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Journal articles on the topic 'Blood lymphocytes'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Spain, B. A., D. M. Soliman, R. A. Sidner, and H. L. Twigg. "Enhanced proliferation and IL-2 secretion by lung lymphocytes from HIV-infected subjects." American Journal of Physiology-Lung Cellular and Molecular Physiology 269, no. 4 (1995): L498—L506. http://dx.doi.org/10.1152/ajplung.1995.269.4.l498.

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Human immunodeficiency virus (HIV)-positive patients frequently develop a CD3+/CD8+ cytotoxic T cell lymphocytic alveolitis. This could occur through in situ expansion of lung lymphocytes. We evaluated lung and blood lymphocyte proliferation in asymptomatic HIV-infected individuals by measuring spontaneous and cytokine-induced tritiated thymidine incorporation. Interleukin (IL)-2 and IL-4 secretion was determined with the use of enzyme-linked immunosorbent assay, Western blotting, and immunoprecipitation techniques. Spontaneous proliferation by lung lymphocytes from HIV-positive patients was s

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Winther, Birgit, Donald J. Innes, John Bratsch, and Frederick G. Hayden. "Lymphocyte Subsets in the Nasal Mucosa and Peripheral Blood during Experimental Rhinovirus Infection." American Journal of Rhinology 6, no. 4 (1992): 149–56. http://dx.doi.org/10.2500/105065892781874621.

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The local cellular response during rhinovirus infection was studied with immunohistochemical staining of lymphocyte subpopulations in the lamina propria of the nasal mucosa (inferior turbinate) in 25 biopsies from volunteers with experimental rhinovirus colds and compared with biopsies from healthy volunteers. Biopsies from rhinovirus infected volunteers, taken either in the early phase of the infection (days 3 and 5) or during convalescence (day 14) were evaluated in a semiquantitative fashion for degree of infiltration. Lymphocyte subpopulations also were counted on coded specimens. During e

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3

Lucivero, G., G. Pierucci, and L. Bonomo. "Lymphocyte subsets in peripheral blood and pleural fluid." European Respiratory Journal 1, no. 4 (1988): 337–40. http://dx.doi.org/10.1183/09031936.93.01040337.

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We have examined the distribution of B and T lymphocytes, T-cells with helper/inducer (T4+) or suppressor/cytotoxic (T8+) phenotypes and a subset of cells with natural killer (NK) activity and positive for the Leu 7 (HNK-1) surface antigen in peripheral blood and in lymphocyte-rich pleural effusions of patients with tuberculosis or malignancies (mesothelioma and lung cancer with pleural metastasis). In individual patients, the percentages of T lymphocytes were uniformly higher in pleural effusions than in peripheral blood; however, lower percentages of B lymphocytes and cells positive for the

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Klein, Ami, Michael Lishner, Barbara Bruser, John E. Curtis, Dominick J. Amato, and Aaron Malkin. "Cortisol catabolism by lymphocytes of patients with chronic lymphocytic leukemia." Biochemistry and Cell Biology 68, no. 4 (1990): 810–13. http://dx.doi.org/10.1139/o90-118.

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A low rate of catabolism of cortisol by lymphocytes correlates with high sensitivity of the cells to the steroid and causes them to die at a greater rate than control samples. Since lymphocytes of patients with chronic lymphocytic leukemia respond to treatment with glucocorticosteroids and are cortisol sensitive, we attempted to see whether their capability to catabolize cortisol differs from that of normal lymphocytes. No difference was found between the two groups of cells with regard to the pattern of cortisol metabolites. However, the lymphocytes of the chronic lymphocytic leukemia groups

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5

Andrade, William N., Miles G. Johnston, and John B. Hay. "The Relationship of Blood Lymphocytes to the Recirculating Lymphocyte Pool." Blood 91, no. 5 (1998): 1653–61. http://dx.doi.org/10.1182/blood.v91.5.1653.

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Abstract Lymphocyte recirculation facilitates the detection and elimination of pathogens and the dissemination of immunologic memory. It is generally assumed that all small lymphocytes in the blood are actively recirculating, yet there is little quantitative data directly comparing the migration of this population with actively recirculating, lymph-derived lymphocytes. In this study blood lymphocytes were labeled with fluorescein isothiocyanate (FITC), and lymph lymphocytes were labeled with CM-DiI, reinfused intravenously, and monitored in blood and lymph. After equilibration the concentratio

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6

Andrade, William N., Miles G. Johnston, and John B. Hay. "The Relationship of Blood Lymphocytes to the Recirculating Lymphocyte Pool." Blood 91, no. 5 (1998): 1653–61. http://dx.doi.org/10.1182/blood.v91.5.1653.1653_1653_1661.

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Lymphocyte recirculation facilitates the detection and elimination of pathogens and the dissemination of immunologic memory. It is generally assumed that all small lymphocytes in the blood are actively recirculating, yet there is little quantitative data directly comparing the migration of this population with actively recirculating, lymph-derived lymphocytes. In this study blood lymphocytes were labeled with fluorescein isothiocyanate (FITC), and lymph lymphocytes were labeled with CM-DiI, reinfused intravenously, and monitored in blood and lymph. After equilibration the concentration of bloo

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7

Hay, John B., and William N. Andrade. "Lymphocyte recirculation, exercise, and immune responses." Canadian Journal of Physiology and Pharmacology 76, no. 5 (1998): 490–96. http://dx.doi.org/10.1139/y98-051.

