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Dissertations / Theses on the topic 'Blood pressure regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Johnson, J. V. "Vasopressin and blood pressure regulation in the rat." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376525.

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2

Galla, Sarah L. "Studies on the Holobiont and Blood Pressure Regulation." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556099980339015.

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3

Peirce, Susan Caroline. "Investigating short-term blood pressure regulation : peripheral baroreceptor sensitivity." Thesis, University of Leicester, 2006. http://hdl.handle.net/2381/29891.

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Autonomically-mediated baroreflex control of heart rate has been extensively studied (cardiac BRS, cBRS), but peripheral control of blood pressure is less well known. Total peripheral resistance (TPR) was derived from pulse contour stroke volume (SVPC) using non-invasive blood pressure (Finapres). The beat-to-beat variability of Finapres SVPC was evaluated in cardiac catheterisation patients against aortic blood pressure SVPC. Correlations were generally good (mean R = 0.75), but regression slopes tended to be less than unity and several aortic recordings were significantly affected by the dyn

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4

Ashraf, Usman Mohammad. "Novel Regulators of Kidney Homeostasis and Blood Pressure Regulation." University of Toledo Health Science Campus / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=mco1596206028212986.

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5

Correia, Anabela G. 1975. "The renal medullary circulation and blood pressure control." Monash University, Dept. of Physiology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8480.

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6

Lopez, Kyle Eric, and Kyle Eric Lopez. "Uncovering Signal Transduction in Blood Pressure Regulation by Nitric Oxide." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625045.

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Nitric Oxide (NO) is an important signaling molecule in blood pressure regulation. The NO receptor, soluble guanylate cyclase (sGC), produces the secondary messenger cGMP in response to NO binding. Because of its role in blood pressure regulation, sGC is increasingly targeted for drug discovery and several new drugs treating hypertensive individuals are sGC stimulators. Unfortunately, stimulator development is limited by our understanding of NO and simulator induced conformational changes. In the present study, we used lanthanide resonance energy transfer (LRET) to measure distances betw

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7

Huang, Chunhua. "Impact of dietary salt intake during growth on cardiovascular homeostasis and neural control of the kidney : role of brain angiotensin II (Ang II)." Thesis, University of Birmingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368519.

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8

Rees, Daryl David. "The role of nitric oxide in the cardiovascular system." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293301.

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Nitric oxide is generated by the vascular endothelium from L-arginine by a constitutive, Ca2+-dependent, NO synthase. Analogues of L-arginine were characterised as inhibitors of NO synthase to investigate the biological significance of the L-arginine-NO pathway in the vessel wall and its role in the cardiovascular system. These inhibitors attenuate the endothelium-dependent vasorelaxation and hypotension induced by various agents, produce an increase in vascular tone and an increase in blood pressure. This suggests that NO is involved in endothelium-dependent relaxation and its continuous rele

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9

Muzs, Karolin. "The influence of short chain fatty acids on blood pressure regulation." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=236055.

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Hypertension is a widespread condition which may cause cardiovascular events when left untreated. If high blood pressure (BP) is noticed at all, it is mostly only sub-optimally controlled making nutritional interventions a cost-effective and safe preventive measure and an alternative to medical treatment. Previous studies have shown that increased fibre consumption reduces BP which was particularly effective in hypertensive subjects. Fibres are indigestible and hence are available for fermentation by the colonic microbiota which produces the short chain fatty acids (SCFAs) acetate, propionate

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10

Rahsid, Imad Hatim. "Role of C1-adrenergic neurones in the regulation of vasopressin and pressor response." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294526.

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11

Hammad, Sally. "The role of PMCA1 in blood pressure regulation and the development of hypertension." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-pmca1-in-blood-pressure-regulation-and-the-development-of-hypertension(61b800d1-26a5-44ae-8d50-5e72676c555e).html.

