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Journal articles on the topic 'Blast-induced traumatic brain injury'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Huang, Jason H., and Richard E. Clatterbuck. "Blast-induced Traumatic Brain Injury." Neurosurgery 62, no. 6 (2008): 1412. http://dx.doi.org/10.1227/01.neu.0000333492.48818.1b.

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2

Nikishin, Vasiliy O., Igor' V. Litvinenko, and Konstantin M. Naumov. "Features of blast-induced traumatic brain injury." Russian Military Medical Academy Reports 42, no. 4 (2023): 451–58. http://dx.doi.org/10.17816/rmmar611153.

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Traumatic brain injury, despite its prevalence and study, is the most urgent issue of medicine in clinical, social and military-medical significance. In Russia, about 500 thousand people receive a traumatic brain injury every year, and the damage to the country’s economy exceeds 500 billion rubles a year. Traumatic brain injury is damage by mechanical energy to the skull and intracranial contents (brain, meninges, vessels, cranial nerves), accompanied by clinical symptoms and, in most cases, morphological changes. Recently, blast-induced traumatic brain injury has acquired particular importanc

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3

Elder, Gregory A., Effie M. Mitsis, Stephen T. Ahlers, and Adrian Cristian. "Blast-induced Mild Traumatic Brain Injury." Psychiatric Clinics of North America 33, no. 4 (2010): 757–81. http://dx.doi.org/10.1016/j.psc.2010.08.001.

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4

Taylor, Paul A., John S. Ludwigsen, and Corey C. Ford. "Investigation of blast-induced traumatic brain injury." Brain Injury 28, no. 7 (2014): 879–95. http://dx.doi.org/10.3109/02699052.2014.888478.

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5

Venkatasubramanian, Palamadai N., Juan C. Pina-Crespo, Kiran Mathews, et al. "Initial Biphasic Fractional Anisotropy Response to Blast-Induced Mild Traumatic Brain Injury in a Mouse Model." Military Medicine 185, Supplement_1 (2020): 243–47. http://dx.doi.org/10.1093/milmed/usz307.

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Abstract Introduction Blast-induced mild traumatic brain injury was generated in a mouse model using a shock tube to investigate recovery and axonal injury from single blast. Methods A supersonic helium wave hit the head of anesthetized male young adult mice with a reflected pressure of 69 psi for 0.2 ms on Day 1. Subsequently, the mice were cardioperfused on Days 2, 5, or 12. The isolated brains were subjected to diffusion tensor imaging. Reduced fractional anisotropy (FA) indicated axonal injury. Results After single blast, FA showed a biphasic response in the corpus callosum with decrease o

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6

Risdall, Jane E., and David K. Menon. "Traumatic brain injury." Philosophical Transactions of the Royal Society B: Biological Sciences 366, no. 1562 (2011): 241–50. http://dx.doi.org/10.1098/rstb.2010.0230.

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There is an increasing incidence of military traumatic brain injury (TBI), and similar injuries are seen in civilians in war zones or terrorist incidents. Indeed, blast-induced mild TBI has been referred to as the signature injury of the conflicts in Iraq and Afghanistan. Assessment involves schemes that are common in civilcian practice but, in common with civilian TBI, takes little account of information available from modern imaging (particularly diffusion tensor magnetic resonance imaging) and emerging biomarkers. The efficient logistics of clinical care delivery in the field may have a rol

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7

Zhao, Yan, and Zheng-Guo Wang. "Blast-induced traumatic brain injury: a new trend of blast injury research." Chinese Journal of Traumatology 18, no. 4 (2015): 201–3. http://dx.doi.org/10.1016/j.cjtee.2015.10.002.

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8

Sawyer, T. W., T. Josey, Y. Wang, et al. "Investigations of primary blast-induced traumatic brain injury." Shock Waves 28, no. 1 (2017): 85–99. http://dx.doi.org/10.1007/s00193-017-0756-2.

