Relevant bibliographies by topics / Bladder. Diseases

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Bladder. Diseases'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Bladder. Diseases"

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Nakamura, Haruka, Ryuji Sakakibara, Megumi Sugiyama, Fuyuki Tateno, Masashi Yano, Osamu Takahashi, Masahiko Kishi, et al. "Neurologic diseases that cause female urinary retention." Bladder 3, no. 1 (February 7, 2016): 20. http://dx.doi.org/10.14440/bladder.2016.70.

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Jung, Sungyong, and Jayoung Kim. "Biomarker discovery and beyond for diagnosis of bladder diseases." Bladder 7, no. 1 (March 24, 2020): 40. http://dx.doi.org/10.14440/bladder.2020.813.

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Birder, Lori A. "TRPs in bladder diseases." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1772, no. 8 (August 2007): 879–84. http://dx.doi.org/10.1016/j.bbadis.2007.04.003.

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Yu, Zhenyuan, Jinling Liao, Yang Chen, Chunlin Zou, Haiying Zhang, Jiwen Cheng, Deyun Liu, et al. "Single-Cell Transcriptomic Map of the Human and Mouse Bladders." Journal of the American Society of Nephrology 30, no. 11 (August 28, 2019): 2159–76. http://dx.doi.org/10.1681/asn.2019040335.

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BackgroundHaving a comprehensive map of the cellular anatomy of the normal human bladder is vital to understanding the cellular origins of benign bladder disease and bladder cancer.MethodsWe used single-cell RNA sequencing (scRNA-seq) of 12,423 cells from healthy human bladder tissue samples taken from patients with bladder cancer and 12,884 cells from mouse bladders to classify bladder cell types and their underlying functions.ResultsWe created a single-cell transcriptomic map of human and mouse bladders, including 16 clusters of human bladder cells and 15 clusters of mouse bladder cells. The homology and heterogeneity of human and mouse bladder cell types were compared and both conservative and heterogeneous aspects of human and mouse bladder evolution were identified. We also discovered two novel types of human bladder cells. One type is ADRA2A+ and HRH2+ interstitial cells which may be associated with nerve conduction and allergic reactions. The other type is TNNT1+ epithelial cells that may be involved with bladder emptying. We verify these TNNT1+ epithelial cells also occur in rat and mouse bladders.ConclusionsThis transcriptomic map provides a resource for studying bladder cell types, specific cell markers, signaling receptors, and genes that will help us to learn more about the relationship between bladder cell types and diseases.
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Yoon, Hana. "Chronic bladder diseases: overactive bladder and interstitial cystitis/bladder pain syndrome." Journal of the Korean Medical Association 64, no. 11 (November 10, 2021): 763–69. http://dx.doi.org/10.5124/jkma.2021.64.11.763.

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Background: Overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS) are debilitatingchronic bladder diseases that affect patients’ quality of life. Their etiologies and clinical phenotypes vary, and management strategies should be selected after excluding the possibilities of other pathological conditions with careful consideration of a multidisciplinary integrated approach to ensure optimal success.Current Concepts: OAB is a symptom complex characterized by urinary urgency and frequency and nocturia with or without urge incontinence, and its key symptom is urinary urgency. IC/BPS has symptoms similar to lower urinary tract symptoms (LUTS) associated with OAB but also has distinctly different symptoms, including the key symptom of an unpleasant sensation or pain perceived to be related to the urinary bladder associated with LUTS. Recent studies have revealed that these key symptoms of OAB or IC/BPS are also observed in some patients with other diseases. Patients showing no evidence of bacterial infection on urine culture and experiencing LUTS or pain for more than 6 weeks should be considered as having OAB or IC/BPS. Treatment strategies for OAB and IC/BPS focus on managing LUTS and bothersome pain. Noninvasive management should be considered initially, whereas surgical options should be considered only after conservative treatment failure.Discussion and Conclusion: OAB and IC/BPS symptoms overlap considerably in many patients. A more accurate differentiation of symptoms, including LUTS, would help achieve better treatment outcomes.
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Sarfraz, Muhammad, Shaista Qamar, Masood Ur Rehman, Muhammad Azam Tahir, Muhammad Ijaz, Anam Ahsan, Mulazim Hussain Asim, and Imran Nazir. "Nano-Formulation Based Intravesical Drug Delivery Systems: An Overview of Versatile Approaches to Improve Urinary Bladder Diseases." Pharmaceutics 14, no. 9 (September 8, 2022): 1909. http://dx.doi.org/10.3390/pharmaceutics14091909.

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Intravesical drug delivery is a direct drug delivery approach for the treatment of various bladder diseases. The human urinary bladder has distinctive anatomy, making it an effective barrier against any toxic agent seeking entry into the bloodstream. This screening function of the bladder derives from the structure of the urothelium, which acts as a semi-permeable barrier. However, various diseases related to the urinary bladder, such as hyperactive bladder syndrome, interstitial cystitis, cancer, urinary obstructions, or urinary tract infections, can alter the bladder's natural function. Consequently, the intravesical route of drug delivery can effectively treat such diseases as it offers site-specific drug action with minimum side effects. Intravesical drug delivery is the direct instillation of medicinal drugs into the urinary bladder via a urethral catheter. However, there are some limitations to this method of drug delivery, including the risk of washout of the therapeutic agents with frequent urination. Moreover, due to the limited permeability of the urinary bladder walls, the therapeutic agents are diluted before the process of permeation, and consequently, their efficiency is compromised. Therefore, various types of nanomaterial-based delivery systems are being employed in intravesical drug delivery to enhance the drug penetration and retention at the targeted site. This review article covers the various nanomaterials used for intravesical drug delivery and future aspects of these nanomaterials for intravesical drug delivery.
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Teeger, Susan, and Gregory T. Sica. "MR IMAGING OF BLADDER DISEASES." Magnetic Resonance Imaging Clinics of North America 4, no. 3 (August 1996): 565–81. http://dx.doi.org/10.1016/s1064-9689(21)00381-0.

