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Journal articles on the topic 'Blastoma'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Akhila Vemulakonda, Lakshmisree, Yaritzy Astudillo, and Elayna Maxx Shanker. "Case report of pleuropulmonary blastoma: The heterogenous features of a rare primitive neoplasm of the thorax." Journal of Case Reports and Images in Pathology 9, no. 1 (2023): 6–10. http://dx.doi.org/10.5348/100068z11lv2023cr.

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Introduction: Pleuropulmonary blastoma (PPB) is a rare primary neoplasm of the thorax frequently diagnosed in early childhood. Pleuropulmonary blastoma arises from primitive intrathoracic mesenchyme—either pulmonary and pleural, or both. Patients with pleuropulmonary blastoma usually present with respiratory symptoms and are often misdiagnosed as pneumonia in the early clinical course. Pleuropulmonary blastoma can be further classified into types I, II, and III based on histological components. Such histological distinctions have significant implications for the treatment of these lesions as w

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2

Nicol, Kathleen K., and Kim R. Geisinger. "The Cytomorphology of Pleuropulmonary Blastoma." Archives of Pathology & Laboratory Medicine 124, no. 3 (2000): 416–18. http://dx.doi.org/10.5858/2000-124-0416-tcopb.

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Abstract Pleuropulmonary blastoma is a rare, primitive primary neoplasm of the thorax in young children. The tumor, which is often but not always associated with cystic lung lesions, may arise in pulmonary parenchyma, the mediastinum, and pleura. Histologically, it is characterized by a biphasic neoplastic population of undifferentiated-appearing small round cells and larger spindle-shaped cells. A proportion of these cancers may also manifest more specific mesenchymal differentiation. In contrast to the pulmonary blastoma of adults, a malignant epithelial component does not occur. We present

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3

Moldovan, Valentin Tiberiu, Maria Sajin, and Sergiu D. Habago. "Type II pleuropulmonary blastoma in a fetus: case report of a rare mesenchymal mediastinal tumor and literature review." Archive of Clinical Cases 11, no. 2 (2024): 41–46. http://dx.doi.org/10.22551/2024.43.1102.10286.

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Mediastinal tumors are exceedingly rare during fetal development, presenting significant diagnostic challenges and potentially leading to severe outcomes such as stillbirth or metastatic disease if not promptly identified and managed. Pleuropulmonary blastomas are primitive mesenchymal tumors often linked to mutations in the DICER1 gene, indicating a hereditary pattern associated with other common adult neoplasms with dominant inheritance. This report describes a case involving a 20-year-old Caucasian woman whose pregnancy was complicated by a stillbirth in the second trimester. Initial suspic

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4

Weisbrod, G. L., D. W. Chamberlain, and L. C. Tao. "Pulmonary Blastoma, Report of Three Cases and a Review of the Literature." Canadian Association of Radiologists Journal 39, no. 2 (1988): 130–36. https://doi.org/10.1177/084653718803900212.

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Pulmonary blastoma is one of the least common primary malignant tumors of the lung. There is considerable controversy as to its exact histogenesis; it is uncertain if it arises from a single cell or if it is a mixed tumor arising from two different cell lines. We report three patients with pulmonary blastomas, describing in detail their radiological, cytological, and histopathological features.

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5

Meteroglu, Fatih, Atalay Sahin, Serdar Monis, and Bulent Ozturk. "Pulmonary Blastoma." Respiratory Case Reports 3, no. 1 (2014): 29–32. http://dx.doi.org/10.5505/respircase.2014.36036.

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6

Pierce, Janie M., Priscilla LaCroix, Kenneth Heym, et al. "Pleuropulmonary Blastoma." Journal of Pediatric Hematology/Oncology 39, no. 8 (2017): e419-e422. http://dx.doi.org/10.1097/mph.0000000000000972.

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7

Inoue, Hayato, Kiyoshi Kasai, Jun Shinada, Hirokuni Yoshimura, and Toru Kameya. "Pulmonary Blastoma." Pathology International 42, no. 12 (1992): 884–92. http://dx.doi.org/10.1111/j.1440-1827.1992.tb01894.x.

