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Journal articles on the topic 'Blood Progenitor Cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Scott, MA, JF Apperley, HK Jestice, DM Bloxham, RE Marcus, and MY Gordon. "Plastic-adherent progenitor cells in mobilized peripheral blood progenitor cell collections." Blood 86, no. 12 (1995): 4468–73. http://dx.doi.org/10.1182/blood.v86.12.4468.bloodjournal86124468.

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The use of peripheral blood progenitor cells (PBPC) to reconstitute hematopoiesis after high-dose chemoradiotherapy is now commonplace in the treatment of malignancies. Attempts to characterize these cells have concentrated primarily on their phenotype and their content of clonogenic colony-forming cells (CFC). We have used a plastic-adherent delta (P delta) assay system to evaluate the quantity and quality of more primitive cells in addition to the conventional measurements of CFC and CD34-positive cells. The leukapheresis products from 20 patients mobilized using cyclophosphamide (Cy) and gr

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2

Ghinassi, Barbara, Massimo Sanchez, Fabrizio Martelli, et al. "The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor." Blood 109, no. 4 (2006): 1460–71. http://dx.doi.org/10.1182/blood-2006-07-030726.

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Abstract Recent evidence suggests that mutations in the Gata1 gene may alter the proliferation/differentiation potential of hemopoietic progenitors. By single-cell cloning and sequential replating experiments of prospectively isolated progenitor cells, we demonstrate here that the hypomorphic Gata1low mutation increases the proliferation potential of a unique class of progenitor cells, similar in phenotype to adult common erythroid/megakaryocytic progenitors (MEPs), but with the “unique” capacity to generate erythroblasts, megakaryocytes, and mast cells in vitro. Conversely, progenitor cells p

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3

Buza-Vidas, Natalija, Petter Woll, Anne Hultquist, et al. "FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells." Blood 118, no. 6 (2011): 1544–48. http://dx.doi.org/10.1182/blood-2010-10-316232.

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Abstract Lymphoid-primed multipotent progenitors with down-regulated megakaryocyte-erythroid (MkE) potential are restricted to cells with high levels of cell-surface FLT3 expression, whereas HSCs and MkE progenitors lack detectable cell-surface FLT3. These findings are compatible with FLT3 cell-surface expression not being detectable in the fully multipotent stem/progenitor cell compartment in mice. If so, this process could be distinct from human hematopoiesis, in which FLT3 already is expressed in multipotent stem/progenitor cells. The expression pattern of Flt3 (mRNA) and FLT3 (protein) in

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4

Xiao, Yanling, Astrid G. S. van Halteren, Xin Lei, et al. "Bone marrow–derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis." Blood 136, no. 19 (2020): 2188–99. http://dx.doi.org/10.1182/blood.2020005209.

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Abstract Langerhans cell histiocytosis (LCH) is a myeloid neoplasia, driven by sporadic activating mutations in the MAPK pathway. The misguided myeloid dendritic cell (DC) model proposes that high-risk, multisystem, risk-organ–positive (MS-RO+) LCH results from driver mutation in a bone marrow (BM)-resident multipotent hematopoietic progenitor, while low-risk, MS-RO− and single-system LCH would result from driver mutation in a circulating or tissue-resident, DC-committed precursor. We have examined the CD34+c-Kit+Flt3+ myeloid progenitor population as potential mutation carrier in all LCH dise

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Heath, Victoria, Hyung Chan Suh, Matthew Holman та ін. "C/EBPα deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo". Blood 104, № 6 (2004): 1639–47. http://dx.doi.org/10.1182/blood-2003-11-3963.

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Abstract CCAAT enhancer binding protein-α (C/EBPα) inhibits proliferation in multiple cell types; therefore, we evaluated whether C/EBPα-deficient hematopoietic progenitor cells (HPCs) have an increased proliferative potential in vitro and in vivo. In this study we demonstrate that C/EBPα-/- fetal liver (FL) progenitors are hyperproliferative, show decreased differentiation potential, and show increased self-renewal capacity in response to hematopoietic growth factors (HGFs). There are fewer committed bipotential progenitors in C/EBPα-/- FL, whereas multipotential progenitors are unaffected. H

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6

Golan, Karin, Yaron Vagima, Aya Ludin, et al. "S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release." Blood 119, no. 11 (2012): 2478–88. http://dx.doi.org/10.1182/blood-2011-06-358614.

