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1

Kečan, Ana. "(CYBER) PUNK'S NOT DEAD – RICHARD MORGAN'S ALTERED CARBON." Knowledge International Journal 34, no. 6 (2019): 1603–7. http://dx.doi.org/10.35120/kij34061603k.

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The term cyberpunk refers to an offspring or subgenre of science fiction which rose to popularity in the 1980s. It was first coined by Bruce Bethke in his story of the same name, published in 1983. Even though there are critics today who claim that cyberpunk is long dead, numerous examples from the 21st century show that it is still very well and alive, and this revival is particularly aided by television, as cyberpunk has a massive visual potential. Hence, the 21st century saw the sequel to the cult Blade Runner (originally released in 1982), titled Blade Runner 2049 (released in 2017), anoth
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2

Lynn, J. "John Richard Stares Blake." BMJ 349, sep09 26 (2014): g5525. http://dx.doi.org/10.1136/bmj.g5525.

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3

GOCKO, x. "Un agent conversationnel empathique ?" EXERCER 34, no. 195 (2023): 291. http://dx.doi.org/10.56746/exercer.2023.195.291.

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« Apparemment, nous sommes privés d’un talent spécifiquement humain – on appelle ça l’empathie, si je ne m’abuse. » (L’androïde Garland à Rick Deckard) Philip K. Dick, Les androïdes rêvent-ils de moutons électriques ? Blade Runner Un jour avec un patient en fin de vie à domicile, nous nous sommes mis à parler de Blade Runner, le livre de Philipp K. Dick était sur sa table de nuit en édition originale… Au coeur du livre et du film culte est un questionnement sur l’humanité. Dans ce monde postapocalyptique (1992 dans le livre, 2019 dans le film), Deckard pourchasse des androïdes censés être dépo
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Bierma, Troy. "Permaculture as Richard Bauckham’s Living with Other Creatures:." De Ethica 8, no. 4 (2025): 57–74. https://doi.org/10.3384/de-ethica.2001-8819.258456.

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To have moral standing to blame is to have a right to blame. But what kind of right is it, and what follows from having or lacking standing? I will argue that moral standing to blame should be understood as a power according to Wesley Hohfeld’s classification of rights (1913). It is a normative power to call for an uptake of blame from someone who is liable to blame, i.e., someone who is blameworthy. The function of standing norms, I will argue, is to protect the freedom and interests of persons who are or could be blamed. I make three further claims in distinction to recent scholarship on sta
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5

Keenan, Siobhan. "Re-reading Shakespeare’s Richard III: Tragic Hero and Villain?" Linguaculture 2017, no. 1 (2017): 23–34. http://dx.doi.org/10.1515/lincu-2017-0003.

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Abstract The discovery of the body of the historical Richard III under a Leicester car park in 2012 sparked fresh interest in one of England’s most controversial kings. Accused of murdering his nephews—the Princes in the Tower—Richard’s reign was cut short when he was defeated by Henry Tudor, Earl of Richmond (later Henry VII), at the Battle of Bosworth (1485). Richard was subsequently demonised in Tudor historiography, perhaps most famously by Sir Thomas More in his “History of King Richard the thirde” (printed 1557). It is to More that we owe the popular image of Richard III as a “croke back
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Lapping, Mark B. "Under the Blade: The Conversion of Agricultural Landscapes. Edited by Richard H. Olson and Thomas A. Lyson. 1998. Westview Press, 5500 Central Ave., Boulder, CO 80301-2877. xxii + 459 pp. $25.00, ISBN 0-8133-3597-3, paper." American Journal of Alternative Agriculture 14, no. 1 (1999): 47. http://dx.doi.org/10.1017/s0889189300008031.

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COOPER, TIM. "Richard Baxter and the Savoy Conference (1661)." Journal of Ecclesiastical History 68, no. 2 (2017): 326–39. http://dx.doi.org/10.1017/s0022046916001482.

