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Journal articles on the topic 'Blood coagulation tests'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

FUJIKATA, Akira, and Yayoi IKEDA. "Blood coagulation and clotting tests in carp." NIPPON SUISAN GAKKAISHI 51, no. 6 (1985): 933–39. http://dx.doi.org/10.2331/suisan.51.933.

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2

Yavas, Soner, Selime Ayaz, Serdal Kenan Kose, Fatma Ulus, and Tulga Ahmet Ulus. "Influence of Blood Collection Systems on Coagulation Tests." Turkish Journal of Hematology 29, no. 4 (2012): 367–75. http://dx.doi.org/10.5505/tjh.2012.59254.

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3

Kozmin, L. D., A. I. Martinov, T. A. Lisitsina, T. M. Reshetnyak, V. I. Lauga, and O. P. Bliznukov. "C-reactive protein prolongs blood coagulation time in phospholipids-dependent coagulation tests." Rheumatology Science and Practice, no. 3 (June 15, 2003): 16. http://dx.doi.org/10.14412/1995-4484-2003-1353.

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4

Wisser, Dirk, Klaus van Ackern, Ernst Knoll, Hermann Wisser, and Thomas Bertsch. "Blood Loss from Laboratory Tests." Clinical Chemistry 49, no. 10 (October 1, 2003): 1651–55. http://dx.doi.org/10.1373/49.10.1651.

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Abstract Background: Laboratory tests can be an important source of blood loss in hospitals, especially for newborns and patients in intensive care. The aim of this study was to quantify blood loss for laboratory diagnostic tests in a large number of patients in a teaching hospital. Methods: We estimated blood loss by multiplying the number and volumes of sampling tubes collected from 2654 adult inpatients. We compared the number of tests per patient for all inpatients and intensive care unit patients during the first period and again in the same time period 1 year later when cumulative blood-

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Krishnamurthy, Dr Vani, and Rubiya Ahmad. "Comparison of various principles of coagulation tests in handling hemolysed blood samples." Tropical Journal of Pathology and Microbiology 7, no. 4 (August 31, 2021): 188–93. http://dx.doi.org/10.17511/jopm.2021.i04.06.

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Background: Rejection of hemolysed samples for coagulation test is the standard practice.However, when clinicians deal with extremely sick patients where repeat sampling is difficult toobtain, rejection of the sample is a lost opportunity for the lab physician to assist inpatient care.Proceeding with the test and providing a clinically helpful interpretation of the results will ensure theactive participation of the laboratory physician. Different principles of coagulation testing handle thehemolysed samples differently. It is essential to know the best principle to proceed with thehemolysed sa

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KITAJIMA, Isao. "The clinical laboratory tests of blood coagulation and fibrinolysis." Japanese Journal of Thrombosis and Hemostasis 19, no. 4 (2008): 462–66. http://dx.doi.org/10.2491/jjsth.19.462.

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Ferrigno, D., G. Buccheri, and I. Ricca. "Prognostic significance of blood coagulation tests in lung cancer." European Respiratory Journal 17, no. 4 (April 1, 2001): 667–73. http://dx.doi.org/10.1183/09031936.01.17406670.

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Norén, Ingrid, and Astrid Gårde. "Value of Blood Coagulation Tests in Ischemic Cerebral Disease." European Neurology 25, no. 5 (1986): 330–38. http://dx.doi.org/10.1159/000116031.

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Edwards, Richard L., Frederick R. Rickles, Thomas E. Moritz, William G. Henderson, Leo R. Zacharski, Walter B. Forman, C. J. Cornell, et al. "Abnormalities of Blood Coagulation Tests in Patients with Cancer." American Journal of Clinical Pathology 88, no. 5 (November 1, 1987): 596–602. http://dx.doi.org/10.1093/ajcp/88.5.596.

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10

Larsen, Julie, and Anne-Mette Hvas. "Predictive Value of Whole Blood and Plasma Coagulation Tests for Intra- and Postoperative Bleeding Risk: A Systematic Review." Seminars in Thrombosis and Hemostasis 43, no. 07 (July 18, 2017): 772–805. http://dx.doi.org/10.1055/s-0037-1602665.

