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Journal articles on the topic 'Blood glucose parameters'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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Saeed, Quratulain, Sarwat Memon, Mervyn Hosein, and Sana Ikram. "Clinical Correlation of Periodontal Disease Parameters with Crevicular Blood Glucose Levels." Journal of the Pakistan Dental Association 30, no. 1 (2021): 12–17. http://dx.doi.org/10.25301/jpda.301.12.

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OBJECTIVE: The purpose of the study was to assess relationship between the clinical periodontal parameters and gingival crevicular blood glucose levels and to determine the relation of severity of periodontitis with glycemic levels. METHODOLOGY: A total number of 348 patients with chronic periodontitis participated in this cross-sectional study. After recording the number of teeth and plaque percentage, the participants were assessed for severity of periodontitis according to clinical periodontal parameters of periodontal pocket depth, gingival recession, clinical attachment loss and gingival bleeding. Gingival crevicular blood glucose was assessed via glucometers and random blood glucose levels were recorded for each patient. SPSS version 20 was used for data analysis. The correlation between periodontal parameters and glycemic levels was assessed via Pearson's correlation coefficient. Multiple regression analysis was used to predict the association of glycemic levels with periodontal parameters. Analysis of variance was used to compare the glycemic levels in patients with mild, moderate and advance periodontitis. RESULTS: Age, bleeding on probing and clinical attachment loss showed significant positive correlation while number of teeth showed significant negative association with crevicular blood glucose levels. Multiple regression analysis indicated that crevicular blood glucose has significant linear association with bleeding on probing and clinical attachment loss. Gingival crevicular blood glucose levels were found to be increasing with severity of periodontitis. There was significant difference (p<0.001) in mean glucose levels between mild, moderate and advanced periodontitis groups. CONCLUSION: Clinical periodontal parameters and severity of periodontitis are strongly associated with increasing gingival crevicular blood glucose levels. KEYWORDS: Blood glucose, inflammation, gingival bleeding, periodontitis HOW TO CITE: Saeed Q, Memon S, Hosein M, Ikram S. Clinical correlation of periodontal disease parameters with crevicular blood glucose levels. J Pak Dent Assoc 2021;30(1):12-17.

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Koschinsky, Theodor, Sascha Heckermann, and Lutz Heinemann. "Parameters Affecting Postprandial Blood Glucose: Effects of Blood Glucose Measurement Errors." Journal of Diabetes Science and Technology 2, no. 1 (2008): 58–66. http://dx.doi.org/10.1177/193229680800200109.

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Chhatriwala, Mitul N., Kiran Kumar B. Sodavadiya, Dharmik S. Patel, and Taskin H. Saiyad. "Establishment of Reference Interval of Blood Glucose and HbA1c in Tertiary Care Hospital of Anand District." International Journal of Pharmaceutical and Clinical Research 14, no. 4 (2022): 11–17. https://doi.org/10.5281/zenodo.13834229.

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Background: Health of an individual is conceptually different in different countries, in the same country at different times and in same individuals at different ages. The reference range varies considerably from one laboratory to another and is decedent on the population diet. Methodology, selection of reference group needs of the clinical. The clinical laboratory standard institute (CLSI, formerly known as NCCLS) recommended nonparametric (IFCC) recommends both nonparametric method and parametric method for the determination of reference ranges. Material and Methods: Present study was carried out in Central diagnostic laboratory of tertiary care hospital of Anand district over the period of one year. This cross-sectional study includes total 500 blood reports of RBS, FBS, PP2BS and HbA1c of all the individual who attended the routine health Checkup, outpatient department attending the hospital. All the data were expressed a Mean±2SD. Data analysis was done by using Statistical Software (SPSS-17). Kolmogorov-Smirnov (Z-test) was applied for all the parameters. Results and Discussion: Mean and SD values of random blood glucose, fasting blood glucose, postprandial blood glucose and HbA1c for male are 112.80±23.65 mg/dL, 99.02±9.99 mg/dL, 106.09±18.82 mg/dL, 5.59±0.38% respectively, and for female are 109.74±36.06 mg/dL, 100.51±10 mg/dL, 104.77±13 mg/dL, 5.65±0.38% respectively. Conclusion: Hence, from this study we conclude that the reference range obtained for biochemical parameters of glucose observed in defined population in a city is different from the values provided by the diagnostic kits. But we found the reference range of HbA1c is similar to available reference range.

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YATİNDRA, Ida Bagus Gde Tirta Yoga, Anak Agung Sagung Mirah PRABANDARİ, Pande Made Wisnu TİRTAYASA, Ida Bagus Tatwa YATİNDRA, Anak Agung Ngurah Oka DİATMİKA, and Kadek Cindy MERNİKA. "Correlation of blood glucose and prostatic-related parameters in patients with prostate enlargement." Journal of Experimental and Clinical Medicine 40, no. 1 (2023): 90–93. http://dx.doi.org/10.52142/omujecm.40.1.19.

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Enlarged prostate, either in benign prostatic hyperplasia or prostate cancer is the predominant urological disease affecting older men. Metabolic syndrome including high blood glucose was considered to take part in the development of prostate enlargement, although their association is still unclear. This study aims to investigate the correlation between blood glucose with prostatic-related parameters. A cross-sectional study was conducted involving 91 men with prostate enlargement from Urology Polyclinic, Tabanan Hospital, Bali Province, Indonesia. Prostatic-related parameters collected include patient’s international prostate symptoms score using the questionnaire, prostate-specific antigen and random blood glucose analysis from serum blood sample, and prostate volume determined with transabdominal ultrasonography. Patient’s mean age was 65.4 ± 10 years, mean prostate volume 52.7 ± 26 ml, mean prostate-specific antigen (PSA) 9.2 ± 17 ng/ml, mean international prostatic symptoms score (IPSS) 14.31 ± 7.1, mean random blood glucose 121.1 ± 40.5 mg/dl. This study found weak positive correlation between random blood glucose and prostate volume (r=0.269; p=0.01). PSA and prostate volume showed moderate positive correlation (r=0.365; p<0.001). No correlation between random blood glucose with PSA or IPSS was found in this study. This study found random blood glucose has positive correlation with prostate volume. We recommend enhancing blood glucose control to prevent the progress of prostate enlargement.

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Basri, Nur Rasyidah Hasan, Mas Sahidayana Mohktar, Wan Safwani Wan Kamarul Zaman, and Selvam Rengasamy. "Predicting Blood Glucose Level in Malaysian Women Based on Glutathione and Anthropometric Parameters." Acta Scientiarum. Technology 43 (September 23, 2021): e56373. http://dx.doi.org/10.4025/actascitechnol.v43i1.56373.

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Blood glucose is conventionally determined by the level of sugar present in our blood. Lesser known to the public that antioxidants in our body are also said to influence the level of blood glucose. Glutathione (GSH) as the main antioxidant parameter in our body helps in reducing the production of oxidative stress caused by a high blood glucose level. Particularly in women, high antioxidant activities are reported due to the presence of oestrogen hormone. However, in Malaysia limited study was done on the significance of GSH in influencing the blood glucose level. Thus, this study focuses on finding the significance of GSH and some other health predictors in affecting the blood glucose level of women volunteers. This study was carried out on 118 Malaysian women volunteers and blood samples were collected for GSH analysis and blood glucose. All data were trained and tested for the development of prediction models in classifying the blood glucose into normal and abnormal levels. The model construction is using three different classifiers: namely logistic regression, k-nearest neighbour classifier and decision tree. Five predictors that were used are GSH, weight, body mass index (BMI), waist-hip ratio (WHR) and groups (oral supplementation dosage). Results showed all predictors are significantly correlated with the blood glucose level at p < 0.10. The model with a combination of GSH, BMI, WHR, weight and supplementation dosage (groups) as predictors gave the best performance. The k-nearest neighbour classifier model displays the best accuracy (84.7%) in predicting the normal and abnormal level of blood glucose. This finding shows that by altering the amount of GSH via oral supplementation and other significant predictors in women, there are chances to modify the blood glucose level from abnormal to normal

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Karninčić, Hrvoje, Saša Krstulović, and Mario Baić. "The Influence of Body Weight on Chosen Physiological Parameters in Wrestling." Journal of Human Kinetics 37, no. 1 (2013): 119–27. http://dx.doi.org/10.2478/hukin-2013-0032.

