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Journal articles on the topic 'Blood lipoproteins Oxidation'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Hlozhyk, I. Z. "Biochemical Markers of Free Radical Oxidation and Lipid Exchange in Rats with Obesity, Iodine Defficiency and Obesity in Combination with Iodine Defficiency." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 4 (September 20, 2021): 166–71. http://dx.doi.org/10.26693/jmbs06.04.166.

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The purpose of the study was the content of lipid and protein peroxidation products, lipid spectrum parameters and the level of aminotransferases in obese, iodine deficient and obese rats in combination with iodine deficiency. Materials and methods. The study was performed on 45 white nonlinear rats weighing 120-180 g, which were divided into three experimental groups: obese rats (1st experimental group, n = 15), iodine-deficient animals (2nd experimental group), obese animals in combined with iodine deficiency (3rd experimental group, n = 15). The control group consisted of 15 intact rats. Th

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2

Valiyaveettil, Manojkumar, Niladri Kar, Mohammad Z. Ashraf, Tatiana V. Byzova, Maria Febbraio, and Eugene A. Podrez. "Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI." Blood 111, no. 4 (February 15, 2008): 1962–71. http://dx.doi.org/10.1182/blood-2007-08-107813.

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Numerous studies have reported the presence of oxidatively modified high-density lipoprotein (OxHDL) within the intima of atheromatous plaques as well as in plasma; however, its role in the pathogenesis of thrombotic disease is not established. We now report that OxHDL, but not native HDL, is a potent inhibitor of platelet activation and aggregation induced by physiologic agonists. This antithrombotic effect was concentration and time dependent and positively correlated with the degree of lipoprotein oxidation. Oxidized lipoproteins are known ligands for scavenger receptors type B, CD36 and sc

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Rüfer, Corinna E., Sabine E. Kulling, Jutta Möseneder, Peter Winterhalter та Achim Bub. "Role of plasma lipoproteins in the transport of the soyabean isoflavones daidzein and daidzein-7-O-β-d-glucoside". British Journal of Nutrition 102, № 6 (31 березня 2009): 793–96. http://dx.doi.org/10.1017/s0007114509297224.

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Isoflavone intake is associated with various properties beneficial to human health which are related to their antioxidant activity, for example, to their ability to increase LDL oxidation resistance. However, the distribution of isoflavones among plasma lipoproteins has not yet been elucidated in vivo. Therefore, the objective of the present study was to investigate the association between daidzein (DAI) and lipoproteins in human plasma upon administration of the aglycone and glucoside form. Five men aged 22–30 years participated in a randomised, double-blind study in cross-over design. After

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Lankin, Vadim Z., Alla K. Tikhaze, and Valeria Ya Kosach. "Comparative Susceptibility to Oxidation of Different Classes of Blood Plasma Lipoproteins." Biochemistry (Moscow) 87, no. 11 (November 2022): 1335–41. http://dx.doi.org/10.1134/s0006297922110128.

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Gorshunskaya., M. Yu. "Paraoxonase activity and lipid peroxidation in female patients with type 2 diabetes mellitus and without coronary heart disease." Problems of Endocrinology 49, no. 1 (February 15, 2003): 17–20. http://dx.doi.org/10.14341/probl11394.

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The rate of lipid peroxidation and the parameters of antioxida- tive defense, including the activity of paraoxonase that is essential for the prevention of low-density lipoprotein oxidation, was studied in 229female patients with type 2 diabetes mellitus with and without coronary heart disease (CHD) under varying glycemic control. Carbohydrate and lipid metabolisms were explored by unified biochemical studies, blood insulin levels were measured by radioimmunological assay. The activity of paraoxonase associated with high-density lipoproteins of ester hydrolase was spectrophotometrically det

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Pethő, Dávid, Tamás Gáll, Zoltán Hendrik, Annamária Nagy, Lívia Beke, Attila Péter Gergely, Gábor Méhes та ін. "Ferryl Hemoglobin and Heme Induce Α1-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation". International Journal of Molecular Sciences 22, № 13 (22 червня 2021): 6668. http://dx.doi.org/10.3390/ijms22136668.

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Infiltration of red blood cells into atheromatous plaques and oxidation of hemoglobin (Hb) and lipoproteins are implicated in the pathogenesis of atherosclerosis. α1-microglobulin (A1M) is a radical-scavenging and heme-binding protein. In this work, we examined the origin and role of A1M in human atherosclerotic lesions. Using immunohistochemistry, we observed a significant A1M immunoreactivity in atheromas and hemorrhaged plaques of carotid arteries in smooth muscle cells (SMCs) and macrophages. The most prominent expression was detected in macrophages of organized hemorrhage. To reveal a pos

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Shrestha, Rojeet, Zhen Chen, Yusuke Miura, Yusuke Yamamoto, Toshihiro Sakurai, Hitoshi Chiba, and Shu-Ping Hui. "Identification of molecular species of phosphatidylcholine hydroperoxides in native and copper-oxidized triglyceride-rich lipoproteins in humans." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 57, no. 1 (October 8, 2019): 95–98. http://dx.doi.org/10.1177/0004563219880932.