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9

Kozlov, S. V., V. D. Mishalov, K. М. Sulojev, and Yu V. Kozlova. "Pathomorphological markers of blast-induced brain injury." Morphologia 15, no. 3 (2021): 96–100. http://dx.doi.org/10.26641/1997-9665.2021.3.96-100.

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Background. Recently, interest in blast-induced brain injuries has been increasing due to military events and the use of explosive devices in eastern Ukraine. Considering the diagnostic uncertainty regarding the specific signs of brain injury after the distant action of an blast shock wave, the danger of prognostic consequences, the increase of the cases of explosive injury number, we consider that selected for study topic is relevant. Objective. Purpose – determination of pathomorphological changes of the brain after the action of the blast wave. Methods. To solving this purpose, a retrospect

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10

Nakagawa, Atsuhiro, and Teiji Tominaga. "Primary Blast-induced Traumatic Brain Injury : Current Understandings and Translational Research(Traumatic Head Injury Update)." Japanese Journal of Neurosurgery 20, no. 12 (2011): 896–902. http://dx.doi.org/10.7887/jcns.20.896.

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11

Kozlova, Yu, and K. Kozlova. "THE IMPACT OF BLAST-INDUSED TRAUMATIC BRAIN INJURY ON PASSIVE AVOIDANCE RESPONSE." Clinical anatomy and operative surgery 21, no. 1 (2022): 15–19. http://dx.doi.org/10.24061/1727-0847.21.1.2022.03.

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Among military personnel participating in armed conﬂ icts around the world, blast- induced traumatic brain injury is common. Mild blast- induced traumatic brain injury is characterized by clinical signs in the form of impaired cognitive functions, including memory. In this regard, the objective is to study the features of the inﬂ uence of an blast-i nduced traumatic brain injury on conditioned reﬂ ex activity in the experiment. The studies were carried out on 18 white male Wistar rats aged 5-7 months, weighing 180.0-220.0 g, which were kept under standard vivarium conditions of Dnipro State Me

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12

Rosenfeld, Jeffrey V., Alexander C. McFarlane, Peter Bragge, Rocco A. Armonda, Jamie B. Grimes, and Geoffrey S. Ling. "Blast-related traumatic brain injury." Lancet Neurology 12, no. 9 (2013): 882–93. http://dx.doi.org/10.1016/s1474-4422(13)70161-3.

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13

Moore, David F., and Michael S. Jaffee. "Blast associated traumatic brain injury." Journal of the Acoustical Society of America 127, no. 3 (2010): 1788. http://dx.doi.org/10.1121/1.3383965.

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14

Bryden, Daniel W., Jessica I. Tilghman, and Sidney R. Hinds. "Blast-Related Traumatic Brain Injury: Current Concepts and Research Considerations." Journal of Experimental Neuroscience 13 (January 2019): 117906951987221. http://dx.doi.org/10.1177/1179069519872213.

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Traumatic brain injury (TBI) is a well-known consequence of participation in activities such as military combat or collision sports. But the wide variability in eliciting circumstances and injury severities makes the study of TBI as a uniform disease state impossible. Military Service members are under additional, unique threats such as exposure to explosive blast and its unique effects on the body. This review is aimed toward TBI researchers, as it covers important concepts and considerations for studying blast-induced head trauma. These include the comparability of blast-induced head trauma

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15

Chen, Yung Chia, Douglas H. Smith, and David F. Meaney. "In-VitroApproaches for Studying Blast-Induced Traumatic Brain Injury." Journal of Neurotrauma 26, no. 6 (2009): 861–76. http://dx.doi.org/10.1089/neu.2008.0645.

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16

Nakagawa, A., K. Ohtani, R. Armonda, et al. "Primary blast-induced traumatic brain injury: lessons from lithotripsy." Shock Waves 27, no. 6 (2017): 863–78. http://dx.doi.org/10.1007/s00193-017-0753-5.

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17

Gu, Ming, Usmah Kawoos, Richard McCarron, and Mikulas Chavko. "Protection against Blast-Induced Traumatic Brain Injury by Increase in Brain Volume." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2075463.

