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Journal articles on the topic 'Bluespace'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Brand, Diane. "Bluespace: a typological matrix for port cities." URBAN DESIGN International 12, no. 2-3 (2007): 69–85. http://dx.doi.org/10.1057/palgrave.udi.9000195.

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2

LAI, JENNIFER, ANTHONY LEVAS, PAUL CHOU, CLAUDIO PINHANEZ, and MARISA VIVEROS. "BlueSpace: personalizing workspace through awareness and adaptability." International Journal of Human-Computer Studies 57, no. 5 (2002): 415–28. http://dx.doi.org/10.1006/ijhc.2002.1028.

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3

Hu, Leiqiu, and Qi Li. "Greenspace, bluespace, and their interactive influence on urban thermal environments." Environmental Research Letters 15, no. 3 (2020): 034041. http://dx.doi.org/10.1088/1748-9326/ab6c30.

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4

Gunawardena, K. R., M. J. Wells, and T. Kershaw. "Utilising green and bluespace to mitigate urban heat island intensity." Science of The Total Environment 584-585 (April 2017): 1040–55. http://dx.doi.org/10.1016/j.scitotenv.2017.01.158.

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5

Brenes, Juan, Thomas D. Lagkas, Dimitrios Klonidis, et al. "A network slicing architecture for SDM and ARoF-based 5G fronthaul networks." Optical Communications and Networking 12, no. 4 (2020): B33—B43. https://doi.org/10.1364/JOCN.381912.

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The blueSPACE project focuses on the study of innovative technologies to overcome the limitations of current fronthaul networks. The key technology proposed is space-division multiplexing, which makes it possible to increase the capacity available in conventional single-mode fibers, effectively encompassing this capacity to the forecasted bandwidth demands imposed by 5G mobile communications. In this paper, we present the innovative optical fronthaul infrastructure proposed in the project and the tailored extensions to the European Telecommunications Standards Institute network function virtua

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6

Dzhambov, Angel M., Iana Markevych, Terry Hartig, et al. "Multiple pathways link urban green- and bluespace to mental health in young adults." Environmental Research 166 (October 2018): 223–33. http://dx.doi.org/10.1016/j.envres.2018.06.004.

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7

Amine, Ines, Alicia Guillien, Claire Philippat, et al. "Environmental exposures in early-life and general health in childhood." Environmental Health 22, no. 1 (2023): 53. https://doi.org/10.1186/s12940-023-01001-x.

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<strong>Background: </strong>Early-life environmental exposures are suspected to be involved in the development of chronic diseases later in life. Most studies conducted so far considered single or few exposures and single-health parameter. Our study aimed to identify a childhood general health score and assess its association with a wide range of pre- and post-natal environmental exposures.<strong>Methods: </strong>The analysis is based on 870 children (6–12 years) from six European birth cohorts participating in the Human Early-Life Exposome project. A total of 53 prenatal and 105 childhood

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Rommel, Simon, Monroy Idelfonso Tafur, Diego Pérez-Galacho, Josep Maria Fàbrega, Raül Muñoz, and Salvador Sales. "High-Capacity 5G Fronthaul Networks Based on Optical Space Division Multiplexing." Broadcasting 65, no. 2 (2019): 434–43. https://doi.org/10.1109/TBC.2019.2901412.

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The introduction of 5G mobile networks, bringing multi-Gbit/s user data rates and reduced latency, opens new opportunities for media generation, transport and distribution, as well as for new immersive media applications. The expected use of millimeter-wave carriers and the strong network densification resulting from a much reduced cell size-which enable the expected performance of 5G-pose major challenges to the fronthaul network. Space division multiplexing (SDM) in the optical domain has been suggested for ultra-high capacity fronthaul networks that naturally support different classes of fr

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9

Slawsky, Erik D., Joel C. Hoffman, Kristen N. Cowan, and Kristen M. Rappazzo. "Beneficial Use Impairments, Degradation of Aesthetics, and Human Health: A Review." International Journal of Environmental Research and Public Health 19, no. 10 (2022): 6090. http://dx.doi.org/10.3390/ijerph19106090.

