Relevant bibliographies by topics / Blood substitutes

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Blood substitutes'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Blood substitutes"

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Shamsul Bahrin, Safiah Syahirah, Siti Noor Fazliah Mohd Noor, Siti Salmah Noordin, Mohd Nadzri Mohd Najib, and Muhammad Azrul Zabidi. "CLASSIFICATION OF BLOOD SUBSTITUTES." Journal of Health and Translational Medicine sp2023, no. 1 (June 6, 2023): 261–77. http://dx.doi.org/10.22452/jummec.sp2023no1.28.

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Blood substitutes are substances used to replace or supplement the activities of biological blood cellular or acellular components. It is meant to be a transfusion-free option. There are four main categories that blood substitutes fall into: red blood cell substitutes, white blood cell substitutes, platelet substitutes, and plasma derivatives. Red blood cells (RBCs) substitutes can be divided into biological and chemical oxygen carriers. Biological oxygen carriers are haemoglobin-based oxygen carrier (HBOC) and stem cell derived red blood cells (cRBC). Sanguinate is the sole FDA-approved HBOC drug due to its sickle cell reversal, vasodilatory, and noninflammatory qualities while cRBC is utilized to produce universal group of RBCs. It has greater biological connections with natural bloods than chemical oxygen carriers, the second type of RBCs substitutes. When cRBC were transfused into participants, it was found that 63% of the cells continued to circulate in the blood, matching the half-life of a normal RBC, which is 28 days. These showed that red blood cells could be cultivated in a lab and that they also responded well in the human body. A study on stem cell derived red blood cells (cRBC) using growth stimulants, medium cultures, and genetic manipulation to immortalise human erythroid line has yielded mature RBCs. Now, this study is in the clinical trials which portrayed a huge success in the artificial blood field due to its immortal property. Perfluorocarbon (PFC) and polymer-based oxygen carriers are the two subcategories of chemical-based oxygen carriers. Products in this category may not be structurally resemble haemoglobin or RBCs, but they are intended to serve the primary physiological function of blood. Due to the complexity of the cellular parts of the immune system, no alternative to white blood cells (WBC) has been made artificially yet. However, immunotherapy strategies may offer the "functional substitution" for WBC especially in the case of artificial adaptive immunity. There have been approved alternatives for plasma derivatives but none to substitute platelets yet.
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Fromm, Robert E. "Blood substitutes." Critical Care Medicine 28, no. 6 (June 2000): 2150–51. http://dx.doi.org/10.1097/00003246-200006000-00091.

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Habib, Fahim A., and Stephen M. Cohn. "Blood substitutes." Current Opinion in Anaesthesiology 17, no. 2 (April 2004): 139–43. http://dx.doi.org/10.1097/00001503-200404000-00009.

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Palmer, Andre F., and Marcos Intaglietta. "Blood Substitutes." Annual Review of Biomedical Engineering 16, no. 1 (July 11, 2014): 77–101. http://dx.doi.org/10.1146/annurev-bioeng-071813-104950.

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Dietz, Niki M., Michael J. Joyner, and Mark A. Warner. "Blood Substitutes." Anesthesia & Analgesia 82, no. 2 (February 1996): 390–405. http://dx.doi.org/10.1097/00000539-199602000-00032.

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Mali, Shrikant Balasaheb. "Blood Substitutes." Journal of Craniofacial Surgery 26, no. 4 (June 2015): 1006–8. http://dx.doi.org/10.1097/scs.0000000000001611.

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Dietz, Niki M., Michael J. Joyner, and Mark A. Warner. "Blood Substitutes." Anesthesia & Analgesia 82, no. 2 (February 1996): 390–405. http://dx.doi.org/10.1213/00000539-199602000-00032.

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Winslow, Robert M. "Blood substitutes." Advanced Drug Delivery Reviews 40, no. 3 (February 2000): 131–42. http://dx.doi.org/10.1016/s0169-409x(99)00045-9.

