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Dissertations / Theses on the topic 'Bone cells Metabolism'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Mason, Rachel Ann. "Effects of estrogens and androgens on bone cell metabolism /." Title page, table of contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phm411.pdf.

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2

Secreto, Frank. "The regulation of arachidonic acid metabolism in human osteoblast-like cells." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2970.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vi, 123 p. : ill. Includes abstract. Includes bibliographical references (p. 110-123).

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3

Macoritto, Michael. "Mechanisms of vitamin D receptor and retinoid X receptor mediated hormone resistance and cell differentiation in normal and cancer cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111887.

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Vitamin D is a precursor to a steroid hormone, 1,25 dihydroxyvitamin D (1,25(OH)2D). After its discovery and the characterization of its receptor, the vitamin D receptor (VDR), it was initially thought only to be involved in calcium homeostasis, but further research revealed an important role for vitamin D in the regulation of cell growth and differentiation of such cells as osteoblasts and bone marrow adipocytes. 1,25(OH)2D has also been shown to be a strong inhibitor and pro-differentiator of keratinocytes. The anti-proliferative and pro-differentiative properties of this hormone have led to

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4

Star, Gregory. "The effects of bone morphogenic proteins and transforming growth factor [beta] on in-vitro endothelin-1 production by human pulmonary microvascular endothelial cells /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111942.

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Introduction: Idiopathic Pulmonary arteriole hypertension (IPAH) is a rare but severely debilitating disease that strikes women to men at a ratio of 3:1. Endothelial cell (EC) dysfunction is a hallmark of the disease. This includes rapid growth of the ECs until the occlusion of the vasculature as well as decreased blood levels of vasodilators. Markedly increased levels of endothelin-1, a potent vasoconstrictor and smooth muscle mitogen, have been noted in IPAH patients.<br>Recently mutations in the bone morphogenic protein receptor type II (BMPRII) have been linked to the disease. Interestingl

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5

Ren, Song. "Metabolism of cyclophosphamide : implications for hematopoietic stem cell transplantation /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7968.

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6

Pan, Beiqing. "Mechanisms of skeletal disease mediated by haematological malignancies /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09php1871.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine and The Hanson Centre, Institute of Medical and Veterinary Science, 2004.<br>"August 2004" Errata inside front cover. Bibliography: leaves 126-159.

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7

Zarrinkalam, Krystyna. "Characterisation of osteoblast function in a feline model of mucopolysaccharidosis type VI." Title page, contents and introduction only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phz38.pdf.

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Addenda slip inserted in back. Includes bibliographical references (leaves 178-231). To further the understanding of the molecular mechanisms that contribute to the skeletal pathology of mucopolysaccharidosis type VI and to investigate the production of organic matrix by mucopolysaccharidosis VI osteoblasts

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8

Pan, Beiqing. "Molecular and cellular studies of zoledronic acid : a potent inhibitor of multiple myeloma-induced osteolysis." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09MSM/09msmp187.pdf.

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Bibliography: leaves 86-103. Investigates the effect of zoledronic acid on myeloma cells and osteoblast-like cells to establish the molecular and cellular mechanisms responsible for the clinical effectiveness of bisphosphonates in the treatment of patients with myelomatosis. Concludes that zoledronic acid inhibits myelomatosis-induced osteolysis thorugh the mechanisms of myeloma cell death and proliferation and maturation of osteoblasts.

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9

Freitas, Claudia Mercedes. "Regulation of Immune Cell Activation and Functionby the nBMPp2 Protein andthe CD5 Co-Receptor." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8257.

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According to the centers for disease control and prevention (CDC) and the world healthorganization (WHO), heart disease and immune related diseases such as diabetes and cancer areamong the leading causes of death around the world. Thus, the regulation of the function ofimmune cell plays a key role in health and disease. Calcium (Ca2+) ions play a critical role inimmune cell activation, function and in a robust immune response. Defects in Ca2+ signalinginfluences the development of cardiac disease, Alzheimer disease, immune cell metabolism,muscle dysfunction, and cancer. Each immune cell is uni

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10

Laketic-Ljubojevic, Ira. "Glutamate signalling in bone cells." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311080.

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11

Hayes, Sandra C. "Exercise, functional capacity and quality of life in peripheral blood stem cell transplant patients." Thesis, Queensland University of Technology, 2001. https://eprints.qut.edu.au/36758/7/36758_Digitised%20Thesis.pdf.