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Coleman, Joshua F., and Donna E. Hansel. "Benign Diseases of the Bladder." Surgical Pathology Clinics 1, no. 1 (December 2008): 129–58. http://dx.doi.org/10.1016/j.path.2008.07.001.

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Abdalla Widaa, Dr Awad. "Superficial Urinary Bladder Cancer: Clinical Presentations and Management in Gezira Hospital for Renal Diseases and Surgery-Medani, Sudan." International Journal of Advanced Multidisciplinary Research and Studies 4, no. 3 (May 31, 2024): 900–907. http://dx.doi.org/10.62225/2583049x.2024.4.3.2869.

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Urinary bladder cancers are heterogeneous groups of tumors with different subtype and different behavior. Although there are improvement in the detection and management of urinary bladder cancer, the death to all remains high. GHRDS and NCI (Wad Medani-Sudan) records showed that there are increasing numbers of cases diagnosed as superficial bladder cancer in last years from their annual reports. This study aimed to determine the pattern of clinical presentation of superficial urinary bladder cancer, to detect any known risk factors, and to determine the pathological pattern in the studied patients so as to assist in optimizing the treatment of cancer bladders and provide practical guidance on the clinical management, and to evaluate the outcome by provision of trustful data and audit. With a focus on clinical presentation and recommendations. Study Design: Methods this is Descriptive, retrospective, prospective hospital-based study in which all patients presented to GHRDS and NCI with symptoms and signs of superficial bladder cancer proved by histopathology from June 2010 to September 2018. Data were retrieved by data sheets from all soft and hard data of patients from GHRDS and NCI and Data were fed to Statistical Package of Social Sciences (SPSS). Results: A total of 66 patients were confirmed to have superficial bladder cancer from June 2010 to September 2018. The disease is more common in male with ratio (3.1: 1). And peak incidence in the fifth and sixth decades of life. Most of the patients from central sudan (Gezira, Sinnar, Gadariff states) they represents 86,3%. Farmers were 36,4%. Painless gross Haematuria is the most common presenting symptom among the studied group, account for 87.8%%, followed by LUTS in 42.4%. all patients recorded with bladder cancer during the study period were 207 patients, only 66 patients (31.9%) were diagnosed as superficial urinary bladder cancer and was confirmed by the histopathology and there were 141 patients (68.1.%) diagnosed as invasive bladder cancer. transitional cell carcinoma was the most common type (TCC) in 97%. and only 3% as carcinoma in situ.
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Cho, Yongwon, Jong Mok Park, and Seunghyun Youn. "General Overview of Artificial Intelligence for Interstitial Cystitis in Urology." International Neurourology Journal 27, Suppl 2 (November 30, 2023): S64–72. http://dx.doi.org/10.5213/inj.2346294.147.

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Our understanding of interstitial cystitis/bladder pain syndrome (IC/BPS) has evolved over time. The diagnosis of IC/BPS is primarily based on symptoms such as urgency, frequency, and bladder or pelvic pain. While the exact causes of IC/BPS remain unclear, it is thought to involve several factors, including abnormalities in the bladder’s urothelium, mast cell degranulation within the bladder, inflammation of the bladder, and altered innervation of the bladder. Treatment options include patient education, dietary and lifestyle modifications, medications, intravesical therapy, and surgical interventions. This review article provides insights into IC/BPS, including aspects of treatment, prognosis prediction, and emerging therapeutic options. Additionally, it explores the application of deep learning for diagnosing major diseases associated with IC/BPS.
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Dissertations / Theses on the topic "Bladder. Diseases"

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Brand, Carolyn K. "Fibromyalgia and bladder irritability." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2005. https://ro.ecu.edu.au/theses/626.

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Urinary tract sensory symptoms provide an additional symptomatic burden for women with fibromyalgia. The urogenital symptoms of both fibromyalgia and interstitial cystitis have been described as non-infective sensory disorders, suggesting the existence of substantial clinical overlap between the two conditions. Research suggests that although interstitial cystitis has been treated as a specific bladder condition, it may be part of the disorder of central processing of sensory information as seen in fibromyalgia. The interstitial cystitis symptom index and problem index (ICSI/ICPI) have been used to measure lower urinary tract symptoms and to examine the impact of these symptoms in patients with interstitial cystitis. This current two phase study was designed to test the ICSI/ICPI for use within a population of women diagnosed with fibromyalgia known to be experiencing sensory bladder symptoms. Phase I involved focus group interviews and discussions with women who reported fibromyalgia and bladder irritability (N=lO). This phase was designed to identify whether the key indicators and the way in which women experienced bladder irritability were indexed by the ICSI/ICPI instrument. The second phase of the study tested the ICSI/ICPI within the fibromyalgia population for reliability and validity. Phase II data was derived via a self-administered questionnaire issued to women (N=90) who had been diagnosed with fibromyalgia by a rheumatologist and who were experiencing lower urinary tract sensory symptoms. Data analysis revealed two separate components in urinary symptom/problem combinations within the fibromyalgia population. These components were distinct from those described in the ICSI/ICPI. Subsequently, two separate subscales were developed to form the Fibromyalgia Bladder Index (FBI). The development and testing of the FBI within the fibromyalgia population has provided an accurate measure for assessing the symptoms and symptom impact of urinary symptoms for women with this condition. The FBI has been developed as an adjunct to clinical assessment and as an outcome measure for intervention therapies for patients with fibromyalgia and bladder irritability. Outcomes of this study form the basis to the following recommendations: further refinement of the FBI; utilisation of the index in fibromyalgia assessments; development of fibromyalgia educational, support and self help programs; pelvic fitness awareness and intervention studies.
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Waldeck, Kristian. "Targets for pharmacological intervention in the bladder and urethra." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945055.html.