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Cabrales, Pedro, and Marcos Intaglietta. "Blood Substitutes." ASAIO Journal 59, no. 4 (2013): 337–54. http://dx.doi.org/10.1097/mat.0b013e318291fbaa.

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Winslow, Robert M. "Blood substitutes." Current Opinion in Hematology 9, no. 2 (March 2002): 146–51. http://dx.doi.org/10.1097/00062752-200203000-00011.

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Dissertations / Theses on the topic "Blood substitutes"

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Guerra, Francisco. "Bloody Good: Pros of Synthetic Blood Substitutes." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/243889.

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In today's society we unfortunately have and will continue to face the effects of issues such as war, poverty, trauma, and death; all of which have had an impact on the lives of people within these societies, be it religious, medical or social. An important, yet subtle common denominator present within these issues is blood. Blood and its transfusion have had an enormous impact on these issues and disappointingly, today doctors have been facing increasing difficulties with providing blood to those who need it; mainly shortages and donor complications. Today and in past decades researchers and medical doctors have been increasing their focus on the study of blood and its many fascinating features so as to create a relatively ideal blood substitute. The focus of this thesis is to acknowledge the progressions being made in the creation of blood substitutes and to gain an understanding of the positive impacts it would have on society as a whole. With blood substitutes one would not have to worry about donors, infections, or shortages. We delve into a world full of issues related to blood where scientists strive to create a substance that can meet the important goal blood accomplishes; maintaining life.
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Guerra, Andres. "Bad Blood: Cons of Synthetic Blood Substitutes." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/243959.

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In recent years scientists have been attempting to develop synthetic blood substitutes in order to counter both the shortage in donor blood and the problems associated with infection and disease during allogeneic transfusion. Most attempts have been made at mimicking the oxygen carrying capabilities of red blood cells yet there is still a broad array of substances in use today that try to simulate the effects of whole blood, not just the red blood cell itself. This literature based thesis extensively discuses the importance of all blood components and reviews the recent developments and problems associated with volume expanders, oxygen carriers which are further subcategorized into hemoglobin-based substitutes and perfluorocarbons, erythropoietin use, and autologous blood transfusions. Their short term use has potential benefits but in the long term some of their shortcomings include hypertension, hypoproteinemia, thrombus formation, abnormal vasoactivity, anaphylaxis, and ischemic reperfusion injury, all of which tend to overshadow their benefits.
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Bentley, P. K. "Biocompatibility assessment of novel perfluorochemical emulsions." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293632.

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Armstrong, F. H. "Tissue responses to perfluorochemical emulsion components in rats." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276220.

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Ferreira, Margarida Lourenço. "New Artificial Blood Substitutes using Fluorinated Ionic Liquids." Master's thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2016. http://hdl.handle.net/10362/69823.

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"In the past decades, safe and effective artificial oxygen carriers (AOC), also named as “blood substitutes”, have been proposed and extensively studied in chemistry and medical science. The constant necessity of donor blood is crucial for diverse medical situations, such as accidents and casualties which result in acute blood loss and the need to restore oxygen transport to the tissues. The inherent complications associated to the traditional blood transfusion make urgent the formulation of new suitable alternatives.(1–4)(...)"
info:eu-repo/semantics/publishedVersion
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Alayash, Abdu I. "Hemoglobin-based blood substitutes : redox, signalling and clearance mechanisms." Thesis, University of Essex, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528868.

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Ning, Jing 1953. "Studies of perfluorochemical surfactant XMO-10 : effect on perfluorochemical blood substitutes." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64471.

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Mobed, Maryam. "Purification and characterization of carboxymethylchitin-coated liposomes encapsulating hemoglobin as potential blood substitutes." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60008.