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In this study, the authors attempted to determine whether the dynamics of blood lactate and glucose in wrestling depend on the weight class. Blood lactate and glucose curves during and after a wrestling match were determined. We also explained the dynamics of blood lactate and glucose in the context of recent glucose and lactate metabolism research. A sample of 60 youth wrestlers (15-20 years) were divided into three weight groups. Each athlete participated in one wrestling match. During the fight, the athletes' heart rate, glucose, and blood lactate were measured. The differences in body mass between the athletes did not affect the dynamics of lactate and glucose in wrestling competition (Fisher LSD test). We established that lactate and glucose dynamics are the same for all weight groups (Fisher LSD-Lactate 1 < 2 < 3 = 4 > 5, Fisher LSD-Glucose 1 = 2 < 3 < 4 < 5). Understanding lactate and glucose metabolism in wrestling is important for wrestling coaches because they need to evaluate a wrestler's anaerobic energy status.

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Godsland, I. F., C. Felton, and V. Wynn. "Venous Blood Arterialization and Parameters from the Minimal Models of Glucose Disappearance and Post-Hepatic Insulin Delivery." Clinical Science 85, no. 1 (1993): 89–95. http://dx.doi.org/10.1042/cs0850089.

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1. Modelling analysis of intravenous glucose tolerance test glucose and insulin concentrations can provide measures of insulin sensitivity and metabolism from a single straightforward procedure. However, little is known of the effects of blood arterialization on model-derived parameters. 2. Intravenous glucose tolerance tests were carried out on 18 subjects, with measurement of glucose and insulin concentrations in simultaneously sampled non-arterialized and arterialized blood. Blood oxygen saturation, partial pressure of CO2 and pH were measured on both non-arterialized and arterialized blood during the intravenous glucose tolerance test. Using the minimal models of glucose disappearance and post-hepatic insulin delivery, measures of insulin sensitivity, glucose-dependent glucose disposal, firstand second-phase post-hepatic insulin responsiveness to glucose and plasma insulin elimination rate were derived from intravenous glucose tolerance test glucose and insulin concentrations in both arterialized and non-arterialized blood. 3. During the intravenous glucose tolerance test mean blood oxygen saturation was 6.7% higher, partial pressure of CO2 was 0.3 kPa lower and pH was 0.015 higher in arterialized than non-arterialized blood. Mean parameter values did not differ when derived from measurements made on non-arterialized and arterialized blood. Model-derived parameters were not related to the degree of arterialization, although there was some consistent variation with sampling site for parameters of glucose-dependent glucose disposal (Sg), first-phase post-hepatic insulin responsiveness (φ1) and insulin elimination (ni). 4. Measurements made on non-arterialized blood are suitable for analyses employing the minimal models of glucose disappearance and post-hepatic insulin delivery. Imprecision in some parameters may be diminished by adherence to a single sampling site.

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Al-Taee, Nada Saad Naji. "Physiological blood parameters of young university adults with blood glucose, blood pressure and smokers." Indian Journal of Public Health Research & Development 9, no. 11 (2018): 481. http://dx.doi.org/10.5958/0976-5506.2018.01502.4.

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Mori, Fumihiko, Satoshi Ishiko, Tohru Abiko, et al. "Changes in corneal and lens autofluorescence and blood glucose levels in diabetics: parameters of blood glucose control." Current Eye Research 16, no. 6 (1997): 534–38. http://dx.doi.org/10.1076/ceyr.16.6.534.5079.

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Isehunwa, G. O., A. M. Adenuga, and A. R. A. Alada. "Comparative study of fasting blood glucose and haematological parameters of Wistar rat, Rattus norvegicus and the common African toad, Bufo regularis." Zoologist (The) 19, no. 1 (2022): 9–13. http://dx.doi.org/10.4314/tzool.v19i1.2.

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Haematological parameters are good indicators of the physiological status of animals and useful in understanding the relationship of blood to the environment. This study was carried out to compare the fasting levels of blood glucose and haematological parameters (Red blood cell count, Packed cell volume, Haemoglobin concentration, White blood cell count, Platelet count, and differential White blood cell counts) in Wistar rats, Rattus norvegicus and the common African toad, Bufo regularis. Ten rats and ten toads were used in the study. The animals were divided into two groups. Group I consists of 10 rats while Group II consists of 10 toads. The animals were fasted overnight before blood samples were collected for the determination of blood glucose and blood parameters. The blood glucose was determined using modified glucose oxidase method while the blood parameters were determined using standard laboratory techniques. The results of the study showed that the fasting blood glucose level in rats was significantly higher than that of toad. The fasting levels of blood parameters, packed cell volume, red blood cell counts, haemoglobin concentration in the toad were significantly lower than those of rats while the white blood cell counts of the toads were significantly higher compared with the rats. There were no significant differences in neutrophil, monocyte, eosinophil and lymphocyte counts of rats when compared with those of the toad.

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Meilūnas, M. "ON THE BLOOD GLUCOSE DYNAMICS MODELLING." Mathematical Modelling and Analysis 3, no. 1 (1998): 136–39. http://dx.doi.org/10.3846/13926292.1998.9637096.

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Mathematical model of the glucose regulation is proposed and discussed. It is based only on the data, which are available in outpatient clinics. This model enables to predict the state of the patients health and to identificate important parameters of patients organism, which are urgent in diabetology.

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Manish, Kumar Jha, Kumari Poonam, and Bharti Madhu. "A Hospital Based Observational Study to Assess the Association of Dengue Serology with Variations in RBC Parameters." International Journal of Current Pharmaceutical Review and Research 16, no. 2 (2024): 185–90. https://doi.org/10.5281/zenodo.10976675.

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Aim: The aim of the present study was to assess the association of dengue serology with variations in RBCparameters.Methods: The present study was conducted in the Department of Pathology. Out of 200 total study populations,100 were dengue positive and 100 were dengue negative.Results: Multiple logistic regression showed thrombocytopenia, leukopenia (ORA = 0.999; p < 0.001), glucoselevel, aspartate aminotransferase and monocytosis as significant parameters in the NS1-only positive group.Similarly, thrombocytopenia, glucose level and aspartate aminotransferase were significant in IgM-only positivepatients. Moreover, thrombocytopenia, leukopenia, glucose, aspartate aminotransferase and lymphopenia wereindependent predictors in both NS1 + IgM positive groups.Conclusion: The study found that certain hematological and biochemical parameters can predict the outcome ofdengue infection, which can assist physicians in the diagnosis and proper patient management. Parameters, suchas thrombocytopenia, AST, hyperglycemia, and leukopenia with monocytosis (in the NS1-only phase);thrombocytopenia, elevated AST, and high blood glucose (in the IgM-only phase); and thrombocytopenia,elevated AST, high blood glucose, and leukopenia with lymphopenia (in the dual-positive/both NS1 + IgM phase),can provide insight into dengue positivity and help with patient management.

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Colares, Elton P., Ioni G. Colares, Adalto Bianchini, and Euclydes A. Santos. "Seasonal variations in blood parameters of the Amazonian manatee, Trichechus inunguis." Brazilian Archives of Biology and Technology 43, no. 2 (2000): 165–71. http://dx.doi.org/10.1590/s1516-89132000000200005.

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Seasonal variations in body weight, food consumption and blood glucose, total lipids, urea, total proteins, albumin and globulins of captive Amazonian manatees, Trichechus inunguis, were determined. Body weight changed significantly along the year, increasing from autumn to spring and decreasing in summer. The mean daily food intake of paragrass remained almost unchanged along the year. Paragrass administered to the manatees showed important variations in crude protein and lipid content along the year. No significant differences in blood parameters were registered between males and females in all seasons. Further, there were no significant differences in blood total proteins, albumin and globulins along the year. On the other hand, significant differences in the mean blood glucose, lipids and urea were registered. An increase in the blood glucose in the spring and summer was observed. Blood urea and lipids levels were positively related to paragrass protein and lipids content. These two correlations suggested that these blood parameters are good indicators of the animal nutritional status in the Amazonian manatee.

