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1
Lelièvre, Hubert. "Espaces bmo et multiplicateurs idempotents." Paris 6, 1995. http://www.theses.fr/1995PA066372.
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On etudie une generalisation des espaces bmo et des espaces de hardy classiques en remplacant les normes d'espace de lebesgue par des normes d'orlicz dans les definitions. Notre but, ensuite, c'est la generalisation de l'inegalite classique de paley dans le cas des fonctions a valeurs aussi bien scalaires que vectorielles. Cela nous permet de mettre en evidence des sous-espaces de fonctions, remarquables engendres par des suites lacunaires. Par la methode d'interpolation de peetre, on calcule des espaces intermediaires entre l'espace bmo et l'espace des fonctions essentiellement bornees. La derniere partie de la these est consacree aux multiplicateurs idempotents sur des espaces de type bmo
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Hu, Yingfeng. "John-Stromberg Inequality for Certain Anisotropic BMO Spaces." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527117965732799.
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Luong, Dang Ky. "Décomposition bilinéaire du produit H1-BMO et problèmes liés." Phd thesis, Université d'Orléans, 2012. http://tel.archives-ouvertes.fr/tel-00873786.
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Um, Ko Woon. "Elliptic equations with singular BMO coefficients in reifenberg domains." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/753.
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W1,p estimate for the solutions of elliptic equations whose coefficient matrix can have large jump along the boundary of subdomains is obtained. The principal coefficients are supposed to be in the John-Nirenberg space with small BMO seminorms. The domain and subdomains are Reifenberg flat domains and moreover, it has been shown that the estimates are uniform with respect to the distance between the subdomains.
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Gomes, Luis Antonio Pereira. "Espaços H1 e BMO não-isotropicos e operadores integrais singulares vetoriais." [s.n.], 1992. http://repositorio.unicamp.br/jspui/handle/REPOSIP/306942.
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Orientador: Dicesar Lass FernandezTese (doutorado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Ciencia da Computação
Made available in DSpace on 2018-07-17T08:57:37Z (GMT). No. of bitstreams: 1 Gomes_LuisAntonioPereira_D.pdf: 2230257 bytes, checksum: e9ce8bd3094bb3ba08d97d9e1544333d (MD5) Previous issue date: 1992
Resumo: Não informado.
Abstract: Not informed.
Doutorado
Doutor em Ciências
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Dalenc, Laurent. "Characterization of product BMO and iterated commutators involving Calderon-Zygmund operators." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2469/.
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Le but de ma thèse est de décrire les familles d'opérateurs de Calderon-Zygmund qui, imbriqués au sein de commutateurs, caractérisent BMO à plusieurs paramètres. L'espace BMO à plusieurs paramètres est une généralisation de l'espace BMO classique, et a commencé à être étudié au cours des années 1980 par Chang et Fefferman. A chaque paramètre, on associe un opérateur de Calderon-Zygmund agissant sur ce paramètre, un opérateur de Calderon-Zygmund étant un opérateur à noyau. Ensuite, si b appartient à BMO, on lui associe l'opérateur Mb de multiplication par b. On considère ensuite une suite d'itérés de commutateurs ayant pour argument ces opérateurs de Calderon-Zygmund et Mb. Le but est alors d'étudier le rapport entre la norme BMO de b et celle de ces itérés de commutateurs agissant sur L2. Le premier résultat concernant cette théorie est du à Coifman, Rochberg et Weiss qui ont démontré dans le cas du paramètre un que les transformées de Riesz, qui sont des opérateurs de Calderon-Zygmund, caractérisent BMO. Le résultat suivant est du à Uchiyama, qui, lui, a proposé un critère portant sur une famille d'opérateurs de Calderon-Zygmund, pour savoir s'ils généralisent la décomposition de Stein-Fefferman, puis Li a fourni un critère englobant celui de Uchiyama pour savoir si un commutateur caractérise BMO à un paramètre. Le premier théorème dans le cas du multiparamètre est du à Ferguson-Lacey qui ont montré dans le cas du paramètre t=2 que les transformées de Hilbert caractérisent BMO, puis Lacey-Ferguson l'ont étendu à un nombre quelconque d'itérations. Enfin, Lacey-Petermichl-Wick-Pipher ont étendu ce résultat aux transformées de Riesz dans le cas du multiparamètre. C'est, dans un premier temps, ce résultat que l'on a généralisé, fournissant un critère permettant de savoir si une famille d'opérateurs de Calderon-Zygmund caractérisent BMO à plusieurs paramètres. Enfin, nous avons montré que la norme du commutateur est, à une constante multiplicative près, majorée par la norme BMO de b pour n'importe quel type d'opérateurs de Calderon-Zygmund, en utilisant le théorème de représentation d'Hytonen qui permet de réduire le problème au cas des shifts dyadiquesThe aim of my thesis was to find criteria on families of Calderon-Zygmund operators to know if, with iterated commutators, they characterize product BMO space. Multiparameter BMO space is a generalization of classical BMO space, and began to be studied during the eighties by Chang and Fefferman. To each parameter is associated a Calderon-Zygmund operator acting on this parameter. We define also, associated to b in BMO, the operator Mb of multiplication by b. Then we define iterated commutators with those Calderon-Zygmund operators and the operator Mb. Then the aim is to study the relation between the BMO norm of b and the norm of the commutator acting on L2. The first result in one parameter case is due to Coifman, Rochberg and Weiss, who proved that Riesz transforms characterize BMO. The next result is due to Uchiyama, who gave a criterion on families of Calderon-Zygmund operators to show if they generalize Stein-Fefferman decomposition. Then Li gave another criterion on those families of Calderon-Zygmund operators, to show if commutators characterize BMO. The first result in multiparameter case is due to Ferguson-Lacey, who proved in the case of parameter t=2 that Hilbert transform characterize BMO. Then Lacey and Terwilleger extended this result to arbitraly number of iterations. Finally, Lacey-Petermichl-Wick-Pipher extended this result to Riesz transform in product BMO space. So, first, I found a criterion on families of Calderon-Zygmund operators to know if they characterize product BMO space. Finally, I proved that commutators norms are majorized, up to a multiplicative constant, by BMO norm of b in multiparameter case for any kind of Calderon-Zygmund commutators, using the representation theorem of Hytonen, which reduces the problem to dyadic shifts
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Ortiz, Fernández Alejandro. "Casos Particulares de la desigualdad de John-Nirenberg para espacios BMO φ." Pontificia Universidad Católica del Perú, 2002. http://repositorio.pucp.edu.pe/index/handle/123456789/95513.
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Tinaztepe, Ramazan. "Modulation spaces, BMO and the Zak transform, and minimizing IPH functions over the unit simplex." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34659.
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This thesis consists of two parts. In the first chapter, we give some results on modulation spaces. First the relationship between the classical spaces and the modulation spaces is established. It is proved that certain modulation spaces defined on R² lie in the BMO space. Another result is that the Zak transform, a discrete time-frequency transform, maps a modulation space into a higher dimensional modulation space. And by using these results, an uncertainty principle for Gabor frames via modulation spaces is obtained.
In the second part, we deal with optimization of an increasing positively homogeneous functions on the unit simplex. The class of increasing positively homogeneous functions is one of the function classes obtained via min-type functions in the context of abstract convexity. The cutting angle method is used for the minimization of this type functions. The most important step of this method is the minimization of a function which is the maximum of a number of min-type functions on the unit simplex. We propose a numerical algorithm for the minimization of such functions on the unit simplex and we mathematically prove that this algorithm finds the exact solution of the minimization problem. Some experiments have been carried out and the results of the experiments have been presented.
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Zhang, Wenhao. "The Boundedness of the Hardy-Littlewood Maximal Function and the Strong Maximal Function on the Space BMO." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1907.
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In this thesis, we present the space BMO, the one-parameter Hardy-Littlewood maximal function, and the two-parameter strong maximal function. We use the John-Nirenberg inequality, the relation between Muckenhoupt weights and BMO, and the Coifman-Rochberg proposition on constructing A1 weights with the Hardy- Littlewood maximal function to show the boundedness of the Hardy-Littlewood maximal function on BMO. The analogous statement for the strong maximal function is not yet understood. We begin our exploration of this problem by discussing an equivalence between the boundedness of the strong maximal function on rectangular BMO and the fact that the strong maximal function maps A∞ weights into the A1 class. We then extend a multiparameter counterexample to the Coifman-Rochberg proposition proposed by Soria (1987) and discuss the difficulties in modifying it into an A∞ counterexample that would disapprove the boundedness of the strong maximal function.
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Gajek, Martin. "Filtrage de spin par des barrières multiferroïques." Paris 6, 2006. http://www.theses.fr/2006PA066565.
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MARQUET, HARRALD. "Etudes optiques et photothermiques des transferts de charges dans des sillenites (bmo). Role des centres pieges dans le photochromisme et effets de certains dopants." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13131.