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Abstract The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (S1P) receptors by FTY720 as well as disruption of S1P gradient toward the blood, reduced steady state egress of immature progenitors and primitive Sca-1+/c-Kit+/Lin− (SKL) cells via inhibition of SDF-1 release. Administration of AMD3100 or G-CSF to mice with deficiencies in either S1P production or its receptor S1P1, or pretreated with FTY720, also resulted in reduced stem and progenitor cell mobilization.

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7

Sommerkamp, Pia, Mari Carmen Romero-Mulero, Andreas Narr, et al. "Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells." Blood 137, no. 23 (2021): 3218–24. http://dx.doi.org/10.1182/blood.2020007876.

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Abstract Hematopoietic stem cells (HSCs) and distinct multipotent progenitor (MPP) populations (MPP1-4) contained within the Lin−Sca-1+c-Kit+ (LSK) compartment have previously been identified using diverse surface-marker panels. Here, we phenotypically define and functionally characterize MPP5 (LSK CD34+CD135−CD48−CD150−). Upon transplantation, MPP5 supports initial emergency myelopoiesis followed by stable contribution to the lymphoid lineage. MPP5, capable of generating MPP1-4 but not HSCs, represents a dynamic and versatile component of the MPP network. To characterize all hematopoietic ste

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8

Stachura, David L., Ondrej Svoboda, Ryan P. Lau, et al. "Clonal analysis of hematopoietic progenitor cells in the zebrafish." Blood 118, no. 5 (2011): 1274–82. http://dx.doi.org/10.1182/blood-2011-01-331199.

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Abstract Identification of hematopoietic progenitor cells in the zebrafish (Danio rerio) has been hindered by a lack of functional assays to gauge proliferative potential and differentiation capacity. To investigate the nature of myeloerythroid progenitor cells, we developed clonal methylcellulose assays by using recombinant zebrafish erythropoietin and granulocyte colony-stimulating factor. From adult whole kidney marrow, erythropoietin was required to support erythroid colony formation, and granulocyte colony-stimulating factor was required to support the formation of colonies containing neu

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9

Davidoff, Michail S., Ralf Middendorff, Grigori Enikolopov, Dieter Riethmacher, Adolf F. Holstein, and Dieter Müller. "Progenitor cells of the testosterone-producing Leydig cells revealed." Journal of Cell Biology 167, no. 5 (2004): 935–44. http://dx.doi.org/10.1083/jcb.200409107.

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The cells responsible for production of the male sex hormone testosterone, the Leydig cells of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during ontogeny and regeneration processes is still a matter of debate. Here, we show that cells of testicular blood vessels, namely vascular smooth muscle cells and pericytes, are the progenitors of Leydig cells. Resembling stem cells of the nervous system, the Leydig cell progenitors are characterized by the expression of nestin. Using an in vivo model to induce and monitor the synchronized generation of a complete

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10

Scheding, S., JE Media, MA KuKuruga, and A. Nakeff. "In situ radiation sensitivity of recombinant human granulocyte colony- stimulating factor-recruited murine circulating blood and bone marrow progenitors (colony-forming unit [CFU]-granulocyte-macrophage and CFU- megakaryocyte): evidence for possible biologic differences between mobilized blood and bone marrow." Blood 88, no. 2 (1996): 472–78. http://dx.doi.org/10.1182/blood.v88.2.472.bloodjournal882472.

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Increasing evidence especially stemming from peripheral blood progenitor transplantation studies points to a possible biologic difference between mobilized blood and bone marrow progenitor cells. The objective of this study was to compare the in situ radiation sensitivity of recombinant human granulocyte colony-stimulating factor (rhG-CSF)-recruited circulating granulopoietic (blood colony-forming unit-granulocyte-macrophage [CFU-GM(blood)]) and megakaryocytopoietic (blood CFU-megakaryocyte [CFU-Meg(blood)]) progenitors, with the nonmobilized fraction remaining in the bone marrow (CFU-GM(femur

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11

Qian, Hong, Karl Tryggvason, Sten Eirik Jacobsen та Marja Ekblom. "Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins". Blood 107, № 9 (2006): 3503–10. http://dx.doi.org/10.1182/blood-2005-10-3932.

