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Brown, G. M., M. G. Gouda, and R. E. Miller. "Block acknowledgment: redesigning the window protocol." IEEE Transactions on Communications 39, no. 4 (1991): 524–32. http://dx.doi.org/10.1109/26.81740.
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Edwards, Nicholas Jain, David Tonny Brain, Stephen Carinna Joly, and Mariana Karry Masucato. "Hadoop distributed file system mechanism for processing of large datasets across computers cluster using programming techniques." International research journal of management, IT and social sciences 6, no. 6 (2019): 1–16. http://dx.doi.org/10.21744/irjmis.v6n6.739.
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In this paper, we have proved that the HDFS I/O operations performance is getting increased by integrating the set associativity in the cache design and changing the pipeline topology using fully connected digraph network topology. In read operation, since there is huge number of locations (words) at cache compared to direct mapping the chances of miss ratio is very low, hence reducing the swapping of the data between main memory and cache memory. This is increasing the memory I/O operations performance. In Write operation instead of using the sequential pipeline we need to construct the fully connected graph using the data blocks listed from the NameNode metadata. In sequential pipeline, the data is getting copied to source node in the pipeline. Source node will copy the data to next data block in the pipeline. The same copy process will continue until the last data block in the pipeline. The acknowledgment process has to follow the same process from last block to source block. The time required to transfer the data to all the data blocks in the pipeline and the acknowledgment process is almost 2n times to data copy time from one data block to another data block (if the replication factor is n).
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Chen, Chen, Honghui Zhao, Tie Qiu, Ronghui Hou, and Arun Kumar Sangaiah. "A multi-station block acknowledgment scheme in dense IoT networks." Computer Communications 119 (April 2018): 179–90. http://dx.doi.org/10.1016/j.comcom.2017.11.006.
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Yun, J. H. "Reliable rate adaptation for block acknowledgment in IEEE 802.11e wireless LANs." Electronics Letters 44, no. 3 (2008): 216. http://dx.doi.org/10.1049/el:20083418.
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Ferguson, Christopher J., and Moritz Heene. "A Vast Graveyard of Undead Theories." Perspectives on Psychological Science 7, no. 6 (2012): 555–61. http://dx.doi.org/10.1177/1745691612459059.
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Publication bias remains a controversial issue in psychological science. The tendency of psychological science to avoid publishing null results produces a situation that limits the replicability assumption of science, as replication cannot be meaningful without the potential acknowledgment of failed replications. We argue that the field often constructs arguments to block the publication and interpretation of null results and that null results may be further extinguished through questionable researcher practices. Given that science is dependent on the process of falsification, we argue that these problems reduce psychological science’s capability to have a proper mechanism for theory falsification, thus resulting in the promulgation of numerous “undead” theories that are ideologically popular but have little basis in fact.
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Henna, Shagufta, and Muhammad Awais Sarwar. "An Adaptive Backoff Mechanism for IEEE 802.15.4 Beacon-Enabled Wireless Body Area Networks." Wireless Communications and Mobile Computing 2018 (June 26, 2018): 1–15. http://dx.doi.org/10.1155/2018/9782605.
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Carrier sense multiple access mechanism with collision avoidance (CSMA/CA) in IEEE 802.15.4-based wireless body area networks (WBANs) may impair the transmission reliability of emergency traffic under high traffic loads, which may result in loss of high valued medical information. Majority of the recent proposals recommend an early retransmission of failed frame while ignoring the history of past failed transmissions. More importantly, these proposals do not consider the number of failed transmissions experienced by each sensor node, thereby affecting the reliability of retransmissions. In this paper, we propose a dynamic retransmission adaptive intelligent MAC (RAI-MAC) scheme. In our proposed scheme retransmission class of each sensor node is decided by the coordinator according to the number of failed transmissions of each node as observed by the coordinator during the last superframe. Based on the retransmission class received from the coordinator, each node adjusts its next backoff value. The proposed scheme increases the probability of successful frame retransmissions without incurring extra overhead. The simulation results prove that the proposed scheme based on its adaptive retransmission mechanism achieves higher average throughput and average end-to-end delay, while not compromising on energy efficiency as compared to the IEEE 802.15.4 and Block Acknowledgment (Block Ack). Moreover, our scheme appears more stable in terms of average throughput, end-to-end delay, and energy efficiency under different values of beacon order (BO) and superframe order (SO).
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Ibrahim, Muhammad K., Mahmoud H. Ismail, and M. Watheq El-Kharashi. "Novel Distributed Scheduling Algorithms for mmWave Mesh Networks." Journal of Circuits, Systems and Computers 27, no. 08 (2018): 1850118. http://dx.doi.org/10.1142/s0218126618501189.
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This paper addresses throughput improvement in millimeter-wave (mmWave) mesh networks via two novel distributed scheduling algorithms. The first one uses packet aggregation and block acknowledgment (ACK) that were introduced in the IEEE Std 802.11e-2005 for WiFi. Specifically, a distributed time-division multiplexing scheduling algorithm, which targets increasing the network capacity via reserving as many contiguous slots as possible for each node, is proposed thus enabling packet aggregation. This algorithm achieves its goal when the operating signal-to-noise ratio (SNR) is significantly high. If that is not the case, the second proposed algorithm can be used. It is a distributed one that starts initially with a random feasible schedule determined cooperatively between nodes. The algorithm then tries to reach better feasible schedules via parallel and successive local searches without violating feasibility constraints. Extensive simulations show that the first algorithm improves the network throughput by almost [Formula: see text] compared to the well-known memory-guided directional medium access control (MDMAC) due to reducing the transmission overhead. The second proposed algorithm is shown to increase the number of reserved slots by about [Formula: see text] over MDMAC. Both algorithms are shown to either increase or almost maintain the same degree of fairness among the nodes as quantified by Jain’s fairness index.
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Xu, Gang, and Liang Ma. "Resilient Self-Triggered Control for Voltage Restoration and Reactive Power Sharing in Islanded Microgrids under Denial-of-Service Attacks." Applied Sciences 10, no. 11 (2020): 3780. http://dx.doi.org/10.3390/app10113780.
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This paper addresses the problem of voltage restoration and reactive power sharing of inverter-based distributed generations (DGs) in an islanded microgrid subject to denial-of-service (DoS) attacks. Note that DoS attacks may block information exchange among DGs by jamming the communication network in the secondary control level of a microgrid. A two-layer distributed secondary control framework is presented, in which a state observer employing the multiagent system (MAS)-based ternary self-triggered control is implemented for discovering the average information of voltage and reactive power in a fully distributed manner while highly reducing communication burden than that the periodic communication way. The compensation for the reference signal to the primary control is acquired according to the average estimates to achieve voltage restoration while properly sharing reactive power among DGs. An improved ternary self-triggered control strategy integrating an acknowledgment (ACK)-based monitoring mechanism is established, where DoS attacks are modeled by repeated cycles of jamming and sleeping. A new triggering condition is developed to guarantee the successful information exchange between DGs when the sleep period of DoS attacks is detected. Using the Lyapunov approach, it is proved that the proposed algorithm allows agents to reach consensus regardless of the frequency of the DoS attacks, which maintains the accurate estimation of average information and the implementation of the secondary control objectives. The performance of the proposed control scheme is evaluated under simulation and experimental conditions. The results show that the proposed secondary control scheme can highly reduce the inter-agent communication as well as improve the robustness of the system to resist DoS attacks.
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Chrysler, Susan T., Paul J. Carlson, Brad Brimley, and Eun Sug Park. "Effects of Full Matrix Color Changeable Message Signs on Legibility and Roadway Hazard Visibility." Transportation Research Record: Journal of the Transportation Research Board 2617, no. 1 (2017): 9–18. http://dx.doi.org/10.3141/2617-02.
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Transportation agencies are considering public–private partnerships as they struggle to fund infrastructure and operations improvements. The national Manual on Uniform Traffic Control Devices (MUTCD) allows acknowledgments of private sponsors on static signs. The legibility and visibility impacts of including logos of sponsors on changeable message signs (CMSs) were examined. Thirty drivers participated in a closed-course study during daytime and nighttime conditions. Full-sized full matrix color LED signs were used to display travel time and safety reminder messages with and without sponsor acknowledgment logos. Single- and dual-phase messages were tested. The measures of effectiveness were legibility distance for target words on the signs and roadway hazard object detection distance. Legibility distances of the CMS messages were notably greater than those of retroreflective traffic signs and well above the MUTCD threshold of 30 ft/in. During the day, the median legibility index was approximately 60 ft/in. At night, the index was approximately 45 ft/in. Sponsor logos had no significant effect on the legibility distances of travel time signs. Sponsor logos had a small effect on the legibility distance of safety message signs with a blue background but not on those with a black background. The use of sponsor logos marginally affected object detection for certain object locations. The results of this study, coupled with an earlier driving simulation evaluation showing no cognitive distraction due to logos, support the use of sponsorship acknowledgment signs on CMSs. An open road evaluation is planned before statewide implementation is enabled.
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Ming Wahl, Emma. "Black Women in Fanon's Black Skin, White Masks." Stance: an international undergraduate philosophy journal 14, no. 1 (2021): 41–51. http://dx.doi.org/10.33043/s.14.1.41-51.
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In this paper, I focus on the representations of Black women in contrast to Black men found within Frantz Fanon’s philosophical work Black Skin, White Masks. I propose that while Fanon’s racial dialectical work is very significant, he often lacks acknowledgment of the multidimensionality of the Black woman’s lived experience specifically. Drawing on the theory of intersectionality, coined by Kimberlé Crenshaw, I argue that Fanon does not recognize the different layers of oppression operating in Black women’s lives to the degree that he fails to include them within his framework of both liberation and resistance from racial oppression.
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Holloway, Pippa. "Manifesto for a Queer South Politics." Publications of the Modern Language Association of America 131, no. 1 (2016): 182–86. http://dx.doi.org/10.1632/pmla.2016.131.1.182.
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Whereas the past decade of progress for LGBTQ Americans has accompanied a turn away from liberalism and a silencing of radicalism, in that gays who face discrimination are seen as innocent victims while unarmed black men gunned down by police are seen as thugs, and in that queers celebrate judicial acknowledgment of their dignity while food stamps disappear, recipients of public assistance are tested for drugs, one third of young black men have been incarcerated, torture is an instrument of American foreign policy, and the top one percent get wildly richer each year;
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Grund, Thomas U., and James A. Densley. "Ethnic heterogeneity in the activity and structure of a Black street gang." European Journal of Criminology 9, no. 4 (2012): 388–406. http://dx.doi.org/10.1177/1477370812447738.
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Despite acknowledgment of ‘hybrid’ street gangs in the literature, there is little systematic research into ethnic heterogeneity within gangs. This research aims at moving beyond the broad categorization of the Black street gang. For this purpose, we examine an all-Black London-based gang in detail, using fieldwork and police arrest data, and investigate the role of ethnic heterogeneity for the workings of the gang. Our findings suggest that ethnic heterogeneity within this gang is crucial for its criminal operation. Although there is no evidence for ethnicity-related specialization of crime, the structural co-offending pattern of the gang’s activities is dominated by ethnicity. Ethnicity matters for who offends with whom.
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Harris, Kimberly Ann. "What Does It Mean to Move for Black Lives?" Philosophy Today 63, no. 2 (2019): 275–91. http://dx.doi.org/10.5840/philtoday2019731265.
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I argue that the key ideas of the movement for Black lives have resonances with Frantz Fanon’s ideas particularly in Black Skin, White Masks. I first demonstrate how the mission to repudiate Black demise and affirm Black humanity captures Fanon’s critique of universal humanism. The fear of the Black body was central to the testimonies of Darren Wilson, Jeronimo Yanez, and George Zimmerman (the individuals that shot and killed Mike Brown, Philando Castile, and Trayvon Martin respectively). Fanon prioritized the role of the body in his account of racism. It is difficult to not see the relevance of Fanon’s analysis when one considers these testimonies. Lastly, I demonstrate how the chants “Black lives matter,” “Hands up, don’t shoot,” and “I can’t breathe” are acknowledgments of the significance of Black lives and serve as contemporary instances of Fanon’s sociodiagnostic approach.