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Background Triglyceride-rich lipoproteins are considered to be independent predictors of atherosclerotic cardiovascular disease. The molecular basis of its atherogenicity is uncertain. Here, we aim to identify molecular species of phosphatidylcholine hydroperoxides (PCOOH) in triglyceride-rich lipoproteins. For comparison, copper-oxidized triglyceride-rich lipoproteins were investigated as well. Methods A fasting EDTA blood sample was collected from six healthy human volunteers to isolate two major triglyceride-rich lipoproteins fractions – very low-density lipoproteins (VLDL) and intermediate

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8

Frei, B., T. M. Forte, B. N. Ames, and C. E. Cross. "Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid." Biochemical Journal 277, no. 1 (July 1, 1991): 133–38. http://dx.doi.org/10.1042/bj2770133.

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Cigarette smoke (CS) is known to contain a large number of oxidants. In order to assess the oxidative effects of CS on biological fluids, we exposed human blood plasma to filtered (gas phase) and unfiltered (whole) CS, and determined the rate of utilization of endogenous antioxidants in relation to the appearance of lipid hydroperoxides. Lipid peroxidation was measured with a specific and sensitive assay that can detect lipid hydroperoxides at plasma levels as low as 10 nM. We found that exposure of plasma to the gas phase of CS, but not to whole CS, induces lipid peroxidation once endogenous

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9

Henein, Michael Y., Sergio Vancheri, Giovanni Longo, and Federico Vancheri. "The Role of Inflammation in Cardiovascular Disease." International Journal of Molecular Sciences 23, no. 21 (October 26, 2022): 12906. http://dx.doi.org/10.3390/ijms232112906.

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Atherosclerosis is a chronic inflammatory disease, in which the immune system has a prominent role in its development and progression. Inflammation-induced endothelial dysfunction results in an increased permeability to lipoproteins and their subendothelial accumulation, leukocyte recruitment, and platelets activation. Recruited monocytes differentiate into macrophages which develop pro- or anti-inflammatory properties according to their microenvironment. Atheroma progression or healing is determined by the balance between these functional phenotypes. Macrophages and smooth muscle cells secret

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10

Giglio, Rosaria Vincenza, Angelo Maria Patti, Arrigo F. G. Cicero, Giuseppe Lippi, Manfredi Rizzo, Peter P. Toth, and Maciej Banach. "Polyphenols: Potential Use in the Prevention and Treatment of Cardiovascular Diseases." Current Pharmaceutical Design 24, no. 2 (April 5, 2018): 239–58. http://dx.doi.org/10.2174/1381612824666180130112652.

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Background: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defence

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11

Osipenko, Alexander N. "Fatty Acid Metabolism Disorder as a Factor in Atherogenesis." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 25, no. 3 (September 1, 2018): 243–52. http://dx.doi.org/10.2478/rjdnmd-2018-0028.

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Abstract Background and aims: The study aims to analyze of fatty acid (FA) composition of arteries and blood plasma in atherosclerosis. Material and method: The blood plasma in patients with coronary atherosclerosis was studied, the blood from healthy volunteers was used as control. There were also analyzed arteries of patients with severe atherosclerotic lesions and arteries of people with significantly less atherosclerotic changes. Results: The received data indicates that there is a rather active penetration of FA from blood plasma lipoproteins into intima of arteries. Penetration of FA fro

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Potte, Juan, and Victor Hinojoza. "Protective effects of Curcumin against development of atherosclerosis." American Journal of BioMedicine 7, no. 4 (December 27, 2019): 333–41. http://dx.doi.org/10.18081/2333-5106/019-310-321.

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Atherosclerosis is characterized by oxidative damage, which affects lipoproteins, the walls of blood vessels, and subcellular membranes. The oxidation of low-density lipoproteins (LDLs) plays an important role in the development of atherosclerosis. Curcumin is a component of turmeric, a spice used in many types of cooking and gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as diferuloylmethane was determined in 1910. Since the time of Ayurveda (1900 Bc) numerous therapeutic activities have been assigned to turmeric for a wide variety of diseas

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13

Gebicki, Janusz M., Alexander V. Babiy, and David R. Sullivan. "Oxidation of blood lipoproteins by free radicals: Effects of vitamin E, glycosylation and probucol treatment." Free Radical Biology and Medicine 9 (January 1990): 69. http://dx.doi.org/10.1016/0891-5849(90)90412-c.

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14

Oostenbrug, G. S., R. P. Mensink, M. R. Hardeman, T. De Vries, F. Brouns, and G. Hornstra. "Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E." Journal of Applied Physiology 83, no. 3 (September 1, 1997): 746–52. http://dx.doi.org/10.1152/jappl.1997.83.3.746.

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Oostenbrug, G. S., R. P. Mensink, M. R. Hardeman, T. De Vries, F. Brouns, and G. Hornstra. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E. J. Appl. Physiol. 83(3): 746–752, 1997.—Previous studies have indicated that fish oil supplementation increases red blood cell (RBC) deformability, which may improve exercise performance. Exercise alone, or in combination with an increase in fatty acid unsaturation, however, may enhance lipid peroxidation. Effects of a bicycle time trial of ∼1 h on RBC characteristics and lipid peroxidation were

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Mortensen, Alicja, Birgit Fischer Hansen, Jørgen Fischer Hansen, Henrik Frandsen, Elzbieta Bartnikowska, Peder S. Andersen, and Lone S. Bertelsen. "Comparison of the effects of fish oil and olive oil on blood lipids and aortic atherosclerosis in Watanabe heritable hyperlipidaemic rabbits." British Journal of Nutrition 80, no. 6 (December 1998): 565–73. http://dx.doi.org/10.1017/s0007114598001664.

