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Journal articles on the topic 'Blood-brain-barrier-on-a-chip'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Zhou, Shutong. "Blood-brain barrier on-a-chip and its application." Theoretical and Natural Science 8, no. 1 (2023): 290–95. http://dx.doi.org/10.54254/2753-8818/8/20240433.

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In the past five years, the organ-on-a-chip technology developed quickly and provided a novel platform for in vitro modelling and experimental testing. Blood-brain barrier (BBB) is an important barrier separating the brain from the rest of the body, thereby protecting the brain from toxins. It is important to study the BBB in terms of its permeability to various molecules, not only identifying potential toxins that might harm the brain, but also to design administration routes for drugs targeting the central nervous system (CNS). This review will summarize various recent designs of the BBB chi

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Deosarkar, Sudhir P., Balabhaskar Prabhakarpandian, Bin Wang, Joel B. Sheffield, Barbara Krynska, and Mohammad F. Kiani. "A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip." PLOS ONE 10, no. 11 (2015): e0142725. http://dx.doi.org/10.1371/journal.pone.0142725.

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Reshma, S., K. B. Megha, S. Amir, S. Rukhiya, and P. V. Mohanan. "Blood brain barrier-on-a-chip to model neurological diseases." Journal of Drug Delivery Science and Technology 80 (February 2023): 104174. http://dx.doi.org/10.1016/j.jddst.2023.104174.

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Periketi, Praneetha, Karmanjot Kaur, Faisal Naseer Vaid, et al. "Blood brain barrier-on-a-chip permeation to model neurological diseases using microfluidic biosensors." Journal of Knowledge Learning and Science Technology ISSN: 2959-6386 (online) 3, no. 4 (2024): 78–93. http://dx.doi.org/10.60087/jklst.v3.n4.p78.

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The need to understand human body functions, monitor disease progression, and advance in drug development have consistently been major driving forces for medical innovations and advancements. Organ-on-a-Chip technology, particularly Blood-brain-barrier (BBB)-on-chip technology, creates an avenue to closely replicate the brain environment and provides real-time monitoring of cells. Located at the interface between the blood and the brain parenchyma, the blood-brain barrier is crucial for protecting the brain due to its semi-permeable nature, and is responsible for regulating the movement of mol

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Phan, Duc TT, R. Hugh F. Bender, Jillian W. Andrejecsk, et al. "Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface." Experimental Biology and Medicine 242, no. 17 (2017): 1669–78. http://dx.doi.org/10.1177/1535370217694100.

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The blood–brain barrier is a dynamic and highly organized structure that strictly regulates the molecules allowed to cross the brain vasculature into the central nervous system. The blood–brain barrier pathology has been associated with a number of central nervous system diseases, including vascular malformations, stroke/vascular dementia, Alzheimer’s disease, multiple sclerosis, and various neurological tumors including glioblastoma multiforme. There is a compelling need for representative models of this critical interface. Current research relies heavily on animal models (mostly mice) or on

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Cui, Baofang, and Seung-Woo Cho. "Blood-brain barrier-on-a-chip for brain disease modeling and drug testing." BMB Reports 55, no. 5 (2022): 213–19. http://dx.doi.org/10.5483/bmbrep.2022.55.5.043.

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Liang, Yan, and Jeong-Yeol Yoon. "In situ sensors for blood-brain barrier (BBB) on a chip." Sensors and Actuators Reports 3 (November 2021): 100031. http://dx.doi.org/10.1016/j.snr.2021.100031.

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Staicu, Cristina Elena, Florin Jipa, Emanuel Axente, Mihai Radu, Beatrice Mihaela Radu, and Felix Sima. "Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations." Biomolecules 11, no. 6 (2021): 916. http://dx.doi.org/10.3390/biom11060916.