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Franco, Marisa, Rahel Katz, Jessica Pickens, and David L. Brunsma. "From my own flesh and blood: An exploratory examination of discrimination from family for Black/White Multiracial people." Qualitative Social Work 19, no. 2 (2018): 246–66. http://dx.doi.org/10.1177/1473325018815734.
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This qualitative study examined instances of racial discrimination from family members among 36 Black/White Multiracial individuals. Forms of discrimination included stereotyping, identity invalidation, racist comments, lack of acknowledgment, vicarious discrimination, and negativity. Participants responded to discrimination by distancing themselves from family members, resisting, and/or dismissing discrimination. Discriminatory experiences made race more salient for participants. Participants reported feeling hurt, alienated, and confused following discrimination. Implications of findings for social workers counseling Multiracial people and interracial families are discussed.
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Quiñones Martorello, A., G. Rios, A. Cano, and R. H. Alberio. "87 EFFECT OF CRYOPROTECTANT CONCENTRATION IN THE VITRIFICATION SOLUTION ON THE ZONA PELLUCIDA HARDENING AND SPERMATOZOA PENETRATION OF BOVINE OOCYTES." Reproduction, Fertility and Development 23, no. 1 (2011): 149. http://dx.doi.org/10.1071/rdv23n1ab87.
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In the murine model, it has been shown that the high concentration of cryoprotectants required for vitrification can activate the oocytes through a process mediated by calcium influx. This activation induces the zona pellucida (ZP) hardening and affects the sperm penetration. This study aimed to evaluate the effect of exposure of bovine oocytes to the vitrification solutions (VS1 and VS2) in calcium-free medium with 3 concentrations of etilenglycol (EG) and dimetylsulfoxide (DMSO) on the oocyte activation. Cumulus oocyte complexes (COC) were matured in vitro (22 h), partially denuded through pipetting in medium with hyaluronidase, and subject to four treatments: T1, untreated (control); T2, exposed to 20% EG+0% DMSO (VS1) and then 40% EG+0% DMSO (VS2); T3, 10% EG+10% DMSO (VS1) and then 20% EG+20% DMSO (VS2); and T4, 0% EG+20% DMSO (VS1) and then 0% EG+40% DMSO (VS2). The contact with each VS was 3 min and 30 s, respectively. After this, the COC were matured up to 24 h. In Expt. 1, COC were denuded and placed in a solution of pronase E in PBS (1 mg mL–1) to determine the number of oocytes with ZP digested after 9 min of exposure to the enzyme. In Expt. 2, COC were fertilized in TALP medium with 50 mg mL–1 heparin and 1 million mL–1 sperm. After 12 h, COC were denuded and stained with bisbenzimide (Hoechst 33342) and examined under epi-fluorescence. The number of oocytes indicating spermatic penetration was determined by presence of intact sperm heads, spermatic pro-nucleus, or 2 polar bodies. Data were analysed by the PROC GENMOD (SAS; see Table 1). In Expt. 1, there were no differences in the percentage of oocytes without ZP after pronase treatment in groups T1, T2, and T3. The T4 group had the lowest percentage of digestion, and T3 was not different from T4. In Expt. 2 there were no differences in the percentage of sperm penetration between T2, T3, and T4. All treatments had lower values than T1. In conclusion, bovine oocytes undergo hardening of the ZP when put in contact with the cryoprotectants, and this effect was significantly increased with the use of DMSO. Moreover, there was a decrease in sperm penetration in all treated groups, indicating that the natural blocking of polyspermy depends not only on the hardening of the ZP, but another process that could act at the plasma membrane. It is possible that cryoprotectants, regardless of their concentration, may trigger this early block through a mechanism that would be independent of calcium. Table 1.Effect of EG and DMSO concentration in the VS on the ZP hardening and sperm penetration of bovine oocytes exposed to these solutions Acknowledgment: the National Research Agency through the grant PICT 2007/1205.
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Rascado, T. S., J. F. Lima-Neto, S. E. R. S. Lorena, B. W. Minto, and F. C. Landim-Alvarenga. "396 Oct-4 EXPRESSION IN CAT INNER CELL MASS-DERIVED CELLS CULTURED IN MEDIUM WITH DIFFERENT PROTEIN SOURCES." Reproduction, Fertility and Development 22, no. 1 (2010): 354. http://dx.doi.org/10.1071/rdv22n1ab396.
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The domestic cat can be used as a biological model for humans because of similarities in some disease and genetically transmitted conditions. Embryonic stem cells might complete nuclear reprogramming more efficiently than somatic cells and, therefore, are potentially useful for increasing interspecific cloning success. The objective of this study was to establish an effective culture system for inner cell mass (ICM)-derived cells in the domestic cat, testing the ability of the ICM to attach to the culture dish and to form embryonic stem cell colonies in the presence of fetal calf serum (FCS) and Knockout serum (KS). Moreover, knowing that the transcription factor Oct-4 is important for the maintenance of pluripotency in human and murine embryonic stem cells, the expression of this factor was evaluated in in vitro-produced blastocyst and in the attached ICM. Domestic cat oocytes were matured, fertilized, and cultured in vitro until the blastocyst stage. The ICM was mechanically isolated (n = 60) using a scalpel blade and transferred to a monolayer of chemically inactivated cat fibroblasts with 10 μg mL-1 mitomicin C. The base culture media (BM) was DMEM/F12 supplemented with nonessential amino acids, glutamine, leukemia inhibitory factor, fibroblast growth factor-2, 2-mercaptoethanol, and antibiotics. Three groups were tested: G1 = BM with 20% FCS (20); G2 = BM with 20% KS (20); G3 = BM with 15% FSC and 5% KS (20). Culture was performed in a 5% CO2 in air incubator at 38.5°C. No statistical difference was observed among groups in relation to ICM attachment (chi-square, P > 0.05). Ninety percent of the ICM presented good adhesion after 3 days of culture and started to grow in all media tested. However, until now, no good colonies were formed. Fifteen blastocysts and 10 attached ICM were fixed in 3% paraformaldehyde and permeabilized in 0.2% triton X-100 in PBS. Subsequently, to block nonspecific binding of the primary antibody, the preadsorption for 2 h at room temperature with OCT4 blocking peptide (sc-8628P, Santa Cruz Biotechnology, Santa Cruz, CA, USA) was used. Samples were incubated with Oct4 antibody (N-19 : sc 8628, Santa Cruz Biotechnology) and with the appropriate secondary antibody (A21431, Invitrogen) and examined by fluorescence microscopy. Oct4 protein was detected both in the ICM and trophoderm cells, and it was distributed in cytoplasm and nuclei. These embryos were also stained with Hoechst 33342. Although further standardization of the culture media is needed, it seems that the KS can be replaced by FCS in cat embryonic stem cell culture. Furthermore, the immunostain of the trophoderm with Oct-4 indicates a difference in the expression of this factor when compared with its expression on human and murine blastocysts. This could be related to in vitro production, or Oct 4 is not a good pluripotency marker for cat embryos and cat embryonic stem cell, consequently. This fact has been noted in goat, bovine, and porcine embryos. Acknowledgment is given to FAPESP.
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Yellow Horse, Aggie J., Karen Kuo, Eleanor K. Seaton, and Edward D. Vargas. "Asian Americans’ Indifference to Black Lives Matter: The Role of Nativity, Belonging and Acknowledgment of Anti-Black Racism." Social Sciences 10, no. 5 (2021): 168. http://dx.doi.org/10.3390/socsci10050168.
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This paper assesses how ongoing historical racism and nativism as embedded within U.S. culture requires new and important dialogues about the omnipresence of White supremacy and its interconnected mechanisms that divide communities along the lines of race and perceived in-group status. To assess the role of immigration as it is understood through paradigms of White supremacy and systemic racism, the current study examines individual-level predictors of indifference to the BLM movement based on nativity status among Asian Americans—a racialized pan-ethnic group that is comprised of predominantly foreign-born members. Using the 2016 Collaborative Multiracial Post-Election Survey, one of the few nationally representative surveys that include detailed information about the Black Lives Matter movement, our study includes 1371 Asian immigrants (i.e., foreign-born Asian Americans) and 1635 U.S.-born Asian Americans. Results demonstrate that reporting indifference to the BLM movement differ by nativity such that foreign-born Asian Americans were significantly more likely to report indifference to the BLM movement compared to their U.S.-born Asian American counterparts. However, the impact of nativity disappears once we account for sense of belonging and acknowledgement of anti-Black racism. The sense of belonging was significant in predicting indifference to the BLM movement among U.S.-born Asian Americans only. The findings contribute to our understanding of racial sense making for Asian Americans as well as an understanding of how White supremacy translates to anti-Black racism through multiple and interconnected mechanisms for the maintenance of White supremacy.
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Monson, Ingrid, John Gennari, and Travis A. Jackson. "ECCENTRIC, GIFTED, AND BLACK: THELONIOUS MONK REVEALED." Du Bois Review: Social Science Research on Race 7, no. 2 (2010): 381–402. http://dx.doi.org/10.1017/s1742058x10000330.
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Do not miss Robin D. G. Kelley's Thelonious Monk: The Life and Times of an American Original, for it will stand as the definitive biography of the great American composer and pianist for many years to come. What distinguishes Kelley's treatment of Monk's complicated and enigmatic life is the sheer depth and breadth of primary research, including, for the first time, the active cooperation and involvement of Thelonious Monk's family. In his acknowledgments, Kelley describes a long process of convincing Thelonious Monk, III to grant permission culminating in a six-hour meeting in which his knowledge, credentials, and commitment were thoroughly tested and challenged. Once he had secured “Toot's” blessings, as well as that of his wife Gale and brother-in-law Peter Grain, Kelley was introduced to Nellie Monk, Thelonious Monk's wife, and a wide range of family and friends who shared their memories and personal archives of photos, recordings, and papers. This is not an authorized biography, however, since Thelonious Monk, Jr. never demanded the right to see drafts or dictate the content. Rather Kelley was admonished to “dig deep and tell the truth.”
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Subotic, Jelena. "Remembrance, Public Narratives, and Obstacles to Justice in the Western Balkans." Studies in Social Justice 7, no. 2 (2013): 265–83. http://dx.doi.org/10.26522/ssj.v7i2.1047.
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Twenty years since the onset of the traumatic wars of Yugoslav secession, the countries of the Western Balkans continue to nurture narratives of the past that are mutually exclusive, contradictory, and irreconcilable. The troubling ways in which states in the region remember their pasts provide continuing obstacles in the search for acknowledgment and justice. In this essay, I develop an argument for understanding the relationship between justice and remembrance of the past. To illustrate this relationship, I explore ways in which education and memorialization projects contribute to justice efforts. I critically analyze a few ongoing education and memory projects in the region, and then present alternative ideas on mechanisms of public memory that would be more conducive to building the foundational blocks of justice based on trust, respect, and dignity.
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Sahardevi, Zaskia Wiedya, Oky Dwi Nurhayati, and Kurniawan Teguh Martono. "Perancangan Dan Implementasi Teknologi Virtual Reality Modelling Language 3 Dimensi Pada Pengenalan Perangkat Keras Komputer Berbasis Website." Jurnal Teknologi dan Sistem Komputer 3, no. 1 (2015): 147–53. http://dx.doi.org/10.14710/jtsiskom.3.1.2015.147-153.
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The purpose of this research is to design and implement the technology of Virtual Reality Modeling Language (VRML) 3D) on the introduction of computer hardware websites based. Steps design of multimedia applications for learning media computer hardware is done by performing data collection, literature review, analysis and system design followed by implementation and testing of the system. In this research using a black-box test method, where the acknowledgment is made to test the success of the exist functions. The result of the design of this application is a web based interactive applications in the desktop containing material computer hardware and visualized in 3D VRML form of a variety of input devices, output, processing, and storage devices. In addition, the animation demo mode petrified to get to know more computer hardware.
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Kaur, Rajveer, Dr Shaveta Rani, and Dr Paramjeet Singh. "Review of Acknowledgment Based Techniques for Detection of Black Hole/Gray Hole Attacks in MANETs." INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 5, no. 3 (2013): 214–19. http://dx.doi.org/10.24297/ijct.v5i3.3522.
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In Mobile Ad hoc NETworks (MANETs) nodes communicate via wireless links, without any fixed infrastructure like base stations, central servers or mobile switching. Each node in MANET can act as a host or as a router. Due inherent characteristics like decentralization, self configuring, self -organizing networks, they can be deployed easily without need of expensive infrastructure and have wide range of military to civilian and commercial applications. But wireless medium, dynamically changing topology, limited battery and lack of centralized control in MANETs, make them vulnerable to various types of attacks. This paper focus on network layer packet dropping attacks – Black Hole & Gray Hole attacks in Dynamic Source Routing (DSR) based MANETs and discuss various pros and cons of acknowledgement based techniques for detection of above said attacks.
