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Dissertations / Theses on the topic 'Blast-induced traumatic brain injury'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Nyein, Michelle K. (Michelle Kyaw). "Computational modeling of blast-induced traumatic brain injury." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59687.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 105-113).<br>Blast-induced TBI has gained prominence in recent years due to the conflicts in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head; no injury thresholds have been established for blast effects on the head, and even direct transmission of the shock wave to the intracranial cavity is disputed. Still less is known about how personal protective equipment suc

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2

Jason, Amanda Marie. "Facial protective devices for blast-induced traumatic brain injury mitigation." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59676.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 75-77).<br>The purpose of the work in this thesis was to develop a finite element model of a helmet with various additional protective devices and to investigate how the personal protective equipment system affects the mechanical response of a human head subjected to a blast. Finite element models of the helmet with and without faceshields and goggles were developed from geometries of the Advanced Combat Helmet an

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Assari, Soroush. "BLAST-INDUCED CEREBROVASCULAR AND BRAIN INJURY: THE THORACIC MECHANISM." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/480107.

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Mechanical Engineering<br>Ph.D.<br>The focus of this dissertation was the biomechanics of blast-induced traumatic brain injury (bTBI). This study had three specific aims. One of the specific aims was to investigate the thoracic mechanism of bTBI by characterizing the cerebral blood pressure change during local blast exposure to head or chest in a rat model. This model utilized a shock tube to simulate the blast wave. The results showed that there is a blood pressure rise with high amplitude and short duration during both Head-Only and Chest-Only exposure conditions. It was shown that cerebral

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Akin, Faith W., and Owen D. Murnane. "Vestibular Consequences of Mild Traumatic Brain Injury (Blast Injury)." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/1940.

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Yost, Allison L. (Allison Lynne). "Fluid-filled helmet liner concept for protection against blast-induced traumatic brain injury." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/74952.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 122-129).<br>Due to changes in modem warfare threats, as well as advances in body armor, soldier survivability in combat has increased, but blast-induced Traumatic Brain Injury (TBI) has become a prevalent injury in the battlefield. Often referred to as the "signature wound" of the current U.S. conflicts, blast-induced TBI is not a very well understood injury. In an effort to gain more insight on blast mechanisms and TB

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Sarvghad-Moghaddam, Hesam. "Computational Biomechanics of Blast-Induced Traumatic Brain Injury: Role of Loading Directionality, Head Protection, and Blast Flow Mechanics." Diss., North Dakota State University, 2015. http://hdl.handle.net/10365/25381.

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In this dissertation, blast-induced traumatic brain injury (bTBI) is studied with respect to the blast wave directionality, mitigation capability of helmet/faceshield, and blast flow mechanics using finite element (FE) and computational fluid dynamics (CFD) schemes. For the FE study, simulations are performed on a detailed FE head model using LS-DYNA, and CFD simulations are carried out using the ANSYS-CFX to examine the underwash development by analyzing the behavior of blast flow from different directions. The following tasks are conducted. First, the effects of the loading direction

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7

Vechart, Andrew (Andrew Peter). "Design of a composite combat helmet liner for prevention of blast-induced traumatic brain injury." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/64577.

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Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 121-128).<br>Air blast-induced traumatic brain injuries (TBIs) represent a significant percentage of military personnel injuries observed in Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF). Prevalence of blast-induced TBIs is attributed to several factors, including improved body armor, improved diagnostic techniques, greater awareness, and the increased threat of attack by improvised

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Acosta, Glen Howel G. "Susceptibility of parkinson's disease following mild blast traumatic brain injury." Thesis, Purdue University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1571943.

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<p> Blast injury-induced neurotrauma (BINT) is steadily increasing in prevalence due to escalated terror activity and constitutes the signature injury associated with current military conflicts. BINT produces significant neurological deficiencies and there is a growing concern that the injury may produce long-term consequences that affect the resilience and the performance of soldiers. One of the potential consequences is an increased susceptibility to Parkinson's disease (PD). A vital goal aimed at curtailing the post-deployment long-term consequences of blast injury-induced neurotrauma is to

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9

Akin, Faith W. "Vestibular Consequences of Mild Traumatic Brain Injury and Blast Exposure." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2435.

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Akin, Faith W. "Vestibular Consequences of Mild Traumatic Brain Injury and Blast Exposure." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/2429.

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11

Readnower, Ryan Douglas. "TRAUMATIC BRAIN INJURY: CYCLOPHILIN D AS A THERAPEUTIC TARGET AND THE NEUROPATHOLOGY CAUSED BY BLAST." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/823.

