Dissertations / Theses: 'Blys'

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Ng, Man-wai. "Association of B lymphocyte stimulator (BLyS) polymorphisms with systemic lupus erythematosus (SLE)." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32053022.

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Ng, Man-wai, and 吳雯慧. "Association of B lymphocyte stimulator (BLyS) polymorphisms with systemic lupus erythematosus (SLE)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32053022.

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Stevenson, Calum. "Database mining studies on protein-peptide and protein-protein interactions." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7644.

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A major area of interest is the identification of proteins that play a role in hormone dependent cancers and in collaboration with the MRC Centre for Reproductive Health we studied the gonadotropin releasing hormone receptor (GnRH-R). Other targets described in the thesis are the SH3 domain of PSD-95 and the protein BLyS. In order to identify potential inhibitory small molecules we have used a variety of computational data base mining approaches as well as using and developing experimental binding assays. It has become increasingly challenging to evaluate the most representative drug like small molecule compounds when using traditional high throughput screening methods. This thesis assesses the use of in silico tools to probe key protein-protein and protein-peptide interactions. These tools provide a means to identify enriched compound datasets which can be purchased and tested in vitro in a time and cost efficient way. The transmembrane protein GnRH-R provides an interesting opportunity to identify small molecules that could inhibit the binding of its peptide ligand GnRH. This is a challenging project as there are few examples in the literature of drug-like molecules that bind to such protein-peptide interfaces. The first step involved receptor modelling using solved crystal structures of homologous proteins. The model was then validated by developing structure activity relationships for established high affinity ligands. We also performed crystallographic and biophysical studies on the native GnRH decapeptide. Two other protein-protein systems were also examined using the same virtual screening and experimental ligand binding methodology. SH3 domains play an important role in cell signalling and we used the PSD-95 protein as our target for study as a crystal structure has been published. As well as identifying potential ligands we characterised structural properties of PSD-95 fusion proteins and also developed the basis for compound assay. The third system studied was B Lymphocyte Stimulator (BLyS) which is a target for treatment of a number of autoimmune diseases. This presented an interesting target for study as the protein binds to multiple receptors depending on its multimeric state. BLyS protein was characterised using electron microscopy and other biophysical techniques.

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Capobianco, Marcela Petrolini [UNESP]. "Polimorfismos dos Genes CD40, CD40L e BLYS, associados na co-estimulação dos Linfócitos B, em indivíduos naturalmente infectados pelo Plasmodium vivax na Amazônia Brasileira." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92537.

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Made available in DSpace on 2014-06-11T19:26:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-22Bitstream added on 2014-06-13T18:29:26Z : No. of bitstreams: 1 capobianco_mp_me_sjrp.pdf: 879411 bytes, checksum: 7dc3528f12158026ba11087f62447e13 (MD5)
Plasmodium vivax é a espécie mais prevalente de malária no Brasil. O processo co-evolutivo parasita-hospedeiro pode ser visto como uma ferramenta, na qual trocas genéticas adaptativas podem influenciar na diversidade da população. Objetivo: Investigar polimorfismos de genes envolvidos na resposta imune humoral visando identificar possíveis associações com a malária. Material e Métodos: a amostra foi constiuída por 103 pacientes com malária vivax não complicada e como grupo controle 97 indíviduos não-maláricos. A identificação dos SNPs –726T>C no gene CD40L, -1 C>T no gene CD40 e -871C>T no gene BLYS foram efetuadas pelo método de PCR-RFLP. As frequências genotípicas, alélicas e de indivíduos portadores de cada alelo foram estimadas por contagem direta. Também foram comparadas as frequências genotípicas observadas com as esperadas segundo o teorema de Hardy e Weinberg. Resultados: As freqüências genotípicas e alélicas para esses SNPs não diferiram estatisticamente entre pacientes e indivíduos do grupo controle. A combinação dos genótipos entre os genes CD40 e BLYS e entre CD40L e BLYS não revelou interação gênica na população estudada. Não foi observada associação entre resposta imune humoral e parasitemia nos indivíduos maláricos com os polimorfismos dos genes investigados. Ambos os genes se encontram em equilíbrio de Hardy e Weinberg. Conclusões: Os resultados deste estudo sugerem que as variantes genéticas analisadas nos genes CD40, CD40L e BLYS não afetam a funcionalidade das moléculas de modo que possa interferir na susceptibilidade a doença, mas estas variantes podem influenciar o curso clínico em vez de simplesmente aumentar ou diminuir a susceptibilidade
Plasmodium vivax is the most prevalent malaria species in Brazil. The parasite-host coevolutionary process can be viewed as an ‘arms race’, in which adaptive genetic changes in one are eventually matched by alterations in the other. Objectives: following the candidate gene approach we analyzed the CD40, CD40L and BLYS genes that participate in B-cell co-stimulation, for associations with P. vivax malaria. Methods: the study sample included 97 patients and 103 controls. We extracted DNA using the extraction and purification commercial kit and identified the following SNPs: -1C>T in the CD40 gene, –726T>C in the CD40L gene and the -871C>T in the BLyS gene using PCR-RFLP. We analyzed the genotype and allele frequencies by direct counting. We also compared the observed with the expected genotype frequencies using the Hardy-Weinberg Equilibrium. Results: The allele and genotype frequencies for these SNPs did not differ statistically between patient and control groups. Gene-gene interactions were not observed between the CD40 and BLYS and between the CD40L and BLYS genes. Overall, the genes were in Hardy-Weinberg Equilibrium. Significant differences were not observed among the frequencies of antibody responses against P. vivax sporozoite and erythrocytic antigens and the CD40 and BLYS genotypes Conclusions: the results of this study show that, although the investigated CD40, CD40L and BLYS alleles differ functionally, this variation does not alter the functionality of the molecules in a way that would interfere in susceptibility to the disease. Significance: The variants of these genes may influence the clinical course rather than simply increase or decrease susceptibility

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Capobianco, Marcela Petrolini. "Polimorfismos dos Genes CD40, CD40L e BLYS, associados na co-estimulação dos Linfócitos B, em indivíduos naturalmente infectados pelo Plasmodium vivax na Amazônia Brasileira /." São José do Rio Preto, 2013. http://hdl.handle.net/11449/92537.

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Orientador: Ricardo Luiz Dantas Machado
Banca: Ana Elizabete Silva
Banca: Karin Kirchgatter
Resumo: Plasmodium vivax é a espécie mais prevalente de malária no Brasil. O processo co-evolutivo parasita-hospedeiro pode ser visto como uma "ferramenta", na qual trocas genéticas adaptativas podem influenciar na diversidade da população. Objetivo: Investigar polimorfismos de genes envolvidos na resposta imune humoral visando identificar possíveis associações com a malária. Material e Métodos: a amostra foi constiuída por 103 pacientes com malária vivax não complicada e como grupo controle 97 indíviduos não-maláricos. A identificação dos SNPs -726T>C no gene CD40L, -1 C>T no gene CD40 e -871C>T no gene BLYS foram efetuadas pelo método de PCR-RFLP. As frequências genotípicas, alélicas e de indivíduos portadores de cada alelo foram estimadas por contagem direta. Também foram comparadas as frequências genotípicas observadas com as esperadas segundo o teorema de Hardy e Weinberg. Resultados: As freqüências genotípicas e alélicas para esses SNPs não diferiram estatisticamente entre pacientes e indivíduos do grupo controle. A combinação dos genótipos entre os genes CD40 e BLYS e entre CD40L e BLYS não revelou interação gênica na população estudada. Não foi observada associação entre resposta imune humoral e parasitemia nos indivíduos maláricos com os polimorfismos dos genes investigados. Ambos os genes se encontram em equilíbrio de Hardy e Weinberg. Conclusões: Os resultados deste estudo sugerem que as variantes genéticas analisadas nos genes CD40, CD40L e BLYS não afetam a funcionalidade das moléculas de modo que possa interferir na susceptibilidade a doença, mas estas variantes podem influenciar o curso clínico em vez de simplesmente aumentar ou diminuir a susceptibilidade
Abstract: Plasmodium vivax is the most prevalent malaria species in Brazil. The parasite-host coevolutionary process can be viewed as an 'arms race', in which adaptive genetic changes in one are eventually matched by alterations in the other. Objectives: following the candidate gene approach we analyzed the CD40, CD40L and BLYS genes that participate in B-cell co-stimulation, for associations with P. vivax malaria. Methods: the study sample included 97 patients and 103 controls. We extracted DNA using the extraction and purification commercial kit and identified the following SNPs: -1C>T in the CD40 gene, -726T>C in the CD40L gene and the -871C>T in the BLyS gene using PCR-RFLP. We analyzed the genotype and allele frequencies by direct counting. We also compared the observed with the expected genotype frequencies using the Hardy-Weinberg Equilibrium. Results: The allele and genotype frequencies for these SNPs did not differ statistically between patient and control groups. Gene-gene interactions were not observed between the CD40 and BLYS and between the CD40L and BLYS genes. Overall, the genes were in Hardy-Weinberg Equilibrium. Significant differences were not observed among the frequencies of antibody responses against P. vivax sporozoite and erythrocytic antigens and the CD40 and BLYS genotypes Conclusions: the results of this study show that, although the investigated CD40, CD40L and BLYS alleles differ functionally, this variation does not alter the functionality of the molecules in a way that would interfere in susceptibility to the disease. Significance: The variants of these genes may influence the clinical course rather than simply increase or decrease susceptibility
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Banham, Gemma. "Investigation of novel therapeutic strategies in B cell and antibody mediated disease." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/286226.