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To compare the effects of fish oil and olive oil on the development of atherosclerosis in Watanabe heritable hyperlipidaemic (WHHL) rabbits, 6-week-old animals were given a daily dose (1·5 ml/kg body weight) of fish oil (n 10) or olive oil (n 10) by oral administration for 16 weeks. Plasma cholesterol and triacylglycerols were measured once monthly, and their concentrations in lipoproteins, together with susceptibility of LDL to oxidation were measured in vitro at the termination of the experiment. Aortic atherosclerosis was quantified biochemically and microscopically. After 4 weeks of treatm

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16

Zouaoui Boudjeltia, Karim, Cédric Delporte, Pierre Van Antwerpen, Thierry Franck, Didier Serteyn, Nicole Moguilevsky, Martine Raes, et al. "Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men." Mediators of Inflammation 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/750742.

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The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL) at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process.

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17

Ermeith, Enas, Ashraf Jamal Mahmoud, and Buthaina Jassim Yousef. "The Effect of Infection by Toxocariasis on Some Biochemical Parameters in Some Areas of Salah Al-Din Governorate." Journal of Life and Bio Sciences Research 1, no. 3 (December 14, 2020): 89–92. http://dx.doi.org/10.38094/jlbsr1329.

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The current study examined 277 blood samples of people, from both sexes of different ages, living in different areas of Salah Al-Din Governorate (Tikrit, Al-Alam and Baiji districts). The study was conducted from November, 2018 to June, 2019. All participants were secrened to investigate the incidence of toxocariasis using IgG TES-ELISA technique. The results showed that the rate of infection with toxocariasis was 22%. It was found an increase in cholesterol concentrations within age group 48-58 years and amounted to 185.8 mg/dl, and highest rate of increase in triglycerides was recorded withi

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18

Lindqvist, Helen M., Anna Maria Langkilde, Ingrid Undeland, and Ann-Sofie Sandberg. "Herring (Clupea harengus) intake influences lipoproteins but not inflammatory and oxidation markers in overweight men." British Journal of Nutrition 101, no. 3 (July 18, 2008): 383–90. http://dx.doi.org/10.1017/s0007114508003073.

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Fish consumption is associated with a lower incidence of CVD and decreases in risk factors for atherosclerosis. Although fish contains other interesting components than fish oil, few studies focus on total fish composition and the influence food preparation might have on health-beneficial components. In the present cross-over intervention study the effect of a 6-week herring diet compared with a reference diet on CVD risk factors was investigated. Thirty-five healthy, but overweight, men (mean BMI 28·3 kg/m2) were randomised to a 6-week herring diet (150 g baked herring fillets/d, 5 d/week) or

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Oteiza, Ana, Ruomei Li, Robert S. McCuskey, Bård Smedsrød, and Karen Kristine Sørensen. "Effects of oxidized low-density lipoproteins on the hepatic microvasculature." American Journal of Physiology-Gastrointestinal and Liver Physiology 301, no. 4 (October 2011): G684—G693. http://dx.doi.org/10.1152/ajpgi.00347.2010.

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Oxidized low-density lipoproteins (oxLDLs) are involved in proinflammatory and cytotoxic events in different microcirculatory systems. The liver is an important scavenger organ for circulating oxLDLs. However, the interaction of oxLDL with the hepatic microcirculation has been poorly investigated. The present study was conducted to examine the effects of differently modified oxLDLs on the hepatic microvasculature. C57Bl/6J mice were injected intravenously with low-density lipoprotein (LDL), or LDL oxidized for 3 h (oxLDL3) or 24 h (oxLDL24), at doses resembling oxLDL plasma levels in cardiovas

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Kullisaar, Tiiu, Epp Songisepp, Marika Mikelsaar, Kersti Zilmer, Tiiu Vihalemm, and Mihkel Zilmer. "Antioxidative probiotic fermented goats' milk decreases oxidative stress-mediated atherogenicity in human subjects." British Journal of Nutrition 90, no. 2 (August 2003): 449–56. http://dx.doi.org/10.1079/bjn2003896.

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The increasing interest in a healthy diet is stimulating innovative development of novel scientific products in the food industry. The viable lactic acid bacteria in fermented milk products, such as yoghurt, have been associated with increased lactose tolerance, a well-balanced intestinal microflora, antimicrobial activity, stimulation of the immune system and antitumoural, anticholesterolaemic and antioxidative properties in human subjects. Recently, we have studied a humanLactobacillusspp. strain that possesses antioxidative activity. The aim of the present pilot study was to develop goats'

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Makangali, Kadyrzhan, Aigul Taeva, Andrei Lisitsyn, Yasin Uzakov, Damilya Konysbaeva, and Gorbula Victoria. "Study of the National Cooked Smoked Meat Products While Tests with Laboratory Animals at the Pathology Models with the Purpose to Confirm the set of Biocorrective Features." Current Research in Nutrition and Food Science Journal 6, no. 2 (August 25, 2018): 536–51. http://dx.doi.org/10.12944/crnfsj.6.2.28.