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Introduction: Hypertension is a complex disease that affects about 40% of adults worldwide, and is a major risk factor for cardiac hypertrophy and heart failure. Abnormal calcium handling plays a key role in hypertension and cardiovascular disease. In order to function normally cells of the cardiovascular system need to keep intracellular Ca2+ levels under tight control. This is achieved by a number of Ca2+ handling proteins including the plasma membrane Ca2+-ATPase (PMCA). Recent genome wide association studies have shown that single nucleotide polymorphisms in ATP2B1, the gene encoding PMCA1

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12

Ng, Fu Liang. "The impact of the blood pressure-associated genetic locus at SLC4A7 on gene expression and intracellular pH regulation." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24732.

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Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/HCO3 - co-transporter NBCn1 which regulates intracellular pH (pHi) in a range of tissues, including vascular smooth muscle and endothelium. Notably, the SLC4A7 knockout mouse has been shown to have an altered blood pressure phenotype. This thesis presents a functional study of variants at this locus in primary cultures of vascular smooth muscle and endothelial cells. There were genotype-dependent differences in DNA-nuclear protein interact

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13

Henker, Richard. "PNEUMATIC ARTIFICIAL HEART DRIVER PARAMETER EFFECTS ON THE RATE OF PRESSURE CHANGE ((+) DP/DT MAX)." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276466.

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The aim of the research was to investigate the effects of three parameters of the artificial heart on the (+) dP/dt max. The study was conducted using a mock circulation which was connected to an artificial heart. The data were collected using the COMDU software developed for the computer which monitors the artificial heart. Stepwise regression analysis was utilized to test the three hypotheses. Two of the null hypotheses for the study could not be rejected, as the independent variable did not significantly affect (+) dP/dt max. Although the third hypothesis was accepted, the results were not

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14

Loudon, Mary. "Arterial wall renin-like activity and blood pressure regulation in the rat." Thesis, University of Leicester, 1985. http://hdl.handle.net/2381/34141.

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In this study the Importance of the generation of angiotensin II within the blood vessel wall in determining the pressor response to injected renin was investigated. An injection of renin, given to rats after bilateral nephrectomy, produced a pressor response. The level of circulating renin, although initially elevated, returned to the normal range within three hours. However, the level of renin present in the aortic wall remained significantly elevated for six hours after the injection, as did the pressor response. Infusions of the angiotensin II antagonist saralasin at three and six hours af

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15

Stevens, Glen Harold John. "Blood Pressure Regulation During Simulated Orthostatism Prior to and Following Endurance Exercise Training." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc277914/.

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Cardiovascular responses and tolerance to an orthostatic stress were examined in eight men before and after eight months of endurance exercise training. Following training, maximal oxygen consumption and blood volume were increased, and resting heart rate reduced. Orthostatic tolerance was reduced following training in all eight subjects. It was concluded that prolonged endurance training decreased orthostatic tolerance and this decrease in tolerance appeared associated with attenuated baroreflex sensitivity and alterations in autonomic balance secondary to an increased parasympathetic tone no

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16

Myredal, Anna. "Cardiovascular regulation and vascular structure in prehypertension and coronary heart disease /." Göteborg : Dept. of Molecular and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, 2009. http://hdl.handle.net/2077/20809.

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17

Wiemuth, Dominik, and n/a. "Regulation of the epithelial sodium channel (ENac) by ubiquitination." University of Otago. Department of Physiology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20061127.162243.

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The epithelial sodium channel (ENaC) is the central component of the sodium absorption pathway in epithelia. It is critical for sodium homeostasis and blood pressure control, which is demonstrated by rare genetic disorders such as Liddle�s syndrome and pseudohypoaldosteronism type I, that are associated with hyper- and hypotension, respectively. ENaC is mainly regulated by mechanisms that control the expression of active channels at the cell surface. Ubiquitin ligases of the Nedd4-like family, such as Nedd4 and Nedd4-2 decrease epithelial sodium absorption by binding to and targeting ENaC fo

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18

Raine, Neil Martin. "Cardiovascular adjustments and blood pressure regulation immediately following dynamic exercise in normotensive men." Thesis, Liverpool John Moores University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388524.

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19

Hendy, Emma Bernice. "Sites and mechanisms within the brainstem for chronic regulation of arterial blood pressure." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528103.