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Terminally differentiated B cells are responsible for antibody generation, a key component of adaptive immunity. IgG antibodies play an important role in defence against infection but can be pathogenic in some autoimmune diseases and in solid organ transplantation. In addition to antibody generation, there is increasing interest in the antibody-independent functions of B cells, including their ability to regulate immune responses via the production of IL10. In this thesis I firstly explored the therapeutic potential of belimumab, an anti-BLyS antibody, in an experimental medicine study in kidney transplant recipients. The rationale for this study was based on published studies showing that B cells activate alloreactive T cells and secrete human leukocyte antigen (HLA) and non-HLA antibodies that negatively affect graft function and survival, but may also play a protective role by regulating alloimmune responses promoting transplant tolerance. B-Lymphocyte Stimulator (BLyS) is a cytokine that promotes B cell activation and survival. We performed the first randomized controlled trial using belimumab as early maintenance immunosuppression in kidney transplantation. In belimumab-treated subjects, we demonstrate a reduction in naïve and activated memory B cells, plasmablasts, IgG transcripts in peripheral blood and new antibody formation as well as evidence of reduced CD4 T cell activation and of a skewing of the residual B cell compartment towards an IL10-producing regulatory phenotype. This experimental medicine study highlights the potential of belimumab as a novel therapeutic agent in transplantation. In the second part of my project I performed a preclinical study investigating the potential efficacy of bromodomain inhibitors in reducing antibody-mediated immune cell activation. Immune complexed antigen can activate mononuclear phagocytes (MNP), comprising macrophages and dendritic cells (DCs), via ligation of Fc gamma receptors (FcγR), that bind the Fc region of IgG. FcγR-dependent MNP activation results in profound changes in gene expression that mediate antibody effector function in these cells. The resulting inflammatory response can be pathological in the setting of autoimmune diseases, such as systemic lupus erythematosus and in antibody-mediated rejection in transplantation. BET proteins are a family of histone modification 'readers' that bind acetylated lysine residues within histones and function as a scaffold for the assembly of complexes that regulate gene transcription. Bromodomain inhibitors (I-BET) selectively inhibit the transcription of a subset of inflammatory genes in macrophages following toll-like receptor stimulation. Since MNPs make a key contribution to antibody-mediated pathology, we sought to determine the extent to which I-BET inhibits macrophage and DC activation by IgG. We show that I-BET delays phagolysosome maturation associated with build-up of immune complex (IC) whilst selectively inhibiting IC induced cytokine production. I-BET changed MNP morphology, resulting in a less adherent phenotype, prompting an assessment of its impact on DC migration. In vitro, in a three-dimensional collagen matrix, IgG-IC induced augmentation of DC chemotaxis to chemokine (C-C motif) ligand 19 (CCL19) was abrogated by the addition of I-BET. In vivo, two photon imaging showed that systemic I-BET treatment reduced IC-induced dermal DC mobilisation. Tissue DCs and transferred DC also had reduced migration to draining lymph nodes following I-BET treatment. These observations provide mechanistic insight into the potential therapeutic benefit of I-BET in the setting of antibody-associated inflammation.

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Sturm, Anna Katharina Verfasser], Johann O. [Akademischer Betreuer] [Schröder, and Michael [Gutachter] Weichenthal. "Einfluss der Krankheitsaktivität und der Therapiedauer auf die Wirksamkeit des BLYS-Inhibitors Belimumab bei Systemischem Lupus Erythematodes - Langzeituntersuchung an einer monozentrischen Lupuskohorte / Anna Katharina Sturm ; Gutachter: Michael Weichenthal ; Betreuer: Johann Oltmann Schröder." Kiel : Universitätsbibliothek Kiel, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:8-mods-2020-00240-1.

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Sturm, Anna Katharina [Verfasser], Johann Oltmann [Akademischer Betreuer] Schröder, and Michael [Gutachter] Weichenthal. "Einfluss der Krankheitsaktivität und der Therapiedauer auf die Wirksamkeit des BLYS-Inhibitors Belimumab bei Systemischem Lupus Erythematodes - Langzeituntersuchung an einer monozentrischen Lupuskohorte / Anna Katharina Sturm ; Gutachter: Michael Weichenthal ; Betreuer: Johann Oltmann Schröder." Kiel : Universitätsbibliothek Kiel, 2020. http://d-nb.info/1215098235/34.

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Lien, Geir Josten. "Auto-tunable GPU BLAS." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for datateknikk og informasjonsvitenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-18411.

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In this paper, we present our implementation of an Auto tuning system, written in C++, which incorporate the use of OpenCL kernels. We deploy this approach on different GPU architectures, evaluating the performance of the approach. Our main focus is to easily generate tuned code, that would otherwise require a large amount of empirical testing, and then run it on any kind of device. This is achieved through the auto tuning framework, which will create different kernels, compile and run them on the device and output the best performing kernel on the given platform.BLAS is much used in performance critical applications, and is a good candidate for execution on GPUs due to its potential performance increase. Our implementation was benchmarked on various of test environments, with different GPUs, where we achieved comparable results to the ViennaCL library. We also tested against the native vendor specific BLAS libraries from AMD and NVIDIA.

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Kaplan, Steven. "Robert Bly and Randall Jarrell as translators of Rainer Maria Rilke : a study of the translations and their impact on Bly's and Jarrell's own poetry /." Frankfurt am Main : P. Lang, 1989. http://catalogue.bnf.fr/ark:/12148/cb36654972k.

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Urban, Jakub. "Inovace laboratorních úloh v BLOS." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2019. http://www.nusl.cz/ntk/nusl-400647.

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This thesis deals with innovation of tasks from bachelor subject Logical systems. Three tasks in total in VHDL language were designed and tested for development kit Digilent Nexys 3 and peripheries Pmod which are connected to it. First task is focused on reading pressed key on matrix keyboard. Second and third tasks targets on displaying pressed key on OLED display, they differ by used controller for this display. Instructions for all tasks were created.

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Martin-Hernandez, Évelyne. "L'oeuvre poétique de Blas de Otero." Poitiers, 1991. http://www.theses.fr/1991POIT5003.

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Blas de otero est un poete basque dont la production poetique, ecrite en langue espagnole, correspond a la periode 1941-1979. Le theme religieux inspire ses premiers livres, cependant il faut distinguer une premiere epoque de dependance du sujet a l'egard de dieu, une parole mystique, et une seconde phase de rebellion contre un dieu qui autorila guerre. C'est la que se forge une parole de rupture, blasphematoire. La production "engagee" de blas de otero, publiee a partir de 1960, traite de l'homme dans son rapport a ses semblables et a son temps. L'histoire, le reel sont des themes centraux, et le discours est essentiellement polemique. Il prend a cpntre-pied le discours officiel et sa vision du present et du passe, restaurant ainsi un courant de pensee "heterodoxe". Le paysage espagnol se trouve egalement arrache a la culture dominante. Dans des compositions souvent inspirees par les arts plastiques, le descriptif se charge de traits symboliques et la poesie s'y fait parole d'agitation. Toujours tendue vers l"immense majorite", la langue poetique incorpore langage populaire et oralite, ainsi que nombre de citations d'auteurs. Elle tend vers l'art du dire "vrai", de la transparence, de l'effacement du sujet
Blas de otero is a basque poet whose literary output, written in spanish, extends from 1941 to 1979. Religious themes inspired his first books ; one may discern a first period when the self evinced dependence from god, producing a mystical speech ; in a second period, rebellion against a god who allowed war became apparent. Then was developed a blasphematory, rebellious discourse. The "militant" output of blas de otero, published from the 1960s, shows man in relation to his kind, and to his times. History and reality are central themes, and the discourse is essentially polemical. He subverts official doctrine and its vision of the past and the present, thus restoring a "heterodox" line of thought. The spanish landscape also becomes alienated from dominant culture. In works often inspired by pictorial art, description is often endowed with symbolic features, and poetry becomes the vehicle of disturbance. Always aimed at the "immense majority", the poetic language incorporated colloquial and oral speech, as as many literary quotations. It tends towards an art of "truthtelling", of transparence, of disapparence of the self

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Hjalmarsson, Anna. "Blås ut! : FMTs betydelse för människans andning." Thesis, Karlstads universitet, Musikhögskolan Ingesund, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-13714.

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Att hantera och kontrollera sin andning är något som de flesta av oss människor gör automatiskt, men ibland kommer vi till stunder då vi behöver ge andningen lite hjälp på traven. Funktionsinriktad MusikTerapi, FMT, kan vara att utmärkt redskap att ta till, när andningstekniken behöver få en skjuts. Andningen kan bearbetas effektivt i FMT på ett lekfullt och avslappnat sätt. Min slutsats är att kroppen behövs för att andningen ska fungera och andningen behövs för att människan ska fungera. FMT behövs!

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Chohra, Chemseddine. "Towards reproducible, accurately rounded and efficient BLAS." Thesis, Perpignan, 2017. http://www.theses.fr/2017PERP0065.

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Le problème de non-reproductibilté numérique surgit dans les calculs parallèles principalement à cause de la non-associativité de l’addition flottante. Les environnements parallèles changent dynamiquement l’ordre des opérations. Par conséquent, les résultats numériques peuvent changer d’une exécution à une autre. Nous garantissons la reproductibilité en étendant autantque possible l’arrondi correct à des séquences de calculs plus importantes que les opérations arithmétique exigées par le standard IEEE-754. Nous introduisons RARE-BLAS une implémentation des BLAS qui est reproductible et précise en utilisant les transformations sans erreur et les algorithmes de sommation appropriés. Nous présentons dans cette thèsedes solutions pour le premier (asum, dot and nrm2) et le deuxième (gemv and trsv) niveaux des BLAS. Nous développons une implémentation de ces solutions qui utilise les interfaces de programmation parallèles (OpenMP et MPI) et les jeu d’instructions vectorielles. Nous comparons l’efficacité de RARE-BLAS à une bibliothèque optimisé (Intel MKL) et à des solutionsreproductibles existantes
Numerical reproducibility failures rise in parallel computation because floating-point summation is non-associative. Massively parallel systems dynamically modify the order of floating-point operations. Hence, numerical results might change from one run to another. We propose to ensure reproducibility by extending as far as possible the IEEE-754 correct rounding property to larger computing sequences. We introduce RARE-BLAS a reproducible and accurate BLAS library that benefits from recent accurate and efficient summation algorithms. Solutions for level 1 (asum, dot and nrm2) and level 2 (gemv and trsv) routines are designed. Implementations relying on parallel programming API (OpenMP, MPI) and SIMD extensions areproposed. Their efficiency is studied compared to optimized library (Intel MKL) and other existing reproducible algorithms

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Johansson, Andreas. "Blos på svenska : Två låtar med Peps Persson." Thesis, Uppsala universitet, Institutionen för musikvetenskap, 1998. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-173898.

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Andreas Johansson: Blos på svenska. Två låtar med Peps Persson. Uppsala: Musikvetenskap, 1998. C-uppsats (60 p). Hur låter amerikansk Chicagoblues framförd av en svensk bluesmusiker? Denna fråga har varit utgångspunkt för uppsatsen, för vilken syftet är att beskriva och jämföra likheter och skillnader mellan dagens Chicagoblues i Sverige och den ursprungliga amerikanska Chicagobluesen från 1950-talet. I uppsatsen jämförs två låtar från Peps Perssons skiva Rotblos (1997) med de låtar Peps använt som förlagor. Jag har valt att analysera låtarnas harmonik, form, ensemblespel, sångstil och text. När en musikgenre flyttas över från en kultur till en annan är ackulturationsprocessen en viktig beståndsdel. I Peps tolkningar är det svårt att hitta spår av någon annan musikform än bluesen. Den största skillnaden mellan förlaga och tolkning finns egentligen i Peps svenska texter. I dessa svenska versioner flyttar Peps låtarnas handling från USA till Skåne, men utan att förlora den ursprungliga innebörden.

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Weemans, Michel. "Les paysages exégétiques et anthropomorphes de Henri Bles." Paris, EHESS, 2004. http://www.theses.fr/2004EHES0147.