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Roengrit, Thapanee, Ruchada Sri-Amad, Nawiya Huipao, Suphawadee Phababpha, and Piyapong Prasertsri. "Impact of Fasting Blood Glucose Levels on Blood Pressure Parameters among Older Adults with Prediabetes." Scientific World Journal 2023 (March 9, 2023): 1–7. http://dx.doi.org/10.1155/2023/1778371.

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Prediabetes mellitus (pre-DM) is defined as blood glucose levels higher than normal but lower than the threshold for diabetes mellitus (DM) diagnosis. Four-limb blood pressure (BP) differences can help identify a significant risk for cardiovascular diseases (CVDs). The current study aimed to determine the importance of BP and the ankle-brachial index (ABI) between two patient groups and the association between fasting blood glucose (FBG) levels and four-limb BP, ABI, interarm BP difference (IAD), and interleg BP difference (ILD). Moreover, the effect of cardiovascular risk factors on the development of pre-DM among older adults was evaluated. The participants were divided into the normal fasting glucose (NFG) and impaired fasting glucose (IFG) groups. Data on physical characteristics, lipid profiles, four-limb BP, ABI, IAD, ILD, and cardiovascular risk factors were assessed. The IFG group had a significantly higher systolic blood pressure (SBP) and pulse pressure than the NFG group ( p < 0.05 ). SBP was significantly positively correlated with FBG levels ( p < 0.05 ). The IFG group had a lower ABI than the NFG group ( p < 0.05 ). However, there was no significant difference in terms of IAD and ILD between the two groups. Furthermore, hypertension (HT), metabolic syndrome (MetS), and dyslipidemia were significantly correlated with a high prevalence of prediabetes ( p < 0.05 ). Individuals with prediabetes had a higher BP than those with normoglycemia. Prediabetes was correlated with HT, MetS, and dyslipidemia.

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Бертова, Юлия Игоревна, and Арина Владимировна Миняева. "Seasonal changes in blood parameters in patients with diabetes mellitus." Herald of Tver State University. Series: Biology and Ecology, no. 1(65) (April 22, 2022): 17–23. http://dx.doi.org/10.26456/vtbio235.

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Исследовали сезонные изменения основных параметров клинического анализа крови и уровня глюкозы в крови у взрослых жителей г. Твери больных сахарным диабетом легкой тяжести. Выявили, что у женщин, больных сахарным диабетом, отсутствуют сезонные изменения уровня глюкозы в крови, а сезонная динамика показателей красной крови не отличается от динамики в контрольной группе. У мужчин, больных сахарным диабетом, сезонное повышение уровня глюкозы в крови сопровождается значительным, по сравнению с контрольной группой, снижением содержания гемоглобина и эритроцитов. We studied how indicators of clinical blood analysis and blood glucose level in diabetic patients change in seasons. It was found that in women with diabetes, the level of glucose in the blood does not change during the seasons, and the seasonal dynamics of red blood indicators does not differ rom those in the control group. In men with diabetes, the seasonal increase in blood glucose levels is accompanied by a significant decrease in hemoglobin and erythrocytes compared to the control group.

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Biro, Katalin, Gergely Feher, Judit Vekasi, Peter Kenyeres, Kalman Toth, and Katalin Koltai. "Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies." Metabolites 11, no. 12 (2021): 806. http://dx.doi.org/10.3390/metabo11120806.

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Diabetes mellitus influences several important hemorheological parameters including blood viscosity, erythrocyte aggregation and deformability. In the present study, 159 type-2 diabetic patients and 25 healthy controls were involved. Patient’s age, body weight, body mass index (BMI), smoking habits, physical activity, history of cardiovascular diseases, current antidiabetic therapy and concomitant medication were recorded. Patients were grouped according to their antidiabetic treatment with insulin, or with one or more of the following antidiabetic drugs: metformin, sulfonylureas, acarbose, or no antidiabetic therapy. Hemorheological measurements (hematocrit, erythrocyte aggregation, plasma fibrinogen, whole blood and plasma viscosity), von Willebrand factor activity, and platelet aggregation measurements were performed. Platelet aggregation was investigated with the method of Born. Plasma viscosity and red blood cell aggregation were significatly higher in diabetes. No significant difference was found in hemorheological parameters between different antidiabetic regimens. Whole blood and plasma viscosity and red blood cell aggregation correlated with glucose levels but not with HbA1C levels. In conclusion, plasma and whole blood viscosity, as well as red blood cell aggregation appear to be associated with concurrent hyperglycemia, but not with the quality of glycemic control or the applied antidiabetic treatment. Platelet aggregation induced by ADP or epinephrine does not seem to be associated with diabetes even at subthreshold doses.

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Fazio, F., S. Marafioti, F. Arfuso, G. Piccione, and C. Faggio. "Comparative study of the biochemical and haematological parameters of four wild Tyrrhenian fish species." Veterinární Medicína 58, No. 11 (2013): 576–81. http://dx.doi.org/10.17221/7139-vetmed.

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A characteristic feature of fish is the wide physiological range of blood parameters and also the large individual variations. The aim of this study was to compare the haematological profile, glucose and lactate levels of four teleost fish species (Gobius niger, Mugil cephalus, Sparus aurata, Dicentrarchus labrax) and to establish the similarities and differences between these species which are widely present in the Tyrrhenian Sea. To this end, glucose, lactate and complete haematological profiles were determined for 25 fish from each species. Statistical analysis confirmed statistical differences in blood parameters among the four species. Our findings show a lower level of glucose and higher levels of lactate, red blood cells and haemoglobin in M. cephalus with respect to the other species. White blood cell and thrombocyte counts have the same trend and result higher in S. aurata. The differences found in this study can be attributed to the feeding behaviour, life style and adaptation of the different fish species to the habitat in which they dwell.

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Fernandez - Rodriguez, Lissett Jeanette, Victor Hugo Bardales-Zuta, Gustavo Adolfo Vásquez-Tirado, Carlos Avalos Alvarado, Eva J. Schaefer, and Julio Hilario-Vargas. "Effect of acute altitude exposure on physiological parameters and glucose metabolism in healthy lowland Peruvians." F1000Research 12 (June 21, 2023): 724. http://dx.doi.org/10.12688/f1000research.134346.1.

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Background: High altitude exposure triggers a series of physiological changes to maintain homeostasis. Although longer-term (days to years) acclimatization processes are well studied, less is known about the physiological changes upon rapid ascent. We took advantage of Peru’s geography to measure the first physiological changes following rapid transport from a low to a high-altitude environment among lowlanders. Methods: Blood glucose, insulin, C-peptide, and salivary cortisol among healthy lowland Peruvians were measured before and after glucose ingestion at 40 m and upon arrival at 3470 m. Resting heart rate, blood oxygen saturation, and blood pressure were also monitored. Results: At high altitude, we find a significant (p<0.05) increase in heart rate and a decrease in blood oxygen saturation and salivary cortisol. Additionally, baseline levels of blood glucose, plasma C-peptide, and cortisol were reduced (p<0.05). Blood glucose, plasma insulin, and plasma C-peptide returned to baseline or below faster at high altitude after glucose ingestion. Conclusions: Although many overlapping environmental and physiological factors are present in the high-altitude environment, the first steps of acclimatization in this population appear to be caused by increased energy expenditure and glucose metabolism to maintain oxygen homeostasis until the longer-term acclimatization mechanisms become more significant.

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Fernandez - Rodriguez, Lissett Jeanette, Victor Hugo Bardales-Zuta, Gustavo Adolfo Vásquez-Tirado, Carlos Avalos Alvarado, Eva J. Schaefer, and Julio Hilario-Vargas. "Effect of acute altitude exposure on physiological parameters and glucose metabolism in healthy lowland Peruvians." F1000Research 12 (November 8, 2023): 724. http://dx.doi.org/10.12688/f1000research.134346.2.

