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Journal articles on the topic 'BLAST'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Anwar, Mahdalena Anwar, Siti Nurjanah Nurjanah, and Winiati P. Rahayu. "Aplikasi Basic Local Alignment Search Tool (BLAST) NCBI Pada Penelitian Molekuler Salmonella SPP." Syntax Literate ; Jurnal Ilmiah Indonesia 7, no. 11 (2022): 15446. http://dx.doi.org/10.36418/syntax-literate.v7i11.9037.

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Basic Local Alignment Search Tool (BLAST) merupakan tool pada website NCBI yang banyak digunakan pada penelitian mikrobiologi molekuler. Tujuan penelitian ini adalah melakukan review sistematik dari fungsi program BLAST dan menentukan parameter penting yang diaplikasikan pada penelitian Salmonella asal produk pangan. Salmonella spp. menjadi fokus karena bakteri ini terdiri dari banyak serovar yang memiliki variasi dalam mekanisme virulensi, perbedaan patogenitas dan adaptasi Salmonella terhadap inangnya. Pencarian artikel dilakukan dengan menggunakan mesin pencari PUBMED dan Google Scholar, de

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Smith, Kyle D., Tao Chen, and Rong Z. Gan. "Hearing Damage Induced by Blast Overpressure at Mild TBI Level in a Chinchilla Model." Military Medicine 185, Supplement_1 (2020): 248–55. http://dx.doi.org/10.1093/milmed/usz309.

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Abstract Introduction The peripheral auditory system and various structures within the central auditory system are vulnerable to blast injuries, and even blast overpressure is at relatively mild traumatic brain injury (TBI) level. However, the extent of hearing loss in relation to blast number and time course of post-blast is not well understood. This study reports the progressive hearing damage measured in chinchillas after multiple blast exposures at mild TBI levels (103–138 kPa or 15–20 psi). Materials and Methods Sixteen animals (two controls) were exposed to two blasts and three blasts, r

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Smith, Albert T. "Discrimination of explosions from simultaneous mining blasts." Bulletin of the Seismological Society of America 83, no. 1 (1993): 160–79. http://dx.doi.org/10.1785/bssa0830010160.

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Abstract Large mining blasts can complicate the identification and discrimination of small underground nuclear explosions and may offer evasion opportunities. Mining blasts typically show a unique spectral signature: spectral reinforcements associated with time-delayed detonations between adjacent shot holes or rows of shots. Discrimination of a nuclear detonation that is simultaneous with a mining blast must depend upon recognizing significant spectral or waveform abnormalities within seismic signals from the mining blasts. In this investigation, large, simultaneous detonations within mining

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Taiwo, Blessing Olamide, Yewuhalashet Fissha, Thomas Palangio, et al. "Assessment of Charge Initiation Techniques Effect on Blast Fragmentation and Environmental Safety: An Application of WipFrag Software." Mining 3, no. 3 (2023): 532–51. http://dx.doi.org/10.3390/mining3030030.

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Blast charge initiation procedures have a significant impact on both mining safety and production rates. In this study, the inventory benefit of an electric initiation system was investigated to assess its influence on both fragmentation and blast-induced damages. The WipFrag software was used to examine the size distribution and productivity of 12 small-scale blasts initiated by both nonelectric and electric detonators. All blast rounds were initiated with plain-type electric and NONEL detonators. The average burden, spacing, stemming length, and charge weight were, respectively, 0.85 m, 1.10

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Morley, Michael G., Jackie K. Nguyen, Jeffrey S. Heier, Bradford J. Shingleton, Joseph F. Pasternak, and Kraig S. Bower. "Blast Eye Injuries: A Review for First Responders." Disaster Medicine and Public Health Preparedness 4, no. 2 (2010): 154–60. http://dx.doi.org/10.1001/dmp.v4n2.hra10003.

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ABSTRACTAs the rate of terrorism increases, it is important for health care providers to become familiar with the management of injuries inflicted by blasts and explosions. This article reviews the ocular injuries associated with explosive blasts, providing basic concepts with which to approach the blast-injured patient with eye trauma. We conducted a literature review of relevant articles indexed in PubMed between 1948 and 2007. Two hundred forty-four articles were reviewed. We concluded that ocular injury is a frequent cause of morbidity in blast victims, occurring in up to 28% of blast surv

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Nara, N., and E. A. McCulloch. "Membranes replace irradiated blast cells as growth requirement for leukemic blast progenitors in suspension culture." Journal of Experimental Medicine 162, no. 5 (1985): 1435–43. http://dx.doi.org/10.1084/jem.162.5.1435.

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The blast cells of acute myeloblastic leukemia (AML) may be considered as a renewal population, maintained by blast stem cells capable of both self-renewal and the generation of progeny with reduced or absent proliferative potential. Blast progenitor renewal is manifested in suspension culture by an exponential increase in clonogenic cells. This growth requires that two conditions be met: first, the cultures must contain growth factors in media conditioned either by phytohemagglutinin (PHA)-stimulated mononuclear leukocytes (PHA-LCM), or by cells of the continuous bladder carcinoma line HTB9 (

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Tan, X. Gary, and Peter Matic. "Simulation of Cumulative Exposure Statistics for Blast Pressure Transmission Into the Brain." Military Medicine 185, Supplement_1 (2020): 214–26. http://dx.doi.org/10.1093/milmed/usz308.