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The 1661 Savoy Conference has generally been seen as a failure for which Richard Baxter is principally to blame. While it is true that he must share in the responsibility, it should be shared more widely. This article argues that the failure at the Savoy was the end result of tactical errors made a year earlier by the wider Presbyterian leadership who then left Baxter to shoulder the blame alone; and that the restored bishops never had any intention of offering any meaningful concessions at the Savoy.
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8

Paley, Morton D. "William Blake, Richard Phillips and the Monthly Magazine." Studies in Romanticism 51, no. 1 (2012): 41–57. http://dx.doi.org/10.1353/srm.2012.0040.

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9

Double, Richard. "Blaming the victim and blaming the culprit." Think 4, no. 10 (2005): 21–24. http://dx.doi.org/10.1017/s1477175600001147.

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Psychologists and common sense recognize blaming the victim as a cognitive error (fallacy) that many of us use to support the just-world hypothesis — the view that life is basically fair. In this article Richard Double compares a related phenomenon, blaming the culprit. When we commit the fallacy of blaming the culprit we mistakenly conclude that judging a culprit to deserve blame for an action exonerates everyone else from blame for that action. Double provides several examples of the fallacy.
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10

Dunphy, Jim. "Book Review: Enough Blame to Go Around, by Richard Steier." Labor Studies Journal 39, no. 4 (2014): 320–21. http://dx.doi.org/10.1177/0160449x14567295c.

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11

Straus, Lawrence Guy. "The Dawn of Human Culture. Richard G. Klein , Blake Edgar." Journal of Anthropological Research 59, no. 3 (2003): 338–40. http://dx.doi.org/10.1086/jar.59.3.3631483.

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12

Walker, Nigel. "Even More Varieties of Retribution." Philosophy 74, no. 4 (1999): 595–605. http://dx.doi.org/10.1017/s0031819199000704.

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Professor Cottingham's article ‘Varieties of Retribution’ in the Philosophical Quarterly, 1979, 29, 238ff. is discussed, and new varieties of retributivism are outlined and criticised, particularly those proposed by Richard Burgh, Michael Moore and Robert Nozick. The ‘Kantian gap’ between moral censure and the obligation to punish is emphasised. Distinctions are drawn between theories which make punishment a duty and those which make it a right, and also between those based on the notion of a rule and those based on the expression of blame.
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13

García Montes de Oca, Alberto. "La batalla de Santa Cruz de Tenerife, de 30 de abril de 1657." Revista de Historia Canaria, no. 205 (2023): 105–24. http://dx.doi.org/10.25145/j.histcan.2023.205.05.

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This is the greatest battle of the History of Tenerife, and happened during the Anglo-Spanish War of 1655-1660, although Historiography relieves it to a residual place among the Canarian historical events. This, put in Santa Cruz waters the only complete Indian Fleet lost entirely in a harbour, and in a single event. In this participated the New Spain Fleet, of Diego de Egues, joined to the defense of Santa Cruz, commanded by Alonso Dávila y Guzmán, against the English Army of Robert Blake and his second, Richard Stayner.
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14

West, Aaron J. "Eubie Blake: Rags, Rhythm, and Race by Richard Carlin and Ken Bloom." Fontes Artis Musicae 68, no. 2 (2021): 183–85. http://dx.doi.org/10.1353/fam.2021.0016.

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15

Wolf-Meyer, Matthew. "The Nature of Sleep." Comparative Studies in Society and History 53, no. 4 (2011): 945–70. http://dx.doi.org/10.1017/s0010417511000466.

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In April of 2004, only a few months into my fieldwork, I was struck by the level and variety of doubt expressed by the physicians at the Midwest Sleep Disorder Center (MSDC). The MSDC is a group of physicians recognized in the field as experts in many areas of sleep medicine, especially parasomnias—such as sleepwalking, sleep-related eating, and REM behavior disorder. Dr. Richards, the clinic's senior researcher and a neurologist by training, began the weekly departmental rounds. Generally, these consisted of case studies presented by the assembled clinicians and fellows, but at times rounds w
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16

Atkins, Gareth. "Religion in the British Navy, 1815–1879: Piety and Professionalism, by Richard Blake." English Historical Review 130, no. 544 (2015): 765–67. http://dx.doi.org/10.1093/ehr/cev112.