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Soe, Aung Thet, and Kyaw Zwar Htoon. "Metabolic effects of risperidone on patients with psychosis in a tertiary care hospital of Myanmar." GSC Biological and Pharmaceutical Sciences 26, no. 3 (2024): 183–89. https://doi.org/10.30574/gscbps.2024.26.3.0105.

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Background: Risperidone, a second generation antipsychotics, used to treat many psychotic conditions is related with obesity, hyperlipidemia, type 2 diabetes and hypertension. Objective: To find out the metabolic effects of risperidone on patients with psychosis in a tertiary care hospital of Myanmar Method: A hospital based before and after observational study was done on 37 male patients with psychosis who were treated with risperidone. Anthropometric parameters (weight, body mass index, waist hip ratio), clinical parameters (systolic and diastolic blood pressure), biochemical parameters (fasting total cholesterol, fasting high density lipoprotein, fasting low density lipoprotein, fasting triglyceride and fasting blood glucose) were determined before and at one, two, three months of risperidone therapy. Results: After three months of treatment with risperidone at doses ranging from 2 to 6 mg, there were significant alterations in various anthropometric, clinical, and biochemical parameters among participants. Notably, there was a marked increase in body weight from an average of 55.8 kg to 61.6 kg (p<0.001) and in BMI from 20.5 to 22.5 (p<0.001). The waist-hip ratio rose from 0.84 to 0.89 (p<0.001), while systolic blood pressure increased from 119.7 to 125.7 (p=0.001) and diastolic blood pressure from 77.3 to 83.2 (p<0.001). Total cholesterol levels increased from an average of 169.4 to 185.7 (p=0.027), and triglyceride levels increased from 127.2 to 170.7 (p=0.007). However, there were no statistically significant changes observed in high-density lipoprotein, low-density lipoprotein, and fasting blood glucose levels. Conclusion: The results of the study underscore the metabolic effects associated with risperidone therapy, necessitating vigilant monitoring by healthcare providers to manage potential adverse metabolic outcomes effectively.

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Aung, Thet Soe, and Zwar Htoon Kyaw. "Metabolic effects of risperidone on patients with psychosis in a tertiary care hospital of Myanmar." GSC Biological and Pharmaceutical Sciences 26, no. 3 (2024): 183–89. https://doi.org/10.5281/zenodo.11057390.

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Krithika PJ, Mrs. "Non-Invasive Blood Glucose Monitor." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 09, no. 05 (2025): 1–9. https://doi.org/10.55041/ijsrem48901.

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Abstract— The growing need for affordable healthcare solutions has made it possible to create low-cost, portable, and non-invasive monitoring devices. This work introduces a non-invasive health monitoring device based on the ESP32-S3 microcontroller that can measure important vital parameters such as blood oxygen saturation (SpO₂), heart rate, and estimated blood glucose level. The system incorporates the MAX30102 SpO₂ and heart rate photoplethysmography (PPG) sensor, and a 940nm near-infrared emitter-receiver module for optical glucose measurement. The data is presented in real time on a TFT display to provide simplicity of use for both users and non-users. The system is scalable, and the ESP32 wireless capabilities are utilized for possible IoT-based remote health monitoring. With its friendly user interface and portable size, the system promises home care, rural health, and telemedicine applications and presents an appropriate preventive healthcare instrument. Keywords—Non-Invasive monitoring, blood glucose estimation, ESP32-S3, MAX30102, photoplethysmography, SpO₂, heart rate, near-infrared sensor, TFT display, wearable health devices, telemedicine, IoT healthcare.

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Leybaert, Luc. "Neurobarrier Coupling in the Brain: A Partner of Neurovascular and Neurometabolic Coupling?" Journal of Cerebral Blood Flow & Metabolism 25, no. 1 (2005): 2–16. http://dx.doi.org/10.1038/sj.jcbfm.9600001.

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Neurovascular and neurometabolic coupling help the brain to maintain an appropriate energy flow to the neural tissue under conditions of increased neuronal activity. Both coupling phenomena provide us, in addition, with two macroscopically measurable parameters, blood flow and intermediate metabolite fluxes, that are used to dynamically image the functioning brain. The main energy substrate for the brain is glucose, which is metabolized by glycolysis and oxidative breakdown in both astrocytes and neurons. Neuronal activation triggers increased glucose consumption and glucose demand, with new glucose being brought in by stimulated blood flow and glucose transport over the blood-brain barrier. Glucose is shuttled over the barrier by the GLUT-1 transporter, which, like all transporter proteins, has a ceiling above which no further stimulation of the transport is possible. Blood-brain barrier glucose transport is generally accepted as a nonrate-limiting step but to prevent it from becoming rate-limiting under conditions of neuronal activation, it might be necessary for the transport parameters to be adapted to the increased glucose demand. It is proposed that the blood-brain barrier glucose transport parameters are dynamically adapted to the increased glucose needs of the neural tissue after activation according to a neurobarrier coupling scheme. This review presents neurobarrier coupling within the current knowledge on neurovascular and neurometabolic coupling, and considers arguments and evidence in support of this hypothesis.

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Simonis-Bik, Annemarie M. C., Elisabeth M. W. Eekhoff, Michaela Diamant, et al. "The Heritability of HbA1c and Fasting Blood Glucose in Different Measurement Settings." Twin Research and Human Genetics 11, no. 6 (2008): 597–602. http://dx.doi.org/10.1375/twin.11.6.597.

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AbstractIn an extended twin study we estimated the heritability of fasting HbA1c and blood glucose levels. Blood glucose was assessed in different settings (at home and in the clinic). We tested whether the genetic factors influencing fasting blood glucose levels overlapped with those influencing HbA1c and whether the same genetic factors were expressed across different settings. Fasting blood glucose was measured at home and during two visits to the clinic in 77 healthy families with same-sex twins and siblings, aged 20 to 45 years. HbA1c was measured during the first clinic visit. A 4-variate genetic structural equation model was used that estimated the heritability of each trait and the genetic correlations among traits. Heritability explained 75% of the variance in HbA1c. The heritability of fasting blood glucose was estimated at 66% at home and lower in the clinic (57% and 38%). Fasting blood glucose levels were significantly correlated across settings (0.34 <r< 0.54), mostly due to a common set of genes that explained between 53% and 95% of these correlations. Correlations between HbA1c and fasting blood glucoses were low (0.11 <r< 0.23) and genetic factors influencing HbA1c and fasting glucose were uncorrelated. These results suggest that in healthy adults the genes influencing HbA1c and fasting blood glucose reflect different aspects of the glucose metabolism. As a consequence these two glycemic parameters can not be used interchangeably in diagnostic procedures or in studies attempting to find genes for diabetes. Both contribute unique (genetic) information.

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Wu, Hui, Michael Wu, Yi Chen, Carolyn A. Allan, David J. Phillips, and Mark P. Hedger. "Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes." Experimental Diabetes Research 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/410579.

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Aims. Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined.Methods. Blood was taken from fasted participants (34 males; 58 females; 50–75 years) with diabetes or during an oral glucose tolerance test (OGTT). Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein.Results. Serum levels of activin A (93.3 ± 27.0 pg/mL, mean ± SD), B (81.8 ± 30.8 pg/mL), or follistatin (6.52 ± 3.15 ng/mL) were not different (P>0.05) between subjects with normal OGTT (n=39), impaired glucose tolerance and/or fasting glucose (n=17), or T2D (n=36). However, activin A and/or activin B were positively correlated with parameters of insulin resistance and T2D, including fasting glucose (P<0.001), fasting insulin (P=0.02), glycated hemoglobin (P=0.003), and homeostasis model assessment of insulin resistance (HOMA-IR;P<0.001). Follistatin was positively correlated with HOMA-IR alone (P=0.01).Conclusions. These data indicate that serum measurements of activin A, B, or follistatin cannot discriminate risk for T2D in individual patients, but the activins display a positive relationship with clinical parameters of the disease.

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DITTAKAVI, SARMA S., and DHANJOO N. GHISTA. "GLUCOSE TOLERANCE TESTS MODELING & PATIENT-SIMULATION FOR DIAGNOSIS." Journal of Mechanics in Medicine and Biology 01, no. 02 (2001): 193–223. http://dx.doi.org/10.1142/s0219519401000258.

