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Journal articles on the topic 'BOC26P'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Xiaojuan, Li, Li Xiaojuan, Li Xiaojuan, Lin Lina, Cai Shaohui, and Xu Jun. "Studies On the Anti-Proliferative Effects and Molecular Mechanism of a Novel Small Molecular BOC26P in Breast Cancer." Journal of Pharmaceutical and Biomedical Sciences 10, no. 06 (2020): 140–50. https://doi.org/10.5281/zenodo.3941506.

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<em><strong>Background </strong></em>To explore the pharmacodynamic evaluation and mechanism research of BOC26P against breast cancer, and to provide a basis for the treatment of breast cancer. <em><strong>Method</strong></em> MTT assay was used to detect the cytotoxicity of BOC26P against 4 breast cancer cell lines (MCF-7/TAX, MDA-MB-231/PT, MDA-MB-231and MCF-7), and as well as the non-tumor cell lines MCF-10A, in various drug concentrations (from 0.004 to 1 μM). Western Blotting and Real-Time PCR assay were used to detect the relative protein and gene expression level after treatment with

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2

Lina, Lin, Chen Lexing, Xu Jun, Cai Shaohui, and Lu Danyi. "Developing an UPLC-MSMS Method to Quantify a Novel Anticancer Chalcone BOC26P for Its Pharmacokinetic Study In vivo." Journal of Pharmaceutical and Biomedical Sciences 09, no. 08 (2019): 80–92. https://doi.org/10.5281/zenodo.3362987.

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<em>Objective </em>BOC26P is a potent anticancer candidate which inhibits microtubule polymerization and shows strong cytotoxic activity against numerous cancer cell lines and drug resistant cell lines. To support the pharmacokinetic study of BOC26P, a rapid, selective and reproducible UPLC-MS/MS method was developed. <em>Method</em> Dexamethasone sodium phosphate (DSP) was used as an internal standard (IS). Following protein precipitation by using methanol-acetonitrile solution (1:1, v/v) with an internal standard DSP, the processed samples were chromatographed on an UPLC X Bridge 71 <sup>TM<

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Zhu, Cuige, Ruimin Wang, Weichao Zheng, et al. "Synthesis and evaluation of anticancer activity of BOC26P, an ortho-aryl chalcone sodium phosphate as water-soluble prodrugs in vitro and in vivo." Biomedicine & Pharmacotherapy 96 (December 2017): 551–62. http://dx.doi.org/10.1016/j.biopha.2017.10.006.

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Letesson, J. J., and A. Bensaid. "Bovine CD6 (BoCD6)." Veterinary Immunology and Immunopathology 27, no. 1-3 (1991): 61–64. http://dx.doi.org/10.1016/0165-2427(91)90080-v.

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Mohapatra, Debendra K. "Di-tert-butyl Dicarbonate (Boc-anhydride, Boc2O)." Synlett 2001, no. 12 (2001): 1995–96. http://dx.doi.org/10.1055/s-2001-18768.

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6

Kalashnikov, Vyacheslav V., Francisco Benita, and Patrick Mehlitz. "The Natural Gas Cash-Out Problem: A Bilevel Optimal Control Approach." Mathematical Problems in Engineering 2015 (2015): 1–17. http://dx.doi.org/10.1155/2015/286083.

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The aim of this paper is threefold: first, it formulates the natural gas cash-out problem as a bilevel optimal control problem (BOCP); second, it provides interesting theoretical results about Pontryagin-type optimality conditions for a general BOCP where the upper level boasts a Mayer-type cost function and pure state constraints, while the lower level is a finite-dimensional mixed-integer programming problem with exactly one binary variable; and third, it applies these theoretical results in order to find possible local minimizers of the natural gas cash-out problem.

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Nagarajan, M. "Boc2O mediated macrolactonisation: Formal chemoenzymatic synthesis of macrolide antibiotic (−) A26771B." Tetrahedron Letters 40, no. 6 (1999): 1207–10. http://dx.doi.org/10.1016/s0040-4039(98)02567-2.

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Trocha, Aleksandra, Dorota G. Piotrowska, and Iwona E. Głowacka. "Synthesis of Enantiomerically Pure N-Boc-Protected 1,2,3-Triaminopropylphosphonates and 1,2-Diamino-3-Hydroxypropylphosphonates." Molecules 24, no. 21 (2019): 3857. http://dx.doi.org/10.3390/molecules24213857.