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AbstractExcessive perioperative bleeding is associated with increased morbidity and mortality as well as increased economic costs. A range of whole blood laboratory tests for hemostatic monitoring has emerged, but their ability to predict perioperative bleeding is still debated. We conducted a systematic review of the existing literature assessing the ability of whole blood coagulation (thromboelastography [TEG]/thromboelastometry [ROTEM]/Sonoclot), platelet function tests, and standard plasma-based coagulation tests to predict bleeding in the perioperative setting. We searched PubMed and Emba

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Mohammed Amood Al-Kamarany, Nabil Ahmed Albaser, Hussein Omar Kadi, and Badiaa Lyoussi. "Effect of Khat on Blood Coagulation." Abhath Journal of Basic and Applied Sciences 1, no. 2 (December 30, 2022): 1–5. http://dx.doi.org/10.59846/abhathjournalofbasicandappliedsciences.v1i2.437.

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Catha edulis Forsk leaves " Khat " are chewed daily by a high proportion of the adult population in Yemen .The present study investigated the relationship between blood coagulation and khat chewing .In our study , we investigated the blood coagulation tests in two groups namely khat chewers group (n:30) and non– khat chewers group (n:60). The blood coagulation tests included bleeding time , clotting time , prothrombin time , partial thromboplastin time and platelets count. Statistical testing for data analysis included the student's t-test and chi 2 test. The results presented show the level o

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Gabarin, Nadia, Martina Trinkaus, Rita Selby, Nicola Goldberg, Jessica Petrucci, Hina Chaudhry, and Michelle Sholzberg. "Can an Online Educational Module Improve Medical Trainee Confidence and Knowledge of Coagulation?" Blood 134, Supplement_1 (November 13, 2019): 4695. http://dx.doi.org/10.1182/blood-2019-129385.

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Background: Coagulation has notoriously been a topic that medical trainees find challenging to learn. A lack of understanding around coagulation has led to widespread inappropriate ordering of commonly used coagulation tests, including the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). Despite these tests being validated for specific clinical indications, they are frequently ordered as screening tests in unselected patients, and often ordered together, suggesting a gap in physician understanding of coagulation and appropriate testing. To explore this further, we co

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Ahmed, A. "Monitoring of blood clotting during bleeding." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 12–13. http://dx.doi.org/10.32902/2663-0338-2020-3.2-12-13.

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Background. The risk of bleeding and thrombotic events should be weighed before, during and after surgery. To facilitate this process, it is advisable to ask yourself the following questions: if we start the operation now, will the bleeding develop? If we delay the intervention, will a thrombotic event occur? Are the patient’s antithrombotic drugs effective? Objective. To describe the blood coagulation monitoring system. Materials and methods. Analysis of literature sources on this topic. Results and discussion. Coagulopathy can be congenital and acquired, the latter includin

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Romano, Francesca, Francesco Del Monte, Ugo Ramenghi, and Emilia Parodi. "Le prove coagulative nel bambino sano (seconda parte)." Medico e Bambino 42, no. 5 (May 27, 2023): 307–11. http://dx.doi.org/10.53126/meb42307.

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In Paediatrics, coagulation tests are often prescribed in children without bleeding symptoms, for example before surgery/invasive procedures, or in case of family history of coagulopathy. Moreover, sometimes impairment in coagulation tests is occasionally found in routine blood tests. This brief article presents a practical approach to guide the family paediatrician on the indications for coagulation tests and the interpretation of any abnormality found in otherwise “healthy” children.

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FUKUTAKE, Katsuyuki. "Necessity and current state of standardization in blood coagulation tests." Japanese Journal of Thrombosis and Hemostasis 27, no. 6 (2016): 617–22. http://dx.doi.org/10.2491/jjsth.27.617.

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16

Brown, J. M., and G. Dimeski. "Contamination of coagulation tests with heparin from blood gas samples." British Journal of Anaesthesia 87, no. 4 (October 2001): 628–29. http://dx.doi.org/10.1093/bja/87.4.628.