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Alterations in leukocyte concentrations in the blood are associated with exercise, stress, and other pathophysiological perturbations. The continuous migration and redistribution of cells of the recirculating lymphocyte pool between the blood and lymphatic systems can be influenced by a variety of physiological, immunological, and pathological processes. The phenotypic distribution of lymphocyte subsets is not the same in blood, afferent lymph, and efferent lymph, and cell-tracking experiments have shown that lymphocytes vary in their migratory properties. The most comprehensive physiological

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8

Choccalingam, Chidambharam. "Volume, conductance, and scatter parameters of neoplastic and nonneoplastic lymphocytes using Coulter LH780." Journal of Laboratory Physicians 10, no. 01 (2018): 085–88. http://dx.doi.org/10.4103/jlp.jlp_65_17.

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Abstract PURPOSE: Automated hematology analyzers yield a complete hematological profile including a complete blood count and a differential white blood cell count. The differential count is based on analyses of three parameters, namely, volume, conductance, and scatter (VCS). We aimed to evaluate the VCS parameters, histograms, and scatterplots of neoplastic and nonneoplastic lymphocytes. MATERIAL AND METHODS: Patients were grouped into four categories, namely, acute lymphoblastic leukemia (ALL), chronic systemic disorders, chronic lymphocytic leukemia (CLL), and acute viral disease. Lymphocyt

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9

Mirkamali, Mona, Hamid Reza Momeni, Tahereh Etemadi, Ghasem Mosayebi, and Majid Komijani. "Involvement of caspase-3 in apoptosis of human lymphocytes exposed to cadmium chloride." Human & Experimental Toxicology 41 (January 2022): 096032712211217. http://dx.doi.org/10.1177/09603271221121796.

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Background Lymphocytes are a group of white blood cells with a variety of roles their integrity is crucial for the body’s immune responses. Cadmium, a heavy metal and environmental pollutant, is known as a toxicant to exert its adverse effects on some sort of cells including blood cells. Research Design In this study, human lymphocytes were divided into 3 groups: (1) lymphocytes at 0-h, (2) lymphocytes at 24 h (control), (3) lymphocytes treated with cadmium chloride (15 μM). Lymphocyte viability and plasma membrane integrity were assessed in these groups. In addition, the occurrence of apoptos

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10

Twigg, Homer L., Blake A. Spain, Diaa M. Soliman та ін. "Production of interferon-γ by lung lymphocytes in HIV-infected individuals". American Journal of Physiology-Lung Cellular and Molecular Physiology 276, № 2 (1999): L256—L262. http://dx.doi.org/10.1152/ajplung.1999.276.2.l256.

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A CD8+lymphocytic alveolitis occurs in up to 60% of asymptomatic human immunodeficiency virus (HIV)-infected individuals. Early in HIV infection, lymphocytes consist predominantly of cytotoxic T lymphocytes directed against HIV-infected targets. As HIV disease progresses, they are replaced by CD8+CD57+suppressor cells. Virus-specific cytotoxic T lymphocytes secrete interferon-γ (IFN-γ), an important cytokine in upregulating immune responses, primarily through macrophage activation. We examined the ability of lung and blood lymphocytes from HIV-positive patients at various stages of HIV infecti

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11

Komal, Dhakane* Randhawan B. B. Harish Changediya Pruthviraj Awate Naman Gandhi. "Key Treatment, Principles, and Recent Updates in the Management of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 453–62. https://doi.org/10.5281/zenodo.14274926.

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Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a common indolent B-cell malignancy characterized by the accumulation of mature B lymphocytes in the blood, bone marrow, and lymphoid tissues. The management of CLL/SLL has evolved significantly in recent years, with advances in targeted therapies and novel immunotherapies. Chronic lymphocytic leukemia (CLL) is a type of cancer that affects white blood cells called lymphocytes. Lymphocytes are part of the immune system and help fight infections. In Chronic Lymphocytic Leukemia, the lymphocytes grow and accumulate abnormally

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12

Vera, Juan, Barbara Savoldo, Stephane Vigouroux та ін. "T lymphocytes redirected against the κ light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells". Blood 108, № 12 (2006): 3890–97. http://dx.doi.org/10.1182/blood-2006-04-017061.

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AbstractThere has been interest in generating T cells expressing chimeric artificial receptors (CARs) targeting CD19/CD20 antigens to treat B-cell lymphomas. If successful, however, this approach would likely impair humoral immunity because T cells may persist long-term. Most low-grade lymphoma and chronic lymphocytic leukemia (B-CLL) cells express monoclonal immunoglobulins carrying either κ or λ light chains. We, therefore, explored whether T lymphocytes could be genetically modified to target the tumor-associated light chain, sparing B lymphocytes expressing the reciprocal light chain, and

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13

Seabrook, Tim J., Wayne R. Hein, Lisbeth Dudler, and Alan J. Young. "Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool." Blood 96, no. 3 (2000): 1180–83. http://dx.doi.org/10.1182/blood.v96.3.1180.

