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Journal articles on the topic 'BlaNDM-1 gene'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Xin, Xueqiang, Yi Yin, Jiayong Kong, Mianzhi Wang, Zhiqiang Wang та Ruichao Li. "Genomic Insights into Carbapenem-Resistant Organisms Producing New Delhi Metallo-β-Lactamase in Live Poultry Markets". Microorganisms 13, № 6 (2025): 1195. https://doi.org/10.3390/microorganisms13061195.

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New Delhi metallo-β-lactamase (NDM) is an enzyme that can degrade a wide range of β-lactam antibiotics. The widespread dissemination of the blaNDM gene, which encodes NDM, in animal-derived settings poses a threat to public health security. Live poultry markets represent critical nodes in public health surveillance. However, there is currently limited reporting on the spread of the blaNDM gene within these markets under the One Health approach. This study investigated the prevalence of the blaNDM gene in live poultry markets and, by integrating newly sequenced genomes with publicly available d

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Kong, Ling-Han, Rong Xiang, Yu-Long Wang, et al. "Integration of the blaNDM-1 carbapenemase gene into a novel SXT/R391 integrative and conjugative element in Proteus vulgaris." Journal of Antimicrobial Chemotherapy 75, no. 6 (2020): 1439–42. http://dx.doi.org/10.1093/jac/dkaa068.

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Abstract Objectives To characterize the genetic environment of the carbapenem resistance determinant in Proteus vulgaris of swine origin. Methods The carbapenem-resistant P. vulgaris strain BC22 was isolated from a faecal swab from a diseased pig with diarrhoea in Sichuan Province of China in 2018. The presence of carbapenemase genes was screened by PCR. WGS and bioinformatics analysis were performed to analyse the genetic environment of the carbapenem resistance determinant. Results P. vulgaris strain BC22 was found to harbour the carbapenemase gene blaNDM-1. WGS data revealed that blaNDM-1 w

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Bello-López, Elena, Ángeles Pérez-Oseguera, Walter Santos, and Miguel Ángel Cevallos. "A novel replication initiation region encoded in a widespread Acinetobacter plasmid lineage carrying a blaNDM-1 gene." PLOS ONE 19, no. 5 (2024): e0303976. http://dx.doi.org/10.1371/journal.pone.0303976.

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The blaNDM-1 gene and its variants encode metallo-beta-lactamases that confer resistance to almost all beta-lactam antibiotics. Genes encoding blaNDM-1 and its variants can be found in several Acinetobacter species, and they are usually linked to two different plasmid clades. The plasmids in one of these clades contain a gene encoding a Rep protein of the Rep_3 superfamily. The other clade consists of medium-sized plasmids in which the gene (s) involved in plasmid replication initiation (rep)have not yet been identified. In the present study, we identified the minimal replication region of a b

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Naeem, Sohni, Hazrat Bilal, Hafsah Muhammad, et al. "Detection of blaNDM-1 gene in ESBL producing Escherichia coli and Klebsiella pneumoniae isolated from urine samples." Journal of Infection in Developing Countries 15, no. 04 (2021): 516–22. http://dx.doi.org/10.3855/jidc.12850.

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Introduction: Enterobacteriaceae such as Escherichia coli and Klebsiella pneumoniae are the most prominent bacterial species resistant to almost all commonly used antibiotics. Carbapenem is one of the last resort drugs for treating such emerging multidrug-resistant bacteria. This study aimed to detect carbapenem-resistant blaNDM-1 gene in ESBL producing E. coli and K. pneumoniae isolates. Methodology: A total of 190 E. coli and 350 K. pneumoniae isolates were screened for extended spectrumβ-lactamase (ESBL), carbapenemase and metallo β-lactamase (MBL) production via double-disk synergy t

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Hussein, Zeyad, Haider Kadhim, and Jabbar Hassan. "DETECTION OF NEW DELHI METALLO-BETA-LACTAMASE-1 (BLANDM-1) IN CARBAPENEM-RESISTANT PSEUDOMONAS AERUGINOSA ISOLATED FROM CLINICAL SAMPLES IN WASIT HOSPITALS." Iraqi Journal of Medical Sciences 16, no. 3 (2018): 239–46. http://dx.doi.org/10.22578/ijms.16.3.3.

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Background:Pseudomonas aeruginosa (P. aeruginosa) infections are clinical problem, it is a difficult to treat because of high resistant to many antibiotics (Multi-drug resistant) and a high risk of emergence of resistance during therapy. Carbapenems are therapeutic choice against infections caused by Gram-negative bacilli including strains of P. aeruginosa. New Delhi metallo-β-lactamase-1 (blaNDM-1) gene, an acquired class B carbapenemase. Dissemination predominantly involves transfer of the blaNDM-1 gene among promiscuous plasmids and clonal outbreaks. Bacteria with NDM-1 are typically resist

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Bilal, Hazrat, Gaojian Zhang, Tayyab Rehman, et al. "First Report of blaNDM-1 Bearing IncX3 Plasmid in Clinically Isolated ST11 Klebsiella pneumoniae from Pakistan." Microorganisms 9, no. 5 (2021): 951. http://dx.doi.org/10.3390/microorganisms9050951.