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17

Park, Sun Young. "Viscoelastic coagulation test for liver transplantation." Anesthesia and Pain Medicine 15, no. 2 (April 30, 2020): 143–51. http://dx.doi.org/10.17085/apm.2020.15.2.143.

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Coagulation and transfusion management in patients undergoing liver transplantation is challenging. Proper perioperative monitoring of hemostasis is essential to predict the risk of bleeding during surgery, to detect potential causes of hemorrhage in time, and to guide hemostatic therapy. The value of conventional coagulation test is questionable in the acute perioperative setting due to their long turnaround time and the inability to adequately reflect the complex changes in hemostasis in patients with liver disease. Viscoelastic coagulation tests provide simultaneous measurement of multiple

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Ataullakhanov, F. I., and A. G. Rumyantsev. "New insights into the blood clotting." Russian Journal of Children Hematology and Oncology 5, no. 3 (September 14, 2018): 13–22. http://dx.doi.org/10.17650/2311-1267-2018-5-3-13-22.

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In recent years, an active revision of ideas about the mechanisms of blood clotting has been performed. Traditional views were largely inaccurate, which is the main reason for the inconsistency of the modern standard set of coagulation tests. This set was found to be insensitive, especially to hypercoagulable disorders. In this paper, we consider modern concepts of how blood clotting occurs. From this consideration follows the need for a critical review of existing methods for assessing the status of hemostasis and a standard set of laboratory tests. The lecture ends with a brief examination o

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Vetrile, S. T., R. G. Zakharin', A. I. Bernakevich', S. A. Vasil'ev, A. A. Kuleshov, S. T. Vetrile, R. G. Zakharin, A. I. Bernakevich, S. A. Vasil'ev, and A. A. Kuleshov. "Coagulation Hemostasis in Surgical Treatment of Scoliosis." N.N. Priorov Journal of Traumatology and Orthopedics 10, no. 4 (December 15, 2003): 64–68. http://dx.doi.org/10.17816/vto200310464-68.

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In 95 patients, operated on for scoliosis, coagulation status was studied using standard tests (activated partial thromboplastin time, prothrombin decrease by Quick, normolized prothrombin ratio, antithrombin III, ethanol and orthophenothroline tests, ХП-a dependent fibrinolysis) pre-, intra- and postoperatively. It was shown that coagulation disturbances developed already during the hemodilution process. Consumption of coagulation factors took place during operation and at early postoperative period. Blood loss by drainage was marked during 48 hours after operation. Maximum changes of coagula

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20

Simioni, Paolo. "Classical and Point-of-Care tests in severe hemorrhage management." AboutOpen 9 (July 31, 2022): 47–51. http://dx.doi.org/10.33393/ao.2022.2433.

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Hemorrhage is defined as an acute loss of blood from the cardiovascular system. The hemostatic cascade (comprising the vasculature, coagulation factors, the fibrinolytic and the platelet systems) is the physiological mechanism meant to control this event. Coagulation assessment is fundamental in the monitoring and treatment of hemorrhage. Over the years several classical laboratory-based diagnostic tests have been developed for the management of severe hemorrhage, however their main downside is the time necessary to obtain a result, which can be significant (between 40 minutes and an hour) and

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21

Banković Radovanović, Patricija, Tanja Živković Mikulčić, and Jasmina Simović Medica. "Unexpected abnormal coagulation test results in a 2-year-old child." Biochemia medica 30, no. 1 (February 15, 2020): 158–63. http://dx.doi.org/10.11613/bm.2020.011002.

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Rejection of the sample with repeated blood withdrawal is always an unwanted consequence of sample nonconformity and preanalytical errors, especially in the most vulnerable population – children. Here is presented a case with unexpected abnormal coagulation test results in a 2-yearold child with no previously documented coagulation disorder. Child is planned for tympanostomy tubes removal under the anaesthesia driven procedure, and preoperative coagulation tests revealed prolonged prothrombin time, activated partial thromboplastin time and thrombin time, with fibrinogen and antithrombin within

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22

Batarseh, Mahed, Jose Rafael Guzman-Sepulveda, Ruitao Wu, William M. DeCampli, and Aristide Dogariu. "Passive Coagulability Assay Based on Coherence-Gated Light Scattering." Hemato 1, no. 2 (October 20, 2020): 49–59. http://dx.doi.org/10.3390/hemato1020009.