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To increase the survival time of the liposome-based artificial red blood cells in vivo, bovine hemoglobin-loaded liposomes (LEHb) are coated with a polyanionic polymer. The purpose is to simulate the presence of a protective negative charge on the surface of living cells arising from the carboxylic extremities of sialoglycoproteins. In order to predict the in vivo response, the necessary experiments for the in vitro system characterization have been carried out.
The purified LEHbs display a unimodal size distribution in the submicron range. Analysis of the lipid/Hb content of the liposomes reveals that the variations in the Hb encapsulation efficiency (E$ sb{ rm Hb}$) as a function of the initial Hb concentration (Hb) $ sb{ rm o}$ are insignificant compared to the net augmentation of E$ sb{ rm Hb}$ as a function of the increasing initial lipid concentration. Meanwhile high (Hb) $ sb{ rm o}$s are necessary for the preservation of oxyhemoglobin. A comparative study suggests that FT-IR spectroscopy gives a more accurate quantitative adsorption index while the chitinase-based enzymatic assay should be used as a qualitative detection tool.
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Rainbow, Willa Augusta. "Regulation of circulation in the presence of blood substitutes: hormonal and renal influences." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1986. http://digitalcommons.auctr.edu/dissertations/2803.

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Oxy-Pherol-ET (OP-ET) is an artificial blood substitute composed of perfluoro~ributylamine (FC-43) emulsified with pluronic (FC-68) and hydroxyethyl starch as a plasma expander. This blood substitute is quite unique in that it has a high oxygen and carbon dioxide carrying capacity and is inert. In order for OP-ET to work, it must co-exist in circulation with blood components. This research project has been an investigation of the effect of OP-ET on the circulation regulatory agents (hormonal, etc). The aorta and vena cava were examined to assess the influence of OPET on the structural components of circulation. Since the kidney plays an important role in the overall regulation of circulation, the influence of the OP-ET on its function and structure were examined also. Stimulation of the renin-angiotensin system by hemorrhage, low sodium diet (LSD), and reduced renal perfusion pressure resulted in an increased release of renin in animals treated with OP-ET. Animals previously exchange-transfused with OP-ET were subsequently monitored daily for changes in weight, water intake, and urinary salt and water output. In OP-ET treated animals weight increase was when slow compared to control animals. The water intake of the animals exchange-transfused animals was substantially greater than control animals for the same time period. Animals prepared with indwelling catheters and exchange-transfused with OP-ET were monitored for their ability to respond to pharmacological concentrations of catecholamines and angiotensin II. Under these conditions animals showed no significant difference in blood pressure response when compared to control animals that were exchange-transfused with donor animals' RBCs and treated similarly with angiotensin and catecholamines. Previously transfused animals were monitored to determine the effect of OP-ET on the kidney. Under these conditions there was a diuretic-induced immediate increase in urinary sodium excretion and a gradual increase in urinary potassium. These were expected responses for this diuretic agent. Scanning electron microscopy (SEM) of exchange-transfused animals did not reveal observable differences within the endothelium of the aorta. The vena caval endothelium of the exchange-transfused animals showed no significant changes. There were no observable alterations in the glomerular capillaries by 7 days post-transfusion. The data warrant the conclusion that mechanisms which normally regulate the circulation still function in the presence of the blood substitutes used in this study. The use of OP-ET has great potential in emergency medicine and remote areas of the world where whole blood would be difficult to maintain.
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Hernandez, Adrian V., Erin E. Emonds, Brett A. Chen, Alfredo J. Zavala-Loayza, Priyaleela Thota, Vinay Pasupuleti, Yuani M. Roman, Antonio Bernabe-Ortiz, and J. Jaime Miranda. "Effect of low-sodium salt substitutes on blood pressure, detected hypertension, stroke and mortality." BMJ Publishing Group, 2019. http://hdl.handle.net/10757/652462.