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The New Delhi Metallo-β-lactamase (NDM) is among the most threatening forms of carbapenemases produced by K. pneumoniae, well-known to cause severe worldwide infections. The molecular epidemiology of blaNDM-1-harboring K. pneumoniae is not well elucidated in Pakistan. Herein, we aim to determine the antibiotics-resistance profile, genes type, molecular type, and plasmid analysis of 125 clinically isolated K. pneumoniae strains from urine samples during July 2018 to January 2019 in Pakistan. A total of 34 (27.2%) K. pneumoniae isolates were carbapenemases producers, and 23 (18.4%) harbored the

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Tsilipounidaki, Katerina, Christos-George Gkountinoudis, Zoi Florou, George C. Fthenakis, Vivi Miriagou, and Efthymia Petinaki. "The Molecular Characterization of blaNDM-1-Positive Acinetobacter baumannii Isolated in Central Greece." Microorganisms 11, no. 10 (2023): 2588. http://dx.doi.org/10.3390/microorganisms11102588.

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The objective of the present study is to report the detection and the molecular characterization of nine blaNDM-1-positive Acinetobacter baumannii isolates, which were isolated from patients in a tertiary care hospital in Central Greece from December 2022 to August 2023. The isolates were characterized by whole genome sequencing to obtain Pasteur multilocus sequencing typing (MLST) and to identify the blaNDM-1-environment, resistome, and virulence genes content. In silico MLST analysis showed that the isolates belonged to four different clones (STs 160, 2, 85, and 2493). All strains, apart fro

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Chen, Wenxin, Zhihong Liu, Hongguang Lin, et al. "Occurrence of blaNDM-1-Positive Providencia spp. in a Pig Farm of China." Antibiotics 11, no. 6 (2022): 713. http://dx.doi.org/10.3390/antibiotics11060713.

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Antibiotics have been extensively used to ensure the productivity of animals on intensive livestock farms. Accordingly, antimicrobial-resistant organisms, which can be transmitted to humans via the food chain, pose a threat to public health. The Enterobacterium antimicrobial resistance gene, blaNDM-1, is a transmissible gene that has attracted widespread attention. Here, we aimed to investigate the prevalence of Enterobacteriaceae carrying blaNDM-1 on an intensive pig farm. A total of 190 samples were collected from a pig farm in Hunan Province, China. Resistant isolates were selected using Ma

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Tanni, Afroza Akter, Md Mahbub Hasan, Nahid Sultana, Wazir Ahmed, and Adnan Mannan. "Prevalence and molecular characterization of antibiotic resistance and associated genes in Klebsiella pneumoniae isolates: A clinical observational study in different hospitals in Chattogram, Bangladesh." PLOS ONE 16, no. 9 (2021): e0257419. http://dx.doi.org/10.1371/journal.pone.0257419.

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Objective This study was performed to investigate the prevalence of multidrug resistance and molecular characterization of Klebsiella pneumoniae (KPN) from clinical isolates in the southern region of Bangladesh. Additional analysis of the prevalence of blaNDM-1, blaSHV-11, uge genes of KPN was also carried out among these clinical isolates. Method The study was carried out using 1000 clinical isolates collected from two different hospitals of Chattogram. A drug susceptibility test was performed by the disk diffusion method to detect KPN’s response to 16 antibiotics. The presence of antibiotic-

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Tula, M. Y., O. I. Enabulele, E. A. Ophori, R. O. Okojie та F. Joel. "Emergence of New Delhi metallo-β-lactamase-1 (NDM-1) producing Enterobacterales from water sources: An impending public health challenge in Adamawa-north senatorial zone, Nigeria". African Journal of Clinical and Experimental Microbiology 24, № 3 (2023): 258–65. http://dx.doi.org/10.4314/ajcem.v24i3.5.

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Background: The emergence of New Delhi metallo-beta-lactamase-1 (NDM-1) among Enterobacterales in water sources has raised a major public health concern and constitute critical threat to human health as these organisms exhibits high level of resistance to available potent antibiotics. The aim of this study is to detect the presence of NDM-1 gene among carbapenem resistant Enterobacterales (CRE) isolates from water sources. Methodology: A total of 256 water samples were collected from randomly selected hand-dug wells (128 samples) and river/stream (128 samples) for each of dry and rainy s

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Rajkumar, Kalyan, Shruti Radera, Jyotsna Agarwal, and Mastan Singh. "Superbugs causing infections at a tertiary care hospital and the return of pre-antibiotic era!" Asian Journal of Medical Sciences 7, no. 2 (2015): 76–79. http://dx.doi.org/10.3126/ajms.v7i2.12750.

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Aims and Objectives: Increase in the incidence of Escherichia coli and Klebsiella pneumoniae carrying New Delhi metallo beta lactamase-1 (NDM-1) gene are called superbugs is of great concern as presence of blaNDM-1 gene makes E.coli and K.pneumoniae highly resistant to most of currently available antibiotics. This study was planned to observe the burden of blaNDM-1 gene carrying E. coli and K.pneumoniae at a tertiary care hospital in northern India. Materials and Methods: A total of 1709 E. coli and 327 K. pneumonia nonrepitive isolates were taken from various clinical samples received in a te

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Naim, Huma, Meher Rizvi, Mohd Azam, et al. "Alarming emergence, molecular characterization, and outcome of blaNDM-1 in patients infected with multidrug-resistant Gram-negative bacilli in a tertiary care hospital." Journal of Laboratory Physicians 9, no. 03 (2017): 170–76. http://dx.doi.org/10.4103/0974-2727.208264.