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In environmental programs and blue/green space development, improving aesthetics is a common goal. There is broad interest in understanding the relationship between ecologically sound environments that people find aesthetically pleasing and human health. However, to date, few studies have adequately assessed this relationship, and no summaries or reviews of this line of research exist. Therefore, we undertook a systematic literature review to determine the state of science and identify critical needs to advance the field. Keywords identified from both aesthetics and loss of habitat literature

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10

Oswald, Tassia K., Alice R. Rumbold, Sophie G. E. Kedzior, Mark Kohler, and Vivienne M. Moore. "Mental Health of Young Australians during the COVID-19 Pandemic: Exploring the Roles of Employment Precarity, Screen Time, and Contact with Nature." International Journal of Environmental Research and Public Health 18, no. 11 (2021): 5630. http://dx.doi.org/10.3390/ijerph18115630.

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The coronavirus disease 2019 (COVID-19) pandemic is widely understood to have contributed to mental health problems. In Australia, young people (18–24 years) have been disproportionately affected. To date, research has predominantly focused on the presence or absence of mental illness symptoms, while aspects of mental well-being have been overlooked. We aimed to explore associations between potential risk and protective factors and mental health more comprehensively, using the Complete State Model of Mental Health. An online survey of 1004 young Australians (55% female; M age = 21.23) was unde

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11

Mueller, William, Paul Wilkinson, James Milner, et al. "Neighbourhood and path-based greenspace in three European countries: associations with objective physical activity." BMC Public Health 21, no. 1 (2021): 282. https://doi.org/10.1186/s12889-021-10259-0.

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<strong>Background: </strong>Greenspace has been associated with health benefits in many contexts. An important pathway may be through outdoor physical activity. We use a novel approach to examine the link between greenspace microenvironments and outdoor physical activity levels in the HEALS study conducted in Edinburgh (UK), the Netherlands, and Athens and Thessaloniki (Greece).<strong>Methods: </strong>Using physical activity tracker recordings, 118 HEALS participants with young children were classified with regard to daily minutes of moderate to vigorous physical activity (MVPA); 60 were cl

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12

Nikhil, Rishiyur S., and Arvind. "What is Bluespec?" ACM SIGDA Newsletter 38, no. 23 (2008): 1. http://dx.doi.org/10.1145/1862867.1862868.

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13

Nikhil, Rishiyur S., and Arvind. "What is Bluespec?" ACM SIGDA Newsletter 39, no. 1 (2009): 1. http://dx.doi.org/10.1145/1862876.1862877.

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14

Pitt, Hannah. "What prevents people accessing urban bluespaces? A qualitative study." Urban Forestry & Urban Greening 39 (March 2019): 89–97. http://dx.doi.org/10.1016/j.ufug.2019.02.013.

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15

Pitt, Hannah. "Muddying the waters: What urban waterways reveal about bluespaces and wellbeing." Geoforum 92 (June 2018): 161–70. http://dx.doi.org/10.1016/j.geoforum.2018.04.014.

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16

Wheaton, Belinda. "Adventure sports, risk, and human-more than human wellbeing: local responses to the challenges of the COVID-19 pandemic." Sociología del Deporte 2, no. 2 (2022): 23–40. http://dx.doi.org/10.46661/socioldeporte.6351.

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The impact of, and responses to COVID-19 has dominated discussion in every area of life, and fields of academic activity. In this paper I consider some of the impacts and considerations in relation to activities that have been conceptualised as adventure sports. My intention is not to show how adventure is being done differently, rather to use the exceptional circumstances of lockdown to highlighted the multifaceted, meaningful and affective ‘everyday’ experiences of those who engage in adventure sport as part of their everyday practices. My focus is empirical research conducted in Aotearoa Ne

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17

Richards, Dominic, and David Lester. "A monadic approach to automated reasoning for Bluespec SystemVerilog." Innovations in Systems and Software Engineering 7, no. 2 (2011): 85–95. http://dx.doi.org/10.1007/s11334-011-0149-0.

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18

Chung, Eric S., and James C. Hoe. "High-Level Design and Validation of the BlueSPARC Multithreaded Processor." IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 29, no. 10 (2010): 1459–70. http://dx.doi.org/10.1109/tcad.2010.2057870.

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19

Levallois-Barth, C. "Bluespam and the French National Commission on Data Protection (CNIL)." International Data Privacy Law 2, no. 1 (2011): 19–25. http://dx.doi.org/10.1093/idpl/ipr022.

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20

Kosta, Eleni, Peggy Valcke, and David Stevens. "‘Spam, spam, spam, spam … Lovely spam!’ Why is Bluespam different?" International Review of Law, Computers & Technology 23, no. 1-2 (2009): 89–97. http://dx.doi.org/10.1080/13600860902742513.

