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Relevant bibliographies by topics / Blood pumps

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Academic literature on the topic 'Blood pumps'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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Journal articles on the topic "Blood pumps"

1

CHEN, ZENGSHENG, ZHAOHUI YAO, LAILAI ZHU, and XIWEN ZHANG. "HEMOLYSIS ANALYSIS OF AXIAL BLOOD PUMPS WITH VARIOUS STRUCTURE IMPELLERS." Journal of Mechanics in Medicine and Biology 13, no. 04 (July 7, 2013): 1350054. http://dx.doi.org/10.1142/s0219519413500541.

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Low hemolysis is an important factor for axial blood pumps that has been used in patients with heart failure. The structure of impellers plays a key role in the hemolytic properties of axial blood pumps. Axial blood pumps with various structure impellers exhibit different hemolytic characteristic. In the present study, we aimed to investigate the type of impellers structures in axial blood pumps that contain the best low hemolytic properties. Also, it is expensive and time-consuming to validate the axial blood pump's hemolytic property by in vivo experiments. Therefore, in the present study, the numerical method was applied to analyze the hemolytic property in a blood pump. Specifically, the hemolysis of the pump was calculated by using a forward Euler approach based on the changes in shear stress and related exposure times along the particle trace lines. The different vane structures and rotational speed that affect hemolysis were analyzed and compared. The results showed that long–short alternant vanes exhibited the best hemolytic property which could be utilized in the optimization design of axial blood pumps.

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Akdis, M., and H. Reul. "Mechanical Blood Pumps for Cardiac Assistance." Applied Bionics and Biomechanics 2, no. 2 (2005): 73–80. http://dx.doi.org/10.1155/2005/409650.

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Cardiac assist devices are classified into the traditional engineering categories of displacement and rotary pumps. Clinical use and indications of the various pump categories are outlined and a detailed description of currently available systems is given. The first part deals with extracorporeal as well as implantable ventricular assist devices (VAD) of the displacement type and is followed by a section on current developments in the field of total artificial hearts (TAH). The second part covers the rotary pump category from cardiopulmonary bypass applications to implantable systems, including specific design aspects of radial, diagonal, and axial pumps.

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Köhne, Inge. "Review and reflections about pulsatile ventricular assist devices from history to future: concerning safety and low haemolysis—still needed." Journal of Artificial Organs 23, no. 4 (May 4, 2020): 303–14. http://dx.doi.org/10.1007/s10047-020-01170-3.

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AbstractSince the first use of a ventricular assist device in 1963 many extracorporeal and implantable pulsatile blood pumps have been developed. After the invention of continuous flow blood pumps the implantable pulsatile pumps are not available anymore. The new rotary pumps spend a better quality of life because many of the patients can go home. Nevertheless, the extracorporeal pulsatile pumps have some advantages. They are low-cost systems, produce less haemolysis and heart-recovery can be tested easily. Pump failure is easy to realize because the pumps can be observed visually. Pump exchange can be done easily without any chirurgic surgery. As volume displacement pumps they can produce high blood pressure, so they are the only ones suitable for pediatric patients. Therefore, they are indispensable for clinical use today and in the future. In this work, nearly all pulsatile blood pumps used in clinical life are described.

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Sieβ, T., H. Reul, and G. Rau. "Hydraulic Refinement of An Intraarterial Microaxial Blood Pump." International Journal of Artificial Organs 18, no. 5 (May 1995): 273–85. http://dx.doi.org/10.1177/039139889501800506.

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Intravascularly operating microaxial pumps have been introduced clinically proving to be useful tools for cardiac assist (1–4). However, a number of complications have been reported in literature associated with the extra-corporeal motor and the flexible drive shaft cable (5,6). In this paper, a new pump concept is presented which has been mechanically and hydraulically refined during the developing process. The drive shaft cable has been replaced by a proximally integrated micro electric motor and an extra-corporeal power supply (7). The conduit between pump and power supply consists of only an electrical power cable within the catheter resulting in a device which is indifferent to kinking and small curvature radii. Anticipated insertion difficulties, as a result of a large outer pump diameter, led to a two-step approach with an initial 6,4mm pump version and a secondary 5,4mm version. Both pumps meet the hydraulic requirement of at least 2.5I/min at a differential pressure of 80–100mmHg. The hydraulic refinements necessary to achieve the anticipated goal are based on ongoing hydrodynamic studies of the flow inside the pumps. Flow visualization on a 10:1 scale model as well as on 1:1 scale pumps have yielded significant improvements in the overall hydraulic performance of the pumps. One example of this iterative developing process by means of geometrical changes on the basis of flow visualization is illustrated for the 6.4mm pump.

