pain, or gout after RZV1 were compared between completers and non-completers. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) for factors associated with completion were estimated by multivariable logistic regression. Results Among 31,120 RZV1 recipients, 67.2% completed the series within 9 months. In adjusted analyses, higher completion was associated with White compared with Black or Hispanic race/ethnicity, higher neighborhood income and education, no chronic pulmonary disease, diabetes, or dementia, more outpatient visits and fewer emergency department visits before or after RZV1, no hospitalizations after RZV1, receipt of influenza vaccine, receipt of RZV1 in June-November rather than April-May 2018, no concomitant vaccine with RZV1, and receipt of RZV1 in Family Practice rather than Internal Medicine. Systemic reactions or pain after RZV1 was not associated with completion. Table 2. RZV Series Completion by Selected Characteristics During Follow-up of Members Aged ≥50 Years Who Received at Least One Dose of RZV at Kaiser Permanente Southern California in April-November 2018 Table 2. RZV Series Completion by Selected Characteristics During Follow-up of Members Aged ≥ 50 Years Who Received at Least One Dose of RZV at KPSC in April-November 2018 Figure 1. Factors Associated with RZV Series Completion of Members Aged ≥ 50 Years Who Received at Least One Dose of RZV at KPSC in April-November 2018 Conclusion Completion of RZV series appears moderate in the early phase of implementation. Despite similar accessibility in a health care system, completion varied by race/ethnicity, socioeconomic status, health status, and care seeking behavior, suggesting areas to target for improvement. Disclosures Hung-Fu Tseng, MPH, PhD, GlaxoSmithKlein (Research Grant or Support) Lei Qian, PhD, GlaxoSmithKlein (Research Grant or Support) Jun Wu, MD, MS, GlaxoSmithKlein (Research Grant or Support) Yi Luo, PhD, GlaxoSmithKlein (Research Grant or Support) Lina S. Sy, MPH, GlaxoSmithKlein (Research Grant or Support) Katia Bruxvoort, PhD, MPH, GlaxoSmithKlein (Research Grant or Support) Bradley Ackerson, MD, GlasoSmithKlein (Research Grant or Support)
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Marinov, Georgi R. "Epidemics In The North Bulgarian Black Sea Region In XIX Century. 1. Contributions of assoc. Prof. Vladimir vassilev, MD, PHD, DMS For Their Study." Varna Medical Forum 9, no. 1 (2020): 7. http://dx.doi.org/10.14748/vmf.v9i1.7280.
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McGee, Ebony Omotola. "Interrogating Structural Racism in STEM Higher Education." Educational Researcher 49, no. 9 (2020): 633–44. http://dx.doi.org/10.3102/0013189x20972718.
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The racialized structure of STEM (science, technology, engineering, mathematics) higher education maintains gross inequities that are illustrative of structural racism, which both informs and is reinforced by discriminatory beliefs, policies, values, and distribution of resources. Thus, an examination into structural racism in STEM is needed to expose the marginalization of underrepresented groups in STEM and to improve understanding of the STEM policies, practices, and procedures that allow the foundation of racism to remain intact. I argue that, even at the top of the education hierarchy, Black STEM doctorate students and PhD degree holders consistently endure the racist residue of higher education institutions and STEM employers. Thus, this manuscript also discusses how universities institutionalize diversity mentoring programs designed mostly to fix (read “assimilate”) underrepresented students of color while ignoring or minimizing the role of the STEM departments in creating racially hostile work and educational spaces. I argue that, without a critical examination of the structural racism omnipresent in the STEM, progress in racially diversifying STEM will continue at a snail’s pace.
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Bierrenbach, Ana Luiza, Yoonyoung Choi, Paula M. Batista, et al. "1392. Evaluation of the Impact of a Single-dose Hepatitis A Vaccination in Brazil: a time-series analysis." Open Forum Infectious Diseases 7, Supplement_1 (2020): S705—S706. http://dx.doi.org/10.1093/ofid/ofaa439.1574.