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21

Coleman, Tara, and Robin Kearns. "The role of bluespaces in experiencing place, aging and wellbeing: Insights from Waiheke Island, New Zealand." Health & Place 35 (September 2015): 206–17. http://dx.doi.org/10.1016/j.healthplace.2014.09.016.

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22

Kamkin, Alexander Sergeevich, Mikhail Mikhaylovich Chupilko, Mikhail Sergeevich Lebedev, Sergey Aleksandrovich Smolov, and Georgi Gaydadjiev. "Comparison of High-Level Synthesis and Hardware Construction Tools." Proceedings of the Institute for System Programming of the RAS 34, no. 5 (2022): 7–22. http://dx.doi.org/10.15514/ispras-2022-34(5)-1.

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Application-specific systems with FPGA accelerators are often designed using high-level synthesis or hardware construction tools. Nowadays, there are many frameworks available, both open-source and commercial. In this work, we attempt to fairly compare several existing solutions (languages and tools), including Verilog (our baseline), Chisel, Bluespec SystemVerilog (Bluespec Compiler), DSLX (XLS), MaxJ (MaxCompiler), and C (Bambu and Vivado HLS). Our analysis has been carried out using a representative example of 8×8 inverse discrete cosine transform (IDCT), a widely used algorithm engaged in,

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23

Chu, Slo Li, and Min Jen Lo. "A Novel Data-Oriented Methodology for Designing Complex SOC System with Bluespec SystemVerilog." Applied Mechanics and Materials 284-287 (January 2013): 2428–32. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.2428.

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The continuously growing of semiconductor technology makes the novel SOC system complicated and hard to design. Conventional timing-control methodology focuses on the synchronizing the registers in a digital system. However, the central control of huge amount of synchronous signals and states is difficult to maintain and design, the debugging and verification period is extended accordingly. This paper proposed a novel deign methodology, called data-oriented methodology, to overcome the above challenges, by using Bluespec SystemVerilog and the corresponding tools. The simple handshaking mechani

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24

Taylor, B. M., K. L. Rhodes, A. Marshell, and J. L. McIlwain. "Age-based demographic and reproductive assessment of orangespine Naso lituratus and bluespine Naso unicornis unicornfishes." Journal of Fish Biology 85, no. 3 (2014): 901–16. http://dx.doi.org/10.1111/jfb.12479.

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25

DeMartini, Edward E., Ross C. Langston, and Jeff A. Eble. "Spawning seasonality and body sizes at sexual maturity in the bluespine unicornfish, Naso unicornis (Acanthuridae)." Ichthyological Research 61, no. 3 (2014): 243–51. http://dx.doi.org/10.1007/s10228-014-0393-z.

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26

Taylor, Brett M. "Standing Out in a Big Crowd: High Cultural and Economic Value of Naso unicornis in the Insular Pacific." Fishes 4, no. 3 (2019): 40. http://dx.doi.org/10.3390/fishes4030040.

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Hundreds of fish species are harvested in coral-reef fisheries in the Indo-Pacific region using a variety of fishing gears. This diversity makes the economics, ecology, and management of reef-associated fisheries inherently complex. However, across insular fisheries spanning the tropical Pacific, one species consistently dominates contemporary fisheries catch: the bluespine unicornfish (Naso unicornis, Acanthuridae). I evaluated the relative contribution of N. unicornis to commercial fisheries in the insular Pacific region from long-term (>1 year) fishery surveys across various jurisdiction

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27

Boxshall, Geoffrey A. "A new genus of sea louse (Copepoda: Siphonostomatoida: Caligidae) parasitic on the bluespine unicornfish (Naso unicornis)." Folia Parasitologica 55, no. 3 (2008): 231–40. http://dx.doi.org/10.14411/fp.2008.031.

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28

DeMartini, Edward E. "Sexual Dimorphisms in the Bluespine Unicornfish,Naso unicornis(Acanthuridae): External Metrics for Movement Ecology and Life History." Copeia 104, no. 2 (2016): 498–505. http://dx.doi.org/10.1643/ce-15-270.