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Abstract INTRODUCTION: This study was conducted to assess the prevalence of metallo-beta-lactamases (MBLs) in general and blaNDM-1 in particular. It also aimed at evaluating clinical characteristics and outcome in patients infected with MBLs. MATERIALS AND METHODS: A total of 116 carbapenem-resistant Gram-negative bacilli (CRGNB) were evaluated in the study. These CRGNB were tested for MBL production both phenotypically for MBLs and genotypically for blaNDM-1 gene by polymerase chain reaction (PCR). Representative stains of NDM-1 isolates were further sequenced by Triyat Scientific Co., (Nagpu

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Kumari, Manisha, Narayan Raj Bhattarai, Keshav Rai, Tejendra Kumar Pandit, and Basudha Khanal. "Multidrug-Resistant Acinetobacter: Detection of ESBL, MBL, blaNDM-1 Genotype, and Biofilm Formation at a Tertiary Care Hospital in Eastern Nepal." International Journal of Microbiology 2022 (December 10, 2022): 1–9. http://dx.doi.org/10.1155/2022/8168000.

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Background. The Acinetobacter species is an important hospital-acquired pathogen. The rapid development of resistance to multiple drugs and the ability to form biofilm make these bacteria more adaptable to survive in healthcare facilities, thus posing a challenge to their effective management. Objective. This study aimed to characterize clinical isolates of Acinetobacter spp and to study their antimicrobial susceptibility patterns and ability to form biofilm. Resistant Acinetobacter was further analyzed for the detection of extended-spectrum β-lactamases (ESBLs), metallo β-lactamases (MBLs), c

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Espedido, Björn A., Borce Dimitrijovski, Sebastiaan J. van Hal, and Slade O. Jensen. "The use of whole-genome sequencing for molecular epidemiology and antimicrobial surveillance: identifying the role of IncX3 plasmids and the spread of blaNDM-4-like genes in the Enterobacteriaceae." Journal of Clinical Pathology 68, no. 10 (2015): 835–38. http://dx.doi.org/10.1136/jclinpath-2015-203044.

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AimsTo characterise the resistome of a multi-drug resistant Klebsiella pneumoniae (Kp0003) isolated from an Australian traveller who was repatriated to a Sydney Metropolitan Hospital from Myanmar with possible prosthetic aortic valve infective endocarditis.MethodsKp0003 was recovered from a blood culture of the patient and whole genome sequencing was performed. Read mapping and de novo assembly of reads facilitated in silico multi-locus sequence and plasmid replicon typing as well as the characterisation of antibiotic resistance genes and their genetic context. Conjugation experiments were als

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Meletis, Georgios, Andigoni Malousi, Areti Tychala, et al. "Probable Three-Species In Vivo Transfer of blaNDM-1 in a Single Patient in Greece: Occurrence of NDM-1-Producing Klebsiella pneumoniae, Proteus mirabilis, and Morganella morganii." Antibiotics 12, no. 7 (2023): 1206. http://dx.doi.org/10.3390/antibiotics12071206.

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NDM carbapenemase-encoding genes disseminate commonly among Enterobacterales through transferable plasmids carrying additional resistance determinants. Apart from the intra-species dissemination, the inter-species exchange of plasmids seems to play an additional important role in the spread of blaNDM. We here present the genetics related to the isolation of three species (Klebsiella pneumoniae, Proteus mirabilis, and Morganella morganii) harboring the blaNDM-1 gene from a single patient in Greece. Bacterial identification and antimicrobial susceptibility testing were performed using the Vitek2

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Sud, Anuj, Beena Uppal, Swati Sharma, Prabhav Aggarwal, and Rakesh Kumar. "Probable Treatment Options against Infections with Bacteria Carrying blaNDM-1 Gene." International Journal of Current Microbiology and Applied Sciences 6, no. 12 (2017): 2803–6. http://dx.doi.org/10.20546/ijcmas.2017.612.325.

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Ong, D. C. T., T. H. Koh, N. Syahidah, P. Krishnan, and T. Y. Tan. "Rapid detection of the blaNDM-1 gene by real-time PCR." Journal of Antimicrobial Chemotherapy 66, no. 7 (2011): 1647–49. http://dx.doi.org/10.1093/jac/dkr184.

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Chatterjee, Somdatta, Ayan Mondal, Shravani Mitra, and Sulagna Basu. "Acinetobacter baumannii transfers the blaNDM-1 gene via outer membrane vesicles." Journal of Antimicrobial Chemotherapy 72, no. 8 (2017): 2201–7. http://dx.doi.org/10.1093/jac/dkx131.

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Wu, Zhaomeng, Ronghui Gou, Longhua Sha, Chunfang Yu, Lixue Meng, and Zhixiong Jin. "Effects of Luteolin-7-O-Glucoside on Intestinal Microbiota Dysbiosis and Drug Resistance Transmission Caused by Raoultella Ornithinolytica B1645-1: Modulating the Composition of Intestinal Microbiota and Promoting the Transfer of blaNDM-1 Gene from Genus Enterococcus to Lactobacillus in Mice." Microorganisms 11, no. 10 (2023): 2477. http://dx.doi.org/10.3390/microorganisms11102477.