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L'absorption extrinseque des sillenites non-dopes (bmo) est renforcee par une illumination (e > 2. 5 ev) a basse temperature (t < 280 k). Ce photochromisme peut se decomposer, dans le visible, en trois bandes centrees aux energies de 2. 3 ev, 2. 7 ev et 3. 05 ev. Ces bandes disparaissent en chauffant le cristal au-dessus de 300 k ou en l'eclairant avec une lumiere rouge (e < 2. 0 ev). La correlation des mesures de courant stimule thermiquement avec celles du blanchiment thermique du photochromisme nous a permis de proposer un mecanisme qui rend compte des observations experimentales et notamment de la stabilite thermique du photochromisme. Ce mecanisme est le suivant : des electrons libres sont crees soit par ionisation de centres donneurs profonds soit par des transitions bande a bande ; ces electrons peuplent des centres pieges a electrons peu profonds. Trois d'entre eux jouent le role de reservoirs a electrons pour un centre accepteur profond qui constitue l'etat fondamental des transitions photochromiques. Les etats excites sont situes dans la bande de conduction. Nous observons egalement que le peuplement des pieges peu profonds, sous l'effet d'un eclairement, est tres complexe. Nous montrons par ailleurs que les blanchiments optique et thermique sont differents d'un point de vue conceptuel : le mode thermique blanchit le cristal par depeuplement des pieges peu profonds tandis que le mode optique vide les etats accepteurs profonds. Ces deux techniques n'ont donc pas la meme efficacite. Les dopants agissent sur les densites de population des niveaux existants (profonds et superficiels) et creent dans certains cas de nouveaux centres pieges. Du depeuplement des centres donneurs profonds il resulte une diminution de l'intensite de l'absorption extrinseque et du photochromisme ; l'effet inverse est egalement observe. L'ajout de certains dopants tels cu, cr, cu+v permet de stabiliser le photochromisme jusqu'a tres haute temperature (680 a 720 k). Ces elements chimiques creent des niveaux reservoirs (pieges) tres profonds ( 1. 5 ev) que seules des temperatures tres elevees peuvent depeupler. Ces dopants presentent un interet technologique evident.
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Mei, Tao. "Operator valued Hardy spaces and related subjects." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4427.
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We give a systematic study of the Hardy spaces of functions with values in
the non-commutative Lp-spaces associated with a semifinite von Neumann algebra
M. This is motivated by matrix valued harmonic analysis (operator weighted norm
inequalities, operator Hilbert transform), as well as by the recent development of
non-commutative martingale inequalities. Our non-commutative Hardy spaces are
defined by non-commutative Lusin integral functions. It is proved in this dissertation
that they are equivalent to those defined by the non-commutative Littlewood-Paley
G-functions.
We also study the Lp boundedness of operator valued dyadic paraproducts and
prove that their Lq boundedness implies their Lp boundedness for all 1 < q < p < âÂÂ.
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Hauksson, Hilmar. "Metamodeling for Business Model Design : Facilitating development and communication of Business Model Canvas (BMC) models with an OMG standards-based metamodel." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-138139.
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Interest for business models and business modeling has increased rapidly since the mid-1990‘s and there are numerous approaches used to create business models. The business model concept has many definitions which can lead to confusion and slower progress in the research and development of business models. A business model ontology (BMO) was created in 2004 where the business model concept was conceptualized based on an analysis of existing literature. A few years later the Business Model Canvas (BMC) was published; a popular business modeling approach providing a high-level, semi-formal approach to create and communicate business models. While this approach is easy to use, the informality and high-level approach can cause ambiguity and it has limited computer-aided support available. In order to propose a solution to address this problem and facilitate the development and communication of Business Model Canvas models, two artifacts are created, demonstrated and evaluated; a structured metamodel for the Business Model Canvas and its implementation in an OMG standards-based modeling tool to provide tool support for BMC modeling.This research is carried out following the design science approach where the artifacts are created to better understand and improve the identified problem. The problem and its background are explicated and the planned artifacts and requirements are outlined. The design and development of the artifacts are detailed and the resulting BMC metamodel is presented as a class diagram in Unified Modeling Language (UML) and implemented to provide tool support for BMC modeling. A demonstration with a business model and an evaluation is performed with expert interviews and informed arguments.The creation of a BMC metamodel exposed some ambiguity in the definition and use of the Business Model Canvas and the importance of graphical presentation and flexibility in the tools used.The evaluation of the resulting artifacts suggests that the artifacts do facilitate the development and communication of the Business Model Canvas models by improving the encapsulation and communication of information in a standardized way and thereby the goals of the research are met.
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Kabbara, Sami. "Comparing Optical Coherence Tomography Radial and Cube Scan Patterns for Measuring Bruch’s Membrane Opening Minimum Rim Width (BMO-MRW) in Glaucoma and Healthy Eyes: Cross-sectional and Longitudinal Analysis." Thesis, The University of Arizona, 2018. http://hdl.handle.net/10150/627199.
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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.Background and Significance: Spectral Domain-Optical Coherence Tomography (OCT) is one of the most widely used imaging modality in Ophthalmology. It utilizes light waves to visualize the various layers of the retina. The OCT machines offer two different scan patterns, the circular and the cube scan patters. It is important to compare these scan pattern to see if any discrepancy exist in quantifying retinal indices. One of the newer indices is the Bruch’s membrane opening minimum rim width (BMO-MRW), which is the minimum distance between from the BMO to the inner limiting membrane (ILM). The BMO-MRW is being used in the diagnosis of glaucoma. Hypothesis: To compare the cube and radial scan patterns of the SD-OCT for quantifying the BMO-MRW. We hypothesis that there might be some differences between the two scan patterns.
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Samoyeau, Valentin. "Autour des inégalités de dispersion via le semi-groupe de la chaleur." Nantes, 2016. https://archive.bu.univ-nantes.fr/pollux/show/show?id=e927d110-51ec-469a-b3ce-39c664e925fa.
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Dans cette thèse, on s’intéresse aux propriétés du semi-groupe de la chaleur qui assurent de retrouver des inégalités de Strichartz dans un cadre général. Plus précisément, on considère un espace métrique muni d’une mesure doublante et équipé d’un opérateur auto-adjoint positif qui engendre un semi-groupe. Le semi-groupe est dit de la chaleur puisqu’on suppose qu’il vérifie des estimations Gaussiennes et de Davies-Gaffney typiques. Dans un premier temps on définit des espaces de Hardy et BMO associés au semi-groupe et on prouve que l’on peut interpoler avec les espaces de Lebesgue usuels. En adaptant les outils classiques de la théorie de Littlewood-Paley au semi-groupe de la chaleur on démontre des estimations de dispersion Lp − Lp’ p p ϵ ((1, 2) et des inégalités de Strichartz à partir d’estimations de dispersion H1 − BMO. On montre ensuite que l’on peut ramener cette estimation H1 − BMO à une estimation microlocalisée L2 − L2. Une étude des phénomènes de dispersion pour le propagateur des ondes selon les régions du cône de lumière permet de prouver ces estimations L2 − L2. Les différents résultats de ce travail mettent en lumière les liens entre la dispersion pour l’équation des ondes et la dispersion pour l’équation de Schrödinger. On donne ainsi une méthode unifiée pour obtenir des estimations de dispersion et des inégalités de Strichartz dans un cadre, associé au semi-groupe de la chaleur, très généralIn this PhD thesis, we are interested in properties of a heat semigroup that ensure to recover Strichartz estimates in a general framework. More precisely, we consider a metric space with a doubling measure, equipped with a nonnegative self-adjoint operator generating a semigroup. The semigroup is said to be a heat semigroup since we assume that it satisfies typical Gaussian and Davies-Gaffney estimates. Firstly we define Hardy and BMO spaces associated with the semigroup and prove that we can interpolate with the usual Lebesgue spaces. By an adaptation of the classical tools of Littlewood-Paley theory to the heat semigroup setting, we show Lp − Lp’ destimates for p ϵ ((1, 2) and Strichartz inequalities from a H1 − BMO dispersive estimate. We then prove that this estimate can be reduced to microlocalized L2 − L2 one. A study of the dispersive phenomena for the wave propagator according to the region of the light cone allows to prove those L2 − L2 estimates. The different results of this work highlight the connections between dispersion for the wave equation and dispersion for Schrödinger equation. Thus we propose a new and unified way to prove dispersive estimates and Strichartz inequalities in a very abstract setting, adapted to a heat semigroup
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Berdan, Nada El. "Régularité de problèmes à données dans les espaces pondérés par la distance au bord via l'inégalité uniforme de Hopf et le principe de dualité." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2303/document.
