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Journal articles on the topic 'Blood lactate'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Jacobs, Ira. "Blood Lactate." Sports Medicine 3, no. 1 (1986): 10–25. http://dx.doi.org/10.2165/00007256-198603010-00003.

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2

Nikseresht, Asghar, Iman Yabande, Karamatollah Rahmanian, and Abdolreza Sotoodeh Jahromi. "Blood lactate level in Elite boy swimmers after lactate tolerance exercise test." Biomedical Research and Therapy 4, no. 05 (2017): 1318. http://dx.doi.org/10.15419/bmrat.v4i05.170.

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Introduction: To avoid injuries during high-intensity sports training, it is important to recognize conditions of bodily consumption and production of adequate energy; exercise increases the concentration of the blood lactate. This paper is an attempt to compare pre and post lactate tolerance exercise test - blood lactate concentrations - of elite boy swimmers. Methods: Blood lactates are measured by an enzymatic method on 12 subjects 30 minutes before and adjust and 24 hours after the test. Results: The mean lactate concentration of 30.35±12.16 mg/dl is observed in swimmers 30 min

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3

Bakker, Jan. "Blood lactate levels." Current Opinion in Critical Care 5, no. 3 (1999): 234. http://dx.doi.org/10.1097/00075198-199906000-00013.

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4

Balakrishnan, Vamsi, John Wilson, Brent Taggart, James Cipolla, and Rebecca Jeanmonod. "Impact of Phlebotomy Tourniquet Use on Blood Lactate Levels in Acutely Ill Patients." CJEM 18, no. 5 (2016): 358–62. http://dx.doi.org/10.1017/cem.2016.6.

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AbstractObjectiveLactate levels are increasingly used to guide resuscitation efforts. Some surgical literature suggests that tourniquet use during phlebotomy falsely elevates results, although studies in healthy volunteers have not demonstrated this. The purpose of this study was to determine in clinical practice whether tourniquet use during the drawing of a lactate results in significantly altered levels compared to the result of a level drawn without a tourniquet.MethodsA prospective cohort study was carried out on emergency department patients whose clinical presentation led a physician to

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5

Buckley, J. D., P. C. Bourdon, and S. M. Woolford. "Effect of measuring blood lactate concentrations using different automated lactate analysers on blood lactate transition thresholds." Journal of Science and Medicine in Sport 6, no. 4 (2003): 408–21. http://dx.doi.org/10.1016/s1440-2440(03)80267-0.

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6

Walker, Craig A., David M. Griffith, Alasdair J. Gray, Deepankar Datta, and Alasdair W. Hay. "“Lactate Shift,” Rather Than “Lactate Clearance,” for Serial Blood Lactate Monitoring?" Critical Care Medicine 43, no. 12 (2015): e596. http://dx.doi.org/10.1097/ccm.0000000000001315.

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7

Shimojo, N., K. Fujino, S. Kitahashi, M. Nakao, K. Naka, and K. Okuda. "Lactate analyzer with continuous blood sampling for monitoring blood lactate during physical exercise." Clinical Chemistry 37, no. 11 (1991): 1978–80. http://dx.doi.org/10.1093/clinchem/37.11.1978.

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Abstract To monitor changes in the concentration of blood lactate during physical exercise, we used an automated lactate analyzer based on an electro-enzymatic method with continuous blood sampling through a catheter. The lactate concentration was measured every 2 min; between measurements, the instrument was calibrated with a lactate standard. Ascorbic acid, bilirubin, hemoglobin, creatinine, uric acid, and glucose did not interfere with the measurements. The lactate concentrations in blood samples from apparently healthy subjects before and after exercise correlated well (r = 0.993) with res

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Pyne, David B., Tanya Boston, David T. Martin, and Andrew Logan. "Evaluation of the Lactate Pro blood lactate analyser." European Journal of Applied Physiology 82, no. 1-2 (2000): 112–16. http://dx.doi.org/10.1007/s004210050659.