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Rehman, Haroon, Sukesh Manthri, Sonia Oad, and Kanishka Chakraborty. "Not Your Regular Run-of-the-Mill Bladder Cancer." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/77.

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Bladder cancer is the one of the most common malignancies of the genitourinary system and the overwhelming majority of those cases, approximately 90% in the United States(1), are of the urothelial/transitional cell histologic type. Small cell histologic type of bladder cancer is extremely rare with a mean frequency of 0.7% (1), and due to its rarity, there have not been any large phase III clinical trials in order to establish a definitive treatment regimen. We report here one such case of this rare type of bladder cancer and our approach towards treatment. A 69-year-old man had an incidental finding of microscopic hematuria during routine annual testing performed by his primary care physician. He was referred to a urologist for further evaluation, and in the interim, he began to experience symptoms of nocturia, dysuria and gross hematuria. Cystoscopy revealed a 5 cm sessile mass within the bladder and transurethral resection of the tumor was performed. Histopathological analysis of the tumor revealed muscle invasive poorly differentiated urothelial carcinoma with neuroendocrine features suggestive of small cell carcinoma. Follow-up systemic imaging only revealed multiple lesions in the liver, with the largest solitary liver lesion measuring 4.4 x 3.4 cm and no discrete lung lesions. Patient was started on palliative systemic chemotherapy with carboplatin and etoposide and follow-up imaging demonstrated excellent response after four cycles of treatment; however, follow-up imaging after the completion of 6 cycles of treatment demonstrated disease progression. Patient was referred for consideration of enrollment into any clinical trials; however, unfortunately no trials were found to be available. Patient was subsequently offered systemic treatment with single-agent immunotherapy with pembrolizumab. Due to development of left sided hydronephrosis, nephrostomy tube placement was performed and patient was also started on palliative radiation. Primary small cell carcinoma (SCC) of the bladder is an exceedingly rare malignancy and therefore, data is not readily available in order to guide treatment decisions. The most commonly administered regimen consists of etoposide with a platinum agent, and this regimen is extrapolated from the treatment of SCC of the lung. However, as for patients like ours, who had progression of disease in a short interval and are deemed primary treatment (platinum) refractory, the prognosis certainly becomes far more grim and the treatment choices even more limited. In sharing our treatment approach, we hope to be able to provide insight towards potential future treatment choices for this most-challenging diagnosis, primary small cell carcinoma of the bladder. (1) Blomjous CE, et. al. Small cell carcinoma of the urinary bladder. A clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer. 1989 Sep 15; 64(6):1347-57.
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Altman, Daniel. "Evaluation and treatment of pelvic organ prolapse : clinical, radiological and histopathological aspects /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-628-6237-5/.

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Imamov, Otabek. "Role of estrogen receptor beta in mouse prostate and bladder with references to human diseases /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-324-5/.

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Gashugi, Phophina Muhimpundu. "Prevalence and impact of urinary incontinence on quality of life among adult Kigali women." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

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Urinary incontinence has already been identified worldwide for years as a health problem affecting essentially women, which can interfere with their overall quality of life. However in Rwanda, this problem has yet not been addressed adequately either because of lack of expertise, or because of cultural traditions associated with taboos among women. Social conditions of women facing this problem hinder them from seeking possibly adequate medical assistance. It is important that this problem be addressed because it may lead to disability, social seclusion, psychological stress and economic burdens. This study was a pioneer one, intended to diagnose the extent of the problem through determining the prevalence of urinary incontinence as well as its impact on the quality of life among women. The study will hopefully be followed by the promotion of physiotherapy to tackle the problem and therefore reduce the number of people suffering from urinary incontinence.
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Diaz, salmeron Raúl. "Directed-mobility and enhanced-adhesion nano-platelets for local drug delivery : towards a new treatment of bladder diseases." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS458.