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17

Chu, Aaron, and Nancy Mata. "Richard Blake, FNSS: The Medal of Honor Recipient of the National Sculpture Society." Sculpture Review 72, no. 2 (2023): 13–20. http://dx.doi.org/10.1177/07475284231182575.

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18

Maho, Tea, Joseph J. Bevitt, and Robert R. Reisz. "New specimens of the early Permian apex predator Varanops brevirostris at Richards Spur, Oklahoma, with histological information about its growth pattern." PeerJ 11 (February 15, 2023): e14898. http://dx.doi.org/10.7717/peerj.14898.

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An articulated pelvic region and additional isolated material of Varanops brevirostris, which are indistinguishable from those of the generotype from the Cacops bonebed, demonstrate the presence of this large varanopid at the Richards Spur locality. The articulated specimen includes lumbar, sacral, and anterior caudal vertebrae, partial pelvis, femur, and proximal part of tibia, confirming the autapomorphies previously suggested for this species. These include the presence of distinct blade-like shapes of the neural spines in the sacral region, the presence of deeply excavated pubis, and the p
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19

Vallilères, Marc. "Richard GEREN et Blake McCULLOGH, L'héritage de Caïn : histoire de la Compagnie minière I.O.C." Recherches sociographiques 33, no. 1 (1992): 140. http://dx.doi.org/10.7202/056677ar.

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20

Wolpoff, Milford H. "The Dawn of Human Culture. By Richard G. Klein and Blake Edgar." American Journal of Archaeology 107, no. 4 (2003): 660–61. http://dx.doi.org/10.1086/ajs40024329.

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21

Plumb, Donovan. ""Thinking Again: Education after Postmodernism" (Nigel Blake, Paul Smeyers, Richard Smith, and Paul Standish)." Paideusis 12, no. 2 (2020): 57–59. http://dx.doi.org/10.7202/1073090ar.

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22

Goldstein, Amanda Jo. "Reluctant Ecology in Blake and Arendt: A Response to Robert Mitchell and Richard Sha." Wordsworth Circle 46, no. 3 (2015): 143–55. http://dx.doi.org/10.1086/twc24888030.

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23

SIRENKO, BORIS I., and HIROSHI SAITO. "New species of chitons of the superfamily Cryptoplacoidea (Mollusca: Polyplacophora) from Vietnamese waters." Zootaxa 4299, no. 4 (2017): 451. http://dx.doi.org/10.11646/zootaxa.4299.4.1.

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Twelve species of the polyplacophoran genera Notoplax, Leptoplax, Acanthochitona and Cryptoplax (Chitonida: Acanthochitonina: Cryptoplacoidea) were found in Vietnamese waters for the first time. Five of them, namely Notoplax conica, Leptoplax doederleini, Leptoplax richardi n. comb., Acanthochitona achates and A. biformis, are new to Vietnamese fauna. The remaining seven species are new to science, namely: Notoplax odysseyi n. sp., Leptoplax nhatrangi n. sp., L. tongkingi n. sp., Acanthochitona condaoi n. sp., A. lanae n. sp., A. nigra n. sp. and A.ostreaphila n. sp. Leptoplax richardi n. comb
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24

Frick, Melissa. "Cholera in Present-Day Haiti: Interpretations of and Responses to a Contemporary Enemy." Swarthmore Undergraduate History Journal 1, no. 2 (2020): 94–110. http://dx.doi.org/10.24968/2693-244x.1.2.4.