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All possible isomers of 1,2,3-tri(N-tert-butoxycarbonylamino)propylphosphonate 6 were synthesized from the respective diethyl [N-(1-phenylethyl)]-1-benzylamino-2,3-epiiminopropylphosphonates 5 via opening the aziridine ring with trimethylsilyl azide (TMSN3) followed by hydrogenolysis in the presence of di-tert-butyl dicarbonate (Boc2O). [N-(1-phenylethyl)]-1-benzylamino-2,3-epiiminopropylphosphonates (1R,2R,1′S)-5a and (1S,2S,1′R)-5c were smoothly transformed into diethyl 3-acetoxy-1-benzylamino-2-[N-(1-phenylethyl)amino]propylphosphonates (1R,2R,1′S)-9a and (1S,2S,1′R)-9c, respectively by the

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Tomasini, Michele, Lucia Caporaso, Michal Szostak, and Albert Poater. "Towards the activity of twisted acyclic amides." RSC Advances 15, no. 11 (2025): 8207–12. https://doi.org/10.1039/d5ra00229j.

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Vasanthakumar, Ganga-Ramu, Basanagoud S. Patil та Vommina V. Suresh Babu. "Homologation of α-amino acids to β-amino acids using Boc2O". J. Chem. Soc., Perkin Trans. 1, № 18 (2002): 2087–89. http://dx.doi.org/10.1039/b204652k.

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11

LUO, Shao-Lan, Xiao-Ping LIAN, Min PU, et al. "Molecular Cloning, Location and Expression Analysis of Brasscia oleracea Zinc Finger Protein Transcription Factor BoC2H2." Acta Agronomica Sinica 44, no. 11 (2018): 1650. http://dx.doi.org/10.3724/sp.j.1006.2018.01650.

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12

Tao, Jiasi, Weijie Yu, Jin Luo, et al. "Na2CO3-promoted thioesterification via N–C bond cleavage of amides to construct thioester derivatives." Journal of Chemical Research 43, no. 11-12 (2019): 486–92. http://dx.doi.org/10.1177/1747519819873514.

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A mild, efficient, and transition-metal-free catalytic strategy is developed to construct thioesters via selective N–C bond cleavage of Boc2-activated primary amides. This strategy is successfully carried out with stoichiometric Na2CO3 as the base and provides the corresponding products in moderate to excellent yields.

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Béczi, Eliézer, and Noémi Gaskó. "Approaching the bi-objective critical node detection problem with a smart initialization-based evolutionary algorithm." PeerJ Computer Science 7 (October 21, 2021): e750. http://dx.doi.org/10.7717/peerj-cs.750.

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Determining the critical nodes in a complex network is an essential computation problem. Several variants of this problem have emerged due to its wide applicability in network analysis. In this article we study the bi-objective critical node detection problem (BOCNDP), which is a new variant of the well-known critical node detection problem, optimizing two objectives at the same time: maximizing the number of connected components and minimizing the variance of their cardinalities. Evolutionary multi-objective algorithms (EMOA) are a straightforward choice to solve this type of problem. We prop

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Nagarajan, M. "ChemInform Abstract: Boc2O-Mediated Macrolactonization: Formal Chemoenzymatic Synthesis of Macrolide Antibiotic (-) A26771B." ChemInform 30, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199922230.

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15

Umehara, Atsushi, Hirofumi Ueda, and Hidetoshi Tokuyama. "Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O." Journal of Organic Chemistry 81, no. 22 (2016): 11444–53. http://dx.doi.org/10.1021/acs.joc.6b02097.

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Ullah, Fateh, Sun Qian, Weitao Yang, et al. "Donor-acceptor (D-A) terpolymers based on alkyl-DPP and t -BocDPP moieties for polymer solar cells." Chinese Chemical Letters 28, no. 12 (2017): 2223–26. http://dx.doi.org/10.1016/j.cclet.2017.08.009.

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Choi, Jong-Soo, Jae-Won Park, Bieong-Kil Kim, Kyung-Oh Doh, and Young-Bae Seu. "A Facile and Convenient Synthesis of Boc-Protected 5-Carboxyspermine." Letters in Organic Chemistry 16, no. 8 (2019): 615–18. http://dx.doi.org/10.2174/1570178615666181022143627.

