Relevant bibliographies by topics / BMP

Academic literature on the topic 'BMP'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "BMP":

1

Pascual, V., Y. J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J. D. Capra. "Analysis of somatic mutation in five B cell subsets of human tonsil." Journal of Experimental Medicine 180, no. 1 (July 1, 1994): 329–39. http://dx.doi.org/10.1084/jem.180.1.329.

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Using a series of phenotypic markers that include immunoglobulin (Ig)D, IgM, IgG, CD23, CD44, Bcl-2, CD38, CD10, CD77, and Ki67, human tonsillar B cells were separated into five fractions representing different stages of B cell differentiation that included sIgD+ (Bm1 and Bm2), germinal center (Bm3 and Bm4), and memory (Bm5) B cells. To establish whether the initiation of somatic mutation correlated with this phenotypic characterization, we performed polymerase chain reaction and subsequent sequence analysis of the Ig heavy chain variable region genes from each of the B cell subsets. We studied the genes from the smallest VH families (VH4, VH5, and VH6) in order to facilitate the mutational analysis. In agreement with previous reports, we found that the somatic mutation machinery is activated only after B cells reach the germinal center and become centroblasts (Bm3). Whereas 47 independently rearranged IgM transcripts from the Bm1 and Bm2 subsets were nearly germline encoded, 57 Bm3-, and Bm4-, and Bm5-derived IgM transcripts had accumulated an average of 5.7 point mutations within the VH gene segment. gamma transcripts corresponding to the same VH gene families were isolated from subsets Bm3, Bm4, and Bm5, and had accumulated an average of 9.5 somatic mutations. We conclude that the molecular events underlying the process of somatic mutation takes place during the transition from IgD+, CD23+ B cells (Bm2) to the IgD-, CD23-, germinal center centroblast (Bm3). Furthermore, the analysis of Ig variable region transcripts from the different subpopulations confirms that the pathway of B cell differentiation from virgin B cell throughout the germinal center up to the memory compartment can be traced with phenotypic markers. The availability of these subpopulations should permit the identification of the functional molecules relevant to each stage of B cell differentiation.
2

Pekkarinen, Tarmo, T. Sam Lindholm, Aulis Marttinen, Oili Hietala, and Pekka Jalovaara. "INFLUENCE OF ETHYLENE OXIDE STERILIZATION ON NEW BONE FORMATION INDUCED BY BOVINE BONE MORPHOGENETIC PROTEIN." Journal of Musculoskeletal Research 04, no. 04 (December 2000): 287–95. http://dx.doi.org/10.1142/s021895770000032x.

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Bone morphogenetic proteins (BMPs) have the capacity to induce and accelerate bone regeneration. Before experimental and clinical settings, BMP must be sterilized. Ethylene oxide (EO) gas sterilizations at different temperatures are commonly used but the effects of that on the osteoinductive capacity of BMP have been the subject of controversy. Here, we investigated the effects of three different EO sterilization methods on the osteoinductivity of partially purified native bovine BMP (bBMP). Gelatin capsules containing 3 mg of bBMP were sterilized as follows: (i) manually inside a dessicator with 12% EO spray (20°C, exposure time 2 h); (ii) with an EO gas sterilizer (Steri-Vac 4XL, temperature 29°C, exposure time 4 h 10 min, ethylene oxide concentration 860 mg/l); (iii) with an EO gas sterilizer (Steri-Vac 5XL, temperature 42°C, exposure time 3 h, ethylene oxide concentration 700 mg/l). The sterilization processes were monitored with samples of Bacillus subtilis (3M, Attest 1264). Osteoinductivity of bBMP was verified by bioassay. After 21 days of implantation of bBMP into the muscle pouches of mice, the animals were killed and new bone formation was measured radiographically and histologically. The EO sterilization techniques used did not significantly decrease the osteoinductive activity of BMP. It is concluded that commercial EO gas equipment sterilization is effective for sterilized BMP and does not decrease the osteoinductive capacity of bovine BMP.
3

Ping, Tsu-Ni, Shu-Ling Hsieh, Jyh-Jye Wang, Jin-Bor Chen, and Chih-Chung Wu. "Panax notoginseng Suppresses Bone Morphogenetic Protein-2 Expression in EA.hy926 Endothelial Cells by Inhibiting the Noncanonical NF-κB and Wnt/β-Catenin Signaling Pathways." Plants 11, no. 23 (November 28, 2022): 3265. http://dx.doi.org/10.3390/plants11233265.

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Panax notoginseng (PN) exerts cardiovascular-disease-protective effects, but the effect of PN on reducing vascular calcification (VC) is unknown. Under the VC process, however, endothelial bone morphogenetic protein-2 (BMP-2) signals connect endothelial and smooth muscle cells. To investigate the effects of PN water extract (PNWE) on BMP-2 expression, human EA.hy926 endothelial cells were pretreated with PNWE for 48 h, and BMP-2 expression was then induced using warfarin/β-glycerophosphate (W/BGP) for another 24 h. The expression of BMP-2, the degrees of oxidative stress and inflammation, and the activation of noncanonical NF-κB and Wnt/β-catenin signaling were analyzed. The results showed that the BMP-2 levels in EA.hy926 cells were reduced in the groups treated with 10, 50, or 100 μg/mL PNWE combined with W/BGP. PNWE combined with W/BGP significantly reduced thiobarbituric-acid-reactive substrate and reactive oxygen species levels as well as prostaglandin E2, IL-1β, IL-6, and TNF-α. PNWE (10, 50, and 100 μg/mL) reduced the p52 levels and p52/p100 protein ratio. Wnt and β-catenin protein expression was decreased in the groups treated with PNWE combined with W/BGP. These results showed that PNWE reduced BMP-2 expression in EA.hy926 cells by inhibiting the noncanonical NF-κB and Wnt/β-catenin signaling pathways.
4

Lim, Hyun-Chang, Daniel S. Thoma, So-Ra Yoon, Jae-Kook Cha, Jung-Seok Lee, and Ui-Won Jung. "Bone Regeneration Using N-Methyl-2-pyrrolidone as an Enhancer for Recombinant Human Bone Morphogenetic Protein-2 in a Rabbit Sinus Augmentation Model." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/4153073.