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Lab-on-a-chip (LOC) and organ-on-a-chip (OOC) devices are highly versatile platforms that enable miniaturization and advanced controlled laboratory functions (i.e., microfluidics, advanced optical or electrical recordings, high-throughput screening). The manufacturing advancements of LOCs/OOCs for biomedical applications and their current limitations are briefly discussed. Multiple studies have exploited the advantages of mimicking organs or tissues on a chip. Among these, we focused our attention on the brain-on-a-chip, blood–brain barrier (BBB)-on-a-chip, and neurovascular unit (NVU)-on-a-ch

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Ahn, Song Ih, and YongTae Kim. "Human Blood–Brain Barrier on a Chip: Featuring Unique Multicellular Cooperation in Pathophysiology." Trends in Biotechnology 39, no. 8 (2021): 749–52. http://dx.doi.org/10.1016/j.tibtech.2021.01.010.

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Thakkar, S., T. Fowke, A. Nicolas, A. L. Nair, M. Pontier, and N. Wevers. "LP-17 Blood-brain barrier on-a-chip to study compound-induced disruption." Toxicology Letters 368 (September 2022): S289—S290. http://dx.doi.org/10.1016/j.toxlet.2022.07.759.

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Wevers, N., T. Fowke, A. Nicolas, A. L. Nair, and M. Pontier. "OS04-05 Blood-brain barrier on-a-chip to study compound-induced disruption." Toxicology Letters 384 (September 2023): S71—S72. http://dx.doi.org/10.1016/s0378-4274(23)00441-1.

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12

Apu, Ehsanul Hoque, Huing li, Victor Zhao, et al. "Abstract 1322: Comparison of brain extracellular matrices in a blood brain barrier organ on a chip model." Cancer Research 83, no. 7_Supplement (2023): 1322. http://dx.doi.org/10.1158/1538-7445.am2023-1322.

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Abstract Recent advances in organ on a chip blood brain barriers (BBB) to study brain metastasis have revealed a critical understanding about the metastatic cascade. Most BBB models utilize collagen as brain parenchyma. While the exact role of the tumor microenvironment (TME) in brain metastasis is poorly understood, it has been observed to influence tumor growth. Therefore, the contents of this space must mimic the human brain composition. The extracellular matrix (ECM) occupies 10–20% of the brain volume to form its microenvironment (BME) and contains large quantities of hyaluronan/hyaluroni

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dePalma, Thomas, Kennedy Hughes, David Fraas, Marie Tawfik, Colin Hisey, and Aleksander Skardal. "MODL-35. BIOENGINEERED HYDROGEL AND BLOOD BRAIN BARRIER-ON-A-CHIP SYSTEM TO STUDY GLIAL CELL ACTIVATION AND BLOOD BRAIN BARRIER DYSFUNCTION IN GLIOBLASTOMA." Neuro-Oncology 25, Supplement_5 (2023): v306. http://dx.doi.org/10.1093/neuonc/noad179.1186.

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Abstract Treatments for glioblastoma (GBM) are limited leading to short patient life expectancies after diagnosis. Current preclinical models of GBM fail to accurately replicate the function of the blood brain barrier (BBB) and the extreme heterogeneity of the GBM tumor hindering the drug development process. Therefore, there is a pressing need for improved model systems to study how different GBM subpopulations interact with glial cells and the BBB. To build such a model, we first focused on designing a 3D extracellular matrix-based hydrogel biomaterial that would support human astrocytes and

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Brown, Jacquelyn A., Virginia Pensabene, Dmitry A. Markov, et al. "Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor." Biomicrofluidics 9, no. 5 (2015): 054124. http://dx.doi.org/10.1063/1.4934713.

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Alves, Arielly da Hora, Mariana Penteado Nucci, Nicole Mastandrea Ennes do Valle, et al. "Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip." World Journal of Stem Cells 15, no. 6 (2023): 632–53. http://dx.doi.org/10.4252/wjsc.v15.i6.632.

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Kim, Jin, Kyung-Tae Lee, Jong Seung Lee, et al. "Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier." Nature Biomedical Engineering 5, no. 8 (2021): 830–46. http://dx.doi.org/10.1038/s41551-021-00743-8.