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Raoultella ornithinolytica is an Enterobacteriaceae bacterium that can infect both humans and animals, while luteolin-7-O-glucoside (IOG) is a flavonoid that has broad effects on the intestinal microbiota of healthy animals. However, current studies lack sufficient data on intestinal microbiota dysbiosis and drug resistance transmission caused by R. ornithinolytica and the possible role of IOG. In this study, BALB/c mice were infected with R. ornithinolytica carrying blaNDM-1 gene and treated with IOG (3 mg/kg·d and 6 mg/kg·d) to analyze the diversity of intestinal microbiota and the transfer

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Divyashree, M., Madhu K. Mani, and Shama Prakash K. "Detection and Real-time PCR Assay for the Quantification of Carbapenemase Gene blablaNDM-1 in Hospital Effluent." Journal of Pure and Applied Microbiology 15, no. 4 (2021): 2403–8. http://dx.doi.org/10.22207/jpam.15.4.65.

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This study aims to isolate gram-negative bacteria (GNB) harboring the gene NDM-1 from the tertiary care hospital effluents. Also, aims to evaluate the relative copy number of blaNDM-1 carried by the positive isolates. The study isolated 215 GNB from 40 effluent samples. The antibiotic susceptibility tests for carbapenems were performed using disc diffusion assay. The isolates resistant to either meropenem or imipenem were checked for the existence of MBL by phenotypic methods. The isolates carrying NDM-1 gene were genotypically confirmed by Polymerase chain reaction (PCR). The gene copy number

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Alshahrani, Abdullah M., Mutasim E. Ibrahim, Ahmed K. Aldossary, Mushabab A. Alghamdi, Omar B. Ahmed, and Aref A. Bin Abdulhak. "Molecular Epidemiology of Carbapenem-Resistant K. pneumoniae Clinical Isolates from the Adult Patients with Comorbidities in a Tertiary Hospital, Southern Saudi Arabia." Antibiotics 11, no. 12 (2022): 1697. http://dx.doi.org/10.3390/antibiotics11121697.

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Hospitalized patients are likely to have chronic illnesses and are at an increased risk of mortality due to infection caused by MDR bacteria. We aimed to identify carbapenem-resistant genes carrying Klebsiella pneumoniae (K. pneumoniae) isolates and their risk factors recovered from adult patients with comorbidities. A cross-sectional study was carried out between April 2021 and December 2021 at King Abdullah Hospital (KAH) in Bisha province, Saudi Arabia. Seventy-one multi-drug resistant K. pneumoniae recovered from clinical samples and screened for carbapenemase genes of blaOXA-48-like, blaN

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Boralli, Camila Maria dos Santos, Julian Andres Paganini, Rodrigo Silva Meneses, et al. "Characterization of blaKPC-2 and blaNDM-1 Plasmids of a K. pneumoniae ST11 Outbreak Clone." Antibiotics 12, no. 5 (2023): 926. http://dx.doi.org/10.3390/antibiotics12050926.

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The most common resistance mechanism to carbapenems is the production of carbapenemases. In 2021, the Pan American Health Organization warned of the emergence and increase in new carbapenemase combinations in Enterobacterales in Latin America. In this study, we characterized four Klebsiella pneumoniae isolates harboring blaKPC and blaNDM from an outbreak during the COVID-19 pandemic in a Brazilian hospital. We assessed their plasmids’ transference ability, fitness effects, and relative copy number in different hosts. The K. pneumoniae BHKPC93 and BHKPC104 strains were selected for whole genome

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Ma, Jiangang, Biao Tang, Jiahui Lin, et al. "Genome Assessment of Carbapenem- and Colistin-Resistant Escherichia coli from Patients in a Sentinel Hospital in China." Cells 11, no. 21 (2022): 3480. http://dx.doi.org/10.3390/cells11213480.

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Antimicrobial-resistant (AMR) pathogens are a significant threat to public health worldwide. However, the primary carrier of AMR genes, particularly against last-resort antibiotics, is still only partially studied in Chinese hospitals. In a sentinel hospital in China, we collected 157 E. coli strains from patients between January and July 2021. One blaNDM-1-, nine blaNDM-5-, and one mcr-1-positive E. coli recovered from inpatients were identified as resistant to meropenem and colistin. There are 37 virulence genes discovered in the 11 strains, including astA in strain EC21Z-147 (O128: H4), whi

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Shi, Qiucheng, Xinhong Han, Qin Huang, et al. "The Genetic Characteristics and Carbapenem Resistance Mechanism of ST307 Klebsiella pneumoniae Coharbouring blaCMY-6, blaOXA-48, and a Truncated blaNDM-1." Antibiotics 11, no. 11 (2022): 1616. http://dx.doi.org/10.3390/antibiotics11111616.

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Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a common nosocomial pathogen causing severe infectious diseases, and ST307 CRKP is an emerging clone. In this study, we collected five ST307 CRKP isolates, evaluated their antimicrobial susceptibility using microbroth dilution, and their clonality and population structure by PFGE, cgMLST, and SNP-based phylogenetic analysis. Then, the genome characteristics, such as antimicrobial resistance genes and plasmid profiles, were studied by subsequent genomic analysis. The plasmid transfer ability was evaluated by conjugation, and the carbapenem re

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Varghese, Angel, Jeppu Udayalaxmi, Pooja Rao, and Ethel Suman. "Blood Stream Infections caused by Non-Fermenting Gram Negative Bacilli, Clinical Correlation, MIC for Colistin, Gene Detection." Journal of Pure and Applied Microbiology 14, no. 3 (2020): 2017–25. http://dx.doi.org/10.22207/jpam.14.3.41.