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Abstract The spleen plays a major role in immune surveillance, but the impact that splenectomy exerts on the immune competence of an individual is not fully resolved. Here we show that neonatal splenectomy in sheep does not abrogate the development of a large, nonrecirculating pool of lymphocytes and that it has no effect on the acquisition of a normal blood lymphocyte profile. Splenectomy did, however, result in a significant decrease in blood residency time of recirculating lymphocytes and in an enhanced accumulation of recirculating lymphocytes in lymph nodes. Furthermore, nonrecirculating

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Seabrook, Tim J., Wayne R. Hein, Lisbeth Dudler, and Alan J. Young. "Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool." Blood 96, no. 3 (2000): 1180–83. http://dx.doi.org/10.1182/blood.v96.3.1180.015k24_1180_1183.

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The spleen plays a major role in immune surveillance, but the impact that splenectomy exerts on the immune competence of an individual is not fully resolved. Here we show that neonatal splenectomy in sheep does not abrogate the development of a large, nonrecirculating pool of lymphocytes and that it has no effect on the acquisition of a normal blood lymphocyte profile. Splenectomy did, however, result in a significant decrease in blood residency time of recirculating lymphocytes and in an enhanced accumulation of recirculating lymphocytes in lymph nodes. Furthermore, nonrecirculating periphera

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15

de Armas-Rillo, Sergio, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández, and Fernando Lahoz. "Analysis of Random Lasing in Human Blood." Biosensors 14, no. 9 (2024): 441. http://dx.doi.org/10.3390/bios14090441.

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Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye solutions with different blood components, including platelets, lymphocytes, erythrocytes, and whole blood. Intense coherent RL was obtained in all cases at relatively low pump thresholds, except for erythrocytes. We also studied the potential of RL signal analysis for biosensing applications using blood samples fr

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16

Concha, Carlos, and Olof Holmbebg. "Ability of bovine mammary macrophages to enhance proliferation of autologous blood and mammary secretion lymphocytes." Journal of Dairy Research 57, no. 1 (1990): 7–16. http://dx.doi.org/10.1017/s0022029900026558.

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SummaryCells were obtained by centrifuging the mammary secretion of healthy udders of 19 cows during the dry-period and during mid-lactation. The suspended cells were incubated in plastic wells. Those adhered cells classified as mammary macrophages were incubated with pokeweed mitogen (PWM). Autologous peripheral blood lymphocytes were added to wells containing untreated macrophage cultures or cultures pretreated with PWM. In seven cows autologous dry-period mammary lymphocytes were added instead of blood lymphocytes. The macrophages + lymphocyte cultures were subjected to the lymphocyte stimu

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17

Rajakariar, Ravindra, Toby Lawrence, Jonas Bystrom, et al. "Novel biphasic role for lymphocytes revealed during resolving inflammation." Blood 111, no. 8 (2008): 4184–92. http://dx.doi.org/10.1182/blood-2007-08-108936.

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Abstract Acute inflammation is traditionally described as the influx of polymorphonuclear leukocytes (PMNs) followed by monocyte-derived macrophages, leading to resolution. This is a classic view, and despite subpopulations of lymphocytes possessing innate immune-regulatory properties, seldom is their role in acute inflammation and its resolution discussed. To redress this we show, using lymphocyte-deficient RAG1−/− mice, that peritoneal T/B lymphocytes control PMN trafficking by regulating cytokine synthesis. Once inflammation ensues in normal mice, lymphocytes disappear in response to DP1 re

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18

Majstoravich, Sonja, Jinyi Zhang, Susan Nicholson-Dykstra, et al. "Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology." Blood 104, no. 5 (2004): 1396–403. http://dx.doi.org/10.1182/blood-2004-02-0437.

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Abstract Short microvilli cover the surfaces of circulating mammalian lymphocytes. The surfaces of monocytes and neutrophils are very different, containing ruffles as their predominant structure. In this study, we present the first quantitative characterization of lymphocyte microvilli. From analysis of scanning electron micrographs, we find that median microvillar length and surface density range from 0.3 to 0.4 μm and 2 to 4 microvilli/μm2, respectively, on lymphocytes from a variety of sources. As with similar structures from other cells, lymphocyte microvilli contain parallel bundles of ac

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19

Nimmanapalli, Ramadevi, Mi-Ae Lyu, Min Du, Michael J. Keating, Michael G. Rosenblum, and Varsha Gandhi. "The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R–positive CLL cells." Blood 109, no. 6 (2006): 2557–64. http://dx.doi.org/10.1182/blood-2006-08-042424.

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Abstract The cytokine B lymphocyte stimulator (BLyS) mediates its effect through cell-surface receptors BAFF-R, TACI, and BCMA. BLyS receptors are expressed only on B cells and not present in other normal cells including normal T lymphocytes. Chronic lymphocytic leukemia (CLL) is a B-cell disease and CLL lymphocytes express BLyS receptors. Gelonin, a type 1 ribosome-inactivating toxin, lacks cell membrane binding domain and hence is nontoxic to intact cells. We generated a construct of recombinant gelonin (rGel) fused to BLyS to specifically target quiescent B-CLL lymphocytes. The construct rG

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20

Parkman, Robertson, Geoff Cohen, Shelley L. Carter, et al. "Antigen-Specific T Lymphocyte Function Following Unrelated Cord Blood Transplantation (UCBT)." Blood 106, no. 11 (2005): 3032. http://dx.doi.org/10.1182/blood.v106.11.3032.3032.