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Abstract Background Brazil has transitioned from an intermediate to low hepatitis A virus endemic country, increasing the risk of severe Hepatitis A (HepA) disease. To control transmission, the HepA vaccine, MSD, was introduced in the National Childhood Immunization Program (NIP) in 2014 for children aged 12-24 months and extended to children under 5 years old in 2017. We evaluated the impact of the vaccination on the HepA incidence, associated healthcare resource utilization (HCRU), and costs. Methods We conducted an observational, retrospective study using Brazilian National Public Health Data (DATASUS). An interrupted time-series analysis was conducted for incidence rates (IR) of laboratory- or clinically-confirmed Hep A cases. Using a negative binomial regression model, we assessed changes in annual HepA IR between pre- (2010-2013) and post- (2015-2018) HepA vaccination periods and compared to predicted counterfactual rates without HepA vaccination. We compared HCRU and cost of Hep A-associated hospitalizations and outpatient procedures between pre- and post- HepA vaccination periods. Results Between 2010 and 2018, 32,295 Hep A cases occurred across all ages. Among the NIP target children aged 1-4 years, HepA vaccination was associated with an immediate HepA IR decrease (-52,5% of level change) and with a decrease in slope (-7.7% vs -67.6% per year for pre- and post-periods, respectively, Figure 1). We observed a similar trend in non- HepA vaccination target children aged 5-14 years with -57.1% of level change and slope change from -3.4% (pre- HepA vaccination) to -53.7% (post- HepA vaccination) per year (Table 1). Across all age groups, 14,468 Hep A cases were averted when compared to predicted counterfactual rates (Table 2). Overall, HepA-related hospitalization rate dropped 64% after NIP introduction of vaccination resulting in a cost reduction of 55%. The total number of outpatient procedures claimed among HepA-diagnosed patients reduced 18% with 42% cost reduction. Figure 1: time-series analyses of Hepatitis A incidence rate (IR) for NIP target population. Monthly number of hepatitis A cases observed over the study period (black line). Predicted trend based on the pre- HepA vaccination (red line) and post- HepA vaccination (blue line) monthly cases Table 1: Time-series analysis of the impact of the hepatitis A vaccination on the incidence rate level of change, according to age group Table 2: Number of observed, predicted counterfactual, and averted hepatitis A cases in the post- HepA vaccination period (2015-2018), according to age group. Conclusion In Brazil, the single-dose hepatitis A vaccine childhood program effectively reduced the Hepatitis A incidence, HCRU and associated-costs in vaccinated and in some non-vaccinated age groups. Disclosures Ana Luiza Bierrenbach, MD, MSc, PhD, MSD Brazil (Grant/Research Support, Scientific Research Study Investigator, Research Grant or Support) Yoonyoung Choi, PhD, MS, RPh, Merck (Employee) Paula M. Batista, BSc, MSD Brazil (Employee) Fernando Serra, MD, MSD Brazil (Employee) Cintia Parellada, MD, PhD, MSD Brazil (Employee) Guilherme Julian, BSc, MSc, IQVIA (Employee)MSD (Consultant, Research Grant or Support) Karina Nakajima, BSc, PhD, IQVIA (Employee)MSD (Consultant, Research Grant or Support) Thais Moreira, MD, MSc, MSD Brazil (Employee)
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Geibel, Brooke, James A. Dowell, Thomas C. Marbury, et al. "1318. Pharmacokinetics and Safety of Cefepime-Taniborbactam (formerly Cefepime/VNRX-5133) in Subjects with Renal Impairment." Open Forum Infectious Diseases 7, Supplement_1 (2020): S670. http://dx.doi.org/10.1093/ofid/ofaa439.1500.
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Abstract Background Taniborbactam is a novel, non-ß-lactam, ß-lactamase inhibitor with activity against serine (Class A, C, D) and metallo (Class B) ß-lactamases including epidemiologically important carbapenemases. Both cefepime and taniborbactam are predominantly renally excreted and are likely to require dose adjustment in patients with renal impairment and end-stage renal disease (ESRD). The current study was designed to evaluate the pharmacokinetics and safety in patients with renal impairment and ESRD. Methods This was a Phase 1, open-label study in subjects with normal renal function (eCLCR ≥ 90 mL/min) matched to subjects with mild, moderate, and severe renal impairment (eGFR 60-89, 30-59, and < 30 mL/min/1.73m2, respectively), and patients with ESRD on hemodialysis. Subjects received a single dose of cefepime 2 g and taniborbactam 500 mg; subjects with ESRD received a single dose before HD and after a 9 day washout period, following HD. PK parameters including AUC0-inf and total body clearance (CL) were evaluated. Safety assessments included adverse events (AEs), vital signs, clinical laboratory evaluations, electrocardiograms, and physical examinations. Results Thirty-three subjects were enrolled; 67% male, 58% white and 39% black/African Americans. Median age and BMI were 55.0 years and 29.5 kg/m2, respectively. For both cefepime and taniborbactam, exposures increased, and CL decreased with increasing renal impairment (see Table). The hemodialysis extraction ratio was 49.7% and 47.4% for taniborbactam and cefepime respectively. No safety signals were observed and there were no serious adverse events. Table Conclusion Cefepime and taniborbactam CL is similarly reduced with varying degrees of renal impairment. Dialysis removes a high fraction of both drugs. Dose adjustments recommended for cefepime are appropriate for taniborbactam. Disclosures Brooke Geibel, BS, Venatorx Pharmaceuticals (Employee, Shareholder) James A. Dowell, PhD, Venatorx Pharmaceuticals (Independent Contractor) Thomas C. Marbury, MD, Venatorx Pharmaceuticals (Independent Contractor) William Smith, MD, Venatorx Pharmaceuticals (Independent Contractor) Paul C. McGovern, MD, Venatorx Pharmaceuticals (Employee) Cynthia Richards, MD, Venatorx Pharmaceuticals (Independent Contractor) Tim Henkel, MD, PhD, Venatorx Pharmaceuticals (Employee, Shareholder)
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Andreatta, Kristen, Michelle L. D’Antoni, Silvia Chang, et al. "109. Preexisting Resistance and Week 48 Virologic Outcomes After Switching to B/F/TAF in African American Adults with HIV." Open Forum Infectious Diseases 7, Supplement_1 (2020): S183—S184. http://dx.doi.org/10.1093/ofid/ofaa439.419.