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To study the risk factors and outcome of blood stream infection caused by non-fermenting gram negative bacilli (NFGNB) and their pattern of antibiotic susceptibility and genes. We included sepsis cases with blood culture positive for NFGNB. MIC for colistin was determined by broth microdilution method. Multiplex PCR was used to detect BlaIMP, BlaVIM, BlaKPC, BlaNDM-1 genes in cephalosporin and carbapenems resistant Acinetobacter spp. isolates. Out of 4,664 cases of sepsis, 50 (1.07%) were positive for NFGNB. Acinetobacter spp. 29 (58%) was the predominant isolate, of which 16 (55.17%) isolates

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Potron, Anaïs, Laurent Poirel, and Patrice Nordmann. "Plasmid-mediated transfer of the blaNDM-1 gene in Gram-negative rods." FEMS Microbiology Letters 324, no. 2 (2011): 111–16. http://dx.doi.org/10.1111/j.1574-6968.2011.02392.x.

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Lv, Dongyue, Ran Duan, Rong Fan, et al. "blaNDM and mcr-1 to mcr-5 Gene Distribution Characteristics in Gut Specimens from Different Regions of China." Antibiotics 10, no. 3 (2021): 233. http://dx.doi.org/10.3390/antibiotics10030233.

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Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of mcr and blaNDM in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments, human diarrhea patients, and wild animals from 10 regions, between 2010–2020. The positive rate was 5.09% (356/6991) for mcr and 0.41% (29/6991) for blaNDM, as detected in gut specimens from seven regions, throughout 2010 to 2019, but not detected in 2020. The detection rate of mcr showed significant differences among various sources: livestock

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Diaconu, Elena L., Virginia Carfora, Patricia Alba, et al. "Novel IncFII plasmid harbouring blaNDM-4 in a carbapenem-resistant Escherichia coli of pig origin, Italy." Journal of Antimicrobial Chemotherapy 75, no. 12 (2020): 3475–79. http://dx.doi.org/10.1093/jac/dkaa374.

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Abstract Objectives To the best of our knowledge, we describe the first evidence in Europe of an MDR, blaNDM-4-positive Escherichia coli isolated from a food-producing animal, harboured by a novel IncFII plasmid of which we report the complete sequence. Methods One blaNDM-4-positive E. coli isolated in 2019 from the caecal contents of a fattening pig in Italy was in-depth characterized by combined bioinformatic analysis of Oxford Nanopore long reads and Illumina short reads, for in silico typing, determination of the blaNDM-4 genetic context and full reconstruction of the blaNDM-4–carrying pla

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Peng, Hu, Li, et al. "Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene." Microorganisms 7, no. 11 (2019): 558. http://dx.doi.org/10.3390/microorganisms7110558.

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Enterobacteriaceae having chromosomally-encoded mcr-1 is rarely reported. In this study, we recovered a chromosomal mcr-1 carrying Escherichia coli, designated HeN100, from the feces of a diarrheal pig in China. Antimicrobial susceptibility testing showed that HeN100 was resistant to three aminoglycosides, twelve β-lactams including three carbapenems, one phenicol, two tetracyclines, two fluoroquinolones, nitrofurantoin, and colistin tested. Oxford Nanopore MinION sequencing revealed that the complete genomes of the multidrug resistant (MDR) HeN100 consisted of a single circular chromosome and

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Hirabayashi, Aki, Koji Yahara, Satomi Mitsuhashi та ін. "Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam". PLOS ONE 16, № 7 (2021): e0231119. http://dx.doi.org/10.1371/journal.pone.0231119.

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Carbapenem-resistant Enterobacterales (CRE) represent a serious threat to public health due to the lack of treatment and high mortality. The rate of antimicrobial resistance of Enterobacterales isolates to major antimicrobials, including carbapenems, is much higher in Vietnam than in Western countries, but the reasons remain unknown due to the lack of genomic epidemiology research. A previous study suggested that carbapenem resistance genes, such as the carbapenemase gene blaNDM, spread via plasmids among Enterobacterales in Vietnam. In this study, we characterized blaNDM-carrying plasmids in

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Song, Huijuan, Siyu Zou, Yi Huang, et al. "Salmonella Typhimurium with Eight Tandem Copies of blaNDM-1 on a HI2 Plasmid." Microorganisms 12, no. 1 (2023): 20. http://dx.doi.org/10.3390/microorganisms12010020.

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Carbapenem-resistant Salmonella has recently aroused increasing attention. In this study, a total of four sequence type 36 Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) isolates were consecutively isolated from an 11-month-old female patient with a gastrointestinal infection, of which one was sensitive to carbapenems and three were resistant to carbapenems. Via antibiotic susceptibility testing, a carbapenemases screening test, plasmid conjugation experiments, Illumina short-reads, and PacBio HiFi sequencing, we found that all four S. Typhimurium isolates contained a

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Costa, Jackeliny dos Santos, Thalita Priscila Peres Seabra Da Cruz, Larissa Viera Da Costa, et al. "Ocorrência de genes de resistência metalo-beta-lactamases em isolados de Pseudomonas aeruginosa MDR de otites de cão, Brasil." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21, no. 8 (2023): 8722–34. http://dx.doi.org/10.55905/oelv21n8-049.