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Objective A systematic review and meta-analysis was conducted to assess the efficacy of low-sodium salt substitutes (LSSS) as a potential intervention to reduce cardiovascular (CV) diseases. Methods Five engines and ClinicalTrials.gov were searched from inception to May 2018. Randomised controlled trials (RCTs) enrolling adult hypertensive or general populations that compared detected hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), overall mortality, stroke and other CV risk factors in those receiving LSSS versus regular salt were included. Effects were expressed as risk ratios or mean differences (MD) and their 95% CIs. Quality of evidence assessment followed GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology. Results 21 RCTs (15 in hypertensive (n=2016), 2 in normotensive (n=163) and 4 in mixed populations (n=5224)) were evaluated. LSSS formulations were heterogeneous. Effects were similar across hypertensive, normotensive and mixed populations. LSSS decreased SBP (MD-7.81 mm Hg, 95% CI-9.47 to-6.15, p<0.00001) and DBP (MD-3.96 mm Hg, 95% CI-5.17 to-2.74, p<0.00001) compared with control. Significant increases in urinary potassium (MD 11.46 mmol/day, 95% CI 8.36 to 14.55, p<0.00001) and calcium excretion (MD 2.39 mmol/day, 95% CI 0.52 to 4.26, p=0.01) and decreases in urinary sodium excretion (MD-35.82 mmol/day, 95% CI-57.35 to-14.29, p=0.001) were observed. Differences in detected hypertension, overall mortality, total cholesterol, triglycerides, glucose or BMI were not significant. Quality of evidence was low to very low for most of outcomes. Conclusions LSSS significantly decreased SBP and DBP. There was no effect for detected hypertension, overall mortality and intermediate outcomes. Large, long-term RCTs are necessary to clarify salt substitute effects on clinical outcomes.
Wellcome Trust
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Books on the topic "Blood substitutes"

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Winslow, R. M., K. D. Vandegriff, and M. Intaglietta, eds. Blood Substitutes. Boston, MA: Birkhäuser Boston, 1995. http://dx.doi.org/10.1007/978-1-4612-2576-8.

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Winslow, Robert M., Kim D. Vandegriff, and Marcos Intaglietta, eds. Blood Substitutes. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0.

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Swi, Chang Thomas Ming, and Geyer Robert P, eds. Blood substitutes. New York: Dekker, 1989.

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1941-, Winslow Robert M., Vandegriff Kim D, and Intaglietta Marcos, eds. Blood substitutes: New challenges. Boston: Birkhäuser, 1996.

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Winslow, Robert M., Kim D. Vandegriff, and Marcos Intaglietta, eds. Advances in Blood Substitutes. Boston, MA: Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-1976-7.

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1930-, Tsuchida E., ed. Artificial red cells: Materials, performances, and clinical study as blood substitutes. Chichester: Wiley, 1995.

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Liu, Henry, Alan D. Kaye, and Jonathan S. Jahr, eds. Blood Substitutes and Oxygen Biotherapeutics. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95975-3.

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Swi, Chang Thomas Ming, and International Symposium on Blood Substitutes (4th), eds. Blood substitutes and oxygen carriers. New York: Marcel Dekker, 1993.

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Inc, Medical Data International, ed. U.S. blood products markets: Blood substitutes and expanders. Irvine, Calif: Medical Data International, 1997.

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1930-, Tsuchida E., and International Symposium on Blood Substitutes (7th : 1997 : Waseda University), eds. Blood substitutes: Present and future perspectives. Amsterdam: Elsevier, 1998.

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Book chapters on the topic "Blood substitutes"

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Winslow, Robert M. "Blood Substitutes: 1995 in the Literature." In Blood Substitutes, 1–14. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_1.

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Winslow, Robert M. "Carbon Dioxide Transport by Hemoglobin-Based Blood Substitutes." In Blood Substitutes, 146–62. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_10.

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Rohlfs, Ronald J., and Kim D. Vandegriff. "Non-phospholipid Liposomes: A Novel Method for the Preparation of Hemoglobin Containing Lipid Vesicles." In Blood Substitutes, 163–84. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_11.

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Levin, Jack, Robert I. Roth, Wieslaw Kaca, Minora Yoshida, and Donghui Su. "Hemoglobin-Endotoxin Interactions." In Blood Substitutes, 185–202. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_12.

