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Journal articles on the topic '(BMDAC'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Balasubramaniam, Vivek, Sharon L. Ryan, Gregory J. Seedorf, et al. "Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 298, no. 3 (2010): L315—L323. http://dx.doi.org/10.1152/ajplung.00089.2009.

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Neonatal hyperoxia impairs vascular and alveolar growth in mice and decreases endothelial progenitor cells. To determine the role of bone marrow-derived cells in restoration of neonatal lung structure after injury, we studied a novel bone marrow myeloid progenitor cell population from Tie2-green fluorescent protein (GFP) transgenic mice (bone marrow-derived angiogenic cells; BMDAC). We hypothesized that treatment with BMDAC would restore normal lung structure in infant mice during recovery from neonatal hyperoxia. Neonatal mice (1-day-old) were exposed to 80% oxygen for 10 days. BMDACs (1 × 10
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2

Rey, Sergio, Weibo Luo, Larissa A. Shimoda, and Gregg L. Semenza. "Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue." Blood 117, no. 18 (2011): 4988–98. http://dx.doi.org/10.1182/blood-2010-11-321190.

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Abstract A major obstacle to using bone marrow cell-based therapies for ischemic cardiovascular disease is that transplanted cells must survive in an ischemic microenvironment characterized by low oxygen, glucose, and pH. We demonstrate that treatment of bone marrow-derived angiogenic cells (BMDACs) with dimethyloxalylglycine, an α-ketoglutarate antagonist that induces hypoxia-inducible factor 1 (HIF-1) activity, results in metabolic reprogramming of these cells, with increased glucose uptake, decreased O2 consumption, increased lactate production, decreased reactive oxygen species, and increa
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3

Bailey, Courtney A., Elizabeth Woodruff, Joanne Maltzahn, et al. "Abstract B069: Bone marrow-derived adipocytes promote ovarian cancer progression and metastasis." Cancer Research 84, no. 5_Supplement_2 (2024): B069. http://dx.doi.org/10.1158/1538-7445.ovarian23-b069.

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Abstract The purpose of this study is to examine the influence of bone marrow-derived adipocytes (BMDAs) on the proliferation and metastasis of high-grade serous carcinoma (HGSC), the most common and aggressive type of ovarian and fallopian tube cancer. BMDAs begin as myeloid cells that traffic to adipose tissue and differentiate into adipocytes. While histologically identical to conventional mesenchymal adipocytes (CMAs), BMDAs are a highly inflammatory subtype. BMDAs accumulate within visceral adipose depots and their production increases with age. BMDA production increases in mouse “pseudom
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4

Du, Junkai, Lixin Liu, Frank Lay та ін. "HIF-1α gene therapy combined with HIF-1 activated bone marrow-derived angiogenic cell (BMDAC) therapy improves burn wound healing in aged mice". Journal of the American College of Surgeons 215, № 3 (2012): S56. http://dx.doi.org/10.1016/j.jamcollsurg.2012.06.161.

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5

Stollings, Lindsay, Binfeng Lu, and Yan Xu. "Immunomodulation of volatile anesthetics (IRM9P.726)." Journal of Immunology 192, no. 1_Supplement (2014): 128.9. http://dx.doi.org/10.4049/jimmunol.192.supp.128.9.

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Abstract Introduction: The impact of anesthetic exposure on the immune system is relatively unknown at both mechanistic and clinical levels. In this in vitro study, we employ immunological assays and understanding of immune cell function to evaluate the effect of volatile anesthetic (VA) exposure on bone marrow dendritic cells (BMDCs). BMDCc play a critical role in antigen presentation and link the innate and adaptive arms of the immune response. Hypothesis: We believe that VA exposure may modulate immune responses, specifically BMDC function. Methods: Bone marrow cells were harvested from C57
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6

Hilfiger, John Jay. "BMDPC (Version 2.05)." American Statistician 39, no. 3 (1985): 213. http://dx.doi.org/10.2307/2683940.

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7

Mendoza, Luis, J. Bubeník, M. Indrová, J. Bieblová, V. Vonka, and J. Šímová. "Freezing and Thawing of Murine Bone Marrow-Derived Dendritic Cells Does Not Alter Their Immunophenotype and Antigen Presentation Characteristics." Folia Biologica 48, no. 6 (2002): 242–45. https://doi.org/10.14712/fb2002048060242.

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The aim of this paper was to assess whether the BMDC after freezing and thawing are capable to retain the immunophenotype and antigen-presenting capacity. BMDC were generated from bone marrow precursor cells as described previously by culturing the cells in medium containing GM-CSF and IL-4. Afterwards, the cells were harvested, counted and used for phenotyping and priming of syngeneic spleen cells. For cryopreservation, the BMDC were frozen in the presence of 10% of dimethylsulphoxide (DMSO) and 90% foetal calf serum. Forty to fifty percent of both samples, frozen/thawed as well as fresh BMDC
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8

Ohnishi, Hiroyuki, Shinya Mizuno, and Toshikazu Nakamura. "Inhibition of tubular cell proliferation by neutralizing endogenous HGF leads to renal hypoxia and bone marrow-derived cell engraftment in acute renal failure." American Journal of Physiology-Renal Physiology 294, no. 2 (2008): F326—F335. http://dx.doi.org/10.1152/ajprenal.00480.2007.