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Note: In lieu of an abstract, this is the article's first paragraph. "In his introduction to Epidemics and Ideas, Paul Slack calls to revive the study of social history of epidemics, wanting to show how societies cope with, react to, and interpret crises of disease. He reviews historian Richard Evans’ notion of the “common dramaturgy” to all epidemics, which states that human society responds to mass infection through an inherent response mechanism. Disease presents common dilemmas - including decisions on how the disease is transmitted, whom it infects, who is to blame, and incites common res
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Frick, Melissa. "Cholera in Present-Day Haiti: Interpretations of and Responses to a Contemporary Enemy." Swarthmore Undergraduate History Journal, no. 2 (2020): 94–110. http://dx.doi.org/10.24968/2693-244x.2.4.

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Note: In lieu of an abstract, this is the article's first paragraph. "In his introduction to Epidemics and Ideas, Paul Slack calls to revive the study of social history of epidemics, wanting to show how societies cope with, react to, and interpret crises of disease. He reviews historian Richard Evans’ notion of the “common dramaturgy” to all epidemics, which states that human society responds to mass infection through an inherent response mechanism. Disease presents common dilemmas - including decisions on how the disease is transmitted, whom it infects, who is to blame, and incites common res
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26

Oniang'o, Ruth. "Why is agricultural research important? Why African Governments need to support it." African Journal of Food, Agriculture, Nutrition and Development 15, no. 1 (2015): 1. http://dx.doi.org/10.18697/ajfand.68.ed061.

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Surely without research and an enquiring mind, it is impossible to make much discovery. Many innovations come out of research, and an environment that allows free thinking, debates, enquiries of all sorts and all accompanied by requisite resources. Whether it is the Wright brothers with the aircraft or Thomas Edison with the ever enduring light bulb or Richard Branson with his Virgin Enterprises or Norman Borlaug with Asia's green revolution that saved billions from starvation, an enabling environment needs to be in place. If we do not support research in Africa we shall continue to blame thos
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27

Woods, Michael. "Necessity, Cause and Blame in Aristotle - Richard Sorabji: Necessity, Cause and Blame. Perspectives on Aristotle's Theory. Pp. xvii + 326; frontispiece. London: Duckworth, 1980. £24." Classical Review 35, no. 1 (1985): 71–72. http://dx.doi.org/10.1017/s0009840x00107401.

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28

Loré, John M. "Surgery of the thyroid and parathyroid glands by Blake Cady, MD and Richard L. Rossi, MD." Laryngoscope 101, no. 12 (1991): 1387–88. http://dx.doi.org/10.1002/lary.5541011224.

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29

Hager, Paul, and Michael Peters. "Symposium on Thinking Again: Education After Postmodernism by Nigel Blake, Richard Smith, Paul Standish & Paul Smeyers." Educational Philosophy and Theory 32, no. 3 (2000): 309–10. http://dx.doi.org/10.1111/j.1469-5812.2000.tb00454.x.

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30

L., J. F. "AN ENGLISH EXPERT'S VIEW OF AMERICAN "INFORMED CONSENT"." Pediatrics 88, no. 3 (1991): 489. http://dx.doi.org/10.1542/peds.88.3.489.

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Scientists also feel that overzealous ethical review boards and, in particular, informed consent rules have driven science away. In the mid-80's, Dr. Richard Peto, a well-known epidemiologist at Oxford University, approached American cardiologists to enlist patients for a study of the drug streptokinase as a treatment for heart attacks. Although the Americans were enthusiastic, in the time that British doctors referred 6,000 patients, only 400 entered from the other side of the Atlantic. He holds consent procedures largely to blame. "The American documents were three pages of legalistic junk,"
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Erlich, Lawrence B. "Book Review : Health and Social Organization By David Blane, Eric Brunner, and Richard Wilkinson. New York: Routledge, 1996." American Journal of Medical Quality 13, no. 1 (1998): 52–53. http://dx.doi.org/10.1177/106286069801300107.

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Bonastia, Chris. "Hedging His Bets." Social Science History 28, no. 1 (2004): 19–52. http://dx.doi.org/10.1017/s0145553200012736.