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Coagulation monitoring relies on in vitro tests where the clot formation is induced using external stimuli. We report an optical method capable of revealing the propensity of coagulation based solely on the natural dynamics of erythrocytes in whole blood. In contrast to traditional techniques, our approach provides means to assess the blood coagulability without the need to chemically trigger the coagulation. Results of correlations with standard clinical methods suggest that this optical assay could be used for continuous management of blood coagulation during clinical procedures.

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23

IRIE, Yohji, Hiroko YOSHIDA, Katsuyuki KAI, Yasushi MAKINO, Shinji SHIBATA, and Katsuya KITOH. "Reference Intervals Using the Dry-system Coagulation Analyzer COAG2V for Blood Coagulation Tests in Dogs." Journal of the Japan Veterinary Medical Association 72, no. 7 (July 20, 2019): 417–22. http://dx.doi.org/10.12935/jvma.72.417.

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24

Putnis, Soni, Joe Nanuck, and Dugal Heath. "An Audit of Preoperative Blood Tests." Journal of Perioperative Practice 18, no. 2 (February 2008): 56–59. http://dx.doi.org/10.1177/175045890801800201.

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Purpose Audit of the use of preoperative blood tests in elective general surgery in a district general hospital. Comparison is made with the National Institute for Health and Clinical Excellence (NICE) guidelines and recommendations. Methodology Retrospective audit of preoperative blood tests performed for elective general surgical patients in a district general hospital over a one month period. Findings Patients attending preoperative assessment for general surgery have blood tests performed in excess of the NICE guidelines. The most frequently requested test that is performed against NICE gu

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25

Tanaka, Kenichi, and Daniel Bolliger. "Point-of-Care Coagulation Testing in Cardiac Surgery." Seminars in Thrombosis and Hemostasis 43, no. 04 (March 30, 2017): 386–96. http://dx.doi.org/10.1055/s-0037-1599153.

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AbstractBleeding complications after cardiac surgery are common and are associated with increased morbidity and mortality. Their etiology is multifactorial, and treatment decisions are time sensitive. Point-of-care (POC) testing has an advantage over standard laboratory tests for faster turn-around times, and timely decision on coagulation intervention(s). The most common POC coagulation testing is the activated clotting time (ACT), used to monitor heparin therapy while on cardiopulmonary bypass. Viscoelastic coagulation tests including thromboelastometry (ROTEM) and thromboelastography (TEG)

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Subbarayan, Devi, Chidambharam Choccalingam, and Chittode Kodumudi Anantha Lakshmi. "The Effects of Sample Transport by Pneumatic Tube System on Routine Hematology and Coagulation Tests." Advances in Hematology 2018 (July 2, 2018): 1–4. http://dx.doi.org/10.1155/2018/6940152.

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Background. Automation helps improve laboratory operational efficiency and reduce the turnaround time. Pneumatic tube systems (PTS) automate specimen transport between the lab and other areas of the hospital. Its effect on complete blood count (CBC) and coagulation is still controversial.Aim. To study the effects of pneumatic tube system sample transport on complete blood count and coagulation parameters to compare them with hand delivered samples.Methods. 75 paired samples for complete blood count and 25 paired samples for coagulation analysis were compared between samples sent via pneumatic

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27

Brahimi, Mohamed, Farah Bouamama, Assia Alem, Amel Mihoubi, and Mohamed Amine Bekadja. "Les examens de laboratoire en hématologie." Batna Journal of Medical Sciences (BJMS) 2, no. 2 (December 30, 2012): 172–76. http://dx.doi.org/10.48087/bjmstf.2015.2216.