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The laminin receptor integrin α6 chain is ubiquitously expressed in human and mouse hematopoietic stem and progenitor cells. We have studied its role for homing of stem and progenitor cells to mouse hematopoietic tissues in vivo. A function-blocking anti–integrin α6 antibody significantly reduced progenitor cell homing to bone marrow (BM) of lethally irradiated mice, with a corresponding retention of progenitors in blood. Remarkably, the anti–integrin α6 antibody profoundly inhibited BM homing of long-term multilineage engrafting stem cells, studied by competitive repopulation assay and analys

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Bakken, Anne. "Cryopreserving Human Peripheral Blood Progenitor Cells." Current Stem Cell Research & Therapy 1, no. 1 (2006): 47–54. http://dx.doi.org/10.2174/157488806775269179.

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13

Rohde, Eva, Christina Malischnik, Daniela Thaler, et al. "Blood Monocytes Mimic Endothelial Progenitor Cells." Stem Cells 24, no. 2 (2006): 357–67. http://dx.doi.org/10.1634/stemcells.2005-0072.

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14

Brugger, W., S. Scheding, W. Vogel, and L. Kanz. "Purging of peripheral blood progenitor cells." Annals of Oncology 7 (1996): 11–13. http://dx.doi.org/10.1093/annonc/7.suppl_2.11.

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15

Carlo-Stella, C., and V. Rizzoli. "In Vitro Manipulation of Peripheral Blood Progenitor Cell Collections." International Journal of Artificial Organs 21, no. 6_suppl (1998): 1–10. http://dx.doi.org/10.1177/039139889802106s01.

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Mobilized peripheral blood progenitor cells (PBPC) are increasingly used to reconstitute hematopoiesis in patients undergoing high-dose chemoradiotherapy. PBPC collections comprise a heterogeneous population containing both committed progenitors and pluripotent stem cells and can be harvested (i) in steady state, (ii) after chemotherapeutic conditioning, (iii) growth factor priming, or (iv) both. The use of PBPC has opened new therapeutic perspectives mainly related to the availability of large amounts of mobilized hematopoietic stem and progenitor cells. Extensive manipulation of the grafts,

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16

Awong, Génève, Elaine Herer, Charles D. Surh, John E. Dick, Ross N. La Motte-Mohs, and Juan Carlos Zúñiga-Pflücker. "Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells." Blood 114, no. 5 (2009): 972–82. http://dx.doi.org/10.1182/blood-2008-10-187013.

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T-cell development follows a defined set of stage-specific differentiation steps. However, molecular and cellular events occurring at early stages of human T-cell development remain to be fully elucidated. To address this, human umbilical cord blood (UCB) hematopoietic stem cells (HSCs) were induced to differentiate to the T lineage in OP9-DL1 cocultures. A developmental program involving a sequential and temporally discrete expression of key differentiation markers was revealed. Quantitative clonal analyses demonstrated that CD34+CD38− and CD34+CD38lo subsets of UCB contain a similarly high T

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17

Terskikh, Alexey V., Toshihiro Miyamoto, Cynthia Chang, Luda Diatchenko, and Irving L. Weissman. "Gene expression analysis of purified hematopoietic stem cells and committed progenitors." Blood 102, no. 1 (2003): 94–101. http://dx.doi.org/10.1182/blood-2002-08-2509.

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Abstract Lifelong self-renewal is a unique property of somatic stem cells. Recently, several primitive multipotent yet committed (non—self-renewing) hematopoietic progenitor populations were identified in mouse bone marrow. We have characterized the expression of 1200 selected mouse genes using the Atlas cDNA array in highly purified hematopoietic stem cells (HSCs) and 6 closely related progenitor populations: common myeloid progenitors (CMPs), granulocyte-macrophage progenitors (GMPs), megakaryocyte-erythrocyte progenitors (MEPs), common lymphoid progenitors (CLPs), and pro-T and pro-B cells.

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18

Metcalf, Donald, Marina R. Carpinelli, Craig Hyland, et al. "Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene." Blood 105, no. 9 (2005): 3480–87. http://dx.doi.org/10.1182/blood-2004-12-4806.