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9

Forrest, A. R., S. Morton, and C. Lambardarios. "Blood or plasma lactate?" British Journal of Sports Medicine 24, no. 2 (1990): 132. http://dx.doi.org/10.1136/bjsm.24.2.132.

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10

Freidheim, L. C., and G. P. Town. "BLOOD LACTATE METHODOLOGIES COMPARED." Medicine and Science in Sports and Exercise 21, Supplement (1989): S21. http://dx.doi.org/10.1249/00005768-198904001-00126.

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11

Spencer, John A. D., Sara Paterson-Brown, and Peter Brocklehurst. "Fetal blood lactate concentration." American Journal of Obstetrics and Gynecology 183, no. 5 (2000): 1308. http://dx.doi.org/10.1067/mob.2000.107464.

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12

Schierbauer, Janis, Alina Wolf, Nadine B. Wachsmuth, Norbert Maassen, and Walter F. J. Schmidt. "Relationship between Blood Volume, Blood Lactate Quantity, and Lactate Concentrations during Exercise." Metabolites 13, no. 5 (2023): 632. http://dx.doi.org/10.3390/metabo13050632.

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We wanted to determine the influence of total blood volume (BV) and blood lactate quantity on lactate concentrations during incremental exercise. Twenty-six healthy, nonsmoking, heterogeneously trained females (27.5 ± 5.9 ys) performed an incremental cardiopulmonary exercise test on a cycle ergometer during which maximum oxygen uptake (V·O2max), lactate concentrations ([La−]) and hemoglobin concentrations ([Hb]) were determined. Hemoglobin mass and blood volume (BV) were determined using an optimised carbon monoxide-rebreathing method. V·O2max and maximum power (Pmax) ranged between 32 and 62

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13

Shephard, R. J. "Evaluation of three portable blood lactate analysers: Lactate Pro, Lactate Scout and Lactate Plus." Yearbook of Sports Medicine 2011 (January 2011): 153–54. http://dx.doi.org/10.1016/s0162-0908(10)79751-8.

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14

Tanner, Rebecca K., Kate L. Fuller, and Megan L. R. Ross. "Evaluation of three portable blood lactate analysers: Lactate Pro, Lactate Scout and Lactate Plus." European Journal of Applied Physiology 109, no. 3 (2010): 551–59. http://dx.doi.org/10.1007/s00421-010-1379-9.

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15

Bazzano, Carmelo, Lee N. Cunningham, Giovanni Cama, and Tony Falconio. "The Relationship of Lactate to 1-Mile Walk Performance in Women Aged 60 to 70 Years." Journal of Aging and Physical Activity 6, no. 3 (1998): 285–89. http://dx.doi.org/10.1123/japa.6.3.285.

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The purpose of this study was to examine the relationship between selected physiological variables and lactate accumulation at the end of a l-mile walk test (MWT) in older women (mean ± SD: 64.6 ± 3.1 years). Seventeen women with a peak (ml · kg-1 · min-1) of 21.1 ± 4.2 volunteered to participate. Physiological data were obtained via a COSMED K2 miniaturized O2 analyzer with telemetric capabilities during a maximal treadmill (TM) test and MWT. Blood samples were obtained from the ear lobe for lactale analysis immediately before and after the treadmill test and MWT. Subjects performed the MWT i

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Levin, Garrett M., Jennifer J. Bonczynski, Lori L. Ludwig, Linda J. Barton, and Andrew S. Loar. "Lactate as a Diagnostic Test for Septic Peritoneal Effusions in Dogs and Cats." Journal of the American Animal Hospital Association 40, no. 5 (2004): 364–71. http://dx.doi.org/10.5326/0400364.