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Les études sur les paysages de Bles ont jusqu'à présent mis l'accent exclusivement sur la dimension technique et économique de ces tableaux produits en série par l'atelier de "Bles & Co". Il s'agit ici de reconnaître dans les paysages de Bles une esthétique humaniste de la varietas et une pensée chrétienne dans laquelle l'acte de contemplation de la Création n'est admis que s'il ramène à louer à travers elle son Créateur. L'idée des deux métaphores corollaires et sous-jacentes de livre de la nature et de visio Dei implique notre hypothèse des paysages exégétiques de Bles. Celle-ci, énoncée en termes de "modèle Weltlandschaft et qualificatuer visio Dei" repose sur l'idée de modèle comme instrument heuristique de redescription de la réalité. Elle signifie que les paysages de Bles constituent vis à vis de la nature qu'ils représentent des condensés métaphoriques qui se définissent par leur pouvoir exegétique de transformation au double sens d'une redescription de la réalité décrite et de celui qui perçoit. Enfin, organiser le regard sur les tableaux de Bles autour du paradigme exegétique a rendu possible un "changement d'aspect" : l'apparition dans nombre de paysages de Bles, de crypto-anthropomorphoses. Si ces phénomènes picturaux renvoient à une conception microcosmiste de la Création, ils se définissent dans la peinture exégétique de Bles par leur fonction d'opérateurs de conversion, et rattachent ainsi les oeuvres de ce peintre, aux côtés de celles de Rabelais ou d'Erasme, à la "crise de l'interprétation" qui caractérise la pensée humaniste du seizième siècle
A prevalent approach has considered the landscapes of Henri Bles trough a focaliation on the technical and economical dimension of these paintings mass-produced by the wokshop of "Bles and Co". This project aims instead to recognize in these landscapes a humanist aesthetics of "varietaas" and a christian thought in which the act of beholding the Creation is only admitted insofar as it means to praise its Creator. The idea of the two underlying and corollary metaphors of the Book of nature and visio Dei implies our hypothesis of "exegetical landscape". This hypothesis, formulated in terms of "Welltandschaft model and visio Dei qualifier" is based on the idea of a model as a heuristic tool of redescription of reality. It means that the landscapes of Bles relate to the nature they represent through metaphorical epitomes defined by their exegetical power of transformation in a double meaning : a redescription of the reality described and of the beholder. By organizing the gaze upon Bles' paintings under the exegetical paradigm we have made visible a "changing of aspect" : the apparition of crypto-anthropomorphosis in a great number of Bles' paintings. These pictural phenomenons refer to the microcosmist conception of Creation. In the exegetical painting of Bles they are defined by their function as "conversion operators", and so connect the works of this painter, beside rabelais and Erasmus'ones, to the "crisis of interpretation" caracteristic of the humanist thought of the sixteenth century

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Tatar, Säde. "Blås östanvind / Stilanalysarbete om spilåpiparen Sväs Anders Ersson." Thesis, Kungl. Musikhögskolan, Institutionen för folkmusik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-4222.

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Queiroz, Natália Costa Cimó. "O auge de Nellie Bly." reponame:Repositório Institucional da UFSC, 2013. https://repositorio.ufsc.br/handle/123456789/107052.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Jornalismo, Florianópolis, 2013.
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Esta pesquisa apresenta a análise de 11 reportagens escritas pela jornalista Nellie Bly e publicadas no jornal The New York World entre 1887 e 1889, com o objetivo de recuperar o trabalho desenvolvido por ela e avaliar as possíveis contribuições dessa mulher para a história do jornalismo. A partir das abordagens metodológicas da chamada Nova História, buscou-se contextualizar a análise em relação ao período histórico em que a jornalista se inseria. Os autores Michael Schudson, Frank Luther Mott e George Juergens ofereceram o suporte para a contextualização da história da imprensa nos Estados Unidos. Este trabalho pretende oferecer contribuições para o debate atual acerca de importantes questões para o jornalismo, nomeadamente, o método de apuração e a conceituação de jornalismo investigativo.

Abstract : This research presents the analysis of 11 articles written by the journalist Nellie Bly and published in the New York World between 1887 and 1889, aiming at reviving the work she developed and at evaluating her possible contributions to the history of journalism. Based on methodological approaches provided by the so-called New History, the effort was to contextualize the analysis in relation to the historical period she belonged to. The authors Michael Schudson, Frank Luther Mott and George Juergens provided the basic grounding to rebuild the journalism history in the United States. This work intends to offer contributions to the current debate concerning important issues in journalism, namely, the newsgathering methods and conceptualization of investigative journalism.

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Södergren, Marie, and Kristina Montén. "Jag är inte blyg : SO-lärare talar om sexualitet." Thesis, Örebro University, School of Humanities, Education and Social Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-9085.

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Gomez, Céline. "Etude de la somitogenèse chez le serpent des blés." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2007. http://tel.archives-ouvertes.fr/tel-00807996.

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Le plan d'organisation des vertébrés est caractérisé par la répétition de segments tels que les vertèbres. Les premiers signes de segmentation sont observés pendant l'embryogenèse précoce, lorsque les précurseurs des vertèbres, appelés " somites ", se forment de manière périodique à partir du mésoderme paraxial présomitique (PSM). Il a été proposé qu'une "horloge de segmentation" contrôlerait la périodicité de formation des somites en interagissant avec un "front de détermination" reculant caudalement dans le PSM. Afin de comprendre les mécanismes établissant le nombre total de somites chez les vertébrés, j'ai comparé la régulation de la somitogenèse dans une espèce en formant un grand nombre-le serpent des blés- avec la souris, le poulet et le poisson zèbre. J'ai premièrement cloné et analysé par hybridation in situ l'expression des gènes impliqués dans la formation de front de détermination et de l'horloge de segmentation. Le patron d'expression des gènes associés au front s'est révélé conservé, alors que celui de lunatic fringe, un gène associé à l'horloge, s'est révélé particulièrement atypique. Une étude comparative basée sur un modèle mathématique nous a conduit à l'hypothèse que ce patron d'expression traduisait un rythme accéléré de l'horloge par rapport à la vitesse d'élongation de l'axe chez le serpent, expliquant ainsi sa production accrue de somites. En conclusion, notre étude, conduite sur un modèle original, suggère que la relation entre horloge et croissance de l'axe est un facteur important pour expliquer la différence du nombre de somites entre vertébrés.

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Saez, Diaz Sergio Andres. "La ocupación del sitio de San Blas, Óndores - Junín." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2019. https://hdl.handle.net/20.500.12672/10545.

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Identifica a partir de excavaciones la presencia de moldes cerámicos para la elaboración de panes de sal, además de la ausencia de estructuras de habitación. Estas evidencias contradicen la propuesta inicial de la presencia de colonos asentados en el sitio e indican que la población de la región desarrolló una tecnología para la explotación especializada de la sal. Todo ello habla de un comportamiento más dinámico de la población; no es que recibían a colonos para que explotasen un recurso valioso de sus tierras, sino que ellos mismos se encargaron de la distribución de la sal, desde el Periodo Formativo (durante el cual se inventó la tecnología) hasta la época inka, pudiendo establecer una red de intercambio que incluyó los actuales departamentos de Áncash, Huánuco, Pasco, Junín e, incluso, Huancavelica.
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Tatar, Säde. "Säde Tatar examensarbete BLÅS ÖSTANVIND : Spilåpipare Sväs Anders Ersson." Thesis, Kungl. Musikhögskolan, Institutionen för folkmusik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-4196.

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Konserten ägde plats 4 juni kl 19 i Lilla salen, KMH. Blev livestreamad via KMHs Youtubekanal.

1. Sövlåten efter Nygårds Karin Persson från Öje, Dalarna (Säde Tatar - svensk säckpipa)2. Suomela gånglåt Musik: Säde Tatar (Säde Tatar - svensk säckpipa, Vega Nordkvist – fiol, Coline Genet – fiol, Gabbi Dluzewski – låtmandola) F#-mollpolskan Musik: Säde Tatar Arr: Säde Tatar & Gabbi Dluzewski (Säde Tatar - Åspipa, Gabbi Dluzewski – låtmandola) 3. Tulvil Musik & arr: Säde Tatar & Gabbi Dluzewski (Säde Tatar - tvärflöjt, Gabbi Dluzewski – låtmandola 4. Jouhikkolåtar efter Feodor Pratsu från Impilahti, Karelen (Säde Tatar - sälgflöjt)5. Krångelpolska efter Ol ́Jansa och Andreas Lång, Haverö Komposition: Göran Månsson (Säde Tatar - tvärflöjt) 6. Halia soitto efter Natalia Vassili, Ingermanland (Säde Tatar - Åspipa)7. Tantsukollena efter Natalia Vassili, Ingermanland (Säde Tatar - Åspipa, Göran Månsson – spelpipa)8. Kratitöö Musik: Säde Tatar (Säde Tatar - Härjedalspipa, Vega Nordkvist – fiol, Coline Genet – fiol, Göran Månsson – härjedalspipa, Gabbi Dluzewski – låtmandola)9. Rabatud Musik: Säde TatarArr: FRÄNDER (Säde Tatar - altflöjt, Daniel Dluzewski – kontrabas, Alva Granstörm – fiol, Andreas Berglund – slagverk, Gabbi Dluzewski – låtmandola 10. Õhtu õrna Musik: Säde Tatar Text: estnisk trad. från Viru-Jaagupi Arr: FRÄNDER (Säde Tatar - sång, tvärflöjt, Daniel Dluzewski – kontrabas, Alva Granstörm – fiol, Andreas Berglund – slagverk, Gabbi Dluzewski – låtmandola)11. Kung Björns polska Musik: Gabbi Dluzewski Arr: FRÄNDER (Säde Tatar - mungiga, tvärflöjt, Daniel Dluzewski – kontrabas, Alva Granstörm – fiol, Andreas Berglund – slagverk, Gabbi Dluzewski – låtmandola)12. Evigt regn Musik: Gabbi Dluzewski Text: Natasja Dluzewska Arr: FRÄNDER (Säde Tatar -- tvärflöjt, Daniel Dluzewski – kontrabas, Alva Granstörm – fiol, Andreas Berglund – slagverk, Gabbi Dluzewski – låtmandola)

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Jesus, Carlos Gustavo Nóbrega de [UNESP]. "Revista Gil Blas e o nacionalismo de combate (1919-1923)." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/103134.