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Yan, Li, Cole W. Dwiggins, Udit Gupta, and Kimberly M. Stroka. "A Rapid-Patterning 3D Vessel-on-Chip for Imaging and Quantitatively Analyzing Cell–Cell Junction Phenotypes." Bioengineering 10, no. 9 (2023): 1080. http://dx.doi.org/10.3390/bioengineering10091080.

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The blood-brain barrier (BBB) is a dynamic interface that regulates the molecular exchanges between the brain and peripheral blood. The permeability of the BBB is primarily regulated by the junction proteins on the brain endothelial cells. In vitro BBB models have shown great potential for the investigation of the mechanisms of physiological function, pathologies, and drug delivery in the brain. However, few studies have demonstrated the ability to monitor and evaluate the barrier integrity by quantitatively analyzing the junction presentation in 3D microvessels. This study aimed to fabricate

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Sood, Ankur, Anuj Kumar, Atul Dev, Vijai Kumar Gupta, and Sung Soo Han. "Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research." Pharmaceutics 14, no. 5 (2022): 993. http://dx.doi.org/10.3390/pharmaceutics14050993.

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The intrinsic architecture and complexity of the brain restricts the capacity of therapeutic molecules to reach their potential targets, thereby limiting therapeutic possibilities concerning neurological ailments and brain malignancy. As conventional models fail to recapitulate the complexity of the brain, progress in the field of microfluidics has facilitated the development of advanced in vitro platforms that could imitate the in vivo microenvironments and pathological features of the blood–brain barrier (BBB). It is highly desirous that developed in vitro BBB-on-chip models serve as a platf

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Lowman, John, Nienke Wevers, Xandor Spijkers, et al. "BBB-on-a-chip: A 3D In vitro model of the human blood-brain barrier." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S54. http://dx.doi.org/10.1016/j.dmpk.2018.09.191.

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A, agannath, and Pearson A. N. "The Future of OOC on Neurological Diseases - Alzheimer's." International Journal for Research in Applied Science and Engineering Technology 12, no. 10 (2024): 116–22. http://dx.doi.org/10.22214/ijraset.2024.64231.

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Abstract: Neurological Diseases such as Alzheimer's and Parkinsons' have been deemed incurable diseases. The complexity of the human brain is an obstacle for scientists to understand how treatments could interact with human brain microenvironments. To this date, researchers have used traditional modeling methods, such as in vitro cell culture and in vivo animal models. These methods are unable to showcase the different layers of the blood-brain barrier or accurately represent the cellular interactions within the brain. The proposed solution is a new research technology, organ on a chip, a mult

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Yu, Fang, Nivasini D/O Selva Kumar, Lynette C. Foo, Sum Huan Ng, Walter Hunziker, and Deepak Choudhury. "A pump‐free tricellular blood–brain barrier on‐a‐chip model to understand barrier property and evaluate drug response." Biotechnology and Bioengineering 117, no. 4 (2020): 1127–36. http://dx.doi.org/10.1002/bit.27260.

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Maes, L., S. Van Welden, R. Vandenbroucke, and D. Laukens. "P0131 Characterisation of a human multi-organ-on-chip model to unravel gut-blood-brain communication." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i516. https://doi.org/10.1093/ecco-jcc/jjae190.0305.

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Abstract Background Persistent fatigue is a frequently reported symptom among patients with Inflammatory Bowel Disease (IBD), significantly diminishing quality of life. Due to the lack of understanding how IBD-associated fatigue originates, currently available treatments do not efficiently tackle this symptom. Developing targeted therapies requires tools to unravel the mechanisms behind central nervous system dysfunction in response to chronic intestinal inflammation. We are therefore establishing and characterising a human multi-organ-on-chip model to recapitulate key physiological elements o

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Kincses, András, Judit P. Vigh, Dániel Petrovszki, et al. "The Use of Sensors in Blood-Brain Barrier-on-a-Chip Devices: Current Practice and Future Directions." Biosensors 13, no. 3 (2023): 357. http://dx.doi.org/10.3390/bios13030357.