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Conducted physico-chemical and biological studies of Goji berries and national products made it possible to obtain information on the bioavailability of nutrients included in the product, to evaluate their food value and nutritional value, and their functional orientation. The study of the processes of digestibility and absorption of the developed products on the gastric invitro model and the monolayer of the intestinal wall epithelium showed high absorption and assimilability of the low molecular weight (from 30 kDa and below) protein fraction of the studied product. The detected acceleration

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Bozic, Tatjana, Jelka Stevanovic, Suncica Borozan, Slavoljub Jovic, Blagoje Dimitrijevic, and Igor Ignjatovic. "Influence of oxidative stress on disease development." Veterinarski glasnik 67, no. 1-2 (2013): 75–85. http://dx.doi.org/10.2298/vetgl1302075b.

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There is ever increasing data indicating the vmast contribution of oxidative stress to the pathogenesis of numerous diseases (atherosclerosis, hypertension, heart failure, diabetes mellitus, stroke, rheumatoid arthritis, and others). Thus, in the pathogenesis of atherosclerosis the primary role is held by reactive oxygen species that are synthetized by endothelial cells of arterial blood vessels, leukocytes and macrophages. Furthermore, native particles of lipoproteins of small density become atherogenic through oxidation caused by reactive oxygen species. The oxidation of small-density lipopr

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Thomas, C. E., R. L. Jackson, D. F. Ohlweiler, and G. Ku. "Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells." Journal of Lipid Research 35, no. 3 (March 1994): 417–27. http://dx.doi.org/10.1016/s0022-2275(20)41193-9.

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Micheletta, Fausta, Luigi Iuliano, and Francesco Violi. "Vitamin E, Atherosclerosis and Thrombosis." Thrombosis and Haemostasis 85, no. 05 (2001): 766–70. http://dx.doi.org/10.1055/s-0037-1615715.

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SummaryVitamin E, a major lipid-soluble, chain-breaking antioxidant includes several tocopherols having the biological activity of RRR-alpha-tocopherol. Vitamin E circulates in the blood as free tocopherol bound to beta-lipoproteins and is present in cell membrane where it exerts a potent defence against lipid peroxidation (1). Blood concentration of vitamin E in humans ranges from 25 to 30 μM, depending on daily intake and body’s ability to absorb fat (1). In the last decade the scientific interest on biological activity of vitamin E increased because of a growing body of evidence linking thi

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Sher, Elena A., Keren Hemi, Shai Efrati, Joshua Weissgarten, Matityahu Shaklai, and Nurith Shaklai. "Hemopexin Is Protective Against Intravascular Hemolysis–Induced Vascular Damage." Blood 116, no. 21 (November 19, 2010): 3207. http://dx.doi.org/10.1182/blood.v116.21.3207.3207.

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Abstract Abstract 3207 Background: Intravascular hemolysis renders hemoglobin (Hb), usually protected by the red blood cell environment, susceptible to oxidation to its ferric (metHb) form. Haptoglobin (Hp) provides first aid to protect the vasculature from acellular metHb havoc. However, once Hp is consumed, ferrous Hb readily undergoes oxidation to metHb, in which the globin to heme affinity is reduced. MetHb releases the loosely bound heme allowing it to execute its oxidative activity. While nucleated cells, like endothelial cells, are equipped with the heme oxygenase-1 defence system, the

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Ghibu, Steliana, Cristina Elena Craciun, Razvan Rusu, Claudiu Morgovan, Cristina Mogosan, Luc Rochette, Adrian Florin Gal, and Maria Dronca. "Impact of Alpha-Lipoic Acid Chronic Discontinuous Treatment in Cardiometabolic Disorders and Oxidative Stress Induced by Fructose Intake in Rats." Antioxidants 8, no. 12 (December 11, 2019): 636. http://dx.doi.org/10.3390/antiox8120636.

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Insulin resistance (IR) and cardiometabolic disorders are the main consequences of today’s alimentary behavior. This study evaluates the effects of a chronic-discontinuous treatment with alpha-lipoic acid (AL), an antioxidant substance that improves glycemic control associated with diabetes mellitus, on metabolic disorders and plasma oxidative stress induced by fructose intake, in rats. Sprague-Dawley rats (48 animals) were randomized into two series (n = 24): rats fed with standard chow or with standard chow supplemented with 60% fructose. In each of the two series, for 2 weeks/month over 12

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Dunford, H. Brian, and Yuchiong Hsuanyu. "Kinetics of oxidation of serotonin by myeloperoxidase compounds I and II." Biochemistry and Cell Biology 77, no. 5 (October 1, 1999): 449–57. http://dx.doi.org/10.1139/o99-052.