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Diabetes mellitus is a heterogeneous clinical syndrome characterized by hyperglycemia and long-term specific complications: retinopathy, neuropathy, nephropathy, and cardiomyopathy. Automatic neuropathy leads to visceral denervation producing a variety of clinical abnormalities: cardiac and respiratory dysrythaemias, gastrointestinal motility disorders, urinary bladder dysfunction and impotence. Diabetes mellitus is a leading cause of blindness; renal failure and limb amputation all over the world. The need to detect diabetic risk factors and treat organ disorders and complications associated with diabetes provides the impetus for us to develop the technology for assessment of diabetes, its etiology and severity, as well as for assessing the efficacy of pharmacological therapy. This paper concerns: (i) modelling of blood-glucose regulation and tolerance-testing, (ii) demonstrating patient-simulation of the blood-glucose regulatory models, by means of which the model parameters can be evaluated and related to physiological parameters, and (iii) elucidating how the glucose-regulatory system model's pole-zero representation and the blood glucose-insulin transfer-function can explain the blood glucose response data in intravenous and oral glucose tolerance tests. An easy-to-implement simple clinical-application method is developed to simulate the response of the blood-glucose regulatory model in diabetic patients during intravenous glucose tolerance test and to estimate the model parameters, which can then enable differential diagnosis of diabetes and its severity as well as in early detection of risk-to-diabetes. In the oral glucose-tolerance test, the role of the gut is to facilitate transport of glucose across the intestinal wall. The Michaelis-Menten equation, describing this enzyme-catalyzed reaction rate, can be employed to conclude that the intestinal glucose absorption rate into the blood-compartment from the gut during the oral glucose-tolerance test is constant, almost resembling a rectangular pulse Nevertheless, we have formulated a new rate-control model to simulate the oral glucose-tolerance test data, by means of the response-function of a second-order system of a single-compartment (consisting of the gut and the blood-glucose pool), with the oral glucose-bolus as the impulse-input. We have also demonstrated application of this rate-control model to patients undergoing oral glucose-tolerance test, to evaluate the model parameters. By categorizing the ranges of these parameters for normals and diabetics (varying from mild to severe), we can reliably apply this model and procedure clinically.

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Choe, J. H., M. H. Choi, Y. C. Ryu, et al. "Correlations among various blood parameters at exsanguination and their relationships to pork quality traits." Animal Production Science 55, no. 5 (2015): 672. http://dx.doi.org/10.1071/an13424.

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The objectives of this study were to investigate the correlations between various blood parameters compared with cortisol and lactate levels under the standard pre-slaughter procedure and handling conditions and to assess their potential as indicators of pork quality traits. Despite there being no additional pre-slaughter stress treatment, there is considerable variation in blood parameters at exsanguination. Serum cortisol and blood lactate levels, widely used indicators of stress, were positively correlated with blood glucose and electrolytes, such as calcium, potassium and sodium. Moreover, these parameters were significantly correlated with a rapid rate of early postmortem glycolysis and reduced water-holding capacity. In particular, blood lactate and glucose levels significantly differed between porcine quality classes. However, other blood parameters including electrolytes did not significantly differ between quality classes though they significantly correlated with pork quality traits. Therefore, serum cortisol, blood lactate and glucose have potential as indicators of the rate and extent of postmortem metabolism and ultimate pork quality under the standard procedure and handling conditions of pre-slaughter.

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P. Dzhelebov and K. Trifonova. "POLOXAMER 407-INDUCED CHRONIC HYPERLIPIDEMIA IS NOT ASSOCIATED WITH DISORDERS OF BLOOD GLUCOSE LEVELS." TRAKIA JOURNAL OF SCIENCES 23, no. 1 (2025): 6. https://doi.org/10.15547/tjs.2025.01.002.

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PURPOSE: The aim of the study was to evaluate the effects of chronic poloxamer 407 treatment on some parameters of lipid and glucose metabolism in a rat experimental model and to test the potential of this treatment to induce a condition similar to diabetes type 2. METHODS: The following parameters of lipid and glucose metabolism were measured: blood concentration of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, triglycerides and glucose concentrations following intravenous glucose tolerance test (IVGTT). Twelve male Wistar rats were used in the study. Rats were divided into two groups: 1) group C (control group) – rats from this group received no treatment during the entire experimental period; 2) group P (poloxamer group) – rats from this group were treated daily with poloxamer for a period of one month after which parameters of lipid and glucose metabolism were measured in both groups. RESULTS: Chronic poloxamer treatment induced significant changes in lipid metabolism parameters but did not affect glucose metabolism parameters. CONCLUSIONS: A 30 days experimental poloxamer treatment in rats is not associated with disorders of blood glucose levels.

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Gutiérrez, Milton Milciades Cortez, and Lauriano Portilla Sandoval. "Mathematical model of glucose concentration in blood plasma." Brazilian Journal of Development 9, no. 12 (2023): 32062–81. http://dx.doi.org/10.34117/bjdv9n12-101.

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An analysis is made of the dynamic properties of the glucose, glucagon and other hormones (insulin) concentration system in the blood; The estimation of parameters was done by non-linear least squares for glucose and for the stability of the system the method of eigenvalues, the response of the system was also obtained using transfer functions with unit step input. As a result of the estimation of parameters and simulation of the system, it allowed us to observe that this control strategy by least squares and transfer functions obtained similar results.

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Gilmiyarova, F. N., N. A. Kolotyeva, O. A. Gusyakova, N. S. Nefedova, E. A. Shahnovich, and N. I. Gergel. "Key parameters of carbohydrate metabolism in healthy people with different AB0 blood groups." Kazan medical journal 94, no. 5 (2013): 672–74. http://dx.doi.org/10.17816/kmj1916.

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Aim. To study the particularities of metabolism associated with AB0 system blood groups by examination of carbohydrate exchange serum parameters. Methods. 446 healthy subjects with different blood groups were examined: 0 (I) blood group - 29.6%, A (II) - 31.8%, B (III) - 24.3%, AB (IV) - 14.3%. The blood group was defined by direct agglutination test in all subjects, piruvate, lactate, glucose, cortisol and insulin serum levels, lactatdehydrogenase and α-аmylase activity was defined using an automatic biochemical analyzer. Results. Group specific features of carbohydrate metabolism in subjects with different blood groups were revealed. In subjects with 0 (I) blood group the lowest glucose and insulin serum levels, the highest amylase activity and piruvate and lactate blood levels were characteristic; in subjects with A (II) blood group - highest level of insulin and cortisol, low lactate levels; in subjects with B (III) blood group - maximal lactatdehydrogenase and minimal amylase activity, high piruvate and lactate blood levels; in subjects with AB (IV) blood group - highest level of glucose, low lactatdehydrogenase and amylase activity, lowest lactate and piruvate blood levels were revealed. Conclusion. The particularities of molecular processes might be associated with blood group and predispose to different health conditions. The features of the metabolic profile of patients with different blood groups are the rationale for individualization of personal standards for each person that might reasonably be considered in clinical practice.

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Kavya, K. S., R. S. Kulkarni, and M. Jadesh. "Some Blood Biochemical Changes in Response to Saline Exposure in the Fresh Water Fish, Notopterus notopterus (Pallas)." International Letters of Natural Sciences 49 (November 2015): 19–23. http://dx.doi.org/10.18052/www.scipress.com/ilns.49.19.

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The changes in some blood biochemical parameters were studied in the freshwater fish N. notopterus under saline exposure for a longer period of 30 days. The blood biochemical parameters are glucose, protein, triglycerides and cholesterol. All these parameters exhibited increased level except of blood glucose which remained unchanged as observed after the termination of saline exposure. Thus it indicates that although fish survives and able to tolerate extreme saline condition as there was no mortality during the exposure period. The increase of blood biochemical parameters can be considered as a kind of saline stress response particularly on lipid derivatives.

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Kavya, K. S., R. S. Kulkarni, and M. Jadesh. "Some Blood Biochemical Changes in Response to Saline Exposure in the Fresh Water Fish, Notopterus notopterus (Pallas)." International Letters of Natural Sciences 49 (November 24, 2015): 19–23. http://dx.doi.org/10.56431/p-rh504p.