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Abstract Background The BRAAVE 2020 study is evaluating the safety and efficacy of switching to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) among virologically suppressed Black adults with HIV. At Week (W) 24, 0.6% (2/328) on B/F/TAF vs 1.8% (3/165) who stayed on their baseline 3 drug regimen (SBR) had HIV-1 RNA ≥ 50 c/mL demonstrating noninferiority of B/F/TAF. Here, resistance analyses and virologic outcomes at W48 are described. Methods Enrollment criteria permitted prior treatment failure, except on an INSTI-containing regimen, and allowed documented resistance to NNRTIs, PIs and/or NRTIs, except for K65R/E/N, ≥ 3 thymidine analog mutations (TAMs), or T69-insertions; primary INSTI resistance (-R) was excluded. Preexisting drug resistance was assessed with historical genotypes and proviral DNA genotyping. B/F/TAF outcomes were determined by last on-treatment HIV-1 RNA through W48. Results Altogether, 495 participants enrolled (B/F/TAF n=330, SBR n=165). Preexisting primary NRTI-R, NNRTI-R, and PI-R substitutions were observed in 14% (70/495), 21% (102/495), and 13% (62/495), respectively. M184V/I and TAMs were detected in 10% (51/495) and 7% (34/495), respectively. Primary INSTI-R was detected post-randomization in 2% (11/495); all continued on study and were included in efficacy analyses. At W24, 163 in the SBR group switched to B/F/TAF (SBR to B/F/TAF). W48 outcomes were determined for 489 participants who had ≥ 1 post-switch HIV-1 RNA measurement: 99% (324/327) in the B/F/TAF and 100% (162/162) in the SBR to B/F/TAF groups had HIV-1 RNA < 50 copies/mL at their last study visit, including 100% (68/68) with NRTI-R (50 of whom had archived M184V/I and post-switch data), and 100% (11/11) with INSTI-R (Table). No participant had treatment emergent resistance to study drugs. Table. BRAAVE 2020 Preexisting Resistance and Virologic Suppression at Week 48 (Last On-treatment Observation Carried Forward Analysis) Conclusion Preexisting resistance was common among virologically suppressed Black adults in BRAAVE 2020, notably M184V/I, TAMs, and NNRTI-R. High rates of virologic suppression were maintained through 48 weeks of B/F/TAF treatment and there were no failures with de novo resistance, indicating that B/F/TAF is an effective treatment option for virologically suppressed people with HIV with or without preexisting resistance to NNRTIs, PIs, or non-tenofovir NRTIs. Disclosures Kristen Andreatta, MSc, Gilead Sciences (Employee, Shareholder) Michelle L. D’Antoni, PhD, Gilead Sciences (Employee, Shareholder) Silvia Chang, Masters, Gilead Sciences (Employee, Shareholder) Aiyappa Parvangada, MS Computational Biology, Gilead Sciences (Employee) Christiana Blair, MS, Gilead Sciences (Employee, Shareholder) Sean E. Collins, MD, MS, Gilead Sciences (Employee) Kirsten L. White, PhD, Gilead Sciences, Inc. (Employee, Shareholder)
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Condorelli, F., G. Pescarmona, and Y. Ricci. "PHOTOGRAMMETRY AND MEDIEVAL ARCHITECTURE. USING BLACK AND WHITE ANALOGIC PHOTOGRAPHS FOR RECONSTRUCTING THE FOUNDATIONS OF THE LOST ROOD SCREEN AT SANTA CROCE, FLORENCE." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVI-M-1-2021 (August 28, 2021): 141–46. http://dx.doi.org/10.5194/isprs-archives-xlvi-m-1-2021-141-2021.
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Abstract. In this research paper photogrammetric techniques have been successfully applied to historic black and white analogic photographs to convey previously inaccessible architectural and archaeological information. The chosen case study for this paper is the Franciscan Basilica of Santa Croce in Florence, Italy. A photogrammetric algorithm has been implemented over a series of b/w negatives portraying the archaeological excavations carried out in the years 1967–1969, after the traumatic flood of the river Arno in 1966 that severely damaged the city centre of Florence and, particularly, the Santa Croce monumental site. The final aim of this operation is to provide solid evidence for the virtual reconstruction of the lost rood screen of the basilica of Santa Croce, the current subject of the PhD research of one of the Authors (Giovanni Pescarmona) at the University of Florence. The foundations that were uncovered during the archaeological excavation in the ‘60s are one of the most important hints towards a convincing retro-planning of the structure. Using advanced photogrammetric techniques, and combining them with LIDAR scanning, it is possible to uncover new datasets that were previously inaccessible for scholars, opening new paths of research. This interdisciplinary approach, combining traditional art-historical research methods and state-of-the-art computational tools, tries to bridge the gap between areas of research that still do not communicate enough with each other, defining new frameworks in the field of Digital Art History.
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Towner, William, Edwin DeJesus, Shannon Schrader, et al. "1027. Long-Term Efficacy, Safety, and Durability of Ibalizumab-Based Regimens in Subgroup of TMB-202 Participants." Open Forum Infectious Diseases 7, Supplement_1 (2020): S542—S543. http://dx.doi.org/10.1093/ofid/ofaa439.1213.