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Titre : Nano-plaquettes à mobilité dirigée et adhésion amplifiée pour l’administration locale: vers un nouveau traitement des maladies vésicalesAbstract : L’administration locale des médicaments, définie comme une voie d’administration où la substance active est directement administrée sur ou proche de la cible ou tissus souhaités, permet d’apporter des grandes quantités des médicaments avec moins d’effets secondaires, et permet une simplification du système nanoparticulaire du fait de la non-extravasation des médicaments. Dans ce contexte, le projet de recherche de cette thèse s’est focalisé sur la voie intra-vésicale comme voie d’administration locale car il existe un besoin clinique de la part des patients, n’étant pas encore résolu. Malgré les hypothétiques avantages fournis par l’administration locale des médicaments, la voie intra-vésicale présente certaines limitations qui diminuent l’efficacité des traitements et l’observance des patients. La plupart des médicaments pour le traitement des maladies vésicales, notamment pour le cancer de la vessie et les cystites interstitielles, sont sous forme de solutions ou suspensions administrées de manière intra-vésicale via un cathéter qui passe à travers l’urètre. Dès leur arrivée à la vessie, les substances actives sont fortement diluées par les urines et éliminées rapidement lors de la miction. Cela conduit à une diminution des concentrations des substances actives au plus proche de l’épithélium, nécessitant plusieurs instillations intra-vésicales, réalisées par des praticiens hospitaliers, pour atteindre des concentrations thérapeutiques. Il y a donc un réel besoin de développer des nouvelles formulations permettant de contrecarrer les phénomènes décrits au préalable.L’objectif de cette thèse de doctorat est de créer un nouveau système nanoparticulaire de morphologie non-sphérique qui serait susceptible d’avoir un mouvement diffèrent et dirigé ainsi qu’une adhésion amplifiée. En conséquence, nous attendons de ces systèmes qu’ils apportent des concentrations en substances actives plus importantes que les systèmes nanoparticulaires sphériques et formulations galéniques traditionnelles.Aux cours de nos travaux expérimentaux, nous avons réussi à développer un système nanoparticulaire de morphologie hexagonale et aplatie. Ces nanoparticules, appellées nano-plaquettes, sont conçues à partir de l’auto-assemblage des molécules d’α-CD et des chaines alkyles greffées sur les squelettes de polysaccharides tels que l’acide hyaluronique, la chondroïtine sulfate ou l’héparine. Ces systèmes présentent l’originalité de ne pas avoir de substance active encapsulé parce que les molécules de polymère elles mêmes agissent à la fois en tant que substance active et de véhicule. Ces nano-plaquettes ont montré un mouvement en milieu isotrope et statique très diffèrent des nano-sphères utilisées comme contrôle. En effet, la majorité d’entre elles diffuse de manière plus importante et dirigée, avec des trajectoires rectilignes. Grâce à leur mouvement et aux propriétés inhérentes liées à leur forme, ces systèmes se sont montrés particulièrement intéressants vis-à-vis des interactions avec des cellules. Ils adhèrent mieux et plus longtemps à la muqueuse vésicale, elles sont mieux internalisées par des cellules et sont éliminées plus lentement une fois adhérées à la surface de l’urothélium.Un modelé in vivo de Syndrome de la Vessie Douloureuse / Cystite Interstitielle développé chez le rat nous a permis de montrer l’efficacité thérapeutique des nano-plaquettes, notamment celle constituées d’acide hyaluronique. En effet, elles présentent une meilleure bioaccumulation dans la vessie et une meilleure activité anti-inflammatoire et de régénération de la muqueuse urothéliale.Ces systèmes nanoparticulaires, conçues lors de nos travaux de thèse, constituent une approche innovante, rationnelle et efficace pouvant ouvrir de nouvelles voies de recherche pour le traitement des maladies vésicales
Title: Directed-mobility and enhanced-adhesion nano-platelets for local drug delivery: towards a new treatment of bladder diseases.Abstract: Local drug delivery, defined as the administration route where the drug is delivered directly or very close to its target or tissue, allows to bring large amounts of drugs with reduced side effects, in comparison with systemic administration. In this context, our research project has been focused on the intravesical drug delivery as local administration route, because there is a real need to develop new pharmaceutical formulations to thwart several limitations. Despite the advantages provided by the local drug delivery, intravesical drug delivery exhibited some issues which are decreasing the therapeutic efficacy and the patient compliance to the treatment. Most of therapies for the treatment of bladder diseases are simple drug solutions or suspensions administered intravesically by using a catheter through the urethra in order to reach easily the bladder and, consequently, the urothelium. Since the drug is administered into the bladder, drug dilution is occurring because the continuous production of urine. Furthermore, active substances are being eliminated during washout when bladder urine voiding is happening. These two processes lead to the decrease of local drug concentration close to the urothelium. Patients need repeated catheterization, performed by health care practitioners, to reach therapeutic dose of the drug. Therefor, there is a need of new drug formulations to avoid these main limitations.The main goal of this PhD thesis was to create and design a new nanoparticulate system with non-spherical shape susceptible to move in a different manner compared to spherical nanoparticles. These systems may exhibit an amplified mucoadhesion allowing to bring more important amounts of drug than classical and nanoparticle administration.During this thesis, we developed a new nanoparticulate system presenting non-spherical, hexagonal and flattened shape. The driven force for the design of these nanoparticles was the self-assembling of α-cyclodextrin molecules with alkyl chains grafted on the polymer skeleton. Polymers used belong to a polysaccharide family called glycosaminoglycans including hyaluronic acid, chondroitin sulfate or heparin. This original and innovative nanoparticulate system does not encapsulate an active drug. Our polysaccharide will act, at the same time, as the active drug and the carrier. These nanoparticles, called now nano-platelets have shown different movement behavior than the spherical ones. Indeed, they diffuse more rapidly in a straight-line way. Thanks to their oriented and directed motion and to their intrinsic properties, due to the shape, these systems have shown a better mucoadhesion on the bladder tissue, a better uptake in different cell lines and they were far less rapidly eliminated from the urothelium mucosa.An in vivo model of Bladder Painful Syndrome / Interstitial Cystitis in rats demonstrated the therapeutic efficacy of nano-platelets, especially for hyaluronic acid nanoparticles. Indeed, they demonstrated a better bioaccumulation into the bladder and a better therapeutic efficacy as anti-inflammatory and urothelium regenerating agents.These nanoparticulate systems, designed during this work, represent a new innovative, rational and effectiveness approach allowing to open new research pathways for the treatment of bladder diseases
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Fava, Rafaela Marono [UNESP]. "Influência da fixação e de métodos de secagem na detecção de alterações proliferativas ultraestruturais induzidas pelo Diuron no urotélio vesical de ratos wistar." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/110666.

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Diuron is a substituted urea herbicide, carcinogenic to the rat urinary bladder at high dietary levels (2500 ppm). Different scanning electron microscopy (SEM) processing methods resulted in differing observations of early urothelial changes induced by exposure to this herbicide. This study evaluated the influence of SEM processing methods on the detection of urothelial alterations induced by diuron. Male Wistar rats were divided into 3 groups: control (basal diet), 7.1% Sodium Saccharin (NaS) (positive control) and 2500 ppm diuron, and fed for 7 days or 15 weeks. Urinary bladders were fixed with Bouin’s or glutaraldehyde fixative and processed by critical point drying (CPD) or by hexamethyldisilazane (HMDS) for comparison of the cytotoxic and proliferative changes induced by diuron in the urothelium. Histological and cell proliferation evaluations were also performed. After seven days, no differences in the incidence of histological urothelial lesions or labeling indices were detected among the groups; however, the incidence of urothelial lesions after 15 weeks was significantly increased in the animals fed diuron or NaS. After seven days or 15 weeks, the severity of urothelial alterations was significantly higher in animals fed with diuron. Both fixative and drying methods allowed for the identification of prenecrotic swollen superficial cells in the urothelium after seven days exposure to 2500 ppm diuron. Our results confirmed that the presence of prenecrotic swollen cells in the urothelium is an early key event due to diuron cytotoxicity and is not an artifact related to the processing methods used
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Fava, Rafaela Marono. "Influência da fixação e de métodos de secagem na detecção de alterações proliferativas ultraestruturais induzidas pelo Diuron no urotélio vesical de ratos wistar /." Botucatu, 2014. http://hdl.handle.net/11449/110666.