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The oxidation of serotonin (5-hydroxytryptamine) by the myeloperoxidase intermediates compounds I and II was investigated by using transient-state spectral and kinetic measurements at 25.0 ± 0.1°C. Rapid scan spectra demonstrated that both compound I and compound II oxidize serotonin via one-electron processes. Rate constants for these reactions were determined using both sequential-mixing and single-mixing stopped-flow techniques. The second order rate constant obtained for the one-electron reduction of compound I to compound II by serotonin is (1.7 ± 0.1) × 107 M-1·s-1, and that for compound

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KHAN, Jamshad, M. David BRENNAN, Nicholas BRADLEY, Beirong GAO, Richard BRUCKDORFER, and Michael JACOBS. "3-Nitrotyrosine in the proteins of human plasma determined by an ELISA method." Biochemical Journal 330, no. 2 (March 1, 1998): 795–801. http://dx.doi.org/10.1042/bj3300795.

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The modification of tyrosine residues in proteins to 3-nitrotyrosine by peroxynitrite or other potential nitrating agents has been detected in biological systems that are subject to oxidative stress. A convenient semi-quantitative method has been developed to assay nitrated proteins in biological fluids and homogenates using a competitive ELISA developed in our laboratory. This assay selectivity detected 3-nitro-L-tyrosine residues in a variety of peroxynitrite-treated proteins (BSA, human serum albumin (HSA), α1-antiprotease inhibitor, pepsinogen and fibrinogen) and also in a nitrated peptide

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Constantinescu, Alina A., Hans Vink, and Jos A. E. Spaan. "Elevated capillary tube hematocrit reflects degradation of endothelial cell glycocalyx by oxidized LDL." American Journal of Physiology-Heart and Circulatory Physiology 280, no. 3 (March 1, 2001): H1051—H1057. http://dx.doi.org/10.1152/ajpheart.2001.280.3.h1051.

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Proteoglycans and plasma proteins bound to the endothelial cell glycocalyx are essential for vascular function, but at the same time, they lower capillary tube hematocrit by reducing capillary volume available to flowing blood. Because oxidized low-density lipoproteins (oxLDL) reduce the effective thickness of the glycocalyx (Vink H, Constantinescu AA, and Spaan JAE. Circulation 101: 1500–1502, 2000), we designed the present study to determine whether this is caused by pathological degradation of glycocalyx constituents or increased glycocalyx deformation by elevated shear forces of flowing bl

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Cannon, Richard O. "Role of nitric oxide in cardiovascular disease: focus on the endothelium." Clinical Chemistry 44, no. 8 (August 1, 1998): 1809–19. http://dx.doi.org/10.1093/clinchem/44.8.1809.

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Abstract Nitric oxide is a soluble gas continuously synthesized by the endothelium. This substance has a wide range of biological properties that maintain vascular homeostasis, including modulation of vascular dilator tone, regulation of local cell growth, and protection of the vessel from injurious consequences of platelets and cells circulating in blood. A growing list of conditions, including those commonly associated as risk factors for atherosclerosis such as hypertension and hypercholesterolemia, are associated with diminished release of nitric oxide into the arterial wall either because

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Getz, Godfrey S. "An Overview of Atherosclerosis: A Look to the Future*." Toxicologic Pathology 18, no. 4a (January 1990): 623–35. http://dx.doi.org/10.1177/019262339001804a12.

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This overview briefly summarizes the cellular pathobiology of experimental atherosclerosis and is then followed by a consideration of how 3 major risk factors interact with the hypothesized pathogenetic process. First, since hemodynamics and blood flow influence the localization of atherosclerotic plaques, possible mechanisms and directions of research are considered. Secondly, the recent hypothesis relating the oxidation of LDL to several of the early processes of atherogenesis is briefly discussed in view of the fact that hyperlipidemia is a major risk factor. The possibility that subsets of

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Urquiaga, Inés, Danitza Troncoso, Maria Mackenna, Catalina Urzúa, Druso Pérez, Sara Dicenta, Paula de la Cerda, et al. "The Consumption of Beef Burgers Prepared with Wine Grape Pomace Flour Improves Fasting Glucose, Plasma Antioxidant Levels, and Oxidative Damage Markers in Humans: A Controlled Trial." Nutrients 10, no. 10 (October 1, 2018): 1388. http://dx.doi.org/10.3390/nu10101388.

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Wine grape pomace flour (WGPF) is a fruit byproduct that is high in fiber and antioxidants. We tested whether WGPF consumption could affect blood biochemical parameters, including oxidative stress biomarkers. In a three-month intervention study, 27 male volunteers, each with some components of metabolic syndrome, consumed a beef burger supplemented with 7% WGPF containing 3.5% of fiber and 1.2 mg gallic equivalents (GE)/g of polyphenols (WGPF-burger), daily, during the first month. The volunteers consumed no burgers in the second month, and one control-burger daily in the third month. At basel

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Richards, S. E., S. Hicklin, T. Lord, A. Nickson, J. Long, J. Brackenbury, and J. R. Newbold. "Effects of B vitamins and methyl group donors on milk production, milk composition and blood biochemistry in dairy cows." Proceedings of the British Society of Animal Science 2002 (2002): 196. http://dx.doi.org/10.1017/s1752756200008528.