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Abstract Background Third line antiretroviral regimens have been associated with suboptimal virologic suppression, due to drug cross-resistance and regimen complexity. Yet, in treatment-experienced (TE) HIV patients, ART durability is essential for preventing further resistance and decreasing HIV-associated morbidity and mortality. Ibalizumab (IBA), the first long-acting, post-attachment inhibitor approved to treat multi-drug resistant (MDR) HIV, may support regimen durability given its directly observed administration. We analyzed the safety, efficacy, and durability of response in 12 patients who started IBA in a Phase 2b study. Methods In TMB-202, 113 patients with MDR HIV received either 2000 mg IBA every 4 weeks (n=54) or 800 mg IBA every 2 weeks (n=59) for 24 weeks with an optimized background regimen (OBR). Of 96 patients who completed TMB-202, 56 transferred into an investigator-sponsored investigational new drug protocol and 12 later moved onto an expanded access protocol, TMB-311, where efficacy and safety were monitored until IBA was commercially available (approval 2018). Results Baseline median viral load (VL) and CD4 count for the 12 patients were 4.4 log10 copies/mL (c/mL) and 135 cells/mL, respectively. The median duration of HIV infection was 22 years (range 18-25). At the completion of TMB-202 11/12 achieved virologic suppression (VL < 200 c/mL) and 8/12 had VL < 50 c/mL. All 12 patients were suppressed (VL < 50 c/mL) at their last TMB-311 visit. Patients gained an average of 99 CD4 cells/mL relative to baseline. There were no treatment-emergent adverse events (TEAE) or therapy discontinuations related to IBA during follow-up. Two patients died from unrelated causes. Overall, the 12 patients remained on IBA for an average of 8.9 years (range 8-9.5), during which 8/12 did not require addition of new ARVs to their OBR to maintain suppression. Figure 1: duration of ibalizumab-based regimen is displayed for the 12 patients. Grey bars represent patients with no addition of new ARVs to OBR. Black bars represent patients with an addition to OBR. Asterisks represent addition of ritonavir only. Conclusion Data from 12 patients who received IBA for an average of 9 years validate the long-term efficacy and safety of IBA in TE patients. Importantly, for most patients, the durability of virologic response was maintained with minimal adjustments to the OBR. Altogether, these data demonstrate the contribution of IBA towards durable viral suppression in TE HIV patients with limited therapeutic options. Disclosures William Towner, MD, Dynavax (Research Grant or Support)Gilead (Grant/Research Support)Merck (Research Grant or Support)Tai Med (Research Grant or Support)ViiV (Research Grant or Support) Edwin DeJesus, MD, Gilead Sciences (Advisor or Review Panel member) Colleen McGary, PhD, Theratechnologies (Employee) Mohammed Zogheib, PharmD, MPH, Theratechnologies (Employee) Steven Weinheimer, PhD, TaiMed Biologics USA (Employee) Pedro Mesquita, PhD, Theratechnologies, Inc. (Employee)
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Criner, Gerard J., Gerard J. Criner, Mi Young Ahn, et al. "561. Safety of Remdesivir vs Standard Care in Patients with Moderate Covid-19." Open Forum Infectious Diseases 7, Supplement_1 (2020): S345—S346. http://dx.doi.org/10.1093/ofid/ofaa439.755.
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Abstract Background Remdesivir (RDV) has been shown to shorten recovery time and was well tolerated in patients with severe COVID-19. Here we report safety of RDV in patients with moderate COVID-19. Methods We conducted an open-label, phase 3 trial (NCT04252664) in hospitalized patients with confirmed SARS-CoV-2 infection, evidence of pulmonary infiltrates, and oxygen saturation >94% on room air. Patients were randomly assigned to receive RDV (5 or 10 days) or standard of care (SOC). RDV was dosed intravenously at 200 mg on day 1, 100 mg daily thereafter. Adverse events (AEs) and laboratory abnormalities were evaluated through the day 11 data cut; safety data through day 28 will be presented at the meeting. Results 584 patients were randomized and treated (5d RDV: n=191; 10d RDV, n=193; SOC: n=200). Baseline characteristics were balanced among groups; median (range) age was 57y (12-95y), 39% were female and 19% Black, 39% had arterial hypertension, 15% hyperlipidemia, 11% asthma. Briefly, across both the 5d and 10d arms, RDV was well tolerated with a similar rate of Grade 3 or 4 AEs and fewer SAEs compared to SOC (Table). AEs more common with RDV vs SOC included nausea, headache, and hypokalemia. Overall, across the 3 arms, incidence of AEs leading to discontinuation and death were low and no clinically relevant changes in laboratory parameters were observed. In addition, median changes in renal and liver function tests from baseline were not statistically significant between the RDV 5d and RDV 10d groups compared to the SOC only group at d14 (Table 1). Table 1. Conclusion RDV given for 5d or 10d was well tolerated in patients with moderate COVID-19. No clinically significant safety signals were observed with RDV vs SOC. Disclosures Gerard J. Criner, MD, Gilead Sciences Inc. (Scientific Research Study Investigator)Regeneron (Scientific Research Study Investigator) Gerard J. Criner, MD, NO DISCLOSURE DATA Mi Young Ahn, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Gregory Huhn, MD, Gilead Sciences Inc. (Grant/Research Support, Scientific Research Study Investigator)Janssen (Grant/Research Support)Proteus (Grant/Research Support)US National Institutes of Health (Grant/Research Support)Viiv Healthcare (Grant/Research Support) Aruna Subramanian, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Carlos Lumbreras, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Stefan Schmiedel, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Robert H. Hyland, MD, Gilead Sciences Inc. (Employee, Shareholder) Vithika Suri, PhD, Gilead Sciences Inc. (Employee, Shareholder) Huyen Cao, MD, Gilead Sciences Inc. (Employee, Shareholder) Hongyuan Wang, PhD, Gilead Sciences Inc. (Employee, Shareholder) Devi SenGupta, MD, Gilead Sciences Inc. (Employee, Shareholder) Anand Chokkalingam, PhD, Gilead Sciences (Employee) Anu Osinusi, MD, Gilead Sciences (Employee) Diana M. Brainard, MD, Gilead Sciences (Employee) Yao-Shen Chen, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Yao-Shen Chen, MD, NO DISCLOSURE DATA Huldrych Günthard, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) D Jose Sanz-Moreno, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Judith A. Aberg, MD, Theratechnology (Consultant) Emanuele Nicastri, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Owen Tak-Yin Tsang, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Owen Tak-Yin Tsang, MD, NO DISCLOSURE DATA
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Thorpe, Jr, Roland J., Jamboor K. Vishwanatha, Eileen M. Harwood, et al. "The Impact of Grantsmanship Self-Efficacy on Early Stage Investigators of The National Research Mentoring Network Steps Toward Academic Research (NRMN STAR )." Ethnicity & Disease 30, no. 1 (2020): 75–82. http://dx.doi.org/10.18865/ed.30.1.75.
