Relevant bibliographies by topics / Bleomycin

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  2. Dissertations / Theses
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Academic literature on the topic 'Bleomycin'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 June 2025

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Journal articles on the topic "Bleomycin"

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Björkman, S., and J. Areberg. "Extensive Chemical Degradation of Bleomycin during Attempted Labelling with 51-Cr." Nuklearmedizin 38, no. 04 (1999): 120–23. http://dx.doi.org/10.1055/s-0038-1632203.

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Summary Aim: Labelling of the cytostatic agent bleomycin with 51-Cr and use of the product for biodistribution studies have been reported in the literature. The labelling procedure involves incubation for 40 min at 130° C. Since bleomycins are polar glycopeptides sensitive to hydrolytic cleavage we were concerned about possible degradation of the drug during these unfavourable conditions. We have therefore investigated the stability of bleomycin as a function of temperature and pH of the solution and attempted to achieve the maximum labelling efficiency with minimal degradation of the two principal bleomycin components. Methods: The chemical stability of unlabelled bleomycin was investigated under labelling conditions at 130° C and in buffer of pH 1-6 at room temperature (23° C) and 60° C. The samples were assayed by high-performance liquid chromatography (HPLC). The labelling efficiency of the 51-Cr-bleomycin complex was determined by thin layer chromatography and activity measurement with a high pure Germanium (HPGe)-detector at various incubation temperatures and times. Results: Comparisons of rates of degradation of bleomycin with labelling efficiency as functions of temperature and time showed that under no condition could satisfactory labelling (>97%) be obtained without considerable degradation of bleomycin. Conclusion: Labelling of bleomycin with 51-Cr does not yield a product suitable for investigations in patients.
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Covington and Lehmann. "Disturbance of the Conformation of DNA Hairpin Containing the 5′-GT-3′ Binding Site Caused by Zn(II)bleomycin-A5 Studied through NMR Spectroscopy." Magnetochemistry 5, no. 3 (2019): 52. http://dx.doi.org/10.3390/magnetochemistry5030052.

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The antibiotics known as bleomycins constitute a family of natural products clinically employed for the treatment of a wide spectrum of cancers. These antibiotics have the ability to chelate a metal center, most commonly Fe(II), and cause site-specific DNA cleavage upon oxidation. Bleomycin therapy is a successful course of treatment for some types of cancers. However, the risk of pulmonary fibrosis as an undesirable side effect, limits the use of the antibiotics in cancer chemotherapy. Bleomycins are differentiated by their C-terminal, or tail, regions, which have been shown to closely interact with DNA. Pulmonary toxicity has been correlated to the chemical structure of the bleomycin C-termini through biochemical studies performed in mice. In the present study, we examined the binding of Zn(II)Bleomycin-A5 to a DNA hairpin of sequence 5′-CCAGTATTTTTACTGG-3′, containing the 5′-GT-3′ binding site. The results were compared to those from a previous study that examined the binding of Zn(II)Bleomycin-A2 and Zn(II)Peplomycin to the same DNA hairpin. We provide evidence that, as shown for DNA hairpins containing the 5′-GC-3′ binding site, Zn(II)BLM-A5 causes the most significant structural changes to the oligonucleotide.
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&NA;. "Bleomycin see Cisplatin/vinblastine/bleomycin." Reactions Weekly &NA;, no. 288 (1990): 6. http://dx.doi.org/10.2165/00128415-199002880-00012.

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&NA;. "Bleomycin see Cisplatin/etoposide/bleomycin." Reactions Weekly &NA;, no. 299 (1990): 5. http://dx.doi.org/10.2165/00128415-199002990-00012.

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&NA;. "Bleomycin see Cisplatin/vinblastine/bleomycin." Reactions Weekly &NA;, no. 305 (1990): 4. http://dx.doi.org/10.2165/00128415-199003050-00011.

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&NA;. "Bleomycin see Cisplatin/bleomycin/vincristine." Reactions Weekly &NA;, no. 316 (1990): 4. http://dx.doi.org/10.2165/00128415-199003160-00018.