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20

Brennan, Kathryn. "Maternal nutrient restriction alters renal development and blood pressure regulation of the offspring." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439999.

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21

Carr, Fiona Jane. "Investigation into genetic determinants of blood pressure regulation in a model of hypertension." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250065.

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22

Dunlop, Diana Clare. "Calcium homeostasis and blood pressure regulation in normal and insulin-dependent diabetic pregnancy." Thesis, University of Bath, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311185.

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23

Andresen, Jean M. "Aortic Baroreceptor Reflex Control of Blood Pressure: Effect of Fitness." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc500922/.

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Aortic baroreflex (ABR) control of blood pressure was examined in 7 untrained (UT) and 8 endurance exercise trained (EET) young men. ABR control of blood pressure was determined during a steady state phenylephrine infusion to increase mean arterial pressure 10-15 mmHg, combined with positive neck pressure to counteract the increased carotid sinus transmural pressure, and low levels of lower body negative pressure to counteract the increased central venous pressure. Functioning alone, the ABR was functionally adequate to control blood pressure. However, ABR control of HR was significantly dimin

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24

Baker, Nigel Richard. "Synthesis and pharmacological activity of novel quinolones, benzopyran-4-ones and fluorobenzenes as potential cardiovascular agents." Thesis, Coventry University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245099.

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25

SATHER, TOM MALVIN. "MECHANISMS OF CARDIOVASCULAR ADJUSTMENTS ASSOCIATED WITH PRESYNCOPAL-LIMITED LOWER BODY NEGATIVE PRESSURE TOLERANCE (ORTHOSTASIS)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188096.

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In man, tolerance to an orthostatic stress varies widely. Compensatory cardiovascular responses to orthostatic stressors such as head-up tilt, +Gz acceleration, and lower body negative pressure (LBNP) have been identified. However, physiologic reactions associated with the capacity to withstand a presyncopal- limited orthostatic exposure requires additional clarification. The relationship between maximal oxygen uptake (‘VO₂ max) and presyncopal-limited LBNP tolerance was examined in adult male subjects categorized into high (HAC) and low (LAC) aerobic capacity groups. In addition to similar (N

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26

Knowles, Ian David. "The role of 5-HTâ†2 receptors in central cardiovascular regulation in anaesthetized rats." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313783.

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27

Newby, David Ernest. "Studies into the role of endogenous angiotensin II in the regulation of peripheral vascular tone in health and disease." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299605.

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28

Zhao, Jiexin. "Investigating the CaMKKβ signalling pathway and its role in the regulation of blood pressure". Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/42781.

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Calcium/Calmodulin dependent protein kinase kinase beta (CaMKKβ) is a serine/threonine kinase involved in the Calcium/Calmodulin dependent protein kinase (CaMK) cascade. In 2005, CaMKKβ was shown to phosphorylate and activate AMP-activated protein kinase (AMPK), a master regulator of metabolism. Activation of AMPK has previously been reported to inhibit vascular smooth muscle myosin light chain (MLC) phosphorylation. The phosphorylation state of MLC in smooth muscle is known to directly control the contractility of blood vessels and the maintenance of blood pressure. This thesis describes the

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29

Dhindaw, Seema. "Characterization of a 793 Kilobase Segment of the Rat Genome in Blood Pressure Regulation." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1188911291.

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30

Pandey, Varunkumar Girijaprasad. "The Effect of Glucocorticoids on Regulation of the Human Angiotensinogen Gene and Blood Pressure." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1378647891.

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31

Williams, DeWayne P. "Ethnicity, Sex, and Vagal Activity: Differences in Hemodynamics Underlying Long-Term Blood Pressure Regulation." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500640025670825.

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32

Crandall, Craig G. (Craig Gerald). "Alterations in Human Baroreceptor Reflex Regulation of Blood Pressure Following 15 Days of Simulated Microgravity Exposure." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc278142/.