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Abstract The T lymphocytes contained in cord blood are naïve and do not have antigen-specific function. Since the antigen-specific T lymphocytes contained in other hematopoietic stem cell (HSC) source may contribute to protective cellular immunity following transplantation, it has been hypothesized that the recipients of cord blood transplantation (CBT) might be at increased risk of opportunistic infections. The development of antigen-specific T lymphocyte function was measured in 153 recipients of unrelated cord blood transplants (UCBT) by determining antigen-specific T lymphocyte proliferat

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Maslak, G. S., G. P. Chernenko, S. V. Abramov, et al. "Glycobiom Lymphocytes Surface Study of Patients with B-Cell Chronic Lymphocytic Leukemia." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 6 (2021): 134–40. http://dx.doi.org/10.26693/jmbs06.06.134.

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The purpose of the study was to investigate the intensity of exposure of peripheral blood lymphocyte surface glycans in patients with B-cell chronic lymphocytic leukemia by measuring the density of lectin- or antigen-positive epitopes under antitumor therapy in order to evaluate it for a more reasonable selection of qualitative and quantitative composition of therapy. Materials and methods. The objects of the study were blood lymphocytes of patients with chronic lymphocytic leukemia (n=15) aged 58-66 years before and after a course of standard chemotherapy according to the COP scheme. The cont

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Westermann, J., S. Persin, J. Matyas, P. van der Meide, and R. Pabst. "IFN-gamma influences the migration of thoracic duct B and T lymphocyte subsets in vivo. Random increase in disappearance from the blood and differential decrease in reappearance in the lymph." Journal of Immunology 150, no. 9 (1993): 3843–52. http://dx.doi.org/10.4049/jimmunol.150.9.3843.

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Abstract Thoracic duct lymphocytes (TDL) continuously patrol through the body, facilitating immune responses at most sites. IFN-gamma might regulate immune responses by influencing the migration of TDL. Therefore, it was investigated in vivo whether IFN-gamma affects the migration of thoracic duct B, T, CD4+, and CD8+ lymphocytes from blood to lymph. Labeled TDL were injected i.v. into rats continuously receiving IFN-gamma via a central venous catheter. The numbers of B, T, CD4+, and CD8+ lymphocytes were determined in blood and thoracic duct lymph for 120 h. IFN-gamma increased the disappeara

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Elsken, Lawrence A., and Brian J. Nonnecke. "In vitro transformation of lymphocytes from blood and milk of cows with subclinical paratuberculosis." American Journal of Veterinary Research 47, no. 7 (1986): 1513–16. https://doi.org/10.2460/ajvr.1986.47.07.1513.

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SUMMARY Lymphocytes from blood or milk of 12 cows were evaluated in vitro for the lymphocyte's capability to proliferate in response to mitogens (phytohemagglutinin-A, concanavalin A, and pokeweed mitogen) and to an antigen prepared from Mycobacterium paratuberculosis (purified protein derivative, ppd-j). Responses of 4 control cows were compared with those of 4 cows subclinically infected with M paratuberculosis and with 4 apparently noninfected herdmates. Blood lymphocytes or milk lymphocytes from control cows had no detectable responses to ppd-j. Blood lymphocytes from infected cows had sig

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Maslak, G. S., G. P. Chernenko, V. M. Baibakov, et al. "Changes in Glycanic Determinants of Lymphocytes Membranes in Peripheral Blood in Patients with B-Cell Chronic Lymphocytic Leukemia under Antitumor Therapy." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 6 (2021): 141–47. http://dx.doi.org/10.26693/jmbs06.06.141.

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The purpose of the study was to study the nature of changes in the exposure of surface glycans of peripheral blood lymphocytes in patients with B-cell chronic lymphocytic leukemia under conditions of antitumor therapy. Materials and methods. We studied the features of exposure of surface glycotopes of peripheral blood lymphocytes in patients with B-cell chronic lymphocytic leukemia under conditions of antitumor therapy using a set of seven lectins labeled with FITC and monoclonal antibodies to Tn-antigen- FITC for the detection of Tn antigen and CD43 exposure on blood lymphocytes. Cytostatic t

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Schimpff, R. M., and A. M. Repellin. "In vitro effect of human growth hormone on lymphocyte transformation and lymphocyte growth factors secretion." Acta Endocrinologica 120, no. 6 (1989): 745–52. http://dx.doi.org/10.1530/acta.0.1200745.

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Abstract. Cultures of human blood peripheral lymphocytes were performed in the presence or absence of human growth hormone, and also of phytohemagglutinin and normal human serum 10%. After incubation for 48 h, the supernatants were tested for their ability to promote the uptake of [3H]thymidine into lectin-activated lymphocytes. Supernatants from lymphocyte-free control samples, treated in the same manner, were assayed under the same experimental conditions. Variance analysis of the different dose-response relationships was performed. The results of these in vitro experiments confirm that phys

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Ryu, Hoon, Chang Duk Jun, Bok Soo Lee, Byung Min Choi, Hyung Min Kim, and Hun-Taeg Chung. "Effect of Qigong Training on Proportions of T Lymphocyte Subsets in Human Peripheral Blood." American Journal of Chinese Medicine 23, no. 01 (1995): 27–36. http://dx.doi.org/10.1142/s0192415x95000055.