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8

Askin, Frederic B. "Pulmonary Blastoma." American Journal of Clinical Pathology 93, no. 2 (1990): 294–95. http://dx.doi.org/10.1093/ajcp/93.2.294.

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9

Zamboni, Mauro, Deborah C. Lannes, Andreia Monteiro, et al. "Blastoma pulmonar." Revista Portuguesa de Pneumologia 13, no. 3 (2007): 391–95. http://dx.doi.org/10.1016/s0873-2159(15)30358-5.

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10

Lee, Hyun Ju, Jin Mo Goo, Kyoung Won Kim, Jung-Gi Im, and Jin-Hwan Kim. "Pulmonary blastoma." Clinical Imaging 28, no. 2 (2004): 113–18. http://dx.doi.org/10.1016/s0899-7071(03)00240-7.

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11

McKay, M. J., T. Yung, and A. O. Langlands. "Pulmonary blastoma." Clinical Oncology 2, no. 3 (1990): 173–76. http://dx.doi.org/10.1016/s0936-6555(05)80154-2.

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12

Hayden, Dorothy, and Gist Farr. "PULMONARY BLASTOMA." Southern Medical Journal 85, Supplement (1992): 3S—80. http://dx.doi.org/10.1097/00007611-199209001-00224.

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13

Fosdal, Marian B. "Pleuropulmonary Blastoma." Journal of Pediatric Oncology Nursing 25, no. 6 (2008): 295–302. http://dx.doi.org/10.1177/1043454208323292.

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14

Zamboni, Mauro, Deborah C. Lannes, Andreia Monteiro, et al. "Blastoma pulmonar." Revista Portuguesa de Pneumologia (English Edition) 13, no. 3 (2007): 391–95. http://dx.doi.org/10.1016/s2173-5115(07)70344-5.

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15

Molberg, Kyle, Frank Vuttch, David Stewart, and Jorge Albores-Saavedra. "Adrenocortical blastoma." Human Pathology 23, no. 10 (1992): 1187–90. http://dx.doi.org/10.1016/0046-8177(92)90040-a.

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16

Kawano, Ryoji, Enjo Hata, Shingo Ikeda, and Toshiya Yokota. "Pulmonary blastoma." Japanese Journal of Thoracic and Cardiovascular Surgery 53, no. 11 (2005): 611–14. http://dx.doi.org/10.1007/s11748-005-0149-9.

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17

Shuja, Jamila, Iftikhar Ahmad, Khushnaseeb Ahmad, et al. "Pleuropulmonary blastoma." Journal of Cancer Research and Practice 4, no. 3 (2017): 111–14. http://dx.doi.org/10.1016/j.jcrpr.2017.03.004.

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18

Prasad, Alpana, P. Choudhry, Y. K. Sarin, and R. K. Saran. "Pulmonary blastoma." Indian Journal of Pediatrics 68, no. 8 (2001): 793–96. http://dx.doi.org/10.1007/bf02752427.

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19

Venkatramani, Rajkumar, Marcio H. Malogolowkin, Larry Wang, and Leo Mascarenhas. "Pleuropulmonary Blastoma." Journal of Pediatric Hematology / Oncology 34, no. 5 (2012): e182-e185. http://dx.doi.org/10.1097/mph.0b013e3182546adf.

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20

Oba, Yuji, Gary A. Salzman, and Roberto N. Miranda. "Pulmonary Blastoma." Journal of Bronchology 11, no. 3 (2004): 198–99. http://dx.doi.org/10.1097/01.lab.0000130635.18770.4b.

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21

Granata, C., C. Gambini, C. Carlini, et al. "Pleuropulmonary Blastoma." European Journal of Pediatric Surgery 11, no. 4 (2001): 271–73. http://dx.doi.org/10.1055/s-2001-17149.

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22

JACOBSEN, MARIANNE, and DORTHE FRANCIS. "PULMONARY BLASTOMA." Acta Pathologica Microbiologica Scandinavica Section A Pathology 88A, no. 1-6 (2009): 151–60. http://dx.doi.org/10.1111/j.1699-0463.1980.tb02480.x.

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23

Scheithauer, Bernd W., Kalman Kovacs, Eva Horvath, et al. "Pituitary blastoma." Acta Neuropathologica 116, no. 6 (2008): 657–66. http://dx.doi.org/10.1007/s00401-008-0388-9.

