Relevant bibliographies by topics / Blood play

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Blood play'

Author: Grafiati
Published: 25 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "Blood play"

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Youn, Minyoung, Hee-Don Chae, Jesus Omar Gomez, and Kathleen M. Sakamoto. "Pp90RSK Isoforms Play Distinct Roles during Hematopoiesis." Blood 136, Supplement 1 (2020): 13. http://dx.doi.org/10.1182/blood-2020-142251.

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Ribosomal S6 Kinases (RSKs) include a family of serine/threonine kinases that regulate cell proliferation and survival. In humans, four RSK isoforms (RSK1-4) have been identified. Although they are 73-80% conserved in sequence homology, RSK isoforms are reported to have distinct functions. RSKs phosphorylate cyclic AMP response element binding protein (CREB) which is a regulator of hematopoietic proliferation and differentiation. RSK1 is hyperactivated in AML and is therefore a potential therapeutic target for acute myeloid leukemia (AML). Therefore, inhibition of RSK requires understanding of
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Kipps, Thomas J. "MicroRNAs play a role in neoplasia." Blood 109, no. 12 (2007): 5071–72. http://dx.doi.org/10.1182/blood-2007-04-081786.

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Ahn, Yeon S. "Triple play of H pylori in ITP." Blood 115, no. 21 (2010): 4155–56. http://dx.doi.org/10.1182/blood-2010-02-269720.

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Au, Sam H. "Drug smuggling microparticles play dress-up." Science Translational Medicine 10, no. 452 (2018): eaau7382. http://dx.doi.org/10.1126/scitranslmed.aau7382.

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Sharma, Balkrishan, Allison Remiker, Brenton Francisco, et al. "Fibrin and Fibrinogen Play Complex Opposing Roles in Metastasis." Blood 144, Supplement 1 (2024): 1194. https://doi.org/10.1182/blood-2024-211581.

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Fibrin(ogen) has been identified as a major determinant of metastatic potential. However, it remains to be determined whether fibrinogen, fibrin polymer, or both is the molecular form of the protein conferring metastatic modifying activity. Here, metastatic potential was compared in C57BL/6-derived control mice (FgaWT), mice with fibrinogen deficiency (Fga-/-), and mutant mice carrying a form of fibrinogen locked in a nonpolymerizable state due to mutation of the native α chain thrombin cleavage site (FgaEK). We first performed experimental metastasis assays using the C57BL/6-derived tumor cel
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Kahn, Mark L. "Platelet collagen receptors play molecular ping-pong." Blood 103, no. 4 (2004): 1180–81. http://dx.doi.org/10.1182/blood-2003-11-4080.

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Borges, Kelly, Alexander Rothstein, Peter Douris, et al. "Blood Flow In Extended ESport Play: A Pilot Study." Medicine & Science in Sports & Exercise 55, no. 9S (2023): 627. http://dx.doi.org/10.1249/01.mss.0000985676.45494.63.

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Walzer, Thierry. "NK-cell education: KIR-S come into play." Blood 115, no. 6 (2010): 1110–11. http://dx.doi.org/10.1182/blood-2009-11-254953.

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Abstract In this issue of Blood, Fauriat and colleagues find that the expression of KIR2DS1 by human NK cells is associated with a decreased responsiveness to various stimuli in HLA C2/C2 but not in C1/C1 persons.
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Arun Kumar, Sumukh, Ankushi Sanghvi, Maya Gogtay, Harshit Khosla, Susan V. George, and Ahmad Daniyal Siddiqui. "Did Physicians Have a Role to Play in National Blood Crisis?" Blood 140, Supplement 1 (2022): 7883–84. http://dx.doi.org/10.1182/blood-2022-160184.

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Fauriat, Cyril, and Daniel Olive. "AML drug resistance: c-Myc comes into play." Blood 123, no. 23 (2014): 3528–30. http://dx.doi.org/10.1182/blood-2014-04-566711.

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Dissertations / Theses on the topic "Blood play"

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Freeman, Grant HS. "A Pact Sealed in Blood: The Creation of Blood Letters: An American Odyssey." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3630.