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During the progression of acute renal failure (ARF), the renal tubular S3 segment is sensitive to ischemic stresses. For reversing tubular damage, resident tubular cells proliferate, and bone marrow-derived cells (BMDC) can be engrafted into injured tubules. However, how resident epithelium or BMDC are involved in tubular repair remains unknown. Using a mouse model of ARF, we examined whether hepatocyte growth factor (HGF) regulates a balance of resident cell proliferation and BMDC recruitment. Within 48 h post-renal ischemia, tubular destruction became evident, followed by two-waved regenerat
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9

Feng, Weiyi, Maria Madajka, Bethany A. Kerr, Ganapati H. Mahabeleshwar, Sidney W. Whiteheart, and Tatiana V. Byzova. "A novel role for platelet secretion in angiogenesis: mediating bone marrow–derived cell mobilization and homing." Blood 117, no. 14 (2011): 3893–902. http://dx.doi.org/10.1182/blood-2010-08-304808.

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Abstract Angiogenesis alleviates hypoxic stress in ischemic tissues or during tumor progression. In addition to endothelial cell proliferation and migration, the angiogenic process requires bone marrow–derived cell (BMDC) recruitment to sites of neovascularization. However, the mechanism of communication between hypoxic tissues and the BM remains unknown. Using 2 models of hypoxia-induced angiogenesis (ischemic hindlimb surgery and subcutaneous tumor growth), we show that platelet infusion promotes BMDC mobilization into the circulation, BMDC recruitment into growing neovasculature, tumor vasc
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10

THORNTON, JUDITH, STEPHEN R. PYE, TERENCE W. O’NEILL, et al. "Bone Health in Adult Men and Women with a History of Juvenile Idiopathic Arthritis." Journal of Rheumatology 38, no. 8 (2011): 1689–93. http://dx.doi.org/10.3899/jrheum.101232.

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Objective.Our aim was to determine areal bone mineral density (BMDa) and disease-related factors linked with BMDa in adults with a history of juvenile idiopathic arthritis (JIA).Methods.Men and women with a history of JIA attending a young adult rheumatology clinic in Newcastle, UK, underwent dual energy x-ray absorptiometry (DEXA) of the lumbar spine and total hip. Information was obtained about disease duration and subtype, previous treatment including corticosteroid and methotrexate therapy, and large-joint replacement. Subjects completed the modified Health Assessment Questionnaire (HAQ).
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11

Labeur, Marta S., Berthold Roters, Birgit Pers, et al. "Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage." Journal of Immunology 162, no. 1 (1999): 168–75. http://dx.doi.org/10.4049/jimmunol.162.1.168.

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Abstract Bone marrow-derived dendritic cells (BmDC) are potent APC and can promote antitumor immunity in mice when pulsed with tumor Ag. This study aimed to define the culture conditions and maturation stages of BmDC that enable them to optimally function as APC in vivo. BmDC cultured under various conditions (granulocyte-macrophage CSF (GM-CSF) or GM-CSF plus IL-4 alone or in combination with Flt3 ligand, TNF-α, LPS, or CD40 ligand (CD40L)) were analyzed morphologically, phenotypically, and functionally and were tested for their ability to promote prophylactic and/or therapeutic antitumor imm
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12

Antonopoulos, Christina, William Kaiser, Edward Mocarski, Caroline El Sanadi та George Dubyak. "Pro-apoptotic chemotherapeutic drugs induce non-canonical processing and release of IL-1β via caspase-8 activation in dendritic cells (P1353)". Journal of Immunology 190, № 1_Supplement (2013): 63.29. http://dx.doi.org/10.4049/jimmunol.190.supp.63.29.

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Abstract The emergence of non-canonical (caspase-1 independent) IL-1β production has unveiled an intricate interplay between inflammatory and death-inducing signaling platforms. We compared the relative contributions of canonical versus non-canonical IL-1β processing in murine bone marrow-derived dendritic cells (BMDC) stimulated with pro-apoptotic chemotherapeutic agents such as doxorubicin (Dox). Dox induced a release of mature (17 kDa) IL-1β from LPS-primed BMDC that was temporally correlated with caspase-8 activation and greatly suppressed in BMDC from Casp8-/-Rip3-/- mice. The magnitude o
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13

Rybner-Barnier, Catherine, Catherine Jacquemot, Céline Cuche, et al. "Processing of the Bovine Spongiform Encephalopathy-Specific Prion Protein by Dendritic Cells." Journal of Virology 80, no. 10 (2006): 4656–63. http://dx.doi.org/10.1128/jvi.80.10.4656-4663.2006.

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ABSTRACT Dendritic cells (DC) are suspected to be involved in transmissible spongiform encephalopathies, including bovine spongiform encephalopathy (BSE). We detected the disease-specific, protease-resistant prion protein (PrPbse) in splenic DC purified by magnetic cell sorting 45 days after intraperitoneal inoculation of BSE prions in immunocompetent mice. We showed that bone marrow-derived DC (BMDC) from wild-type or PrP-null mice acquired both PrPbse and prion infectivity within 2 h of in vitro culture with a BSE inoculum. BMDC cleared PrPbse within 2 to 3 days of culture, while BMDC infect
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14

Segal, Mark S., Laura Sautina, Shiyu Li, et al. "Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice." Blood 119, no. 2 (2012): 629–36. http://dx.doi.org/10.1182/blood-2011-04-346007.