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The effect of Qigong training on proportions of T lymphocyte subsets was investigated in human peripheral blood. We observed that the ratio of CD4+/CD8+ T lymphocytes was increased as much as 50% in a trainee group who practiced Qigong training more than 5 months compared to a normal healthy group who did not practice. The absolute number of CD4+ T lymphocytes was also elevated in trainee group with 100 cells/mm 3 more than in normal healthy group. The positive correlation between the ratio of CD4+/CD8+ T lymphocytes and the ratio of CD4+45RA-/CD4+ CD45RA+ T lymphocytes was shown in the traine

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Williams, Diana L., Grace F. Amborski, and William C. Davis. "Enumeration of T and B lymphocytes in bovine leukemia virus-infected cattle, using monoclonal antibodies." American Journal of Veterinary Research 49, no. 7 (1988): 1098–103. https://doi.org/10.2460/ajvr.1988.49.07.1098.

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SUMMARY Monoclonal antibodies and microfluorimetry were used to determine the absolute number of B and T lymphocytes in the blood of bovine leukemia virus (blv)-infected cows. The blood lymphocyte populations from blv-infected cows were significantly higher than those from blv-negative cows. The increase in the lymphocyte population in 3 blv-infected nonlymphocytotic cows was attributed to a significant increase in the number of T lymphocytes; in 3 blv-infected persistently lymphocytotic cows, the increase was attributed to a significant increase in the number of B and T lymphocytes. One persi

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Ganusov, Vitaly. "Rapid migration of lymphocytes via murine spleen (CAM1P.226)." Journal of Immunology 192, no. 1_Supplement (2014): 47.2. http://dx.doi.org/10.4049/jimmunol.192.supp.47.2.

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Abstract Spleen is the major secondary lymphoid organ in mammals playing an important role in initiation of adaptive immune response to blood-borne pathogens. Yet, the kinetics of lymphocyte recirculation via spleen in resting and inflammatory conditions remain poorly defined. By perfusing blood and lymphocytes via murine spleen in vitro Ford (Cell Tissue Kinetics 1969) measured accumulation of lymphocytes in circulation over the time of perfusion. I developed a novel mathematical model of lymphocytes recirculation via spleen and fitted that model to Ford's experimental data. The model explain

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Seemen Ghafoor, Azra Saleem, Abdullah Abbasi, and Shaheena. "Levels of Fructose-2,6-Bisphosphate in Lymphocytes of Diabetic Patients." JMMC 4, no. 1 (2013): 24–26. http://dx.doi.org/10.62118/jmmc.v4i1.337.

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Background: Patients with diabetes mellitus have infections more often than those without diabetes. Severalfactors predispose diabetic patients to infections, including an alteration in immune defense mechanism. Elevated levels of fructose-2,6- bisphosphate in lymphocyte have been shown in diabetic patients. The activation ofglycolysis by fructose -2,6- bisphosphate in peripheral blood mononuclear cells causes the accumulation of glycolytic metabolites and inhibits the activation of immune cells.Objective: To observe and compare the levels of fructose-2,6-bisphosphate in lymphocytes of diabeti

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Kenney, D., L. Cairns, E. Remold-O'Donnell, J. Peterson, FS Rosen, and R. Parkman. "Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome." Blood 68, no. 6 (1986): 1329–32. http://dx.doi.org/10.1182/blood.v68.6.1329.1329.

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Abstract Lymphocytes from 18 patients with the Wiskott-Aldrich Syndrome (WAS) were examined by scanning electron microscopy (SEM). Most peripheral blood lymphocytes from normal individuals are covered with slender microvillus projections, but a large proportion of lymphocytes from WAS patients were found to be relatively devoid of microvilli. A lymphocyte morphology scoring system was developed to quantify the density of microvilli: Grade 4 classified those lymphocytes with greater than 75% of the surface covered with microvilli with progressive decrements to grade 1, which were those without

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Kenney, D., L. Cairns, E. Remold-O'Donnell, J. Peterson, FS Rosen, and R. Parkman. "Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome." Blood 68, no. 6 (1986): 1329–32. http://dx.doi.org/10.1182/blood.v68.6.1329.bloodjournal6861329.

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Lymphocytes from 18 patients with the Wiskott-Aldrich Syndrome (WAS) were examined by scanning electron microscopy (SEM). Most peripheral blood lymphocytes from normal individuals are covered with slender microvillus projections, but a large proportion of lymphocytes from WAS patients were found to be relatively devoid of microvilli. A lymphocyte morphology scoring system was developed to quantify the density of microvilli: Grade 4 classified those lymphocytes with greater than 75% of the surface covered with microvilli with progressive decrements to grade 1, which were those without microvill

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Janker, Stefanie, Simon Doswald, Roman R. Schimmer, et al. "Targeted Large-Volume Lymphocyte Removal Using Magnetic Nanoparticles in Blood Samples of Patients with Chronic Lymphocytic Leukemia: A Proof-of-Concept Study." International Journal of Molecular Sciences 24, no. 8 (2023): 7523. http://dx.doi.org/10.3390/ijms24087523.