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29

Andrews, Allen H., Edward E. DeMartini, Jeff A. Eble, Brett M. Taylor, Dong Chun Lou, and Robert L. Humphreys. "Age and growth of bluespine unicornfish (Naso unicornis): a half-century life-span for a keystone browser, with a novel approach to bomb radiocarbon dating in the Hawaiian Islands." Canadian Journal of Fisheries and Aquatic Sciences 73, no. 10 (2016): 1575–86. http://dx.doi.org/10.1139/cjfas-2016-0019.

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Bluespine unicornfish (Naso unicornis) from Hawaii were aged to >50 years using cross-sectioned sagittal otoliths. Fish length was a poor indicator of age because of rapid and variable early growth, exemplified by fish aged to be 4 years near maximum length. Growth was deterministic with adult ages decoupled from body length. Otolith mass and thickness were evaluated as proxies for age and both were encouraging; thickness explained more variance but mass was easier to measure. An age estimation protocol was validated through ontogeny using bomb radiocarbon (14C) dating. Use of the postbomb

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30

Justine, JL, P. Leblanc, F. Keller, and RJG Lester. "Turbellarian black spot disease in bluespine unicornfish Naso unicornis in New Caledonia, caused by the parasitic turbellarian Piscinquilinus sp." Diseases of Aquatic Organisms 85 (July 23, 2009): 245–49. http://dx.doi.org/10.3354/dao02082.

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31

Hardman, Emily, John M. Green, M. Sabrina Desiré, and Sydney Perrine. "Movement of sonically tagged bluespine unicornfish,Naso unicornis, in relation to marine reserve boundaries in Rodrigues, western Indian Ocean." Aquatic Conservation: Marine and Freshwater Ecosystems 20, no. 3 (2010): 357–61. http://dx.doi.org/10.1002/aqc.1102.

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32

Meyer, Carl G., and Kim N. Holland. "Movement patterns, home range size and habitat utilization of the bluespine unicornfish, Naso unicornis (Acanthuridae) in a Hawaiian marine reserve." Environmental Biology of Fishes 73, no. 2 (2005): 201–10. http://dx.doi.org/10.1007/s10641-005-0559-7.

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33

Li, Xueqin, Lindsay C. Stringer, Sarah Chapman, and Martin Dallimer. "How urbanisation alters the intensity of the urban heat island in a tropical African city." PLOS ONE 16, no. 7 (2021): e0254371. http://dx.doi.org/10.1371/journal.pone.0254371.

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Due to the combined effects of urban growth and climate change, rapid urbanisation is particularly challenging in African cities. Areas that will house a large proportion of the urban population in the future coincide with where natural hazards are expected to occur, and where hazard risk management institutions, knowledge, and capacity are often lacking. One of the challenges posed by rapid urbanisation is the Urban Heat Island (UHI) effect, whereby urban areas are warmer than the surrounding rural areas. This study investigates urbanisation patterns and alterations in surface UHI (SUHI) inte

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34

Khan, Shihan N., Muneesh Tewari, Seungwoo Lee, et al. "High-Frequency Temperature Monitoring Detects Clinically Actionable Fevers Otherwise Missed By Standard-of-Care Monitoring during Treatment of Hematologic Malignancies." Blood 144, Supplement 1 (2024): 7500. https://doi.org/10.1182/blood-2024-194678.

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Introduction. Fever is an important marker of treatment-related adverse events in hospitalized patients undergoing treatment for hematologic malignancies. The use of non-invasive, wearable sensors for high-frequency temperature monitoring (HFTM) has been demonstrated to detect adverse febrile events earlier and more frequently than conventional, standard-of-care (SOC) nursing vitals. Given the increased sensitivity of event detection that is inherent with HFTM, a formal methodology for characterizing the clinical etiology of device-detected fevers becomes increasingly important for the develop

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35

Malek, Ehsan, Mary Hislop, Leland Metheny, et al. "Epigenetic Priming with Pre-Transplant Oral Panobinostat Followed By Post-Transplant Consolidation." Blood 138, Supplement 1 (2021): 2917. http://dx.doi.org/10.1182/blood-2021-151689.