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The ovarian peptide hormone, relaxin, circulates during pregnancy, contributing to profound maternal vasodilation through endothelial and nitric oxide (NO)–dependent mechanisms. Circulating numbers of bone marrow–derived endothelial cells (BMDECs), which facilitate angiogenesis and contribute to repair of vascular endothelium, increase during pregnancy. Thus, we hypothesized that relaxin enhances BMDEC NO production, circulating numbers, and function. Recombinant human relaxin-2 (rhRLX) stimulated PI3K/Akt B-dependent NO production in human BMDECs within minutes, and activated BMDEC migration
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15

Ran, Hong, Jichao Yuan, Jialu Huang, Jie Wang, Kangning Chen, and Zhenhua Zhou. "Adenosine A2A Receptors in Bone Marrow-Derived Cells Attenuate Cognitive Impairment in Mice After Chronic Hypoperfusion White Matter Injury." Translational Stroke Research 11, no. 5 (2020): 1028–40. http://dx.doi.org/10.1007/s12975-019-00778-9.

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Abstract The mechanism of cognitive dysfunction caused by ischemic white matter lesions is unclear. To explore the effect and mechanism of different cell-derived adenosine A2A receptor (A2AR) in cognitive impairment caused by chronic hypoperfusion white matter lesions (CHWMLs), we destroyed the bone marrow hematopoietic capacity of the recipient mice using radiation irradiation followed by establishing the selectively inactivated or reconstituted A2AR models with the transplanting bone marrow from global A2AR gene knockout or wild-type mice into wild-type or gene knockout mice, respectively. T
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16

Liebler, Janice M., Carolyn Lutzko, Agnes Banfalvi, et al. "Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 295, no. 2 (2008): L285—L292. http://dx.doi.org/10.1152/ajplung.00222.2007.

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We studied the capacity of adult human bone marrow-derived cells (BMDC) to incorporate into distal lung of immunodeficient mice following lung injury. Immunodeficient NOD/SCID and NOD/SCID/β2microglobulin (β2M)nullmice were administered bleomycin (bleo) or saline intranasally. One, 2, 3 and 4 days after bleo or saline, human BMDC labeled with CellTracker Green CMFDA (5-chloromethylfluorescein diacetate) were infused intravenously. Retention of CMFDA+cells was maximal when delivered 4 days after bleo treatment. Seven days after bleo, <0.005% of enzymatically dispersed lung cells from NOD/SCI
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17

Sumpter, Tina, Brian Janelsins, Darling Rojas-Canales, et al. "Neurokinin-1 receptor stimulated dendritic cell vaccines downregulate IL-10 and license host inflammatory dendritic cells to bias Th1 immunity (P4236)." Journal of Immunology 190, no. 1_Supplement (2013): 47.6. http://dx.doi.org/10.4049/jimmunol.190.supp.47.6.

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Abstract Substance-P (SP) is a neuropeptide that stimulates immunity by binding to the neurokinin-1 receptor (NK1R). As professional Ag presenting cells, dendritic cells (DC) are unique activators of naïve T cells. DC express functional NK1R, indicating that NK1R agonists may influence their T cell-stimulatory function. Relevant studies analyzing the relationship between neuropeptides and DC function are lacking. Here, we demonstrate that conditioning bone marrow derived DC (BMDC) with NK1R agonists leads to maturation and abrogation of IL-10 without inducing secretion of IL-12p70. Mechanisti
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18

Olguín Alor, Roxana, Xochitl Ambriz Peña, Germán Rodrigo Aleman-Muench, et al. "Role of inhibins in dendritic cells differentiation and maturation (P4482)." Journal of Immunology 190, no. 1_Supplement (2013): 52.58. http://dx.doi.org/10.4049/jimmunol.190.supp.52.58.

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Abstract Dendritic cells (DC) play a central role establishing the balance between tolerance and immunity. Inhibins and Activins, members of the TGFβ superfamily, have been implicated in the immune system as keys regulators of cellular functions, such as proliferation, apoptosis and differentiation. Several reports have previously shown the role of Activins in DC maturation and function, however the role of their closely related cytokines, the Inhibins, in those processes remains unclear. In this study, we compare the differentiation and maturation of bone marrow derived DC (BMDC) of wild type
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19

Seishima, Noriko, Purevdorj B. Olkhanud, William Becker, et al. "Peptide-pulsed MHC class II mutant dendritic cell vaccine has superior efficacy in a murine tumor model." Journal of Immunology 210, no. 1_Supplement (2023): 159.10. http://dx.doi.org/10.4049/jimmunol.210.supp.159.10.

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Abstract Autologous dendritic cell (DC) vaccines with tumor antigens have been used clinically with limited therapeutic effects. Semi-allogeneic DC-based immunotherapy is still controversial, but it can be an alternative source and more attractive than autologous DC vaccines because the “off-the-shelf” DCs can be used for multiple patients without lengthy individual manufacturing time and may provide additional “allogeneic help”. This study aims to compare efficacy of syngeneic DC vaccines and semi-allogeneic DC vaccines and determine whether a therapeutic semi-allogeneic DC vaccine is more ef
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20

Indrová, Marie, M. Reiniš, J. Bubeník, et al. "Immunogenicity of Dendritic Cell-Based HPV16 E6/E7 Peptide Vaccines: CTL Activation and Protective Effects." Folia Biologica 50, no. 6 (2004): 184–93. https://doi.org/10.14712/fb2004050060184.