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Abstract Introduction This study develops and demonstrates an analysis approach to understand the statistics of cumulative pressure exposure of the brain to repetitive blasts events. Materials and Methods A finite element model of blast loading on the head was used for brain model biomechanical responses. The cumulative pressure exposure fraction (CPEF), ranging from 0.0 to 1.0, was used to characterize the extent and repetition of high pressures. Monte Carlo simulations were performed to generate repetitive blast cumulative exposures. Results The blast orientation effect is as influential as

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Fields, David M., Nils Olav Handegard, John Dalen, et al. "Airgun blasts used in marine seismic surveys have limited effects on mortality, and no sublethal effects on behaviour or gene expression, in the copepod Calanus finmarchicus." ICES Journal of Marine Science 76, no. 7 (2019): 2033–44. http://dx.doi.org/10.1093/icesjms/fsz126.

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Abstract Seismic surveys use airguns that emit low frequency high magnitude sound to detect subsea resources and to map seabed geology. The effect of seismic blasts on Calanus spp., a key food source for commercially important fish, was assessed in field experiments. Immediate mortality of copepods was significantly different from controls at distances of 5 m or less from the airguns. Mortality 1 week after the airgun blast was significantly higher—by 9% relative to controls—in the copepods placed 10 m from the airgun blast but was not significantly different from the controls at a distance of

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Jiang, Shangyuan, Sarah Sanders, and Rong Z. Gan. "Mitigation of Hearing Damage With Liraglutide Treatment in Chinchillas After Repeated Blast Exposures at Mild-TBI." Military Medicine 188, Supplement_6 (2023): 553–60. http://dx.doi.org/10.1093/milmed/usad235.

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ABSTRACT Introduction Although hearing protection devices (HPDs) have been widely used during training and combat, over one million veterans experience service-connected hearing loss. Hearing damage has been reported to be associated with blast-induced mild traumatic brain injury (mTBI) and there is a lack of understanding and treatment. Liraglutide is a glucagon-like peptide-1 receptor agonist and a potential treatment for TBI-induced memory deficits. This study aims to investigate the function of the liraglutide to prevent damage and facilitate hearing restoration in chinchillas exposed to m

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Iacono, Diego, Erin K. Murphy, Cheryl D. Stimpson, Fabio Leonessa, and Daniel P. Perl. "Double Blast Wave Primary Effect on Synaptic, Glymphatic, Myelin, Neuronal and Neurovascular Markers." Brain Sciences 13, no. 2 (2023): 286. http://dx.doi.org/10.3390/brainsci13020286.

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Explosive blasts are associated with neurological consequences as a result of blast waves impact on the brain. Yet, the neuropathologic and molecular consequences due to blast waves vs. blunt-TBI are not fully understood. An explosive-driven blast-generating system was used to reproduce blast wave exposure and examine pathological and molecular changes generated by primary wave effects of blast exposure. We assessed if pre- and post-synaptic (synaptophysin, PSD-95, spinophilin, GAP-43), neuronal (NF-L), glymphatic (LYVE1, podoplanin), myelin (MBP), neurovascular (AQP4, S100β, PDGF) and genomic

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Debnath, Jhuma, Ajay Kumar, and Hrishikesh Sharma. "Numerical investigation of Reinforced-concrete beam-column joints under contact and close-in blast application." Proceedings of the 12th Structural Engineering Convention, SEC 2022: Themes 1-2 1, no. 1 (2022): 1203–8. http://dx.doi.org/10.38208/acp.v1.641.

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The behavior of the concrete and the steel material under blast loads are different. They have different mode of failures under blast loads. Also, responses differ according to the blast types concerning the proximity of the charge kept. It causes different failure modes in the structural members. Close-in or contact blast causes the spallation of concrete. In the near-field blasts, it causes bending failure in the structural members. The behavior of the mode of failure of various joint types subjected to contact-blast and close-in blast loads are numerically studied here. Three different join

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Ha, K., MH Freedman, A. Hrincu, D. Petsche, A. Poon, and EW Gelfand. "Separation of lymphoid and myeloid blasts in the mixed blast crisis of chronic myelogenous leukemia: no evidence for Ig gene rearrangement in CALLA-positive blasts." Blood 66, no. 6 (1985): 1404–8. http://dx.doi.org/10.1182/blood.v66.6.1404.1404.