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Blast-induced traumatic brain injury (bTBI) is a leading cause of injuries in recent military conflicts and it is responsible for an increased number of civilian casualties by terrorist attacks. bTBI includes a variety of neuropathological changes depending on the intensity of blast overpressure (BOP) such as brain edema, neuronal degeneration, diffuse axonal damage, and vascular dysfunction with neurological manifestations of psychological and cognitive abnormalities. Internal jugular vein (IJV) compression is known to reduce intracranial compliance by causing an increase in brain volume and

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18

Kozlova, Yu.V., H.S. Maslak, O.E. Abraimova, V.V. Koldunov, and O.E. Khudyakov. "State of spatial memory and antioxidant system activity of rats in the dynamics of development of blast-induced traumatic brain injury." Medicni perspektivi 27, no. 3 (2022): 27–32. https://doi.org/10.26641/2307-0404.2022.3.265769.

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The main purpose of this study was to investigate the changes in spatial memory and catalase activity in dynamics in the blast-induced traumatic brain injury (bTBI). The experiment was carried out on 67 albino male Wistar rats, which were randomly divided into three groups: I group – experimental (n=34), animals were subjected to inhalation anesthesia with halothane, fixed and was simulated blast-induced traumatic brain injury was simulated by generating a shock wave with an overpressure of 26.4±3.6 kPa, II group – sham (n=34), animals which were subjected only to inhal

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19

Venkatasubramanian, Palamadai N., Prachi Keni, Roland Gastfield, et al. "Diffusion Tensor Imaging Detects Acute and Subacute Changes in Corpus Callosum in Blast-Induced Traumatic Brain Injury." ASN Neuro 12 (January 2020): 175909142092292. http://dx.doi.org/10.1177/1759091420922929.

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There is a critical need for understanding the progression of neuropathology in blast-induced traumatic brain injury using valid animal models to develop diagnostic approaches. In the present study, we used diffusion imaging and magnetic resonance (MR) morphometry to characterize axonal injury in white matter structures of the rat brain following a blast applied via blast tube to one side of the brain. Diffusion tensor imaging was performed on acute and subacute phases of pathology from which fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were calculated for

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20

Hua, Yi, Shengmao Lin, and Linxia Gu. "Relevance of Blood Vessel Networks in Blast-Induced Traumatic Brain Injury." Computational and Mathematical Methods in Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/928236.

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Cerebral vasculature is a complex network that circulates blood through the brain. However, the role of this networking effect in brain dynamics has seldom been inspected. This work is to study the effects of blood vessel networks on dynamic responses of the brain under blast loading. Voronoi tessellations were implemented to represent the network of blood vessels in the brain. The brain dynamics in terms of maximum principal strain (MPS), shear strain (SS), and intracranial pressure (ICP) were monitored and compared. Results show that blood vessel networks significantly affected brain respons

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21

Moore, David F., and Michael S. Jaffee. "Military traumatic brain injury and blast." NeuroRehabilitation 26, no. 3 (2010): 179–81. http://dx.doi.org/10.3233/nre-2010-0553.

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22

Kamnaksh, Alaa, Erzsebet Kovesdi, Sook-Kyung Kwon, et al. "Factors Affecting Blast Traumatic Brain Injury." Journal of Neurotrauma 28, no. 10 (2011): 2145–53. http://dx.doi.org/10.1089/neu.2011.1983.

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23

Weppner, Justin, Mark Linsenmeyer, and William Ide. "Military Blast-Related Traumatic Brain Injury." Current Physical Medicine and Rehabilitation Reports 7, no. 4 (2019): 323–32. http://dx.doi.org/10.1007/s40141-019-00241-8.

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24

Magone, M. Teresa, Ellen Kwon, and Soo Y. Shin. "Chronic visual dysfunction after blast-induced mild traumatic brain injury." Journal of Rehabilitation Research and Development 51, no. 1 (2014): 71–80. http://dx.doi.org/10.1682/jrrd.2013.01.0008.