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Matheve, Christiaan. "Centrifugal blood pumps." Perfusion 10, no. 3 (May 1995): 141–42. http://dx.doi.org/10.1177/026765919501000304.

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Ahmed, Azzam, Xianghui Wang, and Ming Yang. "Biocompatible materials of pulsatile and rotary blood pumps: A brief review." REVIEWS ON ADVANCED MATERIALS SCIENCE 59, no. 1 (August 10, 2020): 322–39. http://dx.doi.org/10.1515/rams-2020-0009.

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AbstractThe biomedical materials that have been used in the structure of heart pumps are classified as biocompatible, and these can be metals, polymers, ceramics, and composites. Their positions in the pump vary according to the part’s function. Whereas various materials have different properties, all biomaterials chosen for cardiovascular applications should have excellent blood biocompatibility to reduce the likelihood of hemolysis and thrombosis. There are two major categories of the heart pumps; pulsatile and rotary blood pumps (axial and centrifugal) and the features of some of these materials allow them to be used in both. Rotary and pulsatile blood pump devices have to be fabricated from materials that do not result in adverse biological responses. The purpose of this review is to study the available biocompatible materials for the pulsatile and rotary blood pumps as clinically-approved materials and prototype heart pump materials. The current state of bio-compatible materials of rotary and pulsatile blood pump construction is presented. Some recent applications of surface amendment technology on the materials for heart assist devices were also reviewed for better understanding. The limitations of heart assist devices, and the future direction of artificial heart elements have been considered. This review will be considered as a comprehensive reference to rapidly understanding the necessary research in the field of biocompatible materials of pulsatile and blood rotary pumps.

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Poder, Thomas, Jean-Christian Boileau, Renée Lafrenière, Louis Thibault, Nathalie Carrier, Marie-Joëlle De Grandmont, and Patrice Beauregard. "VP189 Hemolysis Induced By Modern Infusion Pumps During Blood Transfusion." International Journal of Technology Assessment in Health Care 33, S1 (2017): 236–37. http://dx.doi.org/10.1017/s0266462317004172.

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INTRODUCTION:Following a first field evaluation conducted in 2013, we found that hemolysis can be induced by infusion pumps during blood transfusion. Actually, limited data is available on the risk of hemolysis associated with the most used infusion pumps in Quebec hospitals: InfusomatSpace (peristaltic), Plum A+TM (piston) and ColleagueCXE (shuttle).METHODS:Staff from the blood bank and the Health Technology Assessment (HTA) unit in our hospital collaborated in 2016 to assess the hemolysis and potassium level (that is, a blood test sensitive to hemolysis) induced by the use of the three infusion pumps mentioned above. Measurements were taken for each pump at five flow rates, from 30 to 450 ml/hour, and were compared with measurements taken before using the pumps. Tests were conducted with 135 red blood cell (RBC) units. RBC units were aged from 10 to 28 days.RESULTS:The shuttle- and piston-type pumps resulted in low hemolysis levels. The peristaltic-type pump produced significantly more hemolysis. However, the absolute value of hemolysis remained within the range recommended by the regulatory agencies in North America and Europe. Potassium levels did not increase with the use of the pumps.CONCLUSIONS:The collaboration between the blood bank and the HTA unit led to the conclusion that modern infusion pumps widely used in Quebec hospitals produce non-threatening levels of hemolysis during blood transfusion. This finding is important to ensure safe practices.