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Drawing on primary sources from the Nixon Presidential Materials and the Department of Housing and Urban Development (HUD), this article examines HUD's attempts during the Nixon era to implement “pro-integrative” policies and the White House response to these efforts. Specifically, this article provides an explanation for why President Richard Nixon elected to dismantle residential integration initiatives while allowing similar policies in employment and education to proceed with some force. In contrast to existing work arguing that Nixon's civil rights positions were designed to maximize poli
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Hart, John. "Presidential Lightning Rods: The Politics of Blame Avoidance. By Richard J. Ellis. Lawrence: University Press of Kansas, 1994. 262p. $29.95." American Political Science Review 89, no. 4 (1995): 1021–22. http://dx.doi.org/10.2307/2082544.

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34

Margaretha, Maria, and Sri Hastuti. "The indonesian version of irrational beliefs test in rational emotive behavior therapy: adaptation of irrational beliefs test." COUNS-EDU: The International Journal of Counseling and Education 2, no. 2 (2017): 70. http://dx.doi.org/10.23916/002017026220.

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This Indonesian version of Irrational Beliefs Test (IV-IBT) measures the irrational thoughts in accordance with the irrational beliefs concept by Albert Ellis (Rational Emotive Behavior Therapy) and is the result of the language and cultural adaptation of Irrational Beliefs Test (IBT; Richard Garner Jones, 1968). There are 10 irrational thoughts contained in IBT namely demand for approval, high self-expectation, blame proneness, frustration reactive, anxious overcome, problem avoidance, dependency, helplessness, perfectionism. IBT consist of 100 items originating from 10 items for each type of
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35

Paz, D. G. "The Age of Disraeli, 1868-1881: The Rise of Tory Democracy. Richard Shannon , John Barnes , Lord Blake , Lord Boyle , Chris Cook." Journal of Modern History 67, no. 1 (1995): 145–48. http://dx.doi.org/10.1086/245039.

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36

Priestman, Martin. "Temples and Mysteries in Romantic Infidel Writing." Romanticism on the Net, no. 25 (June 11, 2009): 0. http://dx.doi.org/10.7202/006010ar.

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Abstract Not all apparently religious imagery in Romantic Period writing is in fact religious. Temples—particularly when presided over by a priestess and linked with the ideas of reason or nature—often denote active hostility to Christianity if not to all religion. Examples from the Temple of Reason in revolutionary Paris to Shelley are considered, as well as references to Eleusinian and other Greek Mystery cults, seen as revealing hidden truths to an elite while concealing them from the masses. For Coleridge, these truths were quasi-Christian; for many others, they were materialistic and reli
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Hau, R., D. R. V. Dickens, G. R. Nattrass, M. O'Sullivan, I. P. Torode, and H. K. Graham. "Which Implant for Proximal Femoral Osteotomy in Children? A Comparison of the AO (ASIF) 90° Fixed-Angle Blade Plate and the Richards Intermediate Hip Screw." Journal of Pediatric Orthopaedics 20, no. 3 (2000): 336–43. http://dx.doi.org/10.1097/01241398-200005000-00013.

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38

Olson, Todd P. "Pitiful Relics: Caravaggio's Martyrdom of St. Matthew." Representations 77, no. 1 (2002): 107–42. http://dx.doi.org/10.1525/rep.2002.77.1.107.

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Caravaggio's seminal ambitious program in the Contarelli Chapel (San Luigi dei Francesi, Rome) representing the Calling and the Martyrdom of St. Matthew (1599-1600) invoked the threat of iconoclasm as it imagined the martyr's body as a violated relic. Counter-Reformation images and hagiographies, such as the engravings in Richard Verstegan's Thééââtre des cruautéés des hééréétiques nostre temps, traduit du latin en franççois (Anvers, 1588) and Giovanni Battista Cavalieri's Ecclesiae Anglicanae Trophaea (Rome, 1584), after paintings by Pomarancio, depicted disintegrated sacred bodies subject bo
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Baryshnikov, Vladimir N., Victor N. Borisenko, and Oleg Yu Plenkov. "Cultural Results of the Youth Revolution." Vestnik of Saint Petersburg University. History 66, no. 3 (2021): 1012–26. http://dx.doi.org/10.21638/11701/spbu02.2021.318.