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A Pact Sealed in Blood: The Creation of Blood Letters: An American Odyssey is a reflection on the project, writing, script and production phases of a student researched and written theatrical script, which debuted in the Shafer Street Playhouse on April 24, 2014 on the campus of Virginia Commonwealth University. This paper looks at the processes involved with the creation of that piece. The theatrical piece tells the tales of three men over the course of 150 years as each man goes through his own personal crucible. The first fights for his country and his family during the American Civil War.
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Chesi, Giulia Maria. "The play of words : blood ties and power relations in Aeschylus' Oresteia." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609728.

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Marsden, Katelyn Randi Lee. "Cerebral blood flow velocity : does it play a role in symptom exacerbation during exercise in concussed athletes?" Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45239.

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Exercise frequently results in exacerbation of symptoms following a sports-related concussion (SRC). However, the mechanism(s) behind this phenomenon has yet to be determined. It is possible that an inability to regulate cerebral blood flow (CBF) may lead to over-perfusion, and thus cause the exacerbation of symptoms seen during exercise. It was hypothesized that: 1) CBF velocity during exercise will be greater in SRC. 2) Severity of symptoms will be correlated with CBF velocity during exercise and 3) day-to-day variability in CBF velocity will be greater in SRC compared to control subjects. S
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Carneiro, Esteves Sophie. "Segmentation des vaisseaux sanguins par approche variationnelle et apprentissage profond." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2024. http://www.theses.fr/2024UCFA0034.

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La segmentation des vaisseaux sanguins à partir d'images médicales est une étape cruciale dans diverses applications cliniques, telles que la planification chirurgicale, le diagnostic des maladies et le suivi des traitements. Cependant, elle reste un défi en raison de la diversité des modalités d'imagerie, de la géométrie complexe des structures et du faible contraste des images biomédicales. L'apprentissage profond fournit une puissance de représentation importante pour apprendre une fonction qui permet l'obtention d'une segmentation précise. Néanmoins, même avec le développement de méthodes
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Lynch, Dorine A. "Basic Quality Care Blood Pressure Teaching Plan." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7821.

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Hypertension (HTN) is a leading risk factor for cardiovascular disease complications, disability, and mortality. Delayed detection of HTN increases the risk of the patient developing heart disease, renal failure, and stroke, which are among the leading causes of death in the US. Educating healthcare providers is, therefore, necessary to ensure accuracy when measuring blood pressure (BP) to improve the likelihood of early detection and commencement of treatment. The BP teaching project involved the development of an evidence-based teaching program to educate nurses at an East Coast Veterans' Ad
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González, Luis Gabriel, and Quintana Gonzalo Iván Morales. "De Bloom." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/143189.

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TESIS PARA OPTAR AL GRADO DE MAGÍSTER EN ADMINISTRACIÓN Luis Gabriel Gonzélez [Parte I], Gonzalo Iván Morales Quintana [Parte II]<br>El presente documento tiene por objetivo describir el plan de negocios para el desarrollo de un canal de venta minorista de flores para regalo “De Bloom”. El modelo de negocios se apunta a la venta de flores envasadas a través de una tienda virtual y tiendas físicas ubicadas en pasillos de malls. La industria de las flores en Chile se caracteriza por su gran tamaño (aproximadamente USD 70 millones), una gran cantidad de competidores poco profesionalizado
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Lees-Jeffries, Hester M. M. "Tragedies of blood : The significance of the family in five Renaissance plays." Thesis, University of Canterbury. English, 1998. http://hdl.handle.net/10092/7059.

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In this thesis, I examine the functions and significance of the family in five English tragedies from the period 1607-30. Drawing on Renaissance texts in which the family is employed as the fundamental analogue of social and moral order, I argue that the prominence of the family in these plays attests to an enduring belief in the need for order and structure in society, which their sensationalist depictions of depravities such as adultery, incest, bastardy and murder should not be allowed to obscure. In doing so, I reject criticism which regards these plays' view of human nature and society as
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Ycka, Salgado Yarmila Elizabeth. "Plan Comercial Internacional para la Tecnología SIMBAS (Self-Powered Integrated Microfluidic Blood Analysis System)." Tesis, Universidad de Chile, 2010. http://repositorio.uchile.cl/handle/2250/102360.