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Cette thèse, comporte deux parties distinctes.Dans la première partie, on étudie l'existence et l'inexistence d'une inégalité qu'on a appelée l'inégalité de Hopf Uniforme (IHU), pour une équation linéaire de la forme Lv = f à coefficients bornés mesurables et sous les conditions de Dirichlet homogènes. L'IHU est une variante du principe de maximum, on l'a appliquée dans la preuve de la régularité W1;p 0 pour un problème semi-linéaire singulier : Lu = F(u) où les coefficients de L sont dans l'espace vmor (fonctions à oscillation moyenne évanescente) et F(u) est singulier en u = 0 F(0) = +∞. De plus, si les coefficients sont lipschitziens, on prouve que la régularité optimale du gradient de la solution u est bmor (fonctions à oscillation moyenne bornée i.e Grad u dans bmor).Dans la seconde partie, on s'intéresse à la régularité du système d'élasticité (équations stationnaires des ondes élastiques) avec une fonction source singulière au sens qu'elle n’est qu'intégrable par rapport à la fonction distance au bord du domaine. Via la dualité, nous montrons, selon ~f , que le problème admet une solution dite très faible dont le gradient n'est pas nécessairement intégrable sur tout le domaine mais uniquement localement. Nous déterminons aussi les fonctions vectorielles ~f pour lesquelles, ~u a son gradient intégrable sur tout l'espace de travailWe discuss the existence and non existence of the so called Hopf uniform Inequality (variant of a maximum principle) for the linear equation Lv = f with measurable coefficients and under the homogeneous Dirichlet Boundary condition. Then we apply such inequality to prove the W1;p 0 -regularity of a semi linear problem Lu = F(u), singular at u = 0, with the coefficients of the main operator of L in the space of vanishing mean oscillation. Moreover, when those coefficients are Lipschitz, we show that the gradient of the solution is at most in the space of bounded mean oscillation : bmor. In the last part of this thesis, we are concerned with the linear easticity system (Stationnary equation of the waves elasticity). But, here the second terms varies with respect to the distance function until the boundary.Using the duality method, we study the regularity of the solution of the elasticity system for the data belonging to various weighted spaces
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Yin, Zhi. "Espaces de Hardy en probabilités et analyse harmonique quantiques." Phd thesis, Université de Franche-Comté, 2012. http://tel.archives-ouvertes.fr/tel-00838496.
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Cette thèse présente quelques résultats de la théorie des probabilités quantiques et de l'analyse harmonique à valeurs operateurs. La thèse est composée des trois parties.Dans la première partie, on démontre la décomposition atomique des espaces de Hardy de martingales non commutatives. On identifie aussi les interpolés complexes et réels entre les versions conditionnelles des espaces de Hardy et BMO de martingales non commutatives.La seconde partie est consacrée à l'étude des espaces de Hardy à valeurs opérateursvia la méthode d'ondellettes. Cette approche est similaire à celle du cas des martingales non commutatives. On démontre que ces espaces de Hardy sont équivalents à ceux étudiés par Tao Mei. Par conséquent, on donne une base explicite complètement inconditionnelle pour l'espace de Hardy H1(R), muni d'une structure d'espace d'opérateurs naturelle. La troisième partie porte sur l'analyse harmonique sur le tore quantique. On établit les inégalités maximales pour diverses moyennes de sommation des séries de Fourier définies sur le tore quantique et obtient les théorèmes de convergence ponctuelle correspondant. En particulier, on obtient un analogue non commutative du théorème classique de Stein sur les moyennes de Bochner-Riesz. Ensuite, on démontre que les multiplicateurs de Fourier complètement bornés sur le tore quantique coïncident à ceux définis sur le tore classique. Finalement, on présente la théorie des espaces de Hardy et montre que ces espaces possèdent les propriétés des espaces de Hardy usuels. En particulier, on établit la dualité entre H1 et BMO.
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Zinsmeister, Michel. "Domaines de Lavrentiev." Paris 11, 1985. http://www.theses.fr/1985PA112241.
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Cette thèse présente tout d’abord les principales propriétés de la représentation conforme d’un domaine Ω simplement connexe du plan dont le bord Γ est une courbe rectifiable régulière au sens d’Ahlfors. Cette étude permet de munir l’ensemble L des domaines de Lavrentiev d’une structure analytique complexe analogue à celle de l’espace universel de Teichmüller l’espace de Banach sous-jacent étant ici BMO. L’opérateur de Cauchy C opérant sur L²(Γ,ds) apparaît alors comme dépendant analytiquement de Γ E L. Dans une deuxième partie, on étudie le problème de Neuman pour les domaines de Jordan rectifiables. On caractérise géométriquement les domaines pour lesquels ce problème peut se résoudre dans un Lp(Γ,ds) (p > 1). On construit également, pour tout p > 1, un domaine de Laventriev pour lequel on ne peut résoudre le problème de Neuman dans Lp. Enfin, certains analogues quasiconformes sont établis, permettant d’ébaucher une théorie en dimension supérieureThis thesis presents first the principal properties of the conformal mapping of a simply connected domain Ω whose boundary Γ is regular in Ahlfor’s sense. This permits to put a complex analytic structure on L, the set of Lavrentiev’s domains, similar to the universal Teichmüller space, the underlying Banach space being here BMO. The Cauchy operator CΓ, operating on L²(Γ,ds) is then seen to depend analytically on Γ E L. In a second part we study Neuman problem for rectifiable Jordan domains. We characterize those domains for which one can solve this problem with data in an Lp(Γ,ds) (p > 1). We also construct, for each p > 1, a Lavrentiev domain for which one cannot solve Neuman problem with Lp-data. In the last chapter we establish some quasiconformal analogues of the theory, permitting us to prepare a n-dimensional theory
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Carmical, Jennifer, and Stacy D. Brown. "The Impact of Phospholipids and Phospholipid Removal on Bioanalytical Method Performance." Digital Commons @ East Tennessee State University, 2016. https://doi.org/10.1002/bmc.3686.
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Phospholipids (PLs) are a component of cell membranes, biological fluids and tissues. These compounds are problematic for the bioanalytical chemist, especially when PLs are not the analytes of interest. PL interference with bioanalysis highly impacts reverse-phase chromatographic methods coupled with mass spectrometric detection. Phospholipids are strongly retained on hydrophobic columns, and can cause significant ionization suppression in the mass spectrometer, as they out-compete analyte molecules for ionization. Strategies for improving analyte detection in the presence of PLs are reviewed, including in-analysis modifications and sample preparation strategies. Removal of interfering PLs prior to analysis seems to be most effective at moderating the matrix effects from these endogenous cellular components, and has the potential to simplify chromatography and improve column lifetime. Products targeted at PL removal for sample pre-treatment, as well as products that combine multiple modes of sample preparation (i.e. Hybrid SPE), show significant promise in mediating the effect on PL interference in bioanalysis.
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Pickering, Matthew K., and Stacy D. Brown. "Assays for Determination of Ertapenem for Applications in Therapeutic Drug Monitoring, Pharmacokinetics, and Sample Stability." Digital Commons @ East Tennessee State University, 2014. https://doi.org/10.1002/bmc.3301.
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Carbapanems are a class of β-lactam antibiotics with broad-spectrum potency and high β-lactamase resistance. Ertapenem, a member of this class, sold under the trade name Invanz™, has been of interest in the world of antibiotic therapeutic drug monitoring owing to its highly standardized 1 g dose and its high degree of plasma protein binding. Owing to the relative newness of this drug, fewer than 30 methods for ertapenem quantification have been published. Among these about half utilize biological matrices at the sample type. Liquid-liquid extraction and protein precipitation prevail as the most frequently used sample preparation techniques, despite their low recoveries compared with solid-phase extraction. Additionally, high-performance liquid chromatography with ultraviolet detection (HPLC-UV) is the instrumentation choice for most ertapenem assays. While these approaches may not achieve the highest possible sensitivity for ertapenem quantification, they provide clinically relevant tools for monitoring ertapenem in real patients. Sample stability is an ongoing concern for laboratories that handle ertapenem analysis, with buffering being of paramount importance, as well as low temperature (
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Kyle, Amy Redmond, Jennifer Carmical, Darshan Shah, Jason Pryor, and Stacy D. Brown. "UHPLC-MS/MS Quantification of Buprenorphine, Norbuprenorphine, Methadone, and Glucuronide Conjugates in Umbilical Cord Plasma." Digital Commons @ East Tennessee State University, 2015. https://doi.org/10.1002/bmc.3460.
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Opioid use during pregnancy can result in the newborn being physically dependent on the substance, thus experiencing drug withdrawal, termed neonatal abstinence syndrome (NAS). Buprenorphine and methadone are two drugs used to treat opioid withdrawal and are approved for use in pregnancy. Quantification of these compounds in umbilical cord plasma would help assess in utero exposure of neonates in cases of buprenorphine or methadone use during pregnancy. An LC-MS/MS method using solid-phase extraction sample preparation was developed and validated for the simultaneous quantification of methadone, buprenorphine, norbuprenorphine, and glucuronide metabolites in umbilical cord plasma. The average accuracy (percentage error) and precision (relative standard deviation) were
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Combs, Carolyn C., Erin L. Hankins, Cara L. Copeland, Stacy D. Brown, and Brooks B. Pond. "Quantitative Determination of D- and L- Enantiomers of Methylphenidate in Brain Tissue by Liquid Chromatography-Mass Spectrometry." Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1002/bmc.2975.