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Orientador: Maria Luiza Cotrim Sartor de Oliveira
Coorientador: Mirielen Garcia Nascimento e Pontes
Banca: Maria Lucia Zaidan Dagli
Banca: Daniela Carvalho dos Santos
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Abstract: Diuron is a substituted urea herbicide, carcinogenic to the rat urinary bladder at high dietary levels (2500 ppm). Different scanning electron microscopy (SEM) processing methods resulted in differing observations of early urothelial changes induced by exposure to this herbicide. This study evaluated the influence of SEM processing methods on the detection of urothelial alterations induced by diuron. Male Wistar rats were divided into 3 groups: control (basal diet), 7.1% Sodium Saccharin (NaS) (positive control) and 2500 ppm diuron, and fed for 7 days or 15 weeks. Urinary bladders were fixed with Bouin's or glutaraldehyde fixative and processed by critical point drying (CPD) or by hexamethyldisilazane (HMDS) for comparison of the cytotoxic and proliferative changes induced by diuron in the urothelium. Histological and cell proliferation evaluations were also performed. After seven days, no differences in the incidence of histological urothelial lesions or labeling indices were detected among the groups; however, the incidence of urothelial lesions after 15 weeks was significantly increased in the animals fed diuron or NaS. After seven days or 15 weeks, the severity of urothelial alterations was significantly higher in animals fed with diuron. Both fixative and drying methods allowed for the identification of prenecrotic swollen superficial cells in the urothelium after seven days exposure to 2500 ppm diuron. Our results confirmed that the presence of prenecrotic swollen cells in the urothelium is an early key event due to diuron cytotoxicity and is not an artifact related to the processing methods used
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ALBUQUERQUE, NETO Moacir Cavalcante de. "Alterações da função vesical devido ao envelhecimento em mulheres avaliadas através do estudo urodinâmico." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17455.

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Objetivos: O declínio da função vesical com a idade pode levar a comprometimento da qualidade de vida além de sérios problemas de saúde aos idosos. Assim, avaliaremos as alterações da função vesical com o envelhecimento em mulheres através do estudo urodinâmico e tentaremos desenvolver fórmulas que possam estimar os valores esperados dos parâmetros urodinâmicos avaliados de acordo com a idade. Materiais e métodos: Foi realizada uma análise retrospectiva dos estudos urodinâmicos realizados no Serviço de Urologia do Departamento de Cirurgia do Hospital das Clínicas da UFPE, cadastrados no prontuário eletrônico www.infomed.net.br entre maio de 2011 e novembro de 2015, a fim de obter e calcular os parâmetros necessários para avaliar a função vesical em diferentes faixas etárias (18-30, 31-40, 41-50, 51-60, 61-70, 71-80 e maior que 80 anos). Além disso, excluímos pacientes com qualquer fator conhecido que tenha o potencial de afetar a função vesical que não a idade. Resultados: De um total de 3103 exames analisados, foram selecionadas 719 pacientes do sexo feminino para serem incluídas no estudo. A média de idade das pacientes foi de 49,3 anos e em todos os parâmetros avaliados (fluxo máximo, volume urinado, complacência vesical, capacidade cistométrica máxima, pressão detrusora no fluxo máximo, resíduo pós-miccional, índice de contratilidade vesical e índice de eficiência vesical) obtivemos correlação estatisticamente significante entre o declínio da função vesical e a idade. Ainda, conseguimos expressar por equações matemáticas a relação de causa-efeito por regressão linear. Conclusão: O presente estudo observou que há uma diminuição da função vesical tanto de armazenamento (diminuição da capacidade cistométrica máxima e complacência vesical) quanto de esvaziamento (diminuição do fluxo máximo, da pressão detrusora no fluxo máximo, do volume urinado, do índice de contratilidade vesical e do índice de eficiência vesical, assim como o aumento do resíduo pós-miccional) com o envelhecimento. Paralelamente, estamos propondo fórmulas que podem estimar os valores esperados dos parâmetros urodinâmicos avaliados de acordo com a idade, na população estudada.
Purposes: The bladder function declines with age and can lead to impaired quality of life and serious health problems in the elderly. The aim of the study is to evaluate changes in bladder function with aging in women by urodynamic study and try to develop equations that can estimate the expected values of the urodynamic parameters evaluated according to the age. Methods: A retrospective analysis of urodynamic studies in the Urology Service of the Department of Surgery - Hospital das Clínicas, Federal University of Pernambuco, recorded in the electronic medical database www.infomed.net.br among May 2011 and November 2015 was performed in order to obtain and calculate the parameters necessary to evaluate bladder function in different age groups (18-30, 31-40, 41-50, 51-60, 61-70, 71-80 and above 80 years). Patients with any factor that had the potential to affect bladder function were excluded. Results: 3103 urodynamics studies were analyzed and 719 female patients were selected. The average age of patients was 49.3 years and in all evaluated parameters (maximum flow, volume of urination, bladder compliance, maximum cystometric capacity, detrusor pressure at maximum flow, post-void residual urine volume, bladder contractility index and bladder voiding efficiency) statistically significant correlation between the decline of bladder function and age were obtained. Also we presented mathematical equations with cause-effect relationship by linear regression. Conclusion: The present study showed that there is a decrease in the bladder storage function (reduction in maximum cystometric capacity and bladder compliance) and in the bladder emptying function (reduction of the maximum flow, detrusor pressure at maximum flow, volume of the urination, contractility index urinary bladder and bladder voiding efficiency , as well increased post-void residual urine volume) with aging. Analyzing data let us to propose equations that can estimate the expected values of the urodynamic parameters evaluated according to the age in the studied population.
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Books on the topic "Bladder. Diseases"

1

M, Fitzpatrick John, and Krane Robert J. 1943-, eds. The bladder. Edinburgh: Churchill Livingstone, 1995.