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With an estimated incidence of 1.5 million each year, traumatic brain injury (TBI) is a major cause of mortality and morbidity in the United States. Opening of the mitochondrial permeability transition pore (mPTP) is a key event contributing to TBI pathology. Cyclophilin D (CypD), a matrix peptidyl-prolyl cis-trans isomerase, is believed to be the regulating component of the mPTP. Cyclosporin A, an immunosuppressant drug, inhibits CypD and blocks mPTP formation and has been shown to be neuroprotective following TBI. However, it is unclear if CsA’s neuroprotective mechanism is due to inhibition

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12

Rostami, Elham. "Traumatic brain injury in humans and animal models." Doctoral thesis, Stockholm : Reproprint AB, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088.

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13

Akin, Faith W., Owen D. Murnane, Courtney D. Hall, and Kristal M. Riska. "Vestibular Consequences of Mild Traumatic Brain Injury and Blast Exposure: A Review." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/1778.

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The purpose of this article is to review relevant literature on the effect of mild traumatic brain injury (mTBI) and blast injury on the vestibular system. Dizziness and imbalance are common sequelae associated with mTBI, and in some individuals, these symptoms may last for six months or longer. In war-related injuries, mTBI is often associated with blast exposure. The causes of dizziness or imbalance following mTBI and blast injuries have been linked to white matter abnormalities, diffuse axonal injury in the brain, and central and peripheral vestibular system damage. There is some evidence t

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Sukhina, Alona. "Developments on Post-Traumatic Brain Injury-Induced Hypothalamic Pituitary Dysfunction: A Pediatric Case." Thesis, The University of Arizona, 2018. http://hdl.handle.net/10150/626895.

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15

Corwin, Frank. "Characterization of a Blast Wave Device and Blast Wave Induced Traumatic Brain Injury in a Rat Model by Magnetic Resonance Imaging and Spectroscopy." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2403.

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Blast wave induced traumatic brain injury (bTBI) is a modality of injury that has come into prominence at the current time due to the large number of military and civilian personnel who have experienced the localized shock wave produced by explosive devices. The shock wave will travel concentrically outward from the explosive center, being absorbed and transmitted thru soft objects, such as tissue, and reflecting off stationary obstructions. Transmission and absorption in tissues can result in a number of physiological measureable injuries, the most common of which being what is frequently c

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Moore, Leah Kathryn. "Neuronal viability and biochemical alterations after mechanical stretch injury an in vitro model of traumatic brain injury-induced neourodegeneration /." Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04072004-180116/unrestricted/moore%5Fleah%5Fk%5F200312%5Fms.pdf.

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Davis, Laurie Michelle Helene. "THE UNDERLYING MECHANISM(S) OF FASTING INDUCED NEUROPROTECTION AFTER MODERATE TRAUMATIC BRAIN INJURY." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/673.

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Traumatic brain injury (TBI) is becoming a national epidemic, as it accounts for 1.5 million cases each year. This disorder affects primarily the young population and elderly. Currently, there is no treatment for TBI, which means that ~2% of the U.S. population is currently living with prolonged neurological damage and dysfunction. Recently, there have been many studies showing that TBI negatively impacts mitochondrial function. It has been proposed that in order to save the cell from destruction mitochondrial function must be preserved. The ketogenic diet, originally designed to mimic fasting

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Saber, Maha M. "The Effects of TREM2 deficiency on Traumatic Brain Injury- induced Neuroinflammation and Neurodegeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1465648612.

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Daniels, Teresa. "Inhibition of injury-induced cell proliferation in the dentate gyrus impairs cognitive recovery following traumatic brain injury." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2800.

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Traumatic brain injury (TBI) induces a robust cellular proliferative response among neural stem/progenitor cells (NS/NPCs) in the dentate gyrus of the hippocampus. This proliferative effect is thought to contribute to the innate cognitive recovery observed following TBI. Inhibition of hippocampal neurogenesis impairs cognitive function. Furthermore, enhancement of injury-induced hippocampal neurogenesis via intraventricular administration of basic fibroblast growth factor (bFGF) improves cognitive function in animals following TBI. In this experiment, we investigated the direct association bet

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Moore, Leah Kathryn. "Neuronal viability and biochemical alterations after mechanical stretch injury: ban in vitro model of traumatic brain injury-induced neourodegeneration." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5362.

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Wang, Zihui. "Biomineralization: A New Mechanism of Zinc Precipitation-induced Cell and Tissue Injury." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1578055809097929.