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Methylphenidate, a psychostimulant used for the treatment of attention deficit hyperactivity disorder and narcolepsy, is administered as a 50:50 racemic mixture, despite the fact that d‐methylphenidate has been shown to have greater pharmacologic activity. This paper presents a validated LC‐MS/MS approach to separation and quantification of methylphenidate enantiomers using a vancomycin column and triethylammonium acetate to enhance the chiral separation. The method is applicable to the monitoring of these enantiomers in mouse brain, with a limit of detection of 0.5 ng/mL and a lower limit of quantification of 7.5 ng/mL.
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Archibald, Timothy L., Derek Edward Murrell, and Stacy D. Brown. "Chromatographic Methods in Hiv Medicine: Application to Therapeutic Drug Monitoring." Digital Commons @ East Tennessee State University, 2018. https://doi.org/10.1002/bmc.4170.
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HIV antiretroviral therapy spans several different drug classes, meant to combat various aspects of viral infection and replication. Many authors have argued the benefits of therapeutic drug monitoring (TDM) for the HIV patient including compliance assurance and assessment of appropriate drug concentrations; however, the array of drug chemistries and combinations makes TDM an arduous task. HPLC-UV and LC-MS/MS are both frequent instruments for the quantification of HIV drugs in biological matrices with investigators striving to balance sensitivity and affordability. Plasma, the dominant matrix for these analyses, is prepared using protein precipitation, liquid-liquid extraction or solid-phase extraction depending on the specific complement of analytes. Despite the range of polarities found in drug classes relevant to HIV therapeutics, most chromatographic separations utilize a hydrophobic column (C18 ). Additionally, as the clinically relevant samples for these assays are infected with HIV, along with possible co-infections, another important aspect of sample preparation concerns viral inactivation. Although not routine in clinical practice, many published analytical methods from the previous two decades have demonstrated the ability to conduct TDM in HIV patients receiving various medicinal combinations. This review summarizes the analytical methods relevant to TDM of HIV drugs, while highlighting respective challenges.
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Brown, Stacy D., and Tyler C. Melton. "Trends in Bioanalytical Methods for Club Drugs: 2000-2010." Digital Commons @ East Tennessee State University, 2011. https://doi.org/10.1002/bmc.1549.
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The term 'club drug' can be loosely defined as any substance used to enhance social settings. Such drugs are commonly found at raves or similar all-night dance parties and include methamphetamine, 3,4-methylenedioxymethamphetamine, gamma-hydroxybutyrate (GHB), ketamine (KET), and flunitrazepam (FLU). These drugs have potentially dangerous side effects including hallucinations, paranoia, amnesia and hyperthermia. In addition, GHB, KET and FLU are considered predatory drugs due to their roles in drug-facilitated sexual assault. Forensic and regulatory agencies routinely have the need for determination and accurate quantification of these drugs in biological fluids, especially in cases of mortality or criminal investigations. This review presents the chromatographic and spectroscopic methods published for such analyses over the last decade, including sample preparation techniques and validation data.
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Carvalho, Jesiel Freitas. "Crescimento e caracterização de monocristais fotorreativos: BSO e BTO." Universidade de São Paulo, 1994. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-14012009-093345/.
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Neste trabalho crescemos monocristais de Bi12SiO20 (BSO) e de Bi12TiO20 (BTO). Os cristais de BSO foram crescidos pela técnica de Czochralski a partir da fase líquida com composição molar 6Bi2O3:1SiO2. Os melhores resultados foram obtidos para taxas de puxamento entre 1 e 2,5mm/h, a velocidade de rotação foi mantida constante em 20rpm. Os cristais de BTO foram crescidos pelo método top-seeded solution Growth (TSSG) a partir da composição molar 10Bi2O3:1SiO2, com taxas de puxamento menores que 0,3mm/h e velocidade de rotação entre 16 e 30 rpm. A qualidade dos cristais foi avaliada utilizando microscopia óptica e eletrônica, corrosão seletiva e raios-x. Por microscopia óptica identificamos os defeitos macroscópicos e discutimos sua natureza e possíveis causas. Utilizando a técnica de ataque químico seletivo, analisamos a morfologia das figuras de ataque e estimamos a densidade de deslocações. Visando identificar defeitos de estequiometria, fizemos medidas de composição por microanálise eletrônica. Para a caracterização cristalográfica, calculamos o parâmetro de rede por difração de raios-x usando o método do pó e confirmamos a estrutura cristalográfica através do método de Rietveld. E, ainda, medimos a atividade óptica que é uma constante característica dos cristais.In this work we grew Bi12SiO20 (BSO) and Bi12TiO20 single crystals. The BSO crystals have been grown from the melt composition of 6Bi2O3:1SiO2 by the Czochralski method. The best results were obtained at pulling rates from 1 to 2.5m/h, the rotation rate of 20rpm was constant. The BTO crystals have been grown by the top-seeded solution growth technique from a 10Bi2O3:1SiO2 solution with pulling rates less than 0.3mm/h and rotation rates from 16 to 30rpm. The crystal quality was examined by optical and scanning electron microscopy, selective etching, and x-ray diffraction. We identified the macroscopic defects by optical microscopy and discussed their nature and probable origin. Using selective etching, we analyzed the etching pits morphology and evaluated the dislocation density. To identify stoichiometric defects, composition measurements by electron probe microanalysis were made. To obtain crystallographic characterization, we calculated the cell parameter by powder method x-ray diffraction and used the Rietveld method to verify the crystallographic structure. And, also, we measured the optical activity, a constant of the crystals.
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Hong, Guixiang. "Quelques problèmes en analyse harmonique non commutative." Phd thesis, Université de Franche-Comté, 2012. http://tel.archives-ouvertes.fr/tel-00979472.
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Cette thèse présente quelques résultats de la théorie des probabilités quantiques et de l'analyse harmonique non commutative. Elle est constituée de trois parties. La première partie démontre l'analogue non commutatif de l'inégalité de John-Nirenberg et la décomposition atomique pour les martingales non commutatives. Ces résultats étendent et améliorent ceux qui existent déjà, et correspondent exactement à ceux que l'on connaît dans le cas classique. La deuxième partie est consacrée à l'étude des espaces de Hardy à valeurs opérateurs via la méthode d'ondelettes. Il est montré que les espaces de Hardy définis par ondelettes coïncident avec ceux définis par les fonctions carrées de Littlewood-Paley et Lusin. Cette approche est similaire à celle du cas des martingales non commutatives, mais l'utilisation des outils de martingales en analyse harmonique permet une démonstration plus rapide. Dans la troisième partie, nous nous tournons vers des applications de la théorie bien établie des espaces de Hardy, c'est-à-dire des opérateurs de Calderón-Zygmund (OCZ pour abréviation) associés à des noyaux à valeurs matricielles. On obtient des estimations de type faible (1, 1) pour des OCZ dyadiques parfaites et des shifts de Haar annulateurs associés à des noyaux non commutatifs, ainsi que des estimations de type H1 → L1 pour des OCZ arbitaires d'après une décomposition d'une fonction en ligne/colonne. En conjonction avec L∞ → BMO, nous établissons certaines estimations de type Lp. Cette approche s'applique aussi à des paraproduits et des transformées de martingales avec des symboles et coefficients non commutatifs respectivement.
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Valencia, M. Nicolás. "Estación metamodal Bio Bio." Tesis, Universidad de Chile, 2013. http://www.repositorio.uchile.cl/handle/2250/116944.
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ArquitectoDefinido como instrumento de implementación de la próxima Política Nacional de Transporte, el actual plan interministerial de movilidad para el Gran Santiago (PMTS 2025) considera más de 20 iniciativas públicas y privadas entre Metro, tranvías, trenes interurbanos, ciclovías, corredores Transantiago y un teleférico, totalizando 45 potenciales nodos intermodales en 17 comunas santiaguinas. Esta inversión es una oportunidad para reflejar una nueva relación dialéctica entre transporte y espacio urbano, a través del replanteamiento de la concepción y diseño de infraestructuras multimodales, abordando así su actual desconexión de la estructura urbana en la que se insertan y anticipando posibles consecuencias en las dinámicas locales de desarrollo. En el barrio Biobío se proyectaría una combinación intermodal entre la metroestación homónima (L6) y la línea de pre-Metro trazada por el eje Santa Rosa, convirtiendo al sector, a través de este eje metropolitano, en portal de acceso sur a la comuna capital. Asimismo, se advierte una nula protección normativa del barrio, fortaleciendo las expectativas de densificación residencial de municipios adyacentes y especulaciones inmobiliarias detenidas desde avenida Matta hacia el sur, amenazando la reconocida identidad comercial y social del barrio. Este escenario motiva a plantear una Estación Metamodal (“una interconexión más allá de los modos”, como se explicará) desglosada en tres escalas de acción (predio, radio de influencia y hemisferios), debido al impacto e influencia recíproca tanto en las dinámicas de desarrollo como en los patrones de desplazamientos (inter)locales. La propuesta arquitectónica propiamente tal consiste en el reacondicionamiento de un centenario galpón y sus predios contiguos, a intervenir bajo estrategias de diseño inspiradas en las decisiones locales de ocupación comercial de galpones y galerías interiores, y reconociendo la jerarquía de los flujos locales categorizados (vitrineo/conexión). Más allá de los clichés, ambos reflejan el patrimonio intangible local. Asimismo, la Estación también sumará metraje comercial y suplirá la carencia de espacios públicos de ocio (simultáneidad, temporalidad y diversidad) y suturará ambos hemisferios del barrio -amenazados por el corredor Transantiago Santa Rosa-, definiendo estrategias preliminares de intervención urbanística y de estructuración vial.