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AbstractMpl -/- mice bearing the Plt3 or Plt4 mutations in the c-Myb gene exhibit thrombopoietin (TPO)–independent supraphysiological platelet production accompanied by excessive megakaryocytopoiesis and defective erythroid and lymphoid cell production. To better define the cellular basis for the thrombocytosis in these mice, we analyzed the production and characteristics of megakaryocytes and their progenitors. Consistent with thrombocytosis arising from hyperactive production, the high platelet counts in mice carrying the c-MybPlt4 allele were not accompanied by any significant alteration in

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Di Giandomenico, Silvana, Pouneh Kermani, Nicole Mollé та ін. "Megakaryocyte TGFβ1 partitions erythropoiesis into immature progenitor/stem cells and maturing precursors". Blood 136, № 9 (2020): 1044–54. http://dx.doi.org/10.1182/blood.2019003276.

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Abstract Erythropoietin (EPO) provides the major survival signal to maturing erythroid precursors (EPs) and is essential for terminal erythropoiesis. Nonetheless, progenitor cells can irreversibly commit to an erythroid fate well before EPO acts, risking inefficiency if these progenitors are unneeded to maintain red blood cell (RBC) counts. We identified a new modular organization of erythropoiesis and, for the first time, demonstrate that the pre-EPO module is coupled to late EPO-dependent erythropoiesis by megakaryocyte (Mk) signals. Disrupting megakaryocytic transforming growth factor β1 (T

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Li, Yan, Shi Chen, Jin Yuan, et al. "Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg−/− mice in vivo." Blood 113, no. 10 (2009): 2342–51. http://dx.doi.org/10.1182/blood-2008-07-168138.

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AbstractFanconi anemia (FA) is a heterogeneous genetic disorder characterized by bone marrow failure and complex congenital anomalies. Although mutations in FA genes result in a characteristic phenotype in the hematopoietic stem/progenitor cells (HSPCs), little is known about the consequences of a nonfunctional FA pathway in other stem/progenitor cell compartments. Given the intense functional interactions between HSPCs and the mesenchymalmicroenvironment, we investigated the FA pathway on the cellular functions of murine mesenchymal stem/progenitor cells (MSPCs) and their interactions with HS

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21

Bhatia, Ravi, Melissa Holtz, Ning Niu, et al. "Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment." Blood 101, no. 12 (2003): 4701–7. http://dx.doi.org/10.1182/blood-2002-09-2780.

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AbstractThe BCR/ABL tyrosine kinase inhibitor imatinib mesylate (Gleevec, STI571; Novartis, Basel, Switzerland) has shown remarkable efficacy in the treatment of chronic myelogenous leukemia (CML), with a high proportion of patients achieving complete cytogenetic responses (CCRs). However, it is not clear whether remissions will be durable and whether imatinib mesylate can eliminate the malignant primitive progenitors in which the disease arises. We investigated whether residual BCR/ABL+ hematopoietic progenitors were present in patients who achieved CCRs with imatinib mesylate treatment. CD34

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Porat, Yael, Valentin Fulga, Danny Belkin, et al. "Adult Human Blood Leukocytes as an Efficient Source for Tissue-Committed Neural Progenitors." Blood 106, no. 11 (2005): 1686. http://dx.doi.org/10.1182/blood.v106.11.1686.1686.

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Abstract In the last few years, significant progress has been made in the isolation and characterization of bone marrow stem cell populations and their potential to differentiate into a variety of cellular lineages. We hypothesized that peripheral blood can also be used as a source for precursor cells that can become committed progenitors for a variety of tissues. We report here the generation and characterization in vitro of neural progenitor cells from a newly discovered blood-derived multipotent cell population, named synergetic cell population (SCP). Human blood samples were obtained from

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Horman, Shane R., Chinavenmeni S. Velu, Aditya Chaubey, et al. "Gfi1 integrates progenitor versus granulocytic transcriptional programming." Blood 113, no. 22 (2009): 5466–75. http://dx.doi.org/10.1182/blood-2008-09-179747.