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24

Priest, John R., Michael B. McDermott, Smita Bhatia, Jan Watterson, J. Carlos Manivel, and Louis P. Dehner. "Pleuropulmonary blastoma." Cancer 80, no. 1 (1997): 147–61. http://dx.doi.org/10.1002/(sici)1097-0142(19970701)80:1<147::aid-cncr20>3.0.co;2-x.

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25

Cutler, Corey S., Ren� P. Michel, Miriam Yassa, and Adrian Langleben. "Pulmonary blastoma." Cancer 82, no. 3 (1998): 462–67. http://dx.doi.org/10.1002/(sici)1097-0142(19980201)82:3<462::aid-cncr6>3.0.co;2-r.

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26

Baraniya, Jitendra, Sangeeta Desai, Shubhada Kane, et al. "Pleuropulmonary blastoma." Medical and Pediatric Oncology 32, no. 1 (1999): 52–56. http://dx.doi.org/10.1002/(sici)1096-911x(199901)32:1<52::aid-mpo11>3.0.co;2-r.

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27

Wright Jr., James R. "Pleuropulmonary blastoma." Cancer 88, no. 12 (2000): 2853–58. http://dx.doi.org/10.1002/1097-0142(20000615)88:12<2853::aid-cncr28>3.0.co;2-d.

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28

Indolfi, Paolo, Fiorina Casale, Modesto Carli, et al. "Pleuropulmonary blastoma." Cancer 89, no. 6 (2000): 1396–401. http://dx.doi.org/10.1002/1097-0142(20000915)89:6<1396::aid-cncr25>3.0.co;2-2.

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29

Gautam, Bishal, Sanjeev Devgarha, R. M. Mathur, and Anula Sisodiya. "Pulmonary blastoma: a case report of a rare lung tumour." International Surgery Journal 4, no. 2 (2017): 823. http://dx.doi.org/10.18203/2349-2902.isj20170244.

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Pulmonary blastomas are a rare aggressive neoplasm comprising 0.25-0.5% of all primary lung tumours. Morphologically they mimic foetal lung tissue before 4 months gestation. Study reports a case of 23-year-old male patient who came with heaviness in chest and breathing difficulty since one and a half months. On CT scan of chest, findings are suggestive of anterior mediastinal mass extending till right hila with cardiac displacement and compression. Histopathology confirmed the presence of pulmonary blastoma.

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30

Nakayama, Takashi, Takashi Ohtsuka, Akio Kazama, and Ken-ichi Watanabe. "Classic Pulmonary Blastoma: A Subtype of Biphasic Pulmonary Blastoma." Annals of Thoracic and Cardiovascular Surgery 18, no. 2 (2012): 125–27. http://dx.doi.org/10.5761/atcs.cr.11.01693.

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31

Manivel, J. Carlos, John R. Priest, Jan Watterson, et al. "Pleuropulmonary blastoma the so-called pulmonary blastoma of childhood." Cancer 62, no. 8 (1988): 1516–26. http://dx.doi.org/10.1002/1097-0142(19881015)62:8<1516::aid-cncr2820620812>3.0.co;2-3.

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32

Bobylev, Dmitry, Gregor Warnecke, Nils Dennhardt, and Alexander Horke. "Giant pleuropulmonary blastoma." European Journal of Cardio-Thoracic Surgery 50, no. 6 (2016): 1215–16. http://dx.doi.org/10.1093/ejcts/ezw217.

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33

Chintagumpala, M., C. Langston, M. Wagner, and D. H. Mahoney. "#660 Pleuropulmonary blastoma." Journal of Pediatric Hematology/Oncology 18, no. 4 (1996): 458. http://dx.doi.org/10.1097/00043426-199611000-00099.

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34

Antón-Pacheco, J., G. De Perez, A. Montero, I. Cano, and A. Jimenez. "Neonatal pulmonary blastoma." Pediatric Surgery International 11, no. 5-6 (1996): 378–79. http://dx.doi.org/10.1007/bf00497817.

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35

Kumar T, Prasanna, Nirantha S P, Pragati Rao D, and Mohammed Sameer Kundale. "Adult pulmonary blastoma." BMJ Case Reports 18, no. 3 (2025): e263276. https://doi.org/10.1136/bcr-2024-263276.