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Mosher, Scott C. "AN INVESTIGATIVE STUDY INTO THE RELATIONSHIP OF BONE MORPHOGENETIC PROTEIN ANTAGONIST EXPRESSION AND OSTEOCYTE DENSITY BY REGION AND QUADRANT." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/279.
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The role of cytokines and cell behavior and viability with respect to bone remodeling and bone behavior is an exciting area of orthopedic research. The purpose of this study was to investigate the relationships between BMP antagonist expression and osteocyte density, lacunar densities and osteocyte viability in cortical bone. Samples of unloaded tibial bone obtained from six C57Bl/6 mice were immunohistochemically stained for gremlin and noggin expression and also underwent methyl green staining to determine osteocyte presence. Bone sections were divided into four quadrants (cranial, caudal, medial and lateral) and three regions (proximal, mid shaft and distal), followed by analysis across these quadrants and regions. The results showed matching regional differences in gremlin expression with regional variations in osteocyte density, lacunar density, and osteocyte viability. These variations were supported by positive correlations found via regression analysis. Regression analysis also showed marginal negative correlations between noggin expression and osteocyte density and osteocyte viability, supported by regional ANOVA results. Further research on loaded bone samples is needed if the relationship between these BMP antagonists and osteocyte densities are to be fully explained with respect to the bone remodeling process.
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zhou, jingran. "a Bayesian test of independence of two categorical variables obtianed from a small area : an application to BMD and BMI." Digital WPI, 2011. https://digitalcommons.wpi.edu/etd-theses/1129.
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"Scientists usually need to understand the extent of the association of two attributes, and the data are typically presented in two-way categorical tables. In science, the chi-squared test is routinely used to analyze data from such tables. However, in many applications the chi-squared test can be defective. For example, when the sample size is small, the chi-squared test may not be applicable. The terms small area" and local area" are commonly used to denote a small geographical area, such as a county. If a survey has been carried out, the sample size within any particular small area may be too small to generate accurate estimates from the data, and a chi-squared test may be invalid (i.e., expected frequencies in some cells of the table are less than ?ve). To deal with this problem we use Bayesian small area estimation. Because it is used toorrow strength" from related or similar areas. It enhances the information of each area with common exchangeable information. We use a Bayesian model to estimate a Bayes factor to test the independence of the two variables. We apply the model to test for the independence between bone mineral density (BMD) and body mass index (BMI) from 31 counties and we compare the results with a direct Bayes factor test. We have also obtained numerical and sampling errors; both the numerical and sampling errors of our Bayes factor are small. Our model is shown to be much less sensitive to the speci?cation of the prior distribution than the direct Bayes factor test which is based on each area only."
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Graholski, Stefan. "Energieffektivisering för trådlöst mätande av rotationshastighet." Thesis, Mittuniversitetet, Institutionen för elektronikkonstruktion, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-39599.
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Energy efficiency has made great progress in today’s technologies to contribute to a better environment and increasingly sustainable energy system. In this work will the biggest focus be to make the rotational speed sensor more energy efficient. The overall purpose in this work is to see if the implementation of the SparkFun RedBoard Artemis card together with the Bosch BMI 270 gyro sensor could be an energy efficient system to respect of the Bosch BMG-250 gyroscope and the Rigado BMD-350 development board that has been used in a previous work. In the report was a method used to measure the current and energy consumption that occurred when the development board and gyroscope sensor was working. In this method did also a analyze went for to see if a difference occurred at current and energy consumption of the development card when the complete system was communicating with eighter I2C or SPI communication. Another method that has performed in this work, was to see how much current that has been consumed when a varying amount data that have used the buffer of the Bluetooth module. The result from this work showed that the SparkFun RedBoard Artemis development card together with the Bosch BMI-270 gyroscope sensor did consume considerably more energy compared to the result that was expressed in the previous work. Also did the result show that the current consumption was the same regardless to how much data that was used in the Bluetooth modules buffer. The work concluded that the development card SparkFun RedBoard Artemis together with the Bosch BMI-270 MEMS gyroscope sensor would not be imagine to be an energy efficient system regardless to the units that was used in the previous work.Energieffektiviteten har gjort stora framsteg inom dagens teknologier för att bidra till en bättre miljö och allt mer hållbart energisystem. Inom detta arbete läggs störst fokus på att energieffektivisera ett inbyggt sensorsystem som används för att trådlöst mäta rotationshastigheter. Det övergripande syftet för arbetet är att se om implementeringen av SparkFun RedBoard Artemis kortet tillsammans med Bosch BMI 270 gyrosensorn skulle kunna vara ett energieffektivt system till avseendet av gyroskopsensorn Bosch BMG-250 och utvecklingskortet Rigado BMD-350 som användes inom ett tidigare arbete. I rapporten användes en metod för att mäta fram den ström samt energikonsumtion som förekommer när utvecklingskortet och gyrosensorn arbetar. Inom denna metod undersöktes det även om det förekom någon skillnad på utvecklingskortets ström samt energiförbrukning när den kompletta konstruktionen kommunicerar med antingen I2C eller SPI kommunikation. Ytterligare en metod som utfördes inom detta arbete var för att se hur mycket ström som konsumeras när en varierande mängd data utnyttjar Bluetooth modulens buffert. Resultaten från arbetet visade att SparkFun RedBoard Artemis kortet tillsammans med Bosch BMI 270 gyrosensorn konsumerade mer energi jämfört med det resultat som framfördes inom det tidigare arbetet. Det visade sig även att systemets strömkonsumtion blev detsamma oavsett hur mycket data som utnyttjade Bluetooth modulens buffert. Arbetets slutsats besvaras med att SparkFun RedBoard Artemis kortet tillsammans med Bosch BMI-270 MEMS gyroskopsensorn inte skulle tänka sig vara ett mer energieffektivt system jämfört med de enheterna som användes inom det tidigare arbetet.
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Rahikainen, Mika. "Evaluation and management of the Finnish herring fishery." Helsinki : University of Helsinki, 2005. http://ethesis.helsinki.fi/julkaisut/bio/bioja/vk/rahikainen/evaluati.pdf.
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Thesis (Doctoral)--Helsingin yliopisto, 2005.Tiivistelmäosa ja 5 julkaisua Includes bibliographical references. Saatavana myös elektronisena (ISBN 952-10-2740-1 pdf), Available in PDF format via the World Wide Web. http://ethesis.helsinki.fi
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Jiao, Chaoying. "Miscible displacements in porous media with variation of fluid density and viscosity /." [Karlsruhe] : Die Universität, 2001. http://www.ubka.uni-karlsruhe.de/vvv/2002/bio-geo/1/.
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Thesis (Doctoral)--Universität Karlsruhe, 2001.Abstract in German. Hochschulschrift = Thèse/Mémoire. Includes bibliographical references (p. 109-133). Also available via the World Wide Web. http://www.ubka.uni-karlsruhe.de/indexer-vvv/2002/bio-geo/1
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Gordon, Christal. "Bio-inspired, bio-compatible, reconfigurable analog CMOS circuits." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37222.
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This work details CMOS, bio-inspired, bio-compatible circuits which were used as synapses between an artificial neuron and a living neuron and between two living neurons. An intracellular signal from a living neuron was amplified, an integrate-and-fire neuron was used as a simple processing element to detect the spikes, and an artificial synapse was used to send outputs to another living neuron.
The key structure is an electronic synapse which is based around a floating-gate pFET. The charge on the floating-gate is analogous to the synaptic weight and can be modified. This modification can be viewed as similar to long-term potentiation and long-term depression. The modification can either be programmed (supervised learning) or can adapt to the inputs (unsupervised learning). Since the technology to change the floating-gate weight has greatly improved, these weights can be set quickly and accurately. Intrinsic floating-gate learning rules were explored and the ability to change the synaptic weight was shown.
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Karapa, Eleni. "Bio-membranes : a bio-logical approach to architecture." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1033631.