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The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits. In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP). The rabbits were sacrificed 2 weeks postoperatively. Histologic and histomorphometric analyses were performed. Bone formation in all groups was predominantly located close to the access window and the lateral walls. Newly formed bone within the total augmented area (NBTA) was greatest in BMP/NMP (1.94±0.69 mm2), followed by BMP (1.50±0.72 mm2) and BCP (1.28±0.52 mm2) (P>0.05). In the center of the augmentation (NBROI_C) and the area close to the sinus membrane (NBROI_M), BMP/NMP produced the largest area of NB (NBROI_C: 0.10±0.11 mm2; NBROI_M: 0.17±0.08 mm2); the corresponding NB values for BCP were 0.05±0.05 mm2 and 0.08±0.09 mm2, respectively (P>0.05 for all comparisons). The effect of NMP on bone regeneration was inconsistent between the specimens. Adding NMP as an adjunct to rhBMP-2-coated BCP produced inconsistent effects on bone regeneration, resulting in no significant benefit compared to controls.
5

Glaeser, Juliane D., Khosrowdad Salehi, Linda EA Kanim, Derek G. Ju, Jae Hyuk Yang, Phillip H. Behrens, Samuel A. Eberlein, et al. "Electrospun, synthetic bone void filler promotes human MSC function and BMP-2 mediated spinal fusion." Journal of Biomaterials Applications 35, no. 4-5 (July 5, 2020): 532–43. http://dx.doi.org/10.1177/0885328220937999.

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Introduction Synthetic bone grafts are often used to achieve a well-consolidated fusion mass in spinal fusion procedures. These bone grafts function as scaffolds, and ideally support cell function and facilitate protein binding. Objective The aim was to characterize an electrospun, synthetic bone void filler (Reb) for its bone morphogenetic protein (BMP)-2 release properties and support of human mesenchymal stem cell (hMSC) function in vitro, and its efficacy in promoting BMP-2-/bone marrow aspirate-(BMA)-mediated posterolateral spinal fusion (PLF) in vivo. Methods BMP-2 release kinetics from Reb versus standard absorbable collagen sponge (ACS) was determined. hMSC adhesion and proliferation on Reb was tested using cell counting, fluorescence microscopy and MTS. Cell osteogenic differentiation was quantified via cellular alkaline phosphatase (ALP) activity. For in vivo analysis, 18 Lewis rats were treated during PLF surgery with the following groups: (I) Reb + BMA, (II) Reb + BMA + BMP-2 and (III) BMA. A safe, minimally effective dose of BMP-2 was used. Fusion consolidation was followed for 3 months using radiography and micro-CT. After sacrifice, fusion rate and biomechanical stiffness was determined using manual palpation, biomechanical tests and histology. Results In vitro, BMP-2 release kinetics were similar between Reb versus ACS. MSC proliferation and differentiation were increased in the presence of Reb. At 3 months post-surgery, fusion rates were 29% (group I), 100% (group II), and 0% (group III). Biomechanical stiffness was higher in group II versus I. Micro-CT showed an increased bone volume and connectivity density in group II. Trabecular thickness was increased in group I versus II. H&E staining showed newly formed bone in group II only. Conclusions Reb possesses a high protein binding affinity and promotes hMSC function. Combination with BMA and minimal dose BMP-2 allowed for 100% bone fusion in vivo. This data suggests that a minimally effective dose of BMP-2 can be used when combined with Reb.
6

Lakdawala, Mohammed Farhan, Bhoomi Madhu, Lionel Faure, Mehul Vora, Richard W. Padgett, and Tina L. Gumienny. "Genetic interactions between the DBL-1/BMP-like pathway and dpy body size–associated genes in Caenorhabditis elegans." Molecular Biology of the Cell 30, no. 26 (December 15, 2019): 3151–60. http://dx.doi.org/10.1091/mbc.e19-09-0500.

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How BMP signaling and other body size regulators interact is not clear. We found interactions between Caenorhabditis elegans DBL-1/BMP and ECM, proteins that may modify or secrete DBL-1, and the SET domain protein BLMP-1. DBL-1 signaling may control downstream targets, some through BLMP-1, that affect size either directly or by feeding back on DBL-1 signaling.
7

Cheng, Gang, Hong Chen, Kai Wang, Jinxing Gao, Xiao Li, Hui Dong, and Shuyan Liu. "Biphasic Calcium Phosphate/Chitosan/Polyacrylonitrile/Polylactic Acid-Glycolic Acid (PLGA) Nanocomposite Stent for Repair and Osteogenesis of Oral Alveolar Bone Defect." Science of Advanced Materials 13, no. 7 (July 1, 2021): 1324–34. http://dx.doi.org/10.1166/sam.2021.4039.