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1950-, Young Robert H., ed. Pathology of the urinary bladder. New York: Churchill Livingstone, 1989.

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1930-, Mackay Bruce, ed. Atlas of bladder pathology. New York: Igaku-Shoin, 1991.

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1958-, Atala Anthony, and Slade Debra, eds. Bladder disease: Research concepts and clinical applications. New York: Kluwer Academic/Plenum Publishers, 2004.

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Antonio, Lopez-Beltran, and Bostwick David G, eds. Bladder pathology. Hoboken, N.J: Wiley-Blackwell, 2012.

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Wein, Alan J. Overactive bladder in clinical practice. London: Springer, 2007.

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M, Freeman Robert, and Malvern John, eds. The Unstable bladder. London: Wright, 1989.

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Epstein, Jonathan I. Bladder biopsy interpretation. Philadelphia, PA: Lippincott Williams & Wilkins, 2005.

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George, N. J. R. 1946- and Gosling J. A. 1939-, eds. Sensory disorders of the bladder and urethra. Berlin: Springer-Verlag, 1986.

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D, Oliver R. T., and Coptcoat Malcolm J, eds. Bladder cancer. Plainview, N.Y: Cold Spring Harbor Laboratory Press, 1998.

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Book chapters on the topic "Bladder. Diseases"

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Tailor, Visha K., and G. Alessandro Digesu. "Overactive Bladder." In Postmenopausal Diseases and Disorders, 133–44. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13936-0_8.

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Newton, Alisa L. "Swim Bladder Disorders." In Fish Diseases and Medicine, 230–43. Boca Raton, Florida : CRC Press, [2019]: CRC Press, 2019. http://dx.doi.org/10.1201/9780429195259-13.

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Fry, John. "Gall Bladder, Liver and Pancreas." In Common Diseases, 231–33. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-4924-9_27.

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Almeida Pinto, Rui. "Bladder Pain Syndrome/Interstitial Cystitis." In Postmenopausal Diseases and Disorders, 121–32. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13936-0_7.

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Paulie, S., and P. Perlmann. "Immunological Features of Human Bladder Cancer." In Immunology of Malignant Diseases, 151–66. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3219-7_9.

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Maccagnano, Carmen, Rodolfo Hurle, and Elena Vittoria Longhi. "Interstitial Cystitis/Bladder Pain Syndrome." In Managing Psychosexual Consequences in Chronic Diseases, 499–513. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-31307-3_40.

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Kabaalioğlu, Adnan, and Gregory T. MacLennan. "Cystic Diseases of the Kidney." In Genitourinary Radiology: Kidney, Bladder and Urethra, 95–119. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-84800-245-6_3.

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Cruz, Francisco, Carlos Silva, and Paulo Dinis. "TRPV1 agonist therapies in bladder diseases." In Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation, 211–25. Basel: Birkhäuser Basel, 2005. http://dx.doi.org/10.1007/3-7643-7379-2_11.

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John, H., N. Abo Youssef, and A. Ploumidis. "Robotic Surgery Applications for Benign Bladder Diseases." In Robotic Urologic Surgery, 735–44. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-00363-9_66.

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Ogawa, Teruyuki, and Naoki Yoshimura. "Pathologies of the Basal Ganglia, such as Parkinson's and Huntington's Diseases." In Essentials of the Adult Neurogenic Bladder, 71–77. First edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780429320675-11.

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Conference papers on the topic "Bladder. Diseases"

1

Zagainova, Elena, Natalia D. Gladkova, O. Strelzova, A. Sumin, Grigory V. Gelikonov, Felix I. Feldchtein, and Rashid R. Iksanov. "Clinical study of bladder diseases using optical coherence tomography." In EOS/SPIE European Biomedical Optics Week, edited by Stefan Andersson-Engels and James G. Fujimoto. SPIE, 2000. http://dx.doi.org/10.1117/12.407610.

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Rafailov, Ilya, Scott Palmer, Karina Litvinova, Victor Dremin, Andrey Dunaev, and Ghulam Nabi. "A novel excitation-emission wavelength model to facilitate the diagnosis of urinary bladder diseases." In SPIE BiOS, edited by Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Alfred Nuttal, et al. SPIE, 2015. http://dx.doi.org/10.1117/12.2077554.

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Vesnovsky, Oleg, L. D. Timmie Topoleski, Laurence W. Grossman, Jon P. Casamento, and Liang Zhu. "Evaluation of Temperature Transients at Various Body Temperature Measuring Sites Using a Fast Response Thermistor Bead Sensor." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14065.

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Body temperature monitoring of humans has been an important tool for helping clinicians diagnose infections, detect fever, monitor thermoregulation functions during surgical procedures, and assess post-surgery recovery.1–3 Fever itself is typically not considered a disease. It is a response of the body to a disease, which is often inflammatory in nature. Elevation of the set point at the body temperature control center, the brain hypothalamus, is caused by circulating pyrogens produced by the immune system responding to diseases. Since the brain hypothalamus is not easily accessed by thermometers, other body locations have been identified as alternative measuring sites. Those sites include the pulmonary artery, rectum, bladder, distal esophagus and nasopharynx, sublingual surface of the tongue, under the armpit, tympanic membrane, and forehead.
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Braga, Vinícius Lopes, Wladimir Bocca Vieira de Rezende Pinto, Bruno de Mattos Lombardi Badia, José Marcos Vieira de Albuquerque Filho, Igor Braga Farias, Paulo Victor Sgobbi de Souza, and Acary Souza Bulle Oliveira. "Spastic paraplegia type 73: expanding phenotype of the first two Brazilian families." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.552.