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The application of lab-on-a-chip technologies in in vitro cell culturing swiftly resulted in improved models of human organs compared to static culture insert-based ones. These chip devices provide controlled cell culture environments to mimic physiological functions and properties. Models of the blood-brain barrier (BBB) especially profited from this advanced technological approach. The BBB represents the tightest endothelial barrier within the vasculature with high electric resistance and low passive permeability, providing a controlled interface between the circulation and the brain. The mu

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Choi, Jin-Ha, Mallesh Santhosh, and Jeong-Woo Choi. "In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device." Micromachines 11, no. 1 (2019): 21. http://dx.doi.org/10.3390/mi11010021.

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The blood–brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders, a critical type of human disease. Therefore, suitable in vitro BBB models with fluidic flow to mimic the shear stress and supply of nutrients have been developed. Neurological disorder has also been investigated for developing realistic models that allow advance fundamental and translational research and effective therapeutic strategy design. Here,

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Santa-Maria, Ana R., Fruzsina R. Walter, Ricardo Figueiredo, et al. "Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model." Journal of Cerebral Blood Flow & Metabolism 41, no. 9 (2021): 2201–15. http://dx.doi.org/10.1177/0271678x21992638.

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Microfluidic lab-on-a-chip (LOC) devices allow the study of blood-brain barrier (BBB) properties in dynamic conditions. We studied a BBB model, consisting of human endothelial cells derived from hematopoietic stem cells in co-culture with brain pericytes, in an LOC device to study fluid flow in the regulation of endothelial, BBB and glycocalyx-related genes and surface charge. The highly negatively charged endothelial surface glycocalyx functions as mechano-sensor detecting shear forces generated by blood flow on the luminal side of brain endothelial cells and contributes to the physical barri

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Ahn, Yujin, Ju-Hyun An, Hae-Jun Yang, et al. "Human Blood Vessel Organoids Penetrate Human Cerebral Organoids and Form a Vessel-Like System." Cells 10, no. 8 (2021): 2036. http://dx.doi.org/10.3390/cells10082036.

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Vascularization of tissues, organoids and organ-on-chip models has been attempted using endothelial cells. However, the cultured endothelial cells lack the capacity to interact with other somatic cell types, which is distinct from developing vascular cells in vivo. Recently, it was demonstrated that blood vessel organoids (BVOs) recreate the structure and functions of developing human blood vessels. However, the tissue-specific adaptability of BVOs had not been assessed in somatic tissues. Herein, we investigated whether BVOs infiltrate human cerebral organoids and form a blood–brain barrier.

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Perxés Perich, Marta, Sujey Palma-Florez, Clara Solé та ін. "Polyoxometalate-Decorated Gold Nanoparticles Inhibit β-Amyloid Aggregation and Cross the Blood–Brain Barrier in a µphysiological Model". Nanomaterials 13, № 19 (2023): 2697. http://dx.doi.org/10.3390/nano13192697.

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Alzheimer’s disease is characterized by a combination of several neuropathological hallmarks, such as extracellular aggregates of beta amyloid (Aβ). Numerous alternatives have been studied for inhibiting Aβ aggregation but, at this time, there are no effective treatments available. Here, we developed the tri-component nanohybrid system AuNPs@POM@PEG based on gold nanoparticles (AuNPs) covered with polyoxometalates (POMs) and polyethylene glycol (PEG). In this work, AuNPs@POM@PEG demonstrated the inhibition of the formation of amyloid fibrils, showing a 75% decrease in Aβ aggregation in vitro.

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Uzoechi, Samuel Chidiebere, Boyce Edwin Collins, Cody Joseph Badeaux та ін. "Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model". Applied Sciences 14, № 9 (2024): 3917. http://dx.doi.org/10.3390/app14093917.