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ABSTRACTThe ability of sol-gel micro-nano biphasic calcium stent to repair oral alveolar bone defects was investigated in this study, and its osteogenesis performance was also analyzed. Biphasic calcium phosphate (BCP) was synthesized by wet method, which was combined with chitosan (CS), polyacrylonitrile (PAN), and polylactic acid-glycolic acid (PLGA). Then, the BCP/CS/PAN/PLGA nanocomposite stent was prepared by vacuum freeze-drying technology. The micro-nano composite stent was combined with the bone morphogenetic protein-2 (BMP-2) gene, so as to obtain the sol-gel micro-nano biphasic calcium BMP-2/BCP/CS/PAN/PLGA composite stent. Besides, the composite stent should be measured in terms of compressive strength, porosity, structure, and morphological features. The healthy female rhesus monkeys were taken as the research animals, and the iliac bone marrow was extracted by puncture. The mesenchymal stem cells (MSCs) were obtained by density gradient centrifugation, and their osteogenic differentiation ability was observed. The MSCs were cultured in vitro with BMP-2/BCP/CS/PAN/PLGA composite stent, methylthiazolyldiphenyl-tetrazolium bromide (MTT) was applied to detect cell adhesion and proliferation, and the alkaline phosphatase (ALP) activity was employed to analyze its osteogenic properties on stent materials. In addition, the expression of BMP-2 was detected by Western blot. The alveolar bone defect models were established and divided into group A (MSCs + BMP-2/BCP/CS/PAN/PLGA), group B (BMP-2/BCP/CS/PAN/PLGA), group C (BCP/CS/PAN/PLG), and group D (control group, reposition of gingival flap and suture) according to different implant materials. The changes of bone defect area in different groups were detected by gross examinations and X-ray, so that the new bone density was analyzed. The results showed that the BCP/CS/PAN/PLGA composite stent exhibited a porous structure combining multiple pores/small pores, with an average pore diameter (PD) of 400–500 µm, maximum compressive strength of 6.02 Mpa, and porosity of 86.82%. MSCs differentiated into osteoblasts under osteogenic induction conditioned medium, and the optical density (OD) of CS + MSCs/BMP-2/BCP/CS/PAN/PLGA cells was greater in contrast to that of MSCs/BMP-2/BCP/CS/PAN/PLGA cells on the 1st and 7th day of culture, showing a statistical difference (P < 0.05). The gross examination and X-ray of bone defect area in group A showed that its bone structure and density were very close to those of normal bone (all materials were absorbed, and newly formed bone cells were active); the CT value of alveolar bone in groups A, B, C, and D was 1,092.45± 15.87 g/cm3, 932.26± 16.75 g/cm3, 859.51 ±17.86 g/cm3, and 787.96± 16.54 g/cm3, respectively. There was no marked difference in CT values between group A and normal alveolar bone (P > 0.05), while the CT value of alveolar bone in group A was higher obviously than the value of groups C and D (P < 0.05). It indicated that the composite stent based on sol–gel micro-nano biphasic calcium BMP-2/BCP/CS/PAN/PLGA could promote the repair of oral alveolar bone defect and its osteogenesis, thereby providing a reference for the oral clinical treatment of periodontal bone defects.
8

Ammar, Hany R., Subbarayan Sivasankaran, and Abdulaziz S. Alaboodi. "Investigation of the Microstructure and Compressibility of Biodegradable Fe-Mn-Cu/W/Co Nanostructured Alloy Powders Synthesized by Mechanical Alloying." Materials 14, no. 11 (June 4, 2021): 3088. http://dx.doi.org/10.3390/ma14113088.

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In this research work, the nanostructured Fe-Mn (BM0), Fe-Mn-Cu (BM1), Fe-Mn-W (BM2), and Fe-Mn-Co (BM3) biodegradable alloys were successfully synthesized using mechanical alloying. The microstructure of the synthesized alloys was examined using XRD, SEM equipped with EDS, and HRTEM techniques. The results obtained based on these techniques confirmed the development of nanostructured BM0, BM1, BM2, and BM3 alloys and homogenous solid solutions with an even elemental dispersion. The compressibility of the synthesized alloys was investigated experimentally and empirically in the as-milled conditions and after applying a stress relief treatment (150 °C for 1 h). The load applied for compaction experiments ranged from 25–1100 MPa with a rate of 1 mm/min. According to the experimentation performed in the current study, the relative density of the as-milled BM0, BM1, BM2, and BM3 alloys was 72.90% and 71.64%, 72.32%, and 72.03%, respectively. After applying the stress relief treatment, the density was observed to increase to 75.23%, 77.10%, 72.65%, and 72.86% for BM0-S, BM1-S, BM2-S and BM3-S samples, respectively. A number of compaction models were tested to identify the optimum models for predicting the compressibility behavior of nanostructured Fe-Mn, Fe-Mn-Cu, Fe-Mn-W, and Fe-Mn-Co alloys in the as-milled and stress-relieved conditions.
9

Song, Sang-Heon, Young-Pil Yun, Hak-Jun Kim, Kyeongsoon Park, Sung Eun Kim, and Hae-Ryong Song. "Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl Cellulose/BioC/Bone Morphogenic Protein-2 Hybrid Materials." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/230152.