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Abstract Recent studies suggest that lymphoid blast crisis cells of chronic myelogenous leukemia (CML) expressing the common acute lymphoblastic leukemia antigen (CALLA) are B precursor cells, based on the demonstration of immunoglobulin (Ig) gene rearrangement similar to common acute lymphocytic leukemia. There is little evidence to suggest whether the cells with similar lymphoid characteristics in the mixed blast crisis of CML are also committed to B cell lineage. A patient in “mixed” blast crisis of CML was studied. On the basis of morphology, cytochemistry, and immunological studies, the b

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Ha, K., MH Freedman, A. Hrincu, D. Petsche, A. Poon, and EW Gelfand. "Separation of lymphoid and myeloid blasts in the mixed blast crisis of chronic myelogenous leukemia: no evidence for Ig gene rearrangement in CALLA-positive blasts." Blood 66, no. 6 (1985): 1404–8. http://dx.doi.org/10.1182/blood.v66.6.1404.bloodjournal6661404.

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Recent studies suggest that lymphoid blast crisis cells of chronic myelogenous leukemia (CML) expressing the common acute lymphoblastic leukemia antigen (CALLA) are B precursor cells, based on the demonstration of immunoglobulin (Ig) gene rearrangement similar to common acute lymphocytic leukemia. There is little evidence to suggest whether the cells with similar lymphoid characteristics in the mixed blast crisis of CML are also committed to B cell lineage. A patient in “mixed” blast crisis of CML was studied. On the basis of morphology, cytochemistry, and immunological studies, the blasts wer

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Ahmad, Shahab, Shayan Zeb, Yonghui Wang, and Muhammad Umair. "Blast Performance of Multi-Layer Composite Door Panel with Energy Absorption Connectors." Buildings 15, no. 12 (2025): 2073. https://doi.org/10.3390/buildings15122073.

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Doors are considered vulnerable to failure in structures when subjected to extreme loads, such as blasts. Consequently, blast-resistant doors are designed to withstand blast pressure in important structures. This study developed a multi-layer Steel, Aluminum Foam, and Steel–Concrete–Steel composite door panel with Energy Absorption Connectors (SAFSCS-EACs) under near and far field blast loading using finite element analysis in LS-DYNA. Three dynamic response modes were observed based on the crushing strength of energy absorption connectors (EACs) for the SAFSCS-EAC composite door under both ne

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Shang, Helen, Claire Daniel, Michael J. Maranzano, et al. "Reconsidering the Significance of Blast Cut-Offs in Differentiating between MDS and AML Biology." Blood 142, Supplement 1 (2023): 1884. http://dx.doi.org/10.1182/blood-2023-189790.

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Background The diagnosis of and distinction between acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) have long been based on blast counts, with the presence of ≥20% myeloblasts in marrow or peripheral blood required to define AML in World Health Organization classification. Until 2001, blast counts greater than 30% had been used to diagnose AML by the original French-American-British classification system. However, the 2022 International Consensus Classification proposed a new combined category of MDS/AML with 10-19% blasts. Here we report the real-world treatment patt

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Sainoki, Atsushi, and Hani S. Mitri. "Numerical simulation of rock mass vibrations induced by nearby production blast." Canadian Geotechnical Journal 51, no. 11 (2014): 1253–62. http://dx.doi.org/10.1139/cgj-2013-0480.

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It is of importance to understand the effect of production blasts on the surrounding rock formations in underground mines. This study presents a numerical procedure to simulate stress waves resulting from nearby production blasts. First, the damping coefficient and peak borehole pressure are calibrated using a dynamic numerical model of a single blast hole. The resulting time-varying particle velocities in the surrounding rock mass at the specified points are calculated. These are then used as input parameters in a three-dimensional mine-wide model, considering a positional relationship betwee

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Race, Nicholas, Jesyin Lai, Riyi Shi, and Edward L. Bartlett. "Differences in postinjury auditory system pathophysiology after mild blast and nonblast acute acoustic trauma." Journal of Neurophysiology 118, no. 2 (2017): 782–99. http://dx.doi.org/10.1152/jn.00710.2016.

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Blasts exposures often produce hearing difficulties. Although cochlear damage typically occurs, the downstream effects on central auditory processing are less clear. Moreover, outcomes were compared between individuals exposed to the blast pressure wave vs. those who experienced the blast noise without the pressure wave. It was found that a single blast exposure produced changes at all stages of the ascending auditory path at least 4 wk postblast, whereas blast noise alone produced largely transient changes.

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Singh, Rakesh Kumar, Chhangte Sawmliana, and Panchanan Hembram. "Damage threat to sensitive structures of a thermal power plant from hard rock blasting operations in track hopper area: A case study." International Journal of Protective Structures 11, no. 1 (2019): 3–22. http://dx.doi.org/10.1177/2041419619843633.

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The article deals with the development of controlled blast design patterns and methodologies for excavation of hard rock for foundation work of a track hopper in a running thermal power plant in close proximity of many sensitive structures. Test blasts were conducted with different blast geometries and charge loading patterns at selected locations. The results of the test blasts were analysed to evolve safe controlled blast design patterns and methodologies for completing the total excavation work. The threshold value of vibration for the safety of various structures/foundations present has be

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Westfall, Danielle E., Ling Zhang, Sophie Song, and Stephen Lee. "Concurrent Megakaryocytic and Erythroid Chronic Myelogenous Leukemia Blast Crisis." Archives of Pathology & Laboratory Medicine 132, no. 6 (2008): 1021–25. http://dx.doi.org/10.5858/2008-132-1021-cmaecm.