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Abstract Despite the rich armamentarium of novel agents that are available to treat multiple myeloma (MM), high dose melphalan (HDM) and stem cell transplant (SCT) remain an essential therapy that achieves long-term durable remissions. However, most patients relapse following HDM-SCT due to the persistence of minimal residual disease (MRD). Therefore, there remains an unmet clinical need to overcome chemoresistant MRD and potentially achieve a cure for MM patients. Here, we describe a phase Ib trial designed to epigenetically priming with pre-transplant oral panobinostat to increase MRD sensit

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Malek, Ehsan, Farhad Sanati, Amanda Lauren, et al. "Mycobiome Supporting Diet to Reduce Gastrointestinal (GI)Toxicity Associated with Autologous Stem Cell Transplant (ASCT) for Patients with Multiple Myeloma (MM)." Blood 138, Supplement 1 (2021): 3948. http://dx.doi.org/10.1182/blood-2021-148226.

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Abstract Emerging data suggest healthy microbiome helps to protect against mucosal injury and inflammation. Dysbiosis results in biofilm formation in the gut which has been shown to be pro-inflammatory. MM patients potentially have significant dysbiosis result of long term corticosteroid use. Our group, previously showed that composition of microbiome presents at the pre-transplant period correlates with rate and degree of post-ASCT GI toxicities, neutropenic fever and neutrophilic engraftment among MM patients. Also, our data suggested a link between microbial communities at the count nadir a

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37

Eduafo, Augusta, Leland Metheny, Ravi Kyasaram, Farhad Sanati, James J. Driscoll, and Ehsan Malek. "Multidimensional Quantification of Exclusion Criteria to Reduce the Gap between Randomized Clinical Trial and Real-World Outcomes in Multiple Myeloma." Blood 138, Supplement 1 (2021): 4003. http://dx.doi.org/10.1182/blood-2021-148222.

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Abstract Randomized clinical trials (RCTs) are considered the highest level of evidence to define the efficacy of newly developed treatments before their adoption into clinical practice. RCTs incorporate exclusion criteria that eliminate specific patient populations in order to reduce the incidence of serious adverse events and enhance the efficacy of a given anti-cancer strategy. However, exclusion criteria may lead to a significant gap between patients (pts) enrolled on RCTs and real world pt populations, which represent the ultimate stakeholders in cancer treatment. The analysis of real-wor

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38

Eversman, Anna, Shufen Cao, Kirsten M. Boughan, et al. "Risk of Secondary Malignancy in CLL Patients Treated with Novel Targeted Agents." Blood 136, Supplement 1 (2020): 46–47. http://dx.doi.org/10.1182/blood-2020-140042.

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Background: The introduction of novel targeted agents that inhibit specific cellular pathways has improved the prognosis of chronic lymphocytic leukemia (CLL) patients. CLL patients have a higher risk of secondary malignancies, but this risk has not yet been defined for patients treated with targeted agents, including inhibitors of BTK, PI3K or BCL2. Methods: We conducted a retrospective cohort study of CLL patients managed at a large tertiary care center between 1994 and 2018. Patients were classified according to whether they were treated with cytotoxic chemotherapy alone, chemoimmunotherapy

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39

Kort, Jeries, Ravikumar Kyasaram, Shufen Cao, Pingfu Fu, James J. Driscoll, and Ehsan Malek. "Prognostic Value of Dynamic Monoclonal Protein Pattern on Probability of Myeloma Progression from the Precursor State." Blood 138, Supplement 1 (2021): 3781. http://dx.doi.org/10.1182/blood-2021-153265.

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Abstract Multiple Myeloma (MM) is a cancer of terminally differentiated plasma cell resides in bone marrow, which is always preceded by clinically asymptomatic precursor states. The process of malignant transformation however is not fully understood. Analyses of cells from precursor state have provided evidence that it is a genetically advanced lesion, wherein tumor cells carry many of the genetic changes found in MM cells. Furthermore, mice xenografts from patient (pt) with precursor disease showed progressive growth on its own suggesting progression potential is counteracted by active extrin

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Malek, Ehsan, Mary Hislop, Leland Metheny, et al. "Next-Generation Sequencing to Assess the Impact of Low Dose Melphalan on Residual Disease before High-Dose Melphalan and Stem Cell Transplant in Multiple Myeloma." Blood 138, Supplement 1 (2021): 4933. http://dx.doi.org/10.1182/blood-2021-148220.