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The NRMN STAR program was created to address the persistent underrepresentation in grant submissions and receipt of National Institutes of Health (NIH) awards by racial/ethnic minority groups. In our current study, we assessed program impact on trainees’ self-efficacy related to grant writing. The program was conducted with two cohorts: one in June 2014 and one in June 2015. We used a 19-item grant writing self-efficacy scale drawn from the 88-item Clinical Research Assessment Inventory of three domains (conceptualizing, designing, and funding a study) to predict whether self-efficacy influences researchers’ grant submissions. Trainees were assessed prior to and following program completion with subsequent assessments at 6 and 12 months beyond participation. The majority of trainees were Black (62%), female (62%), and had obtained a PhD (90%). More than half (52%) were assistant professors and 57% had none or <1 year of research experience beyond postdoctoral training. However, 24% of trainees reported no postdoctoral research training. NRMN STAR trainees’ self-efficacy significantly improved on all three domains exhibiting a 2.0-point mean change score on two domains (conceptualizing and design) and 3.7 point mean change score on the domain, funding a study. Findings suggest that NRMN’s STAR provides impactful, confidence-building training for diverse, early stage investigators with little-to-no skills, experiences, or low self-efficacy in writing research grants. Ethn Dis. 2020;30(1):75-82; doi:10.18865/ed.30.1.75
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Castagna, Antonella, David Shu Cheong Hui, Kathleen M. Mullane, et al. "548. Baseline characteristics associated with clinical improvement and mortality in hospitalized patients with moderate COVID-19." Open Forum Infectious Diseases 7, Supplement_1 (2020): S340. http://dx.doi.org/10.1093/ofid/ofaa439.742.
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Abstract Background Remdesivir (RDV) has been shown to shorten recovery time and was well tolerated in patients with severe COVID-19. Here we report baseline characteristics associated with clinical improvement at day (d) 14. Methods We enrolled hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation &gt;94% on room air, and radiological evidence of pneumonia. Patients were randomized 1:1:1 to receive 5d or 10d of intravenous RDV once daily plus standard of care (SoC), or SoC only. For this analysis, patients were followed through discharge, d14, or death. Baseline demographic and disease characteristics associated with clinical improvement in oxygen support (≥2-point improvement on a 7-category ordinal scale ranging from discharge to death) were evaluated using multivariable logistic regression methods. Results 584 patients were randomized and treated (5/10d RDV, n=384; SoC: n=200). 159 (27%) were ≥65y, 227 (39%) female, 328 (61%) white, 102 (19%) Asian, and 99 (19%) Black. 252 participants (43%) were enrolled in Europe, 260 (45%) North America (NA), and 72 (12%) in Asia. Most patients (483 [83%]) were not on supplemental oxygen but required medical care at baseline. In a multivariable model, 5/10d RDV was significantly positively associated with clinical improvement (adjusted odds ratio [OR] 1.69, 95% CI: 1.08, 2.65; p=0.0226). Significant covariables positively associated with clinical improvement included age &lt; 65y (p&lt; 0.0001) and region of treatment (Europe and NA vs Asia, p&lt; 0.0001 each; Table); other examined factors were not significantly associated with clinical improvement, including gender, race, ethnicity, baseline oxygen support, duration of symptoms and hospitalization, obesity, and baseline transaminase levels. Table 1. Conclusion In moderate COVID-19 patients, after adjusting for treatment arm, age &lt; 65y and region (NA vs Asia; Europe vs Asia) were associated with higher rates of clinical improvement. These observations recapitulate younger age as positive prognostic factor, and highlight the differences in the impact of the pandemic globally. Disclosures Antonella Castagna, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) David Shu Cheong Hui, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Kathleen M. Mullane, DO, PharmD, Gilead Sciences Inc. (Grant/Research Support, Scientific Research Study Investigator) Mamta Jain, MD, Gilead Sciences Inc. (Scientific Research Study Investigator, Research Grant or Support)GlaxoSmithKline (Advisor or Review Panel member)Janssen (Research Grant or Support)Merck (Research Grant or Support) Massimo Galli, MD, Gilead Sciences Inc. (Grant/Research Support, Scientific Research Study Investigator, Advisor or Review Panel member, Other Financial or Material Support, Personal fees) Shan-Chwen Chang, MD, PhD, Gilead Sciences Inc. (Scientific Research Study Investigator) Robert H. Hyland, MD, Gilead Sciences Inc. (Employee, Shareholder) Devi SenGupta, MD, Gilead Sciences Inc. (Employee, Shareholder) Huyen Cao, MD, Gilead Sciences Inc. (Employee, Shareholder) Hailin Huang, PhD, Gilead Sciences Inc. (Employee, Shareholder) Anand Chokkalingam, PhD, Gilead Sciences (Employee) Anu Osinusi, MD, Gilead Sciences (Employee) Diana M. Brainard, MD, Gilead Sciences (Employee) Christoph Lübbert, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) David Chien Boon Lye, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) David Chien Boon Lye, MD, NO DISCLOSURE DATA Judith A. Aberg, MD, Theratechnology (Consultant) Enrique Navas Elorza, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Karen T. Tashima, MD, Bristol-Myers Squibb (Research Grant or Support)Gilead Sciences Inc. (Grant/Research Support, Scientific Research Study Investigator)GlaxoSmithKline (Research Grant or Support)Merck (Research Grant or Support)Tibotec (Research Grant or Support)Viiv Healthcare (Research Grant or Support) Mark McPhail, MD, Gilead Sciences Inc. (Scientific Research Study Investigator)
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Mathur, Poonam, Roman Kaplan, Amanda Theppote, Shyam Kottilil, and Eleanor Wilson. "1067. Interferon-free Hepatitis C Treatment Increases Surrogates of Cardiovascular Disease Risk in Black Veterans." Open Forum Infectious Diseases 7, Supplement_1 (2020): S562—S563. http://dx.doi.org/10.1093/ofid/ofaa439.1253.