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25

Kawoos, Usmah, Xu Meng, Shi-Min Huang, Arye Rosen, Richard M. McCarron, and Mikulas Chavko. "Telemetric Intracranial Pressure Monitoring in Blast-Induced Traumatic Brain Injury." IEEE Transactions on Biomedical Engineering 61, no. 3 (2014): 841–47. http://dx.doi.org/10.1109/tbme.2013.2291239.

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26

Wang, Hongxing, Yi Ping Zhang, Jun Cai, et al. "A Compact Blast-Induced Traumatic Brain Injury Model in Mice." Journal of Neuropathology & Experimental Neurology 75, no. 2 (2016): 183–96. http://dx.doi.org/10.1093/jnen/nlv019.

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27

Kucherov, Yan, Graham K. Hubler, and Ralph G. DePalma. "Blast induced mild traumatic brain injury/concussion: A physical analysis." Journal of Applied Physics 112, no. 10 (2012): 104701. http://dx.doi.org/10.1063/1.4765727.

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28

Adams, Sherry, Jillian A. Condrey, Hsiu-Wen Tsai, Stanislav I. Svetlov, and Paul W. Davenport. "Respiratory responses following blast-induced traumatic brain injury in rats." Respiratory Physiology & Neurobiology 204 (December 2014): 112–19. http://dx.doi.org/10.1016/j.resp.2014.08.015.

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29

Li, Bing Cang, Yue Li, Chuan Xu, et al. "Blast-induced traumatic brain injury of goats in confined space." Neurological Research 36, no. 11 (2014): 974–82. http://dx.doi.org/10.1179/1743132813y.0000000314.

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30

Rubovitch, Vardit, Meital Ten-Bosch, Ofer Zohar, et al. "A mouse model of blast-induced mild traumatic brain injury." Experimental Neurology 232, no. 2 (2011): 280–89. http://dx.doi.org/10.1016/j.expneurol.2011.09.018.

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31

Teland, Jan Arild, Fredrik Arrhén, Anders Hamberger, et al. "Numerical simulation of mechanisms of blast‐induced traumatic brain injury." Journal of the Acoustical Society of America 127, no. 3 (2010): 1790. http://dx.doi.org/10.1121/1.3383972.

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32

Petel, O. E., and S. Ouellet. "Experimental models and investigations of blast-induced traumatic brain injury." Shock Waves 28, no. 1 (2018): 1–3. http://dx.doi.org/10.1007/s00193-017-0794-9.

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33

Navarro, Victor M., Nickolas Boehme, Edward A. Wasserman, and Matthew M. Harper. "Enhanced attention in rats following blast-induced traumatic brain injury." Heliyon 10, no. 4 (2024): e25661. http://dx.doi.org/10.1016/j.heliyon.2024.e25661.

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34

Pham, Nam, Thomas W. Sawyer, Yushan Wang, Ferdous Rastgar Jazii, Cory Vair, and Changiz Taghibiglou. "Primary Blast-Induced Traumatic Brain Injury in Rats Leads to Increased Prion Protein in Plasma: A Potential Biomarker for Blast-Induced Traumatic Brain Injury." Journal of Neurotrauma 32, no. 1 (2015): 58–65. http://dx.doi.org/10.1089/neu.2014.3471.

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35

Cernak, Ibolja, and Linda J. Noble-Haeusslein. "Traumatic Brain Injury: An Overview of Pathobiology with Emphasis on Military Populations." Journal of Cerebral Blood Flow & Metabolism 30, no. 2 (2009): 255–66. http://dx.doi.org/10.1038/jcbfm.2009.203.

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This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT). The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental models mimicking features seen in the civilian population. These brain injuries are characterized by primary damage to both gray and white matter and subsequent evolution of secondary pathogenic events at the cellular, biochemical, and molecular levels, which collectively mediate widespread neurodegeneration. An emerging field of research addresses brain injuries related to the military, in particular blast-induced

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36

Kozlova, Yu V. "EXPLORATORY ACTIVITY OF RATS IN THE ACUTE PERIOD OF MILD BLAST-INDUCED TRAUMATIC BRAIN INJURY." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 1 (2024): 89–93. http://dx.doi.org/10.31718/2077-1096.24.1.89.