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Gene therapy is a powerful technology for treating incurable and hereditary disease in humans. In the recent years, a lot of studies have been done on the development of DNA carriers. Nonviral vectors, like liposomes, polymers, and micelles, has become common vehicles due to their safety. The key compound of DOGS, DOSPA and DOSPER is the 5-carboxyspermine which formed the poly amine head-group and carries four positive charges. In general, multivalent head-group shows more transfection efficiency than monovalent analogues. In this paper, the efficient and simple synthesis of Boc-protected 5-ca

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18

Vilaivan, Tirayut. "A rate enhancement of tert-butoxycarbonylation of aromatic amines with Boc2O in alcoholic solvents." Tetrahedron Letters 47, no. 38 (2006): 6739–42. http://dx.doi.org/10.1016/j.tetlet.2006.07.097.

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19

Nagarajan, M. "BoC2O Mediated Macrolactonisation: Syntheses of R-(+)-Ricinoleic Acid Lactone and (±)-12-OH-Stearic Acid Lactone." Synthetic Communications 29, no. 14 (1999): 2467–75. http://dx.doi.org/10.1080/00397919908086253.

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Grigorieva, Ellina, and Evgenii Khailov. "Optimal Strategies for Psoriasis Treatment." Mathematical and Computational Applications 23, no. 3 (2018): 45. http://dx.doi.org/10.3390/mca23030045.

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Within a given time interval we consider a nonlinear system of differential equations describing psoriasis treatment. Its phase variables define the concentrations of T-lymphocytes, keratinocytes and dendritic cells. Two scalar bounded controls are introduced into this system to reflect medication dosages aimed at suppressing interactions between T-lymphocytes and keratinocytes, and between T-lymphocytes and dendritic cells. For such a controlled system, a minimization problem of the concentration of keratinocytes at the terminal time is considered. For its analysis, the Pontryagin maximum pri

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Molina, Pedro, Mateo Alajarin, Pilar Sanchez-Andrada, Jose Elguero, and Maria Luisa Jimeno. "A New and Efficient Preparation of Cyclic Carbodiimides from Bis(iminophosphoranes) and the System Boc2O/DMAP." Journal of Organic Chemistry 59, no. 24 (1994): 7306–15. http://dx.doi.org/10.1021/jo00103a022.

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22

Gavins, Felicity N. E., Simon Yona, Ahmad M. Kamal, Roderick J. Flower, and Mauro Perretti. "Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms." Blood 101, no. 10 (2003): 4140–47. http://dx.doi.org/10.1182/blood-2002-11-3411.

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Abstract Recent investigations conducted with human neutrophils have indicated an involvement for the receptor for formylated peptides, termed FPR, and its analog FPRL1 (or ALXR because it is the receptor for the endogenous ligand lipoxin A4) in the in vitro inhibitory actions of the glucocorticoid-regulated protein annexin 1 and its peptidomimetics. To translate these findings in in vivo settings, we have used an ischemia/reperfusion (I/R) procedure to promote leukocyte-endothelium interactions in the mouse mesenteric microcirculation. In naive mice, the annexin 1 mimetic peptide Ac2-26 (20 t

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23

Nagarajan, M. "ChemInform Abstract: Boc2O Mediated Macrolactonization: Syntheses of R-(+)-Ricinoleic Acid Lactone and (.+-.)-12-OH-Stearic Acid Lactone." ChemInform 30, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199936268.

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24

Djema, Walid, Térence Bayen, and Olivier Bernard. "Optimal Darwinian Selection of Microorganisms with Internal Storage." Processes 10, no. 3 (2022): 461. http://dx.doi.org/10.3390/pr10030461.

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In this paper, we investigate the problem of species separation in minimal time. Droop model is considered to describe the evolution of two distinct populations of microorganisms that are in competition for the same resource in a photobioreactor. We focus on an optimal control problem (OCP) subject to a five-dimensional controlled system in which the control represents the dilution rate of the chemostat. The objective is to select the desired species in minimal-time and to synthesize an optimal feedback control. This is a very challenging issue, since we are are dealing with a ten-dimensional

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Khailov, Evgenii, Ellina Grigorieva, and Anna Klimenkova. "Optimal CAR T-cell Immunotherapy Strategies for a Leukemia Treatment Model." Games 11, no. 4 (2020): 53. http://dx.doi.org/10.3390/g11040053.