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We have investigated the capacity of cellular vaccines based on dendritic cells loaded with human HPV16 E6/E7 oncoprotein-derived peptides to induce immune responses in vitro and to elicit protective immunity in a murine experimental model mimicking human HPV16-associated carcinomas. Dendritic cells loaded with the HPV16 E6/E7 peptides exhibiting CTL or Th epitopes (E641-50, E681-90, E698-107, E6130-137, E749-57, and E744-62) were able to stimulate in vitro DNA synthesis in syngeneic H-2b spleen cells. The priming capacity of peptide-loaded BMDC and peptide-loaded dendritic cell lines DC2.4 an
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Rhoads, Jillian, Ashley Wilhelm, Jared Moore, and Amy Major. "Oxidized low density lipoprotein immune complexes act as a priming signal for the NLRP3 inflammasome (HUM1P.253)." Journal of Immunology 194, no. 1_Supplement (2015): 52.2. http://dx.doi.org/10.4049/jimmunol.194.supp.52.2.

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Abstract Antibodies to oxidized LDL (oxLDL) and resulting immune complexes (ICs) are a prominent feature of atherosclerosis and autoimmune diseases associated with increased atherosclerosis. Although levels of oxLDL-ICs correlate with disease severity, it is unclear whether these ICs play an active role in disease pathogenesis. We hypothesize that oxLDL-ICs exacerbate atherosclerosis by signaling through multiple receptors on dendritic cells (DCs) resulting in an inflammatory adaptive immune response. To test this hypothesis, bone marrow derived dendritic cells (BMDC) were incubated with oxLDL
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22

Nelson, Michelle, Alison Johnson, and Gregg Milligan. "Investigation of TLR ligand-generated inflammatory signals for the induction of high magnitude memory CD8+ T lymphocyte responses (52.14)." Journal of Immunology 186, no. 1_Supplement (2011): 52.14. http://dx.doi.org/10.4049/jimmunol.186.supp.52.14.

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Abstract Most currently used vaccines elicit antibody and CD4+ T cells, but protection against some pathogens also require a CD8+ T cell response. CD8+ T cells can be readily elicited using live attenuated vaccines or non-viable vaccine antigens in combination with adjuvants. However, little is known about how adjuvants affect the elicited CD8+ T cell response. We examined the ability of different adjuvant stimuli (TLR ligands CpG, MPL and Poly(I:C)) to elicit critical signals in bone marrow-derived dendritic cells (BMDC) necessary for appropriate development of antigen-specific CD8+ memory T
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23

Orr, Selinda, Laura Quigley, Stephen Roessler, et al. "LAB/NTAL regulates zymosan-mediated inflammatory responses in Bone Marrow Derived Dendritic Cells (BMDC) (98.14)." Journal of Immunology 184, no. 1_Supplement (2010): 98.14. http://dx.doi.org/10.4049/jimmunol.184.supp.98.14.

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Abstract Immune sensing of fungi occurs via multiple pathogen recognition receptors such as Dectin-1/2, mannose receptor and TLR2. The β-glucans and mannans in fungal cell walls activate these receptors. Stimulation of DCs via TLR2 results in the production of IL-10 and little IL-12, while Dectin-1 utilizes a hemi-ITAM (immunoreceptor tyrosine based activation motif) and Syk to facilitate IL-23 production leading to Th17 polarization. We have recently shown that the linker for activation of B cells/Non-T cell activating linker (LAB/NTAL), a known regulator of ITAM-mediated signaling, is expres
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24

Mitchell, Latoya M., Jason Grayson, and Elizabeth M. Hiltbold. "The Effects of Listeria monocytogenes Infection on Dendritic Cell Subsets (43.16)." Journal of Immunology 178, no. 1_Supplement (2007): S39. http://dx.doi.org/10.4049/jimmunol.178.supp.43.16.

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Abstract Dendritic cells (DC) are antigen presenting cells that link innate and adaptive immunity and have been shown to be a vital component for clearance and protection against Listeria monocytogenes (Lm) infection. Because of the role of DC in immunity against Lm and the varied functional capacities of DC subsets, our goal is to determine the impact of Lm infection on CD8α+/CD24+, myeloid, and plasmacytoid DC subsets found in Flt3L bone-marrow derived DC (BMDC) and mouse spleen. Previously, we found that Flt3L BMDC undergo maturation upon infection with wild-type Lm as well as a Hly− mutant
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25

Mendoza, Luis, J. Bubeník, J. Šímová, et al. "Tumour-Inhibitory Effects of Dendritic Cells Administered at the Site of HPV 16-Induced Neoplasms." Folia Biologica 48, no. 3 (2002): 114–19. https://doi.org/10.14712/fb2002048030114.

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Experiments were designed to examine whether administration of APC at the site of HPV 16-associated tumours can inhibit tumour growth and whether the efficacy of established dendritic cell lines is comparable to that of fresh BMDC populations. Mice were inoculated s.c. with APC, either bone marrow-derived dendritic cells differentiated in medium supplemented with GM-CSF and IL-4 (BMDC), or with established dendritic cell lines DC2.4 or JAWS II. The pretreated mice, together with untreated controls, were challenged with syngeneic HPV 16-transformed cells MK16 at the site of APC administration.
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26

Li, Li, Liping Huang, Hong Ye та ін. "Resident Dendritic Cell (DC) Activation Initiates Early Innate Response to Kidney Ischemia-Reperfusion Injury (IRI) and Inflammation via IL-23/IL-17 and IL-12/IFN-γaxis (B72)". Journal of Immunology 178, № 1_Supplement (2007): LB15. http://dx.doi.org/10.4049/jimmunol.178.supp.b72.