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AbstractIn patients with severe congenital neutropenia (SCN) and mice with growth factor independent-1 (Gfi1) loss of function, arrested myeloid progenitors accumulate, whereas terminal granulopoiesis is blocked. One might assume that Gfi-null progenitors accumulate because they lack the ability to differentiate. Instead, our data indicate that Gfi1 loss of function deregulates 2 separable transcriptional programs, one of which controls the accumulation and lineage specification of myeloid progenitors, but not terminal granulopoiesis. We demonstrate that Gfi1 directly represses HoxA9, Pbx1, an

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Tan, Jonathan K. H., Pravin Periasamy, and Helen C. O'Neill. "Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells." Blood 115, no. 18 (2010): 3678–85. http://dx.doi.org/10.1182/blood-2009-06-227108.

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Abstract Hematopoietic cell lineages are best described in terms of distinct progenitors with limited differentiative capacity. To distinguish cell lineages, it is necessary to define progenitors and induce their differentiation in vitro. We previously reported in vitro development of immature dendritic-like cells (DCs) in long-term cultures (LTCs) of murine spleen, and in cocultures of spleen or bone marrow (BM) over splenic endothelial cell lines derived from LTCs. Cells produced are phenotypically distinct CD11bhiCD11cloCD8−MHC-II− cells, tentatively named L-DCs. Here we delineate L-DC prog

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Wang, Alice, and S. Ananth Karumanchi. "Relaxin' with endothelial progenitor cells." Blood 119, no. 2 (2012): 326–27. http://dx.doi.org/10.1182/blood-2011-11-389494.

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Segal and colleagues in this issue of Blood report their findings about an additional new function for the hormone relaxin: turning on bone marrow–derived endothelial progenitor cells to sites of neoangiogenesis.1

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Bahlmann, Ferdinand H., Kirsten de Groot, Jens-Michael Spandau, et al. "Erythropoietin regulates endothelial progenitor cells." Blood 103, no. 3 (2004): 921–26. http://dx.doi.org/10.1182/blood-2003-04-1284.

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AbstractCirculating bone marrow–derived endothelial progenitor cells (EPCs) promote vascular reparative processes and neoangiogenesis, and their number in peripheral blood correlates with endothelial function and cardiovascular risk. We tested the hypothesis that the cytokine erythropoietin (EPO) stimulates EPCs in humans. We studied 11 patients with renal anemia and 4 healthy subjects who received standard doses of recombinant human EPO (rhEPO). Treatment with rhEPO caused a significant mobilization of CD34+/CD45+ circulating progenitor cells in peripheral blood (measured by flow cytometry),

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Soukup, Alexandra, Kirby D. Johnson, Daniel J. Conn, et al. "GATA2-Dependent Developmental and Regenerative Networks." Blood 134, Supplement_1 (2019): 1182. http://dx.doi.org/10.1182/blood-2019-126875.

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Coding and regulatory human GATA2 mutations that deregulate protein expression and/or function cause immunodeficiency that often progresses to MDS/AML (McReynolds et al., 2018). In the mouse, decreased GATA2 expression impairs hematopoietic stem/progenitor cell (HSPC) genesis and function (de Pater et al., 2013; Gao et al., 2013; Tsai et al., 1994). While prior studies demonstrated Gata2 +9.5 and -77 enhancers are essential for HSC emergence (+9.5) and/or progenitor cell fate (+9.5 and -77) (Johnson et al., 2012; Johnson et al., 2015; Mehta et al., 2017) and hematopoietic regeneration (+9.5) (

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Nixon, Christopher C., Dimitrios N. Vatakis, Scott N. Reichelderfer, et al. "HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice." Blood 122, no. 13 (2013): 2195–204. http://dx.doi.org/10.1182/blood-2013-04-496950.

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Key PointsSome CD34+CD38+ intermediate hematopoietic progenitor cells express HIV-1 entry receptors and are susceptible to direct infection by HIV. Blood progenitors from HIV-exposed, humanized BLT mice show impaired hematopoietic potential and give rise to progeny that harbor provirus.

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Chen, Aaron Yun, Elizabeth Yan Zhang, Wuxiang Guan, et al. "The small 11kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells." Blood 115, no. 5 (2010): 1070–80. http://dx.doi.org/10.1182/blood-2009-04-215756.