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Joyner, Michael J., and Ronald J. Faust. "Blood Substitutes: What is the Target?" In Blood Substitutes, 15–33. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_2.

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Kreimeier, U., and K. Messmer. "Blood Flow Distribution During Shock." In Blood Substitutes, 34–59. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_3.

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Winslow, Robert M. "Blood Substitute Oxygen Carriers Designed for Clinical Applications." In Blood Substitutes, 60–73. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_4.

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Motterlini, Roberto. "Interaction of Hemoglobin with Nitric Oxide and Carbon Monoxide: Physiological Implications." In Blood Substitutes, 74–98. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_5.

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Krishnamurti, Chitra, and Barbara M. Alving. "Biological Consequences of Cross-linked Hemoglobin in Animal Models of Surgery and Endotoxemia." In Blood Substitutes, 99–111. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_6.

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Bleeker, Wim, Jacques Agterberg, Erik La Hey, Gemma Rigter, Lily Zappeij, and Joa Bakker. "Hemorrhagic Disorders After Administration of Glutaraldehyde-polymerized Hemoglobin." In Blood Substitutes, 112–23. Boston, MA: Birkhäuser Boston, 1996. http://dx.doi.org/10.1007/978-1-4612-4114-0_7.

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Conference papers on the topic "Blood substitutes"

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Arakelian, A. G., D. V. Kochurov, A. A. Palamarchuk, and O. A. Shishakina. "Polymer blood substitutes." In ТЕНДЕНЦИИ РАЗВИТИЯ НАУКИ И ОБРАЗОВАНИЯ. НИЦ «Л-Журнал», 2018. http://dx.doi.org/10.18411/lj-11-2018-183.

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Ahsan, Taby, Adele M. Doyle, Garry P. Duffy, Frank Barry, and Robert M. Nerem. "Stem Cells and Vascular Regenerative Medicine." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193591.

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Vascular applications in regenerative medicine include blood vessel substitutes and vasculogenesis in ischemic or engineered tissues. For these repair processes to be successful, there is a need for a stable supply of endothelial and smooth muscle cells. For blood vessel substitutes, the immediate goal is to enable blood flow, but vasoactivity is necessary for long term success. In engineered vessels, it is thought that endothelial cells will serve as an anti-thrombogenic lumenal layer, while smooth muscle cells contribute to vessel contractility. In other clinical applications, what is needed is not a vessel substitute but the promotion of new vessel formation (vasculogenesis). A simplified account of vasculogenesis is that endothelial cells assemble to form vessel-like structures that can then be stabilized by smooth muscle cells. Overall, the need for new vasculature to transfer oxygen and nutrients is important to reperfuse not only ischemic tissue in vivo, but also dense, structurally complex engineered tissue. The impact of these vascular therapies, however, is limited in part by the low yield and inadequate in vitro proliferation potential of primary endothelial and smooth muscle cells. Thus, there is a need to address the cell sourcing issue for vascular cell-based therapies, potentially using stem cells.
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Pullens, Rolf A. A., Maria Stekelenburg, Carlijn V. C. Bouten, Frank P. T. Baaijens, and Mark J. Post. "3D Coculture of Human Endothelial Cells and Myofibroblasts for Vascular Tissue Engineering." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176099.

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Cardiovascular disease is still the number one cause of death in the industrialized world. Diseased small diameter blood vessels are frequently replaced by native grafts. However, these vessels have a limited life time [1], for example the patency at 10 year after coronary artery bypass grafting of saphenous vein grafts is 57% [2]. Tissue engineering (TE) of small diameter blood vessels seems a promising approach to overcome these shortcomings or address the increasing need for substitutes during follow up surgery. Mechanical conditioning of myofibroblast (MFs) seeded constructs appears to be beneficial for functional tissue properties, such as cell proliferation, ECM production and mechanical strength [3,4]. Without a functional endothelial cell (ECs) layer however, patency may be compromised by thrombogenecity. Construction of an EC layer might on the other hand affect the tissue composition during culture, as was shown for bovine ECs, which influenced proliferation and ECM production of smooth muscle cells [5].
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Sun, Wei, Elliot L. Chaikof, and Marc E. Levenston. "Development and Finite Element Implementation of a Nearly Incompressible Structural Constitutive Model for Artery Substitute Design." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193164.