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Recent reviews highlight the importance of the liver in the coordination of nutrient fluxes in support of pregnancy and lactation (e.g. Drackley et al., 2001). Mobilisation of body fat reserves in the late dry period and early lactation leads to an increase in uptake of non-esterified fatty acids (NEFA) by the liver. Their metabolic fate is either oxidation or esterification into triacylglycerides (TAG) that are either exported in very low density lipoproteins (VLDL) or accumulated within liver cells. Recent evidence indicates that TAG accumulation impairs ureagenic and gluconeogenic capacity

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Stancu, Camelia, Elena Constantinescu, and Anca Sima. "Ceruloplasmin and oxidized LDL colocalize in atherosclerotic lesions of hamster." Open Life Sciences 6, no. 1 (February 1, 2011): 23–31. http://dx.doi.org/10.2478/s11535-010-0076-3.

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AbstractEpidemiological studies show that the risk for cardiovascular diseases increases with increasing levels of free-copper in plasma. It is known that intact ceruloplasmin (CP), the major protein transporter of copper in human plasma, oxidizes low density lipoproteins (LDL) in vitro. Our aim was to study the interaction between LDL and CP in vitro and in vivo, in an animal model of diet-induced atherosclerosis. In order to visualize the pathway of LDL into the arterial wall, human native LDL was labeled with fluorescent DiI and injected into male, Golden Syrian hyperlipemic hamsters. In vi

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Shen, Yixiao, Jing Han, Xiaoyan Zheng, Binling Ai, Yang Yang, Dao Xiao, Lili Zheng, and Zhanwu Sheng. "Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks." Applied Sciences 10, no. 7 (March 26, 2020): 2249. http://dx.doi.org/10.3390/app10072249.

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Advanced glycation end products (AGEs) generated from glycation can cause inflammation-related diseases such as diabetes and cancer. The bioactive compounds of rosemary extract (RE) were extracted and incubated with sugar-protein rich food and breast cancer cell MCF-7 to investigate its inhibitory effect on glycation and cancer cell proliferation, respectively. The diabetic rat was dosed with RE to investigate its effect on blood glucose, serum malondialdehyde (MDA), cholesterol (CHO), triglycerides (TG), low-density lipoproteins (LDLs), anti-oxidation capacity (T-AOC), superoxide dismutase (S

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SALONEN, J. T., H. KORPELA, K. NYYSSÖNEN, E. PORKKALA, T. P. TUOMAINEN, J. D. BELCHER, D. R. JACOBS, and R. SALONEN. "Lowering of body iron stores by blood letting and oxidation resistance of serum lipoproteins: a randomized cross-over trial in male smokers." Journal of Internal Medicine 237, no. 2 (February 1995): 161–68. http://dx.doi.org/10.1111/j.1365-2796.1995.tb01156.x.

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Saptaningtyas, Ragil, Regitha Wahyuhendra, and Joko Teguh Isworo. "CORRELATION BETWEEN FASTING BLOOD SUGAR AND LDL CHOLESTEROL OF TYPE 2 DM PATIENTS ON WILLIAM BOOTH HOSPITAL SEMARANG." Jambura Journal of Health Sciences and Research 4, no. 3 (February 10, 2022): 604–8. http://dx.doi.org/10.35971/jjhsr.v4i3.12161.

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Type 2 diabetes mellitus is a metabolic disorder characterized by hyperglycemia as a result of reducing insulin secretion of pancreas beta cells or insulin function disorder. Type 2 DM can cause lipid metabolism disorder (dyslipidemia) such as increasing total cholesterol, triglyceride, and decreasing HDL levels. The small and dense , Rafparticle of LDL is susceptible to oxidation, so it makes LDL more atherogenic than other lipoproteins. A high level of LDL is a factor in atherosclerosis. It can be affected by patients’ lifestyles. The aim of this study is to figure out the relation between f

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Farinazzi-Machado, Flavia Maria Vasques. "Can the consumption of Seeds, Leaves and Fruit Peels avoid the risk factors for Cardiovascular Disorders?" International Journal of Nutrology 10, no. 02 (April 2017): 037–45. http://dx.doi.org/10.1055/s-0040-1705287.

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ABSTRACTChanges in the feeding pattern of the population have recently led to a greater occurrence of cardiovascular risk factors that contribute to a high rate of morbidity and mortality worldwide. The presence of beneficial bioactive compounds in fruits and processed sub-products have proven to have a negative association with risk factors, such as blood pressure reduction, plasmatic lipoproteins control and increased resistance of LDL-c to oxidation, in addition to glycemic control and antioxidant effects. The aim of this review is to show that several studies have demonstrated many differe

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Efimenko, Natalia V., and A. V. Abramtsova. "The specific changes in the activity of the antioxidative system of blood under the influence of courses of treatment with the use of mineral water from the Pyatigorsk source modified by nano-scale particles of selenium (an experimental study)." Russian Journal of Physiotherapy, Balneology and Rehabilitation 15, no. 3 (June 15, 2016): 116–20. http://dx.doi.org/10.18821/1681-3456-2016-15-3-116-120.