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22

Shafieian, Mehdi. "Toward a Universal Constitutive Model for Brain Tissue." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/204511.

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Mechanical Engineering<br>Ph.D.<br>Several efforts have been made in the past half century to characterize the behavior of brain tissue under different modes of loading and deformation rates; however each developed model has been associated with limitations. This dissertation aims at addressing the non-linear and rate dependent behavior of brain tissue specially in high strain rates (above 100 s-1) that represents the loading conditions occurring in blast induced neurotrauma (BINT) and development of a universal constitutive model for brain tissue that describes the tissue mechanical behavior

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Akin, Faith W., and Owen D. Murnane. "Head Injury and Blast Exposure: Vestibular Consequences." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/1786.

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Young adults are more likely to suffer blast injury and traumatic brain injury (TBI) than other age groups. This article reviews the literature on the vestibular consequences of blast exposure and TBI and concussion. In addition, the vestibular test findings obtained from 31 veterans with a history of blast exposure and/or mild TBI are presented. The authors discuss loss of horizontal semicircular canal function and postural instability related to head injury. Preliminary data suggest the novel theory that otolith organs are uniquely vulnerable to head injury and blast exposure.

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Gattu, Ramtilak, Faith W. Akin, Anthony T. Cacace, et al. "Vestibular, Balance, Microvascular and White Matter Neuroimaging Characteristics of Blast Injuries and Mild Traumatic Brain Injury: Four Case Reports." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/542.

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Background: Case reports are presented on four Veterans, aged 29–46 years, who complained of chronic dizziness and/or postural instability following blast exposures. Two of the four individuals were diagnosed with mild traumatic brain injury and three of the four were exposed to multiple blasts. Comprehensive vestibular, balance, gait, audiometry and neuroimaging procedures were used to characterize their injuries.Case report: Vestibular assessment included videonystagmography, rotary chair and cervical and ocular vestibular evoked myogenic potentials. Balance and gait testing included the sen

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Hodges, Cooper Benton. "Heterogenity in Brain Injury: An Investigation of the Efficacy of Qualitative Comparative Analysis in Diffusion Tensor Imaging." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8664.

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Traumatic brain injury (TBI) and its associated neural and cognitive sequelae are of increasing interest in military populations. Blast-related TBI is becoming more commonplace in military Service Members and Veterans since Operation Iraqi Freedom/Operation Enduring Freedom/Operation New Dawn and their following conflicts. It is currently unclear whether blast-related injuries cause unique neural and cognitive deficits. The present investigation, in Study 1, aims to investigate the differences in blast-related and non-blast related TBI using traditional statistical techniques. In Study 2, this

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Kwong, Man Ting. "Computational modelling of mechanically induced electrophysiological alterations of axons and nerve." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:abd9274f-0a17-44c0-a41f-946fa52802b6.

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In the last decade, traumatic brain injuries (TBIs) and spinal cord injuries (SCIs) has become one of the most scrutinised medical challenges of our time. However, the lower quality of life experienced by the sufferer and the associated socio-economic cost of both TBI and SCI remain a huge burden for society. There is currently no reliable way to evaluate the level of functional damage caused by TBI and SCI related mechanical forces without invasive examination. The types of axonopathy involved in such injuries are the combinations of coupled mechanical-electrophysiological phenomena at multip

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Mobley, M. E., Faith W. Akin, Courtney D. Hall, Owen D. Murnane, and Jennifer R. Sears. "Longitudinal consequences of mTBI and blast exposure on vestibular and balance function: preliminary observations." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2461.

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Christie, Lauren. "Factors influencing the implementation and sustainability of upper limb constraint-induced movement therapy (CIMT) programs for people with stroke and traumatic brain injury." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26816.

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Constraint-induced movement therapy (CIMT) is a strongly recommended intervention in the Australian stroke guidelines for post-stroke arm recovery, yet delivery remains poor. The aim of this program of research was to investigate how CIMT can be effectively implemented and sustained in practice. Six studies were conducted. Study 1 was an international cross-sectional survey investigating clinician knowledge and experience of delivering CIMT protocols in neurorehabilitation. Study 2 was a descriptive qualitative study exploring the individual, organisational and social factors enabling imple

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Cullen, Daniel Kacy. "Traumatically-Induced Degeneration and Reactive Astrogliosis in 3-D Neural Co-Cultures: Factors Influencing Neural Stem Cell Survival and Integration." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7584.