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Complete blood cell count (CBC) and coagulation screening tests are the most performed laboratory tests. These two assays must be done systematically in various occasions since many blood disorders can be pauci or asymptomatic, and every illness may lead to their disturbance. For these reasons these tests are described in this paper. Nowadays, the majority of CBCs are performed using eighteen parameters automatic counters. For pedagogic reasons, this load of parameters is divided into three parts: red blood cells (RBCs), white blood cells (WBCs) and platelets parameters and the alteration of e

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Despotis, George J., J. Heinrich Joist, and Lawrence T. Goodnough. "Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes." Clinical Chemistry 43, no. 9 (September 1, 1997): 1684–96. http://dx.doi.org/10.1093/clinchem/43.9.1684.

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Abstract Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at increased risk for excessive perioperative blood loss requiring transfusion of blood products. Strategies to optimize administration of heparin and protamine and the assessment of their effects on coagulation are evolving in cardiac surgical patients. Two recent evaluations have focused on the use of multiple point-of-care (POC) coagulation assays for patient-specific adjustment of heparin and protamine dosage. These studies indicate that blood loss and transfusion requirements in cardiac surgical patients ma

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Vlot, Eline A., Eric P. A. van Dongen, Laura M. Willemsen, Jur M. ten Berg, Christian M. Hackeng, Stephan A. Loer, and Peter G. Noordzij. "Association of Plasma Fibrinogen and Thromboelastography With Blood Loss in Complex Cardiac Surgery." Clinical and Applied Thrombosis/Hemostasis 27 (January 1, 2021): 107602962110165. http://dx.doi.org/10.1177/10760296211016541.

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Postoperative coagulopathic bleeding is common in cardiac surgery and is associated with increased morbidity and mortality. Ideally, real-time information on in-vivo coagulation should be available. However, up to now it is unclear which perioperative coagulation parameters can be used best to accurately identify patients at increased risk of bleeding. The present study analyzed the associations of perioperative fibrinogen concentrations and whole blood viscoelastic tests with postoperative bleeding in 89 patients undergoing combined cardiac surgery procedures. Postoperative bleeding was recor

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Oberhardt, Bruce J., Patrick D. Mize, and Cynthia G. Pritchard. "Point-of-care fibrinolytic tests: the other side of blood coagulation." Clinical Chemistry 43, no. 9 (September 1, 1997): 1697–702. http://dx.doi.org/10.1093/clinchem/43.9.1697.

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Abstract Point-of-care (POC) coagulation tests with paramagnetic iron oxide particles have provided alternatives to testing previously done only in the laboratory. With this technology, POC fibrinolytic tests have followed quietly the trail blazed by POC clotting tests and have found specific applications. These include rapid verification of in vivo thrombolytic drug action by in vitro testing with subsequent quantitative drug monitoring of the systemic lytic state, and also the determination of in vitro thrombolytic drug response before the drug is actually administered, to individualize ther

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Yue, Liang, Yasuhiro Nakagawa, and Mitsuhiro Ebara. "Design of Apoptotic Cell-Inspired Particles as a Blood Coagulation Test." Biomimetics 9, no. 6 (June 17, 2024): 367. http://dx.doi.org/10.3390/biomimetics9060367.

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The blood coagulation test is an indispensable test for monitoring the blood coagulation and fibrinolysis functions. Currently, activated partial thromboplastin time (APTT) is the most widely used approach to coagulation testing. However, APTT reagents need to be optimized due to the fact that they are unstable, highly variable, and cannot be easily controlled. In this study, we created apoptotic cell-inspired methacryloyloxyethyl phosphorylserine (MPS) particles for blood coagulation as an alternative to conventional APTT reagents. Particle size could be controlled by changing the concentrati

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Weatherby, H., V. Woolner, L. Chartier, S. Casey, C. Ong, and E. Gaylord. "LO37: Reducing hemolysis of coagulation blood samples in the emergency department." CJEM 22, S1 (May 2020): S20. http://dx.doi.org/10.1017/cem.2020.92.