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CAR T-cell immunotherapy is a new development in the treatment of leukemia, promising a new era in oncology. Although so far, this procedure only helps 50–90% of patients and, like other cancer treatments, has serious side effects. In this work, we have proposed a controlled model for leukemia treatment to explore possible ways to improve immunotherapy methodology. Our model is described by four nonlinear differential equations with two bounded controls, which are responsible for the rate of injection of chimeric cells, as well as for the dosage of the drug that suppresses the so-called “cytok

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26

Mardiah, Siti. "FASILITASI PERDAGANGAN DAN EKSPOR MANUFAKTUR UNGGULAN INDONESIA KE RCEP." Jurnal BPPK : Badan Pendidikan dan Pelatihan Keuangan 13, no. 1 (2020): 15–32. http://dx.doi.org/10.48108/jurnalbppk.v13i1.388.

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Fasilitasi perdagangan telah menjadi perhatian berbagai negara dan berperan penting dalam efisiensi perdagangan. Manufaktur adalah salah satu produk eskpor yang memiliki peran penting bagi perekonomian Indonesia. Namun nilai ekspor manufaktur Indonesia ke RCEP selama periode 2012-2016 mengalami penurunan. Penelitian ini bertujuan menganalisis sektor unggulan manufaktur Indonesia dan menganalisis dampak fasilitasi perdagangan terhadap ekspor manufaktur unggulan Indonesia ke RCEP. Data yang digunakan adalah data sekunder periode 2012-2016 dengan metode analisis Revealed Comparative Advantage (RC

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MOLINA, P., M. ALAJARIN, P. SANCHEZ-ANDRADA, J. ELGUERO, and M. L. JIMENO. "ChemInform Abstract: A New and Efficient Preparation of Cyclic Carbodiimides from Bis( iminophosphoranes) and the System Boc2O/DMAP." ChemInform 26, no. 28 (2010): no. http://dx.doi.org/10.1002/chin.199528188.

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Ariza, Xavier, Oriol Pineda, Felix Urpi, and Jaume Vilarrasa. "ChemInform Abstract: From Vicinal Azido Alcohols to Boc-Amino Alcohols or Oxazolidinones, with Trimethylphosphine and Boc2O or CO2." ChemInform 32, no. 42 (2010): no. http://dx.doi.org/10.1002/chin.200142112.

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Shybanov, Dmitry E., Maxim E. Kukushkin, Yanislav S. Hrytseniuk, et al. "[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones." International Journal of Molecular Sciences 24, no. 5 (2023): 5037. http://dx.doi.org/10.3390/ijms24055037.

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Novel hydantion and thiohydantoin-based spiro-compounds were prepared via theDiels–Alder reactions between 5-methylidene-hydantoins or 5-methylidene-2-thiohydantoins and 1,3-dienes (cyclopentadiene, cyclohexadiene, 2,3-dimethylbutadiene, isoprene). It was shown that the cycloaddition reactions proceed regioselectively and stereoselectively with the formation of exo-isomers in the reactions with cyclic dienes andthe less sterically hindered products in the reactions with isoprene. Reactions of methylideneimidazolones with cyclopentadiene proceed viaco-heating the reactants; reactions with cyclo

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Lalithamba, H. S., та Vommina V. Sureshbabu. "ChemInform Abstract: Simple and Efficient Synthesis of Fmoc/Boc/Cbz-Protected-β-amino Alcohols and Peptidyl Alcohols Employing Boc2O." ChemInform 42, № 11 (2011): no. http://dx.doi.org/10.1002/chin.201111205.

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RodrÍguez-Leyva, Esteban, Jorge L. Leyva, Victoria Gómez, Nina M. Bárcenas, and Gary W. Elzen. "Biology of Catolaccus hunteri (Hymenoptera: Pteromalidae), A Parasitoid of Pepper Weevil and Boll Weevil (Coleoptera: Curculionidae)." Annals of the Entomological Society of America 93, no. 4 (2000): 862–68. http://dx.doi.org/10.1603/0013-8746(2000)093[0862:bochhp]2.0.co;2.