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El objetivo del presente informe es realizar un plan de comercialización para el dispositivo SIMBAS (Self-powered Integrated Microfluidic Blood Analysis System), el cual se encuentra en etapa de prueba y adquisición de patentes, en Reino Unido y Estados Unidos. Este dispositivo se asocia a la industria de las tecnologías Point of Care (POC). Los diagnósticos POC están orientadas al diagnóstico al lado del paciente, profesional o en cualquier sitio distinto del laboratorio clínico. La base es el diagnóstico rápido oportuno con resultados en tiempo real que permitan tomar decisiones clínic
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Schreiber, Dale. "The role that blood sacrifice plays in the Worodougou practice of the religion of Islam." Theological Research Exchange Network (TREN), 1998. http://www.tren.com.

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Lundberg, Martin. "Optimization of the multiplexed Proximity Ligation Assay for detection of blood-based biomarkers." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223943.

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The Proximity Ligation Assay (PLA) is a relatively new method which utilizes the strength of both immunoassays and DNA detection. PLA has the capacity of high multiplexing due to the high specificity achieved with both dual protein-binding and dual primer binding during detection with Real-Time PCR. We developed a multiplexed PLA protocol that can measure 28 biomarkers in human EDTA plasma. The method was tested on 46 individuals diagnosed with colorectal cancer and 48 age matched healthy controls. The results are very promising as we re-discover the most well-known biomarkers for colorectal c
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Books on the topic "Blood play"

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Bains, Harwant S. Blood: A play. Methuen Drama, 1989.

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Izuora, Ozioma. Blood for palm-wine: A play. Delta Publications (Nigeria) Limited, 2009.

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Izuora, Ozioma. Blood for palm-wine: A play. Delta Publications (Nigeria) Limited, 2009.

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Fugard, Athol. Blood knot: A play in seven scenes. S. French, 1989.

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Brent, Laytham D., ed. God does not--: Entertain, play matchmaker, hurry, demand blood, cure every illness. Brazos Press, 2009.

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Delaney, Shelagh. A taste of honey: A play. Methuen, 1993.

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Koste, Virginia Glasgow. White as snow, red as blood: The story of Snow White, a play in seven scenes. New Plays Incorporated, 1992.

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National AIDS Control Organization (India), ed. An action plan for blood safety. National AIDS Control Organisation, Ministry of Health & Family Welfare, Govt. of India, 2003.

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Rossmore, James L. Plan Colombia: Blood and drugs. Anthem, 2001.

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Fugard, Athol. Blood knot, and other plays. Theatre Communications Group, 1991.

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Book chapters on the topic "Blood play"

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Hughes, Luke, and Stephen David Patterson. "Blood Flow Restriction Training and Return to Play Following Knee Surgery." In Knee Arthroscopy and Knee Preservation Surgery. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-030-82869-1_74-1.

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Hughes, Luke, and Stephen David Patterson. "Blood Flow Restriction Training and Return to Play Following Knee Surgery." In Knee Arthroscopy and Knee Preservation Surgery. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-29430-3_74.

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Berre, Nanna, Gabriela Castro, Henrik Kjeldsberg, Rami Masri, and Ingeborg Gjerde. "A Computational Study of Flow Instabilities in Aneurysms." In Computational Physiology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-05164-7_6.

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AbstractThe majority of hemorrhagic strokes are caused by cerebral aneurysms, harboured in a large portion of the human population. Currently, it is unclear what constitutes a dangerous aneurysm, and the risk of rupture of such aneurysms is challenging to quantify. Previous studies have shown that flow dynamics play an important role in the development of aneurysms. However, there is varying consensus on blood flow patterns and stability. In this work, we formulate a Reynolds–Orr method to quantify the stability of blood flow in arteries. Applying this method to blood flow in four different ar
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Kandemir, Emre. "Sexual Dysfunction on Diabetes Mellitus." In Current Perspective on Diabetes Mellitus in Clinical Sciences. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359111.6.

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Sexual dysfunction is a prevalent complication among individuals with diabetes mellitus, affecting both men and women. In men, diabetes can lead to erectile dysfunction due to damage to blood vessels and nerves that regulate blood flow to the penis. Additionally, decreased testosterone levels and psychological factors like stress or depression contribute to this issue. Women with diabetes often experience reduced sexual desire, decreased vaginal lubrication, and difficulty achieving orgasm. Similar to men, nerve damage, hormonal imbalances, and psychological factors play significant roles in s
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Clout, Ruth, John Murray, Maria Farrell, Daphna Hutt, and Michelle Kenyon. "Cell Therapy, Nursing Implications and Care." In The European Blood and Marrow Transplantation Textbook for Nurses. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23394-4_7.