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In the past, our research group was able to successfully remove circulating tumor cells with magnetic nanoparticles. While these cancer cells are typically present in low numbers, we hypothesized that magnetic nanoparticles, besides catching single cells, are also capable of eliminating a large number of tumor cells from the blood ex vivo. This approach was tested in a small pilot study in blood samples of patients suffering from chronic lymphocytic leukemia (CLL), a mature B-cell neoplasm. Cluster of differentiation (CD) 52 is a ubiquitously expressed surface antigen on mature lymphocytes. Al

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Kodintseva, E. A., and A. А. Akleyev. "Prospects and Methods for Studying the Proliferative Capacity of the Human Peripheral Blood Lymphocyte Subpopulations in Radiation Medicine." MEDICAL RADIOLOGY AND RADIATION SAFETY 69, no. 5 (2024): 66–74. http://dx.doi.org/10.33266/1024-6177-2024-69-5-66-74.

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Introduction 1. Proliferation of peripheral blood lymphocytes as an integrative indicator of the functional activity of ICS in normal and pathological conditions. 2. Features of proliferative activity of peripheral blood lymphocytes under the action of AI. 3. Methodological approaches to the quantitative determination of proliferating cells in human peripheral blood lymphocyte subpopulations. Conclusion

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Soloviev, V. Yu, and E. A. Gudkov. "Application of Hematological Test Results for Severity Assessment of Acute Radiation Injury on Early Stages." MEDICAL RADIOLOGY AND RADIATION SAFETY 67, no. 3 (2022): 26–29. http://dx.doi.org/10.33266/1024-6177-2022-67-3-26-29.

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Purpose: Investigation of the predictive value of information on the concentrations of neutrophils and lymphocytes in the peripheral blood of victims of radiation accidents in the first days (2 to 9) after exposure to predict the severity of acute radiation injury. Material and methods: Data on the post-radiation dynamics of the concentrations of lymphocytes and neutrophils in the peripheral blood of victims of the accident at the Chernobyl nuclear power plant in 1986 from the database on acute radiation injuries to humans of the A.I. Burnasyan Federal Medical Biophysical Center was used. Corr

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Ostyakova, Marina, and Svetlana Scherbinina. "BIOCHEMICAL BLOOD PARAMETERS OF PREGNANT COWS INFECTED WITH BLV." Bulletin of KSAU, no. 10 (November 26, 2024): 127–31. https://doi.org/10.36718/1819-4036-2024-10-127-131.

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The aim of the study is to investigate metabolic disorders in pregnant cows infected with bovine leukosis virus (BLV) and to determine their relationship with lymphocytic leukocytosis. The object of the study was the blood of BLV-infected cows (n = 8) and leukemia-free (n = 5) pregnant cows (2–9 years old, gestation period 2–7 months) of dairy productivity from a livestock farm in the Amur Region. In BLV-infected cows, the number of leukocytes ((17.2 ± 2.66) ∙ 109/l) and lymphocytes ((10.5 ± 2.88) ∙ 109/l) exceeded normal physiological parameters. Protein metabolism was characterized by low al

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Mionnet, Cyril, Stéphanie L. Sanos, Isabelle Mondor, et al. "High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes." Blood 118, no. 23 (2011): 6115–22. http://dx.doi.org/10.1182/blood-2011-07-367409.

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Abstract Millions of lymphocytes enter and exit mammal lymph nodes (LNs) each day, accessing the parenchyma via high endothelial venules (HEVs) and egressing via lymphatics. Despite this high rate of cellular flux and the many entry and exit sites within a given LN, the number of lymphocytes present in a resting LN is extraordinary stable over time, raising the question of how this steady-state is maintained. Here we have examined the anatomic details of lymphocyte movement in HEVs, finding that HEVs create pockets within which lymphocytes reside for several minutes before entering the LN prop

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Boscolo, P., M. Di Gioacchino, M. Cervone, F. Di Giacomo, E. Ballone, and G. Giuliano. "The Immunological Effects of Dust Containing Metals and Compounds in Workers of a Plant Producing Plastic Materials. Preliminary Study." International Journal of Immunopathology and Pharmacology 9, no. 1 (1996): 13–18. http://dx.doi.org/10.1177/039463209600900103.

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Lymphocyte subpopulations were studied in 14 men working in a plant producing plastic materials in comparison with a control group of similar age and smoking habit. The workers were exposed to dust containing particles of calcium carbonate, polyvinylchloride, phtalates, unsaturated oils, paraffin wax, iron oxides, titanium bioxides, barium, zinc, lead and lead chromate. In the exposed workers, T helper/ inducer lymphocytes (mainly CD4+-CD45RO- “virgin” lymphocytes) and CD19+ B lymphocytes were significantly reduced without changes of serum IgM, IgG and IgA. A highly significant correlation was

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Stein, Jens V., Silvia F. Soriano, Christine M'rini, et al. "CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway." Blood 101, no. 1 (2003): 38–44. http://dx.doi.org/10.1182/blood-2002-03-0841.