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The objective of the present study was to evaluate the influence of the courses of intake of Pyatigorsk spring water characterized by the level of mineralization up to 5.01 g / l (weakly acidic, containing sulfates, bicarbonates, chlorides, calcium, and sodium) modified by nano-scale particles of selenium. The experiments were carried out on 46 male Wistar rats allocated into 6 groups of 8 animals each (1 control group and 5 experimental groups). The animals of the former group were given native drinking mineral water during 21 days while those of the latter ones drank the same water modified

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Mason, R. Preston, Peter Libby, and Deepak L. Bhatt. "Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 5 (May 2020): 1135–47. http://dx.doi.org/10.1161/atvbaha.119.313286.

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Patients with well-controlled LDL (low-density lipoprotein) levels still have residual cardiovascular risk associated with elevated triglycerides. Epidemiological studies have shown that elevated fasting triglyceride levels associate independently with incident cardiovascular events, and abundant recent human genetic data support the causality of TGRLs (triglyceride-rich lipoproteins) in atherothrombosis. Omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower blood triglyceride concentrations but likely exert additional atheroprotective properties at hig

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Serebryakova, L. I., I. M. Studneva, O. M. Veselova, I. V. Dobrokhotov, G. G. Konovalova, A. A. Timoshin, A. A. Abramov, et al. "The anti-ischemic and antioxidant activity of the pharmacological agonist of galanin receptor GalR2 and carnosine in in vitro and in vivo model systems." Biomeditsinskaya Khimiya 68, no. 3 (2022): 190–200. http://dx.doi.org/10.18097/pbmc20226803190.

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Antioxidant and anti-ischemic properties of the pharmacological agonist of galanin receptor GalR2 WTLNSAGYLLGPβAH (Gal) and its C-terminal fragment, dipeptide carnosine (βAH), were studied in the model of regional ischemia and reperfusion of the rat heart in vivo in the dose range of 0.5-5.0 mg/kg and Cu²⁺-induced free radical oxidation of low density lipoproteins (LDL) of human plasma in vitro for peptide concentrations of 0.01 mM and 0.1 mM. Gal was obtained by automatic solid phase synthesis using the Fmoc methodology; its structure was characterized by 1H-NMR spectroscopy and MALDI-TOF mas

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Vendrame, Felipe, Leticia Marani, Sara T. Olalla Saad, Fernando F. Costa, and Kleber Yotsumoto Fertrin. "Elevated Levels of Hepatokine Angiopoietin-like 3 Correlate Paradoxically with Hypocholesterolemia and Hemolysis in Sickle Cell Anemia." Blood 132, Supplement 1 (November 29, 2018): 1069. http://dx.doi.org/10.1182/blood-2018-99-113851.

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Abstract Sickle cell disease (SCD) is characterized by chronic hemolytic anemia and vaso-occlusion. Hypocholesterolemia has been long recognized in SCD patients, and while it has been postulated that it is secondary to increased erythropoiesis, these mechanisms are not fully understood. Despite their name, angiopoietin-like proteins (ANGPTLs) are family of regulators of angiogenesis unable to bind to receptors classically targeted by angiopoetins. ANGPTL3 and ANGPTL4 are also inhibitors of lipoprotein lipase (LPL), and have become pharmacological targets in the treatment of dyslipidemia. We hy

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Varela, Lourdes M., Elena Meseguer, Bertrand Lapergue, David Couret, Pierre Amarenco, and Olivier Meilhac. "Changes in High-Density Lipoproteins Related to Outcomes in Patients with Acute Stroke." Journal of Clinical Medicine 9, no. 7 (July 17, 2020): 2269. http://dx.doi.org/10.3390/jcm9072269.

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Modifications in high-density lipoprotein (HDL) particle sizes and HDL-binding proteins have been reported in stroke patients. We evaluated whether the lipoprotein profile, HDL composition and functionality were altered in stroke patients according to their clinical outcome using the modified Rankin Score at 3 months. Plasma samples were obtained from stroke patients treated with intravenous thrombolysis. Levels of cardiovascular and inflammatory markers in plasma were measured using the Human CVD Panel 1 (Milliplex® MAP). Lipoprotein subfractions from plasma were quantified by non-denaturing

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Puga, Guilherme M., Christian Meyer, Sarah Everman, Lawrence J. Mandarino, and Christos S. Katsanos. "Postprandial lipemia in the elderly involves increased incorporation of ingested fat in plasma free fatty acids and small (Sf 20–400) triglyceride-rich lipoproteins." American Journal of Physiology-Endocrinology and Metabolism 301, no. 2 (August 2011): E356—E361. http://dx.doi.org/10.1152/ajpendo.00670.2010.

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In the elderly, the rise in postprandial plasma triglyceride (TG) concentrations is increased, contributing to their increased risk of cardiovascular disease. We sought to determine the incorporation of ingested fat (whipping cream enriched with [1,1,1-13C]triolein) into plasma lipids during the postprandial period in six healthy elderly (67 ± 1 yr old) and six healthy young (23 ± 2 yr old) subjects. Blood and expired air samples were taken before and at 2-h intervals during the 8-h postprandial period. As expected, the area under the curve of postprandial plasma TG concentrations was larger i

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Lamuela-Raventós, R. M., A. I. Romero-Pérez, C. Andrés-Lacueva, and A. Tornero. "Review: Health Effects of Cocoa Flavonoids." Food Science and Technology International 11, no. 3 (June 2005): 159–76. http://dx.doi.org/10.1177/1082013205054498.