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Abstract DCs contribute to innate immunity, autoimmunity and host defense through IL-12/IFN-γ and/or IL-23/IL-17 pathways. Although DC is the dominant kidney leukocyte subset, its role in the early IRI is unknown. We hypothesize that early kidney IRI is characterized by resident DC activation leading to IL-12/IFN-γ and IL-23 production. Depletion of DCs using lipsoomal clodronate prior to IRI led to kidney protection, which indicated the importance of DCs. DC triggered NKT cell IFN-γ production and its effect on kidney IRI was investigated by using αGalCer-primed BMDC. Adoptive transfer of BMD
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27

Liontos, Larissa, and C. Jane McGlade. "The Src-Like Adaptor Proteins, SLAP and SLAP2, Regulate Flt3-Dependent Dendritic Cell Development." Blood 112, no. 11 (2008): 1535. http://dx.doi.org/10.1182/blood.v112.11.1535.1535.

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Abstract The Src-like Adaptor Proteins, SLAP and SLAP2, are hematopoietic adaptor proteins that have been previously shown to act as negative regulators of T- and B-cell signaling. SLAP and SLAP2 work in conjunction with the E3 ubiquitin ligase, c-Cbl, to down regulate the T-cell receptor and other components of the T- and B-cell receptor signaling pathways including ZAP-70 and Syk. SLAP and SLAP2 are expressed in many hematopoietic cell types, including progenitor cells that give rise to cells of both myeloid and lymphoid lineages. Recent evidence indicates a role for SLAP and SLAP2 in regula
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28

Siqueiros Beltrones, David A., Francisco Omar López-Fuerte, Yuriko Jocselin Martínez, and María del Carmen Altamirano-Cerecedo. "A First Estimate of Species Diversity for Benthic Diatom Assemblages from the Revillagigedo Archipelago, Mexico." Diversity 13, no. 10 (2021): 458. http://dx.doi.org/10.3390/d13100458.

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Recent investigations at previously unexplored localities on the Mexican coast have confirmed the high taxonomic potential of benthic marine diatom assemblages (BMDA) in the region. An exploratory study of epiphytic diatoms of macroalgae in the Revillagigedo Archipelago (RA) suggested that further studies would yield many more taxa, prompting the hypothesis that diversity measurements, based on ecological indices, would be among the highest in pristine environments. Thus, the aim of this research was to enrich the record of epiphytic diatom floristics of the RA, and to estimate species diversi
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29

Rozanski, Cheryl H., Jayakumar Nair, Louise Carlson, and Kelvin P. Lee. "CD28 Supports Normal Plasma Cell Survival and Interactions with Microenvironment." Blood 112, no. 11 (2008): 2713. http://dx.doi.org/10.1182/blood.v112.11.2713.2713.

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Abstract The long term generation of protective antibodies (Abs) requires the continuous survival of long-lived plasma cells that are maintained within specialized bone marrow niches by complex interactions that remain largely uncharacterized. Previous studies have shown that the T cell costimulatory receptor CD28 is expressed on normal and transformed (murine plasmacytoma, human multiple myeloma) plasma cells – however, its role in the B cell lineage remained unclear. We have recently shown that CD28 expressed on transformed human plasma cells (multiple myeloma cells) directly delivers pro-su
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30

Miller, W. L., A. Kazanova, M. Brouillard-Galipeau, C. Gavino, and S. Gruenheid. "A72 INFLUENCE OF THE MICROBIOME ON DENDRITIC CELL FUNCTION." Journal of the Canadian Association of Gastroenterology 8, Supplement_1 (2025): i28—i29. https://doi.org/10.1093/jcag/gwae059.072.

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Abstract Background The intestinal microbiome educates the immune system, in part through signaling in antigen- presenting cells including dendritic cells (DCs). Germ-free mice exhibit DC deficiency, migration impairment, and priming dysfunction, implying a relationship between microbiota and DC function. Naturally acquired, endemic Helicobacter species (H. spp.) such as H. hepaticus are common in many mouse colonies, whereas some facilities are Helicobacter-free. Aims Although they do not cause overt disease in most immune-competent mouse strains, we hypothesized that H. spp. could be a sourc
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31

Belay, Tesfaye. "Cold-induced stress impairs the production of Th1 protective cytokines during co-culturing of dendritic cells and naïve T helper cells of Chlamydia muridarum infected mice." Journal of Immunology 200, no. 1_Supplement (2018): 117.35. http://dx.doi.org/10.4049/jimmunol.200.supp.117.35.

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Abstract The purpose of this study was to determine how cold-induced stress affects the maturing of mouse bone marrow-derived dendritic cells (BMDCs) and to see the dynamics of cytokines production associated with T helper subtypes. Quantitative real time PCR and ELISA were used to measure gene expression and production of cytokines in co-culture of BMDC and Naïve CD4+ T cells. Culturing BMDC in vitro stimulated with LPS in the presence of norepinephrine (NE) or Feroterol, β-AR agonist resulted in a marked increase (75 pg/ml) of IL-10 compared to that of stressed mice. Treatment with β-AR anta
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32

Feng, Weiyi, N. Patrick McCabe, Ganapati H. Mahabeleshwar, Payaningal R. Somanath, David R. Phillips та Tatiana V. Byzova. "The angiogenic response is dictated by β3 integrin on bone marrow–derived cells". Journal of Cell Biology 183, № 6 (2008): 1145–57. http://dx.doi.org/10.1083/jcb.200802179.