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A Pseudomonas aeruginosa é uma bactéria oportunista, considerada um dos principais agentes de infecção nosocomial em hospitais associada múltipla resistência a antimicrobianos. Em animais, principalmente cães, a otite é uma enfermidade de grande incidência associado a P. aeruginosa. A ocorrência de isolados multirresistentes a metalo beta lactamase com presença de genes blaIMP-1, blaVIM-2, blaSPM-1 e blaNDM-1 tem sido bem descrita em isolados humanos entretanto a ocorrência em animais são escassos. O objetivo deste trabalho foi a detecção dos genes de metalo-beta-lactamses em isolados de P. ae

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LI, TIAN-JIAO, CHEN-XUE LI, SHU-PING CHENG, et al. "Separation and confirmation of nine Enterobacteriaceae strains that carry the blaNDM-1 gene." Experimental and Therapeutic Medicine 9, no. 4 (2015): 1241–46. http://dx.doi.org/10.3892/etm.2015.2255.

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Datta, S., S. Mitra, S. Chatterjee, and S. Basu. "Emergence, spread and exchange of blaNDM-1 gene among Enterobacteriaceae in septicaemic neonates." International Journal of Infectious Diseases 45 (April 2016): 71–72. http://dx.doi.org/10.1016/j.ijid.2016.02.204.

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Shafiq, Muhammad, Iftikhar Ahmed, Muhammad Saeed, et al. "Predominance of blaNDM- and blaIMP-Harboring Escherichia coli Belonging to Clonal Complexes 131 and 23 in a Major University Hospital." Medicina 60, no. 9 (2024): 1528. http://dx.doi.org/10.3390/medicina60091528.

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Background and Objectives: Carbapenem resistance is a growing global challenge for healthcare, and, therefore, monitoring its prevalence and patterns is crucial for implementing targeted interventions to mitigate its impact on patient outcomes and public health. This study aimed to determine the prevalence of carbapenem resistance among Escherichia coli (E. coli) strains in the largest tertiary care hospital of the capital territory of Pakistan and to characterize the isolates for the presence of antimicrobial resistance genes. Additionally, the most prevalent sequence types were analyzed. Mat

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Cortés-Ortíz, Iliana Alejandra, Julio Cesar Juárez-Gómez, Concepción Cu-Quijano, et al. "Klebsiella pneumoniae blaNDM-1 carrying a class 1 integron causing a hospital outbreak in a Mexican attention center." Journal of Infection in Developing Countries 15, no. 05 (2021): 657–64. http://dx.doi.org/10.3855/jidc.12996.

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Introduction: Infections acquired in hospitals are the cause of high morbidity and mortality and with the emergence of resistant bacteria, the problem is greater. The aim of this work was to determine the genetic characteristics and timeline of Klebsiella pneumoniae blaNDM-1 carrying a class 1 integron involved in an intrahospital outbreak. Methodology: Investigation was made from the first detection of K. pneumoniae blaNDM-1, strain “466”, and the last clone “423”. 16S rRNA gene analysis showed that 466 strain and clones were related to K. pneumoniae. Extended-spectrum β-lactamases (ESB

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Lopes, Maria Carolina Soares, Bruna Helena Silva Rendall Évora, Claúdio Bruno Silva de Oliveira, Emília Sousa de Oliveira, and Maria Celeste Nunes de Melo. "Co-production of blaNDM-1 and blaOXA-23 in multiresistant clinical isolates of Acinetobacter baumannii from Brazil." Research, Society and Development 11, no. 9 (2022): e6511931253. http://dx.doi.org/10.33448/rsd-v11i9.31253.

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Acinetobacter baumannii is a common and dangerous non-fermenting gram-negative bacillus due to its various and increasing resistance mechanisms. Therefore, the objective of the work was to describe four NDM-1 -producing Acinetobacter isolates from Natal, northeastern Brazil. These four isolates were identified as Acinetobacter baumannii by MALDI-TOF. All isolates were characterized by antimicrobial susceptibility testing, with resistance to all β-lactams including carbapenems and positive for the synergy test with Ethylenediaminetetraacetic acid. PCR analysis was also performed for blaNDM-1, b

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Sabrina, Tia, Erizka Rivani, and Venny Patricia. "Analisis Gen Blavim, Blandm dan Blaimp Carbapenemase dengan Alat Otomatis Vitek-2 dan Metode Polymerase Chain Reaction (PCR) pada Isolat Bakteri Enterobacteriaceae di RSUP Dr. Moh. Hoesin Palembang." SRIWIJAYA JOURNAL OF MEDICINE 1, no. 2 (2018): 84–88. http://dx.doi.org/10.32539/sjm.v1i2.12.

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Enterobacteriaceae is a normal flora in human intestinal tract which the most frequently caused the disease in human. Carbapenem is the last lines of antibiotic which used to treat severe infection that caused by gram-negative bacili bacteria, for example Enterobacteriaceae, but there is an increase prevalency of infection which caused by Carbapenem Resistant Enterobacteriaceae (CRE). The gene that encoding CRE is blaVIM, blaNDM, and blaIMP gene. The detection of these genes are very important to prevent spreading the nosocomial infection at hospital. The samples are from the speciment which h

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Ma, Ke, Yu Feng, Lu Liu, Zhihong Yao, and Zhiyong Zong. "A Cluster of Colistin- and Carbapenem-Resistant Klebsiella pneumoniae Carrying blaNDM-1 and mcr-8.2." Journal of Infectious Diseases 221, Supplement_2 (2019): S237—S242. http://dx.doi.org/10.1093/infdis/jiz519.