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Kotlín, Roman, Eliška Ceznerova, Stikarová Jana, et al. "Four Cases of Aaplha Dysfibrinogenemia in Childhood." Blood 126, no. 23 (2015): 4697. http://dx.doi.org/10.1182/blood.v126.23.4697.4697.
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Abstract Introduction Hemostasis in childhood differs from that of adults; and the hemostatic system is still developing during childhood. These differences offer a protective advantage to children with hemorrhagic and thrombotic complications. Plasma levels of coagulation factors (except for fibrinogen, factor V and factor VIII), as well as plasma levels of protein C, protein S and antithrombin are reduced. Hereditary dysfibrinogenemia is a rare disorder wherein an inherited abnormality in fibrinogen structure may result in defective fibrin function and/or structure. Clinical symptoms may vary from asymptomatic to life-threatening bleeding complications. Venous or arterial thrombotic complications occur extremely rarely during childhood. Fibrinogen, a key component in hemostasis, is a 340-kDa glycoprotein. The molecule consists of three different pairs of polypeptide chains (Aa, Bb, and g) each encoded by a distinct gene (FGA, FGB, and FGG). N-terminal parts of the Aa chain - fibrinopeptides A and the Bb chain - fibrinopeptides B are situated in the central part of the molecule and block polymerization of the molecules. Conversion of fibrinogen to fibrin occurs after the cleavage of N-terminal fibrinopeptides by the serine protease thrombin. Correct conformation of fibrinopeptides is important for the cleavage by thrombin. Methods Routine coagulation tests were performed with citrated plasma samples on a STA-R coagulation analyzer. The functional fibrinogen level was measured by the Clauss method. Total fibrinogen level was determined by an immunoturbidimetric assay performed on a UV-2401PC spectrophotometer. Fibrin polymerization induced by either thrombin or reptilase and fibrinolysis experiments were obtained by the turbidimetrical method. Fibrinopeptide release was measured as a function of time; and the fibrinopeptides were determined by the reversed-phase, high-performance liquid chromatography (RP-HPLC) method. The purified genomic DNA was amplified by polymerase chain reaction, using specific primers; and dideoxysequencing was performed with Dye Terminator Cycle Sequencing with a Quick Start kit and a CEQ 8000 genetic analysis system). Results We have examined four unrelated children suspected dysfibrinogenemia. The first patient was a 5-yr old boy with prolonged thrombin time and low functional fibrinogen level. He presented with easy bruising and epistaxis. Genetic analysis revealed a heterozygous substitution Aalpha R16H. The second patient was a 13-yr old girl with prolonged thrombin and reptilase times and low functional fibrinogen level. She presented with menorrhagia. Genetic analysis revealed a heterozygous substitution Aalpha G17V. The third patient was a 12-yr old asymptomatic boy. Genetic analysis revealed a heterozygous substitution Aalpha R16H. Kinetics of fibrinopeptide release was impaired in all these cases. The fourth patient was a 3-yr old girl with low functional fibrinogen level. She presented with easy bruising. Genetic analysis revealed a heterozygous substitution Aalpha K448N. All patients presented with impaired fibrin polymerization. Conclusion All patients were found to be heterozygous for point mutations in FGA gene. Three mutations were found in the site of fibrinopeptide cleavage and one in the alphaC-domain. Mutations had different clinical manifestations from asymptomatic to bleeding. Mutations Aalpha Arg16His and Aalpha Gly17Val are among the most common fibrinogen mutations and both decelerate fibrinopeptide A cleavage from mutant fibrinogens. We describe here a novel previously unreported mutation Aalpha Lys448Asn affecting fibrin formation. Acknowledgment This work was supported by the project of the Ministry of Health of the Czech Republic for conceptual development of the research organization 00023736, by Grant from the Academy of Sciences, Czech Republic (P205/12/G118), and by ERDF OPPK CZ.2.16/3.1.00/28007. Disclosures No relevant conflicts of interest to declare.
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Caughie, Pamela L. "Let It Pass: Changing the Subject, Once Again." PMLA/Publications of the Modern Language Association of America 112, no. 1 (1997): 26–39. http://dx.doi.org/10.2307/463051.
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The recent controversial transformation of the humanities is due partly to the institutional acknowledgment of diversity and partly to critics' efforts to theorize difference and to destabilize the categories of identity on which programs devoted to the study of diversity are founded. This double agenda creates anxiety over the positions we find ourselves in as scholars and teachers in the newly configured university. My essay offers a means of working through this tension: a performative pedagogy based on a descriptive theory of the dynamics of passing. I exemplify this dynamic by reading debates on white feminists' appropriation of black women's writing, comparing student responses to the 1934 film Imitation of Life, and discussing Fannie Hurst's novel on which the film is based. I posit the pedagogical relation as the privileged site where passing, which is inevitable in any subject position, can be enacted and made explicit.
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Hendrix, Donna K., Steven E. Brenner, and Stephen R. Holbrook. "RNA structural motifs: building blocks of a modular biomolecule." Quarterly Reviews of Biophysics 38, no. 3 (2005): 221–43. http://dx.doi.org/10.1017/s0033583506004215.
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1. Introduction 2222. What is an RNA motif? 2222.1 Sequence vs. structural motifs 2222.2 RNA structural motifs 2232.3 RNA structural elements vs. motifs 2232.4 Specific recognition motifs 2242.5 Tools for identifying and classifying elements and motifs 2263. Types of RNA structural motifs 2283.1 Helices 2283.2 Hairpin loops 2283.3 Internal loops 2303.4 Junction loops/multiloops 2303.5 Binding motifs 2323.5.1 Metal binding 2323.5.2 Natural and selected aptamers 2343.6 Tertiary interactions 2344. Future directions 2365. Acknowledgments 2396. References 239RNAs are modular biomolecules, composed largely of conserved structural subunits, or motifs. These structural motifs comprise the secondary structure of RNA and are knit together via tertiary interactions into a compact, functional, three-dimensional structure and are to be distinguished from motifs defined by sequence or function. A relatively small number of structural motifs are found repeatedly in RNA hairpin and internal loops, and are observed to be composed of a limited number of common ‘structural elements’. In addition to secondary and tertiary structure motifs, there are functional motifs specific for certain biological roles and binding motifs that serve to complex metals or other ligands. Research is continuing into the identification and classification of RNA structural motifs and is being initiated to predict motifs from sequence, to trace their phylogenetic relationships and to use them as building blocks in RNA engineering.
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Price, Yasmina. "Tearing, Stitching, Quilting." Film Quarterly 75, no. 1 (2021): 23–32. http://dx.doi.org/10.1525/fq.2021.75.1.23.
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This article analyses the short film and multi-screen installation of America (2019/2020) and the documentary feature Time (2020) by Garrett Bradley as works of radical historiography. The materiality of the gestures of tearing and stitching are a key to understanding Bradley’s methodology as a double gesture of disassembly and reassembly. The use of the lost and recovered fragments of the 1913 Lime Kiln Club Field Day in America and private self-documentation of home movies in Time offer disrupt dominant forms of history. Bradley’s distinctive strategy is a suturing of these archival materials with her own contemporary footage, yielding an aesthetic of fluid black-and-white quilting. Bradley’s abolition poetics function as an urgent contemporary process of recovery that, without ignoring or eliding the traumas of present or past violence, suggests that there can yet be an acknowledgment of the generative potential of the beauty processes of survival that have always been generated alongside them.
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Heydari, Vahid, and Seong-Moo Yoo. "E2EACK: an end-to-end acknowledgment-based scheme against collusion black hole and slander attacks in MANETs." Wireless Networks 22, no. 7 (2015): 2259–73. http://dx.doi.org/10.1007/s11276-015-1098-6.
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Fiori, Katherine L., Amy J. Rauer, Kira S. Birditt, et al. "“I Love You, Not Your Friends”." Journal of Social and Personal Relationships 35, no. 9 (2017): 1230–50. http://dx.doi.org/10.1177/0265407517707061.
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Research on the merging of social networks among married couples tends to focus on the benefits of increased social capital, with the acknowledgment of potential stressors being limited primarily to in-law relationships. The purpose of the present study was to examine both positive (i.e., shared friend support) and negative (i.e., disapproval and interference of partner’s friends) aspects of friend ties on divorce across 16 years. Using a sample of 355 Black and White couples from the Early Years of Marriage project, we examined these associations with a Cox proportional hazard regression, controlling for a number of demographic and relational factors. Our findings indicate that (1) the negative aspects of couples’ friend ties are more powerful predictors of divorce than positive aspects; (2) at least early in marriage, husbands’ negative perceptions of wives’ friends are more predictive of divorce than are wives’ negative perceptions of husbands’ friends; (3) friendship disapproval may be less critical in the marital lives of Black husbands and wives than of White husbands and wives; and (4) the association between disapproval of wives’ friends at Year 1 and divorce may be partially explained by wives’ friends interfering in the marriage. Our findings are interpreted in light of possible mechanisms to explain the link between partner disapproval of friends and divorce, such as diminished interdependence, less network approval, and increased spousal conflict and jealousy.
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Bakshi, Shinjini. "Peer Support as a Tool for Community Care: “Nothing About Us, Without Us”." Columbia Social Work Review 19, no. 1 (2021): 20–43. http://dx.doi.org/10.52214/cswr.v19i1.7602.
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In the face of socio-political marginalization, frontline communities reclaim power by harnessing peer wisdom and resilience. The year 2020 marked the confluence of a global pandemic and widespread resistance against anti-Black racism and police violence, highlighting the value of peer voices and community perspectives. To dismantle and transcend carceral approaches to community care, the field of social work is invited to join a larger anti-carceral mental health movement that honors lived experience and works alongside peers to build identity-affirming structures of mental health care. This article examines the ways in which frontline communities benefit from expanded access to anti-carceral formal and informal peer support as a mental health safety net that interrupts harm and prioritizes agency, consent, and self-determination. This paper broadens social work’s conceptualization of peer support through theoretical frameworks of anti-carceral social work, abolition, and intersectionality. Social work and its adjacent fields are called to urgently center Black liberation, collective healing, and community care by advocating for the integration of formal and informal peer support into mental health policy and practice. This paper strategically leans into a lineage of critical peer thought scholarship by utilizing footnotes and citations to model the ethical acknowledgment of peer labor within human rights movements. This intentional structure promotes radical solidarity that resists the exploitation of people with lived experience.
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Hlavackova, Alzbeta, Jan Vydra, Leona Chrastinova, et al. "Targeted Metabolomic Profiling in Acute Myeloid Leukemia with IDH2R140 and IDH2R172 Mutations." Blood 132, Supplement 1 (2018): 1470. http://dx.doi.org/10.1182/blood-2018-99-118245.
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Abstract Introduction Acute myeloid leukemia (AML) represents an aggressive bone marrow malignancy with diverse genetic abnormalities. The tumor cells, to support their own growth and proliferation, may alter metabolism 1) to accelerated glycolysis to provide energy/biosynthetic precursors and 2) to produce intermediates by active TCA cycle for synthesis of essential biomolecules [1]. Mutations of isocitrate dehydrogenase (IDH1/2) as frequent mutations (affecting approximately 20% of AML patients) cause the reduction of α-ketoglutarate to D-2-hydroxyglutarate instead of oxidative decarboxylation of isocitrate to α-ketoglutarate. IDH2 mutations occur almost exclusively in hematopoietic tumors. Whereas IDH2R140 mutation is frequently accompanied by normal cytogenetics and NPM1 mutations, IDH2R172 is frequently the only mutation detected in AML. In addition, IDH2R172 confers a poor prognosis in patients with AML [2, 3]. The aim of this study was to characterize and uncover the differences in metabolism of AML patients with or without IDH2 mutations in diagnosis (the initial stage), in remission (after chemotherapy treatment), and before transplantation (after conditioning). Methods Serum metabolomics profiles were generated with samples obtained at diagnosis, in remission, and before transplantation from patients (n=20) treated in the Institute of Hematology and Blood Transfusion, Prague, Czech Republic. Patients were assigned in IDH2WT (n=7) and IDH2R140/ IDH2R172 (n=7/6) groups. Targeted metabolomic profiling of 19 metabolites related mainly to TCA cycle and glycolysis was performed by LC-MS/MS. Results Using non-parametric randomized block analysis of variance (Friedman test) we found significant differences in levels of 13 metabolites among treatment periods for all AML patients. Moreover, when comparing each treatment periods for all patients, we found significantly decreasing levels of 12 metabolites between the initial stage and the period before transplantation. If we considered the division of patients into groups according to IDH2 mutations, we found significantly different levels of 4 metabolites among treatment periods for samples of patients with IDH2R140,namely 2 metabolites of TCA cycle: isocitrate, succinate; and 3-hydroxybutyrate and urate. We obtained significantly different levels in the same number of other metabolites for IDH2WT. In samples of patients with IDH2R172 we found significantly different levels of 8 metabolites among treatment periods, namely 5 metabolites of TCA cycle: citrate, 2-hydroxyglutarate, succinate, fumarate, malate; 2 metabolites of glycolysis: 3-phosphoglycerate, phosphoenolpyruvate; and pyroglutamate of glutathione metabolism. Furthermore, using Nemenyi post-hoc test we ascertained significantly decreasing levels of named metabolites in IDH2R140 and IDH2R172 samples before transplantation with respect to the initial stages of AML (diagnosis). Conclusion Overall, this study identified significant changes in several metabolites of TCA cycle and glycolysis between initial and final treatment periods and also between remission and period before transplantation in AML patients. With respect to IDH2 mutations we found more significant changes in metabolites specifically in TCA cycle for IDH2R172 patients relative to IDH2R140. The results of our preliminary targeted metabolomic profiling of AML patients with IDH2 mutations are corresponding with the already described differences in morphological and genetic patterns in the patients and, moreover, support the classification of IDH2R172 as separate AML subtype. Metabolomic profiling thus seems to be a new valuable tool providing additional important information. Acknowledgment This work was supported by the European Regional Development Fund and the state budget of the Czech Republic (project AIIHHP: CZ.02.1.01/0.0/0.0/16_025/0007428, OP RDE, Ministry of Education, Youth and Sports), by the project of the Ministry of Health, Czech Republic, 00023736, by Grant from the Academy of Sciences, Czech Republic, P205/12/G118, and by ERDF OPPK CZ.2.16/3.1.00/24001. [1] DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. Cell Metab. 2008;7(1):11-20. [2] Rakheja D, Konoplev S, Medeiros LJ, Chen W. Hum Pathol. 2012;43(10):1541-51. [3] Meggendorfer M, Cappelli LV, Walter W, Haferlach C, Kern W, Falini B, Haferlach T. Leukemia. 2018;32(5):1249-1253. Disclosures No relevant conflicts of interest to declare.