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AbstractHuman parvovirus B19 (B19V) infection shows a strong erythroid tropism and drastically destroys erythroid progenitor cells, thus leading to most of the disease outcomes associated with B19V infection. In this study, we systematically examined the 3 B19V nonstructural proteins, 7.5kDa, 11kDa, and NS1, for their function in inducing apoptosis in transfection of primary ex vivo–expanded erythroid progenitor cells, in comparison with apoptosis induced during B19V infection. Our results show that 11kDa is a more significant inducer of apoptosis than NS1, whereas 7.5kDa does not induce apopt

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Singh, Pratibha, Jonathan Hoggatt, Peirong Hu, et al. "Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells." Blood 119, no. 7 (2012): 1671–82. http://dx.doi.org/10.1182/blood-2011-03-342428.

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Abstract Dendritic cell (DC) homeostasis, like all mature blood cells, is maintained via hierarchal generation from hematopoietic precursors; however, little is known about the regulatory mechanisms governing DC generation. Here, we show that prostaglandin E2 (PGE2) is required for optimal Flt3 ligand–mediated DC development and regulates expression of the Flt3 receptor on DC-committed progenitor cells. Inhibition of PGE2 biosynthesis reduces Flt3-mediated activation of STAT3 and expression of the antiapoptotic protein survivin, resulting in increased apoptosis of DC-committed progenitor cells

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Zandi, Sasan, Faiyaz Notta, John E. Dick, et al. "The Human Blood Hierarchy Is Shaped By Distinct Progenitor Lineages Across Development." Blood 126, no. 23 (2015): 2360. http://dx.doi.org/10.1182/blood.v126.23.2360.2360.

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Abstract Background: The hematopoietic roadmap is a compilation of the various lineage differentiation routes that a stem cell takes to make blood. On several occasions over the last six decades, the murine roadmap has been reconceived due to new information overturning old dogmas. The human roadmap, which describes the extraordinary throughput of more than three hundred billion cells daily has changed little, with the classical model of hematopoiesis still prevailing. In this model, blood differentiation initiated at the level of stem cells must pass through a series of increasingly lineage-r

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Gehling, Ursula M., Süleyman Ergün, Udo Schumacher, et al. "In vitro differentiation of endothelial cells from AC133-positive progenitor cells." Blood 95, no. 10 (2000): 3106–12. http://dx.doi.org/10.1182/blood.v95.10.3106.

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Abstract Recent findings support the hypothesis that the CD34+-cell population in bone marrow and peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this study, we report that human AC133+ cells from granulocyte colony-stimulating factor–mobilized peripheral blood have the capacity to differentiate into endothelial cells (ECs). When cultured in the presence of vascular endothelial growth factor (VEGF) and the novel cytokine stem cell growth factor (SCGF), AC133+ progenitors generate both adherent and proliferating nonadherent cells. Phenotypic analysis of the

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Gehling, Ursula M., Süleyman Ergün, Udo Schumacher, et al. "In vitro differentiation of endothelial cells from AC133-positive progenitor cells." Blood 95, no. 10 (2000): 3106–12. http://dx.doi.org/10.1182/blood.v95.10.3106.010k08_3106_3112.

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Recent findings support the hypothesis that the CD34+-cell population in bone marrow and peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this study, we report that human AC133+ cells from granulocyte colony-stimulating factor–mobilized peripheral blood have the capacity to differentiate into endothelial cells (ECs). When cultured in the presence of vascular endothelial growth factor (VEGF) and the novel cytokine stem cell growth factor (SCGF), AC133+ progenitors generate both adherent and proliferating nonadherent cells. Phenotypic analysis of the cells wi

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Kundu, Mondira, Amy Chen, Stacie Anderson, et al. "Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11." Blood 100, no. 7 (2002): 2449–56. http://dx.doi.org/10.1182/blood-2002-04-1064.