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The review of the book “The Long ‘68: Radical Protest and its Enemies” by R. Vainen analyzes the contribution made by the author to the study of the problems of social disturbances in the West in 1968 and their further consequences. R. Vainen rightly points out that what happened can be likened to a world revolution — similarly to the revolution of 1848 in Europe. The author also does not hide his sympathies and dislikes, taking a very clear political position, although some of his assessments and emphasis (in particular, the arbitrary exclusion of Italy and Japan from the analysis) may cause
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Temple, Bogusia. "Book Review. Health and social organisation: towards a health policy for the twenty‐first century, edited by David Blane, Eric Brunner and Richard Wilkinson." Health Care Analysis 5, no. 4 (1997): 336. http://dx.doi.org/10.1002/(sici)1099-1042(199712)5:4<336::aid-hca246>3.0.co;2-f.

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Perdigão, Hêmille Raquel Santos. "Para cada silêncio traumático, a poesia de uma canção as performances da canção Moon River nos filmes de Almodóvar e Blake Edwards." Muiraquitã: Revista de Letras e Humanidades 12, no. 2 (2024): 213–37. https://doi.org/10.29327/210932.12.2-15.

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No filme La mala educación (2004), de Pedro Almodóvar, um importante personagem é o diretor de cinema Enrique Goded que, no início do enredo, planejando uma adaptação fílmica, inicia a leitura do conto La Visita, escrito por seu amigo de infância Ignácio. Imediatamente aparecem, em uma prévia, as cenas de seu futuro filme, dentre as quais a performance da canção Moon River, de Mancini e Mercer, como adaptação da narrativa de um estupro sofrido por Ignácio quando criança. A canção foi originalmente performada por Audrey Hepburn no filme Breakfast at Tiffany's (1961), de Blake Edwards, e reapare
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Fink, Robert. ""Rigoroso (♪ = 126)": "The Rite of Spring" and the Forging of a Modernist Performing Style." Journal of the American Musicological Society 52, no. 2 (1999): 299–362. http://dx.doi.org/10.2307/832000.

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It is only recently that we have begun to consider modernist performing style-especially its brisk, unyielding tempos and abhorrence of "expressive" rubato-as a historical phenomenon. Much of the credit (or blame) for this style has been ascribed to the composer of The Rite of Spring; Richard Taruskin argues that "all truly modern musical performance... treats the music performed as if it were composed-or at least performed-by Stravinsky." But the performing history of the Rite shows that the composer struggled mightily to get his own music played "as if composed by Stravinsky." Early interpre
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43

Weiss, Peter Eliot. "Rewriting Hamlet." Canadian Theatre Review 54 (March 1988): 18–23. http://dx.doi.org/10.3138/ctr.54.004.

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First of all it’s important to recognize the fact that Vancouver is a town where educated and aware people think it’s clever to say that Shakespeare’s a bore. Vancouver theatre is entertainment theatre, like it or lump it, and even the greatest of plays must be made to conform. Hence, Richard Ouzounian, doing his M.A. thesis production at U.B.C. in 1972, was able to launch a stellar career by marrying Sondheim and the Marx brothers to Beatrice and Benedict in a production of Much Ado About Nothing, to set a tone for directorial approach that Vancouver theatre has still not been able to get pas
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Fraser, K. C. "The Illustrated Companion to Nelson’s Navy2000235Nicholas Blake, Richard Lawrence. The Illustrated Companion to Nelson’s Navy. London: Chatham Publishing 1999. 208 pp, ISBN: 1 86176 090 6 £25.00." Reference Reviews 14, no. 5 (2000): 24. http://dx.doi.org/10.1108/rr.2000.14.5.24.235.

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Reynaud, Daniel. "Religion in the British Navy, 1815–1879. Piety and professionalism. By Richard Blake. Pp. xii + 281. Woodbridge: The Boydell Press, 2014. £75. 978 1 84383 885 2." Journal of Ecclesiastical History 66, no. 3 (2015): 671–73. http://dx.doi.org/10.1017/s002204691500007x.