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Peterson, Dale E. "Justifying the Margin: The Construction of “Soul” in Russian and African-American Texts." Slavic Review 51, no. 4 (1992): 749–57. http://dx.doi.org/10.2307/2500135.
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The scholarly world has little noted nor long remembered the interesting fact that the emancipation proclamation of a culturally separate African-American literature was accompanied by a generous acknowledgment of Russian precedent. In 1925 Alain Locke issued the first manifesto of the modern Black Arts movement, The New Negro. There could not have been a clearer call for the free expression of a suppressed native voice: “we have lately had an art that was stiltedly selfconscious, and racially rhetorical rather than racially expressive. Our poets have now stopped speaking for the Negro—they speak as Negroes.“ Even so, this liberating word of the Harlem Renaissance was uttered with a sideward glance at the prior success of nineteenth century Russia's soulful literature and music. Locke himself cited the testimony of his brilliant contemporary, the author of Cane, a poetic distillation of the pungent essence of slavery's culture of oppression: “for vital originality of substance, the young Negro writers dig deep into the racy peasant undersoil of the race life.
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Krigsfeld, Gabriel, Aleeza Roth, Maureen Cooper, et al. "Observational Study of Tissue Acquisition Turnaround Time for Commercial Comprehensive Genomic Profiling in Solid Tumors." American Journal of Clinical Pathology 152, Supplement_1 (2019): S145—S146. http://dx.doi.org/10.1093/ajcp/aqz130.009.
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Abstract Introduction Increased development and use of next-generation sequencing in clinical diagnostics has revolutionized precision medicine. Steps prior to a specimen arriving at a diagnostic facility, including pathological evaluation, are crucial parameters determining specimen quality and success of comprehensive genomic profiling (CGP). This observational study identified factors that may influence tissue acquisition for commercial CGP in clinical oncology. Methods Data were collected from deidentified patients (n = 63) from select US pathology labs enrolled in a Foundation Medicine (FMI) early access program for the CGP test FoundationOne CDx (Foundation Medicine). A representative substudy cohort (n = 20) with qualitative information available was selected. Lab visit frequency by FMI was monitored for 42 cases. Tissue acquisition turnaround time (TA-TAT) was separated into stages: (1) tissue request to pathology lab acknowledgment, (2) pathology lab acknowledgment to tissue pathology review, (3) tissue pathology review to packaging, and (4) packaging to tissue arriving at FMI. Results Median TA-TAT for the total population was 5.0 days (range, 0-27.0) and 3.5 days for the substudy cohort (range, 1.0-11.0). The duration of each TA-TAT stage was evaluated separately and varied between labs (0%-71.4% of total TA-TAT). TA-TAT was longer for unstained slides compared with formalin-fixed, paraffin-embedded (FFPE) tissue blocks. There was a trend for decreased TA-TAT when stages 1 and 2 occurred on the same day versus different days. For the cases with lab-visit frequency reported, those with biweekly visits had shorter TA-TAT (biweekly: n = 12, median = 2.0, 2.5th-97.5th percentile range, 0.3-5.7 days; single visit: n = 30, median = 5.5, 2.5th-97.5th percentile range, 0.7-13.1 days). Conclusions Understanding and optimizing the tissue acquisition workflow may reduce TA-TAT, thereby facilitating report delivery and subsequent treatment guidance to patients. Funding Bristol-Myers Squibb. Professional medical writing and editorial assistance was provided by Katerina Pipili, PhD, and Jay Rathi, MA, of Spark Medica Inc, funded by Bristol-Myers Squibb.
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Kotlin, Roman, Ondrej Pastva, Jaromir Novak, et al. "Two Cases of Dysfibrinogenemia in Childhood." Blood 124, no. 21 (2014): 5066. http://dx.doi.org/10.1182/blood.v124.21.5066.5066.
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Abstract Introduction Hemostasis in childhood differs from that of adults; and the hemostatic system is still developing during childhood. These differences offer a protective advantage to children with hemorrhagic and thrombotic complications. Plasma levels of coagulation factors (except for fibrinogen, factor V and factor VIII), as well as plasma levels of protein C, protein S and antithrombin are reduced. Hereditary dysfibrinogenemia is a rare disorder wherein an inherited abnormality in fibrinogen structure may result in defective fibrin function and/or structure. Clinical symptoms may vary from asymptomatic to life-threatening bleeding complications. Venous or arterial thrombotic complications occur extremely rarely during childhood. Fibrinogen, a key component in hemostasis, is a 340-kDa glycoprotein. The molecule consists of three different pairs of polypeptide chains (Aα, Bβ, and γ) each encoded by a distinct gene (FGA, FGB, and FGG). N-terminal parts of the Aα chain - fibrinopeptides A and the Bβ chain - fibrinopeptides B are situated in the central part of the molecule and block polymerization of the molecules. Conversion of fibrinogen to fibrin occurs after the cleavage of N-terminal fibrinopeptides by the serine protease thrombin. Correct conformation of fibrinopeptides is important for the cleavage by thrombin. Methods Routine coagulation tests were performed with citrated plasma samples on a STA-R coagulation analyzer. The functional fibrinogen level was measured by the Clauss method. Total fibrinogen level was determined by an immunoturbidimetric assay performed on a UV-2401PC spectrophotometer. Fibrin polymerization induced by either thrombin or reptilase and fibrinolysis experiments were obtained by the turbidimetrical method. Fibrinopeptide release was measured as a function of time; and the fibrinopeptides were determined by the reversed-phase, high-performance liquid chromatography (RP-HPLC) method. The purified genomic DNA was amplified by polymerase chain reaction, using specific primers; and dideoxysequencing was performed with Dye Terminator Cycle Sequencing with a Quick Start kit and a CEQ 8000 genetic analysis system). Results We have examined two unrelated boys aged 4 (boy 1) and 14 (boy 2) for susp. dysfibrinogenemia. Routine coagulation tests revealed prolonged thrombin and reptilase time in both boys and also showed decreased functional fibrinogen levels in both kids (Tab. 1). Boy 1 presented with bleeding manifestation – easy bruising, epistaxis, and bleeding after tooth extraction. His 26-year-old mother presented with similar coagulation findings and with mild bleeding complications. Boy 2 was asymptomatic. Fibrin polymerization experiments carried out on plasma samples showed prolonged lag time and significantly reduced final turbidity in both cases. Measurement of kinetics of fibrinopeptide release showed a decreased amount of the released fibrinopeptide A in both patients. DNA sequencing of boy 1 revealed a point mutation in exon 2 of the FGA gene at the position 3456 G/A, which causes the substitution of Aα 16 Arg to His (fibrinogen Praha V). The boy was found to be heterozygous for the mutation as well as his mother. DNA analysis of boy 2 revealed the same point mutation in the FGAgene, causing the same substitution of Aα 16 Arg to His (fibrinogen Kralupy nad Vltavou). Conclusion In this study we report two cases of congenital defects in the fibrinogen Aα Arg16-Gly17 bond found during childhood. It has been described earlier that the replacement of Aα 16 arginine by histidine decelerates thrombin catalyzed fibrinopeptide A release. Although both kids presented with the same genetic defect and with similar coagulation results, they have different clinical manifestation of the disease. Acknowledgment This work was supported by the project of the Ministry of Health of the Czech Republic for conceptual development of the research organization 00023736, by Grant from the Academy of Sciences, Czech Republic (P205/12/G118), and by ERDF OPPK CZ.2.16/3.1.00/28007. Table 1: Routine coagulation test results Boy 1 Boy 1's mother Boy 2 Normal APTT 40.1 s 34.6 s 35.3 s 27.5 - 36.1 s Prothrombin time 17.5 s 14.4 s 16.9 s 11.7 - 15.1 s Thrombin time 40.9 s 36.2 s 44.8 s 17.6 - 21.6 s Reptilase time 58.3 s 51.6 s 55.7 s 16.0 - 20.0 s Fibrinogen (Clauss) 0.51 g/l 1.12 g/l 0.58 g/l 2.00 - 4.20 g/l Fibrinogen (Immuno) 2.47 g/l 2.68 g/l 2.31 g/l 2.00 - 4.20 g/l Age 4 26 14 - Disclosures No relevant conflicts of interest to declare.
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Boeva, Vasilisa, Yuri Voskoboinikov, and Rustam Mansurov. "Non-parametric identification of thermal control system elements." Analysis and data processing systems, no. 1 (March 26, 2021): 7–20. http://dx.doi.org/10.17212/2782-2001-2021-1-7-20.
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The thermal control system “Heater-Fan-Room” is represented by three different-type interconnected simpler subsystems. In this paper, a “black-box” whose structure is not specified is used as a mathematical model of the system and subsystems due to complexity of physical processes proceeding in these subsystems. For stationary linear systems, the connection between an input and an output of the “black-box” is defined by the Volterra integral equation of the first kind with an undetermined difference kernel also known as impulse response in the automatic control theory. In such a case, it is necessary to evaluate an unknown impulse response to use the “black-box” model and formulate all subsystems and the system as a whole. This condition complicates significantly the solution search of non-parametric identification problems in the system because an output of one subsystem is an input of another subsystem, so active identification schemes are unappropriated. Formally, an impulse response evaluation is a solution of the integral equation of the first kind for its kernel by registered noise-contaminated discrete input and output values. This problem is ill-posed because of the possible solution instability (impulse response evaluation in this case) relative to measurement noises in initial data. To find a unique stable solution regularizing algorithms are used, but the specificity of the impulse response identification experiment in the “Heater-Fan-Room” system do not allow applying computational methods of these algorithms (a system of linear equations or discrete Fourier transformation). In this paper, the authors propose two specific identification algorithms for complex technical systems. In these algorithms, impulse responses are evaluated using first derivatives of identified system signals that are stably calculated by smoothing cubic splines with an original smoothing parameter algorithm. The results of the complex “Heater-Fan-Room” system modeling and identification prove the efficiency of the algorithms proposed. Acknowledgments: The reported study was funded by RFBR, project number 20-38-90041.
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Parisi, Sarah, Stefania Paolini, Ilaria Iacobucci, et al. "Pediatric-Like Intensified Therapy In Adult Acute Lymphoblastic Leukemia: A Single Centre Experience." Blood 118, no. 21 (2011): 4261. http://dx.doi.org/10.1182/blood.v118.21.4261.4261.