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Angiogenesis is dependent on the coordinated action of numerous cell types. A key adhesion molecule expressed by these cells is the αvβ3 integrin. Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β3 integrin on bone marrow–derived cells (BMDCs) recruited to sites of neovascularization. Using knockin mice expressing functionally stunted β3 integrin, we show that bone marrow transplantation rescues impaired angiogenesis in these mice by normalizing BMDC recruitment. We demonstrate th
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Hashimoto, Kahoko, Tomoyuki Suzuki, Ryo Sakai, et al. "Innate immunity activation in mouse dendritic cells infected by Baculovirus (B188)." Journal of Immunology 178, no. 1_Supplement (2007): LB39. http://dx.doi.org/10.4049/jimmunol.178.supp.b188.

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Abstract Baculovirus is an insect virus of double stranded, which has been used as a powerful tool for producing of recombinant proteins. In most cases, as mammalian cells have not been infected by the baculovirus, the infection can induce the activation in innate immunity system. For this reason, we investigated how baculovirus induce the innate immunity in the mouse bone marrow derived dendritic cells (BMDC). Among the lymphoid cells and tissues, baculovirus could activate BMDC and also macrophage cell line; RAW264.7 much more than T cells, B cells or NK cells. By the baculovirus infection,
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34

Viriyakosol, Suganya, Maria del Pilar Jimenez, Sinobu Saijo, and Joshua Fierer. "Neither Dectin-2 nor the Mannose Receptor Is Required for Resistance to Coccidioides immitis in Mice." Infection and Immunity 82, no. 3 (2013): 1147–56. http://dx.doi.org/10.1128/iai.01355-13.

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ABSTRACTWe investigated the roles of the mannose receptor (MR) and Dectin-2 in resistance to pulmonary coccidioidomycosis in C57BL/6 (B6) mice and in the interaction of myeloid cells with spherules, using B6 mice with targeted mutations inMrc1andClec4n. Spherules are the tissue form ofCoccidioides, and we determined that the MR on bone marrow-derived dendritic cells (BMDC) was important for recognition of spherules (formalin-killed spherules [FKS]) and for secretion of interleukin 10 (IL-10) and proinflammatory cytokines in response to FKS by both elicited macrophages and BMDC. Infected MR kno
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Fonseca, Wendy, Sihyug Jang, Andrew Rasky та ін. "Lactobacilus johnsonii supplemented mice modulate RSV-induced disease and is associated with increased DHA metabolite that alters DC activation through PPAR- γ. (VIR9P.1148)". Journal of Immunology 194, № 1_Supplement (2015): 215.14. http://dx.doi.org/10.4049/jimmunol.194.supp.215.14.

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Abstract The gut microbiome contributes to a variety of mammalian processes, including modulation of host immune responses. We have found that L. johnsonii-supplemented mice displayed altered gut microbiome profiles and reduced RSV-induced pulmonary immunopathology. Metabolomics analysis of plasma from L. johnsonii-supplemented mice identified docosahexaenoic acid (DHA) and 2-hydroxyisobutyrate (butyrate precursor) as increased metabolites. We hypothesized that DHA and butyrate played a role in the modulation of the immune response in lung. We found that bone marrow-derived dendritic cells (BM
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36

Butts, Cherie L., Elena Belyavskaya, and Esther M. Sternberg. "Dendritic Cells from Male and Female Rodents Respond Differentially to Progesterone (90.3)." Journal of Immunology 178, no. 1_Supplement (2007): S157. http://dx.doi.org/10.4049/jimmunol.178.supp.90.3.

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Abstract Females show a 2- to 10-fold higher incidence of autoimmune diseases compared to males, indicating a role for sex hormones. In this study, we determined the role of progesterone (P) in modulating male and female rodent dendritic cell (DC) responses. We found differences both in male and female DC responses to P and differences in DC responses throughout the female estrus cycle. Male LPS-matured bone marrow-derived DCs (BMDCs) secreted higher levels of TNF-? and IL-10 compared to females; however P suppressed BMDC TNF-? and IL-12 secretion in females more than males. Reversal by the PR
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37

Williams, Natasha L., Jodie L. Morris, Catherine M. Rush, and Natkunam Ketheesan. "Migration of Dendritic Cells Facilitates Systemic Dissemination of Burkholderia pseudomallei." Infection and Immunity 82, no. 10 (2014): 4233–40. http://dx.doi.org/10.1128/iai.01880-14.

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ABSTRACTBurkholderia pseudomallei, the etiological agent for melioidosis, is an important cause of community-acquired sepsis in northern Australia and northeast Thailand. Due to the rapid dissemination of disease in acute melioidosis, we hypothesized that dendritic cells (DC) could act as a vehicle for dissemination ofB. pseudomallei. Therefore, this study investigated the effect ofB. pseudomalleiinfection on DC migration capacity and whether migration of DC enabled transportation ofB. pseudomalleifrom the site of infection.B. pseudomalleistimulated significantly increased migration of bone ma
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Kerr, Bethany A., and Tatiana V. Byzova. "Platelet Sequestered Proteins Mediate Pre-Metastatic Communication Between Tumors and Bone." Blood 122, no. 21 (2013): 1063. http://dx.doi.org/10.1182/blood.v122.21.1063.1063.