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Wahba, A., A. Philip, MF Bauer, M. Kaiser, H. Aebert, and DE Birnbaum. "The blood saving potential of vortex versus roller pump with and without aprotinin." Perfusion 10, no. 5 (September 1995): 333–41. http://dx.doi.org/10.1177/026765919501000509.

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To evaluate the potential of centrifugal blood pumps for saving blood, 120 patients scheduled for elective coronary artery bypass grafting were entered into a prospective randomized trial. A standard roller pump (group I) was compared with a centrifugal blood pump (group II) and roller pump plus aprotinin (group III). There was no significant difference between groups I and I I with respect to free haemoglobin, lactic dehydrogenase, serum bilirubin, platelet surface glycoprotein IIb-IIIa and granule membrane protein 140, chest-tube drainage, use of blood products, length of stay in intensive care, time on ventilator and postoperative mortality. Aprotinin reduced chest-tube drainage and use of blood products significantly. Three cases of graft occlusions were noted in group III. Centrifugal blood pumps offer no advantage in routine heart surgery over conventional roller pumps. Aprotinin reduces blood loss, but does not influence GP IIb-IIIa and GMP 140 expression on blood platelets.

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Armignacco, Paolo, Francesco Garzotto, Corrado Bellini, Mauro Neri, Anna Lorenzin, Marco Sartori, and Claudio Ronco. "Pumps in Wearable Ultrafiltration Devices: Pumps in Wuf Devices." Blood Purification 39, no. 1-3 (2015): 115–24. http://dx.doi.org/10.1159/000368943.

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The wearable artificial kidney (WAK) is a device that is supposed to operate like a real kidney, which permits prolonged, frequent, and continuous dialysis treatments for patients with end-stage renal disease (ESRD). Its functioning is mainly related to its pumping system, as well as to its dialysate-generating and alarm/shutoff ones. A pump is defined as a device that moves fluids by mechanical action. In such a context, blood pumps pull blood from the access side of the dialysis catheter and return the blood at the same rate of flow. The main aim of this paper is to review the current literature on blood pumps, describing the way they have been functioning thus far and how they are being engineered, giving details about the most important parameters that define their quality, thus allowing the production of a radar comparative graph, and listing ideal pumps' features.

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Lawson, D. Scott, Derek Eilers, Suzanne Osorio Lujan, Maria Bortot, and James Jaggers. "Hemolysis generation from a novel, linear positive displacement blood pump for cardiopulmonary bypass on a six kilogram piglet: a preliminary report." Perfusion 32, no. 4 (November 18, 2016): 264–68. http://dx.doi.org/10.1177/0267659116679881.

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Background: Current blood pumps used for cardiopulmonary bypass generally fall into two different pump design categories; non-occlusive centrifugal pumps and occlusive, positive-displacement roller pumps. The amount of foreign surface area of extracorporeal circuits correlates with post-operative morbidity due to systemic inflammation, leading to a push for technology that reduces the amount of foreign surfaces. Current roller pumps are bulky and the tubing forms an arc in the pumping chamber (raceway), positioning the inlet 360 degrees from the outlet, making it very difficult to place the pump closer to the patient and to efficiently reduce tubing length. These challenges put existing roller pumps at a disadvantage for use in a compact cardiopulmonary bypass circuit. Centrifugal blood pumps are easier to incorporate into miniature circuit designs. However, the prime volumes of current centrifugal pump designs are large, especially for pediatric extracorporeal circuits where the prime volumes are too great to be of clinical value. Method: We describe a preliminary report on a novel, occlusive, linear, single-helix, positive-displacement blood pump which allows for decreased prime volume and surface area of the extracorporeal circuit. This new experimental pump design was used to perfuse a 6 kilogram piglet with a pediatric cardiopulmonary bypass circuit for two hours of continuous use. Blood samples were obtained every thirty minutes and assayed for plasma free hemolysis generation. Conclusions: The results from this initial experiment showed low plasma free hemoglobin generation and encourages the authors to further develop this concept.

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Dissertations / Theses on the topic "Blood pumps"

1

Westaby, Stephen. "Towards a realistic artificial heart." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248952.

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Mahmood, Amar Kays. "Optimisation of sealing and bearing technologies in rotary blood pumps." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400287.