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&NA;. "Bleomycin see Vincristine/cisplatin/bleomycin." Reactions Weekly &NA;, no. 334 (1991): 4. http://dx.doi.org/10.2165/00128415-199103340-00013.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1382 (2011): 12. http://dx.doi.org/10.2165/00128415-201113820-00040.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 706 (1998): 6. http://dx.doi.org/10.2165/00128415-199807060-00015.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 738 (1999): 6. http://dx.doi.org/10.2165/00128415-199907380-00010.

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Dissertations / Theses on the topic "Bleomycin"

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Absalon, Michael Joseph. "DNA double-strand cleavage mediated by bleomycin." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/11927.

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Nightingale, Karl. "DNA sequence recognition by the antitumour antibiotic bleomycin." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241056.

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Currier, Sophie (Sophie Christine) 1974. "Genetic requirements for protection against bleomycin toxicity in Escherichia coli." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/73345.

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Thesis (S.M.)--Massachusetts Institute of Technology, Division of Bioengineering and Environmental Health, 1999.<br>Includes bibliographical references (leaves 46-51).<br>Bleomycin is known to cause double strand breaks in vitro. Little is known, however, about its mechanism of genotoxicity in vivo. One way to probe the mechanism of genotoxicity of a DNA damaging agent in vivo is to compare the relative sensitivities of a wild type Escherichia coli strain to a panel of isogenic repair deficient mutants. If the pathway defective in the mutant is known (e.g., base excision repair, alkyl transferase repair, nucleotide excision repair, and so on), the sensitivity of the mutant can reveal mechanistic insight into the mode of killing by the DNA damaging agent. In this study, mutants deficient in recombinational repair, specifically recF, recBCD, ruvABC, recG and recGruvC, were examined for sensitivity to bleomycin. This sensitivity was tested in both dividing and non-dividing cells in order to analyze the effect of cell division on the cytotoxicity of bleomycin. When non-dividing cells were treated, the recBCD and recGruvC mutants, demonstrated high sensitivity to bleomycin. The recF mutant, on the other hand, demonstrated no sensitivity. These results were consistent with the conclusion that bleomycin induces double strand breaks in vivo that are repaired by the recombinational repair double strand break pathway. It also suggests that no damage was induced by bleomycin that required repair by the daughter strand gap pathway. Examining the sensitivity of recombinational repair deficient mutants to bleomycin also gave new insights about the mechanism of recombinational repair. Both ruvABC and recG gene products resolve Holliday junctions; however, they are thought to work on separate recombinational pathways. In this study, although the recGruvC strain was highly sensitive to bleomycin, the ruvABC and the individual recG and ruvC strains were not. This result suggested redundancy in the functions of the RecG and RuvABC proteins. Dividing cells showed a marked increase in sensitivity to bleomycin as compared to non-dividing cells. In addition, the functional redundancy of recG and ruvABC mutants was no longer seen. The ruvABC strain demonstrated high sensitivity equal to that of the recGruvC and recBCD strains whereas the recG and ruvC strains were only slightly sensitive. Under these conditions of increased cytotoxicity, additional functions of the RuvAB enzymes became important for suppression of toxicity. This result suggested a change in the mechanism of bleomycin's genotoxicity.<br>by Sophie Currier.<br>S.M.
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Highfield, Jacqueline Ann. "The synthesis and testing of novel anticancer agents related to bleomycin." Thesis, Brunel University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263514.

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Li, Huawen. "Quantitative Analysis of Bleomycin in Rat Plasma by LC-MS/MS." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1528851820162444.

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Kadokawa, Yoshio. "All-trans retinoic acid prevents radiation-or bleomycin-induced pulmonary fibrosis." Kyoto University, 2009. http://hdl.handle.net/2433/124297.

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Gäng, Dominique Patricia. "Paradoxical effects of bleomycin and heavy water (D₂O) in Mice /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Lemay, Anne-Marie. "Identification of bleomycin and radiation-induced pulmonary fibrosis susceptibility genes in mice." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92173.