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Flavonoids are phenolic substances widely found in fruits and vegetables. Many epidemiological studies associate the ingestion of flavonoids with a reduced risk of cardiovascular disease and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins (LDL) oxidation and platelet aggregation, acting as vasodilators in blood vessels, inhibiting the adherence of monocytes to the vascular endothelium, promoting fibrinolysis, acting as immunomodulators and anti-inflammatory agents and as inhibit

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Gross, Myron, Michael Steffes, David R. Jacobs, Xinhua Yu, Linda Lewis, Cora E. Lewis, and Catherine M. Loria. "Plasma F2-Isoprostanes and Coronary Artery Calcification: The CARDIA Study." Clinical Chemistry 51, no. 1 (January 1, 2005): 125–31. http://dx.doi.org/10.1373/clinchem.2004.037630.

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Abstract Background: Oxidation of lipids in lipoproteins and cells may initiate and enhance the early development of cardiovascular disease. Method and Results: We assayed F2-isoprostanes, oxidation products of arachidonic acid, by gas chromatography–mass spectrometry in a biracial cohort of 2850 young healthy adult men and women. Coronary artery calcification (CAC), a component of coronary artery atherosclerosis, was detectable in 10% of the cohort and appeared to be in its initial stages (Agatston scores &lt;20 in 47% and &lt;100 in 83% of CAC-positive participants). After adjusting

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Jandrić-Kočić, Marijana. "The importance of polyphenols in the prevention of chronic non-communicable diseases." Zdravstvena zastita 50, no. 3 (2021): 91–106. http://dx.doi.org/10.5937/zdravzast50-33638.

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Polyphenols are compounds that contain in their structure one or more hydroxyl groups attached directly to one or more aromatic hydrocarbons. They represent one of the most numerous and widespread groups of secondary plant metabolites with more than 8000 polyphenolic structures. Polyphenols are antioxidants that reduce endothelial dysfunction and blood pressure, improve the immune defense, alleviate the inflammatory response, block platelet aggregation and oxidation of low-density lipoproteins. Some studies suggest that there is an indirect link between flavonoid intake and myocardial infarcti

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Holvoet, Paul, Jan Donck, Michèle Landeloos, Els Brouwers, Kristel Luijtens, Jozef Arnout, Emmanuel Lesaffre, Yves Vanrenterghem, and Désiré Collen. "Correlation between Oxidized Low Density Lipoproteins and von Willebrand Factor in Chronic Renal Failure." Thrombosis and Haemostasis 76, no. 05 (1996): 663–69. http://dx.doi.org/10.1055/s-0038-1650639.

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SummaryAn ELISA specific for a wide spectrum of oxidized apo B-100 in OxLDL was developed and applied to blood samples from 27 control subjects, 20 mild chronic renal failure (MCRF) patients, 21 severe chronic renal failure patients on conservative treatment (SCRF) and 56 severe chronic renal failure patients on maintenance hemodialysis (HEMO). Mean levels of OxLDL were 0.59 mg/dl in controls (95% Cl, 0.52-0.66 mg/dl), and were 2.7-fold (p <0.01), 3.1-fold (p <0.001) and 5.4-fold (p <0.001) higher in MCRF, SCRF and HEMO patients, respectively. Levels of von Willebrand factor, a marker

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Farinazzi-Machado, Flavia Maria Vasques. "Can the consumption of Seeds, Leaves and Fruit Peels avoid the risk factors for Cardiovascular Disorders?" International Journal of Nutrology 10, no. 2 (April 12, 2017): 37. http://dx.doi.org/10.22565/ijn.v10i2.270.

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Changes in the feeding pattern of the population have recently led to a greater occurrence of<br />cardiovascular risk factors that contribute to a high rate of morbidity and mortality worldwide. The<br />presence of beneficial bioactive compounds in fruits and processed sub-products have proven to have<br />a negative association with risk factors, such as blood pressure reduction, plasmatic lipoproteins control<br />and increased resistance of LDL-c to oxidation, in addition to glycemic control and antioxidant effects.<br />The aim of this review is to show that

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Vendrame, Felipe, Sara T. O. Saad, Fernando F. Costa, and Kleber Yotsumoto Fertrin. "Circulating Lipoprotein Concentrations Correlate with Total but Not Free Heme in Different Sickle Cell Disease Genotypes." Blood 126, no. 23 (December 3, 2015): 4580. http://dx.doi.org/10.1182/blood.v126.23.4580.4580.

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Abstract In chronic hemolytic states, hemoglobin is released in the bloodstream and free heme is formed upon hemoglobin oxidation. Free heme has been shown to trigger vaso-occlusion in animal models of sickle cell disease (SCD) by activating endothelial cells through toll-like receptor 4 (TLR4). Serum levels of glycoproteins specialized in clearing hemoglobin and heme, such as haptoglobin and hemopexin, are typically depleted in SCD plasma. High-density (HDL) and low-density lipoproteins (LDL) can also bind heme and work as the first line of defense against heme toxicity. Heme can react with L

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