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The relevance of this work is related to the widespread use of explosive devices in military conflicts. More common and "invisible" is mild blast-induced brain injury. This can manifest through anxiety, emotional dysregulation, and spatial memory impairments. However, significant variability exists in modeling blast-induced traumatic brain injury and spatial memory assessment methods. This study aimed to investigate the exploratory activity of rats during the acute phase of mild blast-induced traumatic brain injury modelled by using a newly developed device. The study carried out on 18 s

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37

Magone, M. Teresa, Glenn C. Cockerham, and Soo Y. Shin. "Visual Dysfunction in Combat-related Mild Traumatic Brain Injury—A Review." US Neurology 09, no. 01 (2013): 61. http://dx.doi.org/10.17925/usn.2013.09.01.61.

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Approximately half of all military personnel who have served in the conflicts in Iraq and Afghanistan are reported to have some degree of combat-related mild traumatic brain injury (TBI). Although in civilian concussion injuries symptoms typically resolve within several weeks, blast-induced mild TBI may be accompanied by prolonged symptoms and afferent and efferent visual dysfunction. Most commonly near vision problems and photophobia are the presenting symptoms. A complete eye exam including vision testing, oculomotor function, and near tasking, is highly recommended after blast-induced mild

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38

Magone, M. Teresa, Glenn C. Cockerham, and Soo Y. Shin. "Visual Dysfunction in Combat Related Mild Traumatic Brain Injury: A Review." US Ophthalmic Review 06, no. 01 (2013): 48. http://dx.doi.org/10.17925/usor.2013.06.01.48.

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Approximately half of all military personnel who have served in the conflicts in Iraq and Afghanistan are reported to have some degree of combat related mild traumatic brain injury (TBI). Although in civilian concussion injuries symptoms typically resolve within several weeks, blast induced mild TBI may be accompanied by prolonged symptoms and afferent and efferent visual dysfunction. Most commonly near vision problems and photophobia are the presenting symptoms. A complete eye exam including vision testing, oculomotor function, and near tasking, is highly recommended after blast induced mild

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39

Kasper, Christine E. "Traumatic Brain Injury Research in Military Populations." Annual Review of Nursing Research 33, no. 1 (2015): 13–29. http://dx.doi.org/10.1891/0739-6686.33.13.

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Traumatic brain injury (TBI) in all of its forms—blast, concussive, and penetrating—has been an unfortunate sequela of warfare since ancient times. The continued evolution of military munitions and armor on the battlefield, as well as the insurgent use of improvised explosive devices, has led to blast-related TBI whose long-term effects on behavior and cognition are not yet known. Advances in medical care have greatly increased survival from these types of injuries. Therefore, an understanding of the potential health effects of TBI is essential. This review focuses on specific aspects of milit

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40

Elder, Gregory A., Miguel A. Gama Sosa, Rita De Gasperi, et al. "The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma." International Journal of Molecular Sciences 25, no. 2 (2024): 1150. http://dx.doi.org/10.3390/ijms25021150.

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Blast-induced neurotrauma has received much attention over the past decade. Vascular injury occurs early following blast exposure. Indeed, in animal models that approximate human mild traumatic brain injury or subclinical blast exposure, vascular pathology can occur in the presence of a normal neuropil, suggesting that the vasculature is particularly vulnerable. Brain endothelial cells and their supporting glial and neuronal elements constitute a neurovascular unit (NVU). Blast injury disrupts gliovascular and neurovascular connections in addition to damaging endothelial cells, basal laminae,

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41

Wermer, Anna, Joseph Kerwin, Kelsea Welsh, Ricardo Mejia-Alvarez, Michaelann Tartis, and Adam Willis. "Materials Characterization of Cranial Simulants for Blast-Induced Traumatic Brain Injury." Military Medicine 185, Supplement_1 (2020): 205–13. http://dx.doi.org/10.1093/milmed/usz228.