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The objective of this study was to assess whether carboxymethyl cellulose- (CMC-) based hydrogel containing BioC (biphasic calcium phosphate (BCP); tricalcium phosphate (TCP) : hydroxyapatite (Hap) = 70 : 30) and bone morphogenic protein-2 (BMP-2) led to greater bone formation than CMC-based hydrogel containing BioC without BMP-2. In order to demonstrate bone formation at 4 and 8 weeks, plain radiographs, microcomputed tomography (micro-CT) evaluation, and histological studies were performed after implantation of all hybrid materials on an 8 mm defect of the right tibia in rats. The plain radiographs and micro-CT analyses revealed that CMC/BioC/BMP-2 (0.5 mg) led to much greater mineralization at 4 and 8 weeks than did CMC/BioC or CMC/Bio/BMP-2 (0.1 mg). Likewise, bone formation and bone remodeling studies revealed that CMC/BioC/BMP-2 (0.5 mg) led to a significantly greater amount of bone formation and bone remodeling at 4 and 8 weeks than did CMC/BioC or CMC/BioC/BMP-2 (0.1 mg). Histological studies revealed that mineralized bone tissue was present around the whole circumference of the defect site with CMC/BioC/BMP-2 (0.5 mg) but not with CMC/BioC or CMC/BioC/BMP-2 (0.1 mg) at 4 and 8 weeks. These results suggest that CMC/BioC/BMP-2 hybrid materials induced greater bone formation than CMC/BioC hybrid materials. Thus, CMC/BioC/BMP-2 hybrid materials may be used as an injectable substrate to regenerate bone defects.
10

Mehryar, Esmaeil, Weimin Ding, Abbas Hemmat, Muhammad Hassan, Zahir Talha, Jalal Kafashan, and Hongying Huang. "Modeling and Multiresponse Optimization for Anaerobic Codigestion of Oil Refinery Wastewater and Chicken Manure by Using Artificial Neural Network and the Taguchi Method." BioMed Research International 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/2036737.

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To study the optimum process conditions for pretreatments and anaerobic codigestion of oil refinery wastewater (ORWW) with chicken manure, L9 (34) Taguchi’s orthogonal array was applied. The biogas production (BGP), biomethane content (BMP), and chemical oxygen demand solubilization (CODS) in stabilization rate were evaluated as the process outputs. The optimum conditions were obtained by using Design Expert software (Version 7.0.0). The results indicated that the optimum conditions could be achieved with 44% ORWW, 36°C temperature, 30 min sonication, and 6% TS in the digester. The optimum BGP, BMP, and CODS removal rates by using the optimum conditions were 294.76 mL/gVS, 151.95 mL/gVS, and 70.22%, respectively, as concluded by the experimental results. In addition, the artificial neural network (ANN) technique was implemented to develop an ANN model for predicting BGP yield and BMP content. The Levenberg-Marquardt algorithm was utilized to train ANN, and the architecture of 9-19-2 for the ANN model was obtained.
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Journal articles Dissertations / Theses Books

Dissertations / Theses on the topic "BMP":

1

Wardle, Fiona Claire. "Regulation of the BMP signalling pathway by BMP-1 related metalloproteases." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287477.

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2

Aramaki, Toshihiro. "Jiraiya Attenuates BMP Signaling by Interfering with Type-II BMP Receptors in Neuroectodermal Patterning." Kyoto University, 2011. http://hdl.handle.net/2433/142060.

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3

Zanchettin, Gianpietro. "BMP axis in cancer cachexia." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425867.