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Carr, Katherine H., Gerald T. Coyle, and Richard A. Kimerle. "BIOCONCENTRATION OF [14C]BUTYL BENZYL PHTHALATE IN BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS)." Environmental Toxicology and Chemistry 16, no. 10 (1997): 2200. http://dx.doi.org/10.1897/1551-5028(1997)016<2200:bocbbp>2.3.co;2.

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Topuzyan, V. O., A. S. �dilyan, and O. L. Mndzhoyan. "Choline esters of N-substituted aminoacids. III. The system Boc2O-pyridine as a reagent for synthesis of ?-diethylaminoethyl esters of N-substituted acids." Pharmaceutical Chemistry Journal 24, no. 4 (1990): 237–40. http://dx.doi.org/10.1007/bf00764406.

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Malvezi, Aparecida Donizette, Rosiane Valeriano da Silva, Carolina Panis, et al. "Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry ofTrypanosoma cruziin Mouse Peritoneal Macrophages." Mediators of Inflammation 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/580919.

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The intracellular protozoan parasiteTrypanosoma cruzicauses Chagas disease, a serious disorder that affects millions of people in Latin America. Cell invasion byT. cruziand its intracellular replication are essential to the parasite’s life cycle and for the development of Chagas disease. Here, we present evidence suggesting the involvement of the host’s cyclooxygenase (COX) enzyme duringT. cruziinvasion. Pharmacological antagonist for COX-1, aspirin (ASA), caused marked inhibition ofT. cruziinfection when peritoneal macrophages were pretreated with ASA for 30 min at 37°C before inoculation. Th

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Grigorieva, Ellina V., Evgenii N. Khailov, and Andrei Korobeinikov. "Optimal Controls of the Highly Active Antiretroviral Therapy." Abstract and Applied Analysis 2020 (February 1, 2020): 1–23. http://dx.doi.org/10.1155/2020/8107106.

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In this paper, we study generic properties of the optimal, in a certain sense, highly active antiretroviral therapy (or HAART). To address this problem, we consider a control model based on the 3-dimensional Nowak–May within-host HIV dynamics model. Taking into consideration that precise forms of functional responses are usually unknown, we introduce into this model a nonlinear incidence rate of a rather general form given by an unspecified function of the susceptible cells and free virus particles. We also add a term responsible to the loss of free virions due to infection of the target cells

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Sampaio-Dias, Ivo E., Sara C. Silva-Reis, Luís Pinto da Silva, Xerardo García-Mera, Miguel A. Maestro, and José E. Rodríguez-Borges. "Mechanistic insights for the transprotection of tertiary amines with Boc2O via charged carbamates: access to both enantiomers of 2-azanorbornane-3-exo-carboxylic acids." Organic Chemistry Frontiers 6, no. 20 (2019): 3540–54. http://dx.doi.org/10.1039/c9qo00957d.

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Development of a synthetic methodology for the selective transprotection in hindered tertiary amines using Boc<sub>2</sub>O under N–C hydrogenolysis catalyzed by Pd/C: access to both enantiomers of 2-azanorbornane-3-exo-carboxylates.

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Bartoli, Giuseppe, Marcella Bosco, Manuela Locatelli, Enrico Marcantoni, Paolo Melchiorre, and Letizia Sambri. "Unusual and Unexpected Reactivity oft-Butyl Dicarbonate (Boc2O) with Alcohols in the Presence of Magnesium Perchlorate. A New and General Route tot-Butyl Ethers." Organic Letters 7, no. 3 (2005): 427–30. http://dx.doi.org/10.1021/ol047704o.

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Nawaz, Imtiaz M., Paola Chiodelli, Sara Rezzola, et al. "N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) inhibits the angiogenic activity of heparin-binding growth factors." Angiogenesis 21, no. 1 (2017): 47–59. http://dx.doi.org/10.1007/s10456-017-9581-6.

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Badescu, Viorel. "Self-Driven Reverse Thermal Engines Under Monotonous and Oscillatory Optimal Operation." Journal of Non-Equilibrium Thermodynamics 46, no. 3 (2021): 291–319. http://dx.doi.org/10.1515/jnet-2020-0103.