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Lactate concentration in peritoneal fluid was evaluated and compared to blood lactate concentration in dogs and cats with septic and nonseptic abdominal effusions. All dogs with septic effusions had a peritoneal fluid lactate concentration &gt;2.5 mmol/L and a peritoneal fluid lactate concentration higher than blood lactate, resulting in a negative blood to fluid lactate difference. In dogs, the diagnostic accuracy of the peritoneal fluid lactate concentration and the blood to fluid lactate difference in differentiating septic peritoneal effusion was 95% and 90%, respectively. Peritoneal f

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17

Ali, Mohamed, Khaled Morsy, Mai Helal, and Rasha Ahmed. "Role of blood lactate clearance in trauma patients." International Journal of Surgery and Medicine 6, no. 2 (2020): 1. http://dx.doi.org/10.5455/ijsm.blood-lactate-clearance-trauma-patients.

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18

Kost, Gerald J., Tam H. Nguyen, and Zuping Tang. "Whole-Blood Glucose and Lactate." Archives of Pathology & Laboratory Medicine 124, no. 8 (2000): 1128–34. http://dx.doi.org/10.5858/2000-124-1128-wbgal.

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Abstract Objective.—To assess the effects of 30 of the most commonly used critical care drugs on measurements obtained with trilayer electrochemical biosensors on a reference analyzer (ABL625-GL), to determine metabolic changes in glucose and lactate in vitro, and to formulate guidelines for whole-blood analysis of these 2 analytes. Design.—Serial measurements were taken of changes in glucose and lactate levels caused by metabolism in whole blood in vitro over time. A parallel control study of drug interference with measurements of glucose and lactate in whole blood and of dose-response relati

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19

Beaver, W. L., K. Wasserman, and B. J. Whipp. "Blood lactate concentration in exercise." Journal of Applied Physiology 64, no. 3 (1988): 1290–91. http://dx.doi.org/10.1152/jappl.1988.64.3.1290.

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20

Rieu, M., J. Miladi, A. Ferry, and A. Duvallet. "Blood lactate during submaximal exercises." European Journal of Applied Physiology and Occupational Physiology 59, no. 1-2 (1989): 73–79. http://dx.doi.org/10.1007/bf02396583.

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21

LaManna, Joseph C., J. Frederick Harrington, Lisa M. Vendel, Kamal Abi-Saleh, W. David Lust, and Sami I. Harik. "Regional blood-brain lactate influx." Brain Research 614, no. 1-2 (1993): 164–70. http://dx.doi.org/10.1016/0006-8993(93)91030-v.

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22

Kruse, J. A., and R. W. Carlson. "Lactate measurement: Plasma or blood?" Intensive Care Medicine 16, no. 1 (1990): 1–2. http://dx.doi.org/10.1007/bf01706317.

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23

Di Monte, Donato, James W. Tetrud, and J. William Langston. "Blood lactate in Parkinson's disease." Annals of Neurology 29, no. 3 (1991): 342–43. http://dx.doi.org/10.1002/ana.410290323.

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24

Zhang, Q., J. Puhl, and B. Jensen. "SEX DIFFERENCES IN PEAK BLOOD LACTATE CONCENTRATION AND BLOOD LACTATE REMOVAL FOLLOWING STRENUOUS EXERCISE." Medicine & Science in Sports & Exercise 24, Supplement (1992): S122. http://dx.doi.org/10.1249/00005768-199205001-00731.

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25

Mizock, B. A. "Point-of-Care Testing of Blood Lactate. Point-of-Care Testing of Blood Lactate." Laboratoriums Medizin 26, no. 1-2 (2002): 77–81. http://dx.doi.org/10.1046/j.1439-0477.2002.02029.x.

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Mizock, B. A. "Point-of-Care Testing of Blood Lactate/Point-of-Care Testing of Blood Lactate." LaboratoriumsMedizin 26, no. 1/2 (2002): 77–81. http://dx.doi.org/10.1515/labmed.2002.011.

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27

Sai Ravi Teja, Gaali, Sarath Babu Gillellamudi, and K. Suhas. "A Study on Significance of Blood Lactate Levels and Lactate Clearance in the Prognosis of Polytrauma Patients." International Journal of Science and Research (IJSR) 14, no. 4 (2025): 1370–72. https://doi.org/10.21275/mr25418095439.