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Core-binding factor β (CBFβ) and CBFα2 form a heterodimeric transcription factor that plays an important role in hematopoiesis. The genes encoding either CBFβ or CBFα2 are involved in chromosomal rearrangements in more than 30% of cases of acute myeloid leukemia (AML), suggesting that CBFβ and CBFα2 play important roles in leukemogenesis. Inv(16)(p13;q22) is found in almost all cases of AML M4Eo and results in the fusion ofCBFB with MYH11, the gene encoding smooth muscle myosin heavy chain. Mouse embryos heterozygous for aCbfb-MYH11 knock-in gene lack definitive hematopoiesis, a phenotype shar

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Bilko, N. M., I. S. Dyagil, I. S. Russu, and D. I. Bilko. "CIRCULATING HEMATOPOIETIC PROGENITOR CELLS IN PATIENTS AFFECTED BY CHORNOBYL ACCIDENT." Experimental Oncology 38, no. 4 (2016): 242–44. http://dx.doi.org/10.31768/2312-8852.2016.38(4):242-244.

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High radiation sensitivity of stem cells and their ability to accumulate sublethal radiation damage provides the basis for investigation of hematopoietic progenitors using in vivo culture methodology. Unique samples of peripheral blood and bone marrow were derived from the patients affected by Chornobyl accident during liquidation campaign. Aim: To investigate functional activity of circulating hematopoietic progenitor cells from peripheral blood and bone marrow of cleanup workers in early and remote periods after the accident at Chornobyl nuclear power plant (CNPP). Materials and Methods: The

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Stoll, Brian R., Cristiano Migliorini, Ananth Kadambi, Lance L. Munn, and Rakesh K. Jain. "A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy." Blood 102, no. 7 (2003): 2555–61. http://dx.doi.org/10.1182/blood-2003-02-0365.

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Abstract The traditional view of angiogenesis emphasizes proliferation and migration of vessel wall-associated endothelial cells. However, circulating endothelial progenitor cells have recently been shown to contribute to tumor angiogenesis. Here we quantify the relative contributions of endothelial and endothelial progenitor cells to angiogenesis using a mathematical model. The model predicts that during the early stages of tumor growth, endothelial progenitors have a significant impact on tumor growth and angiogenesis, mediated primarily by their localization in the tumor, not by their proli

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Scanlon, Vanessa M., Maria Kochugaeva, Juliana Xavier-Ferrucio, et al. "Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict Potential." Blood 134, Supplement_1 (2019): 1190. http://dx.doi.org/10.1182/blood-2019-131204.

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The molecular mechanisms underlying lineage commitment of stem and progenitor cells have implications for deriving specific cell types in vitro for regenerative medicine purposes and elucidating the aberrant pathways responsible for pathological conditions. We investigated Megakaryocytic-Erythroid Progenitors (MEP) commitment to the megakaryocytic (Mk) and erythroid (E) lineages as a model of cell fate decisions. Colony forming unit (CFU) assays are used to test the functional output, or lineage potential, of progenitor cell populations. As single progenitor cells proliferate, their progeny re

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Yoder, Mervin C. "Endothelial stem and progenitor cells (stem cells): (2017 Grover Conference Series)." Pulmonary Circulation 8, no. 1 (2017): 204589321774395. http://dx.doi.org/10.1177/2045893217743950.

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The capacity of existing blood vessels to give rise to new blood vessels via endothelial cell sprouting is called angiogenesis and is a well-studied biologic process. In contrast, little is known about the mechanisms for endothelial cell replacement or regeneration within established blood vessels. Since clear definitions exist for identifying cells with stem and progenitor cell properties in many tissues and organs of the body, several groups have begun to accumulate evidence that endothelial stem and progenitor cells exist within the endothelial intima of existing blood vessels. This paper w

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Boles, Nathan C., Kuanyin K. Lin, Georgi L. Lukov, Teresa V. Bowman, Megan T. Baldridge, and Margaret A. Goodell. "CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation." Blood 118, no. 1 (2011): 80–87. http://dx.doi.org/10.1182/blood-2010-12-322339.

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Abstract The proliferation and differentiation of adult stem cells is balanced to ensure adequate generation of differentiated cells, stem cell homeostasis, and guard against malignant transformation. CD48 is broadly expressed on hematopoietic cells but excluded from quiescent long-term murine HSCs. Through its interactions with CD244 on progenitor cells, it influences HSC function by altering the BM cytokine milieu, particularly IFNγ. In CD48-null mice, the resultant misregulation of cytokine signaling produces a more quiescent HSC, a disproportionate number of short-term progenitors, and hyp

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Welner, Robert S., Deepak Bararia, Giovanni Amabile та ін. "C/EBPα is required for development of dendritic cell progenitors". Blood 121, № 20 (2013): 4073–81. http://dx.doi.org/10.1182/blood-2012-10-463448.