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Traumatic brain injury (TBI) results from a physical insult to the head and often results in temporary or permanent brain dysfunction. However, the cellular pathology remains poorly understood and there are currently no clinically effective treatments. The overall goal of this work was to develop and characterize a novel three-dimensional (3-D) in vitro paradigm of neural trauma integrating a robust 3-D neural co-culture system and a well-defined biomechanical input representative of clinical TBI. Specifically, a novel 3-D neuronal-astrocytic co-culture system was characterized, establishin

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Reneer, Dexter V. "BLAST-INDUCED BRAIN INJURY: INFLUENCE OF SHOCKWAVE COMPONENTS." UKnowledge, 2012. http://uknowledge.uky.edu/neurobio_etds/3.

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Blast-induced traumatic brain injury (bTBI) has been described as the defining injury of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF). Previously, most blast injury research has focused on the effects of blast on internal, gas filled organs due to their increased susceptibility. However, due to a change in enemy tactics combined with better armor and front-line medical care, bTBI has become one of the most common injuries due to blast. Though there has been a significant amount of research characterizing the brain injury produced by blast, a sound understanding of the contribution o

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Cho, Hyung Joon. "Pro-oxidative and Pro-inflammatory Mechanisms of Brain Injury in Experimental Animal and 3D Cell Culture Model Systems." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/73476.

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The pro-oxidative and pro-inflammatory mechanisms have been implicated in various human diseases including neurological and psychiatric disorders. However, there is only limited information available on the etiology in the progression of neurological damage to brain. The emergence of tissue engineering with the growing interest in mechanistic studies of brain injury now raises great opportunities to study complex physiological and pathophysiological process in vitro. Therefore, the prime goals of this study include: (1) Determination of the molecular and cellular mechanisms responsible for bla

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Laksari, Kaveh. "Nonlinear Viscoelastic Wave Propagation in Brain Tissue." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/242293.

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Mechanical Engineering<br>Ph.D.<br>A combination of theoretical, numerical, and experimental methods were utilized to determine that shock waves can form in brain tissue from smooth boundary conditions. The conditions that lead to the formation of shock waves were determined. The implication of this finding was that the high gradients of stress and strain that could occur at the shock wave front could contribute to mechanism of brain injury in blast loading conditions. The approach consisted of three major steps. In the first step, a viscoelastic constitutive model of bovine brain tissue under

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Hue, Christopher Donald. "Blood-Brain Barrier Dysfunction and Repair after Blast-Induced Traumatic Brain Injury." Thesis, 2015. https://doi.org/10.7916/D8416W5W.

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Traumatic brain injury (TBI) is the signature injury of modern military conflicts due to widespread use of improvised explosive devices (IEDs) and modern body armor. However, the exact biophysical mechanisms of blast-induced traumatic brain injury (bTBI) and its pathological effects on the blood-brain barrier (BBB) – a structure essential for maintaining brain homeostasis – remain poorly understood. The specific aims of this thesis are to: 1) determine a threshold for primary blast-induced BBB dysfunction in vitro; 2) determine the effect of repeated blast on BBB integrity in vitro; 3) impro

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Vogel, III Edward Weigand. "Pathobiological Mechanisms and Treatment of Electrophysiological Dysfunction Following Primary Blast-Induced Traumatic Brain Injury." Thesis, 2017. https://doi.org/10.7916/D8P273TK.

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Traumatic brain injury (TBI) is the signature injury of the ongoing military conflicts in the Middle East and Afghanistan, largely due to the use of improvised explosive devices (IEDs), which have affected soldiers and civilians alike. Blast-induced TBI (bTBI) biomechanics are complex and multiphasic. While research has clearly demonstrated the negative effects of penetrative (secondary blast) and inertia-driven (tertiary blast) injury, the effect of shock wave loading (primary blast) on the brain remains unclear. Combined primary-tertiary blast exposure in vivo has been reported previously

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Panzer, Matthew Brian. "Numerical Simulation of Primary Blast Brain Injury." Diss., 2012. http://hdl.handle.net/10161/6148.

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<p>Explosions are associated with more than 80% of the casualties in the Iraq and Afghanistan wars. Given the widespread use of thoracic protective armor, the most prevalent injury for combat personnel is blast-related traumatic brain injury (TBI). Almost 20% of veterans returning from duty had one or more clinically confirmed cases of TBI. In the decades of research prior to 2000, neurotrauma was under-recognized as a blast injury and the etiology and pathology of these injuries remains unclear.</p><p>This dissertation used the finite element (FE) method to address many of the biomechanics-ba

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Miller, Danielle. "Behavioral and neural correlates of chronic blast-related mild traumatic brain injury." Thesis, 2016. https://hdl.handle.net/2144/16739.