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Abstract Abstract 4261 Background Acute lymphoblastic leukemia (ALL) shows different outcome in children and adults, with event-free-survival (EFS) rates of 70–80% and 30–40% at 5 years, respectively. Results improved in young adults/adolescents with de novo ALL, when treated with pediatric intensive regimens rather than with adult regimens. Clinical studies are ongoing in older patients, toxicity related-therapy seeming the limiting issue. Aims We report a single centre experience on adult ALL patients treated with an intensive pediatric-inspired schedule, aiming to assess its tolerability and efficacy. Methods From 11/07 to 03/11 we treated 24 ALL patients (M/F=17/7) according to modified AIEOP-LAL2000 regimen. Treatment consisted of 7 days steroid pre-treatment, and four drugs 78-days induction (phase IA and IB) after which high risk (HR) patients were treated with three polychemotherapy blocks, while intermediate (IR) and standard risk (SR) patients went on 8-weeks consolidation and subsequent intensification. A 2 cycle consolidation therapy with nelarabine was planned for T-ALL patients. Patients with HLA-matched donor underwent allo-SCT; 2-years maintenance therapy was given to the others. Median age was 30 years (17–47). Results 22/24 patients completed the phase IA, 2 being out for grade IV toxicity (intestinal occlusion and sepsis). 17 (70.8%) obtained a complete remission (CR), 5 (21%) were refractory. One of the resistant patients achieved CR after polychemotherapy blocks, two after phase IB. Median induction duration (IA+IB) was 95 days (82–136); delays were mostly experienced after phase IB, hematologic toxicity being an important cause of delay, with median time to neutrophil count recovery of 28 days (18–34) and 39 days (16–62) for phase IA and IB respectively. A higher absolute number of adverse events during phase IA than during IB was registered (infections and gastrointestinal), without a significant prolongation of phase IA. After induction, 3 of the 19 CR patients received consolidation therapy, then 2/3 underwent allo-SCT. 6 patients received blocks: 3/6 undewent allo-SCT, 2/6 dropped out after the first and the second block for reversible grade II-III renal toxicity and one relapsed. 5 patients were treated with nelarabine, then 2/5 underwent allo-SCT. 3/19 directly underwent allo-SCT, while 1 patient completed the whole therapeutic program because no suitable donors for allo-SCT were found. One patient died after phase IB for pulmonary infection. With a median follow up of 12 months (3–50), 14/24 (58,3%) patients are alive, 8 in CR (5 underwent allo-SCT). 10 patients died, 5 for relapsed/refractory disease, 5 in CR (3 after allo-SCT). Conclusions A pediatric-inspired therapeutic regimen demonstrated a significant hematologic and a subsequent infective toxicity in adult ALL patients, this causing a lack in dose-intensity maintenance. The overall outcome seemed to be comparable to the one reached in other studies conducted on larger population but a longer follow-up and a larger population are needed to draw definitive conclusions. Acknowledgments. BolognAIL, European LeukemiaNet, AIRC, Fondazione Del Monte di Bologna e Ravenna, FIRB 2006, PRIN 2008, Ateneo RFO, Project of Integrated Program (PIO), Programma di Ricerca Regione - Università 2007–2009. Disclosures: No relevant conflicts of interest to declare.
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Toledo, Dominique, Yanko Moreno, Octavio Peña, Ricardo Baggio та Andrés Vega. "New terpyridine-(β-diketonate)-copper(II) complex. Structure and magnetism". Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1262. http://dx.doi.org/10.1107/s2053273314087373.
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Over the last decade the design and synthesis of metal-organic compounds with fascinating structural properties and potential applications as functional materials has been a major challenge in various fields of research.1Strategies for preparing these compounds are based on the careful selection of the constituent building blocks. 4'-(substituted)-4,2':6',4''-terpyridine ligands are considered versatile building blocks for the assembly of coordination polymers and networks with useful solid-state properties, such as magnetism, luminescence, redox activity, etc.2The divergent arrangements of N-donor atoms and the attachment of aryl substituents into the 4'-position of 4,2':6',4''-terpyridine allow to bridge two or more metal centers, giving rise to molecular assemblies of 1, 2 or 3 dimensions.3Our line of interest is the obtainment of compounds with emergent magnetic properties. Herein we present a copper complex surveying the new 4'-(quinolin-4-yl)-4,2':6',4''-terpyridine ligand (L), and formulated as [Cu(C5H1F6O2)2(C25H16N4·CHCl3)]n which was produced from the reaction of two equivalents of L with Cu(hfac)2, (hfac=hexafluoroacetylacetonate). The copper ion in trans-{CuN2(hfac)2} has an octahedral environment. The nitrogen atoms of the terminal pyridine rings coordinate to the paramagnetic centres, while the central ring remains uncoordinated. The linkage of the resulting polyhedra gives raise to an undulating 1D polymeric structure. Within these chains there are two main non-covalent interactions: π-stacking between the quinoline substituents and the pyridine rings and CH···F interactions due to CF3group of the hfac ligand. There are also weak CH···N, CH···π and π-π intermolecular interactions linking the L and CHCl3groups, which give stability to the crystal structure. Finally, we performed magnetic measurements, in order to determine the magnetic behaviour of our system. Acknowledgments: FONDECYT 1130433 project, CIPA of University of Concepción, LIA-MIF 836
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Landman, Christina. "Women Flying with God: Allan Boesak’s Contribution to the Liberation of Women of Faith in South Africa." Studia Historiae Ecclesiasticae 43, no. 1 (2017): 166–77. http://dx.doi.org/10.25159/2412-4265/2720.
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In 2005 Allan Boesak published a book entitled Die Vlug van Gods Verbeelding (“The Flight of God’s Imagination”). It contains six Bible studies on women in the Bible, who are Hagar, Tamar, Rizpah, the Syrophoenician woman, the Samaritan woman as well as Martha and Mary, the sisters of Lazarus. This article argues that women of faith in South Africa have, throughout the ages, in religious literature been stylised according to six depictions, and that Boesak has, in the said book, undermined these enslaving depictions skilfully. The six historical presentations deconstructed by Boesak through the Bible studies are the following: 1) Women are worthy only in their usefulness to church and family without agency of their own; 2) A good woman is submissive on all levels, privately and publicly; 3) Women should sacrifice themselves to the mission of the church, without acknowledgment that they themselves are victims of patriarchy; 4) A good white woman is one that is loyal to the nation and to her husband while black women are to reject their cultures; 5) Women’s piety is restricted to dealing with their personal sins, while they are not to express their piety in public; 6) Women are forbidden by the Bible to participate in ordained religion.After references to these discourses in Christian literature of the past 200 years, the contents of Boesak’s Bible studies will be analysed to determine how—and how far—he has moved from these traditional views of women of faith. Finally the research findings will be summarised in a conclusion.
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Petropavlovskiy, M. V., I. M. Donnik, and N. A. Bezborodova. "EPIZOOTOLOGICAL AND PHYLOGENETIC EVALUATION OF THE BOVINE LEUKEMIA VIRUS IN RUSSIAN FEDERATION." Innovations and Food Safety, no. 3 (September 28, 2018): 161–65. http://dx.doi.org/10.31677/2311-0651-2018-0-3-161-165.
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The genetic characterization of BLV is an important task in scientific research in many countries of the world. According to the sequenced gene region - env BLV isolates allocated in different geographical locations of the world, up to 10 different genetic groups of the virus were identified and classified. Acknowledgments: The research was carried out at the expense of the Russian Science Foundation grant (project No. 17-76-10051). As part of the research, we monitored the epizootic situation of the BLV in Russia. Groups of animals (n=50) Holstein-Frisian (imported breed) and Russian Black Pied (local breed) were selected, belonging to agricultural organizations of the Tyumen region. Serological screening methods (ELISA, AGID) were used in cattle to identify infected animals. Immunological evaluation of animals in all test groups is given. A primary A nested-PCR study was performed, which resulted in a fragment of the env 444 bp gene in the studied samples. RFLP analysis of this fragment allowed to establish that in 94 % of the samples there was a «Belgian type» of the leukemia virus, in 4 % of samples - «Australian» and in 2 % - a «mixed type». All samples were sent for NGS sequencing. By phylogenetic evaluation of the BLV genome env site in the isolated samples and the immunological evaluation of the infected animals, new data will be obtained that will allow updating information on the genetic groups of the BLV in the territory of the Russian Federation.
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Kazarovets, N. V., T. V. Pavlova, and K. A. Moiseev. "Monitoring of production use of cows in dairy herd conditions with highly productive breeding livestock." Proceedings of the National Academy of Sciences of Belarus. Agrarian Series 57, no. 2 (2019): 204–15. http://dx.doi.org/10.29235/1817-7204-2019-57-2-204-215.
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Over the past decades, in many countries with developed dairy cattle breeding milk yield per cow per lactation has significantly increased, and period of cow productive use has been significantly reduced. The average duration of cow use in many countries is 2.5–2.8 lactations, and this is not enough for sustainable implementation of genetic potential of animals, which is revealed only at the 5–6th lactations. There is an increase in milk productivity and improvement of exterior type of black-and-white breed of cows in the Republic of Belarus, which is due to the use of Holstein cattle with outstanding milk productivity potential and a well-defined milk exterior type, however, as in other countries, there is a decrease in cow use period. The paper presents the results of monitoring of production use of cows in dairy herd conditions with highly productive breeding livestock. 5670 Holsteinized cows of Belarusian black-and-white breed were evaluated in two herds. The main causes of cows culling are determined, effect of genetic (blood level of Holstein breed, level of fathers and mothers performance) and paratypic (age of the 1st calving, level of heifers milking, inter-calving period, service period, results of the first insemination) factors for the life-long milk performance and cow use period. Correlation and heritability of indicators of productive longevity of cows is determined. A system of arrangement and breeding measures to improve longevity of highly productive livestock has been developed. Implementation of the developed system will allow to improve the integrated indices of breeding value of bulls and dairy cows and increase profitability of milk production by increasing the period of use of dairy herd maternal livestock. Acknowledgments. The work was carried out as part of the state research and technical program “Agropromcomplex – sustainable development” for 2011–2015 sub-task 3.3.1 on topic “Develop system of breeding work with maternal livestock of Holsteinized dairy herds of different productivity levels”.
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Gillman, Susan. "Micheaux's Chesnutt." PMLA/Publications of the Modern Language Association of America 114, no. 5 (1999): 1080–88. http://dx.doi.org/10.2307/463467.
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Who is, or are, Micheaux's Chesnutt(s)? Which of Charles Chesnutt's post-Reconstruction novels may Oscar Micheaux be said to have adapted in his films? To such seemingly obvious questions, there are some obvious answers. It is well known that Micheaux directed two film versions of Chesnutt's tragic novel of racial passing, The House behind the Cedars (1900): the first, in 1924, is entitled House behind the Cedars and is a faithful adaption that encountered difficulties with the censors; the second is the recently rediscovered Veiled Aristocrats (1932), a remake with a happy ending. It is less well known that around the same time, Micheaux may also have arranged to purchase the rights to Chesnutt's Marrow of Tradition (1901), a novel on the 1898 Wilmington, North Carolina, race “riot,” with a parallel plot on the struggles in an interracial family over the legitimacy of the mulatto side. It is not clear whether the transaction was ever completed or whether the Marrow film was ever made. But together the two novels may be said to map the conflicting contours of and historical changes in representations of racial passing—not only Chesnutt's but also Micheaux's. Both novelist and filmmaker chart the crossing of the classic passing plot of discovery and subsequent acknowledgment or denial of “black blood,” which shapes both Chesnutt's and Micheaux's House behind the Cedars, with narratives of legitimacy—legal, social, and professional—central to Marrow of Tradition. In the process, the novel and the film suggest how the traditional tropes of racial uplift that undergird the search for middle-class respectability, in a kind of updated passing plot, should be thought of as an available narrative form rather than a coherent ideology.
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Manu and Dr. Abha Shukla Kaushik. "Existential Dilemma in Toni Morrison’s Beloved." Creative Launcher 6, no. 3 (2021): 110–17. http://dx.doi.org/10.53032/tcl.2021.6.3.22.
Full textAbstract:
Toni Morrison verbalizes in novel manners the pain and battle of a traumatized self and local area. In her novels, the traumatic truth of a dark self shows itself in the characters' self-hatred and self-disdain, and in the deficiency of their individual and cultural identity. Her fiction resolves issues of African American history, traumatizing experience and identity, often additionally captivating with inquiries of sex and sex, and, less significantly, class. When writing in a climate where everything except a couple of dark writers battled for acknowledgment, presently the subject of much recognition, Morrison’s work has provoked various and assorted basic reactions. The Beloved and Song of Solomon utilize the devices of disruption, corruption and sensuality to portray the traumatic encounters of the Black ladies’ heroes. During the last fifteen or so years grant treating the Morrison oeuvre has blossomed, making her clearly quite possibly the most talked about creators of the contemporary time frame. Toni Morrison’s In her novel, Beloved (1987), Toni Morrison shows the overwhelming impacts of slavery and its specialist disasters as these impacts show themselves through numerous ages of one family. The trauma of slavery is with the end goal that nobody contacted by it can break liberated from the past, even a long time after actual freedom. This is valid for the novel's hero, Sethe, a once in the past oppressed lady living in Cincinnati after the Civil War and third novel Song of Solomon (1977) goes about as a milestone in her profession, since it uncovers the imaginative development she has acquired, and furthermore presents the arrangement she has observed to tackle the overwhelming issues she depicts in her initially traumatizing novel. The distinctive traumatic occasions make Morrison's novels appropriate for logo helpful perusing and examination.
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Alijantabar aghouzi, Samaneh. "Study on ammonia nitrogen and phosphorus removal using sequencing batch reactor." Science Proceedings Series 1, no. 2 (2019): 97–99. http://dx.doi.org/10.31580/sps.v1i2.690.
Full textAbstract:
Study on ammonia nitrogen and phosphorus removal using sequencing batch reactor
 Samaneh Alijantabar Aghouzi *
 Department of Chemical and Environmental Engineering, Faculty of Engineering
 Universiti Putra Malaysia, Serdang
 Malaysia
 