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Made available in DSpace on 2014-06-11T19:32:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-03-18Bitstream added on 2014-06-13T20:03:51Z : No. of bitstreams: 1 jesus_cgn_dr_assis_parcial.pdf: 72742 bytes, checksum: 615bcf5018f8ecaa6066385c6d483bff (MD5) Bitstreams deleted on 2015-02-09T17:15:03Z: jesus_cgn_dr_assis_parcial.pdf,Bitstream added on 2015-02-09T17:15:40Z : No. of bitstreams: 1 000649923.pdf: 4860627 bytes, checksum: 2cf2b7387e859434937acabd2f39f1d5 (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Gil Blas surgiu na cidade do Rio de Janeiro, em 13 de fevereiro de 1919 e circulou até 6 de maio de 1923. A publicação foi porta voz do governo Epitácio Pessoa (1919-1923) e esteio de concepções nacionalistas da década de 1920, fato que a torna fonte relevante para se entender o panorama político e cultural do Brasil daquele momento. Deve-se destacar que, em mais de quatro anos de existência, o periódico teve várias fases, nas quais abraçou propostas nacionalistas diversas, imprimiu caráter dinâmico aos seus objetivos, seções, artigos e mesmo materialidade. O propósito da pesquisa foi o de demarcar tais mudanças, distinguir os projetos defendidos nas suas páginas, além de explicar que tais alterações estavam em consonância com o envolvimento político e doutrinário da revista.
Gil Blas appeared in the city of Rio de Janeiro, in 13 of February of 1919, having circulated up to 6 of May of 1923. Such publication if constituted in door voice of the Epitácio Pessoa Government (1919-1923) and support of nationalistic conceptions of the decade of 1920, fact that became it an excellent source to understand the panorama cultural politician and of Brazil of this moment. It must be detached that, in more than four years of publication, the periodic one had some phases that if had articulated with diverse nationalistic proposals, what it gave a dynamic character to its objectives, sections, articles and materiality. The intention of this research was to demarcate such changes, as well as the nature of the proposals that had appeared in the interior of the periodic one, showing that such alterations were in accord with the initiatives doctrinal politics of the magazine.

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Jesus, Carlos Gustavo Nóbrega de. "Revista Gil Blas e o nacionalismo de combate (1919-1923) /." Assis : [s.n.], 2011. http://hdl.handle.net/11449/103134.

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Orientador: Tânia Regina de Luca
Banca: Sílvia Maria Azevedo
Banca: Marly Silva da Motta
Banca: Raimundo Pereira Alencar Arrais
Banca: Zelia Lopes da Silva
Resumo: Gil Blas surgiu na cidade do Rio de Janeiro, em 13 de fevereiro de 1919 e circulou até 6 de maio de 1923. A publicação foi porta voz do governo Epitácio Pessoa (1919-1923) e esteio de concepções nacionalistas da década de 1920, fato que a torna fonte relevante para se entender o panorama político e cultural do Brasil daquele momento. Deve-se destacar que, em mais de quatro anos de existência, o periódico teve várias fases, nas quais abraçou propostas nacionalistas diversas, imprimiu caráter dinâmico aos seus objetivos, seções, artigos e mesmo materialidade. O propósito da pesquisa foi o de demarcar tais mudanças, distinguir os projetos defendidos nas suas páginas, além de explicar que tais alterações estavam em consonância com o envolvimento político e doutrinário da revista.
Abstract: Gil Blas appeared in the city of Rio de Janeiro, in 13 of February of 1919, having circulated up to 6 of May of 1923. Such publication if constituted in door voice of the Epitácio Pessoa Government (1919-1923) and support of nationalistic conceptions of the decade of 1920, fact that became it an excellent source to understand the panorama cultural politician and of Brazil of this moment. It must be detached that, in more than four years of publication, the periodic one had some phases that if had articulated with diverse nationalistic proposals, what it gave a dynamic character to its objectives, sections, articles and materiality. The intention of this research was to demarcate such changes, as well as the nature of the proposals that had appeared in the interior of the periodic one, showing that such alterations were in accord with the initiatives doctrinal politics of the magazine.
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Sánchez, García María Belén. "La contribución de Blas María Colomer a la pedagogía pianística." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/90525.

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The present thesis involves a study on the figure of Blas Maria Colomer, a Valencian pianist and composer, and the contribution of his piano method to pianistic pedagogy. Colomer began his musical studies in Valencia and moved to Paris in his youth to complete them. There he settled down and remained until the end of his days, developing a broad activity in the three aspects mentioned, concert, compositional and pedagogical. In this way, the study is structured in three chapters that respond to as many fields of study: In the first chapter we have developed Colomer's biographical profile. We have collected his biographical data and defined it in his historical and social context. In the second section, an inventory of his works has been made, analyzing the distribution of the same ones within the production. We have also tried to situate the compositional work in the historical and social context of the author. In the third chapter we have proceeded to analyze the piano method École Nouvelle and his supplement Nouveaux Exercises, appropriate for the first level of initiation to the study of piano, from an analytical perspective of the pianistic writing and the technique of movements. Taking into account the research carried out we can affirm that Colomer's method responds to didactic and technological conceptions of pianistic pedagogy of the late nineteenth and early twentieth century; what distinguishes his didactic is essentially the application of the melody as the backbone of the learning process, away from traditional methodological textbooks. With the developed research we hope to contribute to the recovery of Blas Maria Colomer as a pianist, composer and pedagogue, after being relegated to oblivion for a long time.
La presente Tesis supone un estudio sobre la figura de Blas María Colomer, pianista y compositor valenciano, y la contribución de su método de piano a la pedagogía pianística. Colomer comenzó sus estudios musicales en Valencia y se trasladó a París en época de juventud para completarlos. Allí se afincó y permaneció hasta el final de sus días, desarrollando una amplia actividad en las tres vertientes nombradas, la concertística, la compositiva y la pedagógica. De este modo, el trabajo está estructurado en tres capítulos que responden a otros tantos campos de estudio: En el primero se ha desarrollado el perfil biográfico. Se ha procedido a recopilar sus datos biográficos y enmarcarlos en su contexto histórico-social. En el segundo se ha procedido a confeccionar un inventario de sus obras, analizando además la distribución de las mismas dentro de la producción. También hemos tratado de situar la obra compositiva en el contexto histórico-social del autor. En el tercer capítulo hemos procedido a analizar el método de piano École Nouvelle y su suplemento Nouveaux Exercises, apropiado para el primer nivel de iniciación al estudio del piano, desde una perspectiva analítica de la escritura pianística y la técnica de movimientos. A la vista de la investigación llevada a cabo podemos afirmar que el método de Colomer responde a las concepciones didácticas y tecnológicas de la pedagogía pianística de finales del siglo XIX y principios del XX; lo que distingue su didáctica es en esencia la aplicación de la melodía como eje vertebrador del proceso de aprendizaje y se aleja de los tradicionales compendios metodológicos. Con la investigación realizada esperamos contribuir a la recuperación de Blas María Colomer como pianista, compositor y pedagogo, durante mucho tiempo relegado al olvido.
La present Tesi suposa un estudi sobre la figura de Blas María Colomer, pianista i compositor valencià, i la contribució del seu mètode de piano a la pedagogia pianística. Colomer va començar els seus estudis musicals a València i es va traslladar a París en època de joventut per a completar-los. Allí es va establir i va romandre fins al final dels seus dies, desenrotllant una àmplia activitat en les tres vessants anomenades, la concertística, la compositiva i la pedagògica. D'esta manera, el treball està estructurat en tres capítols que responen a altres tants camps d'estudi: En el primer s'ha desenrotllat el perfil biogràfic. S'ha procedit a recopilar les seues dades biogràfiques i emmarcar-les en el seu context historicosocial. En el segon s'ha procedit a confeccionar un inventari de les seues obres, analitzant-ne a més la seua distribució dins de la producció. També hem tractat de situar l'obra compositiva en el context historicosocial de l'autor. En el tercer capítol hem procedit a analitzar el mètode de piano École Nouvelle i el seu suplement Nouveaux Exercises, apropiat per al primer nivell d'iniciació a l'estudi del piano, des d'una perspectiva analítica de l'escriptura pianística i la tècnica de moviments. A la vista de la investigació duta a terme podem afirmar que el mètode de Colomer respon a les concepcions didàctiques i tecnològiques de la pedagogia pianística de finals del segle XIX i principis del XX; allò que distingeix la seua didàctica és en essència l'aplicació de la melodia com a eix vertebrador del procés d'aprenentatge i s'allunya dels tradicionals compendis metodològics. Amb la investigació realitzada esperem contribuir a la recuperació de Blas María Colomer com a pianista, compositor i pedagog, durant molt de temps relegat a l'oblit.
Sánchez García, MB. (2017). La contribución de Blas María Colomer a la pedagogía pianística [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/90525
TESIS

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Hauge, John Hutcheson Drew Scott Paul. "Boundary layer data system (BLDS) heating system : final project report /." Click here to view, 2009. http://digitalcommons.calpoly.edu/mesp/2/.

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Jauler, Doria-Medina María Jesús. "Yo soy artista y artesano: la distinción en un espacio de producción cultural de San Blas, Cusco." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2014. http://tesis.pucp.edu.pe/repositorio/handle/123456789/5938.

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La primera vez que visité San Blas fue en el año 2007. Fui con mi promoción del colegio. Con el único ánimo de conocer, compré algunos souvenirs en la feria artesanal del barrio, paseé por sus calles y observé con fascinación sus hermosos balcones azules. No podía faltar también, la típica foto con toda la promoción bajo la paqcha de la plaza. ―Quería volver. No. Tenía que volver‖ ––me dije a mí misma––. Tal fue mi admiración por el Cusco que mi primer trabajo académico en la universidad fue sobre la región y su relación con el turismo. Recuerdo que fue para el curso de ―Argumentación‖. Este, sería mi primer acercamiento a mucha de la bibliografía de esta tesis. Digamos pues, que el Cusco acompañó mis rutas como estudiante desde que salí del colegio.
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Lehn, Michael Christian. "FLENS - A Flexible Library for Efficient Numerical Solutions." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-64199.

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Boccardo, Raphael. "Deus das ruínas: a poética da insuficiência de Blas de Otero." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/8/8145/tde-15022019-140046/.

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Esta dissertação analisa seis poemas de duas das obras mais importantes do poeta Blas de Otero, Ángel fieramente humano (1949) e Redoble de conciencia (1950), com o objetivo de fornecer uma interpretação que busque unir três elementos fundamentais para o entendimento de sua poética: sua biografia, o contexto histórico do Pós-Guerra Civil Espanhola e os elementos existencialistas que se conformam em seus sonetos. O trabalho entrelaça, portanto, a conjuntura histórico-social dos anos de 1940, ou seja, o período imediato após o término da Guerra Civil e o estabelecimento da ditadura franquista, com os rumos pessoais do poeta basco Blas de Otero que gerará, em 1949 e 1950, as duas obras consideradas parte de sua fase existencialista. A partir dessas perspectivas, o debate proposto visa propiciar uma nova visão que possa unir o social com o existencial, o histórico com o poético, o individual com o universal, integrando assim as diferentes percepções da crítica da obra do poeta em uma interpretação orgânica para o que denominamos de poética da insuficiência de Blas de Otero.
This dissertation analyzes six poems of two of the most important works of the poet Blas de Otero, Ángel fieramente humano (1949) and Redoble de conciencia (1950), with the aim of providing an interpretation that seeks to unite three fundamental elements for the understanding of his poetics: his biography, the historical context of the Spanish Civil War and the existentialist elements that conform to his sonnets. The work thus interweaves the historical-social conjuncture of the 1940s, that is, the immediate period after the end of the Civil War and the establishment of the Franco dictatorship, with the personal directions of the Basque poet Blas de Otero, which will generate, in 1949 and 1950, the two works considered part of their existentialist phase. From these perspectives, the proposed debate aims to provide a new vision that can integrate the social with the existential, the historical with the poetic, the individual with the universal, integrating the different perceptions of the critique of the poet\'s work in an organic interpretation for what we call the poetics of Blas de Otero\'s insufficiency.