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Lübke, Friedemann Norbert Gregor Ulrich. "Prävention der Bleomycin-induzierten Lungenfibrose durch inhalative Applikation von Heparin oder Urokinase." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974923818.

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Murrell, Jeffrey Michael. "Investigation of sugar biosynthesis pathways of antitumor antibiotics C-1027 and bleomycin /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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Books on the topic "Bleomycin"

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Ivan, Sikic Branimir, Rozencweig Marcel, Carter Stephen K. 1937-, Northern California Cancer Program, and Bristol Laboratories, eds. Bleomycin chemotherapy. Academic Press, 1985.

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Ramli, Martalena. Production of 101mRh and its conjugation to bleomycin. University of Manchester, 1995.

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Kampe-Juzak, Eva Christina. Liposomales Doxorubicin versus Bleomycin-Vincristin: Vergleich der Effektivität beim HIV-assoziierten Kaposi Sarkom. [s.n.], 1999.

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Lübeck, Medizinische Hochschule, ed. Fibrosierende Alveolitis als schwerwiegende Komplikation zytostatischer Therapie, speziell nach Behandlung mit Bleomycin, Busulfan und Mitomycin C. [s.n.], 1985.

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Bleomycin Chemotherapy. Elsevier, 1985. http://dx.doi.org/10.1016/c2013-0-11504-8.

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Sikic, Branimir Ivan, Marcel Rozencweig, and Stephen K. Carter. Bleomycin Chemotherapy. Elsevier Science & Technology Books, 2016.

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Glickson. Bleomycin: Chemistry and Clinical Applications. Dekker Incorporated, Marcel, 1992.

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Köllerer, Ellinor. Untersuchungen zur pulmonalen Bleomycin-Toxizität. 1987.

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Hecht, Sidney M. "Bleomycin: Chemical, Biochemical, and Biological Aspects". Springer, 2011.

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Sidik, Khalifah Bt. Characterization of repair of bleomycin-induced DNA damage in human chromatin. 1989.

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Book chapters on the topic "Bleomycin"

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Mader, Ines, Patrizia Fürst-Weger, Robert M. Mader, Elisabeth I. Semenitz, Robert Terkola, and Sabine M. Wassertheurer. "Bleomycin." In Paravasation von Zytostatika. Springer Vienna, 2002. http://dx.doi.org/10.1007/978-3-7091-3799-4_9.

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Mader, Ines, Patrizia Fürst-Weger, Robert Mader, Elisabeth Nogler-Semenitz, and Sabine Wassertheurer. "Bleomycin." In Extravasation of Cytotoxic Agents. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-211-88893-3_15.

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Schwab, Manfred. "Bleomycin." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_666-2.

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Catalano, Robert B., and Robert L. Comis. "Bleomycin." In Cancer Chemotherapy by Infusion. Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3193-0_15.

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Mader, Ines, Patrizia E. Fürst-Weger, Robert M. Mader, Elisabeth I. Semenitz, Robert Terkola, and Sabine M. Wassertheurer. "Bleomycin." In Extravasation of Cytotoxic Agents. Springer Vienna, 2003. http://dx.doi.org/10.1007/978-3-7091-3710-9_9.

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de Groot, Anton C. "Bleomycin." In Monographs In Contact Allergy. CRC Press, 2022. http://dx.doi.org/10.1201/9781003158004-76.

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Fox, K. R., and K. P. Nightingale. "Bleomycin-DNA Interactions." In Nucleic Acids and Molecular Biology. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78666-2_9.

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Tryka, A. F. "Bleomycin Induced Lung Injury." In Organ Directed Toxicities of Anticancer Drugs. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-2023-4_10.

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Gutteridge, John M. C. "Bleomycin and metal interactions." In Metal Compounds in Cancer Therapy. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1252-9_9.

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Ferguson, Nkanyezi N. "Bleomycin-Induced Flagellate Erythema." In Inpatient Dermatology. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-18449-4_17.