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Bio-membranes: A Biological Approach to Architecture The desire to introduce an area of study which can potentially inform the field of architecture on a theoretical as well as on a practical level, is the primary aim of this creative project. More specifically, the interest of this work is focused on the identification of useful processes deriving from the world of biology and their utilization in the world of architecture. The designation of an alternative path for perceiving and understanding processing and principles that may be of use in the reconfiguration of various architectural design applications is in quest. In search of a biological model that can potentially inform the field of architecture and provide enough feedback concerning the understanding of "processing" and "principles", biomembrane systems have been designated as the appropriate subject of study. The study and analysis of the structural and functional aspects of the bio-membranes as well as the extraction of useful principles that are derived from this study consist the first part of this work. The second part describes the implementation of these principles into various architectural applications while it challenges existing paradigms and introduces new ways of looking into the realm of architectural theory.Department of Architecture
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Sosna, Dieter. "Bio-Datenbanken." Universität Leipzig, 2008. https://ul.qucosa.de/id/qucosa%3A32207.
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Kafmann, Simon. "BMW iSPACE." Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171727.
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Architecture and mobility merge together to provide space for activities away from both home and office. The densification of people’s living space and the delocalisation of the workplace are two of the biggest emerging trends in the near future. Society is constantly changing with new needs and desires. The Internet of Things, new technologies and possibilities of autonomous driving enable new approaches to redesign the traditional car. The aim of this project is to rethink mobility and especially the car as we know it today. Since it has been shown that cars are no longer used exclusively as a means of transport, but also as mobile space, the image of the car as people know it could be redrawn Since BMW i is an innovative brand, which can break new ground, it can be ahead of its time and lead society instead of following it. After the first research and examination of relevant topics, the results were further developed and worked out. The system in which the concept takes place is defined in more detail based on further investigations such as scenario, marketplace and target group. The focus is mainly on the interior and exterior of the vehicle. In addition, an insight into the inspiration and the process of aesthetic design is described and illustrated in several sketches and renderings. Then the further development in 3D and VR (Virtual Reality) is shown up to the final digital model. iSpace is a system that brings attention to the potential new role of the car in the coming years. iSpace is rather a mobile architecture than a conventional car, which means that it is used in a completely new and fresh way. The vehicle is designed to be used mainly in the static mode and offers the possibilities of a mobile space to support the flexible and delocalised lifestyle of people. In that sense it shows a completely new view how a vehicle could look like, while creating new kind of benefits to enrich and improve the quality of life. iSpace is part of a bigger system containing several vehicles to cover different types of needs and HUBs, which are the extension of the vehicles to various locations in urban areas.
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Gouveia, Carolina Teixeira de Sousa. "Bio-Radar." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/23811.
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Mestrado em Engenharia Eletrónica e TelecomunicaçõesNesta dissertação é desenvolvido um protótipo de um bio-radar, cujo foco é a aquisição e processamento do sinal respiratório em tempo real. O sistema do bio-radar permite medir sinais vitais com precisão, baseando-se no princípio do efeito Doppler, que relaciona as propriedades do sinal recebido com a variação da distância percorrida desses sinais. Essa distância está compreendida entre as antenas do radar e a caixa torácica do paciente. No contexto deste projeto, é apresentado o modelo matemático do bio-radar e é também desenvolvido um algoritmo que visa extrair o sinal respiratório tendo em consideração a sensibilidade dos sinais envolvidos tal como o modo de operação do sistema. O protótipo em tempo real desenvolvido nesta dissertação usa um front-end baseado em Software Defined Radio (SDR) e os sinais por ele adquiridos são processados no software LabVIEW da National Instruments.
In this dissertation, a prototype of a bio-radar was developed with focus in the real-time acquisition and processing of the respiratory signal. The bio-radar system can measure vital signals accurately by using the Doppler e ect principle that relates the received signal properties with the distance change between the radar antennas and the person's chest-wall. In this framework, a mathematical model of the bio-radar is presented. Also, an algorithm for respiratory rate extraction is proposed having in mind the acquired signal's sensitivity and the system's operation. The real-time acquisition system is developed using a front-end based in SDR and the acquired signals are processed using the LabVIEW software from National Instruments.
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Cuzcano, Loayza Brenda Sofía, Sandoval Gustavo Antonio Manchego, Carhuapuma Jahayra Xiomara López, and Fernadez Pamela Jackeline Venegas. "Dolce Bio." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/652209.
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El presente proyecto es un producto natural para personas con un estilo de vida saludable e intolerantes a la lactosa, este cuenta con viabilidad en su desarrollo, debido a la investigación realizada, en el que se segmenta a la población de Lima Metropolitana de los niveles socioeconómicos A, B y C, donde se valida un alto interés por el producto y la falta de una bebida 100% natural deslactosada y con un sabor agradable en el mercado. Asimismo, se reconoció que las personas cuentan con poca disponibilidad de tiempo para preparar sus alimentos, debido a las actividades que realizan en el día, por lo que, recurren mayormente a productos prácticos en el momento de su alimentación. Además, existe una creciente demanda de alimentos saludables y naturales, debido al incremento de personas que adoptan un estilo de vida saludable. Por último, las personas intolerantes a la lactosa cuentan con pocas alternativas de productos alimenticios y de sabor agradables en el mercado.
Para que este proyecto se lleve a cabo, se realizó un estudio de mercado que involucró, en primer lugar, al consumidor, proveedores y distribuidores. También se analizó el proceso de cadena de valor para el negocio, para lo cual se tomó en cuenta la aplicación de estrategias operacionales, de responsabilidad social, de marketing y de desarrollo financiero, que tienen por finalidad mantener la rentabilidad y viabilidad del proyecto a largo plazo en el mercado. De este modo, la inversión para ejecutar este proyecto sería de S/ 9,881.54, con el que se obtendrá una utilidad neta de S/ -18,869.00 en el primer año, -S/ 62,426.00 en el segundo año y -S/80,670.00 en el tercer año.The present project is a natural product for people with a healthy lifestyle and lactose intolerant, it has a feasibility in its development, due to the research carried out, in which the population of Metropolitan Lima is segmented from socioeconomic levels A, B and C, which validates a high interest in the product and the lack of a 100% natural drink lactose and with a pleasant taste in the market. Likewise, it was recognized that people have little availability of time to prepare their food, due to the activities they carry out during the day, so they use mostly practical products at the time of feeding. In addition, there is a growing demand for healthy and natural foods, due to the increase in people adopting a healthy lifestyle. Finally, lactose intolerant people have few alternatives for food and taste products that are pleasant in the market. For this project to be carried out, a market study was carried out that involved, first, the consumer, suppliers and distributors. The value chain process for the business was also analyzed, for which the application of operational, social responsibility, marketing and financial development strategies was taken into account, which aim to maintain the profitability and viability of the project over the long term. term in the market. In this way, the investment to execute this project would be S /S/ 9,881.54, with which a net profit of -S/ 18,869.00 will be obtained in the first year, -S/ 62,426.00in the second year and -S/80,670.00 in the third year.
Trabajo de investigación
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Sakaguchi, Masakazu. "Gasification of bio-oil and bio-oil/char slurry." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23347.
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Economic utilization of biomass as a fuel has been limited by transportation cost. One suggested remedy to address the problems of processing biomass on a large scale is to pyrolyze solid biomass at numerous local sites and transport the resulting liquid or liquid/char slurry to a large centralized conversion plant. This research involves the gasification of biomass fast pyrolysis oil, so called bio-oil, and a slurry mixture of bio-oil and fast pyrolysis char into synthesis gas.
Kinetics of the reaction of steam with chars was studied using a thermo-gravimetric analyzer. Slurry Char was produced by pyrolysis of an 80 wt% bio-oil/20 wt% char mixture at nominal heating rates of 100–10,000°C/s. The resulting Slurry Char was subjected to steam gasification with 10–50 mol% steam at 800–1200°C. Reactivity of the Slurry Chars increased with the pyrolysis heating rate, but was lower than that of Original Chars. Kinetic parameters were established for a power-law rate model. Some measurements were initially done of gasification in CO₂.
A fluidized bed reactor, equipped with an atomization system, was constructed for gasification of bio-oil and slurry. The reactor contained either sand, or Ni-based catalyst. Experiments included gasification with pure steam and air. Effects of bed temperatures in the range 720–850°C, steam-to-carbon molar ratios of 2.0–7.5, and air ratios of 0–0.5 on gas composition and yields were tested. The carbon conversion of bio-oil to gas was found to be greater than that of slurry. The product gas composition was affected significantly by catalysis of the water-gas shift and the steam gasification. Greater yields of hydrogen and lesser yields of CO and hydrocarbons were found when catalyst was used. On a dry, inert-free basis, gases of up to 61% H₂ were obtained. The data were compared with a thermodynamic equilibrium model. The product gas yield was reasonably predictable by the model.
A mass and energy balance model of steam gasification in a dual-bed gasifier-combustor revealed that energy requirements are sensitive to the steam/carbon ratio and to the recovery of latent heat in the produced gas.
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Zolotovsky, Katia. "BioConstructs : methods for bio-inspired and bio-fabricated design." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77780.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Architecture, 2012.Cataloged from PDF version of thesis. Page 74 blank.
Includes bibliographical references (p. 72-73).