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Barash, Murad, Iliev Petar, Prelezov Petyo, et al. "A STUDY ON SOME BIOCHEMICAL PARAMETERS AND BLOOD MINERALS IN LAMBS WITH EXPERIMENTALLY INDUCED HAEMONCHUS CONTORTUS INFECTION." TRADITION AND MODERNITY IN VETERINARY MEDICINE 3, no. 2 (2018): 86–89. https://doi.org/10.5281/zenodo.1489507.

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This study was focused on changes of some minerals and blood metabolites during experimentally induced H. contortus infection in lambs. A total of 12 animals were included in the study and were divided into experimental (n=6) and control (n=6) groups. The lambs from experimental group were orally inoculated with 4000 infective H. contortus larvae (L3) by placing a probe. Blood parameters (calcium, phosphorus, magnesium, creatitine, glucose, total bilirubin, urea and alkaline phosphatase) were monitored on post infection days 0 and 21. The most pronounced changes occurred in urea and alkaline phosphatase levels, which increased significantly on day 21 (p<0.05) and reached values of 12.17±0.24 mmol/L and 334.17±32.3 U/L, respectively. The concentration of urea in experimental group was higher by 46.82% compared to control group. Alkaline phosphatase activity was also increased by 55.07% vs. control group. Mild changes occured in plasma concentrations of calcium, phosphorus, magnesium, creatinine, glucose and total bilirubin but were not considered significant throughout the experiment.

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Hu, Ke, Bing-Jing Lv, Hang-Jia Zuo, et al. "Retinal microcirculation changes in prediabetic patients with short-term increased blood glucose using optical coherence tomography angiography." World Journal of Radiology 16, no. 9 (2024): 407–17. http://dx.doi.org/10.4329/wjr.v16.i9.407.

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BACKGROUND Retinal microcirculation alterations are early indicators of diabetic microvascular complications. Optical coherence tomography angiography (OCTA) is a noninvasive method to assess these changes. This study analyzes changes in retinal microcirculation in prediabetic patients during short-term increases in blood glucose using OCTA. AIM To investigate the changes in retinal microcirculation in prediabetic patients experiencing short-term increases in blood glucose levels using OCTA. METHODS Fifty volunteers were divided into three groups: Group 1 [impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)], Group 2 (both IFG and IGT), and a control group. Retinal microcirculation parameters, including vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) metrics, were measured using OCTA. Correlations between these parameters and blood glucose levels were analyzed in both the fasting and postprandial states. RESULTS One hour after glucose intake, the central VD (P = 0.023), central PD (P = 0.026), and parafoveal PD (P < 0.001) were significantly greater in the control group than in the fasting group. In Group 1, parafoveal PD (P < 0.001) and FAZ circularity (P = 0.023) also increased one hour after glucose intake. However, no significant changes were observed in the retinal microcirculation parameters of Group 2 before or after glucose intake (P > 0.05). Compared with the control group, Group 1 had a larger FAZ area (P = 0.032) and perimeter (P = 0.018), whereas Group 2 had no significant differences in retinal microcirculation parameters compared with the control group (P > 0.05). Compared with Group 1, Group 2 had greater central VD (P = 0.013) and PD (P = 0.008) and a smaller FAZ area (P = 0.012) and perimeter (P = 0.010). One hour after glucose intake, Group 1 had a larger FAZ area (P = 0.044) and perimeter (P = 0.038) than did the control group, whereas Group 2 showed no significant differences in retinal microcirculation parameters compared with the control group (P > 0.05). Group 2 had greater central VD (P = 0.042) and PD (P = 0.022) and a smaller FAZ area (P = 0.015) and perimeter (P = 0.016) than Group 1. At fasting, central PD was significantly positively correlated with blood glucose levels (P = 0.044), whereas no significant correlations were found between blood glucose levels and OCTA parameters one hour after glucose intake. CONCLUSION A short-term increase in blood glucose has a more pronounced effect on retinal microcirculation in prediabetic patients with either IFG or IGT.

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Abougarair, Ahmed J., Mosab JA Abujarir, and Hana Tarek Tilamon. "Artificial pancreas control using optimized fuzzy logic based genetic algorithm." International Robotics & Automation Journal 9, no. 2 (2023): 89–97. http://dx.doi.org/10.15406/iratj.2023.09.00270.

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The aim of this paper is to develop an artificial pancreas that can automate the process of monitoring blood glucose levels and administering insulin to diabetic patients. The device incorporates a fuzzy controller that is optimized through a genetic algorithm and designed using MATLAB. The system comprises three key components: a continuous glucose monitoring (CGM) system, an insulin pump, and the fuzzy controller. The CGM measures blood glucose levels in real-time, and the insulin pump administers insulin doses to maintain blood glucose levels within a specific range. The fuzzy controller adjusts the insulin delivery rate based on the patient's blood glucose levels and their target range. To enhance the system's performance, a genetic algorithm is used to fine-tune the parameters of the fuzzy controller, seeking the optimal set of parameters that minimize the difference between the patient's blood glucose levels and the desired target range. The system is implemented in MATLAB, and simulation results indicate its effectiveness in maintaining blood glucose levels within the desired target range, reducing the risk of hypoglycemia and hyperglycemia. In summary, the proposed artificial pancreas system provides an effective automated solution for monitoring blood glucose levels and administering insulin to diabetic patients, with the fuzzy controller and genetic algorithm optimization enhancing the system's performance.

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Zibolka, Juliane, Anja Wolf, Lisa Rieger, et al. "Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice." International Journal of Molecular Sciences 21, no. 9 (2020): 3168. http://dx.doi.org/10.3390/ijms21093168.

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Cannabinoids are known to influence hormone secretion of pancreatic islets via G protein-coupled cannabinoid receptor type 1 and 2 (CB1 and CB2). The present study was designed to further investigate the impact of cannabinoid receptors on the parameters involved in insulin secretion and blood glucose recognition. To this end, CB1 and CB2 receptor knockout mice (10–12 week old, both sexes) were characterised at basal state and compared to wild-type mice. The elimination of cannabinoid receptor signalling resulted in alterations of blood glucose concentrations, body weights and insulin levels. Changes were dependent on the deleted receptor type and on the sex. Analyses at mRNA and protein levels provided evidence for the impact of cannabinoid receptor deficiency on the glucose sensing apparatus in the pancreas. Both receptor knockout mouse lines showed decreased mRNA and protein amounts of glucose transporters Glut1 and Glut2, combined with alterations in immunostaining. In addition, pancreatic glucokinase expression was elevated and immunohistochemical labelling was modified in the pancreatic islets. Taken together, CB1 and CB2 signalling pathways seem to influence glucose sensing in β-cells by affecting glucose transporters and glucokinase. These alterations were more pronounced in CB2 knockout mice, resulting in higher blood glucose and lower plasma insulin levels.

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Jasim, Wesam M., and Yousif I. Al Mashhadany. "Diabetics blood glucose control based on GA-FOPID technique." Bulletin of Electrical Engineering and Informatics 10, no. 1 (2021): 516–23. http://dx.doi.org/10.11591/eei.v10i1.2715.

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In this paper, an optimized Fractional Order Proportional, Integral, Derivative based Genetic Algorithm GA-FOPID optimization technique is proposed for glucose level normalization of diabetic patients. The insulin pump with diabetic patient system used in the simulation is the Bergman minimal model, which is used to simulate the overall system. The main purpose is to obtain the optimal controller parameters that regulate the system smoothly to the desired level using GA optimization to find the FOPID parameters. The next step is to obtain the FOPID controller parameters and the traditional PID controller parameters normally. Then, the simulation output results of using the proposed GA-FOPID controller was compared with that of using the normal FOPID and the traditional PID controllers. The comparison shows that all the three controllers can regulate the glucose level but the use of GA-FOPID controller was outperform the use of the other two controllers in terms of speed of normalization and the overshoot value.