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Abstract Background Sustained virologic response (SVR) after hepatitis C virus (HCV) treatment with either Interferon (IFN)-based or IFN-free regimens with direct-acting antivirals (DAAs) has been shown to reduce cardiovascular disease (CVD) events in majority white populations stratified by ASCVD score. However, the effect of IFN-free therapy on lipid profiles after SVR, as an indirect measure of CVD risk, is unknown in Black patients. Methods We evaluated HCV-infected Veterans from the Baltimore VA who were treated with DAAs between 2015-2019. We performed a retrospective analysis comparing lipid profile changes following SVR among those with early stage (F0-F2) fibrosis and advanced liver disease (ALD, F3-F4 fibrosis) using two-tailed paired t-tests. Independent t-tests were used to assess differences in lipid profiles based on fibrosis stage in patients with HIV and Type II Diabetes Mellitus (DM2). Results Of those treated for HCV (n=1,528), 96% (n=1,474) achieved SVR. Demographics are shown in Table 1. Most patients were Black males (75%) and a minority (2.7%) received statin therapy during treatment (Table 1). Of 1,094 patients for whom data was available, an increase in total cholesterol (TC) and LDL (p&lt; 0.01 for both) was seen an average of 17 months after SVR, regardless of fibrosis stage (Figure 1). A significant decrease in triglyceride levels (p=0.04) was also seen in the ALD group after SVR (Figure 1). Mean pre-treatment HCV RNA level was comparable between fibrosis groups (F0-F2: 6.35 logs, F3-F4: 6.37 logs, p=0.46). There were 101 and 436 patients with HIV and DM2, respectively, for whom pre-treatment liver fibrosis data was available. In both groups, there were significant increases in LDL (p=0.008 (HIV), p=0.003 (DM2)) among patients with ALD following SVR. Table 1. Baseline characteristics of treated HCV-infected persons who achieved SVR. Figure 1. Mean lipid profile parameters before and after HCV treatment for patients who achieved SVR. TC was measured a mean of 8.1 months (228 days, SD 333 days) before treatment and 17.4 months (488 days, SD 196 days) after SVR. LDL was measured a mean of 8 months (224 days, SD 284 days) before treatment and 17.5 months (492 days, SD 201 days) after SVR. *=differences in means using paired t-test were statistically significant with p&lt;0.05. HCV= Hepatitis C Virus, SVR= Sustained Virologic Response TC=Total Cholesterol, HDL= High Density Lipoprotein, LDL= Lipoprotein, TG= Triglycerides. Conclusion In a cohort of mostly Black HCV-infected Veterans, significant increases in TC, driven by increases in LDL, were seen after SVR regardless of fibrosis stage. In addition, patients with ALD and HIV or DM2, who have an inherently higher risk of CVD, had increased LDL levels, suggesting that these patients should be screened and treated for HCV prior to development of ALD. Correlates such as the ASCVD score should be considered in the timing of HCV treatment, in order to reduce the long-term risk of CVD. Disclosures Shyam Kottilil, MD PhD, Arbutus Pharmaceuticals (Grant/Research Support)Gilead Sciences (Grant/Research Support)Merck Inc (Grant/Research Support, Advisor or Review Panel member)
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Xing, Weirong, Sheila Pourteymoor, and Subburaman Mohan. "Ascorbic acid regulates osterix expression in osteoblasts by activation of prolyl hydroxylase and ubiquitination-mediated proteosomal degradation pathway." Physiological Genomics 43, no. 12 (2011): 749–57. http://dx.doi.org/10.1152/physiolgenomics.00229.2010.