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Prolonged exposure to microgravity is known to invoke physiological changes which predispose individuals to orthostatic intolerance upon readaptation to the earth's gravitational field. Attenuated baroreflex responsiveness has been implicated in contributing to this inability to withstand orthostatic stress. To test this hypothesis, eight individuals were exposed to 15 days of simulated microgravity exposure using the 6° head-down bed rest model. Prior to, and after the simulated microgravity exposure, the following were assessed: a) aortic baroreflex function; b) carotid baroreflex function;

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33

Hudson, Donna Louise. "The Effects of Lower Body Negative Pressure on the Cardiovascular System: The Relationships of Gender and Aerobic Fitness." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc935602/.

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Sixteen males and sixteen females were recruited for this study; eight of each gender were aerobically trained athletes; the remaining eight were untrained control subjects. Each subject performed a maximal exercise stress test for aerobic capacity (VO2max). On a separate day the blood volume and the cardiovascular responses to progressive (0 to -50 torr) lower body negative pressure (LBNP) were determined. The female subjects were observed to be significantly more tolerant of the LBNP than the male subjects. No differences between groups were observed in changes in leg volume, cardiac index,

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34

Pollock, Brandon S. "Determining the influence of limb and gender on blood pressure regulation and functional sympatholysis during the application of negative pressure." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1445348894.

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35

D'Antono, Bianca. "The relationship between risk for hypertension and the regulation of blood pressure and pain sensitivity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0024/NQ50139.pdf.

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36

Vasudevan, Harish. "Testosterone-dependent vascular arachidonic acid metabolism in the regulation of insulin resistance and blood pressure." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/8704.

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Insulin resistance (IR) and elevated blood pressure (BP) are two key features of the metabolic syndrome, which play an important role in the development of secondary cardiovascular complications. Feeding rats a diet rich in sugars such as fructose induces IR followed by vascular abnormalities and elevation in BP. Insulin resistance impairs the fine balance between endothelial vasoconstrictors and vasorelaxants, which results in endothelial dysfunction (ED). Differences in sex hormones play an important role in the development of insulin resistance and blood pressure as testosterone is essentia

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37

Nakao, Kazuhiro. "ENDOTHELIUM-DERIVED C-TYPE NATRIURETIC PEPTIDE CONTRIBUTES TO BLOOD PRESSURE REGULATION BY MAINTAINING ENDOTHELIAL INTEGRITY." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225500.

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38

Ramsey, Michael W., Bradley J. Behnke, Rhonda D. Prisby, and Michael D. Delp. "Effects of Aging on Adipose Resistance Artery Vasoconstriction: Possible Implications for Orthostatic Blood Pressure Regulation." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/4135.

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The purpose of this investigation was to determine mean arterial pressure (MAP) and regional vascular conductance responses in young and aged Fisher-344 rats during orthostatic stress, i.e., 70° head-up tilt (HUT). Both groups demonstrated directionally different changes in MAP during HUT (young, 7% increase; aged, 7% decrease). Vascular conductance during HUT in young rats decreased in most tissues but largely remained unchanged in the aged animals. Based on the higher vascular conductance of white adipose tissue from aged rats during HUT, resistance arteries from white visceral fat were isol

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39

Bizzotto, Dario. "Involvement of TGF-?1 in Multimerin-2, but not Emilin-2 regulation of blood pressure." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3427325.

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Emilins are a family of extracellular matrix (ECM) glycoproteins characterized by a cysteine-rich N-terminal EMI domain. The family comprises four members in mammals: Emilin-1, Emilin-2, Multimerin-1 and Multimerin-2. The prototype of this family is Emilin-1, a protein widely distributed in interstitial connective tissue in association with elastic fibers and strongly expressed in the mouse cardiovascular system during development and in the adult. Emilin1 knockout animals display increased blood pressure, increased peripheral vascular resistance, and reduced size of arterial tunica media. The

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40

Azizi, Newsha. "Blood pressure regulation in ANP-knockout mice, the role of angiotensin II-stimulated vasopressin release mechanism." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0027/MQ40861.pdf.

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41

Debiec, Radoslaw Marek. "Analysis of genetic variation within urotensin-II system in regulation of blood pressure and renal function." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28017.