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BACKGROUND Cancer cachexia is a devastating metabolic syndrome characterized by systemic inflammation and massive muscle and adipose tissue wasting. Although cancer cachexia is responsible for about 25% of cancer deaths, no effective therapies are available, and the underlying mechanisms have not been fully elucidated. Its occurrence complicates patients’ management, reduces tolerance to treatments and negatively affects patient quality of life. Muscle wasting, mainly due to increased protein breakdown rates, is one of the most prominent features of cachexia. Blocking muscle loss in cachexia mouse models dramatically prolongs survival even of animals in which tumor growth is not inhibited. Recent observations showed that bone morphogenetic protein (BMP) signaling, acting through Smad1, Smad5 and Smad8 (Smad1/5/8), is a master regulator of muscle homeostasis. BMP-Smad1/5/8 axis negatively regulates a novel ubiquitin ligase (MUSA1) required for muscle loss induced by denervation. MATERIALS AND METHODS First aim of the present work was to test if alterations of the BMP signaling pathway occur in cancer-induced muscle wasting in patients. For this purpose we checked the state of activation of the BMP pathway in muscle of cachectic vs non–cachectic patients affected by colon, pancreatic and esophagus cancer and in control subjects. We checked by Western Blot the phosphorylation levels of Smad1/5/8 and of Smad3 and by quantitative Real-Time PCR (qRT-PCR) the expression levels of different atrophy-related genes The second aim was to evaluate the degree of muscle atrophy and distribution of muscle fibers in patients and control subjects using morphometric and immunohistochemical analyses. We also performed analysis on distribution of NCAM positive muscle fibers to assess the effect of denervation on muscle tropism. RESULTS From December 2014 we collected 95 rectus abdominis muscle biopsies of cancer patients and 11 from control subjects. In line with the results we obtained in C26 mice model (a well-established cancer cachexia experimental model) Smad1/5/8 phosphorylation, readout of the state of activation of the BMP pathway, was nearly completely abrogated in the muscles of cancer cachectic patients compared to cancer non-cachectic ones. Interestingly, the level of phosphorylation of Smad3 was not significantly affected suggesting specific effects of cancer growth on BMP pathway. The expression levels of different atrophy-related genes including MUSA1 were induced in the cachectic muscles. Interestingly, several BMP related genes are also changing the expression during cancer growth. We also found a correlation between suppression of BMP pathway, expression of atrophy related genes and Noggin, known to block BMP pathway. Morphometric analysis shown that patients with cancer cachexia have smaller myofiber diameter (in particular fast type fibers) in comparison to age-matched controls. In skeletal muscle from cancer patients (either cachectic or non-cachectic) we detected a prevalence of flat shaped, angulated and severely atrophic myofibers (i.e. morphological features of denervated myofibers), big fiber-type grouping (i.e. typical hallmark of denervation/reinnervation events) and numerous NCAM positive myofibers (i.e. specific marker of denervation). CONCLUSIONS These findings are consistent with the hypothesis that BMP inhibition is permissive to cachexia onset. Since the reactivation of the BMP-dependent signaling and MUSA1 suppression was sufficient to prevent tumor-induced muscle atrophy in our C26 mouse model (data not shown), the present data suggest that the BMP axis can be an effective target for therapeutic approaches to counteract cachexia also in cancer patients. The results of morphometric and immunohistochemical studies collected till now may suggest that denervation contributes to myofiber atrophy in cancer cachexia.
BACKGROUND Cancer cachexia is a devastating metabolic syndrome characterized by systemic inflammation and massive muscle and adipose tissue wasting. Although cancer cachexia is responsible for about 25% of cancer deaths, no effective therapies are available, and the underlying mechanisms have not been fully elucidated. Its occurrence complicates patients’ management, reduces tolerance to treatments and negatively affects patient quality of life. Muscle wasting, mainly due to increased protein breakdown rates, is one of the most prominent features of cachexia. Blocking muscle loss in cachexia mouse models dramatically prolongs survival even of animals in which tumor growth is not inhibited. Recent observations showed that bone morphogenetic protein (BMP) signaling, acting through Smad1, Smad5 and Smad8 (Smad1/5/8), is a master regulator of muscle homeostasis. BMP-Smad1/5/8 axis negatively regulates a novel ubiquitin ligase (MUSA1) required for muscle loss induced by denervation. MATERIALS AND METHODS First aim of the present work was to test if alterations of the BMP signaling pathway occur in cancer-induced muscle wasting in patients. For this purpose we checked the state of activation of the BMP pathway in muscle of cachectic vs non–cachectic patients affected by colon, pancreatic and esophagus cancer and in control subjects. We checked by Western Blot the phosphorylation levels of Smad1/5/8 and of Smad3 and by quantitative Real-Time PCR (qRT-PCR) the expression levels of different atrophy-related genes The second aim was to evaluate the degree of muscle atrophy and distribution of muscle fibers in patients and control subjects using morphometric and immunohistochemical analyses. We also performed analysis on distribution of NCAM positive muscle fibers to assess the effect of denervation on muscle tropism. RESULTS From December 2014 we collected 95 rectus abdominis muscle biopsies of cancer patients and 11 from control subjects. In line with the results we obtained in C26 mice model (a well-established cancer cachexia experimental model) Smad1/5/8 phosphorylation, readout of the state of activation of the BMP pathway, was nearly completely abrogated in the muscles of cancer cachectic patients compared to cancer non-cachectic ones. Interestingly, the level of phosphorylation of Smad3 was not significantly affected suggesting specific effects of cancer growth on BMP pathway. The expression levels of different atrophy-related genes including MUSA1 were induced in the cachectic muscles. Interestingly, several BMP related genes are also changing the expression during cancer growth. We also found a correlation between suppression of BMP pathway, expression of atrophy related genes and Noggin, known to block BMP pathway. Morphometric analysis shown that patients with cancer cachexia have smaller myofiber diameter (in particular fast type fibers) in comparison to age-matched controls. In skeletal muscle from cancer patients (either cachectic or non-cachectic) we detected a prevalence of flat shaped, angulated and severely atrophic myofibers (i.e. morphological features of denervated myofibers), big fiber-type grouping (i.e. typical hallmark of denervation/reinnervation events) and numerous NCAM positive myofibers (i.e. specific marker of denervation). CONCLUSIONS These findings are consistent with the hypothesis that BMP inhibition is permissive to cachexia onset. Since the reactivation of the BMP-dependent signaling and MUSA1 suppression was sufficient to prevent tumor-induced muscle atrophy in our C26 mouse model (data not shown), the present data suggest that the BMP axis can be an effective target for therapeutic approaches to counteract cachexia also in cancer patients. The results of morphometric and immunohistochemical studies collected till now may suggest that denervation contributes to myofiber atrophy in cancer cachexia.
4

Lauzon, Marc-Antoine. "Modélisation d'un système de libération d'un peptide dérivé de la BMP-9 et étude mécanistique comparative entre la BMP-9 et la BMP-2." Mémoire, Université de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/103.