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Abstract Chronic myelogenous leukemia with blast crisis is seen in 15% to 20% of patients with chronic myelogenous leukemia. Chronic myelogenous leukemia with either erythroid or megakaryocytic blast crisis is not uncommon in the clinical setting. The incidence ranges from 0% to 33% in accordance with literature reports. The diagnosis of erythroid or megakaryocytic blast phase is often challenging because the percentage of blasts in the blood or bone marrow required for diagnosis has not been firmly established. Also, some myeloblasts can have aberrant expression of either erythroid or megakar

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Radford, Peter, Hasu D. L. Patel, Nicholas Hamilton, Mark Collins, and Steven Dryden. "Tympanic Membrane Rupture in the Survivors of the July 7, 2005, London Bombings." Otolaryngology–Head and Neck Surgery 145, no. 5 (2011): 806–12. http://dx.doi.org/10.1177/0194599811411143.

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Objective. The goal of this study was to analyze the prevalence of tympanic membrane rupture in the survivors of the London bombings of July 2005 and to assess whether tympanic membrane rupture provides a useful biomarker for underlying primary blast injuries. Study Design. Cross-sectional study. Subjects and Methods. Survivors of the 4 blasts of London bombings on July 7, 2005. Data were gathered from medical records and the London’s Metropolitan Police evidence documenting the injuries sustained by 143 survivors of the blasts. All patients with tympanic membrane rupture or primary blast inju

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Rauch, Philipp J., Jana M. Ellegast, Corinne C. Widmer, et al. "MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia." Blood 128, no. 18 (2016): 2253–57. http://dx.doi.org/10.1182/blood-2016-04-711986.

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Key Points AML-associated peripheral blood cytopenia is independent of bone marrow blast content, but strongly predicted by MPL expression on blast cells. MPLhi blasts scavenge TPO from serum, causing insufficient cytokine levels.

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Hadjioannou, Michalis, Aldo E. McKay, and Phillip C. Benshoof. "Full-Scale Blast Tests on a Conventionally Designed Three-Story Steel Braced Frame with Composite Floor Slabs." Vibration 4, no. 4 (2021): 865–92. http://dx.doi.org/10.3390/vibration4040049.

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This paper summarizes the findings of two full-scale blasts tests on a steel braced frame structure with composite floor slabs, which are representative of a typical office building. The aim of this research study was to experimentally characterize the behavior of conventionally designed steel braced frames to blast loads when enclosed with conventional and blast-resistant façade. The two tests involved a three-story, steel braced frame with concentrical steel braces, which are designed to resist typical gravity and wind loads without design provisions for blast or earthquake loads. During the

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Howard, Charlend K., Masahiro Yamada, Marcia Dovel, et al. "An Objective Assessment of Neuromotor Control Using a Smartphone App After Repeated Subconcussive Blast Exposure." Sensors 24, no. 21 (2024): 7064. http://dx.doi.org/10.3390/s24217064.

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Subconcussive blast exposure has been shown to alter neurological functioning. However, the extent to which neurological dysfunction persists after blast exposure is unknown. This longitudinal study examined the potential short- and long-term effects of repeated subconcussive blast exposure on neuromotor performance from heavy weapons training in military personnel. A total of 214 participants were assessed; 137 were exposed to repeated subconcussive blasts and 77 were not exposed to blasts (controls). Participants completed a short stepping-in-place task while an Android smartphone app placed

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Zhuang, Yu, Aiguo Xing, Perry Bartelt, Muhammad Bilal, and Zhaowei Ding. "Dynamic response and breakage of trees subject to a landslide-induced air blast." Natural Hazards and Earth System Sciences 23, no. 4 (2023): 1257–66. http://dx.doi.org/10.5194/nhess-23-1257-2023.

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Abstract. Landslides have been known to generate powerful air blasts capable of causing destruction and casualties far beyond the runout of sliding mass. The extent of tree damage provides valuable information on air blast intensity and impact region. However, little attention has been paid to the air blast–tree interaction. In this study, we proposed a framework to assess the tree destruction caused by powerful air blasts, including the eigenfrequency prediction method, tree motion equations and the breakage conditions. The tree is modeled as a flexible beam with variable cross-sections, and

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Vicente, Ana Isabel, Irene Luna, Juan Carlos Ruiz, et al. "WHO/ICC Classification for Myelodysplastic Neoplasms/Syndromes Performs Better for Subtype Cytomorphological Diagnosis?" Diagnostics 14, no. 15 (2024): 1631. http://dx.doi.org/10.3390/diagnostics14151631.