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Elevated blood pressure (BP) and reduced glomerular filtration rate (GFR) are risk factors for cardiovascular disease. BP and GFR are influenced by heritable factors. Only small proportion of this heritability has been explained so far. This project aimed to identify genetic loci contributing to population variation in BP or GFR through application of candidate gene and large scale genotyping approaches. The candidate gene approach utilised tagging single nucleotide polymorphisms (SNP) in genes of the urotensin-II (U-II) pathway in a sample of white European subjects (3 family collections and

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42

Adlam, David. "The role of nitric oxide - redox signalling in blood pressure and heart rate regulation in vivo." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437387.

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43

Ehret, Georg B., Teresa Ferreira, Daniel I. Chasman, et al. "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/623255.

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To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular to

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44

Ibeawuchi, Stella-Rita C. "Regulation of vascular function: roles for Cullin-3 and RhoBTB1 In Pparγ-mediated blood pressure control". Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1637.

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Hypertension and type II diabetes are key components of metabolic syndrome affecting one third of US population. Insulin-sensitizing thiazolidinediones (TZDs) are high affinity synthetic ligands for Peroxisome Proliferator-Activated Receptor gamma (PPARG), a nuclear receptor and ligand-activated transcription factor. Clinical data show that TZDs are cardioprotective and lower blood pressure even with increased water and salt retention, suggesting a direct role for PPARG in blood pressure regulation. Human subjects with PPARG mutations exhibit severe early onset hypertension, insulin resistance

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45

Grimaldi, Daniela <1974&gt. "Narcolepsy: state-dependent autonomic regulation and circadian control of blood pressure, heart rate, body core temperature." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1706/1/grimaldi_daniela_tesi.pdf.

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46

Grimaldi, Daniela <1974&gt. "Narcolepsy: state-dependent autonomic regulation and circadian control of blood pressure, heart rate, body core temperature." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1706/.

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47

Turnbull, Fiona. "Effects of different blood pressure-lowering regimens on major cardiovascular events in major patient subgroups." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28142.

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Background Cardiovascular disease is a leading cause of mortality and morbidity worldwide. Blood pressure is the single, most important risk factor for cardiovascular disease; nearly two-thirds of all strokes and approximately half of all ischaemic heart disease events are attributable to non-optimal blood pressure. The evidence from individual randomised trials of blood pressure lowering regimens suggests that that protection from major cardiovascular events can be achieved by lowering blood pressure, even among those with so-called ‘normal’ blood pressures. However, many trials are no

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48

Van, Berge-Landry Helene Margaret-Rose. "Ethnic differences in diurnal blood pressure variation and regulation the effects of catecholamines, cortisol, and IL-6 /." Diss., Online access via UMI:, 2008.

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49

Crossley, II Dane Alan. "The Role of Pulmocutaneous Baroreceptors in the Control of Lymphatic Heart Rate in the Toad Bufo Marinus." PDXScholar, 1995. https://pdxscholar.library.pdx.edu/open_access_etds/4892.

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The present study documents that baroreceptors located in the pulmocutaneous artery (PCA) are key components in control of lymph heart rate in amphibians. A negative feedback control loop exists between arterial pressure and lymphatic heart rate. The recurrent laryngeal nerve (rLN), which innervates the PCA baroreceptors, transmits information on arterial pressure to integration centers in the central nervous system. Lymphatic heart rate (LHR) is reduced as a result of increases in arterial pressure. This loop was determined using three experimental protocols. First, the correlation between LH

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50

Smith, Michael Lamar 1957. "Fitness-Related Alterations in Blood Pressure Control: The Role of the Autonomic Nervous System." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331614/.

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Baroreflex function and cardiovascular responses to lower body negative pressure during selective autonomic blockade were evaluated in endurance exercise trained (ET) and untrained (UT) men. Baroreflex function was evaluated using a progressive intravenous infusion of phenylephrine HCL (PE) to a maximum of 0.12 mg/min. Heart rate, arterial blood pressure, cardiac output and forearm blood flow were measured at each infusion rate of PE. The reduction in forearm blood flow and concomitant rise in forearm vascular resistance was the same for each subject group. However, the heart rate decreases pe

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