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Mouse genetic studies reveal that ascorbic acid (AA) is essential for osteoblast (OB) differentiation and that osterix (Osx) was a key downstream target of AA action in OBs. To determine the molecular pathways for AA regulation of Osx expression, we evaluated if AA regulates Osx expression by regulating production and/or actions of local growth factors and extracellular matrix (ECM) proteins. Inhibition of actions of IGFs by inhibitory IGFBP-4, BMPs by noggin, and ECM-mediated integrin signaling by RGD did not block AA effects on Osx expression in OBs. Furthermore, blockade of components of MAPK signaling pathway had no effect on AA-induced Osx expression. Because AA is required for prolyl hydroxylase domain (PHD) activity and because PHD-induced prolyl-hydroxylation targets proteins to proteosomal degradation, we next tested if AA effect on Osx expression involves activation of PHD to hydroxylate and induce ubiquitin-proteosome-mediated degradation of transcriptional repressor(s) of Osx gene. Treatment of OBs with dimethyloxallyl glycine and ethyl 3, 4-dihydroxybenzoate, known inhibitors of PHD, completely blocked AA effect on Osx expression and OB differentiation. Knockdown of PHD2 expression by Lentivirus-mediated shRNA abolished AA-induced Osx induction and alkaline phosphatase activity. Furthermore, treatment of OBs with MG115, inhibitor of proteosomal degradation, completely blocked AA effects on Osx expression. Based on these data, we conclude that AA effect on Osx expression is mediated via a novel mechanism that involves PHD2 and proteosomal degradation of a yet to be identified transcriptional repressor that is independent of BMP, IGF-I, or integrin-mediated signaling in mouse OBs.
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Flanagan, Shawn, Christopher M. Rubino, and Taylor Sandison. "1174. Phase 2 STRIVE Clinical Trial of Rezafungin for Treatment of Candidemia and/or Invasive Candidiasis Demonstrates Consistent Trough Concentrations Across Diverse Patient Populations." Open Forum Infectious Diseases 7, Supplement_1 (2020): S612—S613. http://dx.doi.org/10.1093/ofid/ofaa439.1360.
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Abstract Background Rezafungin is a novel echinocandin antifungal in development for treatment as well as prevention (prophylaxis) of invasive fungal infections. STRIVE (NCT02734862) is a global, randomized, double-blind, placebo-controlled, Phase 2 trial evaluating safety and efficacy of IV rezafungin once weekly (QWk) for treatment of candidemia and/or invasive candidiasis compared with standard-of-care (IV caspofungin once daily with optional oral stepdown). Here we report pharmacokinetic (PK) data from the completed STRIVE trial analyzed by patient demographics at baseline. Methods Rezafungin Day 8 trough (Cmin) concentrations from patients treated with rezafungin were summarized categorically by race (black or white), sex (male or female), and geographic region (North America [NA], or Europe [EU]), or plotted versus continuous variables of age, body weight, body mass index (BMI), and body surface area (BSA). As the first dose of rezafungin was 400 mg for all rezafungin-treated patients, data from both dose groups (Group 1: 400 mg QWk; Group 2: 400 mg in Week 1 followed by 200 mg QWk) were combined in this analysis. Results Rezafungin mean Cmin (SD) values were 1.8 (0.7) and 2.3 (1.2) in black and white patients, 1.9 (1.0) and 2.6 (1.2) in males and females, and 1.9 (0.6) and 2.4 (1.3) in patients from NA and EU. There were small differences in point estimates between the groups, but there was a great deal of overlap and the differences are not expected to be clinically meaningful (Figure). Similarly, no trends in Cmin values were observed across a range of ages (20-80 years), weights (~40-155 kg), BMI (~15-65 kg/m2), and BSA (~1.4-2.4 m2). Figure Conclusion No meaningful differences in rezafungin Cmin values were observed in patients grouped by sex, race, or geographic region, or across a wide range of patient factors, including age and body weight and size. These findings indicate that a single rezafungin dose regimen can be expected to provide consistent PK across diverse patient populations. Disclosures Shawn Flanagan, PhD, Cidara Therapeutics, Inc. (Employee, Shareholder) Christopher M. Rubino, PharMD, Institute for Clinical Pharmacodynamics, Inc. (Employee)Spero Therapeutics (Grant/Research Support) Taylor Sandison, MD, MPH, Cidara Therapeutics, Inc. (Employee, Shareholder)
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Delgado, Maria, and David Fancy. "The Theatre of Bernard-Marie Koltès and the ‘Other Spaces’ of Translation." New Theatre Quarterly 17, no. 2 (2001): 141–60. http://dx.doi.org/10.1017/s0266464x0001455x.
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The work of the French playwright Bernard-Marie Koltès, although phenomenally successful in continental Europe, has been staged less frequently in Anglo-American theatres; and a major feature on his work in NTQ49 in February 1997, and the publication by Methuen later in the same year of a collection of three of his plays in English translation, brought him only belated recognition in print. In this paper, first presented at a recent gathering in France to mark the tenth anniversary of Koltès's death, Maria Delgado and David Fancy trace the trajectory of a number of his plays through the space of translation, including Roberto Zucco, Dans la solitude des champs de coton (In the Solitude of the Cottonfields), Quai Ouest (Quay West), and Combat de nègre et de chiens (Black Battles with Dogs). Koltès asserted in 1986 that ‘I have always somewhat disliked the theatre because theatre is the opposite of life; but I always come back to it and love it because it is the one place where you can say: this is not life’; and the poetic specificity of his work has posed significant challenges for an Anglo-American theatre culture imbued with actors' identification with character. Relying on testimonials from a variety of directors, translators, and actors, as well as evidence from productions in the UK, Ireland, and the US, the authors, who are both Koltès translators, trace the challenges that have faced English-speaking artists wishing to stage this demanding writer. Maria Delgado is Senior Lecturer in Drama at Queen Mary, University of London, and David Fancy is a freelance director based in Canada who is currently completing a PhD on Koltès's work.
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Bhuwal, Anish Kumari, Gulab Singh, Neeraj Kumar Aggarwal, Varsha Goyal, and Anita Yadav. "Isolation and Screening of Polyhydroxyalkanoates Producing Bacteria from Pulp, Paper, and Cardboard Industry Wastes." International Journal of Biomaterials 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/752821.