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Compliance mismatch between a host artery and a vascular graft causes hemodynamic disturbance and stress concentration, which may lead to thrombus formation at an early stage and to neointimal hyperplasisa near the anastomosis at a later stage [1]. To optimal design artery substitutes, the requirements of geometric and compliance matching at mean blood pressure must be determined and used to guide the fabrication of the unloaded conduit with proper diameter and wall thickness. Given the range and complexity of structural behaviors that can be produced by independently varying structural properties of individual layers (fiber type, density, orientation and layer thickness), a sophisticated computational model is required to determine these conduit design parameters. In this paper, a novel nearly incompressible structural model was formulated and implemented into the commercial finite element code ABAQUS (Pawtucket, RI) for finite element artery inflation simulations. The profound artery compliance changes due to variations of fiber properties, the nearly incompressibility control parameter D, and different properties of intima-media and adventitia were investigated.
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Madhavan, Krishna, Walter Bonani, and Wei Tan. "Multilayer Hybrid Construct for Vascular Tissue Engineering." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53575.

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Vascular grafts are often used as blood vessel substitutes. Until now, synthetic materials have not matched the efficacy of native tissues, particularly in the applications of small-diameter vascular grafts (<6mm) such as bypass grafts for arthrosclerosis and vascular access graft for hemodialysis. There is a considerable need for alternatives to the autologous veins or arteries. Many patients do not have an autologous vessel suitable for use due to preexisting pathological conditions or previous surgical harvest. Recent developments in vascular tissue engineering demonstrate the possibility of a biodegradable graft material containing living cells to mimic the structure and function of native vessels. However, fabrication of biomimetic grafts is often time and labor intensive, and subsequently requires complicated storage. This demands technology advancements in producing vessel mimetic grafts, considering their availability in addition to efficacy. To this end, new approaches to constructing small-diameter grafts that are of immediate availability and capable of regenerating biomimetic blood vessels in vivo may address the unmet demand in this area. We have designed a novel multilayer vascular construct which is made up of a nanofibrous “intima-equivalent” with thrombus-resistant vessel lumen and a porous biopolymer matrix as “media-equivalent” to allow smooth muscle cells (SMC) from native artery to grow and remodel the tissue. In this study, various layering strategies have been explored. To evaluate the resultant multilayer construct, structural, biochemical and biomechanical characterizations, as well as cell assays and short-term animal studie have been performed.
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Kim, Jeehyun, Joseph W. Villard, Ho Lee, Marc D. Feldman, and Thomas E. Milner. "Murine myocardium OCT imaging with a blood substitute." In International Symposium on Biomedical Optics, edited by Valery V. Tuchin, Joseph A. Izatt, and James G. Fujimoto. SPIE, 2002. http://dx.doi.org/10.1117/12.470479.

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Kerdjoudj, H., V. Moby, N. Berthelemy, J. C. Voegel, P. Menu, and J. F. Stoltz. "Use of Polyelectrolyte Films in Vascular Tissue Engineering." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192538.