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Background: Hemolysis of blood samples is the leading cause of specimen rejection from hospital laboratories. It contributes to delays in patient care and disposition decisions. Coagulation tests (prothrombin time/international normalized ratio [PT/INR] and activated partial thromboplastin time [aPTT]) are especially problematic for hemolysis in our academic hospital, with at least one sample rejected daily from the emergency department (ED). Aim Statement: We aimed to decrease the monthly rate of hemolyzed coagulation blood samples sent from the ED from a rate of 2.9% (53/1,857) to the best p

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Alberts, Karl Akke, Ingrid Norén, Margareta Rubin, and Staffan Törngren. "Respiratory distress following major trauma: Predictive value of blood coagulation tests." Acta Orthopaedica Scandinavica 57, no. 2 (January 1986): 158–62. http://dx.doi.org/10.3109/17453678609000892.

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SAMAMA, M. "LOW DOSE HEPARIN IN GYNAECOLOGICAL SURGERY: EFFECT ON BLOOD COAGULATION TESTS." Scandinavian Journal of Haematology 24, S36 (April 24, 2009): 101–11. http://dx.doi.org/10.1111/j.1600-0609.1980.tb02518.x.

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Görög, P., and I. B. Kovacs. "Coagulation of flowing native blood: Advantages over stagnant (tube) clotting tests." Thrombosis Research 64, no. 5 (December 1991): 611–19. http://dx.doi.org/10.1016/s0049-3848(05)80010-6.

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Görög, P., and I. B. Kovacs. "Coagulation of flowing native blood: Advantages over stagnant (tube) clotting tests." Thrombosis Research 65, no. 5 (December 1991): 611–19. http://dx.doi.org/10.1016/0049-3848(91)90335-t.

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Wu, John K., Janet C. McGeer, and James E. Carter. "Central venous line blood sampling for coagulation tests in hemodialysis patients." Pediatric Nephrology 10, no. 1 (February 1996): 128. http://dx.doi.org/10.1007/bf00863466.

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Kumura, Takeo, Masayuki Hino, Takahisa Yamane, and Noriyuki Tatsumi. "Hirudin as an anticoagulant for both haematology and chemistry tests." Journal of Automated Methods and Management in Chemistry 22, no. 4 (2000): 109–12. http://dx.doi.org/10.1155/s1463924600000158.

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Hirudin, an extract from the leech, has powerful antithrombin activity affecting the blood coagulation pathway. We evaluated the usefulness of hirudin in anticoagulating specimens for routine laboratory tests. Results using blood anticoagulated with hirudin corresponded well with results with blood treated with ethylenediamine tetraacetic acid (EDTA) in the complete blood count (CBC), including white blood cell (WBC) differential count and morphology of blood cells, when CBC was performed within 2 h of blood collection. Clinical chemistry results from hirudin-treated samples were similar to re

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Helmond, Noud van, Blair D. Johnson, Timothy B. Curry, Andrew P. Cap, Victor A. Convertino, and Michael J. Joyner. "Coagulation changes during lower body negative pressure and blood loss in humans." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 9 (November 2015): H1591—H1597. http://dx.doi.org/10.1152/ajpheart.00435.2015.

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We tested the hypothesis that markers of coagulation activation are greater during lower body negative pressure (LBNP) than those obtained during blood loss (BL). We assessed coagulation using both standard clinical tests and thrombelastography (TEG) in 12 men who performed a LBNP and BL protocol in a randomized order. LBNP consisted of 5-min stages at 0, −15, −30, and −45 mmHg of suction. BL included 5 min at baseline and following three stages of 333 ml of blood removal (up to 1,000 ml total). Arterial blood draws were performed at baseline and after the last stage of each protocol. We found

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Uhrikova, I., P. Scheer, J. Hlozkova, P. Suchy Jr, and M. Sepsi. "Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing." Veterinární Medicína 61, No. 9 (September 13, 2016): 528–32. http://dx.doi.org/10.17221/22/2016-vetmed.