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Abstract Background Klebsiella pneumoniae resistant to both carbapenems and colistin imposes severe challenges for management. In this study, we report a cluster of 5 carbapenem-resistant K pneumoniae clinical strains belonging to ST1 and K57 types, 4 of which were also resistant to colistin, from 2 hospitals. Methods The 5 strains were subjected to whole-genome sequencing (WGS) using the short-read Illumina HiSeq platform, and 2 strains were also selected for long-read WGS using MinION. Clonal relatedness of the 5 strains was determined based on single-nucleotide polymorphisms (SNPs). Conjuga

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KK, Sriram, Tsegaye Sewunet, Walaiporn Wangchinda, et al. "Optical DNA Mapping of Plasmids Reveals Clonal Spread of Carbapenem-Resistant Klebsiella pneumoniae in a Large Thai Hospital." Antibiotics 10, no. 9 (2021): 1029. http://dx.doi.org/10.3390/antibiotics10091029.

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Carbapenem-resistant Klebsiella pneumoniae (CR-KP) in patients admitted to hospitals pose a great challenge to treatment. The genes causing resistance to carbapenems are mostly found in plasmids, mobile genetic elements that can spread easily to other bacterial strains, thus exacerbating the problem. Here, we studied 27 CR-KP isolates collected from different types of samples from 16 patients admitted to the medical ward at Siriraj Hospital in Bangkok, Thailand, using next generation sequencing (NGS) and optical DNA mapping (ODM). The majority of the isolates belonged to sequence type (ST) 16

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ARYAL, Prerit Upadhyaya, Benjamas THAMJARUNGWONG, Kamonnut SINGKHAMANAN, et al. "Emergence of Carbapenem-Resistant Enterobacteriaceae in a Tertiary Care Hospital in Southern Thailand†." Walailak Journal of Science and Technology (WJST) 17, no. 10 (2020): 1139–48. http://dx.doi.org/10.48048/wjst.2020.10729.

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Carbapenem-resistant Enterobacteriaceae (CRE) is emerging as a major problem in healthcare settings globally, including Thailand, due to limited therapeutic options. We reported the detection, antimicrobial susceptibility profiles, and the presence of carbapenemase genes of CRE isolates obtained from Songklanagarind Hospital between July 2012 and June 2015. A total of 273 non-duplicated CRE isolates was recovered from 248 patients. The predominant organism was Klebsiella pneumoniae (183 [67.0 %]), followed by Escherichia coli (38 [13.9 %]). The susceptibility to 13 antibiotics was performed by

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Chua, Jie Yin, Ze Qin Lim, Song Qi Dennis Loy, et al. "Evaluation of the Xpert Carba-R assay for quantifying carbapenemase-producing bacterial load in stool samples." PLOS ONE 19, no. 8 (2024): e0309089. http://dx.doi.org/10.1371/journal.pone.0309089.

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Background The spread of Carbapenemase-producing Organisms (CPO) remains a major threat globally. Within clinical settings, the existing method of determining gene load involves traditional culture to determine bacterial load and polymerase-chain-reaction-based Xpert Carba-R Assay to determine carbapenemase gene type. However, there is a need for a fast and accurate method of quantifying CPO colonisation to study the risk of persistent CPO carriage. Objective This study evaluated the accuracy of Xpert Carba-R Ct value in estimating carbapenamase producing bacterial loads in stool samples. Meth

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Pereira, Hoberdan Oliveira, Marcelo Carneiro, Braulio Roberto Goncalves Marinho Couto, Dhian Renato Almeida Camargo, Carmem Dolores Faria, and Amanda Aparecida Felizardo. "Impact of the COVID-19 pandemic on the distribution and resistance of multidrug-resistant genes in Minas Gerais, Brazil: challenges and implications." International Journal of Clinical Trials 12, no. 3 (2025): 181–86. https://doi.org/10.18203/2349-3259.ijct20252195.

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Background: Following the COVID-19 pandemic, a significant rise in multidrug-resistant pathogens such as Acinetobacter, Enterobacter, Escherichia, Klebsiella, Providencia, Pseudomonas and Serratia spp. was observed in Minas Gerais, Brazil. Diagnostic disparities and antimicrobial overuse for COVID-19-associated pneumonia likely contributed to resistance gene spread. Methods: This retrospective, cross-sectional, descriptive study analysed 13,012 Gram-negative bacterial isolates collected from hospitals across Minas Gerais between 2016 and 2022. Samples, including urine, tracheal secretion, bloo

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Sopirala, Madhuri, Aderonke Badejogbin, Angela Christie-Smith та ін. "Investigation of the First Case of New Delhi Metallo-β-Lactamase-1–Producing Pseudomonas aeruginosa in Texas". Infection Control & Hospital Epidemiology 41, S1 (2020): s307. http://dx.doi.org/10.1017/ice.2020.893.

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Background: New Delhi metallo-β-lactamases impart resistance to carbapenems. Enterobacteriaceae carrying New Delhi metallo-β-lactamases have been reported before. However, only 7 cases of blaNDM-carrying Pseudomonas aeruginosa has been reported from 4 states in the United States as of January 1, 2018, according to the CDC. We describe an epidemiologic investigation of the first reported case of blaNDM-carrying Pseudomonas aeruginosa in Texas and the measures that controlled the spread of the organisms carrying this gene at a 30-bed spinal cord injury unit (SCI) and the acute-care hospital with

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Thịnh, Bùi Đức, Lê Thị Thu Hằng, and Nguyễn Quang Huy. "DEVELOPMENT OF A NOVEL MULTIPLEX PCR ASSAY FOR THE DETECTION OF MOBILE CARBAPENEM, TETRACYCLINE RESISTANCE GENES, AND CLASS 1 INTEGRON IN ENVIRONMENTAL AND CLINICAL SPECIMENS." TNU Journal of Science and Technology 230, no. 06 (2025): 383–90. https://doi.org/10.34238/tnu-jst.12494.