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Abstract The complex time-dependent heat and electromagnetic energy transfer in a new type of reverse thermal engine is analyzed. The reverse thermal engine consists of a cold body, a Peltier element and an electric circuit containing an inductor with controllable inductance. This system allows cooling a body below the ambient temperature. The inductor acts as an accumulator of magnetic energy, receiving electrical work from the Peltier element during some time intervals and supplying the Peltier element with electrical work during other time intervals. The system is named self-driven reverse

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Chen, Yini, and Ting Chi. "How Does Channel Integration Affect Consumers’ Selection of Omni-Channel Shopping Methods? An Empirical Study of U.S. Consumers." Sustainability 13, no. 16 (2021): 8983. http://dx.doi.org/10.3390/su13168983.

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In recent years, fashion brands and retailers have been advancing rapidly to provide U.S. consumers more seamless omni-channel shopping experiences. The pandemic has further accelerated the growth of omni-channel shopping. This study aimed to explore the effects of channel integration in six aspects (i.e., promotion, product and price, transaction information, information access, order fulfillment, and customer service) on the U.S. consumers’ intentions to use three omni-channel shopping methods: buy online pick-up in-store (BOPI), buy online curbside pickup (BOCP), and buy in-store home deliv

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Rezzola, Sara, Jessica Guerra, Adwaid Manu Krishna Chandran, et al. "VEGF-Independent Activation of Müller Cells by the Vitreous from Proliferative Diabetic Retinopathy Patients." International Journal of Molecular Sciences 22, no. 4 (2021): 2179. http://dx.doi.org/10.3390/ijms22042179.

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Proliferative diabetic retinopathy (PDR), a major complication of diabetes mellitus, results from an inflammation-sustained interplay among endothelial cells, neurons, and glia. Even though anti-vascular endothelial growth factor (VEGF) interventions represent the therapeutic option for PDR, they are only partially efficacious. In PDR, Müller cells undergo reactive gliosis, produce inflammatory cytokines/chemokines, and contribute to scar formation and retinal neovascularization. However, the impact of anti-VEGF interventions on Müller cell activation has not been fully elucidated. Here, we sh

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Lice, Izabella, José Marcos Sanches, Rebeca D. Correia-Silva, et al. "Effects of Formyl Peptide Receptor Agonists Ac9-12 and WKYMV in In Vivo and In Vitro Acute Inflammatory Experimental Models." Cells 11, no. 2 (2022): 228. http://dx.doi.org/10.3390/cells11020228.

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Formyl peptide receptors (Fprs) are a G-protein-coupled receptor family mainly expressed on leukocytes. The activation of Fpr1 and Fpr2 triggers a cascade of signaling events, leading to leukocyte migration, cytokine release, and increased phagocytosis. In this study, we evaluate the effects of the Fpr1 and Fpr2 agonists Ac9-12 and WKYMV, respectively, in carrageenan-induced acute peritonitis and LPS-stimulated macrophages. Peritonitis was induced in male C57BL/6 mice through the intraperitoneal injection of 1 mL of 3% carrageenan solution or saline (control). Pre-treatments with Ac9-12 and WK

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Rossi, S., C. Di Filippo, C. Gesualdo, et al. "Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats." Mediators of Inflammation 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/126408.

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Rat endotoxin-induced uveitis (EIU) is a well-established model of human uveitis. In this model, intravitreal injection of resolvin D1 (RvD1, 10–100–1000 ng/kg) 1 hour after subcutaneous treatment of Sprague-Dawley rats with lipopolysaccharide (LPS, 200 μg/rat) significantly prevented the development of uveitis into the eye. RvD1 dose-dependently increased the expression of sirtuin-1 (SIRT1) within the eye, while it decreased the expression of acetyl-p53 and acetyl-FOXO1. These effects were accompanied by local downregulation of some microRNAs related to the expression and activity of SIRT1. T

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Saito, Yukako, Tomokazu Watanabe, and Hiroki Takahata. "A novel 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI)-catalyzed esterification of N-protected amino acids with nearly equimolar amounts of alcohols in the presence of Boc2O." Tetrahedron Letters 47, no. 18 (2006): 3099–102. http://dx.doi.org/10.1016/j.tetlet.2006.02.149.