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The disruption of the blood–brain barrier (BBB) in Alzheimer’s Disease (AD) is largely influenced by amyloid beta (Aβ). In this study, we developed a high-throughput microfluidic BBB model devoid of a physical membrane, featuring endothelial cells interacting with an extracellular matrix (ECM). This paper focuses on the impact of varying concentrations of Aβ1–42 oligomers on BBB dysfunction by treating them in the luminal. Our findings reveal a pronounced accumulation of Aβ1–42 oligomers at the BBB, resulting in the disruption of tight junctions and subsequent leakage evidenced by a barrier in

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Chim, Shek Man, Kristen Howell, Alexandros Kokkosis, Brian Zambrowicz, Katia Karalis, and Elias Pavlopoulos. "A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood–Brain Barrier Crossing Therapeutic Strategies." Pharmaceutics 16, no. 10 (2024): 1314. http://dx.doi.org/10.3390/pharmaceutics16101314.

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Background/Objectives: The limited translatability of preclinical experimental findings to patients remains an obstacle for successful treatment of brain diseases. Relevant models to elucidate mechanisms behind brain pathogenesis, including cell-specific contributions and cell-cell interactions, and support successful targeting and prediction of drug responses in humans are urgently needed, given the species differences in brain and blood-brain barrier (BBB) functions. Human microphysiological systems (MPS), such as Organ-Chips, are emerging as a promising approach to address these challenges.

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Iyer, Jayashree, Adam Akkad, Nanyun Tang, et al. "Abstract 195: A focused ultrasound blood brain barrier disruption model to test the influence of tight junction genes to treat brain tumors." Cancer Research 82, no. 12_Supplement (2022): 195. http://dx.doi.org/10.1158/1538-7445.am2022-195.

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Abstract A major hindrance to advances in the care of patients with malignant gliomas is the presence of the blood brain barrier (BBB) and blood-brain tumor barrier (BBTB) that greatly restricts drug access from the plasma to the tumor cells. Bubble-assisted Focused Ultrasound (BAFUS) has proven effective in opening the BBB for treatment of glial tumors in adults and pediatric cases. BAFUS has been previously shown to disrupt noninvasively, selectively, and transiently the BBB in small animals in vivo. However, there is a lack of an in vitro preclinical model suitable for testing the genetic d

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Lim, Jaejoon, Sujin Cho, Gaeun Lee, et al. "TMIC-47. HUMAN BLOOD-BRAIN TUMOR BARRIER ON A CHIP TO INVESTIGATE PERSONALIZED TREATMENT FOR GLIOBLASTOMA PATIENTS." Neuro-Oncology 26, Supplement_8 (2024): viii308—viii309. http://dx.doi.org/10.1093/neuonc/noae165.1225.

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Abstract The inherent characteristics of glioblastoma multiforme (GBM), including tumoral heterogeneity and invasive capacity, combined with the presence of the blood-brain tumor barrier (BBTB), present challenges in developing effective treatment for GBM. Especially, the margins of GBM, where GBM cells infiltrate normal brain tissue, exhibit high resistance to therapies. Despite the difficulties in controlling tumor progression from this region, the GBM margin remains a critical area to be studied. Here we report a microengineered model that mimics the BBTB within the GBM margin, incorporatin

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Taylor-Chilton, Ms Eleanor, Dr Lydia Baldwin, Dr Lucy Stead та ін. "APPLICATION OF IN VITRO MODELS: INCORPORATING BLOOD BRAIN BARRIER MODELS WITH GLIOMA, AND THE USE OF MICROﬂUIDICS". Neuro-Oncology 26, Supplement_7 (2024): vii7. http://dx.doi.org/10.1093/neuonc/noae158.025.

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Abstract AIMS The blood brain barrier (BBB) presents one of the main obstacles for the development of novel glioblastoma treatments. The various transporters and enzymes within the BBB reduce the disposition of novel therapies into the brain. There is a need for an in vitro BBB-glioma model with proven eﬃcacy of predicting CNS delivery at earlier stages in the drug discovery pipeline. METHOD A BBB-glioma lab-on-a-chip model could enable rapid identiﬁcation of novel therapies that can cross the BBB at earlier stages of the drug development process, before going to clinical trials. The applicati

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Mármol, Inés, Sara Abizanda-Campo, Jose M. Ayuso, Ignacio Ochoa, and Sara Oliván. "Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation." Bioengineering 10, no. 5 (2023): 572. http://dx.doi.org/10.3390/bioengineering10050572.