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Le vieillissement croissant de la population canadienne aura une incidence, dans les années à venir, sur les risques de fractures ostéoporotiques et autres pathologies de l'os. Parmi ces risques, les fractures avec pertes osseuses présentent des défis considérables et causent un lourd fardeau économique. La société Ostéoporose Canada estime que plus de 30 milliards de dollars seront dépensés pour le traitement de l’ostéoporose et de leurs fractures associées d’ici 2018. La méthode de comblement des pertes osseuses standard actuelle, soit l'autogreffe, est limitée et présente des risques pour le patient. À titre d'alternative, deux stratégies ont été jusqu'à maintenant étudiées: les systèmes de libération de facteurs de croissance (« growth factor delivery systems », GFDS) et le développement de matériaux biomimétiques. Ces deux stratégies ont comme point commun l'utilisation de facteurs de croissance ostéogéniques comme les protéines morphogénétiques osseuses (BMPs), telles la BMP-2 (référence commerciale) et la BMP-9. Malgré leur effet important, les BMPs restent couteuses à produire. Le laboratoire de N. Faucheux a développé un peptide (pBMP-9) dérivé de la BMP-9 qui possède un effet ostéogénique démontré, mais dont les mécanismes d’action et le comportement en système de libération restent à être étudiés. Les objectifs de ce projet de recherche ont donc porté sur l’étude du comportement de cellules osseuses préostéoblastes murins (MC3T3-E1) face à ces facteurs de croissance ainsi que sur le suivi et la modélisation des cinétiques de libération du pBMP-9 à partir d’une matrice de collagène, utilisée actuellement en clinique. Le mémoire possède ainsi trois volets. Le premier volet de ces travaux a consisté à faire une revue de la littérature sur le processus de régénération osseuse endochondrale afin de bien comprendre le rôle joué par les facteurs de croissance et cerner les défis de conception d’un GFDS utilisé en régénération osseuse. Les nouvelles approches de GFDS ont été revues en détail ainsi que les principaux modèles mathématiques développés et appliqués aux molécules thérapeutiques. Cette revue de la littérature a été publiée dans Journal of Controlled Release. Le second volet de ces travaux s’est penché sur l’étude et la modélisation mathématique des cinétiques de libération du pBMP-9 à partir d’hydrogels de collagène. Les résultats expérimentaux ont mené à la rédaction d’un article qui vient d’être accepté dans la revue Journal of Controlled Release. Cette étude consistait à évaluer les mécanismes de transfert de masse impliqués dans la libération pour différentes concentrations de pBMP-9 à partir d'hydrogels de collagène. Les cinétiques de libération ont été modélisées et ont montré la présence d'interactions importantes entre le pBMP-9 et les fibres de collagène. Le troisième volet a consisté à déterminer l'effet dose de la BMP-9 et de la BMP-2 sur la capacité des MC3T3-E1 à se différencier en présence ou en absence de sérum de veau foetal (« foetal bovine serum », FBS). Ces travaux ont conduit à la rédaction d’un article qui vient d’être accepté dans la revue Tissue Engineering Part A. La BMP-9 étant jusqu'alors mal comprise, l'étude s'est penchée sur cette protéine tout en ayant comme objectif de transposer les connaissances au pBMP-9. Les résultats ont démontré que les mécanismes d'action de la BMP-9 étaient très différents de ceux de la BMP-2 en présence de FBS. Les résultats ont également permis d'établir que, à l'instar de la BMP-2, la présence de FBS potentialise fortement l'effet ostéogénique de la BMP-9. Cet effet a d’ailleurs pu être récréé par l’IGF-2. Les conclusions de ce travail favoriseront le développement de systèmes de libération ostéogéniques plus efficaces.
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Budde, Christian. "Immunhistochemische Beurteilung von BMP-2 und BMP-4 in der humanen ungestörten und verzögerten Frakturheilung." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96584630X.

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Hillger, Frank. "Rekombinante Herstellung und biophysikalische Charakterisierung von proBMP-2, BMP-2 und dem BMP-2-Propeptid." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975601210.

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Kirchhoff, Christina [Verfasser], and Hagen [Akademischer Betreuer] Schmal. "Die Lokalisation von BMP-2, BMP-7 und deren Rezeptoren im Kniegelenk bei umschriebenem Knorpelschaden." Freiburg : Universität, 2014. http://d-nb.info/1122742517/34.

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Tanaka, Mari. "Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury." Kyoto University, 2009. http://hdl.handle.net/2433/124309.

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Carvalho, Sara Catarina da Silva. "O papel das BMPs na regeneração óssea." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5139.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária
O tecido ósseo quando lesado possui capacidade de regeneração. No entanto, na presença de certas patologias ou lesões, esta capacidade poderá ser comprometida. Neste contexto, a fração de uma proteína foi isolada da matriz óssea desmineralizada, denominando-se Bone Morphogenetic Proteins (BMPs) ou Proteínas Morfogenéticas do Osso; descobertas pelo Dr. Marshall Urist em 1965. Estas proteínas parecem constituir uma boa alternativa no contorno deste problema, uma vez que possuem capacidade de formar cartilagem e novo osso (inclusive osso heterotópico). O seu uso clínico foi aprovado pela Food and Drug Administration (FDA), respetivamente a BMP 7 e BMP 2. Devido ao seu potencial osteoindutivo e osteocondutivo, vários estudos in vitro e in vivo têm decorrido desde a sua descoberta. Sendo que estes fatores tornaram-se de grande interesse em várias áreas como a Ortopedia na Medicina e Cirurgia Oral na Medicina Dentária. Esta revisão bibliográfica tem como intuito o esclarecimento a partir da informação disponível acerca destas proteínas, nomeadamente, a sua constituição, mecanismos de ação, fatores condicionantes e potenciadores da sua ação, aplicações clínicas (inclusive na área da Medicina Dentária) e limitações no seu uso como fator regenerativo. Bone tissue when injured has the ability of regeneration. However, in the presence of certain pathologies or lesions, this ability can be compromised. In this context, a fraction of a protein was isolated from the demineralized bone matrix, called Bone Morphogenetic Proteins (BMPs); discovered by Dr. Marshall Urist in 1965. These proteins appear to be a good alternative to the overcome this problem, as they possess the ability to form new cartilage and bone, even heterotopic bone. Their clinical use was approved by Food and Drug Administration (FDA), respectively BMP 7 and BMP 2. Due to their osteoinductive and osteoconductive potential, several in vitro and in vivo studies have occurred since their discovery. Therefore these factors have become of great interest in various fields such as Orthopedics in Medicine and Oral Surgery in Dentistry. This literature review has the aim to clarify the available information about these proteins, namely, their constitution, mechanisms of action, conditioning factors and enhancers of their action, clinical applications (including in the field of Dentistry) and limitations of their use as a regenerative factor.
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Krätzig, Matthias [Verfasser]. "Untersuchungen zur Renaturierung und Aufreinigung von BMP-2 und BMP-4 aus Escherichia coli / Matthias Krätzig." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1097220141/34.