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Bludszuweit, Catrin. "A theoretical approach to the prediction of haemolysis in centrifugal blood pumps." Thesis, University of Strathclyde, 1994. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21317.

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The successful use of centrifugal pumps as temporary cardiac assist devices strongly depends on the extent to which they damage blood. The development of a theoretical pump evaluation model was performed in this study to facilitate an effective pump optimisation. The optimisation process seeks to maximise flow performance and minimise blood trauma which is primarily caused by hydrodynamic stresses. A general mechanical blood damage theory was developed which comprises a combination of the information about mechanical loading of blood with the knowledge of its resistance properties. In this theory arbitrary loading-time functions are reduced to simple loading functions for which the damage behaviour is known. A linear damage accumulation theory contributes towards the determination of partial damages and their correlation in the overall damage process. The application of this novel blood damage prediction theory was demonstrated for haemolysis prediction in a commercial centrifugal blood pump. Particle loading-time functions were determined with a 3-dimensional numerical flow analysis of the entire pump domain by means of assigning scalar stress values to particle streaklines. Scalar stress values were obtained by a theory which enables the comparison of a six-component stress tensor with uniaxial stresses as applied in blood damage tests. It was shown that particles undergo a complex, irregularly fluctuating stress loading and that turbulent stresses and flow conditions in the outlet domain are the most critical factors. Haemolysis tests using an oscillating capillary tube setup were performed to investigate blood damage resistance properties under cyclic stress loading in hitherto unexplored amplitude and frequency ranges. A non-linear damage curve for stress amplitude-cycle number was derived which indicated the existence of an endurance strength for red blood cells. For the first time, detailed information about the mechanical loading of blood within a centrifugal pump has been obtained and linked to its traumatic effect. It offers the possibility for an effective, multi-parameter optimisation of blood pumps in the design phase.

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Slevar, Amy E. "Mechanical fatigue in a magnetically levitated axial blood pump /." Online version of thesis, 2007. http://hdl.handle.net/1850/4893.

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Gomez, Arnold David. "Control of a magnetically levitated ventricular assist device /." Online version of thesis, 2009. http://hdl.handle.net/1850/10611.

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YU, Hai [Verfasser], and Dominique [Akademischer Betreuer] Thevenin. "Flow design optimization of blood pumps considering hemolysis / Hai Yu. Betreuer: Dominique Thévenin." Magdeburg : Universitätsbibliothek, 2015. http://d-nb.info/1072685698/34.

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YU, Hai Verfasser], and Dominique [Akademischer Betreuer] [Thévenin. "Flow design optimization of blood pumps considering hemolysis / Hai Yu. Betreuer: Dominique Thévenin." Magdeburg : Universitätsbibliothek, 2015. http://nbn-resolving.de/urn:nbn:de:gbv:ma9:1-6390.

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Karantonis, Dean Electrical Engineering &amp Telecommunications Faculty of Engineering UNSW. "Control of a rotary blood pump." Publisher:University of New South Wales. Electrical Engineering & Telecommunications, 2008. http://handle.unsw.edu.au/1959.4/43474.

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Implantable rotary blood pumps (RBPs) are an emerging technology designed to provide sufferers of heart failure with a viable treatment option which improves their medical prognosis and quality of life. The broad aim of this thesis is to address the need for a pump control strategy, and develop a solution whereby the implant recipient??s physiological requirements are continuously monitored in a non-invasive manner and met with an appropriate response by the RBP. Employing only the non-invasive signal of instantaneous pump impeller speed to assess flow dynamics, five physiologically significant pumping states have been identified in acute ex vivo porcine experiments (N=6). Two broader states, corresponding to normal and ventricular suction conditions, were readily discernable in clinical data from human implant recipients (N=10). Employing a classification and regression tree (CART) model, an automated real-time algorithm was developed to detect pumping states with a high degree of sensitivity and specificity. Both suction and normal states were detected without error in data from the animal experiments, and with a peak sensitivity/specificity, for detecting suction, of 99.11% / 98.76% in the human patient data. Algorithms to non-invasively estimate RBP flow and differential pressure in both steady- and pulsatile-flow environments were developed. Taking the pump feedback signals of speed and power, together with the blood haematocrit (or equivalent viscosity) level, as input parameters, several estimation models were developed via polynomial surface fitting and/or system identification methods, yielding clinically acceptable results (mean flow errors of 3.09% and 5.49%, and mean pressure errors of 1.80% and 6.47%, for the steady- and pulsatile-flow cases, respectively). An RBP control algorithm based on a non-invasive indicator of the implant recipient??s activity level has been proposed and evaluated in a software simulation environment. An Activity Level Index (ALI) forms the basis of an adaptive control module operating within a hierarchical multi-objective framework which imposes several constraints on the pump??s operating region. Three class IV heart failure cases of varying severity were simulated under rest and exercise conditions, and a comparison with other popular RBP control strategies was performed. Simulations of the proposed control algorithm exhibited the effective intervention of each constraint, resulting in an improved flow response and the maintenance of a safe operating condition, compared with other control modes.