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Abstract Tumors can be considered parasites that exploit the host’s resources in order to promote their own growth. Tumors secrete growth factors and cytokines (tumor secretome) which recruit platelets, blood vessels, and bone marrow-derived cells (BMDCs) to promote angiogenesis and tumor progression. We have recently demonstrated that distant tumor growth can stimulate bone formation and BMDC mobilization prior to metastasis. However, the mechanism of communication between the primary tumor and the bone microenvironment remains unknown. Signals from the tumor to the bone microenvironment are
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39

Namagembe, Habiba, Christopher Samuel Mayanja, and Rashid Kinsambwe. "School Management Committee monitoring principles and performance of Government Aided Muslim-founded Primary Schools in Bugisu Muslim District Council, Uganda." East African Journal of Arts and Social Sciences 5, no. 1 (2022): 234–43. http://dx.doi.org/10.37284/eajass.5.1.729.

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Globally, monitoring and evaluation have taken centre stage in the development process. This is due to the fact that without measuring progress and performance, organisations may not know whether they are achieving. It has been observed over the years that Muslim-founded educational institutions have suffered performance issues the world over. In Uganda, it has been noted that Muslim-founded primary schools attempt to involve School Management Committees during monitoring activities. However, the report of BMDC (2018) indicates that the performance of Government Aided Muslim-founded Primary Sc
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Seishima, Noriko, William Becker, Purevdorj Olkhanud, et al. "Peptide-pulsed MHC class II allogeneic dendritic cell vaccine has superior efficacy providing allogeneic help in a murine cancer model." Journal of Immunology 212, no. 1_Supplement (2024): 1097_4946. http://dx.doi.org/10.4049/jimmunol.212.supp.1097.4946.

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Abstract Allogeneic dendritic cell (DC) cancer vaccines present a promising alternative to autologous counterparts, offering an “off-the-shelf” solution for multiple patients and providing additional allogeneic help. We assessed the efficacy of a semi-allogeneic DC vaccine in comparison to a syngeneic one for tumor suppression. C57BL/6 mice were inoculated subcutaneously with human papillomavirus E6 and E7-expressing TC-1 cells. Syngeneic bone marrow DCs (BMDCs) were generated from C57BL/6 and semi-allogeneic BMDCs with a point mutation on either MHC class I or II were generated from B6.C-H2-K
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Contractor, Nikhat, and David C. Frantz. "Modulation of Toll-like receptor-stimulated dendritic cell cytokine production by exogenous osteopontin. (98.32)." Journal of Immunology 182, no. 1_Supplement (2009): 98.32. http://dx.doi.org/10.4049/jimmunol.182.supp.98.32.

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Abstract Osteopontin (OPN) is a pleiotropic cytokine produced by mast cells, macrophages, activated T cells, NK T cells and dendritic cells and is present at high levels in human milk. Several studies in OPN-deficient mice have suggested a role for OPN in the development of Th1 and Th17 mediated immune responses. Dendritic cells (DC) are central regulators of T helper cell responses, however, it is unknown whether exogenous OPN supplied by milk plays a role in the differentiation of DC upon activation by signals through the TLRs. To address this question, we assessed the role of OPN in the LPS
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Zirnheld, Arin, Chunlan Fan, Michele Kosiewicz та Pascale Alard. "β-catenin modulates inflammatory cytokine production and disease development in NOD mice (P5231)". Journal of Immunology 190, № 1_Supplement (2013): 67.14. http://dx.doi.org/10.4049/jimmunol.190.supp.67.14.

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Abstract Because of their various immune defects including the excess production of proinflammatory cytokines by dendritic cells, non-obese diabetic (NOD) mice provide a powerful model to understand Type I diabetes. We have found increased levels of nuclear and cytosolic β-catenin in BMDC from NOD mice. We have assessed its association with inflammatory cytokine production and disease development, and the reason for its accumulation. First, we transfected NOD or B6g7 BMDC with β-catenin siRNA or β-catenin plasmid and measured IL-12 production. We found that modulating β-catenin expression infl
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Nelson, Michelle, Alison Johnson, Chin-Fun Chu, and Gregg Milligan. "Investigation of TLR ligand-generated inflammatory signals for the induction of high magnitude memory CD8+ T lymphocyte responses (42.8)." Journal of Immunology 184, no. 1_Supplement (2010): 42.8. http://dx.doi.org/10.4049/jimmunol.184.supp.42.8.

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Abstract Most currently used vaccines elicit antibody and CD4+ T lymphocytes, but protection against some pathogens may also require a CD8+ T cell response. We are examining the ability of specific TLR agonists to stimulate a specific third signal, such as IL-12 and type 1 interferons, in bone marrow-derived dendritic cells (BMDC) necessary for appropriate development of antigen-specific memory CD8+ T cells against HSV-2. TLR4 (MPL) and TLR9 (CpG) ligands elicit high IL-12 and low IFN-α/β, while TLR3 (Poly(I:C)) ligands generate the opposite cytokine response. Initial in vitro studies demonstr
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Chou, Ping-Jen, Cathy Newton, Izabella Perkins, Herman Friedman, and Thomas Klein. "Evaluation of function vs. purity of mouse bone marrow derived dendritic cells by analyzing FACS and ELISA profiles of CD11c-selected and non-selected populations (36.26)." Journal of Immunology 178, no. 1_Supplement (2007): S17. http://dx.doi.org/10.4049/jimmunol.178.supp.36.26.