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ABSTRACT Introduction The mechanical response of brain tissue to high-speed forces in the blast and blunt traumatic brain injury is poorly understood. Object-to-object variation and interspecies differences are current limitations in animal and cadaver studies conducted to study damage mechanisms. Biofidelic and transparent tissue simulants allow the use of high-speed optical diagnostics during a blast event, making it possible to observe deformations and damage patterns for comparison to observed injuries seen post-mortem in traumatic brain injury victims. Methods Material properties of sever

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42

Guilhaume-Correa, Fernanda, Alicia M. Pickrell, and Pamela J. VandeVord. "The Imbalance of Astrocytic Mitochondrial Dynamics Following Blast-Induced Traumatic Brain Injury." Biomedicines 11, no. 2 (2023): 329. http://dx.doi.org/10.3390/biomedicines11020329.

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Mild blast-induced traumatic brain injury (bTBI) is a modality of injury that has been of major concern considering a large number of military personnel exposed to explosive blast waves. bTBI results from the propagation of high-pressure static blast forces and their subsequent energy transmission within brain tissue. Exposure to this overpressure energy causes a diffuse injury that leads to acute cell damage and, if chronic, leads to detrimental long-term cognitive deficits. The literature presents a neuro-centric approach to the role of mitochondria dynamics dysfunction in bTBI, and changes

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43

Wenchao, Zhang, Qin Bin, He Liang, and Wu Yang. "The Protective Capability of Helmet Against Blast Wave to Prevent Traumatic Brain Injury." Journal of Physics: Conference Series 2891, no. 6 (2024): 062022. https://doi.org/10.1088/1742-6596/2891/6/062022.

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Abstract Blast-induced traumatic brain injury (b-TBI) is a kind of prevalent military injury in combat casualty care, yet little is known about the protective capability of typical helmet structure against blast wave. In this study, a head model under blast was used for experimentally and numerically research. A finite element model with a typical human head structure was established. Tests on the distribution of air pressure field of the unprotected head, typical combat helmet protected head, combat helmet protected head with face shield, motorcycle helmet protected head were carried out afte

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44

Race, Nicholas S., Katharine D. Andrews, Elizabeth A. Lungwitz, et al. "Psychosocial impairment following mild blast-induced traumatic brain injury in rats." Behavioural Brain Research 412 (August 2021): 113405. http://dx.doi.org/10.1016/j.bbr.2021.113405.

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45

Uddin, Olivia, Paige E. Studlack, Saitu Parihar, et al. "Chronic pain after blast-induced traumatic brain injury in awake rats." Neurobiology of Pain 6 (August 2019): 100030. http://dx.doi.org/10.1016/j.ynpai.2019.100030.

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46

Bogdanova, Yelena, and Mieke Verfaellie. "Cognitive Sequelae of Blast-Induced Traumatic Brain Injury: Recovery and Rehabilitation." Neuropsychology Review 22, no. 1 (2012): 4–20. http://dx.doi.org/10.1007/s11065-012-9192-3.

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47

Moss, William C., and Michael J. King. "Blast‐induced traumatic brain injury research at Lawrence Livermore National Laboratory." Journal of the Acoustical Society of America 127, no. 3 (2010): 1789. http://dx.doi.org/10.1121/1.3383970.

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48

Fan, Kaihua, Jie Ma, Wenjing Xiao, et al. "Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome." Chemico-Biological Interactions 271 (June 2017): 15–23. http://dx.doi.org/10.1016/j.cbi.2017.04.021.

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49

Vakhtin, Andrei A., Vince D. Calhoun, Rex E. Jung, Jillian L. Prestopnik, Paul A. Taylor, and Corey C. Ford. "Changes in intrinsic functional brain networks following blast-induced mild traumatic brain injury." Brain Injury 27, no. 11 (2013): 1304–10. http://dx.doi.org/10.3109/02699052.2013.823561.

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50

Lucke-Wold, Brandon P., Aric F. Logsdon, Kelly E. Smith, et al. "Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury." Molecular Neurobiology 52, no. 3 (2014): 1119–34. http://dx.doi.org/10.1007/s12035-014-8902-7.

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