 Thomas S. Y. Choong 
 Sustainable Process Engineering Research Center (SPERC)
 Universiti Putra Malaysia, Serdang
 Malaysia
 
 Aida Isma M. I.
 Centre for Water Research, Faculty of Engineering and the Built Environment
 SEGi University, Kota Damansara
 Malaysia
 
 *Corrosponding author’s Email:
 sam.alijani@gmail.com
 
 
 
 
 
 
 
 
 
 Peer-review under responsibility of 3rd Asia International Multidisciplanry Conference 2019 editorial board
 (http://www.utm.my/asia/our-team/)
 © 2019 Published by Readers Insight Publisher,
 lat 306 Savoy Residencia, Block 3 F11/1,44000 Islamabad. Pakistan,
 info@readersinsight.net
 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
 
 
 _________________________________________________________
 
 Research Highlights
 
 
 The highest phosphorus and ammonia nitrogen removal efficiencies were 99.5% and 51%, respectively, in 6 hours.
 Particle size of sludge reduced from 26 μm to 39.81 μm in 60 days.
 Fourier transform infrared spectroscopy (FTIR) showed that N-O, N–H, S=O and C=N compunds detected.
 
 ___________________________________________________________________________
 
 Research Objectives
 
 Ammonia nitrogen and phosphorus removal have becoming more rigorous in permits making it one of the most important and most difficult processes to maintain in wastewater treatment plants. Sequencing batch reactor is a controlled activated sludge process that is able to tackle ammonia nitrogen and phosphorus issues and has some benefits such as having a small-scale system and low construction cost (1). The main goal of this research is to investigate the ability of SBR in treating sewage containing phosphorus and ammonia nitrogen in 6 hours to achieve the allowable effluent discharge standard set by the Department of Environment Malaysia.
 
 
 Materials and Methods
 
 In this experiment, a sequencing batch reactor with a total volume of 7 L. The mechanical stirrer was used to avoid sludge settling with a speed of 100 rpm. A fine bubble diffuser was used to supply air. The operation time was controlled based on 1 h and 30 mins anaerobic, 2 h and 10 mins anoxic, 1 h and 50 mins aerobic, making the hydraulic retention time (HRT) of 6 hours. 10 L seed sludge and 30 L raw sewage samples were collected weekly from the sewage treatment plant that was located in Selangor and were kept under 4oC in cold room in order to obtain fresh samples. The sludge volume was 30% of raw sewage volume in the reactor and the reactor refilled with 3.5 liters of raw sewage at the start point of the experiment. The experiment was carried out in room temperature of 27±3 oC with the pH value ranging from 6 to 8 and dissolve oxygen value ranging from 0 to 6 mg/L. Phosphorus and ammonia nitrogen were measured according to the APHA method (2). DO and PH were measured by using DO meter (JPB-70A) and PH meter (CT-6821, Shenzhen Kedida Electronic CO).
 
 
 Results
 
 The highest ammonia nitrogen removal efficiencies observed to be 31.9 %, 10.3 % and 38.8 % at the respective phases of anaerobic, anoxic and aerobic, respectively. Results showed that the phosphorus removal efficiencies for anaerobic, anoxic and aerobic phases were 70.43 %, 19.16%, and 98.58%, respectively in 6 hours. The highest phosphorus removal efficiency recorded was 98.58% that took place in the aerobic phase because of the absence of sufficient nitrate which can inhibit phosphorus uptake during the aerobic phase. The most sensitive process is nitrification that helps to biological oxidation of ammonia to nitrate, which is performed by two types of microorganisms, i.e. ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) (3). Karl et al. claimed that toxic substances inhibit the metabolism of bacteria (4). Mino et al. (5) also stated that nitrification process will not be accomplished in anaerobic phase without the presence of nitrate. This will affect the phosphorus uptake in the aeration phase.
 
 Findings
 
 FTIR spectrum shows that N-O, N–H, S=O and C=N compounds were identified in the sludge. The presence of these compounds might affect the nitrification and denitrification processes and indirectly affecting the degradation the ammonia nitrogen and phosphorus. Sewage sample might also contain heavy metals as the sewage treatment plant was located in the industrial area.
 
 
 Acknowledgment
 
 The authors gratefully thank the financial and research support of Universiti Putra Malaysia.
 