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Barraza, Lescano Sergio. "Un lector desconocido del jesuita Blas Valera : Francisco de Herrera Maldonado." Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/114486.

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Jualer, Doria-Medina María Jesús. "Entre lo global y lo local: San Blas, un barrio heterogéneo." La Colmena, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/91683.

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Este artículo surge a partir de mi tesis de licenciatura titulada "Yo soy artista y artesano. La distinción en un espacio de producción cultural de San Blas, Cusco". En él buscamos evidenciar y reflexionar en torno a las principales connotaciones que se le atribuyen al barrio de San Blas en el contexto actual del boom turístico que se produce en el Cusco. En ese sentido, identificamos, a lo largo del texto, las principales características que hacen de San Blas un espacio local en tensión en donde algunos de sus elementos se pierden o transforman en función al turismo masivo. San Blas es históricamente conocido en el Cusco por ser el "barrio de los artistas y artesanos". Con el paulatino aumento del turismo, sin embargo, el lugar se ganó también la denominación de "barrio turístico". ¿Cómo entender este San Blas turístico y tradicional? Sostenemos que el barrio es un espacio heterogéneo en donde los contenidos de su cultura local se encuentran en disputa. Siguiendo a Vich (2001), se trata de un lugar en donde el encuentro cultural está marcado por relaciones de poder violentas que están llevando a la pérdida y reconfiguración de lo "sanbleño".

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Eriksson, Per. "Discriminación hacia los aymaras en el caso jurídico chileno de Gabriela Blas." Thesis, Umeå universitet, Institutionen för språkstudier, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122891.

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Abstrakt Denna studie försöker ta reda på om chilenska domar genom sitt språk leder till att tillgängligheten till rättsväsendet försvåras. Detta görs genom att studera ett omdebatterat fall i Chile där Gabriela Blas döms till 12 års fängelse för att lämna kvar sitt barn på den andinska högplatån vilket ledde till att barnet dig hon gjorde detta utifrån aymaraindianernas traditionella kultur och sedvänjor. För att studera dessa frågeställningar används trianguleringsmetoden i form av att använda olika metoder och olika teorier för att studera fallet med aymaraherdinnan. Kvantitativ metod används för att mäta antalet långa meningar och längden på dessa meningar. Den kvalitativa metoden utgår från kritisk diskursanalys där makrostrukturer och lokala betydelser identifieras. Teoribildningen består av kapitel om myndighetsspråk, diskrimination och intersektionalitet och aymaraindianernas kultur och historia. Samtliga domar har långa meningar och meningar som är mycket långa. Speciellt domarna i första instans utmärker sig både gällande att stort antal långa meningar och extremt långa meningar. Gällande texter med diskriminerande innehåll existerar dessa endast i domarna i första instans och då är det fråga om intersektionalitet.
Resumen Este estudio se ocupa de estudiar si el uso del idioma en las sentencias chilenas dificulta el acceso a la justicia. Esto se realiza mediante el análisis de un caso polémico en Chile en que Gabriela Blas fue condenada a 12 años de presidio por abandonar a su hijo en el altiplano andino con resultado de muerte, lo que hacía según las costumbres y cultura de los aymaras. Para responder estas preguntas se usa el método de triangulación y diferentes teorías para estudiar el caso con Gabriela Blas. Se usa el método cuantitativo para medir la cantidad de frases largas y la longitud de estas frases. El método cualitativo parte del Análisis Crítico del Discurso donde se define macroestructuras y significados locales. El marco teórico consta de capítulos sobre lenguaje administrativo/jurídico, discriminación e interseccionalidad y la cultura e historia de los aymara. Todas las sentencias tienen frases largas y frases muy largas, en particular, las sentencias de la primera instancia, que además, son las únicas que utilizan escritura discriminatoria y allí se habla de la interseccionalidad.

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Davetian, Benet. "Reconsidering the siblings : a critical study of Robert Bly's The Sibling Society." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0005/MQ39450.pdf.

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Joubert, Marianne. "Adéquation des blés durs aux opérations de transformations technologiques : semoulerie et pastification." Thesis, Montpellier, SupAgro, 2017. http://www.theses.fr/2017NSAM0045.

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Le blé dur est la matière première de base pour la production de semoules et de pâtes. Les origines des rendements semouliers et qualité des pâtes sont multifactorielles. Or, il n’existe pas aujourd’hui d’outil global permettant de prédire les valeurs semoulières et pastières des blés durs sur la base des caractéristiques physiques et biochimiques des grains. Le travail mené dans le cadre de cette thèse s’attache à objectiver le potentiel semoulier et pastier de lots de grains, issus de pratiques culturales innovantes, dans une optique d’améliorer la durabilité de la filière blé dur.Des lots de grains de blé dur ont été caractérisés et leurs variabilités mises en relation avec les différents itinéraires techniques agricoles dont ils sont issus. L’impact de la qualité des récoltes sur le comportement à la mouture des lots, ainsi que sur l’aspect des pâtes sèches et la texture des pâtes cuites a été étudié. Les teneurs en protéines, en cendres et la granulométrie de la semoule ont été identifiées comme des facteurs influençant la qualité des pâtes. Une démarche « plan d’expériences » a été développée pour évaluer l’impact d’un seul facteur, indépendamment des deux autres, sur la qualité des pâtes. L’efficience des procédés de transformation en fonction de la variabilité de la matière première a également été appréciée. En particulier, l’impact des caractéristiques des grains de blé dur sur les énergies nécessaires à la mouture, les liens entre composition de la semoule et comportement à l’extrusion et l’efficacité de différents diagrammes de séchage sur la qualité des pâtes en fonction de leurs compositions, ont été analysés. Une étude a été également menée sur l’état de polymérisation des protéines au cours de la fabrication des pâtes. Enfin, cette thèse a permis la constitution d’une base de données qui contribuera à la prédiction de la qualité des semoules et pâtes en fonctions des caractéristiques physiques et biochimiques des blés durs
Durum wheat is the best raw material to process semolina and pasta. The origins of high semolina yield and the good pasta quality are multifactorial. However, there is currently no tool predicting milling and pasta making results based on physical and biochemical characteristics of durum wheat grains. The work carried out in this PhD thesis attempts to objectify the technological value of durum wheat samples, grown with innovative technical practices in order to improve sustainability of the French durum wheat chain.Durum wheat samples batches were characterised and their variability was related to the different agricultural technical routes used. The impact of the grain quality on the milling behaviour of the samples, as well as the appearance of the dry pasta and the texture of the cooked pasta was studied. Protein, ash contents and semolina particle size distribution were identified as factors influencing pasta quality. An “experimental design” approach was developed to obtain a non-distorted estimate of how each variable impacts the quality of pasta, independently of the other two variables. Efficiency of the semolina milling and pasta making processes depending on the variability of the raw material was also assessed. Especially, the impact of durum wheat grains characteristics on the energies required for milling, the relationship between semolina composition and extrusion behaviour and the effectiveness of different drying diagrams on the quality of the pasta based on their compositions were analysed. A study on the protein polymerisation state during the pasta making process was also conducted. Finally, this PhD thesis has contributed to the development of a database that will predict semolina and pasta quality depending on physical and biochemical characteristics of durum wheat

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35

Virion, Marie-Christine. "Méthodologies statistiques de la discrimination : application aux électrophorégrammes des farines de blés." Montpellier 2, 1988. http://www.theses.fr/1988MON20229.

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On presente un travail de synthese sur la theorie des clefs d'identification, qui regroupe et etend certains resultats connus. En particulier, le theoreme de shannon a ete redemontre, et le contexte mathematique de brown generalise. Des generalisations des methodes factorielles ont ete etudiees. (acp, analyse discriminante). Quelques resultats de convergence ont ete etudies, et particularises pour analyser des courbes continues, echantillonnees, et leurs series de fourier. Des electrophoregrammes de farines de bles ont ete analyses avec ces methodes

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36

Chalabi, Smahane. "Caractérisation de la reprogrammation de l'expression des gènes chez les blés allopyloïdes." Thesis, Evry-Val d'Essonne, 2014. http://www.theses.fr/2014EVRY0040.

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La polyploïdie ou la duplication des génomes est une force majeure dans l'évolution et l'adaptation des espèces, notamment des angiospermes qui ont tous eu des évènements de polyploïdisation réccurrents au cours de leur évolution. Afin de comprendre la reprogrammation de l'expression des gènes en réponse à la polyploïdie chez les espèces économiquement importantes du blé (genres Triticum et Aegilops), j'ai utilisé un modèle original, qui consiste à caractériser les réponses à la diminution puis la ré-augmentation du niveau de ploïdie. Ainsi, le blé allotétraploïde (T. turgidum, BBAA) est extrait à partir du blé naturel allohexaploïde (T. aestivum, BBAADD). Ce blé allotétraploïde extrait est hybridé à son tour à l'espèce diploïde Ae. tauschii (DD) pour synthétiser un blé allohexaploïde.J'ai utilisé des méthodes d'analyse de l'expression des gènes basées sur les microarrays ainsi que le séquençage massif des ARN (RNA-Seq), basé sur les outils de nouvelles générations de séquençage (NGS) et rendu possible par la récente mise à disposition des séquences de trois copies homéologues (Ah, Bh, Dh) de 8605 gènes. Les méthodes bioinformatiques et statistiques appropriées ont été développées et/ou utilisées.Mes travaux révèlent un partitionnement de l'expression des gènes en celles des homéologues qui les composent dans les différents allopolyploïdes étudiés. La majorité des homéologues contribuent à l'expression globale des gènes de manière équivalente (1/3 chacun), d'autres présentent un biais d'expression spécifique vers un des homéologues, sans montrer de dominance d'un des sous-génomes. Une concertation dans le partitionnement et le niveau d'expression des homéologues est bien établie dans le blé: la majorité des homéologues augmentent leur expression lorsqu'ils sont séparés et la diminuent lorsqu'ils sont rassemblés dans un niveau de ploïdie supérieur. Ainsi, dans le blé allohexaploïde, pour la majorité des gènes, l'expression des homéologues Ah et Bh est égale au 2/3 de leur niveau d'expression dans le blé allotétraploïde extrait, et l'expression de l'homéoallèle Dh est égale au 1/3 du niveau d'expression dans le blé diploïde donneur du génome D. Cette concertation de l'expression des homéologues maintiendrait l'expression globale des gènes à des niveaux similaires dans les différentes espèces de blé de différents niveaux de ploïdie.Les résultats obtenus contribuent à la compréhension de la régulation de l'expression des gènes dans les polyploïdes du blé et la contribution des homéologues qui les composent. Les analyses futures des fonctions des différentes catégories d'expression des gènes permettraient d'identifier des fonctions particulières régulées en réponse à la polyploïdie
Polyploidy is a major evolutionary force, especially in angiosperms, all of which species have undergone recurrent polyploidization events during their evolution.In order to understand reprogramming of gene expression in response to polyploidy in the economically important wheat species (genera Triticum and Aegilops), I used an original model that consists in decreasing and reincreasing ploidy levels. Thus, the allotetraploid T. turgidum (BBAA) is extracted from the allohexaploid bread wheat T. aestivum (BBAADD), consisting in decreasing ploidy level. This extracted allotetraploid is crossed with the diploid species Ae. tauschii (DD) to synthesize an allohexaploid wheat, consisting in re-increasing ploidy level.The characterization of reprogramming of gene expression in response to decreasing and re-increasing ploidy levels was done here using first microarray technologies and then massive parallel mRNA sequencing (RNA-Seq), that has been rendered possible by the recent ‘draft' hexaploid wheat genome sequencing and subsequently the availability of the three homoeologs sequences (Ah, Bh, Dh) of 8605 genes. Adequate bioinformatics and statistics methods have been adopted and/or developed and used.My work reveals a partitioning of global expression of genes into that of their constituent homoeologs in different wheats allopolyploids. Most of homoeologs contribute equally to the overall gene expression and a low proportion reveals a bias towards one homoeolog, without showing a global dominance of a specific sub-genome. The partitioning and concerted expression of homoeologs is also established in wheat. Most homoeologs increase their expression when separated and reduce their expression levels when joined together in a higher ploidy level. For most genes, Ah and Bh homoeolog expression in allohexaploid wheat is equal to 2/3 of their expression level in the extracted allotetraploid wheat whereas the Dh homoeolog expression level is equal to 1/3 of that in the wheat diploid genome. This concerted change in homoeolog expression maintains the global gene expression at nearly similar levels in different ploidy levels.Results obtained in this work contribute to our understanding of global gene expression regulation and its partitioning between constituent homoeologs at different ploidy levels. Functional analysis of the different gene expression categories would reveal important gene functional categories that are regulated in response to polyploidy