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Conference papers on the topic "Bleomycin"

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Mărculescu, Cătălin, Eugen Chiriac, Petruta Preda, Tiberiu Burinaru, and Marioara Avram. "Vertical Graphene-Based Electrochemical Biosensor for Detection of Bleomycin." In 2024 International Semiconductor Conference (CAS). IEEE, 2024. http://dx.doi.org/10.1109/cas62834.2024.10736730.

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Makki, I., and P. Kidambi. "Bleomycin Toxicity Controlled." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2158.

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Bogataj, Jan, I. Tancer, and A. Grošelj. "Electrochemotherapy with a Reduced Dose of Bleomycin in the Treatment of Advanced Skin Cancer. A Case Study." In Socratic Lectures 7. University of Lubljana Press, 2022. http://dx.doi.org/10.55295/psl.2022.d4.

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Squamous cutaneous skin cancer is common cancer with increasing incidence. Commonly is treated with surgery or radiotherapy, but a new technique has been emerging in recent years. Electrochemo-therapy (ECT) is innovative and still developing treatment of malignant tumors, especially effective in treating cutaneous malignancy. Its feasibility and efficacy have been proven in elderly patients with comorbidities who cannot undergo standard treatments. Some recent studies have focused on reducing bleomycin dose in elderly patients to minimalize side effects and concurrently obtain the same treatment outcome. This article presents a case study of an elder patient with advanced skin cancer, treated with electrochemotherapy with a reduced bleomycin dose, where a complete re-sponse was observed in a long-term follow-up period. Keywords: Electrochemotherapy; Bleomycin; Reduced dose; Squamous cell carcinoma; Elderly pa-tient
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Madden, Lindsey H., Leah Cushing, Jun Qian, Ping-Ping Kuang, Wellington Cardoso, and Jining Lu. "Microrna In Bleomycin Induced Pulmonary Fibrosis." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3529.

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Seo, Kwang Won, Yangjin Jegal, Seung Won Ra, Jong-Joon Ahn, Hye-Jeong Choi, and Byungsuk Kwon. "CD137 Deficiency Exacerbates Bleomycin-Induced Pulmonary Fibrosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1964.

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Wang, Ping M., and William J. Martin II. "Pulmonary Lymphangiogenesis Quantified Following Bleomycin Lung Injury." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2776.

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Ganz, S., D. Stolz, G. Zissel, B. Frye, D. Soriano, and F. Glatzki. "Imatinib als Therapieoption einer Bleomycin-induzierten Lungenschädigung." In 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. Georg Thieme Verlag, 2024. http://dx.doi.org/10.1055/s-0044-1778925.

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Voropaev, G. S., N. A. Timchenko, and A. E. Egorov. "ABILITIES OF NMR-SPECTROSCOPY FOR THE DIAGNOSIS OF RESPIRATORY DISEASES ON THE MODEL OF BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-167.

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The diagnostic system of pulmonary fibrosis is based on the metabolic analysis by NMR spectroscopy of the bronchoalveolar lavage biofluid (BAL), on the model of bleomycin-induced fibrosis in mice. The main uniqueness of the work lies in the use of the metabom8 software package in the R language for the analysis and comparison of NMR spectra without preprocessing and searching for individual metabolites.
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Manni, ML, JM Tobolewski, TW Gilbert, and TD Oury. "Extracellular Matrix Powder Attenuates Bleomycin-Induced Pulmonary Fibrosis." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2015.

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Herrmann, Franziska, Stefan-Lutz Wollin, Florian Gantner, and Eva Wex. "Olodaterol attenuates bleomycin induced lung fibrosis in mice." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa5056.

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Reports on the topic "Bleomycin"

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Hong, Zheng, Hanyu Fang, Ying Liu, Hongchun Zhang, and Wenjun Dong. Effectiveness and mechanisms of curcumin in animal models of bleomycin-associated lung injury: A preclinical systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.7.0054.

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