This work presents experimentation with design and fabrication methods, using biological systems either indirectly (as a source of inspiration and information for design) or directly (as a material production for fabrication). The focus is on "bioconstructs"- design methods and processes that are invented and developed under the influence of biological systems. Two projects are presented. The Polypterus project examines the unique design principles of the armor of an ancient fish and possible ways to use these principles in the design of synthetic protective and flexible applications (bio-inspired design). The project deals with the correlation between geometrical data (units' shape and rules of their composition on a surface) and functional data (anisotropic flexibility of the surface) to formulate a parametric design system. The Xylinus project focuses on the adaptation of material production by bacteria to a fabrication process (biofabrication). This fabrication method combines digital tools and technologies with material production by a living biological system. The long-term objective is to use cellulose-producing bacteria to develop an additive manufacturing technique for architecture and product design. Both projects suggest methods to utilize biological systems for innovative design and fabrication methods.
by Katia Zolotovsky.
S.M.
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Habib, MD Ahasan. "Designing Bio-Ink for Extrusion Based Bio-Printing Process." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/32045.
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Tissue regeneration using in-vitro scaffold becomes a vital mean to mimic the in-vivo counterpart due to the insufficiency of animal models to predict the applicability of drug and other physiological behavior. Three-dimensional (3D) bio-printing is an emerging technology to reproduce living tissue through controlled allocation of biomaterial and cell. Due to its bio-compatibility, natural hydrogels are commonly considered as the scaffold material in bio-printing process. However, repeatable scaffold structure with good printability and shape fidelity is a challenge with hydrogel material due to weak bonding in polymer chain. Additionally, there are intrinsic limitations for bio-printing of hydrogels due to limited cell proliferation and colonization while cells are immobilized within hydrogels and don’t spread, stretch and migrate to generate new tissue. The goal of this research is to develop a bio-ink suitable for extrusion-based bio-printing process to construct 3D scaffold. In this research, a novel hybrid hydrogel, is designed and systematic quantitative characterization are conducted to validate its printability, shape fidelity and cell viability. The outcomes are measured and quantified which demonstrate the favorable printability and shape fidelity of our proposed material. The research focuses on factors associated with pre-printing, printing and post-printing behavior of bio-ink and their biology. With the proposed hybrid hydrogel, 2 cm tall acellular 3D scaffold is fabricated with proper shape fidelity. Cell viability of the proposed material are tested with multiple cell lines i.e. BxPC3, prostate stem cancer cell, HEK 293, and Porc1 cell and about 90% viability after 15-day incubation have been achieved. The designed hybrid hydrogel demonstrate excellent behavior as bio-ink for bio-printing process which can reproduce scaffold with proper printability, shape fidelity and higher cell survivability. Additionally, the outlined characterization techniques proposed here open-up a novel avenue for quantifiable bio-ink assessment framework in lieu of their qualitative evaluation.
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Holmberg, Marc. "Life Time BoM : BoM-effektivisering ur ett Lean-perspektiv." Thesis, Umeå universitet, Institutionen för tillämpad fysik och elektronik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-165185.
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Beskrivning och analys av ett effektiviseringsprojekt på Sanminas fabrik i Örnsköldsvik. Projektet ska effektivisera BoM-hanteringsprocessen primärt genom tre förändringar. 1: Införa en BoM istället för flera. 2: Datorstöd istället för manuell hante-ring. 3: En konform hantering för alla projekt. Analysen av projektet grundas påLean-principer. Centrala begrepp som Lean och BoM beskrivs. En kvalitativ studiegenomförs med en fokusgrupp bestående av komponentingenjörer. Resultatet fråndenna ligger till grund för analysen. Ny metodik tolkas som effektivare än gammalmetodik på alla tre relevanta punkter. Ny metodik löser dock inte alla de bristersom finns i den gamla processen. Detta då de verktyg avsedda för interna processerinte har större inverkan på externa problem. Förändringarna tolkas som ett steg moten mer Lean BoM-hanteringsprocess. Fullständig analys kommer kunna genomförasnär ny metodik är implementerad. Diskussion kring tolkning av data och osäkerhet i analys av densamma. Detta då datan är kvalitativ.
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Hodgson, Ben Joseph. "Immobilisation of bio-molecules on magnetisable solid supports for applications in bio-catalysts and bio-sensors." Thesis, University of Central Lancashire, 2014. http://clok.uclan.ac.uk/10425/.
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A series of core and core-shell nanoparticles with superparamagnetic properties were synthesised and surface functionalised using three different amino-silanes by a chemical conjugation method. The functionalised nanoparticles were characterised and further modified by chemical conjugation with two different classes of bio-molecules; (i) enzymes and (ii) single stranded DNA primers. The resultant nanoparticles (nano-bio conjugates) were used for applications in (i) enzyme catalysis and (ii) bio-separation / bio-sensing. Magnetite and amorphous silica-coated core-shell nanoparticles were synthesised on both small (5 g) and large (20 g) scales and were characterised using transmission electron microscopy (TEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) surface area measurement and vibrating sample magnetometry (VSM). Silica-coated core-shell nanoparticles were functionalised by silanisation with three different aminosilanes [3-aminopropyl tri-ethoxysilane (APTS), 3-aminopropyl di-ethoxymethylsilane (APDS) and 3-aminopropyl mono-ethoxydimethylsilane (APMS)] and two different methods: water (classical method) or a Tri-phasic Reverse Emulsion (TPRE) using toluene and a surfactant (Triton X-100). It was observed that the materials prepared using the TPRE method produced higher surface amine density values on average. The first application involved bio-catalysis where lipases [Pseudomonas Fluorescens lipase (PFL) and Candida Rugosa lipase (CRL)] were chemically conjugated (covalently linked) via glutaraldehyde-modification onto the amino-functionalised nanoparticles for applications such as: (i) hydrolysis of p-nitrophenyl palmitate to produce palmitic acid and p-nitrophenol (model reaction), (ii) transesterification of ethyl butyrate with n-butanol to produce butyl butyrate and (iii) partial and selective hydrolysis of cis-3,5-diacetoxy-1-cyclopentene to produce pharmaceutically important and expensive chiral intermediate molecules. Various reaction parameters such as (a) water concentration in a bi-phasic solvent mixture and (b) temperature were investigated to determine the optimum conditions. All reactions were carried out using free lipases and the physically adsorbed lipases in order to compare the performance with chemically conjugated nano-biomaterials. It was observed from the bio-catalytic reaction (i) that the conversion values given by lipase-immobilised materials were comparable to those given by free lipases with the added advantage of being re-usable for further catalytic cycles. PFL-immobilised nanoparticles were shown to be more effective catalysts than CRL-immobilised materials. In the bio- catalytic reaction (ii), Lipase-immobilised materials were shown to exhibit reasonable conversion values (maximum 53%) along with easy separability by one-step magnetic separation from the reaction mixture and re-usability. Finally, in the bio-catalytic reaction (iii), lipase-immobilised materials were shown to give lower total conversion values compared to free enzymes, but a higher proportion of desired products [(1S,4R)-cis-4-acetoxy-2-cyclopenten-1-ol and (1R,4S)-cis-4-acetoxy-2-cyclopenten-1-ol]. PFL (both free and immobilised) materials were shown to give higher conversion and enantioselectivity towards the desired (1S,4R)-enantiomer (93-100% ee) than CRL materials (30-40% ee). The second application involved bio-separation and bio-sensing where 5ʹ-NH2-modified oligonucleotide sequences specific to either Listeria Monocytogenes (LM) or Escherichia Coli (EC) were immobilised onto the surface of glutaraldehyde modified nanoparticles to assess the specific capture and enhance the sensitivity of detection of pathogenic bacterial DNAs from food samples. Firstly, the oligonucleotide-grafted nanoparticles were used in a hybrid capture assay (model assay) at UCLan using specific single stranded DNA primers of our interest followed by the application in real food samples at Q-Bioanalytic GmbH, Germany. Capture of the complementary sequences was reasonably high (48-70% for LM-specific materials and 48-55% for EC-specific materials) when calculated as a molar ratio of conjugated oligonucleotides to complementary oligonucleotides captured. Specific capture was determined to be 33-52% for LM-specific oligonucleotide-grafted nano-materials and 59-60% for EC-specific oligonucleotide-grafted nano-materials. Dehybridisation of captured sequences was shown to be efficient for all oligonucleotide-grafted materials (72-97% for LM-specific materials and 86-87% for EC-specific materials), indicating that the materials were ready for real applications using food matrices at Q-Bioanalytic GmbH, Germany. Nucleic acid DNA was extracted from a real food sample inoculated with either LM or EC and the extracted DNA was used for specific capture using the oligonucleotide-grafted materials tested at UCLan. Dehybridised oligonucleotides were amplified and analysed using quantitative real-time PCR (qPCR). The results showed that using a one-step hybrid capture assay, LM-specific oligonucleotide-grafted materials were successful at detecting LM from an undiluted solution of LM only and from a 1:1 mixture of LM and EC. Using a two-step assay where the forward and reverse oligonucleotide-grafted materials were applied for capture separately, only EC-specific materials were successful for the detection of EC from an undiluted solution, and also from a 1:1 mixture of LM and EC.