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Abstract Bone marrow derived dendritic cells are APCs and serve as “immunological sensors” that detect microbial invasion. The hallmark of BMDC purity is >90% positive for the CD11c molecular marker and this level of purity can be achieved by the use of costly cell sorters. A confound to the methods of isolation and purification is that growing BMDC in GM-CSF enriched culture medium can increase the CD11c expression <75%. In this study, BMDC were harvested and enriched by incubation for 9 days with GM-CSF medium followed by CD11c IMag™ Magnetic Particle selection. The selected an
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45

Zamora-Pineda, Jesus Bernabe, and Katherine L. Knight. "Immune Tolerance Induction by the Exopolysaccharide from the Probiotic Bacillus subtilis." Journal of Immunology 204, no. 1_Supplement (2020): 152.24. http://dx.doi.org/10.4049/jimmunol.204.supp.152.24.

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Abstract Intestinal microbiota can lessen the severity of inflammatory diseases, although the mechanisms by which this occurs are poorly understood. We showed that exopolysaccharide (EPS) from the probiotic Bacillus subtilis induces anti-inflammatory macrophages and protects mice from enteric infection and sepsis. Here, we examined the molecular mechanisms by which EPS induces an anti-inflammatory response. In co-cultures of OVA-loaded bone marrow-derived dendritic cells (BMDC) and OT-II T cells, EPS inhibits T cell activation in a TLR4-dependent manner. We hypothesize that EPS engages TLR4 an
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46

Körner, Ulrich, Veronika Fuss, Jutta Steigerwald, and Heidrun Moll. "Biogenesis of Leishmania major-Harboring Vacuoles in Murine Dendritic Cells." Infection and Immunity 74, no. 2 (2006): 1305–12. http://dx.doi.org/10.1128/iai.74.2.1305-1312.2006.

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ABSTRACT In mammalian hosts, Leishmania sp. parasites are obligatory intracellular organisms that invade macrophages and dendritic cells (DC), where they reside in endocytic organelles termed parasitophorous vacuoles (PV). Most of the present knowledge of the characteristics of PV harboring Leishmania sp. is derived from studies with infected macrophages. Since DC play a key role in host resistance to leishmaniasis, there is a need to understand the properties and biogenesis of PV in Leishmania sp.-infected DC. Therefore, we determined the acquisition of endosomal and lysosomal molecules by Le
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47

Sadeghi Shermeh, Atefeh, Sima HAbibzadeh, Adeleh Taghikhani, Sima Rafati, and Negar Seyed. "Optimized Mouse BMDC Isolation and Culture under Endotoxin-Free Conditions." journal of ilam university of medical sciences 29, no. 2 (2021): 43–54. http://dx.doi.org/10.52547/sjimu.29.2.43.

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48

Hosseini, Seyed Mojtaba, Tahere Talaei-khozani, Mahsa Sani, and Bahareh Owrangi. "Differentiation of Human Breast-Milk Stem Cells to Neural Stem Cells and Neurons." Neurology Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/807896.

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Objectives.Human breast milk contains a heterogeneous population of cells that have the potential to provide a noninvasive source of cells for cell therapy in many neurodegenerative diseases without any ethical concern. The objectives of this study were to differentiate the breast milk-derived stem cells (BMDSC) toward neural stem cells and then into the neurons and neuroglia.Materials and Methods.To do this, the BMDSC were isolated from human breast milk and cultured in Dulbecco’s modified Eagle medium/F12 (DMEM/F12) containing fibroblast growth factor (bFGF). The cells were then characterize
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49

Rozanski, Cheryl H., Ramon Arens, Louise Carlson, et al. "Long Term Humoral Immunity Is Dependent on CD28 Expression In Plasma Cells." Blood 116, no. 21 (2010): 1737. http://dx.doi.org/10.1182/blood.v116.21.1737.1737.

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Abstract Abstract 1737 Protective immunity against infection requires sustained antibody production by long-lived plasma cells (LLPC) that survive for years/decades within specialized niches. What regulates/supports this survival remains largely unknown. However, is has been shown normal and transformed (human multiple myeloma) LLPC are critically dependent on the bone marrow microenvironment including cell-to-cell interactions. Leading us to rationalize, modulating this interaction could either enhance antibody production for cancer vaccine development or conversely compromise the survival of
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50

Pejawar, Sharmila S., Griffith D. Parks, and Martha A. Alexander-Miller. "Abortive versus Productive Viral Infection of Dendritic Cells with a Paramyxovirus Results in Differential Upregulation of Select Costimulatory Molecules." Journal of Virology 79, no. 12 (2005): 7544–57. http://dx.doi.org/10.1128/jvi.79.12.7544-7557.2005.

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ABSTRACT Dendritic cells are the most potent antigen-presenting cell for priming naive T cells. Optimal activation of T cells requires that dendritic cells undergo a process of maturation resulting in the increased expression of costimulatory molecules, such as CD40, CD86, and CD80, and the production of cytokines. In this study we analyzed the effect of infection of dendritic cells obtained from two strains of mice, BALB/c and C57BL/6, with the paramyxovirus simian virus 5 (SV5). Our results show that C57BL/6 bone marrow-derived dendritic cells (BMDC) are much more permissive to infection wit
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