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The International Consensus Classification of Myeloid Neoplasms and Acute Leukemias (ICC) and the 5th edition of the WHO classification (WHO 2022) have refined the diagnosis of myelodysplastic syndromes (MDS). Both classifications segregate MDS subtypes based on molecular or cytogenetic findings but rely on the subjective assessment of blast cell percentage and dysplasia in hematopoietic cell lineages. This study aimed to evaluate interobserver concordance among 13 cytomorphologists from eight hospitals in assessing blast percentages and dysplastic features in 44 MDS patients. The study found

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Kent, W. J. "BLAT---The BLAST-Like Alignment Tool." Genome Research 12, no. 4 (2002): 656–64. http://dx.doi.org/10.1101/gr.229202.

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Kent, W. J. "BLAT---The BLAST-Like Alignment Tool." Genome Research 12, no. 4 (2002): 656–64. http://dx.doi.org/10.1101/gr.229202.

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Hunfalvay, Melissa, Nicholas P. Murray, William T. Creel, and Frederick R. Carrick. "Long-Term Effects of Low-Level Blast Exposure and High-Caliber Weapons Use in Military Special Operators." Brain Sciences 12, no. 5 (2022): 679. http://dx.doi.org/10.3390/brainsci12050679.

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Chronic low-level blast exposure has been linked with neurological alterations and traumatic brain injury (TBI) biomarkers. Impaired smooth-pursuit eye movements (SPEM) are often associated with TBI. The purpose of this study was to determine whether long-term operators of low-level blast exposure or high-caliber weapons use displayed oculomotor behaviors that differed from controls. Twenty-six members of an elite military unit performed a computerized oculomotor testing task using an eye tracker and completed a concussion assessment questionnaire. The participants were split into a blast expo

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Jiang, Shangyuan, Ariana N. Gannon, Kyle D. Smith, Marcus Brown, Junfeng Liang, and Rong Z. Gan. "Prevention of Blast-induced Auditory Injury Using 3D Printed Helmet and Hearing Protection Device – A Preliminary Study on Biomechanical Modeling and Animal." Military Medicine 186, Supplement_1 (2021): 537–45. http://dx.doi.org/10.1093/milmed/usaa317.

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ABSTRACT Introduction Repeated blast exposures result in structural damage to the peripheral auditory system (PAS) and the central auditory system (CAS). However, it is difficult to differentiate injuries between two distinct pathways: the mechanical damage in the PAS caused by blast pressure waves transmitted through the ear and the damage in the CAS caused by blast wave impacts on the head or traumatic brain injury. This article reports a preliminary study using a 3D printed chinchilla “helmet” as a head protection device associated with the hearing protection devices (e.g., earplugs) to iso

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Hu, Xuezi, Korsuk Sirinukunwattana, Ka Ho Tam, Alan Aberdeen, Daniel Royston, and Carlo Pescia. "AI-Driven Quantitation of Blast Cells and Vessel Density in Bone Marrow Biopsies Highlights Limitations of Manual Assessment." Blood 144, Supplement 1 (2024): 2227. https://doi.org/10.1182/blood-2024-203118.

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Introduction: Accurate assessment of blast cells using CD34 immunohistochemistry (IHC) in bone marrow trephines (BMTs) is essential for diagnosing myeloid neoplasms, monitoring disease progression, and guiding treatment. Accurate blast quantitation is particularly important for classifying acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS), particularly with the recent introduction of the MDS/AML category in the International Consensus Classification (ICC), which lowers the threshold for AML-like therapies to a 10% blast cutoff. In myeloproliferative neoplasms (MPN), blast quanti

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Agus, D. B., C. D. Surh, and J. Sprent. "Reentry of T cells to the adult thymus is restricted to activated T cells." Journal of Experimental Medicine 173, no. 5 (1991): 1039–46. http://dx.doi.org/10.1084/jem.173.5.1039.

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To seek information on the capacity of mature T cells to migrate to the thymus, mice were injected with Thy-1-marked populations enriched for resting T cells or T blast cells; localization of the donor cells in the host thymus was assessed by staining cryostat sections of thymus and by FACS analysis of cell suspensions. With injection of purified resting T cells, thymic homing was extremely limited, even with injection of large doses of cells. By contrast, in vivo generated T blast cells migrated to the thymus in substantial numbers. Thymic homing by T blasts was greater than 50-fold more effi

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Sutherland, HJ, A. Blair, and RW Zapf. "Characterization of a hierarchy in human acute myeloid leukemia progenitor cells." Blood 87, no. 11 (1996): 4754–61. http://dx.doi.org/10.1182/blood.v87.11.4754.bloodjournal87114754.

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Despite the usual uniform and primitive appearance of cells derived from the leukemic clone in most patients with acute myeloid leukemia (AML), there is considerable heterogeneity among leukemic blasts, particularly with respect to their capacity to proliferate and/or self renew. We have assessed whether these differences in proliferative potential are correlated with the phenotypic changes that characterize normal hematopoiesis, which might suggest an analogous hierarchy of AML progenitors. We have used the ability of primitive AML cells to persist or produce blast colony forming cells (CFU-b

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Yacoub, Abdulraheem, and Shirene Philipose. "The Diagnostic Value of Circulating Blasts in Patients with Myeloproliferative Neoplasms in Accelerated or Blast Phase." Blood 142, Supplement 1 (2023): 6422. http://dx.doi.org/10.1182/blood-2023-184761.