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Vascular diseases with their high morbidity and mortality are a major challenge for medical science, engaging the best minds in modern medicine. The development of antithrombogenic surfaces still remains a huge challenge in the vascular tissue engineering field. Various researchers have expanded surface coating procedures allowing endothelial cells (EC) adhesion and retention on vascular substitutes or by incorporating some of the mechanisms employed by vascular endothelial cells i.e. heparin. The short in vivo patency of these grafts is related. Our group study evaluates a new surface modification based on polyelectrolyte building. The layer by layer self assembly and the result in polyelectrolyte multilayer films (PEM) became also in a recent past a challenging, simple and versatile way to engineer surfaces with highly specific properties. Previous studies indicated that the poly(sodium-4 styrene sulfonate)/poly (allylamine hydrochloride) PSS/PAH multilayered films when ended by PAH induce strong adhesion and retention of mature EC which spread and keep their phenotype as well on glass [1,2], on expanded polytetrafluoroethylene ePTFE [3] and on cryopreserved arteries [4,5]. The mechanical properties (compliance), leading to early intimal hyperplasia and graft failure, were lost after artery cryopreservation. We have demonstrated the compliance restoration of PEM treated cryopreserved close to native arteries [5]. The use of an autologous EC source avoids the immunological rejections of the grafts. With an autologous origin, high proliferation capacity and potentialities to proliferate and differentiate into matures EC, the endothelial progenitor cells (EPC) have raised huge interest and offer new opportunities in vascular engineering. Currents protocols for isolation and differentiation of EPC from peripheral blood requires at least 1 month to observe an endothelium-like morphology and about 2 months for confluent EC monolayer. The EPC cultivated on PEM treated glasses showed a monolayer development after only 14 days of culture. The morphological appearance and mature phenotype markers expression and repartition of the monolayer cells are close to mature EC [6]. These main results have led to French patent deposit in June 2007[7].
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8

Zhang, Qingwei, Vadym Mochalin, Ioannis Neitzel, Yury Gogotsi, Peter I. Lelkes, and Jack Zhou. "The Study on PLLA-Nanodiamond Composites for Surgical Fixation Devices." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-38287.

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Biopolymers have a great potential in biomedical engineering, having been used as scaffolds for hard and soft tissues, such as bone and blood vessels for many years. More recently biopolymers have also found applications in surgical fixation devices. Compared with conventional metal fixation devices, bone grafts and organ substitutes, biopolymer products have advantages of no long-term implant palpability or temperature sensitivity, predictable degradation to provide progressive bone loading and no stress shielding, all of which leads to a better bone healing, reduced patient trauma and cost, elimination of second surgery for implant removal, and fewer complications from infections. However lack of initial fixation strength and bioactivity are two major concerns which limited more widespread applications of biopolymers in orthopedic surgery. Nanodiamond is attractive for its use in reinforcement of composite materials due to their outstanding mechanical, chemical and biological properties. Nanotechnology shows us many innovations and it is generally accepted view that many could be further developed and applied in tissue engineering. In this work, we conduct poly(L-lactic acid) (PLLA) and octadecylamine functionalized nanodiamond (ND-ODA) composite research to optimize the polymer/ND interface, thus to reinforce the mechanical strength. Composites comprising PLLA matrix with embedded ND-ODA were prepared by mixing PLLA/chloroform solution with chloroform suspension of nanodiamonds at concentrations of 0–10 by weight percent. The dispersion of ND-ODA was observed by transmission electron microscopy (TEM). TEM micrographs show that ND-ODA can disperse uniformly in PLLA till 10% wt. Nanoindentation result shows the mechanical strength of ND-ODA/PLLA composites improving following increasing the concentration of ND-ODA in composites. The noncytotoxicity of ND-ODA was demonstrated on 7F2 Osteoblasts. To test the usefulness of ND-ODA/PLLA composites as scaffolds for supporting cell growth, 7F2 Osteoblasts were cultured on scaffolds for 6 days. The attachment and proliferation of 7F2 on all scaffolds were assessed by fluorescent nuclear staining with Hoechst 33258 and Alamar BlueTM assay. The results showed that the adding ND-ODA does small influence cell growth, which indicates the composites have good biocompatibility. The morphology of 7F2 cells growing on all ND-ODA/PLLA composite scaffolds was determined by SEM, which confirms the Osteoblasts spread on the scaffolds. All these results combined suggest that ND-ODA/PLLA might provide a novel composite suitable for surgical fixation devices.
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Martin, John T., and Virginia L. Ferguson. "Regional Similarities in the Mechanical Properties of the Human Umbilical Artery." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206800.