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Swalen, Marcel Johannes Petrus. "Study of a bi-directional axial flow blood pump." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6343.

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A common treatment for circulatory disorders is the application of rotary blood pumps to locally increase blood flow to required levels. Existing devices tend to support flow from inlet to outlet and in that direction only. This thesis presents a bi-directional pump that may enable ventricle assist devices (VAD) to support blood flow to the organs during systole, when rotating in one direction, and to increase coronary perfusion during diastole, when rotating in the other. For each flow direction blade profiles were designed and tested for performance. Both designs were merged to obtain a symmetric profile to provide flow support in both directions. This initial bi-directional design was optimised using computational fluid dynamics modelling. The model was set to accelerate to a maximum forward rotational speed of 8,000 rpm, change rotational direction after 300 ms and accelerate to 2,400 rpm whilst rotating backwards. Experimental testing was carried out to validate the computational results. In the forward direction, the pump was predicted to deliver 39 cm3 compared to 19 cm3 in the backward direction. Pressure heads reached maxima of 2.2 kPa in forward and 0.16 kPa in backward direction. Analysis of wall shear stress profiles at the blades’ surface showed that the maximum was 140 Pa lasting less than 300 ms in the forward direction, whilst in the backward direction this was approximately 23 Pa lasting for 700 ms. A design for the bi-directional blades is established and characterised computationally and experimentally. Analysis of the blade pressure profiles confirmed generation of pressure rise in both directions. The computational results for wall shear stress were predicted to be below the accepted limits of haemolysis. Recirculation zones were found at the outlet in the backward rotating direction. Future work may reduce those by using guide vanes at either side of the rotor.

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Rose, Michael Leon James. "Development of a muscle powered blood pump fluid mechanic considerations /." Thesis, Connect to electronic version, 1998. http://hdl.handle.net/1905/190.

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Thesis (Ph. D.)--University of Glasgow, 1998.
Thesis submitted to the Department of Cardiac Surgery, Faculty of Medicine, University of Glasgow, in fulfilment of the degree of Doctor of Philosophy. Print version also available.

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Books on the topic "Blood pumps"

1

Matsuda, Hikaru, ed. Rotary Blood Pumps. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2.

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Kaufman, Francine Ratner. Insulin pumps and continuous glucose monitoring. Alexandria, Va: American Diabetes Assocaiation, 2012.

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3

Gardner, A. M. N. The return of blood to the heart: Venous pumps in health and disease. London: J. Libbey, 1989.

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Gardner, A. M. N. The return of blood to the heart: Venous pumps in health and disease. 2nd ed. London: Libbey, 1993.

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Gardner, A. M. N. The return of blood to the heart: Venous pumps in health and disease. London: Libbey, 1989.

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Tyrone, Fernando, ed. Closed-loop control of blood glucose. Berlin: Springer, 2007.

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7

Steve, Parker. Pump it up!: Respiration and circulation. Chicago, Ill: Raintree, 2007.

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Steve, Parker. Pump it up!: Respiration and circulation. Chicago, Ill: Raintree, 2006.

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Stewart, Melissa. Pump it up!: The secrets of the heart and blood. New York: Marshall Cavendish Benchmark, 2010.