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The aim of this study was to evaluate changes in coagulation tests, haptoglobin concentrations and leukocyte counts in rabbits with right-ventricle pacing medicated with acetylsalicylic acid (ASA). Blood was collected from 35 non-anaesthetised males from the jugular vein at baseline, one and two months after pacemaker implantation. Animals were divided into two groups: non-medicated and medicated with ASA. Total leukocyte and platelet counts were measured on an automatic veterinary flow cytometry haematological analyser. Prothrombin time, activated partial thromboplastin time, fibrinogen level

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Bercovitz, Rachel Sara. "An introduction to point-of-care testing in extracorporeal circulation and LVADs." Hematology 2018, no. 1 (November 30, 2018): 516–21. http://dx.doi.org/10.1182/asheducation-2018.1.516.

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Abstract There is a delicate balance between bleeding and clotting in patients on circuits such as ventricular assist devices or extracorporeal membrane oxygenation. Traditional coagulation tests, prothrombin time, activated partial thromboplastin time, and anti-factor Xa levels, are used to monitor patients on these devices. However, turnaround times and inability to assess global hemostasis, including platelets and fibrinogen have contributed to a recognition that faster, accurate, and more informative coagulation tests are needed. Activated clotting time is used to monitor heparin in patien

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Aronniemi, Johanna, Satu Långström, Katariina A. Mattila, Anne Mäkipernaa, Päivi Salminen, Anne Pitkäranta, Johanna Pekkola, and Riitta Lassila. "Venous Malformations and Blood Coagulation in Children." Children 8, no. 4 (April 20, 2021): 312. http://dx.doi.org/10.3390/children8040312.

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Introduction: Venous malformations (VMs) are congenital low-flow lesions with a wide spectrum of clinical manifestations. An increasing number of studies link VMs to coagulation abnormalities, especially to elevated D-dimer and decreased fibrinogen. This condition, termed localized intravascular coagulopathy (LIC), may pose a risk for hemostatic complications. However, detailed data on the laboratory variables for coagulation and fibrinolytic activity in VM patients are limited. We addressed this question by systematically analyzing the coagulation parameters in pediatric VM patients. Methods:

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Fries, D. "Coagulation management in massive transfusion." Hämostaseologie 26, S 02 (2006): S15—S20. http://dx.doi.org/10.1055/s-0037-1617077.

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SummaryWhen no fresh frozen plasma is available, acute major blood loss is compensated above all with crystalloids, colloids and red blood cell concentrates, meaning that all plasma clotting factors are diluted. So far, consumption coagulopathy is almost always accompanied by dilutional coagulopathy. Formulas for calculating critical blood loss and standard coagulation tests are often not helpful in the case of massive transfusion. On the other hand, systems suitable for point of care, such as thrombelastography, have important advantages. In the case of consumption and dilutional coagulopathy

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Kim, Jinju, Yejin Song, Hyun-Jeong Kim, Mi-Sook Yang, and Jaewoo Song. "Relative Interfering Effects of In Vivo Direct Oral Anticoagulants on Routine Coagulation Tests." Blood 138, Supplement 1 (November 5, 2021): 4238. http://dx.doi.org/10.1182/blood-2021-152088.

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Abstract Background: The interfering effects of DOACs on the screening coagulation tests, such as prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen assay, have been shown mainly by in vitro spiking experiments. However, the effects of DOACs on coagulation tests in real-world samples from anticoagulated patients are unknown because of the difficulty in selectively eliminating DOAC from blood samples already containing DOACs. Method: Citrated blood samples were drawn from patients on anticoagulation therapy (rivaroxaban and edoxaban). In addition, blood samples

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Marsden, Nicholas J., Martin Van, Samera Dean, Ernest A. Azzopardi, Sarah Hemington-Gorse, Phillip A. Evans, and Iain S. Whitaker. "Measuring coagulation in burns: an evidence-based systematic review." Scars, Burns & Healing 3 (January 1, 2017): 205951311772820. http://dx.doi.org/10.1177/2059513117728201.