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Sự lan truyền nhanh chóng của vi khuẩn kháng kháng sinh và các gen kháng thuốcđe dọa sức khỏe cộng đồng. Các phương pháp dựa trên phản ứng chuỗi polymerase cho phép phát hiện nhanh vi khuẩn kháng thuốc và các yếu tố di truyền kháng kháng sinh.Nghiên cứu này phát triển một phương pháp phản ứng chuỗi polymerase đa mồi để phát hiện đồng thời các gene: tetM (kháng tetracycline), blaNDM và blaKPC (kháng carbapenem), và intI1 (integron-integrase loại 1). Phương pháp này có độ nhạy và độ đặc hiệu 100% trong việc phát hiện các gene đích, cả riêng lẻ và trong hỗn hợp. Ngưỡng phát hiện của phương pháp đ

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Nguyen, Mai Thi Thanh, Chuong Van Le, Phuong Mai Doan, Chinh Van Nguyen, and Huy Quang Vu. "Phenotypic prevalence of resistance to carbapenems, colistin and genes encoding carbapenemase in Pseudomonas aeruginosa." MedPharmRes 5, no. 1 (2021): 18–22. http://dx.doi.org/10.32895/ump.mpr.5.1.4.

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Introduction: The production of carbapenem enzyme is one of the most frequent mechanisms reported in cabapenem resistant Pseudomonas aeruginosa. Besides, a growing number of mobile colistin resistance (MCR) genes are threatening the renewed interest of colistin as a "last-resort" against carbapenem-resistant pathogens. Therefore, the detection of carbapenem-resistant and colistin-resistant phenotypes as well as preventing transmission of multi-resistant P. aeruginosa strains with genes coding for carbapenemase is extremely necessary. Material and methods: Among 159 P. aeruginosa strains were c

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Xiang, Tianxin, Chuanhui Chen, Jiangxiong Wen, et al. "Resistance of Klebsiella pneumoniae Strains Carrying blaNDM–1 Gene and the Genetic Environment of blaNDM–1." Frontiers in Microbiology 11 (April 30, 2020). http://dx.doi.org/10.3389/fmicb.2020.00700.

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Ding, Liang, Zheng Yang, and Baier Sun. "Understanding blaNDM-1 gene regulation in CRKP infections: toward novel antimicrobial strategies for hospital-acquired pneumonia." Molecular Medicine 30, no. 1 (2024). http://dx.doi.org/10.1186/s10020-024-00794-y.

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Abstract Background The escalating challenge of Carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital-acquired pneumonia (HAP) is closely linked to the blaNDM-1 gene. This study explores the regulatory mechanisms of blaNDM-1 expression and aims to enhance antibacterial tactics to counteract the spread and infection of resistant bacteria. Methods KP and CRKP strains were isolated from HAP patients' blood samples. Transcriptomic sequencing (RNA-seq) identified significant upregulation of blaNDM-1 gene expression in CRKP strains. Bioinformatics analysis revealed blaNDM-1 gene involvement

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Yang, Lang, Hong He, Qichao Chen, et al. "Nosocomial Outbreak of Carbapenemase-Producing Proteus mirabilis With Two Novel Salmonella Genomic Island 1 Variants Carrying Different blaNDM–1 Gene Copies in China." Frontiers in Microbiology 12 (January 13, 2022). http://dx.doi.org/10.3389/fmicb.2021.800938.

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NDM-1-producing multidrug-resistant Proteus mirabilis brings formidable clinical challenges. We report a nosocomial outbreak of carbapenem-resistant P. mirabilis in China. Six P. mirabilis strains collected in the same ward showed close phylogenetic relatedness, indicating clonal expansion. Illumina and MinION sequencing revealed that three isolates harbored a novel Salmonella genomic island 1 carrying a blaNDM–1 gene (SGI1-1NDM), while three other isolates showed elevated carbapenem resistance and carried a similar SGI1 but with two blaNDM–1 gene copies (SGI1-2NDM). Four new single nucleotide

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Zhao, Qiong, Longhua Sha, Zhaomeng Wu, et al. "Evolution of carbapenem resistance in klebsiella pneumoniae and escherichia coli carrying blaNDM−1 gene: imipenem exposure results in sustained resistance memory of strains in vitro." Annals of Clinical Microbiology and Antimicrobials 22, no. 1 (2023). http://dx.doi.org/10.1186/s12941-023-00598-8.

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Abstract Background Antibiotics exert an outstanding selective pressure on bacteria, forcing their chromosomal gene mutations and drug resistance genes to spread. The objective of this study is to evaluate the expression of the New Delhi Metallo-β-Lactamase-1 gene (blaNDM−1) in the clinical isolate (Klebsiella pneumoniae TH-P12158), transformant strains Escherichia coli BL21 (DE3)-blaNDM−1, and Escherichia coli DH5α- blaNDM−1 when exposed to imipenem. Methods β-Lactamase genes (blaSHV, blaTEM−1, blaCTX−M−9, blaIMP, blaNDM−1, blaKPC, blaOXA, blaGES, and blaDHA) from randomly selected carbapenem

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