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Introduction: Myeloproliferative neoplasms (MPNs) are progressive cancers with variable propensity to transform to accelerated phase and blast phase (APBP), an acute leukemia-equivalent state. MPN in APBP is associated with very poor prognosis with shortened survival and is notorious for poor response to therapy. The only curative therapy is allogeneic stem cell transplant. Blast phase is defined by 20% blasts or higher in the bone marrow biopsy (BMBx) or peripheral blood (PB), while accelerated phase is defined by blast percentage 10% or higher. The diagnosis, and response to therapy often re

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NG, E. Y. K., and L. L. TAY. "STUDY OF BLAST DNA MATCHING TOOLKITS." Journal of Mechanics in Medicine and Biology 04, no. 03 (2004): 341–59. http://dx.doi.org/10.1142/s0219519404001090.

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The beginning of bioinformatics saw the development of algorithms that enabled the storage of nucleic acid and protein sequences in the form of annotated databases in a manner that would allow researchers to exchange information about gene and protein sequences easily and quickly. Databases are growing extremely fast, hence it is essential to use the current databases, which are easily available on the Web. This tutorial deals with the concept of DNA matching by using BLAST programs such as BLASTN and MEGABLAST to perform similarity sequence search and to evaluate their relative effectiveness.

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Yogarajah, Meera, Phuong L. Nguyen, Rong He, et al. "Discrepancy of blast percentage between the bone marrow aspirate and biopsy and its impact on survival outcomes in patients with myelodysplastic syndromes excess blast (MDS-EB)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 7053. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.7053.

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7053 Background: The revised International Prognostic Scoring System (IPSS-R) aids in prognosticating MDS. The percentage (%) of blasts in the bone marrow is one of the major determinants of the scoring system. The aspirate blast % is utilized as the standard of care, but there could be discrepancies in the blast % reported by the aspirate and the biopsy. We aim to study the possible use of bone marrow biopsy blasts in MDS-EB in calculating IPSS-R. Methods: The MDS database was reviewed for cases of MDS-EB after due IRB approval. We calculated IPSS-R scores based on the aspirate blast % (IPSS-

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Fernández, Pablo R., Rafael Rodríguez, and Marc Bascompta. "Holistic Approach to Define the Blast Design in Quarrying." Minerals 12, no. 2 (2022): 191. http://dx.doi.org/10.3390/min12020191.

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A new approach to determine the most efficient blast design was proposed, taking the peak particle velocity (PPV) as the main constraint, while including costs, production, granulometry, air blast and carbon footprint as relevant characteristics. The research was based on a case study that registered and analyzed 548 blasts over more than 10 years, while the vibration of the blast was recorded in 32% of them. A general attenuation law and several local laws were determined based on the geological conditions of the quarry. The blast design improvement allowed one to reduce the specific consumpt

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Kim, Jung H., James A. Goodrich, Robert Situ, et al. "Periventricular White Matter Alterations From Explosive Blast in a Large Animal Model: Mild Traumatic Brain Injury or “Subconcussive” Injury?" Journal of Neuropathology & Experimental Neurology 79, no. 6 (2020): 605–17. http://dx.doi.org/10.1093/jnen/nlaa026.

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Abstract The neuropathology of mild traumatic brain injury in humans resulting from exposure to explosive blast is poorly understood as this condition is rarely fatal. A large animal model may better reflect the injury patterns in humans. We investigated the effect of explosive blasts on the constrained head minimizing the effects of whole head motion. Anesthetized Yucatan minipigs, with body and head restrained, were placed in a 3-walled test structure and exposed to 1, 2, or 3 explosive blast shock waves of the same intensity. Axonal injury was studied 3 weeks to 8 months postblast using β-a

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Devoe, Craig E., Delong Bao, Christina Trotta, Chung-Shien Lee, and Joanna Stein Fishbein. "Evaluation of prognostic factors after induction therapy in AML." Journal of Clinical Oncology 37, no. 15_suppl (2019): e18528-e18528. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e18528.

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e18528 Background: Acute myeloid leukemia (AML) is a hematologic myeloid malignancy that carries a poor prognosis. Standard of care is induction chemotherapy with daunorubicin and cytarabine also known as 7 + 3. Bone marrow aspirates are assessed on day 14 (D14) and day 28 (D28). Achievement of CR (complete remission) is predicative of overall survival (OS ).Morphological review of BM (bone marrow) on D14 remains the standard evaluation for any indication for CR. Methods: Our primary objective was to determine if blast % on the D14 bone marrow aspirate is a prognostic indicator for remission i

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Gasic, Vladimir, Branka Zukic, Biljana Stankovic, et al. "Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia." Radiology and Oncology 52, no. 3 (2018): 296–306. http://dx.doi.org/10.2478/raon-2018-0034.