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28

Brooks, George A., Adam D. Osmond, Robert G. Leija, et al. "The blood lactate/pyruvate equilibrium affair." American Journal of Physiology-Endocrinology and Metabolism 322, no. 1 (2022): E34—E43. http://dx.doi.org/10.1152/ajpendo.00270.2021.

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The Lactate Shuttle hypothesis is supported by a variety of techniques including mass spectrometry analytics following infusion of carbon-labeled isotopic tracers. However, there has been controversy over whether lactate tracers measure lactate (L) or pyruvate (P) turnover. Here, we review the analytical errors, use of inappropriate tissue and animal models, failure to consider L and P pool sizes in modeling results, inappropriate tracer and blood sampling sites, and failure to anticipate roles of heart and lung parenchyma on L⇔P interactions. With support from magnetic resonance spectroscopy

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29

Vincent, Jean-Louis. "Serial Blood Lactate Levels Reflect Both Lactate Production and Clearance." Critical Care Medicine 43, no. 6 (2015): e209. http://dx.doi.org/10.1097/ccm.0000000000000906.

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30

Barstow, T. J., W.-N. P. Lee, D. H. Cooper, and K. Wasserman. "SOURCES OF BLOOD LACTATE BELOW AND ABOVE THE LACTATE THRESHOLD." Medicine & Science in Sports & Exercise 24, Supplement (1992): S112. http://dx.doi.org/10.1249/00005768-199205001-00672.

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31

Blyth, A. M., J. Glenn, B. N. Buford, J. C. Boyce, and A. J. Koch. "RELIABILITY OF THE ARKRAY LACTATE PROTM BLOOD LACTATE TEST METER." Medicine & Science in Sports & Exercise 35, Supplement 1 (2003): S194. http://dx.doi.org/10.1097/00005768-200305001-01080.

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32

Morales, Julio Benjamin, Shannon L. Jordan, Alan D. Moore, et al. "Relationship Of Blood Lactate And Sweat Lactate To Exercise Intensity." Medicine & Science in Sports & Exercise 52, no. 7S (2020): 505. http://dx.doi.org/10.1249/01.mss.0000679636.84110.3d.

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33

Ellmerer, Martin, Martin Haluzik, Jan Blaha, et al. "Clinical Evaluation of Subcutaneous Lactate Measurement in Patients after Major Cardiac Surgery." International Journal of Endocrinology 2009 (2009): 1–8. http://dx.doi.org/10.1155/2009/390975.

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Minimally invasive techniques to access subcutaneous adipose tissue for glucose monitoring are successfully applied in type1 diabetic and critically ill patients. During critical illness, the addition of a lactate sensor might enhance prognosis and early intervention. Our objective was to evaluate SAT as a site for lactate measurement in critically ill patients. In 40 patients after major cardiac surgery, arterial blood and SAT microdialysis samples were taken in hourly intervals. Lactate concentrations from SAT were prospectively calibrated to arterial blood. Analysis was based on comparison

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34

Garin, M., L. Rossi, J. Luque, and M. Magnani. "Lactate catabolism by enzyme‐loaded red blood cells." Biotechnology and Applied Biochemistry 22, no. 3 (1995): 295–303. http://dx.doi.org/10.1111/j.1470-8744.1995.tb00352.x.

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Two different enzymes that metabolize lactate in the presence of oxygen, either to acetate plus CO2 (lactate 2‐mono‐oxygenase; Lmox) or to pyruvate plus H2O2 (lactate oxidase; Lox) were encapsulated in human and murine red blood cells (RBCs). Lmox shows a low affinity for lactate (Km 22 mM) and thus works at a low rate at the lactate concentrations found in hyperlactataemia (5‐20 mM). Encapsulation of Lox provides a constant catabolic rate under the same range of blood lactate concentrations, but generates H2O2, which is toxic to the enzyme‐loaded RBCs. Co‐encapsulation of both enzymes at a ra

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35

Czempik, Piotr F., Dawid Gierczak, Dawid Wilczek, and Łukasz J. Krzych. "The Impact of Red Blood Cell Transfusion on Blood Lactate in Non-Bleeding Critically Ill Patients—A Retrospective Cohort Study." Journal of Clinical Medicine 11, no. 4 (2022): 1037. http://dx.doi.org/10.3390/jcm11041037.