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Abstract Homing of blood-borne lymphocytes to peripheral lymph nodes (PLNs) is a multistep process dependent on the sequential engagement of L-selectin, which mediates lymphocyte rolling along the luminal surface of high endothelial venules (HEVs), followed by activation of lymphocyte integrins and transmigration through HEVs. Within lymphoid tissue, B and T lymphocytes then migrate toward specific microenvironments such as B-cell follicles and the paracortex, respectively. The lymphocyte-expressed chemokine receptor CCR7 is playing an important role during this process, as its HEV-presented l

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Wong, WY, DR Powars, EA Operskalski, et al. "Blood transfusions and immunophenotypic alterations of lymphocyte subsets in sickle cell anemia. The Transfusion Safety Study Group." Blood 85, no. 8 (1995): 2091–97. http://dx.doi.org/10.1182/blood.v85.8.2091.bloodjournal8582091.

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Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of granulocytes, monocytes, natural killer cells, and T-cell markers (CD2+CD11b+, CD4+CD26+, CD4+CD29+) that were significantly higher than those for control children. Percent total lymphocytes was decreased for this age group, but the total number of lymphocytes and T and B cell counts

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Kudrevich, Y. V., E. K. Kuznetsova, I. I. Dolgushin, and O. R. Ziganshin. "Assessment of the functions of cultured lymphocytes when exposed to drugs used in cosmetology." Bulletin of Siberian Medicine 21, no. 1 (2022): 63–67. http://dx.doi.org/10.20538/1682-0363-2022-1-63-67.

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The aim of the study was to determine the number of lymphocytes, intracellular cytokines produced by lymphocytes, and the cell cycle of lymphocytes isolated from the blood of patients when exposed to various drugs, as well as to assess the functions of cultured lymphocytes when exposed to drugs in vivo and in vitro.Materials and methods. The study involved lymphocytes isolated from the blood of healthy women under various conditions. At the first stage of the study, T-lymphocytes were isolated from the blood of patients before exposure to the drug. The absolute and relative lymphocyte count, t

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Machado, Heather E., Nina Friesgaard Øbro, Emily Mitchell, et al. "Life History of Normal Human Lymphocytes Revealed By Somatic Mutations." Blood 134, Supplement_1 (2019): 1045. http://dx.doi.org/10.1182/blood-2019-128188.

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Introduction: Mature blood cells harbor a mixture of mutations inherited from ancestral hematopoietic stem cells (HSCs) and mutations accumulated after maturation. The landscape of these somatic mutations in normal blood is poorly mapped, with questions as simple as "how many mutations does a memory T cell accumulate throughout life?" remaining unanswered. This gap in our knowledge is particularly relevant for hematopoietic malignancy- while we know that lymphomas derive from lymphocytes of particular stages of differentiation, we do not know if the patterns we see are reflected in their norma

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Gul, Saira, Ismat Ullah, Tooba Fateen, Noareen Tufail, and Hassan Abdal. "NEUTROPHIL LYMPHOCYTE RATIO AND PLATELETS LYMPHOCYTES RATIO WITH GLYCEMIC CONTROL IN PATIENTS WITH DIABETES MELLITUS." Journal of Akhtar Saeed Medical & Dental College 07, no. 01 (2025): 10–16. https://doi.org/10.51127/jamdcv07i01oa02.

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Background:Diabetes mellitus (DM) is a long-term health problem, which causes swelling of atissue. The Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are promising biomarkers of the blood sugar level in the type 2 diabetes mellitus (T2DM) Patients. The purpose of the study was to evaluate the relationship between NLR, PLR, and glycemic control in T2DM patients. Material and Methods: The inclusion of 102 T2DM patients who had HbA1c levels <7% and >7% was based on a cross-sectional study carried out at Allama Iqbal Medical College/Jinnah Hospital Lahore from Ma

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Kim, Jeong-A., Jinhang Kim, Saetbyeol Kim, and Misuk Yang. "Coexpression of Tim-3 and PD-1 of T Lymphocytes Prevents Acute Graft-Versus-Host Disease." Blood 142, Supplement 1 (2023): 4796. http://dx.doi.org/10.1182/blood-2023-190640.

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T lymphocytes are critical players in acute graft-versus-host disease (aGVHD). TIM3expression on the T cell surface was identified to induce immune tolerance in a mouse GVHD model; in addition, PD1 +TIM3 + double-positive T cells displayed more potent immunosuppression compared to PD1 + T cells. However, their clinical potential is greatly limited by their low cell number in peripheral blood (PB). We already introduced a novel method to obtain a high number of PD1 +TIM3 + lymphocytes that culturing CD3 + cells isolated from G-CSF mobilized peripheral blood stem cells (CD3 +G-PBSC) with human s

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K, Shubber E., Z. M. T. JAAFER, A. A. Tawfeek, and M. I. Sebbah. "Cytogenetic Analysis of Goat Blood Lymphocytes cultured in Vitro." Journal of Biotechnology Research Center 4, no. 1 (2010): 85–91. http://dx.doi.org/10.24126/jobrc.2010.4.1.101.

