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Journal articles on the topic 'Bleomycin'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Björkman, S., and J. Areberg. "Extensive Chemical Degradation of Bleomycin during Attempted Labelling with 51-Cr." Nuklearmedizin 38, no. 04 (1999): 120–23. http://dx.doi.org/10.1055/s-0038-1632203.

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Summary Aim: Labelling of the cytostatic agent bleomycin with 51-Cr and use of the product for biodistribution studies have been reported in the literature. The labelling procedure involves incubation for 40 min at 130° C. Since bleomycins are polar glycopeptides sensitive to hydrolytic cleavage we were concerned about possible degradation of the drug during these unfavourable conditions. We have therefore investigated the stability of bleomycin as a function of temperature and pH of the solution and attempted to achieve the maximum labelling efficiency with minimal degradation of the two prin

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2

Covington and Lehmann. "Disturbance of the Conformation of DNA Hairpin Containing the 5′-GT-3′ Binding Site Caused by Zn(II)bleomycin-A5 Studied through NMR Spectroscopy." Magnetochemistry 5, no. 3 (2019): 52. http://dx.doi.org/10.3390/magnetochemistry5030052.

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The antibiotics known as bleomycins constitute a family of natural products clinically employed for the treatment of a wide spectrum of cancers. These antibiotics have the ability to chelate a metal center, most commonly Fe(II), and cause site-specific DNA cleavage upon oxidation. Bleomycin therapy is a successful course of treatment for some types of cancers. However, the risk of pulmonary fibrosis as an undesirable side effect, limits the use of the antibiotics in cancer chemotherapy. Bleomycins are differentiated by their C-terminal, or tail, regions, which have been shown to closely intera

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3

&NA;. "Bleomycin see Cisplatin/vinblastine/bleomycin." Reactions Weekly &NA;, no. 288 (1990): 6. http://dx.doi.org/10.2165/00128415-199002880-00012.

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4

&NA;. "Bleomycin see Cisplatin/etoposide/bleomycin." Reactions Weekly &NA;, no. 299 (1990): 5. http://dx.doi.org/10.2165/00128415-199002990-00012.

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5

&NA;. "Bleomycin see Cisplatin/vinblastine/bleomycin." Reactions Weekly &NA;, no. 305 (1990): 4. http://dx.doi.org/10.2165/00128415-199003050-00011.

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6

&NA;. "Bleomycin see Cisplatin/bleomycin/vincristine." Reactions Weekly &NA;, no. 316 (1990): 4. http://dx.doi.org/10.2165/00128415-199003160-00018.

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7

&NA;. "Bleomycin see Vincristine/cisplatin/bleomycin." Reactions Weekly &NA;, no. 334 (1991): 4. http://dx.doi.org/10.2165/00128415-199103340-00013.

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8

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1382 (2011): 12. http://dx.doi.org/10.2165/00128415-201113820-00040.

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9

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 706 (1998): 6. http://dx.doi.org/10.2165/00128415-199807060-00015.

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10

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 738 (1999): 6. http://dx.doi.org/10.2165/00128415-199907380-00010.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 747 (1999): 6. http://dx.doi.org/10.2165/00128415-199907470-00012.

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12

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1170 (2007): 12. http://dx.doi.org/10.2165/00128415-200711700-00027.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1182 (2007): 7–8. http://dx.doi.org/10.2165/00128415-200711820-00020.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1183 (2008): 8. http://dx.doi.org/10.2165/00128415-200811830-00021.

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15

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1142 (2007): 11. http://dx.doi.org/10.2165/00128415-200711420-00026.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1144 (2007): 9. http://dx.doi.org/10.2165/00128415-200711440-00027.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1148 (2007): 11. http://dx.doi.org/10.2165/00128415-200711480-00035.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1157 (2007): 10. http://dx.doi.org/10.2165/00128415-200711570-00030.

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19

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1359 (2011): 11–12. http://dx.doi.org/10.2165/00128415-201113590-00035.

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20

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1368 (2011): 10. http://dx.doi.org/10.2165/00128415-201113680-00034.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1369 (2011): 11. http://dx.doi.org/10.2165/00128415-201113690-00032.

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22

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1372 (2011): 11. http://dx.doi.org/10.2165/00128415-201113720-00028.

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23

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 544 (1995): 5. http://dx.doi.org/10.2165/00128415-199505440-00012.

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24

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 548 (1995): 6. http://dx.doi.org/10.2165/00128415-199505480-00017.

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25

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 585 (1996): 4. http://dx.doi.org/10.2165/00128415-199605850-00013.

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26

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 425 (1992): 5. http://dx.doi.org/10.2165/00128415-199204250-00011.

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27

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 439 (1993): 5. http://dx.doi.org/10.2165/00128415-199304390-00016.

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28

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 441 (1993): 6. http://dx.doi.org/10.2165/00128415-199304410-00017.

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29

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 446 (1993): 7. http://dx.doi.org/10.2165/00128415-199304460-00028.

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30

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 449 (1993): 6. http://dx.doi.org/10.2165/00128415-199304490-00014.

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31

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 455 (1993): 6. http://dx.doi.org/10.2165/00128415-199304550-00017.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 456 (1993): 6. http://dx.doi.org/10.2165/00128415-199304560-00027.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 466 (1993): 6. http://dx.doi.org/10.2165/00128415-199304660-00021.

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34

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 629 (1996): 6. http://dx.doi.org/10.2165/00128415-199606290-00013.

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35

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 654 (1997): 6. http://dx.doi.org/10.2165/00128415-199706540-00014.

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36

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 843 (2001): 6. http://dx.doi.org/10.2165/00128415-200108430-00012.

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37

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1398 (2012): 10–11. http://dx.doi.org/10.2165/00128415-201213980-00033.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1407 (2012): 14. http://dx.doi.org/10.2165/00128415-201214070-00046.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1408 (2012): 10. http://dx.doi.org/10.2165/00128415-201214080-00029.

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40

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1413 (2012): 13. http://dx.doi.org/10.2165/00128415-201214130-00043.

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41

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 367 (1991): 5. http://dx.doi.org/10.2165/00128415-199103670-00012.

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42

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 372 (1991): 3. http://dx.doi.org/10.2165/00128415-199103720-00011.

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&NA;. "Bleomycin." Reactions Weekly &NA;, no. 378 (1991): 4. http://dx.doi.org/10.2165/00128415-199103780-00011.

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44

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 389 (1992): 6. http://dx.doi.org/10.2165/00128415-199203890-00016.

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45

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 393 (1992): 7. http://dx.doi.org/10.2165/00128415-199203930-00010.

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46

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 397 (1992): 5. http://dx.doi.org/10.2165/00128415-199203970-00011.

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47

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 412 (1992): 5. http://dx.doi.org/10.2165/00128415-199204120-00014.

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48

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 420 (1992): 5. http://dx.doi.org/10.2165/00128415-199204200-00012.

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49

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1216 (2008): 10. http://dx.doi.org/10.2165/00128415-200812160-00022.

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50

&NA;. "Bleomycin." Reactions Weekly &NA;, no. 1222 (2008): 9. http://dx.doi.org/10.2165/00128415-200812220-00025.

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