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Books on the topic "BMP":

1

Kominek, Ryszard T. BMP-2. Lublin: OW Kagero, 2005.

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Suvorov, Sergej. BMP (BWP)-2. Warszawa: Wydawnictwo Militaria, 2009.

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Bianchi, Lautaro, and Guillermo Raúl Kliczkowski. BMP: Bianchi Monserrat Peña Arquitectos. Buenos Aires: Kliczkowski, 2007.

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National Council of Building Material Producers., ed. BMP exporting division: Country factfile. London: National Council of Building Material Producers, 1993.

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Zaloga, Steve. El vehículo de infantería BMP. Barcelona: RBA Coleccionables, 1999.

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Lewis, Thera Cathy. Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El. [New York, N.Y.?]: [publisher not identified], 2013.

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Michael, Quinn, Washington State University Extension, and United States. Dept. of Agriculture., eds. Jointed goatgrass best management practice (BMP): Intermountain Region. [Pullman, WA: Washington State University Extension, 2007.

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1939-, Field Richard, ed. BMP technology in urban watersheds: Current and future directions. Reston, Va: American Society of Civil Engineers, 2006.

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California. Dept. of Transportation., ed. San Francisco-Oakland Bay Bridge treatment BMP feasibility study. [Oakland, Calif.]: The Dept., 2000.

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Miano, John. Compressed image file formats: JPEG, PNG, GIF, XBM, BMP. Reading, Ma: Addison Wesley Longman, 1999.

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Book chapters on the topic "BMP":

1

Nolan, Kristof, and Thomas B. Thompson. "BMP and BMP Regulation: Structure and Function." In Bone Morphogenetic Proteins: Systems Biology Regulators, 73–111. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47507-3_4.

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Sonobe, Junya, and Kazuhisa Bessho. "6. Bone Morphogenetic Proteins ~BMP-2 and BMP-7." In Translating Biomaterials for Bone Graft, 93–106. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2016. http://dx.doi.org/10.1201/9781315363530-7.

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Estrada, Kristine D., and Karen M. Lyons. "BMP Signaling in Skeletogenesis." In Bone and Development, 125–36. London: Springer London, 2010. http://dx.doi.org/10.1007/978-1-84882-822-3_8.

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Parkin, Alan. "1-bit .BMP File." In Digital Imaging Primer, 435–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-540-85619-1_26.

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Parkin, Alan. "4-bit .BMP File." In Digital Imaging Primer, 497–503. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-540-85619-1_33.

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Dutta, Joyita, Chris Bowens, and Anja Nohe. "Dynamics of BMP Receptor Signaling." In Encyclopedia of Biophysics, 1–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-35943-9_793-1.

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Dutta, Joyita, Chris Bowens, and Anja Nohe. "Dynamics of BMP Receptor Signaling." In Encyclopedia of Biophysics, 537–41. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-16712-6_793.

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Haidar, Ziyad S., and Murugan Ramalingam. "BMP-based Bone Tissue Engineering." In Integrated Biomaterials for Biomedical Technology, 273–92. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118482513.ch7.

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Herr, G., W. Küsswetter, F. Thielemann, U. Schmid, and U. Holz. "Kombination von BMP mit verschiedenen keramischenTrägermaterialien." In Hefte zur Zeitschrift „Der Unfallchirurg“, 168–75. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-00855-3_25.

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Meinel, Christoph, and Maxim Asjoma. "Pixelcodes – BMP, JPEG, PNG und Co." In Die neue digitale Welt verstehen, 55–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-63701-2_9.

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Conference papers on the topic "BMP":

1

Mao, Fubing, Yi-Chung Chen, Wei Zhang, and Hai Li. "BMP." In FPGA'14: The 2014 ACM/SIGDA International Symposium on Field-Programmable Gate Arrays. New York, NY, USA: ACM, 2014. http://dx.doi.org/10.1145/2554688.2554755.

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Bergeron, Frédéric, Kevin Bouchard, Sylvain Giroux, and Sebastien Gaboury. "BMP." In GoodTechs '19: EAI International Conference on Smart Objects and Technologies for Social Good. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3342428.3342696.

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"DAFTAR ISI - BMP." In SEMINAR NASIONAL FISIKA 2016 UNJ. PRODI Pendidikan Fisika dan Fisika UNJ, 2016. http://dx.doi.org/10.21009/0305020300.