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Sommarin, Mikael, Parashar Dhapola, Linda Geironson Ulfsson, et al. "Immunophenotypic- and Molecular Analysis of Human Hematopoietic Stem and Progenitor Heterogeneity." Blood 134, Supplement_1 (2019): 3701. http://dx.doi.org/10.1182/blood-2019-126407.

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Hematopoietic stem cells (HSCs) have the capacity to differentiate into all hematopoietic lineages and at the same time self-renew to maintain the HSC pool. HSCs have been thoroughly investigated using immunophenotypic-, molecular- and functional-analysis resulting in the development of protocols for high-purity prospective isolation of human HSCs. However, within the current state-of-the-art HSC populations, 90% of the cells lack stem cell activity, confounding molecular analysis of HSC function. Thus, identification of novel immunophenotypic markers to delineate the HSC population would impr

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Wang, Chunlin, Chunhua Jiao, Heather D. Hanlon, Wei Zheng, Robert J. Tomanek, and Gina C. Schatteman. "Mechanical, cellular, and molecular factors interact to modulate circulating endothelial cell progenitors." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 5 (2004): H1985—H1993. http://dx.doi.org/10.1152/ajpheart.00431.2003.

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It appears that there are two classes of human circulating endothelial cell (EC) progenitors, CD34+and CD34–CD14+cells. Attention has focused on CD34+cells, yet CD34–CD14+monocytic cells are far more abundant and may represent the most common class of circulating EC progenitor. Little is known about molecular or physiological factors that regulate putative CD34–CD14+EC progenitor function, although factors secreted by other blood and cardiovascular cells to which they are exposed probably affect their behavior. Hypoxia and stretch are two important physiological stimuli known to trigger growth

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Ahmed, Tauseef, David Ciavarella, Perry Cook, and David Wuest. "Blood Progenitor Cells: Collection Techniques and Applications." Cancer Investigation 12, no. 4 (1994): 421–24. http://dx.doi.org/10.3109/07357909409038235.

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Colunga, Thomas, and Stephen Dalton. "Building Blood Vessels with Vascular Progenitor Cells." Trends in Molecular Medicine 24, no. 7 (2018): 630–41. http://dx.doi.org/10.1016/j.molmed.2018.05.002.

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Simper, David, Paul G. Stalboerger, Carmelo J. Panetta, Shaohua Wang, and Noel M. Caplice. "Smooth Muscle Progenitor Cells in Human Blood." Circulation 106, no. 10 (2002): 1199–204. http://dx.doi.org/10.1161/01.cir.0000031525.61826.a8.

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Pettengell, R. "Expanding the role of blood progenitor cells." Annals of Oncology 6, no. 8 (1995): 759–67. http://dx.doi.org/10.1093/oxfordjournals.annonc.a059313.

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Link, H., and L. Arseniev. "Allogeneic transplantation of peripheral blood progenitor cells." Annals of Oncology 7 (1996): 41–45. http://dx.doi.org/10.1093/annonc/7.suppl_2.41.

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BROXMEYER, HAL E., and CATHERINE E. CAROW. "Characterization of Cord Blood Stem/Progenitor Cells." Journal of Hematotherapy 2, no. 2 (1993): 197–99. http://dx.doi.org/10.1089/scd.1.1993.2.197.

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FIELDING, ADELE K., MICHAEL J. WATTS, and ANTHONY H. GOLDSTONE. "Peripheral Blood Progenitor Cells Versus Bone Marrow." Journal of Hematotherapy 3, no. 4 (1994): 299–304. http://dx.doi.org/10.1089/scd.1.1994.3.299.

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Chao, NelsonJ, GwynnD Long, RobertS Negrin, et al. "G-CSF and peripheral blood progenitor cells." Lancet 339, no. 8806 (1992): 1410–11. http://dx.doi.org/10.1016/0140-6736(92)91227-y.

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