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Introduction: Dynamic monitoring of coagulation is important to predict both haemorrhagic and thrombotic complications and to guide blood product administration. Reducing blood loss and tailoring blood product administration may improve patient outcome and reduce mortality associated with transfusion. The current literature lacks a systematic, critical appraisal of current best evidence on which clinical decisions may be based. Objectives: Establishing the role of different coagulation markers in burn patients, diagnosing coagulopathy, tailoring blood product administration and indicating prog

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Zhou, Min, Xiaobo Luo, Qing Zhang, Xiaolan Yang, Xiaojing Li, and Renchi Yang. "Age-Associated Changes of Coagulation Test and Coagulation Factor Activities in Healthy Chinese Children." Blood 134, Supplement_1 (November 13, 2019): 4924. http://dx.doi.org/10.1182/blood-2019-123175.

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Background: The concept of developmental hemostasis has been universally accepted. Plasma concentrations of many coagulation factors in childhood are significantly different from adults for both mean values and ranges of normal. Thus, an understanding of developmental hemostasis and the development of appropriate age-dependent reference ranges are pivotal for prevention, diagnosis, and treatment of hemostatic problems during childhood. However, no data of developmental hemostasis are available in healthy Chinese children. Methods: Coagulation data from children aged 0-18 years old receiving mi

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Sweeney, D., and V. Williams. "The Effect of Halothane General Anaesthesia on Platelet Function." Anaesthesia and Intensive Care 15, no. 3 (August 1987): 278–81. http://dx.doi.org/10.1177/0310057x8701500306.

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Major craniofacial surgery has the potential for very large blood loss, frequently greater than one blood volume. In order that an assessment could be made of any deficiencies of platelet function or coagulation, tests were performed at intervals during the operation. None of the coagulation parameters showed variation below normal limits during the operation, but in vitro platelet aggregation showed significant decreases to several agonists.

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Wiegand, Cornelia, Martin Abel, Uta-Christina Hipler, Peter Elsner, Michael Zieger, Julia Kurz, Hans P. Wendel, and Sandra Stoppelkamp. "Hemostatic wound dressings: Predicting their effects by in vitro tests." Journal of Biomaterials Applications 33, no. 9 (February 21, 2019): 1285–97. http://dx.doi.org/10.1177/0885328219831095.

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Background Application of controlled in vitro techniques can be used as a screening tool for the development of new hemostatic agents allowing quantitative assessment of overall hemostatic potential. Materials and methods Several tests were selected to evaluate the efficacy of cotton gauze, collagen, and oxidized regenerated cellulose for enhancing blood clotting, coagulation, and platelet activation. Results Visual inspection of dressings after blood contact proved the formation of blood clots. Scanning electron microscopy demonstrated the adsorption of blood cells and plasma proteins. Signif

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Wedasingha, Supun, Geoffrey Isbister, and Anjana Silva. "Bedside Coagulation Tests in Diagnosing Venom-Induced Consumption Coagulopathy in Snakebite." Toxins 12, no. 9 (September 10, 2020): 583. http://dx.doi.org/10.3390/toxins12090583.

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Venom-induced consumption coagulopathy is the most important systemic effect of snake envenoming. Coagulation tests are helpful to accurately and promptly diagnose venom-induced consumption coagulopathy and administer antivenom, which is the only specific treatment available. However, bedside clotting tests play a major role in diagnosing coagulopathy in low-income settings, where the majority of snakebites occur. We conducted a literature search in MEDLINE® from 1946 to 30 November 2019, looking for research articles describing clinical studies on bedside coagulation tests in snakebite patien

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Tomić Mahečić, Tina, Robert Baronica, Anna Mrzljak, Ana Boban, Ivona Hanžek, Dora Karmelić, Anđela Babić, Slobodan Mihaljević, and Jens Meier. "Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease." Diagnostics 12, no. 12 (December 15, 2022): 3172. http://dx.doi.org/10.3390/diagnostics12123172.

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Over the last decades, individualized approaches and a better understanding of coagulopathy complexity in end-stage liver disease (ESLD) patients has evolved. The risk of both thrombosis and bleeding during minimally invasive interventions or surgery is associated with a worse outcome in this patient population. Despite deranged quantitative and qualitative coagulation laboratory parameters, prophylactic coagulation management is unnecessary for patients who do not bleed. Transfusion of red blood cells (RBCs) and blood products carries independent risks for morbidity and mortality, including m

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