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Pulmonary blastoma, a rare and aggressive primary lung tumour, poses diagnostic challenges due to its vague clinical presentation and rarity. Here, we outline the case of a chronic smoker in his 50s presenting with cough and blood-tinged sputum. Radiological assessment revealed a mass lesion in the left upper lobe. Despite inconclusive findings from a conventional Computed Tomography (CTguided biopsy, surgical resection ultimately led to the diagnosis of biphasic pulmonary blastoma. Subsequent histopathological examination and immunohistochemistry (IHC) confirmed the diagnosis, prompting the i

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36

Messinger, Yoav H., Douglas R. Stewart, John R. Priest, et al. "Pleuropulmonary blastoma: A report on 350 central pathology-confirmed pleuropulmonary blastoma cases by the International Pleuropulmonary Blastoma Registry." Cancer 121, no. 2 (2014): 276–85. http://dx.doi.org/10.1002/cncr.29032.

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37

Hilal, Kiran, Anam Khan, Nida Sajjad, and Kumail Khandwala. "Cystic Nephroma with Pleuropulmonary Blastoma: A Rare Dual Pathology." APSP Journal of Case Reports 9, no. 1 (2018): 3. http://dx.doi.org/10.21699/ajcr.v9i1.657.

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Cystic nephroma (CN) belongs to a heterogeneous group of renal cystic tumors while pleuropulmonary blastoma is an uncommon pediatric lung neoplasm, believed to be originating either from lung tissue itself or from the pleura. Synchronous development of pleuropulmonary blastoma following cystic nephroma is a rare entity in pediatric patients. The etiology and pathogenesis of this dual pathology is still unknown. We report a case of a child who presented with an abdominal mass diagnosed as cystic nephroma on surgical resection, who later developed a thoracic lesion which was subsequently diagnos

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38

Sakata, Shinya, Sho Saeki, Sayuri Hirooka, Susumu Hirosako, Hidenori Ichiyasu, and Hirotsugu Kohrogi. "A Case of Biphasic Pulmonary Blastoma Treated with Carboplatin and Paclitaxel plus Bevacizumab." Case Reports in Oncological Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/842621.

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Background. Pulmonary blastoma is a rare lung tumor similar to fetal lung tissues. Surgical resection at early stage is more curative than other treatments, but there is no standard treatment in unresectable cases. We show a case treated with carboplatin and paclitaxel plus bevacizumab.Case. A 68-year-old man received surgical resection and was diagnosed with biphasic pulmonary blastoma (pT3N0M0 stage IIB). Metastasis to the spleen was detected six weeks after the surgery. Carboplatin, paclitaxel, and bevacizumab were administered and showed an effect on the metastasis. Four courses of the che

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39

Hachitanda, Yoichi, Chisa Aoyama, Judith K. Sato, and Hiroyuki Shimada. "Pleuropulmonary Blastoma in Childhood." American Journal of Surgical Pathology 17, no. 4 (1993): 382–91. http://dx.doi.org/10.1097/00000478-199304000-00009.

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40

Kukkady, A., V. Upadhyay, P. W. B. Pease, and Y. F. Chan. "Pleuropulmonary blastoma: four cases." Pediatric Surgery International 16, no. 8 (2000): 595–98. http://dx.doi.org/10.1007/s003830000359.

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41

Jimenez, Jorge F. "Pulmonary blastoma in childhood." Journal of Surgical Oncology 34, no. 2 (1987): 87–93. http://dx.doi.org/10.1002/jso.2930340205.

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42

Cohen, Marta, Malcolm Emms, and R. O. C. Kaschula. "Childhood Pulmonary Blastoma: A Pleuropulmonary Variant of the Adult-Type Pulmonary Blastoma." Pediatric Pathology 11, no. 5 (1991): 737–49. http://dx.doi.org/10.3109/15513819109065469.

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43

SCIOT, R., P. DAL CIN, P. BROCK, et al. "Pleuropulmonary blastoma (pulmonary blastoma of childhood): genetic link with other embryonal malignancies?" Histopathology 24, no. 6 (2007): 559–63. http://dx.doi.org/10.1111/j.1365-2559.1994.tb00576.x.