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Ortloff, Peña Jessica. "Planta Bio Algás." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/100350.
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La conciencia ambiental y ecológica se ha instalado gradualmente en nuestra sociedad, y es por esto que cada día es mas común ver a la gente utilizando bolsas reutilizables, practicar el reciclaje en las casas, evitar duchas largas y optar por medios de transporte limpios como la bicicleta. No hay organismo que exija cumplir estas conductas, pero la conciencia de los chilenos se encauza en aportar con el medio ambiente, y esto tiene cada vez mas adeptos.
Las constantes discusiones sobre la generación y uso de energía se apoderan del discurso publico, y es que nadie queda ajeno a tener una opinión sobre el desarrollo de nuestro país y las consecuencias futuras de las acciones del presente. El ejemplo mas emblemático y reciente es la aprobación de Hidroaysén, que ha logrado convocar de modo transversal a todos los sectores sociales y políticos en una discusión generalizada sobre el desarrollo sustentable y la política energética de nuestro país.
Sin embargo, a falta de propuestas especificas que expresen una política concreta de desarrollo energético sustentable, cabe la interrogante sobre qué destino tienen aquellos estudios realizados por alumnos de diversos campos de estudio cada año y que demuestran la efectiva viabilidad de la utilización de energías no contaminantes. Las tecnologías existen, pero al parecer falta la disposición para ponerlas en marcha.
Por esto, la presenta investigación pretende dar una mirada multidisciplinaria a la problemática energética de nuestro país, enfocándose en el desarrollo de nuevas alternativas energéticas como son las Energías Renovables No Convencionales ERNC, de modo que la arquitectura se transforme en la disciplina materializadora y planeadora de una nueva posibilidad de producción de energía. También se pretende evaluar la efectiva viabilidad del proyecto, abarcando un estudio financiero que permita dar una mirada objetiva a las posibilidades de realización del proyecto.
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Didrichsons, Anja. "BMW Motorrad Spirit." Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149727.
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The aim of this thesis project was to create something, that has never been there before in motorcycle design. A new, deep collaboration between the future generation of riders and their bikes. It should create a whole new riding experience. And this experience should be inspirational and new to several fi elds of transportation design besides motorcycling. The process started with the research and inspiration fi nding. It continued with form exploration through sketching, ergonomic tests and photoshop sketches. The whole process was based on an interdisciplinary working method. Being in touch with modelers, engineers, generative designers, color and trim designers was an essential part of the project. The interdisciplinary work continued digitally, with many different types of software. Creating the 3D visualisation of the project required the use of Alias, Cinema 4D, Rhino, Grasshopper, Fuse, Speedform, Maya and VRED. Frequently reviews on the current project status and taking part in technical meetings, along with responsible designers at BMW, in combination with weekly reviews with the university, structured the time plan throughout the whole project. As well as fl ying to the university for check-ups and presentations. BMW Spirit provides a revolutionary experience for future motorcycle riders. Focusing on the interaction between the rider and the bike, it creates the opportunity to build a deep relationship. Since AI becomes more and more important in our daily lives developing ways of human-machine interactions will be crucial for our future. The concept is focused on the opportunities it could bring to combine an Artifi cial Intelligence with motorcycling. BMW Spirit creates a human-machine symbiosis and is controlled like an extension of the human body, with intuitive movements. The built in Artifi cial Intelligence is the rider’s companion and develops its own character and consciousness over time. It learns and grows together with the rider and adapted to the rider. Growing trust enables more possibilities to push the limits and enjoying the power of this unique riding experience.
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Železná, Hana. "Auto - bio - graf." Master's thesis, Akademie múzických umění v Praze. Filmová a televizní fakulta AMU. Knihovna, 2009. http://www.nusl.cz/ntk/nusl-79106.
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In my theoretical graduate work called AUTO-BIO-GRAF I sketch some impulses from which later becomes the autobiographical publication and I describe in which appearences we can see the autobiographical components in a movie.
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Lima, Donizeti José de. "Só sangue bom." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/85698.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Programa de Pós-Graduação em Educação.Made available in DSpace on 2012-10-20T21:49:47Z (GMT). No. of bitstreams: 1 195473.pdf: 559462 bytes, checksum: 1788ffb3a0f0afb2cf8abbecd14279d0 (MD5)
Análise de formas associativas instituídas, constituídas e mantidas por jovens em situação de empobrecimento. Esta análise parte do pressuposto que essas formas associativas são contextos privilegiados onde esses jovens vivenciam processos de resistência cultural e de construção de saberes, o que consideramos como expressões do protagonismo juvenil.
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Altman, Jean-Jacques. "Pancreas bio-artificiel." Paris 7, 1993. http://www.theses.fr/1993PA077114.
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Dans un pancreas bio-artificiel, une membrane a permeabilite selective permet sans immunosuppression la greffe de tissu insulinosecreteur qui peut assurer ses fonctions tout en etant protege du rejet. Nous avons successivement demontre avec notre technique de macroencapsulation en fibres creuses: 1. La possibilite de normalisation metabolique au long cours dans un modele de xenogreffe d'insulinome humain chez le rat diabetique streptozotocine. 2. La prevention des complications microangiopathiques. 3. La possibilite d'encapsulation de nombreux tissus endocrines. 4. L'efficacite du modele chez la souris nod diabetique auto-immune. 5. La faisabilite chez le porc diabetique. 6. Des experiences preliminaires ont pu etre realisees chez l'homme. De nombreuses ameliorations sont encore necessaires notamment au niveau de la biocompatibilite de la membrane pour que le pancreas bio-artificiel soit un traitement du diabete insulinodependant humain
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Martins-Mourão, Pedro Felgueiras dos Santos. "Bio vernacular design." Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2019. http://hdl.handle.net/10400.5/18184.
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Dissertação de Mestrado Integrado em Arquitetura, com a especialização em Interiores e Reabilitação do Edificado apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.Durante décadas, o Regionalismo Crítico mostrou aos arquitetos que a mediação entre a cultura universal e a cultura local pode ser o sucessor para a sociedade globalizada. No entanto, algo permanece em falta, a ligação com a pessoa ao local. Não tanto no sentido histórico, mas mais no sentido biológico. A natureza levou aproximadamente 3,8 bilhões de anos para descobrir, o que funciona e o que é apropriado para a sua sobrevivência, mas nós, como seres humanos, que valorizamos a nossa inteligência e tecnologia superiores, parecemos desconsiderar o poder de síntese da Mãe Natureza. A estratégia por detrás deste projeto é sobre a criação de um agregado urbano dentro de um dos climas mais inóspitos da Terra, o Sahara. Assim, como a natureza consegue prosperar em territórios de onde nenhuma vida parece emergir, o homem também consegue. Ao reinventar a habitação no deserto, inspirada pelos seus antigos antecessores e pela natureza, sociedades sustentáveis podem erguer-se e adaptar-se às circunstâncias em constante mudança. Um grupo de variantes e tipologias de casas maghrebinas são, por sua vez, criadas para responder a estes desafios, eventualmente tomando foco numa casa em particular para revelar as suas dinâmicas internas. A desertificação provou ser uma das forças mais letais que ameaçam ecossistemas estáveis devido a alterações climáticas, mas o desenvolvimento destas sociedades do deserto pode promover uma iniciativa de geo-engenharia para reverter este efeito e combater as alterações climáticas e ao mesmo tempo promovendo a cooperação entre comunidades interconectadas de diferentes reinos bioclimáticos.
ABSTRACT: For decades, Critical Regionalism has shown architects that mediation between universal culture and local culture can be the successor to a globalized society. However, something remains a miss, the connection to one’s location. Not so much in the historical sense, but more in the biological sense. Nature has taken approximately 3.8 billion years to figure out, what works and what is appropriate for its survival, yet we as humans, who value our superior intelligence and technology, seem to disregard Mother Nature’s power of synthesis. The strategy behind this project is about creating an urban aggregate within one of the harshest climates on earth, the Sahara. Thus proving that as nature can thrive in territories from where no life seems to emerge, so can man. By reinventing the desert dwelling, inspired by its ancient predecessors and nature, sustainable societies can rise and adapt to the ever-changing circumstances. A group of modular maghrebis home variants and typologies are, therefore created to respond to these chalenges, eventually taking focus on a specific dwelling to reveal its interior dynamics. Desertification has proven to be one of the deadliest forces threatening stable ecosystems due to climate change yet the development of these desert societies can promote a geoengineering initiative to reverse this effect as well as fight climate change entirely while promoting cooperation in interconnected communities from different bioclimatic realms.
N/A
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Russell, Scott Chandler. "Real time bio-warfare agent detection using bio-aerosol mass spectrometry /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
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Thesis (Ph. D.)--University of California, Davis, 2005.Degree granted in Chemistry. Dissertation completed in 2004; degree granted in 2005. Also available via the World Wide Web. (Restricted to UC campuses).