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Context: Hereditary spastic paraplegias (HSPs) represent an expanding group of neurodegenerative diseases characterized mainly by progressive spastic paraparesis of the lower limbs. More than 80 different genetic loci have been associated with HSPs. In 2015, heterozygous pathogenic variants in the CPT1C gene were first associated with SPG73, not yet described in Brazilian patients. Objective: We present clinical, neuroimaging and genetic features of three Brazilian patients with SPG73. Cases reports: We report one male and two female patients, age range 36 to 78 years old. Case 1 presented with a 4-year-history of spasticity, predominantly crural tetraplegia, bladder incontinence, dysphagia and dysphonia. Family history disclosed a sister with epilepsy. Whole-exome sequencing (WES) disclosed a heterozygosis variant c.863G>A (p.Arg288His) in exon 9 of the CPT1C. Cases 2 and 3 are first degree relatives (mother and son). Both presented with long-standing slowly progressive spastic paraplegia. Case 3 presented bladder incontinence, constipation, dysphagia and dysphonia at late stages. Cases 2 and 3 WES disclosed the heterozygosis variant c.196T>G (p.Phe66Val) in exon 4 of the CPT1C. Discussion: Previous literature described six patients from an Italian family with pure HSPs phenotype and the pathogenic variant c.109C>G (p.Arg3. 7Cys) in CPT1C gene. Another group described three patients associated with pure HSPs phenotype and the pathogenic variant (c.226C>T) in the CPT1C gene. All previous reported cases had benign clinical course and bulbar involvement was not described before. One of our cases presented with a de novo variant and rapidly progressive motor and bulbar compromise. Conclusion: our cases expand the current knowledge about SPG73, including a rapidly progressive phenotype with bulbar involvement and cognitive compromise at late stages of disease course.
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Whitney, Jon, William Carswell, Matthew DeWitt, John Robertson, Chris Rylander, and Marissa Nichole Rylander. "Spatial Measurement of Viability in Tissue Phantoms and Ex Vivo Bladder Tissue in Response to Photothermal Therapy and Single Walled Carbon Nanohorns." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80903.

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Cancer is one of the most deadly diseases and leading cause of death. Laser based photothermal therapy can provide a minimally invasive alternative to surgical resection. The selectivity and effectiveness of laser therapy can be greatly enhanced when photoabsorbing nanoparticles such as nanoshells, single walled carbon nanotubes, multi-walled carbon nanotubes, or single wall carbon nanohorns (SWNHs) are introduced into the tissue[1]. Quantitative methods for measuring tumor response to nanoparticle enhanced laser therapies are critical for determining appropriate laser parameters and nanoparticle properties needed to achieve maximum therapeutic benefit. We have previously reported a new method for measuring two dimensional (2D) spatial viability distributions in cell monolayers in response to laser irradiation and nanoparticles. This method has been refined to allow determination of cell viability in three dimensions (3D) within a more physiologically representative tumor volume. This refined method was used to determine the viability of breast cancer cells suspended within sodium alginate tissue phantoms following treatment with SWNHs and external laser irradiation. The tumor treatment volume was accurately quantified in response to varying laser treatment parameters and nanoparticle concentrations. Spatial cellular viability was also measured in ex vivo pig bladders in response to SWNHs and laser irradiation to provide a more anatomically relevant environment. These new measurement methods enable quantification of spatial viability and therapeutic effectiveness, using 3D tumor environments which are more representative than cell monolayers.
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SHEN, M. C., S. H. CHEN, and K. S. LIN. "TWO CASES OF NEONATAL PURPURA FULMINANS HOMOZYGOUS FOR PROTEIN C DEFICIENCY IN A CHINESE FAMILY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644308.

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Protein C (PC) deficiency associated with hereditary venous thromboembolic disease was first reported in 1981 and is inherited as an autosomal dominant disorder. The prevalence of heterozygous PC deficiency is estimated to be 1 to 4% in venous thrombotic diseases. The homozygous PC deficiency is even rare, and has been reported in only about 10 families througout the world. It usually presents in newborn infants as purpura fulminans or severe thrombotic disease. We herein report two newborn brothers in a Chinese family, who manifested with purpura fulminans soon after birth and died at age of 21 days and 27 days respectively. Vitamin K was administered to the second baby after birth. Both parents are not consanguineous and there were no family histories of thromboembolism on paternal and maternal sides. Blood sample was not available for specific studies in the first baby. PC antigen level by electroimmunoassay was <6% in the second baby and 49% and 60% respectively in their mother and father. Antithrombin III activity by amidolytic method was 49% in the second baby, and 90% and 97% respectively in their mother and father. Vitamin K-dependent coagulation factors and factor V were within the expected range for a newborn. Factor VIII and fibrinogen level were notably decreased. Autopsy findings of the two newborns demonstrated the similar pictures characterized by fibrin thrombi in blood vessels causing extensive hemorrhagic infarts of skin, lung, liver, kidneys, testis, urinary bladder, esophagus and brain. Our Data indicate that neonatal purpura fulminans can be familial and caused by severe homozygous PC deficiency.
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Mekki, Yosra M., Mohamed M. Mekki, Mohamed Hamammi, and Susu Zughaier. "Virtual Reality Module Depicting Catheter-Associated Urinary Tract Infection as Educational Tool to Reduce Antibiotic Resistant Hospital-Acquired Bacterial Infections." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0250.