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37

Smith, Christine. "The development and validation of the Breast Lymphoedema Severity Symptom (BLYSS) questionnaire." Thesis, Curtin University, 2013. http://hdl.handle.net/20.500.11937/1022.

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The emergence of breast conservation therapy, with reported increased rates of breast lymphoedema encouraged this study. Using a standardised approach and utilising an extensive literature review and key informants including clinical specialists and patients with breast lymphoedema, the BLYSS questionnaire was developed. Through an iterative process, the validity and reliability of the BLYSS questionnaire was established. In addition, a definition for breast lymphoedema was developed using a consensus approach and applied in the study.

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38

Grimberg, Olsson Sara, and Caroline Fredriksson. "Kommunikationsängsliga elever i undervisningen : Elevers upplevelser och lärares förhållningssätt." Thesis, Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-28765.

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Syftet med vår kunskapsöversikt har varit att belysa den problematik som kan uppstå när kommunikationsängsliga elever förväntas delta muntligt i undervisningen. Vi har använt oss av metoderna databassökning och manuell sökning vilket har resulterat i sju vetenskapliga texter. Dessa texter har utgjort resultatet av vår kunskapsöversikt. Resultatet har visat att kommunikationsängsliga elever känner obehag inför att delta muntligt och orsaken till detta har visat sig vara oro och rädsla för att göra bort sig och hånas av sina klasskamrater. Resultatet har också visat att lärare har olika förhållningssätt till kommunikationsängsliga elever och att detta i många gånger grundar sig i lärares egna tidigare erfarenheter som kommunikationsängsliga elever. Fortsatt forskning skulle kunna undersöka om lärare prioriterar elevers muntliga deltagande eller elevers välmående i undervisningen. Även lärares strategier och metoder skulle kunna undersökas samt vilket resultat de får för kommunikationsängsliga elevers lärande och välmående.

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39

Leite, Juliana Abigail. "Bacillus cereus produtor de substâncias semelhantes a bacteriocinas (BLIS): isolamento, caracterização preliminar e aplicação de extrato semi-purificado contendo BLIS para inibição de Listeria monocytogenes em polpa de fruta." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-25022013-092146/.

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Mudanças nos hábitos alimentares dos consumidores têm aumentado a demanda por frutas frescas e polpas de frutas. Com isso, a busca por novos compostos com atividade antimicrobiana é de grande interesse, já que a aplicação de aditivos químicos convencionais em alimentos tem sido reavaliada devido à potencial toxicidade de alguns desses compostos. As bacteriocinas ou BLIS, produzidas por diferentes gêneros bacterianos, têm despertado grande interesse industrial para aplicação em alimentos em processos de bioconservação. No presente trabalho, foram obtidos 3 isolados bacterianos (A, B e C) a partir de polpa de abacaxi, produtores de substância antagonista frente a diferentes linhagens de Listeria monocytogenes e Bacillus sp. A natureza proteica das substâncias antagônicas produzidas pelos isolados foi confirmada pela sensibilidade à enzima ? - quimotripsina. As linhagens foram identificadas através de provas bioquímicas e moleculares como Bacillus cereus, com a colaboração da Fundação Oswaldo Cruz (Rio de Janeiro, Brasil). Para estudos mais detalhados da BLIS foi selecionado o isolado C denominado Bacillus cereus LFB-FIOCRUZ 1640. A melhor condição de incubação para produção da BLIS foi a 30ºC/24 horas, em caldo MRS. A BLIS apresentou estabilidade térmica por até 30 minutos a 80ºC e em ampla faixa de pH frente a L. monocytogenes. A purificação da BLIS foi realizada com resina Amberlite XAD-16 e de troca catiônica SP-Sepharose \"Fast Flow\", tendo o extrato apresentado um fator de purificação de 4,1 vezes e rendimento de 30%. O extrato obtido foi liofilizado e uma alíquota foi analisada por SDS-PAGE, o que permitiu a estimativa da massa molecular da BLIS de 25 kDa. A Concentração Bactericida Mínima (CBM) de 2 mg/mL foi determinada frente ao indicador L. monocytogenes e esta concentração de extrato foi aplicada em sistema modelo contendo polpa de abacaxi. A BLIS teve ação bactericida inibindo completamente L. monocytogenes por 24h/ 37ºC. Neste sentido, a aplicação da BLIS na área de alimentos e outras áreas farmacêuticas poderá ser explorada em outros trabalhos.
Changes in habits of consumers, with preference for healthy foods, have increased the demand for fruits and fruit pulps. Thus, there is great interest in searching new compounds with antimicrobial activity, since the application of conventional additives in foods is of concern due to the toxicity of some of these compounds. The bacteriocins or BLIS, produced by different bacteria genera, have increased the interest for its industrial application in food technology in processes of biopreservation. In this study, three isolates were obtained (A, B and C) from pineapple pulp, which produce antagonistic substances with activity against Listeria monocytogenes and Bacillus sp. The proteinaceous nature of the antagonistic substance produced by the isolates was confirmed by susceptibility to the enzyme ? - chymotrypsin. The strains were identified by biochemical and molecular tests as Bacillus cereus, in collaboration with Fundação Oswaldo Cruz (Rio de Janeiro, Brazil). Isolate C of Bacillus cereus was named LFB-FIOCRUZ 1640. The best condition of incubation for the BLIS production was 30°C for 24 hours in MRS broth. The BLIS was thermostable (up to 30 minutes at 80°C) and it was partially stable in the range of pH 2 to 9. The purification of the BLIS was performed with Amberllite XAD-16 and cation-exchange SP-Sepharose \"Fast Flow\" resins. The extract presented a purification factor of 4.1 times and 30% of yield. The extract was lyophilized and analyzed by SDS-PAGE. The molecular mass of the BLIS was estimated as 25 kDa. The Minimum Bactericidal Concentration (MBC) of 2 mg/mL was determined with the indicator L. monocytogenes, and this concentration of extract was applied in a model system containing pineapple pulp. The BLIS had bactericidal action which completely inhibited L. monocytogenes for 24h/37°C. The BLIS of B. cereus 1640 presents potential for application as an antimicrobial in food and other pharmaceutical areas.

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40

Martini, Gisela de Assis. "Investigação da atividade estrogênica e de interferentes endócrinos em águas superficiais do Estado de São Paulo." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-28082018-161427/.

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Nas últimas décadas, a ocorrência de atividade estrogênica e interferentes endócrinos (IEs) no ambiente aquático têm se tornado uma crescente preocupação. Dentre as diversas substâncias classificadas como IEs, destacam-se os fármacos, produtos de higiene e cuidados pessoais, hormônios naturais e sintéticos, produtos químicos industriais, praguicidas e muitos outros compostos que atingem o ambiente aquático por meio de descargas de esgoto doméstico, industrial ou de escoamento agrícola. Os objetivos deste estudo foram determinar a atividade estrogênica em amostras de águas superficiais, e avaliar seus efeitos biológicos no desenvolvimento de embriões de Danio rerio, a fim de propor faixas baseadas em valores de desencadeamento de efeitos para categorizar a atividade estrogênica. As amostras ambientais também foram analisadas por cromatografia líquida acoplada com a espectrometria de massas para identificar as substâncias que são suspeitas de causar alteração endócrina. Os compostos analisados foram: praguicidas, hormônios, triclosan, bisfenol A, octilfenol, nonilfenol, e a cafeína como indicador de atividade antrópica. A atividade estrogênica foi medida pelo ensaio Bioluminescent Yeast Estrogen (BLYES), que fornece os resultados em equivalente de 17β-estradiol (EEQ). No entanto, este ensaio não é capaz de prover informações sobre os efeitos adversos em organismos aquáticos. Para observação de possíveis efeitos na biota, os embriões foram expostos a amostras de águas superficiais com resultados acima de 0,1 EEQ no BLYES. Os ensaios foram realizados de acordo com a OECD No. 236 (2013), verificando efeitos agudos como: ausência de batimento cardíaco, não formação de somitos, não desprendimento da cauda, e embrião coagulado. Malformações embrionárias tais como: redução do tamanho do organismo, edema cardíaco e vitelínico, curvatura da coluna vertebral, também foram avaliadas. As informações obtidas pelo ensaio com embriões de Danio rerio foram adequadas para mostrar os efeitos da mistura de contaminantes em organismos não-alvo. A atividade estrogênica medida pelo BLYES ficou abaixo do limite de quantificação (0,1 EEQ) em 44,8% do total de 116 amostras analisadas, e a faixa de atividade estrogênica variou de 0,11 a 14,6 EEQ. Além disso, a presença de contaminantes mesmo que em concentrações baixas ressalta a necessidade de mais estudos para entender os efeitos dessas substâncias nos organismos aquáticos.
Over the last few decades, the occurrence of estrogenic activity and endocrine disrupting chemicals (EDCs) in aquatic environment has become a worldwide issue of increasing environmental concern. The EDCs have the ability to alter the endocrine system of organisms, and includes pharmaceuticals, personal care products, steroid hormones, industrial chemicals, pesticides and many other compounds. Such compounds are present in several industrial and domestic activities and reach the aquatic environment via wastewater discharges or agricultural runoff. The aim of this study was to determine the overall estrogenic activity of surface water, evaluate biological effects on fish embryos development, in order to propose concentrations range based on trigger value to categorize estrogenic activity. Environmental samples were also analyzed by liquid chromatography tandem mass spectrometry to identify substances that are suspected to be an endocrine disruptor. The analyzed compounds were: pesticides, hormones, triclosan, bisphenol A, octylphenol, nonylphenol, and caffeine as an indicative of anthropic activity. The estrogenic activity was measured by Bioluminescent Yeast Estrogen assay (BLYES), with the results expressed in 17β-estradiol equivalent quotient (EEQ). However, this assay is not able to provide information about adverse effects to aquatic organisms. In order to observe effects on aquatic organisms, organic extracts of surface water with results ≥ 0.1 EEQ in BLYES were tested in a bioassay using Danio rerio embryos. The methodology was conducted according OECD No. 236 and verified effects such as: lack of heart beat, lack of somites formation, non-detachment tail and coagulated embryo. Embryonic malformations were also evaluated, such as: reduction of organism size, edema and spine curvature, which are chronic effects. These effects probably are associated with contaminants mixtures. The obtained information by embryonic assay with Danio rerio was suitable to show the effects of contaminants mixture and was used to a categorization proposal of estrogenic activity. Estrogenic activity was below the limit of quantification (0.1 EEQ) in 44.8% of 116 analyzed samples, and range of estrogenic activity was from 0.11 to 14.6 EEQ. The tested samples in FET test were analyzed for acute or chronic toxicity in Danio rerio embryos. Based on the obtained results, even when estrogenic activity is present in surface water, the contaminants mixture can cause toxic effects in non-target organisms. Besides this, the widespread presence of these chemicals highlight the need for further studies in order to understand the harmfulness of these contaminants to aquatic organisms.