 References
 
 Sathian, S, M Rajasimman, C S Rathnasabapathy, and C Karthikeyan. 2014. “Journal of Water Process Engineering Performance Evaluation of SBR for the Treatment of Dyeing Wastewater by Simultaneous Biological and Adsorption Processes.†Journal of Water Process Engineering 4: 82–90.
 APHA. Standard Methods For the examination of water and Wastewater 23rd ed. ed. Washington, D.C.2017.
 Chang HN, Moon RK, Park BG, Lim S, Choi DW. Simulation of sequential batch reactor ( SBR ) operation for simultaneous removal of nitrogen and phosphorus. 2000;23.
 Karl DM, States U. Nitrogen Cycle ☆. 3rd ed. Encyclopedia of Ocean Sciences, 3rd Edition. Elsevier Inc.; 2018. 1-10 p.
 Mino T, Loosdrecht MCM van, Heijnen JJ. Microbiology and biochemistry of the EBPR process. Water Res. 1998;32(11):3193–207.
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Hadia, Nomery, Santiago Garcia-Granda, and Jose Garcia. "Nanocrystalline Oxides: CdS nanowires synthesized by solvothermal method." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1414. http://dx.doi.org/10.1107/s2053273314085854.
Full textAbstract:
Recent advances in the field of nanotechnology produced an assortment of one-dimensional (1D) structures, such as nanowires and nanorods. These fascinating materials are the potential building blocks for a wide range of nanoscale electronics, optoelectronics, magnetoelectronics, or sensing devices [1]. Parallel to the success with group IV and groups III–V compounds semiconductor nanostructures, semiconducting metal oxide materials with wide band gaps are attracting attention [2-3]. The main aim of this communication is to report our results on the application of several new techniques, particularly the use of hydrothermal synthesis, to fabricate single crystal one-dimensional nanostructured materials, study their growth processes, understand the growth mechanisms and investigate their physical properties. A wide range of remarkable features are then presented, to cover a number of metal oxides, such as ZnO, Sb2O3, CdS, MgO, α-Fe2O3, or TiO2, describing their structures, optical, magnetic, mechanical and chemical sensing properties. These studies constitute the basis for developing versatile applications based on metal oxide 1D systems as well as highlighting the current progress in device development. To exemplify, the as-prepared CdS nanowires have average 28 nm in diameter and length up to several micrometres. The direct band gap of the CdS nanowires is 2.56 eV calculated by the UV-vis absorption spectra. The PL spectrum has two distinct emission bands at 502 nm and 695 nm, which are associated with the near-band-edge emission and defect emission, respectively. These synthesized single-crystal CdS nanowires have a high potential in the optoelectronic applications of nanolasers, solar cells, lighting-emitting diodes or photodetectors. Acknowledgments: Erasmus Mundus MEDASTAR (Mediterranean Area for Science, Technology and Research) Programme, 2011–4051/002–001-EMA2, Spanish MINECO (MAT2010-15094, Factoría de Cristalización – Consolider Ingenio 2010) and ERDF.
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KASSEM, HADI SHAKEEB. "The Sixties in Berlin and in Hollywood: City with a Wall in Its Center—The Attempt to Erase the German Past." Advances in Politics and Economics 4, no. 3 (2021): p49. http://dx.doi.org/10.22158/ape.v4n3p49.
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Berlin was the location in which most of the intelligence operations in Europe have taken place in the first twenty years of the conquest and the Cold War. In November 27, 1958, Khrushchev issued a formal letter to the Allies, demanding that the western Allies evacuate Berlin and enable the establishment of an independent political unit, a free city. He threatened that if the West would not comply with this, the soviets would hand over to the East Germany’s government the control over the roads to Berlin. In the coming months Moscow conducted a war of nerves as the last date of the end of the ultimatum, May 27, 1959, came close. Finally the Soviets retreated as a result of the determination of the West. This event reconfirmed the claims of the West that “the US, Britain and France have legal rights to stay in Berlin.” According to Halle: “These rights derive from the fact that Germany surrendered as a result of our common struggle against Nazi Germany.” (Note 2) The Russians have done many attempts to change Berlin’s status. In 1961 Berlin Wall was constructed, almost without response on the part of the West, and by so doing, the Soviets perpetuated the status quo that had been since 1948. In July 25, 1961 Kennedy addressed the Americans on television, saying that “West Berlin is not as it had ever been, the location of the biggest test of the courage and the will power of the West.” (Note 3) On June 26, 1963, Kennedy went out to Berlin, which was divided by the wall, torn between east and west, in order to announce his message. In his speech outside the city council of West Berlin, Kennedy won the hearts of the Berliners as well as those of the world when he said: “Ich bin ein Berliner”, I’m a Berliner. The sixties were years of heating of the conflict with the Soviet Block. In 1961 the Berlin Wall was constructed. Then Kennedy came into power, there was the movement for human rights and the political tension between whites and blacks in America. The conflict increase as the Korean War started, and afterwards when America intervened in Vietnam. There was also the crisis in the Bay of Pigs in Cuba, which almost pushed the whole world into a nuclear war and catastrophe. During the 28 years of the Berlin Wall, 13.8.61-9.11.89, this was notorious as an example of a political border that marked the seclusion and freezing more than freedom of movement, communication and change. At the same time there was the most obvious sign of the division of Germany after WWII and the division of Europe to East and West by the Iron Curtain. The wall was the background of stories by writers from east and west. The writers of espionage thrillers were fascinated by the global conflict between east and west and the Cold War with Berlin as the setting of the divided city. Berlin presented a permanent conflict that was perceived as endless, or as Mews defined it: “Berlin is perfect, a romantic past, tragic present, secluded in the heart of East Germany.” (Note 4) The city presented the writers with a situation that demanded a reassessment of the genres and the ideological and aesthetic perceptions of this type of writing. This was the reason that the genre of espionage books blossomed in the sixties, mainly those with the wall. The wall was not just a symbol of a political failure, as East Germany could not stop the flow of people escaping from it. The city was ugly, dirty, and full of wires and lit by a yellow light, like a concentration camp. A West German policeman says: “If the Allies were not here, there would not have been a wall. He expressed the acknowledgment that the Western powers had also an interest in the wall as a tool for preventing the unification of Germany. But his colleague answers: If they were not here, the wall would not have been, but the same applies for Berlin. (Note 5) Berlin was the world capital of the Cold War. The wall threatened and created risks and was known as one of the big justifications for the mentality of the Cold War. The construction of the wall in August 1961 strengthened Berlin’s status as the frontline of the Cold War and as a political microcosmos, which reflected topographical as well as the ideological global struggle between east and west. It made Berlin a focus of interest, and this focus in turn caused an incentive for the espionage literature with the rise of neorealism with the anti-hero, as it also ended the era of romanticism. (Note 6) The works of le Carré and Deighton are the best examples of this change in literature. Both of them use the wall as the arena of events and a symbol in their works. Only at the end of the fifties, upon the final withdrawal of McCarthyism and the relative weakening of the Cold War, there started have to appear films with new images about the position and nature of the Germans and the representations of Nazism in the new history. The films of the Cold War presented the communists as enemies or saboteurs. Together with this view about the Soviets, developed the rehabilitation of the German image. Each part of the German society was rehabilitated and become a victim instead of an assistant of the Nazis. The critic Dwight MacDonald was impressed by the way in which the German population” has changed from a fearful assistant of one totalitarian regime to the hero opponent of another totalitarian regime”. (Note 7) This approach has to be examined, and how it influenced the development of the German representation, since many films I have investigated demonstrate a different approach of the German representation.
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Paolini, Stefania, Sarah Parisi, Ilaria Iacobucci, et al. "Pediatric Therapy In Adult Acute Lymphoblastic Leukemia: Updated Experience of a Single Centre." Blood 116, no. 21 (2010): 4338. http://dx.doi.org/10.1182/blood.v116.21.4338.4338.
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Abstract Abstract 4338 Background. Acute lymphoblastic leukemia (ALL) presents with different outcome in children and adults, with event-free-survival (EFS) rates of 70–80% and 30–40% at 5 years, respectively. This reflects both a different disease biology and different therapeutic approaches. Recently, results apparently improved in young adults/adolescents aged 15–21 years, with de novo ALL, when treated with pediatric intensive regimens rather than with typical adult regimens. Similarly, clinical studies are ongoing in older patients, toxicity related-therapy seeming the limiting issue. Aims. We report a single centre experience on adult ALL patients treated with an intensive pediatric-inspired schedule, designed to assess its tolerability and efficacy. Methods. From November 2007 to June 2010 seventeen ALL patients (M/F=12/5) were treated at our Center according to a modified AIEOP LAL2000 regimen. Treatment consisted of 7 days steroid pre-treatment, and four drugs 78-days induction (phase IA and phase IB) after which high risk (HR) patients were treated with three polychemotherapy blocks, while intermediate (IR) and standard risk (SR) patients went on 8-weeks consolidation and subsequent delayed intensification. Allo-SCT was planned for all patients with HLA-matched donor, as alternative to 2-years maintenance therapy. Median age was 31 years (range, 17–47). According to cytogenetic, response to steroid and minimal residual disease patients were classified into HR (n=7), IR (n=6) and SR (n=4). Results. 15/17 patients completed the induction phase IA, two being out for toxicity (grade IV infection and intestinal occlusion). Twelve (71%) obtained a complete remission (CR); three were refractory. However, one of them subsequently achieved CR after polychemotherapy blocks, for an overall response rate of 76% (13/17). Eleven patients then completed the 28-days induction IB. One patient is ongoing. Median induction duration was 92 days (range 82–136). Delays were mostly due to extra-hematological toxicity, the commonest being gastrointestinal (n=12), infective (n=7) and thrombotic (n=3). Delays were accumulated in both induction phases without significant difference between phase IA (median 18.5 days, range 4–37) and phase IB (median 17 days, range 9–66), despite an absolute number of moderate-severe AE superior in phase-IA versus phase-IB (12 vs 5). After induction, 4/12 patients already received consolidation therapy; 2/4 then received allo-SCT. The median duration of consolidation was 51 days (range 22–94). Conversely, 6/12 patients received polychemotherapy-blocks, one patient went directly on alloSCT and the remaining is ongoing. After polychemotherapy-blocks, five out six patients received allo-SCT. The median CR duration was 13 months (range 1+-42+); two patients relapsed, both after allo-SCT. With a median follow-up of 11 months (range 2–43) 11/17 (65%) patients are alive, 9 in CR (5 undergone allo-SCT). Six patients dead, three in CR for infectious complications, 3 for relapsed/refractory disease. Conclusions. Though in a small series, pediatric-like intensive chemotherapy seemed to be feasible in adult ALL. Extra-hematological toxicity, however, caused significant treatment delays during induction. Finally, the overall outcome appeared promising, though longer follow-up and larger populations are needed to draw definitive conclusions. Acknowledgments. BolognAIL, European LeukemiaNet, AIRC, Fondazione Del Monte di Bologna e Ravenna, FIRB 2006, PRIN 2008, Ateneo RFO, Project of Integrated Program (PIO), Programma di Ricerca Regione – Università 2007–2009. Disclosures: No relevant conflicts of interest to declare.
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Rudolph, Jennifer Domino. "Latining America: Black-Brown Passages and the Coloring of Latino/a Studies. By Claudia Milian. Athens: University of Georgia Press, 2013. Pp. 288. Acknowledgments. Notes. Works Cited. Index. $24.95 paper." Americas 72, no. 4 (2015): 684–86. http://dx.doi.org/10.1017/tam.2015.94.