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Wesam, M. Jasim, and I. Al Mashhadany Yousif. "Diabetics blood glucose control based on GA-FOPID technique." Bulletin of Electrical Engineering and Informatics 10, no. 1 (2021): 516–23. https://doi.org/10.11591/eei.v10i1.2715.

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Bilge, Ayşegül, Hatice Şeyma Akça, and Abuzer Özkan. "Comparison of blood gas analysis parameters, biochemical tests and hematological parameters in geriatric patients admitted to the emergency department." Journal of Clinical Medicine of Kazakhstan 20, no. 2 (2023): 60–64. http://dx.doi.org/10.23950/jcmk/13145.

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Aim: The primary aim is to compare blood gas parameters (sodium, potassium, glucose, hemoglobin, hematocrit) with biochemical test and hospital hemogram results and thus to investigate the compatibility of blood gas estimation with other laboratory tests in geriatrics. The secondary aim is to compare the effects of these parameters on patient mortality. Material and methods: Patients over the age of 65 who applied to the emergency department were included in our retrospective study. Statistical Package for Social Sciences (SPSS Inc., version 20.0; Chicago, IL) was used for statistical analyzes applying to the emergency department. Statistical significance was accepted as p&lt;0.05. Results: 102 patients were included in our study and 51.97% were male. 9.8% of our patients died. The diagnostic test performance analyzes of BG (blood gas) hemoglobin, hemoglobin, BG hematocrit, hematocrit, BG glucose, glucose, BG sodium, sodium, BG potassium, potassium in predicting mortality revealed with the AUC(area under curve) value being calculated as unsuccessful for BG hemoglobin, hemoglobin, BG hematocrit and hematocrit (AUC value: 0.47, 0.45, 0.46, 0.50). AUC (area under curve) value being calculated as weak for BG glucose, glucose and BG sodium (AUC value: 0.64, 0.61, 0.63 respectively). AUC value being calculated as medium for sodium (AUC value: 0.71). Conclusion: There is no superiority of blood gas parameters over hematological and biochemical parameters in predicting mortality in the geriatric patient group. However, blood gas parameters can be used in patient management as they correlate with other laboratory tests.

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Zyukov, Oleg L., Оlena О. Оshyvalova, and Oksana K. Biloshytska. "MATHEMATICAL MODEL FOR PREDICTING FASTING BLOOD GLUCOSE LEVEL IN DIABETES MELLITUS PATIENTS." Wiadomości Lekarskie 76, no. 10 (2023): 2295–301. http://dx.doi.org/10.36740/wlek202310125.

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The aim: To substantiate the use of data on patients’ lifestyle, parameters of blood glucose, heart rate, blood pressure and bread units to build a mathematical model for predicting fasting blood glucose level in diabetes mellitus patients to improve existing measures for diabetes prevention. Materials and methods: An open database consisting of the studied parameters of 359 people was used in the research. The linear regression method was used to predict fasting blood glucose level in diabetes mellitus patients. The statistical software IBM SPSS Statistics Version 23 was chosen for calculations. Results: To calculate the coefficients of the linear regression equation, stepwise elimination of parameters was chosen. The analysis of the coefficients of influence of independent variables on dependent showed that the greatest effect on the change in glucose level had value of consumed bread units. The model for women diagnosed with type 2 diabetes showed the highest accuracy. Conclusions: Mathematical modeling made it clear that any malnutrition or health disorders can lead to a significant change in glucose levels. The obtained models consist of a number of parameters, some of which might depend on the presence of concomitant diseases. Further studies should focus on the optimal combination of various parameters taking into account methods of treating comorbidities.

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George, Bakari Gaymary, Mushi James Richard, and Temba Benigni Alfred. "Body Weight, Hematological and Biochemical Parameters of Wistar Albino Rats Fed with Chia Seed Concentrate." European Journal of Medicinal Plants 34, no. 11 (2023): 10–19. http://dx.doi.org/10.9734/ejmp/2023/v34i111167.

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Chia seeds are among commonly used natural remedies to control obesity, diabetes mellitus and cardiovascular diseases. A research was conducted to evaluate the effects of chia seeds on Body weights, hematological parameters, blood glucose, and lipid profiles in Wistar rats. In the current study, Wistar rats were fed on chia seed powder mixed with broiler chicken feed mash at concentrations of 0, 5, 10, 15 and 20%. Body weights, hematological parameters, blood glucose, and lipid profiles were monitored for 28 days. Results indicate that for the treated groups, there was significant increase in white blood cell (WBC) count and lymphocytes in a dose dependent manner (R2 = 0.87; p = 0.032). Plasma glucose and lipid profiles also decreased significantly in an dose dependent manner, whereby, for glucose, group 4 rats-decreased from 138.5 ± 0.8 to 80.3 ± 12.9 mg/dL from day 0 to day 28 of treatment. The results show no significant difference on weight gain in chia treated groups compared to control group. There were no significant variations in the other hematological parameters. In conclusion, findings in this study illustrated that chia seeds can be the good candidate for controlling blood glucose, lipid profiles and improving hematological parameters and also body weight in animals.

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Wang, Yan Nian, and Bang An. "The Research Least Squares Based on Ar Model of Glucose Prediction." Advanced Materials Research 971-973 (June 2014): 284–87. http://dx.doi.org/10.4028/www.scientific.net/amr.971-973.284.

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Diabetes Clinical Research important task is to monitor and prevent the occurrence of high / low blood sugar events. Glucose monitoring system (Continous Glucose Monitoring System, CGMS) is used clinically in recent years gradually new blood glucose monitoring system, by measuring the concentration of glucose in interstitial fluid glucose fluctuations throughout the day to indirectly reflect the whole picture. It can be 30 minutes early to predict blood glucose levels as well as low blood sugar warning. Based on time-series modeling techniques, with blood glucose levels for non-stationary paper with improved self-regression model (AR) on blood glucose prediction. And the order of the model parameters were determined by the least squares method and adaptive AIC criteria. The results show that the algorithm can be based on time series modeling real-time and accurate display changes in blood glucose levels, while forecasting and early warning of low blood sugar glucose results showed good performance.

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Shrestha, Sneha, Sushant Pokhrel, Anjali Poudel, et al. "Implication of Salivary Biochemical Parameters for Diagnosis and Prognosis of Type 2 Diabetes Mellitus." International Journal of Analytical Chemistry 2022 (August 10, 2022): 1–8. http://dx.doi.org/10.1155/2022/1781613.

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Background. Clinical laboratory diagnosis and prognosis for diabetes mellitus is performed using blood as a major specimen; however, saliva may represent as an alternative noninvasive specimen of choice. This study aims to evaluate salivary biochemical parameters in diabetic and healthy individuals to substantiate saliva’s role in the diagnosis and prognosis of type 2 diabetes mellitus (T2DM). Methods. This case-control study included 150 T2DM patients and 150 apparently healthy individuals. Socio-demographic data and anthropometric measurements were recorded using a standard questionnaire. Correlation between salivary and blood levels for each parameter was determined using Pearson correlation. Linear regression was performed to estimate the blood levels of the parameters from their salivary levels. Receiver operating characteristics (ROC) analysis was done to determine the diagnostic ability of salivary glucose and establish a sensitivity, specificity, and cut-off value. Results. Salivary glucose, TC, LDL-C, urea, and creatinine were significantly higher in people with diabetes than in the control population ( p < 0.05 ). A significant positive correlation was found between salivary and blood parameters including glucose, TC, TG, LDL-C, urea, and creatinine except for HDL-C in both case and control groups. The linear relationship for each parameter, except glucose in case population and HDL-C in case, control, and the total population was observed between blood and saliva. ROC analysis gave a cut-off value of 1.9 mg/dl for salivary glucose with 71.4% sensitivity and 72.3% specificity. Conclusion. Salivary estimation significantly reflects the blood parameters in this study, indicating that saliva can be a noninvasive specimen for the diagnosis and prognosis of T2DM.

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Elbaeva, A. D., and A. D. Elbaev. "DEVELOPMENT OF A MECHATRONIC SYSTEM FOR CONTROL OF BIOLOGICAL PARAMETERS OF BLOOD." Quality. Innovation. Education, no. 4 (2022): 60–68. http://dx.doi.org/10.31145/1999-513x-2022-4-60-68.