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AbstractOver recent years cellular therapy has seen substantial progress across Europe, particularly cell-based immunotherapy/ immune effector cells (IECs), with the approval of autologous CD19 CAR-T products for patients with relapsed/refractory B-cell malignancies-diffuse large B cell lymphoma, acute lymphoblastic leukaemia (paediatric, teenage and young adult) and mantle cell lymphoma). Whilst this development has delivered benefit to patients with poor risk disease, there is potential for associated toxicities which require careful patient selection, assessment, monitoring, treatment and f
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Algul, Sermin, and Oguz Ozcelik. "Physiology of Pulmonary Circulation & Related Structures." In Pulmonary Circulation Related Structures. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358886.3.

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The pulmonary circulation, which includes the movement of blood from the heart to the lungs and back, facilitates gas exchange and serves several other functions. It differs from systemic circulation but is crucial for maintaining homeostasis. Pulmonary vessels protect against thrombi and emboli, metabolize vasoactive hormones, and act as a blood reservoir. Hemodynamically, pulmonary circulation is characterized by high flow, low pressure, and low resistance. Pulmonary vascular resistance adjusts to changes in cardiac output and lung volume, impacting gas exchange efficiency. Hypoxia can induc
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Pohlmann, Andreas, Kaixuan Zhao, Sean B. Fain, Pottumarthi V. Prasad, and Thoralf Niendorf. "Experimental Protocol for MRI Mapping of the Blood Oxygenation-Sensitive Parameters T2* and T2 in the Kidney." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0978-1_23.

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AbstractRenal hypoxia is generally accepted as a key pathophysiologic event in acute kidney injury of various origins, and has also been suggested to play a role in the development of chronic kidney disease. Here we describe a step-by-step experimental protocol for indirect monitoring of renal blood oxygenation in rodents via the deoxyhemoglobin sensitive MR parameters T2* and T2—a contrast mechanism known as the blood oxygenation level dependent (BOLD) effect. Since an absolute quantification of renal oxygenation from T2*/T2 remains challenging, the effects of controlled and standardized vari
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Cetik Yildiz, Songul. "Brain and Cytokines." In Brain Biochemistry and Its Disease. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359371.6.

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Cytokines are low molecular weight glycoproteins that play a role in cell maturation, differentiation, inflammation, immunity and tissue repair. Cytokines are responsible for the propagation of the neuroinflammatory response as well as an indicator of the presence of the neuroinflammatory response. Although the neuroprotective and neurotrophic effects of cytokines have been demonstrated, it is well known that they are necessary for nerve development and maintenance of normal central nervous system functions. Cytokines reach the brain: Cytokines may be passively transported to brain cells from
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Gunes Kocinkag, Vezire, and Muhammed Kocinkag. "Medical Use of Cardamom (Elettaria Cardamomum L.)." In Medicinal Spices. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053359340.15.

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Cardamom (Elettaria cardamomum L.) is a spice that is widely used especially in Asian cuisine and is also valuable for medicinal purposes. Thanks to the active ingredients it contains, Cardamom supports digestive health and can relieve stomach discomfort. Additionally, it has antioxidant properties and can reduce inflammation, thus having anti-inflammatory effects. Some research shows that cardamom has the ability to balance blood sugar levels, suggesting it may play a potential role in diabetes management. Additionally, cardamom has antimicrobial properties and can therefore be used to suppor
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Kurysheva, Natalia I., Vitaliy Yu Kim, and Valeria E. Kim. "Does the Evaluation of Ocular Blood Supply Play a Role in Glaucoma Diagnostics and Prognosis of Progression?" In Predictive, Preventive, and Personalised Medicine: From Bench to Bedside. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-34884-6_18.

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Conference papers on the topic "Blood play"

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Ashbarry, Louise, Benjamin Geelan, Kristy de Salas, and Ian Lewis. "Blood and Violence." In CHI PLAY '16: The annual symposium on Computer-Human Interaction in Play. ACM, 2016. http://dx.doi.org/10.1145/2967934.2968111.