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The aim of this work is to determine the duration of goat cell cycling in vitro.Goat peripheral blood lymphocytes were grown in RPMI-1640 medium containing bromodeoxyuridine (BrdU 10 μg/ml) for 72 h. Blastogenic index (BI), mitotic index (MI), cell cycle progression (CCP) and sister chromatid exchanges (SCE) were determined. Cultured lymphocytes from, whole blood or from leukocyte rich plasma in RPMI-1640 medium containing BrdU showed little differences in BI, MI, but significant differences were seen in cell cycle progression. BI, MI, and CCP from different goat breed were compared. Also, the

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Silber, R., CM Farber, E. Papadopoulos, et al. "Glutathione depletion in chronic lymphocytic leukemia B lymphocytes." Blood 80, no. 8 (1992): 2038–43. http://dx.doi.org/10.1182/blood.v80.8.2038.2038.

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Abstract Glutathione (GSH) content may be the major determinant of a cell's sensitivity to cytotoxic alkylating agents. In the present study, the GSH concentration was determined in lymphocytes isolated from the blood of normal subjects and patients with chronic lymphocytic leukemia (CLL). Comparable levels were found in both types of cells. Incubation for 20 hours led to a decrease in GSH to 51% of baseline values in CLL B cells. Under the same conditions, normal B- or T-lymphocyte GSH content remained constant. GSH depletion was shown to be a characteristic of the B-CLL B lymphocyte. It was

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Silber, R., CM Farber, E. Papadopoulos, et al. "Glutathione depletion in chronic lymphocytic leukemia B lymphocytes." Blood 80, no. 8 (1992): 2038–43. http://dx.doi.org/10.1182/blood.v80.8.2038.bloodjournal8082038.

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Glutathione (GSH) content may be the major determinant of a cell's sensitivity to cytotoxic alkylating agents. In the present study, the GSH concentration was determined in lymphocytes isolated from the blood of normal subjects and patients with chronic lymphocytic leukemia (CLL). Comparable levels were found in both types of cells. Incubation for 20 hours led to a decrease in GSH to 51% of baseline values in CLL B cells. Under the same conditions, normal B- or T-lymphocyte GSH content remained constant. GSH depletion was shown to be a characteristic of the B-CLL B lymphocyte. It was not found

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Caruntu, Ana, Liliana Moraru, Mihaela Surcel, et al. "Persistent Changes of Peripheral Blood Lymphocyte Subsets in Patients with Oral Squamous Cell Carcinoma." Healthcare 10, no. 2 (2022): 342. http://dx.doi.org/10.3390/healthcare10020342.

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Background: Oral squamous cell carcinoma (OSCC) is a common cancer with high morbidity and mortality. Alterations of antitumor immune responses are involved in the development of this malignancy, and investigation of immune changes in the peripheral blood of OSCC patients has aroused the interest of researchers. Methods: In our study, we assessed the proportions of CD3+ total T lymphocytes, CD3+CD4+ helper T lymphocytes, CD3+CD8+ suppressor/cytotoxic T lymphocytes, CD3−CD19+ total B lymphocytes, and CD3−CD16+CD56+ NK cells in the peripheral blood of OSCC patients. Results: The data obtained bo

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Appel, Max J. G., Susan Pearce-Kelling, and Brian A. Summers. "Dog Lymphocyte Cultures Facilitate the Isolation and Growth of Virulent Canine Distemper Virus." Journal of Veterinary Diagnostic Investigation 4, no. 3 (1992): 258–63. http://dx.doi.org/10.1177/104063879200400306.

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Optimal conditions for the isolation and growth of virulent canine distemper virus (CDV) in canine thymic and peripheral blood lymphocyte cultures were determined. Peak virus titers were seen from 3 to 6 days postinoculation of lymphocytes and depended on the multiplicity of infection. Dog lymphocytes were at least as susceptible as canine macrophages to infection with virulent CDV. Virus replication in lymphocytes resulted in higher virus titers than in dog lung macrophages. Peripheral blood lymphocytes (PBL) from CDV-immune dogs were as susceptible to CDV as were PBL from susceptible dogs.

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Turner, James E., Jos A. Bosch, and Sarah Aldred. "Measurement of exercise-induced oxidative stress in lymphocytes." Biochemical Society Transactions 39, no. 5 (2011): 1299–304. http://dx.doi.org/10.1042/bst0391299.

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Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues and blood, including circulating lymphocytes. Lymphocytes are a very heterogeneous group of white blood cells, consisting of subtypes that have different functions in immunity. Importantly, exercise drastically changes the lymphocyte composition in blood by increasing the numbers of some subsets, while leaving other cells unaffected. This fact may

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Huang, Wenhan, FeiFeng Ren, Lei Luo, et al. "The characteristics of lymphocytes in patients positive for anti-MDA5 antibodies in interstitial lung disease." Rheumatology 59, no. 12 (2020): 3886–91. http://dx.doi.org/10.1093/rheumatology/keaa266.

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Abstract Objective The aim was to investigate the characteristics of blood lymphocytes in patients positive for anti-melanoma differentiation-associated gene 5 antibodies (anti-MDA5+) in interstitial lung disease. Methods Thirty-eight anti-MDA5+ patients with interstitial lung disease were admitted to our hospital, and the lymphocyte count, lymphocyte subtypes and lung high-resolution CT were recorded. Some of the cases were examined by bone marrow aspiration. Results Compared with the control group, the blood lymphocyte counts of anti-MDA5+ patients before treatment were significantly lower (

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