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Current available animal and in vitro cell-based models for studying brain-related pathologies and drug evaluation face several limitations since they are unable to reproduce the unique architecture and physiology of the human blood–brain barrier. Because of that, promising preclinical drug candidates often fail in clinical trials due to their inability to penetrate the blood–brain barrier (BBB). Therefore, novel models that allow us to successfully predict drug permeability through the BBB would accelerate the implementation of much-needed therapies for glioblastoma, Alzheimer’s disease, and

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Li, Yan, Yan Liu, Chuanlin Hu, et al. "Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip." Environment International 143 (October 2020): 105598. http://dx.doi.org/10.1016/j.envint.2020.105598.

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Noorani, Behnam, Aditya Bhalerao, Snehal Raut, Ehsan Nozohouri, Ulrich Bickel, and Luca Cucullo. "A Quasi-Physiological Microfluidic Blood-Brain Barrier Model for Brain Permeability Studies." Pharmaceutics 13, no. 9 (2021): 1474. http://dx.doi.org/10.3390/pharmaceutics13091474.

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Microfluidics-based organ-on-a-chip technology allows for developing a new class of in-vitro blood-brain barrier (BBB) models that recapitulate many hemodynamic and architectural features of the brain microvasculature not attainable with conventional two-dimensional platforms. Herein, we describe and validate a novel microfluidic BBB model that closely mimics the one in situ. Induced pluripotent stem cell (iPSC)-derived brain microvascular endothelial cells (BMECs) were juxtaposed with primary human pericytes and astrocytes in a co-culture to enable BBB-specific characteristics, such as low pa

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Jeong, Sehoon, Jae-Hyeong Seo, Kunal Sandip Garud, Sung Woo Park, and Moo-Yeon Lee. "Numerical approach-based simulation to predict cerebrovascular shear stress in a blood-brain barrier organ-on-a-chip." Biosensors and Bioelectronics 183 (July 2021): 113197. http://dx.doi.org/10.1016/j.bios.2021.113197.

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Tu, Kai-Hong, Ling-Shan Yu, Zong-Han Sie, et al. "Development of Real-Time Transendothelial Electrical Resistance Monitoring for an In Vitro Blood-Brain Barrier System." Micromachines 12, no. 1 (2020): 37. http://dx.doi.org/10.3390/mi12010037.

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Three-dimensional (3D) cell cultures and organs-on-a-chip have been developed to construct microenvironments that resemble the environment within the human body and to provide a platform that enables clear observation and accurate assessments of cell behavior. However, direct observation of transendothelial electrical resistance (TEER) has been challenging. To improve the efficiency in monitoring the cell development in organs-on-a-chip, in this study, we designed and integrated commercially available TEER measurement electrodes into an in vitro blood-brain barrier (BBB)-on-chip system to quan

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Cameron, Tiffany, Tanya Bennet, Elyn Rowe, Mehwish Anwer, Cheryl Wellington, and Karen Cheung. "Review of Design Considerations for Brain-on-a-Chip Models." Micromachines 12, no. 4 (2021): 441. http://dx.doi.org/10.3390/mi12040441.

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In recent years, the need for sophisticated human in vitro models for integrative biology has motivated the development of organ-on-a-chip platforms. Organ-on-a-chip devices are engineered to mimic the mechanical, biochemical and physiological properties of human organs; however, there are many important considerations when selecting or designing an appropriate device for investigating a specific scientific question. Building microfluidic Brain-on-a-Chip (BoC) models from the ground-up will allow for research questions to be answered more thoroughly in the brain research field, but the design

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Wang, Peng, Yunsong Wu, Wenwen Chen, Min Zhang, and Jianhua Qin. "Malignant Melanoma-Derived Exosomes Induce Endothelial Damage and Glial Activation on a Human BBB Chip Model." Biosensors 12, no. 2 (2022): 89. http://dx.doi.org/10.3390/bios12020089.