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AlMomani, T., H. S. Udaykumar, J. Marshall, and K. B. Chandran. "Dynamic Simulation of Red Blood Cells/Platelet Interaction in Arteriolar Blood Flow." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-175290.

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Hemodynamic forces have been proposed as a major factor in thrombosis (thrombus formation) in the human cardiovascular system [1]. It has been suggested that platelet activation, aggregation and adhesion to the surface of the implants result in the formation of the mural thrombi [2]. Red blood cells (RBCs) are thought to play a significant role in the dynamics and the activation of the platelets and hence thrombus formation in the human arterial system. Previous experimental works indicate that RBCs cause platelets to migrate and move toward the vessel walls [3]. Thrombus formation has also be
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A. ABDULMEER, Hanaa, Saba A.ALI, and Alyaa ISAM. "THE SIGNIFICANCE OF COMPLETE BLOOD BLOOD COUNT AS LABORATORY DIAGNOSIS IN COVID-19." In IV.International Scientific Congress of Pure,Appliedand Technological Sciences. Rimar Academy, 2022. http://dx.doi.org/10.47832/minarcongress4-22.

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The increased global prevalence of COVID-19 has resulted in a significant increase in the occupancy rate of healthcare facilities, resulting in overcrowding in some areas. In this situation, healthcare staff must efficiently assess patients' status and undertake risk stratification, particularly in a triage setting. The complete blood count is a easily available, cost-effective, and time-saving testing procedure that may be useful in supporting those processes. This review examines changes in complete blood count parameters in COVID-19 patients with the goal to identify the most common changes
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Yano, K., and T. Yamaguchi. "Computational Mechanical Simulation of the Aggregation and Dissociation of Platelets Mediated by von Willebrand Factor." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32575.

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Platelets play an important role in blood coagulation, particularly in the formation of primary thrombi. The aggregation of platelets, which initiates primary thrombi formation, is thought to be mediated by the von Willebrand factor (vWF). The vWF is a long-chain macromolecule that exists in a soluble form in the blood flow and an insoluble form in the vessel wall. Figure 1 schematically shows normal (a) and pathological (b) thrombus formation processees. In both cases, platelets adhere to the injured vessel wall and then form a thrombus in cooperation with the fibrin network, red cells, and o
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Riva, Charles E., Ralph Zuckerman, Benno L. Petrig, and Juan E. Grunwald. "Noninvasive Assessment of Retinal Macular Capillary Blood Flow Regulation." In Noninvasive Assessment of the Visual System. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/navs.1987.wc4.

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Quantitative determination of retinal blood flow and its regulation is fundamental to an understanding of the pathophysiology of the retinal vascular system and to an objective evaluation of the effect of treatment. Of particular importance is the quantification of blood flow in the capillaries, where the exchange of nutrients and waste products takes place. For example, impairment of this exchange is believed to play an important role in the development of diabetic retinopathy, a disease which often results in severe visual loss.
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Miyazaki, Hisako, Hao Liu, and Takami Yamaguchi. "Computational Mechanical Analysis of the Platelets Behavior in the Blood Flow Using Discrete Element Method." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2534.

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Abstract Platelets play an important role in blood coagulation, particularly in the formation of primary thrombi. It is thought that the aggregation of platelets, which initiates primary thrombi formation, is mediated by a macromolecule called von Willebrand Factor (vWF). vWF is a long chain macromolecule that exists in the blood flow as a soluble form and in the vessel wall as an insoluble form. Figure 1 schematically shows normal (a) and pathological (b) thrombus formation processes as illustrated by Ikeda (1998) In both cases, platelets adhere to the injured vessel wall and then form a thro
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Yano, Koichiro, Daisuke Mori, Ken-ichi Tsubota, Takuji Ishikawa, Shigeo Wada, and Takami Yamaguchi. "Effect of the Red Blood Cells on the Primary Thrombus Formation." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176360.

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It has been pointed out that some mechanical factors play important roles in a series of physiological or biochemical processes during the thrombus formation. Recently, many studies including the authors’ work qualitatively demonstrated how the thrombus is regulated under the influences of the blood flow and the intercellular molecular bridge using computational fluid dynamics techniques[1–4]. They verified the importance of the balance of them in the process of the thrombus formation. However, few studies have taken into account the existence of the other cell constituents than the platelet s
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AlMomani, T. D., S. C. Vigmostad, H. S. Udaykumar, and K. B. Chandran. "Modeling of Red Blood Cell Dynamics Using Fluid Structure Interaction (FSI) Technique." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19039.