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Blast-related mild traumatic brain injury (mTBI) is a common injury among Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans due to the frequent use of improvised explosive devices (IEDs). A significant minority of veterans with blast-related mTBI complain of postconcussion symptoms (PCS) and cognitive difficulties, even years after the injury. Studies have suggested that these behavioral sequelae are primarily linked to mental health disorders such as posttraumatic stress disorder (PTSD). However, mTBI is associated with neural changes and the impact of these changes on beh

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(6990368), Marcela Cruz Haces. "Mechanisms of neuropathic pain following mild blast traumatic brain injury and chronic stress." Thesis, 2019.

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The incidence of mild blast traumatic brain injuryhas risen due tothe increased use of improvised explosive devices (IEDs) in militaryconflicts. Mild blast TBI (mbTBI) is especially relevant due to its lack of acutely observable symptoms, and to its association with long-term neurodegenerative and neuropsychiatric disorders. Predominantly, TBI patients often suffer from chronic stress, neuropathic pain and headaches, which greatly compromise the health and quality of life of these individuals. Treatments for neuropathic pain have been empirically found a

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Catudal, Evan. "Mild traumatic brain injury alters pneumonia-induced coagulopathy in mice." Thesis, 2016. https://hdl.handle.net/2144/16778.

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Traumatic brain injury (TBI) is a major cause of death among trauma patients and is associated with a high rate of mortality due to complications such as bacterial pneumonia, sepsis, and subsequent coagulopathies. While severe TBI is positively associated with the development of pneumonia, mild traumatic brain injury (mTBI) results in a paradoxical decrease in mortality following bacterial pneumonia via an unidentified mechanism. New evidence suggests that mTBI stimulates vagus nerve signaling resulting in an anti-inflammatory state that is mediated by neurotransmitters (NT) such as acetylc

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Haladuick, Tyler. "Numerical Simulation of Blast Interaction with the Human Body: Primary Blast Brain Injury Prediction." Thesis, 2014. http://hdl.handle.net/10012/8265.

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In Operations Enduring Freedom and Iraqi Freedom, explosions accounted for 81% of all injuries; this is a higher casualty percentage than in any previous wars. Blast wave overpressure has recently been associated with varying levels of traumatic brain injury in soldiers exposed to blast loading. Presently, the injury mechanism behind primary blast brain injury is not well understood due to the complex interactions between the blast wave and the human body. Despite these limitations in the understanding of head injury thresholds, head kinematics are often used to predict the overall potential f

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DeWalt, Gloria Jessica. "Preliminary investigation of acute recovery and the influence of anesthetics following blast induced traumatic brain injury in C57BL/6 mice." Thesis, 2014. https://hdl.handle.net/2144/14303.

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Recognition of traumatic brain injury (TBI) has increased due to higher rates of injuries reported in sports and veterans. Several animal models exist to study TBI, but one that is particularly relevant in recapitulating combat trauma is blast-induced TBI (bTBI). Ethical considerations have resulted in the use of anesthetics and analgesics in virtually all animal models of TBI. However, emerging evidence indicates that anesthetics may provide neuroprotection that could confound results. Therefore, I am determining the level of anesthetic induced neuroprotection in acute recovery (48 Hours) fo

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Chen, Ciao Ting, and 陳巧婷. "Molecular analysis on traumatic brain injury induced epileptic seizure in zebrafish." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/9a95ds.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>103<br>Epilepsy is a brain disorder that develops spontaneously. Recurring seizures are caused by abnormal neuronal activity in the central nervous system (CNS). The complex etiology of epilepsy is shown to contain multiple causes, including chemical induction, brain injury and genetic factors, which further complicate the analysis. Thus, it is still not possible to predict the occurrence of epileptic seizure due to lack of understanding of its disease mechanism. Previously, we have found the abnormal swimming patterns in traumatic brain injury (TBI) zebrafish r

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Lungwitz, Elizabeth Ann. "Development, validation, and characterization of a novel preclinical animal model of social familiarity-induced anxiolysis." Diss., 2017. http://hdl.handle.net/1805/15184.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Social support is a powerful therapeutic against fear and anxiety and is utilized in many psychotherapies. The concept that a familiar or friendly presence helps a person learn to overcome anxiety has been well-known for decades, yet, the basic neural mechanisms that regulate this psychosocial learning remain unknown. A first step towards elucidating these basic mechanisms is the development of a valid preclinical animal model. However, preclinical behavioral models exploring the use of a social presence in reducing anxiety have not

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Fisher, Andrew. "Modeling acute and chronic effects of blast- and impact-related neurotrauma in mice." Thesis, 2017. https://hdl.handle.net/2144/23571.