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Background. Polyhydroxyalkanoates (PHAs) are storage materials that accumulate by various bacteria as energy and carbon reserve materials. They are biodegradable, environmentally friendly, and also biocompatible bioplastics. Unlike petrochemical-based plastics that take several decades to fully degrade, PHAs can be completely degraded within a year by variety of microorganisms into CO2and water. In the present study, we aim to utilize pulp, paper, and cardboard industry sludge and waste water for the isolation and screening of polyhydroxyalkanoates (PHAs) accumulating bacteria and production of cost-effective PHB using cardboard industry waste water.Results. A total of 42 isolates showed black-blue coloration when stained with Sudan black B, a preliminary screening agent for lipophilic compounds, and a total of 15 isolates showed positive result with Nile blue A staining, a more specific dye for PHA granules. The isolates NAP11 and NAC1 showed maximum PHA production 79.27% and 77.63% with polymer concentration of 5.236 g/L and 4.042 g/L with cardboard industry waste water. Both of the selected isolates, NAP11 and NAC1, were classified up to genus level by studying their morphological and biochemical characteristics and were found to beEnterococcus sp., Brevundimonas sp.and, respectively.Conclusion. The isolatesEnterococcus sp. NAP11 andBrevundimonas sp. NAC1 can be considered as good candidates for industrial production of PHB from cardboard industry waste water. We are reporting for the first time the use of cardboard industry waste water as a cultivation medium for the PHB production.
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Christensen, Lois M., and Elizabeth K. Wilson. "Mamie P. Clark’s denied research “thou hast the power” E.B. Browning." Social Studies Research and Practice 13, no. 1 (2018): 105–12. http://dx.doi.org/10.1108/ssrp-01-2018-0006.
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Purpose Black women’s contributions to the struggle for educational equality and to the USA Civil Rights Movement have been deplorably under-examined and scarcely evident in educational literature. This historical, biographical account documents the life and challenges of one brilliant woman, Mamie Phipps Clark, PhD. The purpose of this paper is to consider how Mamie Phipps Clark encountered and connected with Thurgood Marshall to advance social justice and the historical outcomes in the Brown v. Board (1954) decision. More importantly, the ways in which young Black children perceived racial awareness and self-identity are examined, and the perniciously damaging effects frequently stated by children’s and their negatively held attitudes about skin color were revealed in her work (Clark and Clark, 1950). Design/methodology/approach This historiography examines Dr Mamie Phipps Clark’s scholarship. Central to Brown v. Board of Education was Dr Mamie Phipps Clark’s research agenda. She contributed to the USA’s history in the pursuit of justice and equity for children. To adequately prepare social studies and civics educators and students, the unknown has to be realized. To embrace Clark’s accomplishments within the educational literature is to forge a vast path of knowledge about children’s identity, racial awareness and psychological well-being. She worked determinedly for just ideals for generations of children and women preparing the way for just educational integration. Findings Nevertheless, until women, and essentially Black women’s scholarship and civic contributions are valued as imperative to foundational educational, civic, social studies, history canons the entirety of history remains veiled. When women’s scholarship by which our country achieved civic ideals is fully accepted, multicultural educators for social justice and action will claim Mamie P. Clark’s merited inclusion in the social studies and educational canon. Without the position, knowledge and expertise of Judge Thurgood Marshall, the momentous 1954 movement toward educational equity and civic righteousness would not have occurred. It took his skill, but mostly his powerful Black maleness to bring about just passage of Brown v. Board. Further, without the influential testimony of Dr Kenneth Clark at Brown v. Board the crucial argument of the “pernicious effects of segregation” would have not influenced the court in the same fashion as that of a Black woman. In fact, in one account (Pohlman, 2005), Mamie, P. Clark’s work is not mentioned when referencing a court cases’ detailed circumstances of the doll studies. Interestingly, Dr Henry Garrett, Mamie’s racist doctoral advisor is mentioned in the preliminary Virginia segregation court case as a prominent witness in this integration case without note of Dr Mamie Phipps Clark. Practical implications Howard University’s motto, Veritas et Utilitas, Truth and Service was key to Charles Houston, Thurgood Marshall, Mamie P. Clark and Kenneth Clark’s moral code. They lived the possibility to intensify equitable, equal, and accessible education by enacting legal civil rights agency and action. Nevertheless, pending any woman scholar, essentially women civic scholars, Black women’s foundational social studies scholarship and contributions are wholly vital to our educational history and canons. It is only when women’s precedents are included into the literature by which our country achieved civic justice, then social studies educators and educational researchers may begin to achieve gender inclusive practice while transforming social studies scholarship to better all students’ worlds. Social implications Dr Mamie Phipps Clark’s work endures, as does her history and advocacy for generations of children, especially children of color, as well as women scholars. Her equitable, historical place will be actualized as long as scholars continue to herald her scholarship and contributions to the civic and social studies canon of literature. Originality/value Dr Mamie Phipps Clark. Central to Brown v. Board of Education was Dr Mamie Phipps Clark’s scholarship. She contributed to the USA’s history in the pursuit of justice and equity for children. To adequately prepare social studies and civics educators and students, the unknown has to be realized. To embrace Clark’s accomplishments within the educational literature is to forge a vast path of knowledge about children’s identity, racial awareness and psychological well-being. She worked determinedly for ideals for generations of children and women preparing the way for educational integration.