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Red blood cells (RBCs) or erythrocytes are biconcave disks with diameter of 8μm and thickness of 2 μm. RBC can be considered as a nucleus free deformable capsule enclosed by a flexible membrane and consisting of an incompressible viscous fluid [8, 9]. The deformation of RBCs is thought to play a major role in both RBC dynamics and functionality. Previous studies have indicated that two important characteristics related to deformation of the RBC [1]: i) the interior of the RBC is a liquid state that surrounded by an elastic membrane, ii) the biconcave shape of the RBC enables it to deform into
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Furukawa, Toshiki, Takuro Sakagami, Asako Takiguchi, et al. "Th17 Cells In Peripheral Blood Play Pivotal Roles In Development Of Non-Eosinophilic Asthma Independent Of Th1/Th2 Paradigm." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3944.

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Stephen, Beth, Theresa A. Good, Joseph B. Washington, and L. D. Timmie Topoleski. "The Effect of Oxidation on the Mechanical Response of Elastin Isolated From Porcine Aorta." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53147.

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Arteries play a critical role in human health, and consequently are extensively studied as a biological component. However, the primary function of arteries is mechanical; they conduct blood through the body. Therefore, arteries, and their structure-function relationships, must also be studied as biomaterials.
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Reports on the topic "Blood play"

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Tschoellitsch, Thomas, Martin Dünser, Matthias Noitz, and Michael Türk. Clinical indicators of systemic tissue hypoperfusion (‘shock’): A protocol for a systematic review and qualitative analysis of the literature. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.12.0047.

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Review question / Objective: The objective of this review is to identify the current scientific evidence on the value of clinical signs to indicate systemic tissue hypoperfusion or shock. Condition being studied: In the literature and clinical studies, shock has traditionally been defined by a drop in arterial blood pressure under a critical threshold, e.g., a systolic blood pressure of 90 mmHg, a mean arterial blood pressure &lt;65 mmHg or a relative drop in systolic blood pressure of ≥40 mmHg. From a pathophysiologic point of view, shock relates to an imbalance between tissue oxygen delivery
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Avihingsanon, Yingyos, Jongkonnee Wongpiyabovorn, and Nattiya Hirankarn. Biomarker discovery in systemic lupus erythematosus: genome-methylation approaches : Research report. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.15.

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Discovery of novel biomarkers in lupus nephritis Biomarkers are needed for making diagnosis and prognosis. In lupus nephritis, conventional tests like urinalysis or serum creatinine remain inadequate for patient care. In this proposal, we focused on non-invasive tools like blood and urine mRNAs or proteins. We chose candidate genes involving regulatory T-cell, B-lymphocyte signatures or vascular protective factors. Expression of regulatory cell signature (FOXP3) in peripheral blood mononuclear cells is associated with activity of lupus nephritis. We found FOXP3 mRNA levels in PBMCs from patien
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Osorio, Itzel, Camillie Delevaux, Ricardo Perez-Cuevas, et al. Associated Factors of Healthy Lifestyle in the Bahamas. Inter-American Development Bank, 2018. http://dx.doi.org/10.18235/0009376.

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The Bahamas faces critical challenges due to an increase in chronic diseases (CDs). Overweight and obesity are on the rise among all age groups. In addition, the prevalence of raised blood glucose is 13% and that of high blood pressure is 31%. CDs are responsible for 45% of deaths in the country. The Ministry of Health has been implementing programs and interventions to slow the growth of CDs. These programs focus on tackling risk factors and developing both the National Dietary Guidelines and the nutrition interventions implemented in primary care facilities and in the community. This study i
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ทองจุล, ณัฏฐา, อภิชาติ กาญจนทัต, ฤทัยรัตน์ บุญสมบัติ та นันทิกา คงเจริญพร. โครงการนำร่องพลาสเตอร์ชีวภาพสำหรับห้ามเลือด : รายงานการวิจัย. Chulalongkorn University, 2005. https://doi.org/10.58837/chula.res.2005.78.