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41

Samuelsson, Ida. "Fortsätt blås! : En studie av kulturskolornas och musikkårernas arbete för elevernas fortsatta musicerande." Thesis, Växjö University, School of Education, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-2633.

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I denna uppsats kommer jag att undersöka hur kulturskolor och musikkårer

arbetar för att ungdomar ska vilja aktivera sig i orkesterlivet efter kulturskolan.

Uppsatsen utgår från dessa huvudteman:

 Hur ser kulturskolorna och musikkårerna på rekryteringsmöjligheterna av

ungdomar idag?

 Hur arbetar kulturskolorna och musikkårerna för att ungdomarna ska

fortsätta spela när kulturskolan är över?

 Avslutningsvis sätter jag in frågorna i ett större sammanhang och för ett

resonemang kring kulturskolornas och musikkårernas olika arbetssätt.

Undersökningen har gjorts som en enkätstudie. En enkät skickades ut

till alla Skånes 33 kommuner och en annan till 20 musikkårer. Den

största delen av musikkårerna är missnöjda med samarbetet med

kulturskolan, och med antalet ungdomar i orkestern. Svaren tyder på

att både musikkårerna och kulturskolorna är intresserade av ett

samarbete.

Slutsatserna som dras är:

 För att musikkårerna inte ska ”växa ur tiden” är det troligen nödvändigt att

ett gemensamt arbete med kulturskolan utvecklas. Detta skulle onekligen

gynna både kulturskolorna och musikkårerna!

 Det måste ske en förändring så att eleverna inte ser musicerandet och

skolan så tätt sammanbundna att de måste sluta med båda samtidigt.

3

 Kulturskolorna borde vara mer öppna för att själva ta kontakt med de

orkestrar och musikkårer som de vill samarbeta med och föreslå

samverkansprojekt.

 Musikkårerna måste vara öppna för nya arbetssätt. Att marknadsföra sig på

de rätta ställena kommer att bli avgörande för musikkårernas fortlevnad t

ex genom att utveckla en välfungerande hemsida. Troligtvis blir de även

tvungna att integrera modernare musik i sin repertoar för att locka de

yngre

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Canales, Mormontoy Pamela Elizabeth. "Caracterización molecular de bacterias amilolíticas aisladas de las salinas de San Blas - Junín." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2013. https://hdl.handle.net/20.500.12672/6925.

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Caracteriza las bacterias halófilas con actividad amilolítica provenientes de las Salinas de San Blas ubicadas en el departamento de Junín. Este estudio se realizó con 34 bacterias aisladas de muestras de suelos de las Salinas de San Blas el 2008. Primero, las bacterias se reactivaron en medio agua de sales al 5 %, de las cuales 14 hidrolizaron almidón. Los aislados amilolíticos fueron caracterizados mediante pruebas fisiológicas y bioquímicas convencionales. Tres aislados fueron Gram-negativos y once Gram-positivos. El 21, 4 % (3/14) creció en un amplio rango de concentración de sales, entre 5 y 20 %. Se encontró que 8 de 14 aislados fueron halotolerantes. De las pruebas bioquímicas se tiene que el 14, 3 % (2/14) de los aislados presentó actividad lipolítica, proteolítica y DNasa, y el 42, 9 % (6/14), presentó actividad proteolítica y DNasa. Para la caracterización molecular, se extrajo el ADN genómico de los aislados, se amplificaron y cortaron los genes ribosómicos 16S con las enzimas de restricción Hae III, BstU I, Hinf I y Cfo I. Luego, se secuenciaron parcialmente los genes ribosómicos 16S de siete aislados que presentaron perfiles de ADN diferentes y se analizaron mediante programas bioinformáticos BLASTn, CLUSTALX y MEGA. Del análisis fenotípico y molecular se obtuvieron dos grupos, uno perteneciente al género Halomonas y el otro, a Bacillus.
Tesis

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43

Trefi, Hala. "Le statut sémiotique du personnage principal dans l'Histoire de Gil Blas de Santillane." Toulouse 2, 2005. http://www.theses.fr/2005TOU20065.

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Cette thèse présente une étude du statut sémiotique du personnage principal dans l'Histoire de Gil Blas de Santillane de Lesage. Le récit dévoile une image, non pas donnée d'emblée une fois pour toutes, mais en train de se constituer. L'histoire de Gil Blas sera celle de ses changements, sa destinée celle d'un homme qui ne reste jamais sur place. Il est l'opérateur essentiel de la construction du sens dans le roman. Cette étude consiste dans le fait qu'elle témoigne d'une ouverture possible dans l'analyse des effets littéraires à partir d'une perspective sémiotique. Parler de la création du personnage de Gil Blas, désigne un ensemble de procédés par lesquels le romancier donne vie à une créature fictive et permet à l'imagination du lecteur de se représenter l'existence d'un personnage qui sera étudié comme construction langagière, comme signe, entité sémiotique. Le roman peut être lu, comme une sorte de recherche d'une construction et d'une définition du personnage principal. Gil Blas s'annonce comme une réalité objective que sur-détermine un paradigme cohérent de traits distinctifs : son nom et son territoire. Cependant, pour construire l'identité sémiotique de Gil Blas, il nous paraît nécessaire d'aborder la question des modalités avant d'entamer la recherche sur la place de Gil Blas en tant que personnage principal et héros
This thesis presents a study of the semiotic statute of the principal character in the " Histoire de Gil Blas de Santillane " of Alain-René Lesage. The account reveals an image, not given start once, but constituting progressively. The story of Gil Blas will be that of his changes, his destiny that of a man who never remains in the same place. The importance of Gil Blas is proportional to his place in the novel. He is the essential operator of the construction of the sens. This study consists in the fact that it presents a possible opening in the analysis of the literary effects starting from the semiotic prospect. Speaking about the character creation of Gil Blas, indicates a whole of processes by which the novelist gives life to a fictitious creature. That allows the reader imagination to re-incarnate the existence of a character who will be studied like linguistic construction, i. E. Like semiotic entity. The novel can be read like a kind of search of a construction and a definition of the principal character. This character is consisted the conjunction of multiple signs, which are articulated at various levels of sens. Gil Blas is announced as an objective reality that a coherent paradigm of distinctive features determines : his name and his territory. However, to build the semiotic identity of Gil Blas, it appears necessary to tackle the question of methods before starting search about the place of Gil Blas as a principal character

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Silanes, Christine. "Gil Blas de Santillane en Espagne (les signes de l'adhésion espagnole à l'espagnolade)." Paris 4, 1998. http://www.theses.fr/1998PA040077.

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Gil Blas en Espagne est le résultat de deux rencontres simultanées : l'une avec le génie littéraire du père Francisco de Isla; l'autre avec l'histoire et la société espagnoles. Etude sur un regard et une manipulation littéraire et idéologique sur le roman de Lesage, la recherche est articulée autour de trois axes. Le premier, factuel et statistique, évalue le succès de l'œuvre dans sa traduction (ou adaptation) espagnole, à partir d'une compilation bibliographique exhaustive, d'une radiographie de son lectorat et d'une recherche d'une éventuelle postérité. Le second analyse les mécanismes du processus d'appropriation à la base de l'identification et de l'adhésion hispaniques et donc clé de voute de l'insertion de Gil Blas dans l'histoire littéraire et la mémoire culturelle collective. L'étude considère le texte espagnol publié (étude comparative entre la traduction -recréation plutôt- d'Isla, ses corrections successives et le récit originel) et sa périphérie à savoir une nouvelle approche de la question Gil Blas. Le troisième envisage ce processus d'un point de vue externe, dans sa collusion avec la société, l'histoire et la littérature espagnoles - Gil Blas s'y inscrit comme un prétexte dans une querelle d'honneur de l’Espagne en réponse à la condescendance de l’Europe éclairée. Et la version d’Isla devient le maillon manquant littéraire qui permettra à l’Espagne de renouer avec sa tradition romanesque
In Spain, Gil Blas results from two simultaneous encounters: the first with the literary genius of father Francisco of Isla; the second with Spanish history and literature. Our research is a study of a perspective on and a literary and ideological manipulation of Lesage's novel, and it is organized along three lines. The first is factual and statistical. It assesses the success of the novel in its translation (or adaptation), based on a comprehensive bibliographical compilation, an analysis of its readers, and the search for a possible progeny. The second one analyses the working of the appropriation process which lies at the root of Hispanic identification and adhesion and thus forms the keystone of the insertion of Gil Blas into literary history and collective cultural memory. The study considers the published Spanish text (comparative study between Isla's translation -or rather re-creation-, its eventual corrections and the original story) and its surroundings, i. E. A new approach of the Gil Blas question. The third one considers this process from an external point of view, in its relationship with Spanish society, history and literature. Gil Blas finds its place in this tradition as a pretext in a quarrel for the honor of Spain in response to the patronizing attitude of enlightened Europe. And Isla's version becomes the literary missing link which will allow Spain to continue its novel-writing tradition

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45

Bly, Kristy Lee Sydney. "Influence of local and landscape characteristics of Prairie Dog colonies on Burrowing Owl nest ecology in South Dakota." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/bly/BlyK0508.pdf.