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10

Clinical application of intra-aortic balloon pump. 3rd ed. Armonk, N.Y: Futura Pub. Co., 1998.

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Book chapters on the topic "Blood pumps"

1

Yada, Isao, and Yu Shomura. "Physiology of Nonpulsatile Circulation." In Rotary Blood Pumps, 3–10. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_1.

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Nosé, Yukihiko. "Future of Rotary Blood Pumps." In Rotary Blood Pumps, 109–13. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_10.

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Montiès, Jean-Raoul, Jean Trinkl, Jean-Luc Demunck, Thierry Mesana, Patrick Havlik, and Thierry Caus. "CORA Rotary Blood Pump: Totally Sealed Bearings." In Rotary Blood Pumps, 115–22. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_11.

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Jett, G. Kimble. "Physiology of Nonpulsatile Circulation: Acute Versus Chronic Support." In Rotary Blood Pumps, 11–19. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_2.

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Tsutsui, Tatsuo. "Idioperipheral Pulsation During Nonpulsatile Circulation." In Rotary Blood Pumps, 21–31. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_3.

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Akamatsu, Teruaki, Tomonori Tsukiya, and Takayoshi Ozaki. "Fluid Engineering Aspect for Development of the Centrifugal Blood Pump with Magnetically Suspended Impeller." In Rotary Blood Pumps, 35–46. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_4.

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Golding, Leonard, William Smith, David Horvath, and Alexander Medvedev. "Rotodynamic Pump Development." In Rotary Blood Pumps, 47–56. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_5.

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Mitamura, Yoshinori, Masayuki Fujiyoshi, Ryohei Yozu, Shiaki Kawada, and Takashi Tanaka. "Development of an Intracardiac Axial Flow Pump." In Rotary Blood Pumps, 57–68. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_6.

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Siess, Thorsten, and Helmut Reul. "Basic Design Criteria for Rotary Blood Pumps." In Rotary Blood Pumps, 69–83. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_7.

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Nishida, Hiroshi, Masahiro Endo, and Hitoshi Koyanagi. "Rotary Blood Pumps: Paracorporeal, Implantable, or Percutaneous?" In Rotary Blood Pumps, 87–96. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67917-2_8.

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Conference papers on the topic "Blood pumps"

1

Day, Steven W. "Blood Flow Through Channels and Clearances in Implantable Pumps." In ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2007. http://dx.doi.org/10.1115/icnmm2007-30159.

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Implantable rotary blood pumps are very effective at supporting patients with heart failure. New designs demonstrate distinct advantages over their predecessor diaphragm type pumps and have generated vast interest in the medical devices community, as demonstrated by hundreds of technical publications and newer commercially available devices. In addition to mechanical design criteria, these pumps share the requirement of moving a relatively large amount of blood through a miniaturized pump without damaging the blood cells. The fluid channels within the impeller are typically 1–3 mm wide and the clearance between the blades, rotating at 2,000–10,000 rpm, and the stationary housing is approximately 100–300μm. This paper gives examples of experimental and numerical methods to characterize the flow field, and a summary of how the flow affects blood cells and design strategies to minimize blood damage.

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Yang, Xiao-chen, Yan Zhang, Xing-min Gui, and Sheng-shou Hu. "Computational Fluid Dynamics Analyses of a Micro Pediatric Ventricular Assist Blood Pump." In ASME-JSME-KSME 2011 Joint Fluids Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajk2011-06063.

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The heart failure patients supported by the mechanical rotary blood pumps have been validated and investigated in recent decades. A series of adult blood pumps have been investigated in our research group in the last several years and one of them is currently under clinical trials. This present paper aimed at analyzing a micro pediatric blood pump (MPBP) with Computational fluid dynamics (CFD) tool. MPBP is developed to assist the ventricular according to the practice of pediatric heart failure in Fuwai Hospital of Chinese Academy of Medical Sciences. The blade tip diameter of the MPBP is 10 mm. Some advanced structures proposed in our adult blood pumps were further improved in the MPBP and a cantilevered stator applied in the blood pump is a novel try. The results of the numerical simulation show that the MPBP can generate the flow rates of 0.74–3.21 lpm at the rotational speeds of 9,000–11,000 rpm, producing the pressure rises of 36.9–89.7 mmHg. The structural advantage, hydraulic performance and hemolytic property of the MPBP were analyzed in detail. Overall, the attempt of the cantilevered stator blade improved the performance of the blood pump effectively and the MPBP deserves a promising prospect.