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In this study, polylactic acid (PLA) was synthesized via direct polycondensation. The effects of catalyst, temperature, pressure, and solvent system on PLA properties were observed. Synthesized PLA was blended with polycaprolactone (PCL) and chitosan (CHI) and was casted into the blended film. The film was used to construct a biodegradable device for controlled delivery of active ingredient with hemostatic activity to speed up blood clotting and at the same time providing the network where fibrin-based clot formed.
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กาญจนทัต, อภิชาติ. โปรตีนไฮโดรไลเสตจากเมล็ดผลไม้ไทยเพื่อการบำบัดโรค : รายงานวิจัยฉบับสมบูรณ์ (ปีที่ 1). จุฬาลงกรณ์มหาวิทยาลัย, 2014. https://doi.org/10.58837/chula.res.2014.89.

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Blood pressure regulation is partially dependent on the renin-angiotensin system; renin acts on angiotensinogen to release angiotensin-I, which is further converted into the angiotensin II by the angiotensin I-converting enzyme (ACE). ACE plays a key physiological role in the regulation of blood pressure by virtue of two different reactions that it catalyzes: conversion of the inactive angiotensin I to the powerful vasoconstrictor angiotensin II, and inactivation of the vasodilator bradykinin. Crude extract and ammonium sulphate cut protein extracts, and their pepsin-pancreatin hydrolysates, f
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Eldar, Avigdor, and Donald L. Evans. Streptococcus iniae Infections in Trout and Tilapia: Host-Pathogen Interactions, the Immune Response Toward the Pathogen and Vaccine Formulation. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575286.bard.

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In Israel and in the U.S., Streptococcus iniae is responsible for considerable losses in various fish species. Poor understanding of its virulence factors and limited know-how-to of vaccine formulation and administration are the main reasons for the limited efficacy of vaccines. Our strategy was that in order to Improve control measures, both aspects should be equally addressed. Our proposal included the following objectives: (i) construction of host-pathogen interaction models; (ii) characterization of virulence factors and immunodominant antigens, with assessment of their relative importance
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Wongpiyabovorn, Jongkonnee, Nattiya Hirankarn, Yingyos Avihingsanon, Tewin Tencomnao, Yong Poovorawan, and Kriangsak Ruchusatsawat. The association between immunogenetics and genetic susceptibility of psoriasis in Thai population. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.27.

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Psoriasis is T-cell-mediated skin autoimmunity, required environmental triggers and genetic susceptibility factors to become manifested. Psoriasis is a chronic skin disease characterized by the abnormal hyperproliferation and differentiation of the epidermis, elongated and prominent blood vessels and a thick perivascular lymphocytic infiltrate. Vascular endothelial growth factor (VEGF) gene play important role in pathogenesis of various diseases with angiogenic basis such as breast cancer and autoimmune disease including psoriasis. Many studies analyzed the association of VEGF gene polymorphis
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Zhao, Fangfang, Chunli Lu, Luying Chen, et al. Red yeast rice preparations for dyslipidemia: A protocol for an overview of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.3.0032.

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Review question / Objective: What is the quality of systematic reviews/meta-analysis of red yeast rice (RYR) preparations for dyslipidemia? What is the comparative benefit of red yeast rice preparations on dyslipidemia compared to other lipid-lowering drugs? Based on the current controversies in dyslipidemia guidelines and clinical practice, to explore the relative benefits of red yeast rice compared with other lipid-lowering drugs, we plan to perform an overview of existing SRs/MAs. Condition being studied: Red yeast rice (RYR) has been used as an alternative to statin therapy in treating pat
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Patumraj, Suthiluk, and Sheepsumon Viboolvorakul. Protective effects of exercise training against vascular and neuronal dysfunction in aging brain. Department of Physiology, Faculty of Medicine, Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.11.

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During advancing age, reduction of microvessels in the brain contributes insufficiency tissue perfusion. Mounting evidence indicates that microvascular deterioration in aged brain relates to oxidative stress. Nuclear factor erythroid-related factor 2 (Nrf2) plays an important role in cellular antioxidant defense. Regular physical exercise is well known to have beneficial effect to brain health, including promoted blood flow and augmented angiogenesis, in aging individuals. However, the underlying mechanism of regular physical exercise in improvement of brain microvascular density during advanc
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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture indu
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