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Malignant melanoma is a type of highly aggressive tumor, which has a strong ability to metastasize to brain, and 60–70% of patients die from the spread of the tumor into the central nervous system. Exosomes are a type of nano-sized vesicle secreted by most living cells, and accumulated studies have reported that they play crucial roles in brain tumor metastasis, such as breast cancer and lung cancer. However, it is unclear whether exosomes also participate in the brain metastasis of malignant melanoma. Here, we established a human blood–brain barrier (BBB) model by co-culturing human brain mic

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Yang, Jung Yoon, Dae-Seop Shin, Moonkyu Jeong, et al. "Evaluation of Drug Blood-Brain-Barrier Permeability Using a Microfluidic Chip." Pharmaceutics 16, no. 5 (2024): 574. http://dx.doi.org/10.3390/pharmaceutics16050574.

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The blood-brain-barrier (BBB) is made up of blood vessels whose permeability enables the passage of some compounds. A predictive model of BBB permeability is important in the early stages of drug development. The predicted BBB permeabilities of drugs have been confirmed using a variety of in vitro methods to reduce the quantities of drug candidates needed in preclinical and clinical trials. Most prior studies have relied on animal or cell-culture models, which do not fully recapitulate the human BBB. The development of microfluidic models of human-derived BBB cells could address this issue. We

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Emeh, Promise, Kevin Jimenez-Cowell, Martine Lamfers, et al. "Abstract 1217: Modelling GBM-vasculature interaction on chip." Cancer Research 85, no. 8_Supplement_1 (2025): 1217. https://doi.org/10.1158/1538-7445.am2025-1217.

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Abstract The tumor microenvironment (TME) in glioblastoma (GBM) is remarkably intricate, characterized by its dynamic nature and high heterogeneity that significantly influence tumor progression and treatment resistance. The heterogeneous TME comprises of blood vessels, immune cells, neurons, and the blood-brain barrier (BBB) presenting distinct tumor compartments that influence the tumor behavior. A recent classification based on the heterogeneous TME identified three distinct subtypes TMELow, TMEMed, and TMEHigh distinguished by varying endothelial and immune cell populations. This study exp

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Koch, Eugen V., Verena Ledwig, Sebastian Bendas, Stephan Reichl, and Andreas Dietzel. "Tissue Barrier-on-Chip: A Technology for Reproducible Practice in Drug Testing." Pharmaceutics 14, no. 7 (2022): 1451. http://dx.doi.org/10.3390/pharmaceutics14071451.

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One key application of organ-on-chip systems is the examination of drug transport and absorption through native cell barriers such the blood–brain barrier. To overcome previous hurdles related to the transferability of existing static cell cultivation protocols and polydimethylsiloxane (PDMS) as the construction material, a chip platform with key innovations for practical use in drug-permeation testing is presented. First, the design allows for the transfer of barrier-forming tissue into the microfluidic system after cells have been seeded on porous polymer or Si3N4 membranes. From this, we ca

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Miccoli, Beatrice, Dries Braeken, and Yi-Chen Ethan Li. "Brain-on-a-chip Devices for Drug Screening and Disease Modeling Applications." Current Pharmaceutical Design 24, no. 45 (2019): 5419–36. http://dx.doi.org/10.2174/1381612825666190220161254.

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:Neurodegenerative disorders are related to the progressive functional loss of the brain, often connected to emotional and physical disability and, ultimately, to death. These disorders, strongly connected to the aging process, are becoming increasingly more relevant due to the increase of life expectancy. Current pharmaceutical treatments poorly tackle these diseases, mainly acting only on their symptomology. One of the main reasons of this is the current drug development process, which is not only expensive and time-consuming but, also, still strongly relies on animal models at the preclinic

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Cameron, Tiffany C., Avineet Randhawa, Samantha M. Grist, et al. "PDMS Organ-On-Chip Design and Fabrication: Strategies for Improving Fluidic Integration and Chip Robustness of Rapidly Prototyped Microfluidic In Vitro Models." Micromachines 13, no. 10 (2022): 1573. http://dx.doi.org/10.3390/mi13101573.