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Struck, Scott, Robert Traver, Wayne C. Huber, Fu-hsiung Lai, LaMarr Clannon, Matt Stouder, Angela Brown, et al. "BMP Modeling Techniques." In Water Resources and Environment History Sessions at Environmental and Water Reources Institute Annual Meeting 2004. Reston, VA: American Society of Civil Engineers, 2006. http://dx.doi.org/10.1061/9780784408728.009.

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Clary, Jane, Marc Leisenring, Aaron Poresky, Andrew Earles, and Jonathan Jones. "BMP Performance Analysis Results for the International Stormwater BMP Database." In World Environmental and Water Resources Congress 2011. Reston, VA: American Society of Civil Engineers, 2011. http://dx.doi.org/10.1061/41173(414)47.

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Barrett, Michael E. "BMP Performance Comparisons: Examples from the International Stormwater BMP Database." In World Water and Environmental Resources Congress 2005. Reston, VA: American Society of Civil Engineers, 2005. http://dx.doi.org/10.1061/40792(173)163.

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Leisenring, Marc, Michael Barrett, Aaron Poresky, Eric Strecker, Charles Rowney, Christine Pomeroy, and Larry Roesner. "BMP Performance Algorithms for the BMP Selection/Receiving Water Protection Toolbox." In World Environmental And Water Resources Congress 2012. Reston, VA: American Society of Civil Engineers, 2012. http://dx.doi.org/10.1061/9780784412312.355.

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Horst, Michael, Robert Traver, and Erika Tokarz. "BMP Pollutant Removal Efficiency." In World Environmental and Water Resources Congress 2008. Reston, VA: American Society of Civil Engineers, 2008. http://dx.doi.org/10.1061/40976(316)429.

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Heasom, William, and Robert G. Traver. "Modeling a Bioinfiltration BMP." In World Water and Environmental Resources Congress 2003. Reston, VA: American Society of Civil Engineers, 2003. http://dx.doi.org/10.1061/40685(2003)334.

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Bonigut, Tom, and Scott Taylor. "Identifying Regional BMP Retrofit Opportunities." In World Water and Environmental Resources Congress 2005. Reston, VA: American Society of Civil Engineers, 2005. http://dx.doi.org/10.1061/40792(173)189.

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Reports on the topic "BMP":

1

Fernando, R., and S. Stuart. BGP Monitoring Protocol (BMP). Edited by J. Scudder. RFC Editor, June 2016. http://dx.doi.org/10.17487/rfc7854.

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Evens, T., S. Bayraktar, M. Bhardwaj, and P. Lucente. Support for Local RIB in the BGP Monitoring Protocol (BMP). RFC Editor, February 2022. http://dx.doi.org/10.17487/rfc9069.

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Evens, T., S. Bayraktar, P. Lucente, P. Mi, and S. Zhuang. Support for Adj-RIB-Out in the BGP Monitoring Protocol (BMP). RFC Editor, November 2019. http://dx.doi.org/10.17487/rfc8671.

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Howard, Heidi, Chad Helmle, Raina Dwivedi, and Daniel Gambill. Stormwater Management and Optimization Toolbox. Engineer Research and Development Center (U.S.), January 2021. http://dx.doi.org/10.21079/11681/39480.

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As stormwater regulations for hydrologic and water quality control become increasingly stringent, Department of Defense (DoD) facilities are faced with the daunting task of complying with multiple laws and regulations. This often requires facilities to plan, design, and implement structural best management practices (BMPs) to capture, filter, and/or infiltrate runoff—requirements that can be complicated, contradictory, and difficult to plan. This project demonstrated the Stormwater Management Optimization Toolbox (SMOT), a spreadsheet-based tool that effectively analyzes and plans for compliance to the Energy Independence and Security Act (EISA) of 2007 pre-hydrologic conditions through BMP implementation, resulting in potential cost savings by reducing BMP sizes while simultaneously achieving compliance with multiple objectives. SMOT identifies the most cost-effective modeling method based on an installation’s local conditions (soils, rainfall patterns, drainage network, and regulatory requirements). The work first demonstrated that the Model Selection Tool (MST) recommendation accurately results in the minimum BMP cost for 45 facilities of widely varying climatic and regional conditions, and then demonstrated SMOT at two facilities.
5

Lueck, K. J. ,. Westinghouse Hanford. Miscellaneous streams best management practices (BMP) report. Office of Scientific and Technical Information (OSTI), July 1996. http://dx.doi.org/10.2172/664388.

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Willoughby, Brian. BMP Systems Engineering Model Using Concurrent Engineering Methods. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ada397399.

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Yager, Robert J. Reading, Writing, and Modifying BMP Files Using C++. Fort Belvoir, VA: Defense Technical Information Center, August 2013. http://dx.doi.org/10.21236/ada591616.

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Smith, Shannon. Maintenance Connection (MC) MC Tablet Hybrid Software Training for BMP Inspections. Office of Scientific and Technical Information (OSTI), June 2014. http://dx.doi.org/10.2172/1136105.

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SuPrise, Anne Marie T. BMP Report of Survey Conducted at General Tool Company, Cincinnati, OH. Fort Belvoir, VA: Defense Technical Information Center, October 2002. http://dx.doi.org/10.21236/ada411802.

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Wiest, M. C. Jr. Best Management Practices (BMP) plan for potable water discharges Y-12 Plant. Office of Scientific and Technical Information (OSTI), July 1995. http://dx.doi.org/10.2172/109522.

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