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The human umbilical cord (UC) bridges the blood flow gap between baby and mother, protecting the blood supply in a way that allows the fetus freedom to move within the amniotic sac. Once the blood supply has been oxygenated by the maternal blood pool via the placenta, the umbilical vein (UV) provides a transport pathway to the fetus. Two umbilical arteries (UA) return the blood supply to the pool to eliminate CO2 and other metabolic wastes [1]. The walls of the UA’s and UV are made up of an intima composed a single layer of large, elongated endothelial cells [2], and a media composed of randomly distributed smooth muscles cells, collagen, elastin, and ground substance. These vessels are unique in that their adventitia is absent and substituted by Wharton’s jelly, a mucoid connective tissue.
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Glinkova, A., G. Radchikova, A. Marusich, E. Danilenko, and M. Djumkova. "Заменитель цельного молока в кормлении телят." In Scientific and practical conference with international participation: "Management of the genetic fund of animals – problems, solutions, outlooks". Scientific Practical Institute of Biotechnologies in Animal Husbandry and Veterinary Medicine, 2023. http://dx.doi.org/10.61562/mgfa2023.34.

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The use of whole milk substitute in feeding calves had a positive effect on the physiological state and metabolic processes in the animals' body. In the blood of calves of the experimental group, an increase in the concentration of hemoglobin by 1.9%, total protein by 3.9%, calcium by 3.8%, phosphorus by 2.3%, and a decrease in urea by 8.5% was found. Calves that consumed whole milk had the greatest productivity, and therefore, their gross increase over the experience was higher in relation to group II animals by 3.0%.Feed costs for the production of 1 kg of experimental animal products amounted to 3.53 feed units in the first group and 3.59 in the second. Feeding whole milk substitute to calves aged 10-60 days (group II) led to a decrease in the cost of: a daily ration by 4.6%, 1 feed unit by 3.7%.When feeding a whole milk substitute, The cost of feed for obtaining an increase decreased by 1.9%, the cost of the increase by 1.8%.
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Reports on the topic "Blood substitutes"

1

Kurtz, Donald M., and Jr. The Development of Non-Heme-Oxygen Carriers for Use in Blood Substitutes. Fort Belvoir, VA: Defense Technical Information Center, February 1996. http://dx.doi.org/10.21236/ada305833.

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2

Langer, Robert S. Proceedings of the XI Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology Held in Boston, Massachusetts on 24-27 July 1994,. Fort Belvoir, VA: Defense Technical Information Center, November 1994. http://dx.doi.org/10.21236/ada290342.

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3

Manning, James M. Carboxyalkylated Hemoglobin as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, November 1991. http://dx.doi.org/10.21236/ada252329.

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Manning, James M. Carboxyalkylated Crosslinked Hemoglobin as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, July 1995. http://dx.doi.org/10.21236/ada296762.

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Manning, James M. Carboxyalkylated Crosslinked Hemoglobin as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, March 1996. http://dx.doi.org/10.21236/ada306017.

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Winslow, Robert M. Current Issues in Blood Substitute Research and Development-1995. Fort Belvoir, VA: Defense Technical Information Center, September 1995. http://dx.doi.org/10.21236/ada299748.

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Burke, Thomas G. Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, March 1991. http://dx.doi.org/10.21236/ada233973.

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Burke, Thomas G. Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulations as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, November 1991. http://dx.doi.org/10.21236/ada243075.

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Burke, Thomas G. Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulations as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, November 1991. http://dx.doi.org/10.21236/ada244806.

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Burke, Thomas G. Evaluation of Liposome-Encapsulated Hemoglobin/LR16 Formulation as a Potential Blood Substitute. Fort Belvoir, VA: Defense Technical Information Center, January 1990. http://dx.doi.org/10.21236/ada229090.

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