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The PDMS-based microfluidic organ-on-chip platform represents an exciting paradigm that has enjoyed a rapid rise in popularity and adoption. A particularly promising element of this platform is its amenability to rapid manufacturing strategies, which can enable quick adaptations through iterative prototyping. These strategies, however, come with challenges; fluid flow, for example, a core principle of organs-on-chip and the physiology they aim to model, necessitates robust, leak-free channels for potentially long (multi-week) culture durations. In this report, we describe microfluidic chip fab

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Ohbuchi, Masato, Mayu Shibuta, Kazuhiro Tetsuka, et al. "Modeling of Blood–Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research." International Journal of Molecular Sciences 25, no. 12 (2024): 6496. http://dx.doi.org/10.3390/ijms25126496.

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Blood–brain barrier (BBB) dysfunction is a key feature in neuroimmunological and neurodegenerative diseases. In this study, we developed a microfluidic human BBB-on-a-chip to model barrier dysfunction and immune cell migration using immortalized TY10 brain endothelial cells, pericytes, and astrocytes. It was found that immortalized TY10 brain endothelial cells developed a microvascular structure under flow. Pericytes were localized on the basal side surrounding the TY10 microvascular structure, showing an in vivo-like structure. Barrier integrity increased under co-culture with pericytes. In a

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Kawakita, Satoru, Kalpana Mandal, Lei Mou, et al. "Organ‐On‐A‐Chip Models of the Blood–Brain Barrier: Recent Advances and Future Prospects (Small 39/2022)." Small 18, no. 39 (2022): 2270210. http://dx.doi.org/10.1002/smll.202270210.

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YANG, Pan-Hui, Feng-Yi ZHENG, Qiu-Shi LI, et al. "An easy-repeat method to build a blood-brain barrier model on a chip with independent TEER detection module." Chinese Journal of Analytical Chemistry 50, no. 2 (2022): 97–101. http://dx.doi.org/10.1016/j.cjac.2021.11.003.

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Herland, Anna, Andries D. van der Meer, Edward A. FitzGerald, Tae-Eun Park, Jelle J. F. Sleeboom, and Donald E. Ingber. "Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip." PLOS ONE 11, no. 3 (2016): e0150360. http://dx.doi.org/10.1371/journal.pone.0150360.

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Andrews, Allison M., Evan M. Lutton, Lee A. Cannella, et al. "Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures." Journal of Cerebral Blood Flow & Metabolism 38, no. 5 (2017): 888–903. http://dx.doi.org/10.1177/0271678x17708690.

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Endothelial cells (ECs) form the basis of the blood–brain barrier (BBB), a physical barrier that selectively restricts transport into the brain. In vitro models can provide significant insight into BBB physiology, mechanisms of human disease pathology, toxicology, and drug delivery. Given the limited availability of primary human adult brain microvascular ECs ( aBMVECs), human fetal tissue offers a plausible alternative source for multiple donors and the opportunity to build syngenic tri-cultures from the same host. Previous efforts to culture fetal brain microvascular ECs ( fBMVECs) have not

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Chen, Xingchi, Chang Liu, Laureana Muok, Changchun Zeng, and Yan Li. "Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases." Cells 10, no. 11 (2021): 3183. http://dx.doi.org/10.3390/cells10113183.

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The blood–brain barrier (BBB) is a vital structure for maintaining homeostasis between the blood and the brain in the central nervous system (CNS). Biomolecule exchange, ion balance, nutrition delivery, and toxic molecule prevention rely on the normal function of the BBB. The dysfunction and the dysregulation of the BBB leads to the progression of neurological disorders and neurodegeneration. Therefore, in vitro BBB models can facilitate the investigation for proper therapies. As the demand increases, it is urgent to develop a more efficient and more physiologically relevant BBB model. In this

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