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Anemia should preferably be managed without red blood cell transfusion (RBCT); instead, therapy should be focused on causes of anemia along with efforts to minimize blood loss. Lactate could potentially be used as a physiologic RBCT trigger, although there are some limitations to its interpretation. The aim of our study was to analyze the impact of RBCT on blood lactate with consideration of factors known to increase its concentration and to assess the usefulness of blood lactate as a potential physiologic RBCT trigger. We performed a retrospective analysis of all RBCT episodes in non-bleeding

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36

Mazzeo, R. S., G. A. Brooks, G. E. Butterfield, et al. "Beta-adrenergic blockade does not prevent the lactate response to exercise after acclimatization to high altitude." Journal of Applied Physiology 76, no. 2 (1994): 610–15. http://dx.doi.org/10.1152/jappl.1994.76.2.610.

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We examined the extent to which epinephrine influences blood lactate adjustments to exercise during both acute (AC) and chronic (CH) high-altitude exposure. Eleven male sea level residents were divided into a control group (n = 5) receiving a placebo or a drug group (n = 6) receiving 240 mg/day of propranolol. All subjects were studied at rest and during 45 min of submaximal exercise (approximately 50% of sea level maximal O2 uptake) at sea level (SL) and within 4 h of exposure to and after 3 wk residence at 4,300 m (summit of Pikes Peak). Blood samples were collected from the femoral artery f

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Chen, Chiao-Nan (Joyce), Yi-Hung Liao, Shang-Ying Lin, et al. "Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 313, no. 5 (2017): R601—R607. http://dx.doi.org/10.1152/ajpregu.00337.2016.

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Blood lactate increases during incremental exercise at high-intensity workloads, and limited exercise capacity is a characteristic of obese animals. This study examined whether blood lactate changes in response to incremental exercise is disrupted in obese animals. Muscular and hepatic proteins that are critical in lactate metabolism were also investigated. Rats were randomized to either standard chow (control) or high-fat diet (HFD) groups. All animals underwent an incremental treadmill test after 14 wk of diet intervention. Blood lactate levels were measured before and after the treadmill te

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38

Pfitzinger, Peter, and Patty Freedson. "Blood Lactate Responses to Exercise in Children: Part 1. Peak Lactate Concentration." Pediatric Exercise Science 9, no. 3 (1997): 210–22. http://dx.doi.org/10.1123/pes.9.3.210.

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Part 1 reviews the literature concerning peak blood lactate responses to exercise in children. After a brief overview of lactate metabolism, an analysis is presented comparing children to adults regarding peak blood lactate concentration. Possible factors accounting for lower blood lactate concentrations during maximal exercise in children are considered.

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39

White, Rachel, Daniel Yaeger, and Stasinos Stavrianeas. "Determination of Blood Lactate Concentration: Reliability and Validity of a Lactate Oxidase-based Method." International Journal of Exercise Science 2, no. 2 (2009): 83–93. http://dx.doi.org/10.70252/rhsz6349.

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The measurement of blood lactate has long been used as marker of exercise intensity and training status. We compared a commercially available lactate oxidase spectrophotometric method (LO) to determine blood lactate levels to two previously validated methods, the lactate dehydrogenase spectrophotometric method (LDH), and the YSI 1500L Sport lactate analyzer (YSI). First we established a series of calibration curves over physiological range of lactate values (1-15 mM∙l-1 for the spectrophotometric assays and 1-30 mM∙l-1 for the YSI) with high correlations (0.986 < r < 0.999). Aerobically

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40

Cooper, Rory A., Fred D. Baldini, Michael L. Boninger, and Rosemarie Cooper. "Physiological Responses to Two Wheelchair-Racing Exercise Protocols." Neurorehabilitation and Neural Repair 15, no. 3 (2001): 191–95. http://dx.doi.org/10.1177/154596830101500306.