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Govender, Karthy. "Oratio: Address to Commemorate the 2013 Martin Luther King Day at the Law Faculty, University of Michigan." Potchefstroom Electronic Law Journal/Potchefstroomse Elektroniese Regsblad 16, no. 3 (2017): 1. http://dx.doi.org/10.17159/1727-3781/2013/v16i3a2351.
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The paper commences by considering the similarity between Dr King, MK Gandhi and Nelson Mandela and argues that they are high mimetic figures who inspire us to be better. Their legacy and memory operate as a yardstick by which we can evaluate the conduct of those exercising public and private power over us. Each remains dominant in his respective society decades after passing on or leaving public life, and the paper suggests that very little societal value is had by deconstructing their lives and judging facets of their lives through the prism of latter day morality. We gain more by leaving their high mimetic status undisturbed. There is a clear link between their various struggles with King being heavily influenced by the writings and thinking of Gandhi, who commenced his career as a liberation activist in South Africa. King was instrumental in commencing the discourse on economic sanctions to force the Apartheid government to change and the Indian government had a long and committed relationship with the ANC. The second half of the paper turns to an analysis of how Dr King's legacy impacted directly and indirectly on developments in South Africa. One of the key objectives of the Civil Rights movement in the USA was to attain substantive equality and to improve the quality of life of all. The paper then turns to assessing the extent to which democratic South Africa has achieved these objectives and concludes that the picture is mixed. Important pioneering changes such as enabling gays and lesbians to marry have taught important lessons about taking rights seriously. However, despite important advancements, neither poverty nor inequality has been appreciably reduced. One of the major failures has been the inability to provide appropriate, effective and relevant education to African children in public schools. Effectively educating previously disadvantaged persons represents one of the few means at our disposal of reducing inequality and breaking the cycle of poverty. Fortunately, there is a general awareness in the country that something needs to be done about this crisis urgently. The paper notes comments by President Zuma that the level of wealth in white households is six times that of black households. The critique is that comments of this nature do not demonstrate an acknowledgment by the ANC that, after 19 years in power, they must also accept responsibility for statistics such as this.
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Wilson, M. E. "The Tribe of Black Ulysses: African American Lumber Workers in the Jim Crow South. By William P. Jones. Champaign: University of Illinois Press, 2005. xv + 235 pp. Illustrations, acknowledgments, notes, bibliography, index. Paper $20.00." Environmental History 12, no. 1 (2007): 159–60. http://dx.doi.org/10.1093/envhis/12.1.159.
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Alves, C., C. Figueiredo, A. Maurício, and L. Aires-Barros. "Salt weathering of limestones: susceptibility of petrographical features (SEM study)." Microscopy and Microanalysis 19, S4 (2013): 113–14. http://dx.doi.org/10.1017/s1431927613001189.
Full textAbstract:
Salt weathering is one of the main processes affecting rock materials applied in the built environment. Scanning electron microscopy (SEM) studies can contribute to the understanding of the susceptibility of petrographic features of rocks to salt weathering.SEM studies were performed in limestones (grainstones with the commercial designations of Semi-rijo and Moca Creme and a travertine) submitted to salt weathering tests (EN 12370 using sodium sulphate solutions and cubic specimens) consisting of 15 cycles of immersion/drying followed by water washing after the 15th cycle. Fragments from small cubes of the grainstones subjected to salt weathering cycles without the final water cleaning were also studied. SEM observation before and after the tests allows the discussion of the petrographical characteristics of these rocks that contribute to erosive decay under salt weathering.In the case of the grainstones specimens the texture can be described in general as allochemical particles cemented by sparry calcite (Figure 1 a) and it is visible from the preparation of the polished surfaces the interface between the sparry cement and the allochemical components. After the salt weathering tests, SEM studies show (Figure 1 b) extensive fissuring in the sparry cement and separation between grains and sparry cement. Observations of disaggregation products showed an important amount of apparently intact grains. These results are similar to those observed by with the sparry cement being affect by salt crystallisation and lesser impact on the grains. Studies in the unwashed specimens showed the presence of sodium sulphate in the interface between allochemical grains and the sparry cement (Figure 1 c,d). Travertine specimens show heterogeneous patterns of erosion attributed to the heterogeneous texture of this rock, with more terrigenous (especially clay-rich) portions that favour a higher erosive susceptibility and the presence of clays has been frequently connected with salt weathering susceptibility in limestones. In Figure 1e can be observed the heterogeneity of a polished surface, with the more irregular portions showing a chemical spectra (Figure 1 f) indicative of the terrigenous component and the presence of sodium and sulphate (resulting from the solutions used in these weathering tests).The authors acknowledge the support of the Fundação para a Ciência e Tecnologia (POCTI/CTA/44940/2002; PEst-OE/CTE/UI0697/2011 and Pest-OE/CTE/UI0098/2011, funding by the European Union and national budget of the Portuguese Republic). Acknowledgments to Eng. Teresa Luís, Eng. Sónia Pereira and Enterprise Mármores Galrão for the rock blocks.
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Milléo, Julianne, Felícia Pereira de Albuquerque, Jonathan Pena Castro, and Luciano de Azevedo Moura. "Descrição da larva de 3º ínstar e redescrição do adulto de Phaedon confinis Klug (Coleoptera: Chrysomelidae)." EntomoBrasilis 8, no. 2 (2015): 135–44. http://dx.doi.org/10.12741/ebrasilis.v8i2.452.
Full textAbstract:
Tendo em vista o potencial de Phaedon confinis Klug como biocontrolador de Senecio brasiliensis Less e a carência do conhecimento taxonômico das espécies de Phaedon registradas para o Brasil, o trabalho teve como objetivos descrever a larva de 3º instar, bem como acrescentar novos caracteres do adulto e ilustrações para o reconhecimento da espécie. As larvas de P. confinis são eruciformes, subcilíndricas, alongadas e ligeiramente convexas; superfície dorsal marrom-escura e ventral com regiões amareladas mais claras; quatro cerdas na fronte; seis estemas arranjados em três grupos; labro marrom, com quatro pares de cerdas; placa pronotal com dez cerdas; região pleural do protórax com tubérculo T; meso- e metatórax com tubérculos Dai e Dae aproximados, mas não fusionados, e tubérculos Es-Ss fusionados entre si e pela linha mediana; garras tarsais simples; abdômen com tubérculo Dae ausente e Dai presente e pouco pronunciado; tubérculos abdominais com duas cerdas em Dpi e Dpe. Adulto com corpo oval e convexo dorsalmente; pronoto e élitros glabros; coloração predominante azul violeta metálica; margens laterais do pronoto arredondadas, castanho-amareladas com mácula central azul-metálica; estrias elitrais com pontuações profundas e ordenadas em oito fileiras longitudinais; regiões castanho-amareladas na cabeça, protórax e pernas; cabeça com duas pequenas máculas pretas ovais, posteriores aos olhos na região do vértice.Description of the 3rd Instar Larva and Characters of Adult Phaedon confinis Klug (Coleoptera: Chrysomelidae)Abstract. In view of the potential of Phaedon confinis Klug as an biological control agent of the Senecio brasiliensis Less and the lack of taxonomic knowledge of the species Phaedon recorded for Brazil, this paper aimed to describe the 3rd larval instar, redescribe the adult, as well as add new characters and illustrations to acknowledgment of the specie. The P. confinis larvae are eruciform, subcylindrical, elongated and slightly convex; dorsal surface dark brown and ventral surface with yellowish lighter regions; four setae in the front; six stemmata arranged in three groups; brown labrum, with four pairs of setae, pronotal plate with ten setae; pleural region of prothorax with tubercle T; meso- and metathorax with tubercles Dai and Dae close, but not fused, and tubercles Es-Ss fused between themselves by midline; simple tarsal claws; abdomen with tubercle Dae absent and Dai present, little pronounced; abdominal tubercles with two setae in Dpi and Dpe. Adult has oval body and dorsally convex; pronotum and elytral glabrous; predominant colour blue metallic violet; lateral margins of pronotum rounded, yellowish brown with central macula metallic blue, elytral striae with deep punctuation and arranged in eight longitudinal rows; yellowish brown regions on the head, prothorax and legs; head with two small oval black maculae, posterior to the eyes in vertex region.
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Russo, Domenico, Giovanni Martinelli, Michele Malagola, et al. "One Year of Intermittent Imatinib (IM) Treatment (InterIM) Maintains the Complete Cytogenetic Response (CCgR) Previously Achieved with Standard IM Therapy In Elderly (≥ 65 years) Ph+ CML Patients – EudraCT Number 2007–005102-42, ClinicalTrials.Gov NCT 00858806." Blood 116, no. 21 (2010): 3412. http://dx.doi.org/10.1182/blood.v116.21.3412.3412.
Full textAbstract:
Abstract Abstract 3412 The phase II explorative study of intermittent Imatinib (IM) treatment (InterIM) in elderly patients with Ph + chronic myeloid Leukemia (CML) who achieved a stable complete cytogenetic response (CCgR) after at least 2-years standard IM therapy (any dose between 300 and 800 mg/day) was started in April 2008 and closed for the enrollment in August 2009, since more than 78 patients required by statistics were included into the study. The main objective of the study was to investigate if after 12 months (trial time) the CCgR achieved with standard (daily administration) IM therapy could be maintained with InterIM. For this purpose, the CgR status was assessed by Interphase Fluorescence In Situ Hybridization (I-FISH) on peripheral blood (≥ 200 cells counted) every 3 months. When I-FISH (% Ph + nuclei) increased more then 1%, chromosome banding analysis (CBA) on bone marrow was performed to confirm the loss of CCgR and to check for additional cytogenetic abnormalities (ACA). At the present time, out of the 95 patients who were enrolled, 82 patients were evaluable and out of them 77 (94%), 73 (89%), 71 (87%) and 70 (85%) completed 3, 6, 9 and 12 months of the treatment program, respectively. Therefore, the great majority of patients completed the study core and at the end of 2010 all the patients are expected to complete the trial time (12 mo). During the first 12 months of InterIM, 1% to 11% of the evaluable patients at 3, 6, 9 and 12 months showed an I-FISH >1% Ph+ nuclei (Figure 1). Figure 1 Distribution of patients according to I-FISH Figure 1. Distribution of patients according to I-FISH Totally, eleven (13%) out of 82 patients treated with InterIM showed an I-FISH >1% and they were checked by CBA on bone marrow (Figure 2). Out of them only 3 cases, that means 4% of the 82 evaluable patients, lost the CCgR and resumed standard IM therapy (daily administration), but none completed 3 months of therapy. All the patients lost the MMR and increased several folds the BCR-ABL transcript levels. Two pts had a low risk Sokal and one a high risk; age was 66, 69, 77 years; time from diagnosis was 29, 91 and 100 months; duration of IM therapy was 29, 83 and 84 months; the IM dose was 400mg in all cases. Figure 2 Cytogenetic and molecular response in 11 cases who showed I-FISH >1% + nuclei and who were checked by CBA on bone marrow. Black boxes shows the 3 cases who lost the CCgR Figure 2. Cytogenetic and molecular response in 11 cases who showed I-FISH >1% + nuclei and who were checked by CBA on bone marrow. Black boxes shows the 3 cases who lost the CCgR As concern as molecular response, 99% of the patients had a major molecular response (MMR=<0.001-0.1 BCR-ABL/ABLISX 100) at the baseline. The proportion of the patients who maintained the MMR after 3, 6, 9 and 12 months of InterIM was 95%, 92%, 91%, 84%, respectively. Interestingly, we found a weak but significant correlation between the % of BCR-ABL + nuclei and the BCR-ABL transcript levels in the patients who completed the trial time (12 mo) (r=0.27; p=0.001). In conclusion, the results of the InterIM study core (12 months), clearly show that Intermittent Imatinib (IM) treatment (InterIM) is sufficient to maintain the complete cytogenetic response (CCgR) previously achieved with standard IM therapy in elderly (≥ 65 years) Ph+ CML patients. The risk to loose the CCgR has been very low (4%), while the benefit either in terms of reduction of IM dose and of costs of therapy or in terms of compliance (data not shown) was very high. Acknowledgments: This work was supported in part by CML-Leukemia Net and Progetto Regione Lombardia. Disclosures: No relevant conflicts of interest to declare.