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In the Great Plains, sylvatic plague (Yersinia pestis), poisoning, and habitat conversion continue to reduce and fragment black-tailed prairie dog (Cynomys ludovicianus) habitat in which burrowing owls (Athene cunicularia) seek shelter and nest sites. Consequently, burrowing owls are experiencing population declines at the periphery of their range. The objective of this research was to evaluate habitat factors affecting a population of burrowing owls at the eastern extent of their range. I modeled hypothesized relationships between nest density (Chapter 2) and colony productivity (Chapter 3) and prairie dog habitat characteristics at two scales on the Bad River Ranches, South Dakota. Colony size, prairie dog and total burrow density, mean nearest neighbor and mean nest-to-colony edge distances, cover of warm-season grasses, and soil texture were variables measured at the colony level. Landscape level variables included the degree of colony isolation and the topographic location of colonies. In Chapter 4, I evaluated the spatial distribution of nests within colonies. Twenty-six prairie dog colonies were surveyed for burrowing owl nests during the 2005 (n =10) and 2006 (n = 16) breeding seasons. I evaluated competing models of nest density using a likelihood cross-validation approach. The model selection results in Chapter 2 suggested the top a priori predictor of nest density was colony size. Nest density was greatest on small colonies (<20 ha) and lowest on large colonies (>40 ha); in contrast, owl numbers were higher on large colonies. Exploratory analysis identified the interaction between cover of bare ground and colony habitat as the best approximating model of nest density. In Chapter 3, competing models of colony productivity were assessed. Although an additive model containing the degree of isolation, habitat, and colony size had a positive effect on colony productivity, exploratory analysis suggested colony size and the degree of isolation had the strongest influence. In Chapter 4, results showed that owls displayed a strong preference for nesting near colony perimeters, but this did not translate to higher productivity. The associations I observed lend support for the value of maintaining prairie dog colonies to ensure the persistence of burrowing owl populations in the Great Plains ecosystem.

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Silva, Paulo Rogério Martins da. "Remoção de atividade estrogênica do hormônio 17β-Estradiol em processos de oxidação de águas para abastecimento." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-11052016-103944/.

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Muitos oxidantes químicos reativos acarretam na ruptura de estruturas moleculares complexas de vários tipos de compostos orgânicos decompondo-as em estruturas mais simples e propiciando condições melhores para uma efetiva ação de micro-organismos na degradação biológica. A presença de hormônios, entre eles o 17β-estradiol, em estações de tratamento de esgoto e em águas subterrâneas e superficiais mostra a necessidade de uma avaliação dos processos de tratamento convencionais. O objetivo deste trabalho foi a análise e remoção de hormônios através de técnicas de cloração e ozonização de amostras reais de águas de saída de filtro de estações de tratamento de água (ETAs), operadas pelo Serviço Autônomo de Água e Esgoto (SAAE) de São Carlos (ETA Centro), que capta águas dos ribeirão Feijão e córrego Espraiado e pela Sociedade de Abastecimento de Água e Saneamento S/A (SANASA) de Campinas (ETAs 3 e 4), que capta águas do rio Atibaia. Foram realizados ensaios contaminando-se as amostras com 17β-estradiol, que é o hormônio natural mais presente no meio ambiente, em concentração de 6.000 ng L-1, submetendo-se tratamento com dosagens em torno de 0,5 e 2,0 mg L-1 desses oxidantes, em tempos de contato de, respectivamente, 10 e 30 min. As amostras submetidas à contaminação e tratamento e as de controle (sem contaminação e tratamento) foram analisadas através da remoção do 17β-estradiol com a verificação da atividade estrogênica das amostras por ensaios de Sistema de Expressão de Estrogênio Induzida por Levedura Bioluminescente (BLYES), que apresentou-se como uma ferramenta simples. Os resultados apresentados neste trabalho demonstram que a oxidação por ozônio se mostrou mais eficiente do que aquela por cloro para a remoção da atividade estrogênica causada, única e exclusivamente, pelo 17β-estradiol para uma dosagem inicial desse hormônio relativamente alta (6.000 ng L-1). Todavia, em todos os ensaios a concentração final da atividade estrogênica permaneceu acima do limite de quantificação desses hormônio, indicando que a remoção não foi completa, mesmo em condições favoráveis, isto é, matriz limpa, com padrões de potabilidade para os parâmetros físico-químicos.
Many reactive chemical oxidants cause the disruption of the complex molecular structures of various types of organic compounds decomposing them into simpler structures and providing better conditions for effective action of micro-organisms in the biological degradation. The presence of hormones, including 17β-estradiol in sewage treatment plants and groundwater and surface water shows the need for an evaluation of conventional treatment processes. The aim of this study was the analysis and removal of hormones through techniques of chlorination and ozonation of real samples of output filter water in water treatment plants (WTP), operated by the Serviço Autônomo de Água e Esgoto (SAAE) of São Carlos (Center WTP), which captures waters from Espraiado stream and Feijão stream and the Sociedade de Abastecimento de Água e Saneamento S/A (SANASA) de Campinas (WTPs 3 and 4), which captures water from the Atibaia river. Assays were performed contaminating the samples with 17β-estradiol, which is the natural hormone more present in the environment, in a concentration of 6.000 ng L-1 submitting themselves to treatment with dosages of around 0.5 to 2.0 mg L-1 of these oxidants in times of contact, respectively, 10 and 30 min. The samples subjected to contamination and treatment and control samples (without contamination and treatment) were analyzed by removing 17β-estradiol with estrogenic activity verification of the samples by Bioluminescent Assays or Estrogen-Inducible Yeast Expression System (BLYES), which was presented as a simple tool. The results presented here demonstrate that the oxidation by ozone was more effective than with chlorine to remove estrogenic activity caused solely by 17β-estradiol for an initial dosage of the hormone relatively high (6000 ngL -1) However, in all experiments the final concentration of estrogenic activity remained above the limit of quantification of these hormones, indicating that removal was not complete, even under favorable conditions, clean matrix with quality for drinking water physico-chemical parameters.

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Deregnaucourt, Sébastien. "Hybridation entre la caille des blés (Coturnix c. Coturnix) et la caille japonaise (Coturnix c. Japonica) : mise en évidence des risques de pollution génétique des populations naturelles par les cailles domestiques." Rennes 1, 2000. http://www.theses.fr/2000REN10090.

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Heitz, Benjamin Arthur. "Characterization of Novel Poly(lipid) BLMs for Long-Term Ion Channel Scaffolds Towards the Development of High-Throughput Screening Devices." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/196024.

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Suspended lipid bilayers, or black lipid membranes (BLMs), have been used to study the electrophysiological properties of ion channels (ICs); however, BLMs assembled from natural, non-polymerizable lipids are inherently unstable due to the non-covalent associations on which they are based. Lifetimes of several hours are commonly observed in BLMs until rupture due to mechanical, thermal, or chemical insults. One potential improvement is the use of polymerizable phospholipids (poly(lipids)). BLMs prepared using dienoyl functionalized poly(lipids) and binary mixtures of fluid, non-polymerizable lipids with poly(lipids) were investigated for IC recordings.poly(BLMs) exhibited enhanced lifetimes from several hours to upwards of 4 weeks while maintaining IC functionality for one week. Activity of ICs that require membrane fluidity was retained using binary phospholipid mixtures of fluid and polymeric phospholipids. IC activity was retained by inducing domain formation, wherein ICs incorporated into the fluid domains. The binary membranes exhibited marked enhancement in stability resulting from fractional poly(lipids) polymerization. Additionally, ICs can be reconstituted into the fluid domains following photopolymerization and subsequent domain formation, a key requirement when UV-sensitive ICs are utilized. Here, the electrical properties, stability, and incorporation of pore-forming ICs, including hemolysin, alamethicin, and gramicidin, into poly(lipid) membranes are reported. Potential applications developing ligand-gated IC based sensors for high throughput screening are being investigated.In parallel to the characterization of poly(lipids) for potential long-term IC membranes, a model ligand-gated IC was expressed, characterized, and reconstituted into non-polymerizable lipids. Mutant K_ATP channels were expressed in mammalian and yeast systems. The orientations of mutant K_ATP channels were studied using electrophysiological and immunohistochemical techniques. Large quantities were expressed and purified from Pichia pastoris and functionally reconstituted into BLMs. ATP and long-chaing coenzyme A ester sensitivity was maintained in reconstituted in BLMs. K_ATP channels will serve as a model system for testing the effect of poly(lipid) BLMs on IC function. Future utilization of poly(lipid) BLMs in combination with ligand-gated ICs offer major advancements to potential increased throughput for IC screening.

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Hitonen, Alexandra. "Blyg och delaktig? : Pedagogers erfarenheter av att arbeta för att främja blyga barns delaktighet." Thesis, Karlstads universitet, Estetisk-filosofiska fakulteten, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-8748.

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The purpose of this study was to examine pedagogues’ experience working with shy children and their opportunities for participation in preschool. An increasing number of children are registered in preschools today; this leading to larger groups of children and the chance for the individual child to practice its rights of having its voice heard are therefore becoming more difficult. The literature review will start with what the UNCRC and the pre-school curriculum, Lpfö 98, say about children’s participation and their right to have their voices heard. After that, shortly about the shy child, and then moving on to what is important in the work with children’s participation. Literature and research show that children are affected by the adults they meet in everyday life and also the adult’s view of the child and their ability to participate. To examine pedagogue’s experience of shy children’s participation, I used qualitative interviews with six pedagogues working at two different preschools. The result showed that pedagogue’s most important work in promoting shy children’s participation is making sure the children feel safe and building trust between adults and children. The children can then, later on, feel ready to participate in social interaction with other children. This is also where the children can come into contact with democratic values. Keywords: Shy children, participation in preschool, children’s participation

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Jareteg, Johannes. "Blås- och stråkinstrument - Coolt eller töntigt? : en inblick i undervisning i orkesterinstrument för tonåringar." Thesis, Kungl. Musikhögskolan, Institutionen för jazz, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-2656.

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Undersökningar visar att antalet instrumentelever på kulturskolor i Sverige har minskat markant de senaste decennierna (Hübner2002). Den största minskningen förefaller gälla blås- och stråkinstrument. Syftet med denna undersökning är att försöka hitta tänkbara orsaker till den minskade populariteten hos dessa instrument. Frågeställningen undersöktes med hjälp av kvalitativa intervjuer med före detta musikskoleelever, samt verksamma lärare på musikskolor. I resultatet nämns bland annat vikten av ensemblespel och musiken som ett socialt sammanhang, samt vikten av genrebredd i musiklärares undervisning. Diskussionen kretsar kring frågor om hur lärare kan arbeta för att öka populariteten för stråk- och blåsinstrument.

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Dissertations / Theses on the topic 'Blys'

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