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Abstract High-Dose Melphalan (HDM) followed by stem cell transplant (SCT) remains the standard-of-care for transplant-eligible patients newly-diagnosed with multiple myeloma (MM). However, ~1/3 of patients relapse &lt;2 years after undergoing HDM-SCT, indicating that melphalan-sensitivity is limited to a subset of patients and is currently not predictable. Currently, models that predict melphalan-resistance before proceeding to transplant are lacking. Rather, transplant-eligibility is defined mostly based on adequate organ function and performance status. Therefore, there is an urgent and

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Eduafo, Augusta, Leland Metheny, James Driscoll, et al. "Patient Selection Bias Limits the Real World Efficacy of Randomized Clinical Trials in Multiple Myeloma." Blood 136, Supplement 1 (2020): 1–2. http://dx.doi.org/10.1182/blood-2020-139856.

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Randomized clinical trials (RCT) are imperative for testing novel cancer therapies and advancing the science of cancer care. Exclusion criteria are employed to minimize toxicity and maximize benefit. However, the selection process introduces a deviation between enrolled patients (pts) and the real world population. Estimating how much the selected population deviates from the MM cohort at large may increase inclusiveness and could help define barriers to recruiting to MM studies. There has been significant advancement in treating Multiple Myeloma (MM) during the last decade. Over 16 FDA-approv

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Manjappa, Shivaprasad, Robert Fox, Jane Reese, et al. "Impact of Daratumumab on Stem Cell Collection, Graft Composition and Engraftment Among Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplant." Blood 136, Supplement 1 (2020): 35–37. http://dx.doi.org/10.1182/blood-2020-142115.

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Background High dose chemotherapy followed by autologous stem cell transplantation (ASCT) plays an important role in the treatment of transplant-eligible multiple myeloma (MM) patients and yields deep responses, prolongs progression-free survival (PFS) and overall survival (OS). Daratumumab (Dara), a humanized monoclonal antibody that binds to CD38+ on the surface of myeloma cells and is increasingly used upfront to treat MM. Up to 75% of mobilized CD34+ hematopoietic progenitors also express CD38 and, hence exposure to Dara may potentially impact stem cell mobilization, and, given the extende

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43

Ali, Naveed, Ana Carolina Pires de Rezende, Folashade Otegbeye, et al. "Final Results of a Dual-Institution Phase I Clinical Trial of Targeted Marrow Irradiation (TMI) Intensification of Reduced-Intensity Fludarabine/Busulfan (Flu/Bu) Conditioning for Allogeneic Hematopoietic Cell Transplantation for Medically Frail Patients with High-Risk Hematological Malignancies." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-142197.

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Background Reduced-intensity conditioning (RIC) regimens provide insufficient disease control in patients with high-risk hematological malignancies who are ineligible for myeloablative hematopoietic cell transplantation (HCT) due to advanced age or comorbidities. RIC fludarabine/busulfan (Flu/Bu) is generally well tolerated, but is associated with high relapse rates. We hypothesized that intensification of RIC Flu/Bu with targeted marrow irradiation (TMI) would be feasible and improve outcomes in such patients. Methods This dose escalation phase I clinical trial incorporated 3+3 design with ex

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Malek, Ehsan, E. Ricky Chan, Daniel Qu, et al. "Whole-Exome Sequencing Identifies a Somatic Cell Mutation Signature That Predicts Relapse Risk and Survival Probability in Multiple Myeloma." Blood 136, Supplement 1 (2020): 5. http://dx.doi.org/10.1182/blood-2020-142791.

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Introduction: Multiple myeloma (MM) is a plasma cell neoplasm associated with heterogeneous somatic alterations. Despite the development of novel anti-myeloma agents that have significantly prolonged patient survival, disease relapse remains a daunting problem. Our goal was to employ whole-exome sequencing (WES) to better describe the mutational landscape in MM beyond the tumor cell and identify genomic factors that might predict relapse. WES was performed using autograft samples obtained from MM patients that were then treated with high dose melphalan and autologous hematopoietic cell transpl

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Malek, Ehsan, Jeries Kort, Gi-Ming Wang, et al. "Development of a Machine Learning Algorithm for Rapid, Point-of-Care Prediction of Serum Monoclonal Proteins in Multiple Myeloma." Blood 136, Supplement 1 (2020): 13–15. http://dx.doi.org/10.1182/blood-2020-139733.