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Military-related blast-exposure and sports-related closed-head impact-injury are associated with traumatic brain injury (TBI) and chronic traumatic encephalopathy (CTE), a tau protein neurodegenerative disease. Despite growing awareness of links between TBI and CTE, the mechanisms underpinning this association, and relationship to concussive and subconcussive head injury, are poorly understood. This dissertation addresses the hypothesis that blast-exposure and impact-injury induce traumatic acceleration of the head and injurious forces in the brain that led to structural brain damage (TBI) and

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Brizuela, MDV. "Injury induced plasticity in primary neuronal culture and the mature brain." Thesis, 2017. https://eprints.utas.edu.au/23792/1/Brizuela_whole_thesis.pdf.

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The mature central nervous system (CNS) is unable to fully repair after traumatic brain injury (TBI). Following an injury to the adult brain there is a complex sequence of events that take place across a broad time course. The cellular mechanisms evoked by the brain when attempting to respond to injury need to be fully elucidated in order to devise effective therapeutic interventions. The current thesis is based upon the hypotheses that recovery following trauma will require the activation of reactive and compensatory plasticity and that the mechanisms underlying this plasticity are intrinsica

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Wang, Yi-Wen, and 王怡文. "The mechanisms of interleukin-1 induced neuron death during traumatic brain injury in rats." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/61646662054043811280.

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碩士<br>國立嘉義大學<br>生物科技研究所<br>92<br>Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity and mortality all over the world. It mainly affects young adults in their most productive stage of life and makes an enormous social and economical cost. However, there is no adequate treatment to reduce the cerebral damage following brain injury. This study assessed the effect of IL-1 on TBI-induced neuron damage. TBI model set up by the calibrated weight-drop device (450 g weight, 2 m height) and the rats were divided into sham operation and different time course after TBI (0 hr, 3

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Tsai, Ya-Hsin, and 蔡亞欣. "The role of hippocampal transient receptor potential vanilloid type 4 (TRPV4) channel in traumatic brain injury-induced brain edema." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28664927183899791830.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>99<br>Traumatic brain injury (TBI) is one of the most prevalent causes of mortality and morbidity all over the world and represents an enormous economical and social cost. Our previous studies have evidenced that Na+-K+-2Cl- co-transporter (NKCC) played an important role in TBI-induced brain edema via mitogen-activated protein kinases (MAPK) cascade. Transient receptor potential vanilloid type 4 (TRPV4) channel is suggested to correlate with neurogenic inflammation, pain transmission and osmosis regulation. In this study, we want to investigate the role of hippocam

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Sturzoiu, Tudor. "The effect of induced normothermia on the outcomes of severe traumatic brain injury patients at Boston Medical Center." Thesis, 2015. https://hdl.handle.net/2144/16277.

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The objective of this work was to evaluate the efficacy of an induced normothermia protocol by comparing patient mortality and outcomes in patients treated at Boston Medical Center (BMC) before and after the implementation of the protocol. The controls (regular fever management) and the cases (induced normothermia) were demographically similar, except there were more whites (p = 0.01) in the control group and more of the patients in the control group were transferred to BMC from outside hospitals (p = 0.006), although there was not a higher incidence of death among patients who were transferre

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Park, Eugene. "Cerebellar injury induced by fluid percussion trauma to the forebrain: Characterization and evaluation of a novel model of traumatic brain injury." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=478946&T=F.

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Liao, Chia-Wei, and 廖家巍. "The effects of Ganoderma Microsporum immunomodulatory protein in cellular protection against glutamate-induced neural excitotoxicity and in improvement of cognitive dysfunction after traumatic brain injury." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/42716218581122845909.

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碩士<br>中原大學<br>生物醫學工程研究所<br>104<br>Neuronal injury and degeneration are responsible for various neurological diseases. Adult mammalian central nerve system (CNS) as a difficulty in repairing injuries because it lacks the regenerative power to replace damaged neuronal cells and reconstruct dendritic connections. Neuronal injury release some inflammatory mediators and oxidative stress. Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system, which is important for neural development, synaptic plasticity, and learning and memory. Excessive stimulation of glut

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