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Martin, Gary R., Mauro Perretti, Roderick J. Flower, and John L. Wallace. "Annexin-1 modulates repair of gastric mucosal injury." American Journal of Physiology-Gastrointestinal and Liver Physiology 294, no. 3 (2008): G764—G769. http://dx.doi.org/10.1152/ajpgi.00531.2007.

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Annexin-1 is a glucocorticoid-inducible protein that plays an important effector role in the resolution of inflammation and has recently been shown to contribute to the resistance of the stomach to injury. Using an integrated genetic and pharmacological approach, we have tested the hypothesis that annexin-1 contributes to the healing of mucosal injury, given that such injury is accompanied by an inflammatory response, which is often associated with an overexpression of annexin-1 expression. Gastric ulcers were induced in mice through serosal application of acetic acid. Annexin-1 expression dur

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Buchanan, Paul J., Paul McNally, Brian J. Harvey, and Valerie Urbach. "Lipoxin A4-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair." American Journal of Physiology-Lung Cellular and Molecular Physiology 305, no. 2 (2013): L193—L201. http://dx.doi.org/10.1152/ajplung.00058.2013.

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The main cause of morbidity and mortality in cystic fibrosis (CF) is progressive lung destruction as a result of persistent bacterial infection and inflammation, coupled with reduced capacity for epithelial repair. Levels of the anti-inflammatory mediator lipoxin A4 (LXA4) have been reported to be reduced in bronchoalveolar lavages of patients with CF. We investigated the ability of LXA4 to trigger epithelial repair through the initiation of proliferation and migration in non-CF (NuLi-1) and CF (CuFi-1) airway epithelia. Spontaneous repair and cell migration were significantly slower in CF epi

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Li, Guangchen, and Michal Szostak. "Synthesis of biaryl ketones by arylation of Weinreb amides with functionalized Grignard reagents under thermodynamic control vs. kinetic control of N,N-Boc2-amides." Organic & Biomolecular Chemistry 18, no. 20 (2020): 3827–31. http://dx.doi.org/10.1039/d0ob00813c.

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A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N-methylamides) with functionalized Grignard reagents after Mg/halide exchange with i-PrMgCl·LiCl is reported.

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Dong, Peng, Wei Xiong, Jin Feng та ін. "Enzymatic Synthesis of Poly(β‐Amino Ester) Copolymer With High Potency in Eliminating Gram‐Negative Bacteria". Macromolecular Rapid Communications, 6 березня 2025. https://doi.org/10.1002/marc.202400885.

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AbstractThe functional lactone 2‐Methyl‐2‐propanyl‐7‐oxo‐1,4‐oxazepane‐4‐carboxylate (BocOP), containing a protected secondary amino group, is synthesized through oxone‐mediated Baeyer‐Villiger oxidation. After that, the homopolymerization kinetics of BocOP catalyzed by immobilized Candida antarctia lipase B (Novozym 435, N435) are investigated. The N435 can efficiently catalyze the conversion of BocOP into poly(β‐amino ester) (PAE). Then, the N435 is subsequently employed to synthesize copolymers of BocOP and ε‐caprolactone (CL) using methoxypolyethylene glycols (mPEG) as initiators. The stud

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Boukachabia, Mourad, Mounia Merabet-Khelassi, and Olivier Riant. "Condensation of carboxylic acids with amines using the Boc₂O/DMAP system under solvent-free conditions." Organic & Biomolecular Chemistry, 2025. https://doi.org/10.1039/d4ob01868k.

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An, Biyu, Zixin Lin, Jiawei Liu, Qinghua Bian, Min Wang, and Jiangchun Zhong. "Asymmetric Synthesis of (S)-14-Methyl-1-octadecene, the Sex Pheromone of Lyonetia clerkella Linnaeus." Chemistry Letters, February 22, 2024. http://dx.doi.org/10.1093/chemle/upae033.

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Abstract Lyonetia clerkella Linnaeus is one of notorious pests in orchards. A new and efficient asymmetric synthesis of the sex pheromone of this pest has been developed. The central to this approach involved DMAPO/Boc2O-mediated N-acylation, Evans’ chiral auxiliaries and the coupling of chiral tosylate with n-propyl magnesium bromide. Furthermore, we have demonstrated the scalability of the new acylation.

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