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Jiang, M., T. Murashige, D. Sakota, and W. Hijikata. "Evaluating Plasma Skimming with Whole Blood in Small Gap Region Imitating Clearance of Blood Pumps." In 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2019. http://dx.doi.org/10.1109/embc.2019.8857735.

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Petukhov, Dmitry, Dmitry Telyshev, Marian Walter, and Leonie Korn. "An algorithm of system identification for implantable rotary blood pumps." In 2018 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT). IEEE, 2018. http://dx.doi.org/10.1109/usbereit.2018.8384550.

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Vollkron, M., H. Schima, L. Huber, B. Benkowski, G. Morello, and G. Wieselthaler. "Control of implantable axial blood pumps based on physiological demand." In 2006 American Control Conference. IEEE, 2006. http://dx.doi.org/10.1109/acc.2006.1655437.

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Xia, D. D., and J. Bai. "Simulation Study and Function Analysis of Micro-axial Blood Pumps." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1617097.

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Sugai, T. K., A. Tanaka, M. Yoshizawa, Y. Shiraishi, A. Baba, T. Yambe, and S. Nitta. "Influence of rotary blood pumps over preload recruitable stroke work." In 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010). IEEE, 2010. http://dx.doi.org/10.1109/iembs.2010.5627916.

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Girdhar, Gaurav, Michalis Xenos, Wei-Che Chiu, Yared Alemu, Bryan Lynch, Jolyon Jesty, Marvin Slepian, Shmuel Einav, and Danny Bluestein. "Design Optimization of Rotary Blood Pumps: Alternatives to Anticoagulation Therapy." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53171.

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Mechanical circulatory support (MCS) devices such as the ventricular assist devices (VADs) provide life saving short-term bridge-to-transplant solutions (1) to a large proportion of patients who suffer from chronic heart failure. Although hemodynamically efficient, such devices are burdened with high incidence of thromboembolic events due to non-physiological flow past constricted geometries where platelets (the principal cellular clotting elements in blood) are exposed to elevated shear stresses and exposure times (2) — requiring mandatory anticoagulation. We recently developed an optimization methodology — Device Thrombogenicity Emulator (DTE)(3) — that integrates device specific hemodynamic stresses (from numerical simulations) with experimental measurements of platelet activation. The DTE was successfully applied by our group to measure / optimize the thromboresistance of mechanical heart valves (MHV) (3, 4).

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Chen, Xin, and Jianping Tan. "Computational Prediction of Hemolysis by Blade Flow Field of Micro-Axial Blood Pump." In ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93910.

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By analyzing fluid dynamics of blood in an artificial blood pump and simulating the flow field structure and the flow performance of blood, the blood flow and the damages in the designed blood pump would be better understood. This paper describes computational fluid dynamic (CFD) used in predicting numerically the hemolysis of blade in micro-axial blood pumps. A numerical hydrodynamical model, based on the Navier-Stokes equation, was used to obtain the flow in a micro-axial blood pump. A time-dependent stress acting on blood particle is solved in this paper to explore the blood flow and damages in the micro-axial blood pump. An initial attempt is also made to predict the blood damage from these simulations.

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Gawlikowski, Maciej, Roman Kustosz, Maciej Głowacki, Paweł Pydziński, Krzysztof Kubacki, Michał Zakliczyński, Izabela Copik, and Jerzy Pacholewicz. "Non-invasive assessment of thromboembolism in rotary blood pumps: case study." In Twelfth Integrated Optics – Sensors, Sensing Structures and Methods Conference, edited by Tadeusz Pustelny and Przemyslaw Struk. SPIE, 2017. http://dx.doi.org/10.1117/12.2282667.

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