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46

Sutton, Peter. "Operation Pollinator: Positive Action for Pollinators and Improved Biodiversity on Farm." Outlooks on Pest Management 31, no. 3 (2020): 121–25. http://dx.doi.org/10.1564/v31_jun_07.

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Operation Pollinator is an industry led initiative. This biodiversity enhancement programme has enabled better engagement and training of farmers in the delivery of high quality wildlife habitats as part of their national agri-environment schemes (AES). This overview presents findings from farm-scale studies that have shown the type and scale of effects required to deliver such benefits on farm and across the landscape. Significant efforts have already been made to promote biodiversity on farmland, but these results show that to improve the agricultural landscape really, we need to implement m
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Gudmundsson, H. "Life History Patterns of Polychaete Species of the Family Spionidae." Journal of the Marine Biological Association of the United Kingdom 65, no. 1 (1985): 93–111. http://dx.doi.org/10.1017/s0025315400060835.

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The reproductive morphology and larval development in Spionidae has been dealt with extensively by Soderström (1920), Hannerz (1956), Orrhage (1964). Simon (1967), Blake (1969) and Rice (1980). The family shows a considerable variation in gamete morphology, modes of sperm transfer and types of larval development. One might also expect variability in features of the life history patterns, such as the life span, reproductive age, reproductive cycles and fecundity, both between and within species.Previous population studies on spionids include the work on populations of Polydora ciliata (Johnston
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Lembang, Supeno. "Relasi Nietzsche dengan Paulus." Lumen Veritatis: Jurnal Filsafat dan Teologi 15, no. 1 (2024): 73–83. http://dx.doi.org/10.30822/lumenveritatis.v15i1.3080.

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Nietzsche’s relation with Christianity, on the the surface, easily defined as antipodal, full of animosity. It is not a simple task to specify which Christianity that can represent a stable concept of Christianity. Numerous branches as well as different school of thoughts in the body of Christianity. Nietzsche had his own view on certain Christianity (coloured by his Lutheran Protestant), he was not seldom launched attack after attack to Christianity and blame it as caused of Nihilism in Europe. Christianity according to his view has become one of the obstacles that hindered the arrival of the
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49

Khanna, D., J. Pope, M. Matucci-Cerinic, et al. "OP0249 LONG-TERM EXTENSION RESULTS OF RISE-SSC, A RANDOMIZED TRIAL OF RIOCIGUAT IN PATIENTS WITH EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 156.2–157. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3671.

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Background:RISE-SSc (NCT02283762) was a multicenter Phase IIb trial of riociguat in pts with early (duration ≤18 months) dcSSc and modified Rodnan skin score (mRSS) 10−22 units. Pts were randomized double-blind to placebo or riociguat 0.5–2.5 mg t.i.d. for 52 weeks. The primary endpoint, mRSS change from baseline to Week (Wk) 52, did not reach statistical significance (p=0.08, riociguat vs placebo), but there were favorable trends in some other outcomes.Objectives:To present open-label long-term extension (LTE) results of RISE-SSc.Methods:Pts who completed Wk 52 of double-blind therapy could e
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Distler, O., F. Kramer, J. Höfler, et al. "FRI0575 BIOMARKER ANALYSIS FROM THE RISE-SSC STUDY OF RIOCIGUAT IN EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 890–91. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3138.

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Background:RISE-SSc (NCT02283762) was a multicenter, double-blind, Phase IIb study of riociguat in early dcSSc. Primary endpoint was change in mRSS from baseline to Wk 52.Objectives:Exploratory, descriptive analyses of riociguat target engagement and effects on disease biomarkers in RISE-SSc and their relationship with effects on the primary endpoint. All biomarker p-values are for information only.Methods:Pts with dcSSc (duration ≤18 mo; modified Rodnan skin score [mRSS] 10–22 units) were randomized to riociguat 0.5−2.5 mg tid (n=60) or placebo (n=61). Biomarkers of target engagement (cGMP),
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