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AbstractBackgroundResponse to glucocorticoid (GC) monotherapy in the initial phase of remission induction treatment in childhood acute lymphoblastic leukemia (ALL) represents important biomarker of prognosis and outcome. We aimed to study variants in several pharmacogenes (NR3C1,GSTsandABCB1) that could contribute to improvement of GC response through personalization of GC therapy.MethodsRetrospective study enrolling 122 ALL patients was carried out to analyze variants ofNR3C1(rs33389, rs33388 and rs6198),GSTT1(null genotype),GSTM1(null genotype),GSTP1(rs1695 and rs1138272) andABCB1(rs1128503,

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Elliott, Michelle A., Mark R. Litzow, Louis Letendre, et al. "Early Peripheral Blood Blast Clearance during Induction Chemotherapy for Acute Myeloid Leukemia (AML) Predicts Superior Relapse-Free Survival." Blood 110, no. 11 (2007): 1848. http://dx.doi.org/10.1182/blood.v110.11.1848.1848.

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Abstract Background: In childhood acute lymphoblastic leukemia (ALL), a rapid decline of circulating blasts in response to induction chemotherapy or prednisone is one of the most important prognostic factors for achieving remission and for relapse-free survival (RFS). However, in AML parameters of chemosensitivity have been restricted to the assessment of residual bone marrow (BM) blasts during aplasia. We hypothesized that time to peripheral blood (PB) blast clearance would have prognostic relevance with respect to RFS in AML. Methods: From 1994 to 2006 outcomes of 86 adults (47 males; median

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Bao, Delong, Chung-Shien Lee, Christina E. Trotta, and Craig Devoe. "Evaluation of Prognostic Factors after Induction Chemotherapy for Acute Myeloid Leukemia." Blood 132, Supplement 1 (2018): 5269. http://dx.doi.org/10.1182/blood-2018-99-119830.

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Abstract Purpose: Recent studies have shown that dose escalation of daunorubicin from 45mg/m2 to 90mg/m2 during acute myeloid leukemia (AML) induction showed response benefit and overall survival in patients <=65 years. Yet, the further management of patients with persistent disease based on the evaluation of D14 bone marrow has often been questioned due to lack of data. The primary purpose of this study is to evaluate the overall remission rates of patients with a positive D14 bone marrow compared with those who had a negative D14 results, and to determine if blast % on the D14 bone marrow

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Schomer, Paul. "Attention to rattles and a non-equal-energy model are required for proper sonic boom assessment." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A275. http://dx.doi.org/10.1121/10.0018829.

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This paper is concerned with the assessment of community response to sonic booms or blasts. It summarizes and analyzes the totality of results from studies in the English language that used real booms or blasts, with subjects in real buildings. In acoustics, we are accustomed to noise sources operating in accordance with the equal-energy principle (a 1 dB increase in amplitude is equivalent to a 1 dB increase in duration). The results show that rattles are the most important attribute contributing to the annoyance engendered by sonic booms/blasts, and that the process is not equal-energy. Rath

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Grari, Oussama, Assya Khermach, Nouhaila Chahid, et al. "Transformation of Chronic Myeloid Leukemia to Acute Undifferentiated Leukemia: Case Report and Literature Review." Journal of Applied Hematology 16, no. 2 (2025): 171–75. https://doi.org/10.4103/joah.joah_53_25.

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Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the BCR::ABL1 fusion gene and typically progresses through chronic, accelerated, and blast crisis phases. While blast crises often present with myeloid or lymphoid phenotypes, transformation to acute undifferentiated leukemia (AUL) is exceedingly rare and presents significant diagnostic and therapeutic challenges. We describe a 41-year-old female with CML whose disease transformed to AUL during blast crisis. Initially treated with imatinib, therapy was discontinued due to loss of response, followed by a brief,

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Loken, Michael R., Sung-Chao Chu, Wayne K. Fritschle, Dian-Kun Li, and Denise A. Wells. "Correcting Flow Cytometric Blast Counts for Blood Contamination in Bone Marrow Aspirates." Blood 110, no. 11 (2007): 4613. http://dx.doi.org/10.1182/blood.v110.11.4613.4613.

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Abstract An accurate blast count is pivotal in the diagnosis, classification and prognosis of patients with myelodysplasia. Blast counts in all previous classification schemes are based on morphologic assessment of marrow aspirates with a poor correlation to blast counts determined by flow cytometry. A significant problem in blast enumeration by flow cytometry is the variable hemodilution of the marrow during collection for flow cytometric analysis. Blast counts can vary depending on which aspirate tube is used for flow analysis, e.g., 2.4%, 1st 5ml tube; 0.62%, 2nd 5ml tube; 0.58% 3rd 5ml tub

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Murohashi, I., S. Tohda, T. Suzuki, K. Nagata, Y. Yamashita, and N. Nara. "Autocrine growth mechanisms of the progenitors of blast cells in acute myeloblastic leukemia." Blood 74, no. 1 (1989): 35–41. http://dx.doi.org/10.1182/blood.v74.1.35.35.