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Introduction: Virtual reality (VR) and augmented reality (AR) are used as simulation models in student-patient interactive medical education and shown to enhance learning outcomes. The rise in global burden of infectious diseases and antibiotic resistance world-wide prompt immediate action to combat this emerging threat. Catheter associated urinary infections (CAUTI) are the leading cause of hospital-acquired infections. The aim of this research is to develop a virtual reality (VR) based educational tool depicting the process of CAUTI caused by antibiotic resistant bacteria. The VR-CAUTI module is designed to provide insights to health care providers and community which help in reducing the burden of antibiotic resistant infections. Material and methods: The VRCAUTI module is designed using tools including Blender, Cinema4D and Unity to create a scientifically accurate first-person interactive movie. The users are launched inside a human bladder that needs to be drained. They can witness the insertion of a medical catheter into the bladder to drain the urine. Bacteria adhere to the catheter to establish colonization and infection. An interaction between antibiotic molecules and bacteria in the biofilm is observed later. After designing the 3D models, a highlight of the interaction between models, taken from the storyboard, is used to determine the necessary animation. Moreover, dialogue that facilitates the understanding of infections and antibiotic resistance is recorded. This is followed by the assembly of the module on Unity, and enrichments such as lights and orientation. Results and conclusion: This VRCAUTI module is the proof-of-concept for designing detailed VR based scientifically very accurate medical simulation that could be used in medical education to maximize learning outcomes. VR based modules that have the potential to transform and revolutionize learning experience and render medical education compatible with the IoT in the current 4th industrial revolution.
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Pinto, Wladimir Bocca Vieira de Rezende, Bruno de Mattos Lombardi Badia, Igor Braga Farias, José Marcos Vieira de Albuquerque Filho, Roberta Ismael Lacerda Machado, Paulo Victor Sgobbi de Souza, and Acary Souza Bulle Oliveira. "Expanding the neurological and imaging phenotype of women with adult-onset X- linked Adrenoleukodystrophy." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.019.

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Background: X-linked Adrenoleukodystrophy (X-ALD) represents a key inherited metabolic disorder in neurological practice, representing an important differential diagnosis in different neurological contexts. Symptomatic female patients have been scarcely studied in large cohorts. Objectives: Evaluation of clinical, laboratory and genetic findings from a Brazilian cohort of women with X-ALD. Methods, design and setting: We performed a retrospective observational study of clinical, biochemical, genetic, neuroimaging and neurophysiological aspects of 10 Brazilian female patients with X-linked Adrenoleukodystrophy under clinical follow-up at the Neurometabolic Unit, Division of Neuromuscular Diseases, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. Results: Mean age at diagnosis was 46.2 years and at symptom-onset was 39 years. Female patients presented with spastic paraparesis and neurogenic bladder (60%), cognitive decline (50%), demyelinating sensorimotor polyneuropathy (40%), cerebellar ataxia (30%), epilepsy (20%), apraxia and psychotic symptoms (10%). The most common misdiagnosis were Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia. The main neuroimaging findings were corticospinal tract hyperintensity and cervical and thoracic spinal cord atrophy (60%), unspecific white matter changes (40%) and typical parieto-occipital leukodystrophy. All patients had abnormal profiles of plasma very-long chain fatty acids, all with elevated C26 levels and 80% with elevated C24 levels, but all with abnormally raised C26:C22 and C26:C24 ratio. The most common pathogenic variant observed was c.311G>A (p.Arg104His) (60%). Conclusions: Female patients with ABCD1 pathogenic variants must be carefully evaluated for neuropsychiatric disturbances and followed-up until elderly due to the common occurrence of variable motor, autonomic and sensory compromise.
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Aditya Chowdary, Tripuraneni Venkata, and Ramalingam Trivikraman. "IDDF2018-ABS-0045 Incidental gall bladder cancer in laparoscopic cholecystectomy." In International Digestive Disease Forum (IDDF) 2018, Hong Kong, 9–10 June 2018. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-iddfabstracts.81.

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Yeh, Hsin-Chih, Nirmish Singla, Elizabeth Hernandez, Vandana Panwar, Vitaly Margulis, Payal Kapur, Shahrokh F. Shariat, Wen-Jeng Wu, and Jer-Tsong Hsieh. "Abstract B21: PTRF promotes cell survival and predicts disease progression in upper tract urothelial carcinoma." In Abstracts: AACR Special Conference on Bladder Cancer: Transforming the Field; May 18-21, 2019; Denver, CO. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.bladder19-b21.

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Reports on the topic "Bladder. Diseases"

1

Zhu, Zhihong, Yue Zhuo, Haitao Jin, Boyu Wu, and Zhijie Li. Chinese Medicine Therapies for Neurogenic Bladder after Spinal Cord Injury: A protocol for systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0084.

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Neurogenic bladder (NB), a refractory disease, is characterized by voiding dysfunction of bladder and/or urethra, and spinal cord injury (SCI) is a common cause. Chinese medicine therapies have been applied extensively in the treatment of neurogenic bladder, especially in China, and the results are promising but varying. Thus, the aim of this work is to assess the efficacy and safety of various Chinese medicine therapies for neurogenic bladder after spinal cord injury. Condition being studied: Chinese medicine therapies; Neurogenic bladder after spinal cord injury. Main outcome(s): The primary outcome of our NMA will be measured by overall response rate and urodynamic tests, which includes postvoiding residual urine volume, maximum urinary flow rate, and maximal detrusor pressure.
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Leonardo, Kevin, Doddy Hami Seno, Hendy Mirza, and Andika Afriansyah. Biofeedback Pelvic Floor Muscle Training and Pelvic Electrical Stimulation in Women with Overactive Bladder : A Systematic Review and Meta-analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0024.

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Review question / Objective: Population : Overactive Bladder, Women; Intervention : Biofeedback assisted PFMT and/or pelvic Electrical Stimulation with non-implanted electrodes (on the skin surface around perianal, intra vaginal or rectal); Comparison : PFMT only / Bladder Training / Life style modification-recommendation; Outcome : Changes in Quality of life, Incontinence Episodes, Number of participant cured/improved. Condition being studied: Overactive Bladder syndrome which has been defined as urinary urgency. It is not life threatening disease, therefore, often ignored by patients, but the effect in daily life can be very bothersome.
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