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44

Priest, John R., D. Ashley Hill, Gretchen M. Williams, et al. "Type I Pleuropulmonary Blastoma: A Report From the International Pleuropulmonary Blastoma Registry." Journal of Clinical Oncology 24, no. 27 (2006): 4492–98. http://dx.doi.org/10.1200/jco.2005.05.3595.

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Purpose Type I pleuropulmonary blastoma (PPB) is a rare, cystic lung neoplasm in infants characterized by subtle malignant changes and a good prognosis. Recurrences after type I PPB are usually advanced type II or type III neoplasms with a poor prognosis. This article describes the first collection of type I PPB cases, analyzes outcome based on treatments of surgery or surgery plus chemotherapy, and presents type I PPB management recommendations. Patients and Methods Type I PPB cases from the International PPB Registry and literature were evaluated using standard statistical methods for outcom

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45

Crawford, K., and D. L. Stocum. "Retinoic acid coordinately proximalizes regenerate pattern and blastema differential affinity in axolotl limbs." Development 102, no. 4 (1988): 687–98. http://dx.doi.org/10.1242/dev.102.4.687.

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An assay that detects position-related differences in affinity of axolotl regeneration blastema cells in vivo was used to test whether retinoic acid, which proximalizes regenerate pattern, simultaneously proximalizes blastema cell affinity. The assay involved autografting or homografting late bud forelimb blastomas derived from the wrist, elbow or midupper arm levels to the dorsal surface of the blastema-stump junction of an ipsilateral, medium-bud-stage hindlimb regenerating from the midthigh level. The grafted blastemas consistently displaced to their corresponding levels on the proximodista

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46

Dutchuk, O. V., Z. R. Kocherha, V. M. Voloshynovych, Yu I. Alekseeva, and Yu S. Tomashchuk. "Clinical case of pulmonary blastoma in a child as a disguise of community-acquired pneumonia." Modern pediatrics. Ukraine, no. 7(119) (November 29, 2021): 46–50. http://dx.doi.org/10.15574/sp.2021.119.46.

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Currently, the problem of diagnosing pleuropulmonary blastoma in children remains relevant, because this pathology often runs under the guise of other nosologies, including pneumonia, and is extremely difficult to diagnose. Currently there are no pathognomonic clinical symptoms, specific diagnostic criteria for this disease, almost 60% of patients have nonspecific symptoms. This article presents a rare clinical case of biphasic pulmonary blastoma in a child who was examined and treated at the Ivano-Frankivsk Regional Children's Clinikal Hospital Ivano-Frankivsk Regional Council. The main clini

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47

P. Schultz, K. A., G. M. Williams, D. Yu Kachanov, et al. "DICER1 syndrome and pleuropulmonary blastoma: a report from the International Pleuropulmonary Blastoma Registry." Russian Journal of Children Hematology and Oncology 4, no. 4 (2017): 9–19. http://dx.doi.org/10.17650/2311-1267-2017-4-4-13-19.

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48

A Alim, Mohammad, Dina Abo Alam, Yaser El Sayed, et al. "Pulmonary blastoma in an adult male." Journal of Lung, Pulmonary & Respiratory Research 6, no. 4 (2019): 97–99. http://dx.doi.org/10.15406/jlprr.2019.06.00216.

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Pulmonary blastoma is one of the rare lung tumors and is considered to be dissnct from other lung tumors by its pathological features, clinical course and prognosis.1 Classic pulmonary blastoma is composed of both malignant mesenchymal stroma and epithelial components resembling embryonic lung tissue. Surgery is the standard treatment and the efficacy of adjuvant chemotherapy and radiotherapy has not yet been established

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49

Sai Shalini, CN, LeenaDennis Joseph, Georgi Abraham, D. Prathiba, and S. Rajendiran. "Cytologic features of pulmonary blastoma." Journal of Cytology 26, no. 2 (2009): 74. http://dx.doi.org/10.4103/0970-9371.55226.

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50

Gaxa, Luvo, Bafana Hlatshwayo, and Aletta Lefentse Motene. "Solid (Type 3) pleuropulmonary blastoma." Case Reports International 6 (2017): 1. http://dx.doi.org/10.5348/crint-2017-32-cr-1.

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