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Multiple Myeloma (MM) is a cancer of terminally-differentiated plasma cells residing in the bone marrow. Myeloma cells frequently secrete monoclonal proteins that can be used to assess tumor volume and patient response to therapy. Monoclonal proteins are measured by gel electrophoresis and subsequent immunofixation of the observed M-spike for protein typing. However, this a time-consuming process that may take up to 3-5 days that delays physician-patient decision-making, determining response to treatment and can be a significant psychological stressor for patients. Hence, there is an unmet nee

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46

Hong, Augustine, Augusta Eduafo, Hannah Schmikla, et al. "Analyzing Risk of Infection with Anti-CD38 Monoclonal Antibody Therapy for Patients with Multiple Myeloma." Blood 136, Supplement 1 (2020): 49. http://dx.doi.org/10.1182/blood-2020-140544.

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Monoclonal antibodies targeting CD38 are emerging as a mainstay of therapy for Multiple Myeloma (MM) in the relapse setting as well as upfront. These antibodies not only target CD38 on myeloma cells inducing anti-tumor pleiotropic effects, they also influence normal CD38-expressing cells, including normal plasma cells, natural killer cells and immunosuppressive regulatory cells (van de Donk et al , 2018). These cells play a key role in innate as well as humoral immunity and provide protection against a variety of infectious insults; hence, their depletion in MM patients (pts) can be expected t

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Kort, Jeries, Paolo F. Caimi, Pingfu Fu, et al. "Health Care Burden of Monogammopathy of Renal Significance." Blood 136, Supplement 1 (2020): 34–36. http://dx.doi.org/10.1182/blood-2020-139740.

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Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant, clonal plasma cell disorder, characterized by the presence of a monoclonal (M) protein in serum, &lt;10% clonal plasma cells in the bone marrow, and absence of end-organ damage attributable to multiple myeloma (MM). MGUS incidence is estimated as 0.3% and 3% among those &lt;50 years and &gt;50 years, respectively. Although renal failure is a defining feature of MM, frequently patients (pts) with a variety of renal pathologies have less than 10% plasma cell burden in the bone marrow, therefore they cannot b

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Metheny, Leland, Ronald M. Sobecks, Christina Cho, et al. "Post-Transplant Inotuzumab Ozogamicin for Acute Lymphoblastic Leukemia." Blood 138, Supplement 1 (2021): 2899. http://dx.doi.org/10.1182/blood-2021-153041.

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Abstract Background: The curative potential of allogeneic transplant (alloHCT) in patients with acute lymphoblastic leukemia (ALL) is hampered by relapse; the major cause of treatment failure. Risk factors for relapse include measurable residual disease (MRD) before or after alloHCT, transplantation in second complete remission (CR) or beyond, and reduced intensity conditioning (RIC) regimens. In ALL patients, relapse rates range from 30% to 50%, with most relapses occurring within the first year after alloHCT. After relapse, options for disease control are limited, and consequently overall su

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Costa, Luciano J., Robert Frank Cornell, Natalie S. Callander, et al. "Efficacy of Treatments for Patients with Triple-Class Refractory (TCR) Multiple Myeloma (MM): Benchmark for New Agents Utilizing Real-World Data (RWD)." Blood 138, Supplement 1 (2021): 3786. http://dx.doi.org/10.1182/blood-2021-144387.

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Abstract Background: MM that is refractory to a proteasome inhibitor (PI), an immunomodulatory agent (IMiD) and an anti-CD38 monoclonal antibody (CD38MoAb) is labeled triple-class refractory (TCR) and recognized as a modern therapeutic challenge. In recent years, new agents have shown activity in this setting in single arm trials and many more are in development. The assessment of the impact of new agents in the TCR setting is impaired by limited information on the therapeutic outcomes of these patients when treated with non-investigational therapies. Methods: We utilized an independent RWD da

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Chung, David J., Nina Shah, Dina Stroopinsky, et al. "Impact of Autologous Hematopoietic Cell Transplant (HCT) Followed By Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance in Increasing Multiple Myeloma (MM) Immunity (BMT CTN 1401)." Blood 138, Supplement 1 (2021): 899. http://dx.doi.org/10.1182/blood-2021-149659.

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Abstract In a prior phase 2 study, personalized cancer vaccination with autologous dendritic cells (DCs) fused with primary MM tumor cells (DC/MM fusions) induced the expansion of circulating MM-reactive lymphocytes and was associated with conversion to complete response (CR) post-autoHCT in the absence of maintenance therapy. 1 We now present a multicenter randomized phase II study that examined the efficacy of DC/MM fusion vaccination with lenalidomide maintenance therapy after autoHCT, compared with lenalidomide maintenance alone. The study offered a first-of-its-kind academic collaborative

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