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Abstract Autocrine growth mechanisms of leukemic blast progenitors in acute myeloblastic leukemia (AML) were investigated. Colony formation of leukemic blast progenitors was observed in 14 of 14 patients tested when purified blast cell fraction depleted of both T cells and monocytes was plated in methylcellulose without any colony-stimulating factor (CSF). However, there existed a minimal cell density required to initiate blast progenitor growth with marked patient-to-patient variation. To clarify the role of cell density on the spontaneous growth of blast progenitors, we tested whether leukem

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Murohashi, I., S. Tohda, T. Suzuki, K. Nagata, Y. Yamashita, and N. Nara. "Autocrine growth mechanisms of the progenitors of blast cells in acute myeloblastic leukemia." Blood 74, no. 1 (1989): 35–41. http://dx.doi.org/10.1182/blood.v74.1.35.bloodjournal74135.

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Autocrine growth mechanisms of leukemic blast progenitors in acute myeloblastic leukemia (AML) were investigated. Colony formation of leukemic blast progenitors was observed in 14 of 14 patients tested when purified blast cell fraction depleted of both T cells and monocytes was plated in methylcellulose without any colony-stimulating factor (CSF). However, there existed a minimal cell density required to initiate blast progenitor growth with marked patient-to-patient variation. To clarify the role of cell density on the spontaneous growth of blast progenitors, we tested whether leukemic cells

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Slingerland, JM, MD Minden, and S. Benchimol. "Mutation of the p53 gene in human acute myelogenous leukemia." Blood 77, no. 7 (1991): 1500–1507. http://dx.doi.org/10.1182/blood.v77.7.1500.1500.

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Abstract Heterogeneity of p53 protein expression is seen in blast cells of patients with acute myelogenous leukemia (AML). p53 protein is detected in the blasts of certain AML patients but not in others. We have identified p53 protein variants with abnormal mobility on gel electrophoresis and/or prolonged half-life (t 1/2). We have sequenced the p53 coding sequence from primary blast cells of five AML patients and from the AML cell line (OCIM2). In OCIM2, a point mutation in codon 274 was identified that changes a valine residue to aspartic acid. A wild type p53 allele was not detected in thes

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Slingerland, JM, MD Minden, and S. Benchimol. "Mutation of the p53 gene in human acute myelogenous leukemia." Blood 77, no. 7 (1991): 1500–1507. http://dx.doi.org/10.1182/blood.v77.7.1500.bloodjournal7771500.

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Heterogeneity of p53 protein expression is seen in blast cells of patients with acute myelogenous leukemia (AML). p53 protein is detected in the blasts of certain AML patients but not in others. We have identified p53 protein variants with abnormal mobility on gel electrophoresis and/or prolonged half-life (t 1/2). We have sequenced the p53 coding sequence from primary blast cells of five AML patients and from the AML cell line (OCIM2). In OCIM2, a point mutation in codon 274 was identified that changes a valine residue to aspartic acid. A wild type p53 allele was not detected in these cells.

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Collier, Zachary J., Katherine J. Choi, Ian F. Hulsebos, Christopher H. Pham, Haig A. Yenikomshian, and Justin Gillenwater. "123 A Novel Way of Thinking About Blast Injury Classification." Journal of Burn Care & Research 42, Supplement_1 (2021): S82—S83. http://dx.doi.org/10.1093/jbcr/irab032.127.

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Abstract Introduction Blast injuries present unique challenges to civilian and military healthcare providers because of the complex and often severe nature of injuries spanning numerous anatomical regions, tissue types, and organ systems. Due to these factors, we devised a novel wound-focused classification system for implementation during triage and management of blast injuries to optimize outcomes and applied this system to patients treated at an ABA-certified burn center over 5 years. Methods A retrospective analysis of patients treated by an ABA-certified burn center for blast-related inju

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Shponka, V., S. Kroft, A. M. Harrington, K. Monahan, and E. Atallah. "Non-Acute Myeloid Neoplasms With CD34(-) Blasts: Immunophenotypic And Clinical Analysis Of 5 Cases." American Journal of Clinical Pathology 154, Supplement_1 (2020): S105—S106. http://dx.doi.org/10.1093/ajcp/aqaa161.231.

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Abstract Introduction/Objective Non-acute myeloid neoplasms (NAMNs) comprise clonal hematopoietic disorders, characterized by ≤20% myeloblasts in the peripheral blood (PB) and/or bone marrow (BM). The blasts of NAMN are almost exclusively CD34(+), contrasting with blasts in some acute myeloid leukemias (AML). We detail the clinicopathologic features of NAMN with CD34(-) blasts. Methods We searched 981 NAMN pathology reports for CD34(-) blasts by flow cytometry (FC). 8-color FC data was analyzed using cluster analysis to identify all relevant cell populations with a comprehensive antibody panel

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