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The development of instruments and control devices in medicine is aimed at achieving the quality of complex manipulation operations. The use of mechatronic principles for the construction of automatic devices ensures the creation of new methods and instruments for laboratory analyses. We have developed a mechatronic system of the device for a noninvasive method for determining the concentration of blood glucose on the basis of modeling the correlation between systemic hemodynamic parameters and biological parameters of blood. A functional multivariate analysis was carried out, a computer program was compiled, and mathematical regression formulas were obtained for calculating the level of blood glycaemia based on blood pressure indicators. The mechatronic system includes functional blocks for measuring blood pressure parameters, a control microcontroller for calculating and monitoring blood glucose levels in accordance with the application program.The system is implemented in the form of a noninvasive device «Omelon B-2», which provides the transfer of indicators to the display of the device, communication with the base computer of the system, analysis of the results and creation of a database. The blood glucose measurement range is from 2 to 20 mmol/l. The relative error of the analysis in comparison with laboratory parameters is 17-22%.

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Matveeva, S. A. "ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS." Cardiovascular Therapy and Prevention 12, no. 5 (2013): 29–33. http://dx.doi.org/10.15829/1728-8800-2013-5-29-33.

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Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.

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Polat, U., H. Gencoglu, and I. I. Turkmen. "The effects of partial replacement of corn silage on biochemical blood parameters in lactating primiparous dairy cows." Veterinární Medicína 54, No. 9 (2009): 407–11. http://dx.doi.org/10.17221/72/2009-vetmed.

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The aim of this experiment was to investigate the effects of partial replacement of corn silage with long alfalfa hay and/or coarse chopped wheat straw on biochemical parameters in late lactating Holstein primiparous dairy cows. Twelve late lactating Holstein primiparous cows including four cows equipped with a rumen cannula, averaging 210 ± 20 days in milk and weighing 575 ± 50 kg were randomly assigned in a 4 × 4 Latin square design. During each of four 21-days periods, cows were fed four total mixed diets that were varied in the forage sources: (1) 50% corn silage (CS), (2) 35% corn silage + 15% wheat straw (CSW), (3) 35% corn silage + 15% alfalfa hay (CSA), (4) 25% corn silage + 10% wheat straw + 15% alfalfa hay (CSWA). At the end of the feeding period, blood samples were taken from jugular vein. Serum glucose, total protein, albumin/globulin, creatinine, creatinin kinase, urea and uric acid levels were determined by using Auto Technicon DAX 72 autoanalyzer. While serum glucose, albumin, globulin, urea, uric acid and creatinine kinase activity were not found significantly different among groups, serum total protein (between CS and CSA, CS and CSWA) and creatinine (between CSA and CSWA) levels had statistical significance at the levels of P < 0.05. It is concluded that rumen propionate and ammonia levels may be good indicator for glucose and BUN, respectively.

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Ng, Eric, Jaycee M. Kaufman, Lennaert van Veen, and Yan Fossat. "A parsimonious model of blood glucose homeostasis." PLOS Digital Health 1, no. 7 (2022): e0000072. http://dx.doi.org/10.1371/journal.pdig.0000072.

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The mathematical modelling of biological systems has historically followed one of two approaches: comprehensive and minimal. In comprehensive models, the involved biological pathways are modelled independently, then brought together as an ensemble of equations that represents the system being studied, most often in the form of a large system of coupled differential equations. This approach often contains a very large number of tuneable parameters (> 100) where each describes some physical or biochemical subproperty. As a result, such models scale very poorly when assimilation of real world data is needed. Furthermore, condensing model results into simple indicators is challenging, an important difficulty in scenarios where medical diagnosis is required. In this paper, we develop a minimal model of glucose homeostasis with the potential to yield diagnostics for pre-diabetes. We model glucose homeostasis as a closed control system containing a self-feedback mechanism that describes the collective effects of the physiological components involved. The model is analyzed as a planar dynamical system, then tested and verified using data collected with continuous glucose monitors (CGMs) from healthy individuals in four separate studies. We show that, although the model has only a small number (3) of tunable parameters, their distributions are consistent across subjects and studies both for hyperglycemic and for hypoglycemic episodes.

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Perlee, Desirée, Klaas Henk van der Steege, and Gijs den Besten. "The effect of drone transport on the stability of biochemical, coagulation and hematological parameters in healthy individuals." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 11 (2021): 1772–76. http://dx.doi.org/10.1515/cclm-2021-0513.

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Abstract Objectives Transport of blood tubes is mainly by car or pneumatic transport. The transportation of blood tubes by drones is a novel approach for rapid transportation of blood tubes over long distances. However, limited data on the stability of biochemical, coagulation and hematological parameters is available after transport of blood tubes by drone. Methods To investigate the effect of drone transport on the stability of blood parameters, four test flights were performed. Blood was drawn from 20 healthy individuals and 39 of the most frequently measured blood parameters were compared between 4 groups; immediate measurement (control), late measurement, transport by car and transport by drone. Total allowable error (TAE) of the EFLM Biological Variation Database was used to determine the clinical relevance of significant differences. Results The majority of blood parameters were not affected by drone transport. Eight of the measured parameters showed significant differences between all the groups; glucose, phosphate, potassium, chloride, hemoglobin, platelet count, activated partial thromboplastin time (APTT) and lactate dehydrogenase (LD). A clinically relevant increase for LD after transport and a decrease for glucose values in time and after transport compared with the control group was shown. Conclusions Transportation of blood tubes from healthy individuals by drones has a limited clinically relevant effect. From the 39 investigated blood parameters only LD and glucose showed a clinically relevant effect.

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Zhang, Rui, and Boru Feng. "Efficacy and safety of a combination of shuangdan mingmu capsules and laser therapy for diabetic retinopathy, and its effect on blood glucose indices and quality of life of patients." Tropical Journal of Pharmaceutical Research 21, no. 2 (2022): 417–23. http://dx.doi.org/10.4314/tjpr.v21i2.27.

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Purpose: To investigate the efficacy and safety of a combination of Shuangdan Mingmu capsules andlaser therapy in diabetic retinopathy (DR), as well as on blood glucose index and quality of life.Methods: One hundred and twenty DR patients admitted to Zhenba County Peoples Hospital, Shaanxi were assigned equally to 2 groups: A and B. Retinal laser photocoagulation was performed for group B patients, while Shuangdan Mingmu capsules were given to group A, in addition to laser treatment. Ophthalmic parameters, blood glucose indices, ultrasonic indices, platelet parameters, quality of life, and incidence of adverse drug reactions (ADR) were determined and compared between groups A andB.Results: Following treatment, group A had significantly better ophthalmic parameters, blood glucose indices and platelet parameters (p < 0.05); better ultrasonic indices and quality of life (p < 0.001), and lower ADRs (p < 0.05) than group B.Conclusion: The combination of Shuangdan Mingmu capsules and laser therapy effectively cures ocular lesions, controls blood glucose, and lowers ADR in DR patients. Therefore, the combined therapy should be further investigated for the management of diabetic retinopathy.

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Ajlaan, S. K., L. M. Al Naama, and M. M. Al Naama. "Correlation between normal glucose-6-phosphate dehydrogenase level and haematological parameters." Eastern Mediterranean Health Journal 6, no. 2-3 (2000): 391–95. http://dx.doi.org/10.26719/2000.6.2-3.391.

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The study involved 143 individuals and aimed to correlate normal glucose-6-phosphate dehydrogenase [G6PD]level with haematological parameters. A statistically significant negative correlation was found between G6PD level and haemoglobin, packed cell volume, red blood cell count, mean corpuscular haemoglobin and mean corpuscular volume. A statistically significant positive correlation was found between G6PD level and white blood cell count and reticulocyte count, but no significant correlation was found between G6PD level and mean corpuscular haemoglobin concentration. The negative correlation between G6PD level and haemoglobin suggests that anaemic people have higher G6PD levels than normal individuals. The positive correlation between G6PD level and white blood cell count indicates that white blood cells may play an important role in contributing to G6PD level

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