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Objective: This study investigated the blood lactate accumulation during two wheelchair-racing protocols. During exercise, energy is required, which causes me tabolism to increase and blood lactate to accumulate. Proper training can reduce the amount of blood lactate accumulation and increase tolerance to blood lactate accu mulation during aerobic exercise. Methods: Eleven male wheelchair elite track ath letes with a spinal cord injury were tested to determine their blood lactate response to speed and resistance workouts. A computer-monitored wheelchair dynamometer was used during all exercise

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41

Régnier, Marie-Alix, Mathieu Raux, Yannick Le Manach, et al. "Prognostic Significance of Blood Lactate and Lactate Clearance in Trauma Patients." Anesthesiology 117, no. 6 (2012): 1276–88. http://dx.doi.org/10.1097/aln.0b013e318273349d.

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Background Lactate has been shown to be a prognostic biomarker in trauma. Although lactate clearance has already been proposed as an intermediate endpoint in randomized trials, its precise role in trauma patients remains to be determined. Methods Blood lactate levels and lactate clearance (LC) were calculated at admission and 2 and 4 h later in trauma patients. The association of initial blood lactate level and lactate clearance with mortality was tested using receiver-operating characteristics curve, logistic regression using triage scores, Trauma Related Injury Severity Score as a reference

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42

Spehar-Délèze, Anna-Maria, Salzitsa Anastasova, and Pankaj Vadgama. "Monitoring of Lactate in Interstitial Fluid, Saliva and Sweat by Electrochemical Biosensor: The Uncertainties of Biological Interpretation." Chemosensors 9, no. 8 (2021): 195. http://dx.doi.org/10.3390/chemosensors9080195.

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Lactate electrochemical biosensors were fabricated using Pediococcus sp lactate oxidase (E.C. 1.1.3.2), an external polyurethane membrane laminate diffusion barrier and an internal ionomeric polymer barrier (sulphonated polyether ether sulphone polyether sulphone, SPEES PES). In a needle embodiment, a Pt wire working electrode was retained within stainless steel tubing serving as pseudoreference. The construct gave linearity to at least 25 mM lactate with 0.17 nA/mM lactate sensitivity. A low permeability inner membrane was also unexpectedly able to increase linearity. Responses were oxygen de

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Brouns, Fred, Mikael Fogelholm, Gerrit van Hall, Anton Wagenmakers, and Wim H. M. Saris. "Chronic Oral Lactate Supplementation Does Not Affect Lactate Disappearance from Blood after Exercise." International Journal of Sport Nutrition 5, no. 2 (1995): 117–24. http://dx.doi.org/10.1123/ijsn.5.2.117.

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This study tested the hypothesis that a 3-week oral lactate supplementation affects postexercise blood lactate disappearance in untrained male subjects. Fifteen men were randomly assigned to either a lactate supplementation (n = 8) or a placebo (n = 7) treatment. During the treatment period they drank an oral lactate or a maltodextrin (placebo) supplement twice a day. The lactate drink contained 10 g of lactate as calcium, sodium, and potassium salts. Blood lactate concentrations were studied before, during, and immediately after three exercise tests, both pre-and posttreatment. Peak lactate v

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44

Kovalchuk, O. O., V. A. Tomchuk, V. O. Danchuk, et al. "The intensity of carbohydrate metabolism in the body of sows under the action of ferrum and germanium nanocompounds." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 26, no. 113 (2024): 179–83. http://dx.doi.org/10.32718/nvlvet11327.

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The article shows the influence of ferrum and germanium nanoparticles on the indicators of carbohydrate metabolism in sows' blood before and after farrowing. The impact of farrowing on the content of glucose, lactate, pyruvate, and lactate dehydrogenase activity in the blood plasma of animals was established (F= 9.0–38.7 > FU = 2.9; P < 0.001). By the day of farrowing, the blood glucose content of sows increases by 14.8 % (P ≤ 0.05), lactate by 30.1 % (P ≤ 0.001), pyruvate by 15.4 % (P ≤ 0.05), lactate dehydrogenase activity by 18.0 % (P ≤ 0.05). Within ten days after farrowing, the cont

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45

Qvisth, Veronica, Eva Hagström-Toft, Staffan Enoksson та Jan Bolinder. "Catecholamine Regulation of Local Lactate Production in Vivo in Skeletal Muscle and Adipose Tissue: Role of β-Adrenoreceptor Subtypes". Journal of Clinical Endocrinology & Metabolism 93, № 1 (2008): 240–46. http://dx.doi.org/10.1210/jc.2007-1313.

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Abstract Context: The regulation of lactate production in skeletal muscle (SM) and adipose tissue (AT) is not fully elucidated. Objective: Our objective was to investigate the catecholamine-mediated regulation of lactate production and blood flow in SM and AT in healthy, normal-weight subjects by using microdialysis. Methods: First, lactate levels in SM and AT were measured during an iv norepinephrine infusion (n = 11). Local blood flow was determined with the 133Xe-clearance technique. Second, muscle lactate was measured during hypoglycemia and endogenous epinephrine stimulation (n = 12). Thi

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46

van Hall, Gerrit, Morten Stømstad, Peter Rasmussen, et al. "Blood Lactate is an Important Energy Source for the Human Brain." Journal of Cerebral Blood Flow & Metabolism 29, no. 6 (2009): 1121–29. http://dx.doi.org/10.1038/jcbfm.2009.35.

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Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 μmol per kg bw per min), and during 30mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89 ± 0.08, 3.9 ± 0.3, and 6.9 ± 1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net l

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47

Gao, Jiaping, Mohammad A. Islam, Christine M. Brennan, Beth E. Dunning, and James E. Foley. "Lactate clamp: a method to measure lactate utilization in vivo." American Journal of Physiology-Endocrinology and Metabolism 275, no. 4 (1998): E729—E733. http://dx.doi.org/10.1152/ajpendo.1998.275.4.e729.

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A lactate clamp method has been developed to quantify the whole body lactate utilization in conscious, unstressed rats. Dichloroacetate (DCA), a known lactate utilization enhancer, was used to validate the method. Fasting blood lactate concentrations before the clamps were identical for DCA-treated (1 mmol/kg) and control groups (1.65 ± 0.37 vs. 1.65 ± 0.19 mM). The animals received a primed continuous lactate infusion for 90 min at variable rates to clamp the blood lactate concentration at 2 mM. The steady-state (60–90 min) lactate infusion rate, which represents the whole body lactate utiliz

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48

von Duvillard, Serge P., Rochus Pokan, Peter Hofmann, et al. "Comparing Blood Lactate Values Of Three Different Handheld Lactate Analyzers To YSI 1500 Lactate Analyzer." Medicine & Science in Sports & Exercise 37, Supplement (2005): S25. http://dx.doi.org/10.1249/00005768-200505001-00153.

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von Duvillard, Serge P., Rochus Pokan, Peter Hofmann, et al. "Comparing Blood Lactate Values Of Three Different Handheld Lactate Analyzers To YSI 1500 Lactate Analyzer." Medicine & Science in Sports & Exercise 37, Supplement (2005): S25. http://dx.doi.org/10.1097/00005768-200505001-00153.

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van Someren, Ken A., Glyn Howatson, David Nunan, and Rhys Thatcher. "Identification of Blood Lactate Parameters Using the Lactate Pro Portable Analyzer." Medicine & Science in Sports & Exercise 36, Supplement (2004): S120—S121. http://dx.doi.org/10.1249/00005768-200405001-00573.

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