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12

Rondeau, Vincent. "Rôle de la désensibilisation de CXCR4 dans la spécification lympho-myéloïde des progéniteurs hématopoïétiques multipotents. Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization New method to obtain lymphoid progenitors CXCR4-driven mitochondrial metabolic pathways shape the lympho-myeloid fate of hematopoietic multipotent progenitors." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ022.

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Les cellules souches et progéniteurs hématopoïétiques (CSPHs), incluant les progéniteurs multipotents (MPPs), sont responsables de la production des cellules immunes circulantes. Ils résident dans la moelle osseuse (MO) au sein de structures spécialisées, les niches endostéale et (péri)-vasculaire, qui régulent la spécification et l'engagement lymphoïde versus myéloïde des CSPHs. Dans la MO, le couple formé par la chimiokine CXCL12 et l’un de ses récepteurs, CXCR4, exerce un rôle clé dans la régulation de la rétention et la quiescence des CSPHs. Ces processus sont dérégulés dans le Syndrome WH

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13

Mason, Shelley S. "Exploring Tissue Engineering: Vitamin D3 Influences on the Proliferation and Differentiation of an Engineered Osteoblast Precursor Cell Line During Early Bone Tissue Development." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1000.

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Most of the load-bearing demand placed on the human body is transduced by skeletal tissue, and the capacity of the skeleton to articulate in various opposing directions is essential for body movement and locomotion. Consequently, cartilage and bone defects due to trauma, disease, and developmental abnormalities result in disabling pain and immobility for millions of people worldwide. A novel way of promoting cartilage and bone regeneration is through the incorporation of either primary cells or multipotent progenitor cells in a three-dimensional (3D) biomaterial scaffold, and/or the addition o

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14

Ford, Lorna. "An investigation into the effects of endocannabinoids and the COX-2 metabolite of 2-Arachidonyl glycerol on bone cells." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=33596.

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15

Mason, Rachel Ann. "Effects of estrogens and androgens on bone cell metabolism / Rachel Ann Mason." Thesis, 1997. http://hdl.handle.net/2440/19065.

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Bibliography: leaves 298-334.<br>xxxi, 334, [3] leaves, [18] leaves of plates : ill. ; 30 cm.<br>Provides insight into the mechanism by which dihydrotestosterone (DHT) and estrogen effect osteoblast and osteoclast bone cell activities. Also demonstrates the differential effects of DHT on bone cell activities in estrogen sufficient and estrogen deficient rats suggesting that there is an interaction of estrogens and androgens on bone cell metabolism in the female rat.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1998?

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16

Corry, Kylie A. "Novel insights into the mechanistic gene regulation of STAT3 in bone cells." Thesis, 2015. http://hdl.handle.net/1805/7956.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Many cells are involved in the orchestra that is bone homeostasis--particularly osteoclasts and osteoblasts, which mediate remodeling of bones. This creates a balance that must be kept in check, otherwise pathologies arise. The JAK-STAT signaling pathway is crucial to maintaining this balance. It has long been known that the transcription factor STAT3 has more profound effects on bone homeostasis than other members of the STAT family of proteins. Recently, a genetic condition called Job’s Syndrome has been specifically linked to poin

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17

Anuradha, Valiya Kambrath. "Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism." Thesis, 2015. http://hdl.handle.net/1805/7942.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The Cre/loxP system is a tool for targeted recombination of DNA. For applying Cre recombinase-mediated genome modifications, there is a requirement for reliable, high-fidelity, and specific transgenic expression of the Cre recombinase. This study focuses on the reliability of different bone cell specific Cre models in the Cre/loxP system. In this study, DMP1-Cre transgenic mouse which has a transgene driven by DMP1 promotor that allows Cre-expression only in late stage osteoblasts and osteocytes was used. Ctsk-Cre mouse with a driven

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18

Algate, Kent. "Epigenetic Regulation of Cells Involved in Periodontal Bone Destruction through Targeted Histone Deacetylase Inhibition." Thesis, 2018. http://hdl.handle.net/2440/127113.

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Periodontitis (PD) is one of the most common bone loss pathologies in adults and currently affects more than 60% of the population in its destructive form. Ineffective or surgically invasive treatment options can result in patient noncompliance, gingival recession, alveolar bone destruction and eventual loss of teeth. Aside from the psychosocial effects of poor dental health, PD has been associated with a variety of systemic conditions, such as rheumatoid arthritis and cardiovascular disease, exacerbating their onset and severity. Histone deacetylase (HDAC) enzymes are molecules that control c

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19

Pan, Beiqing. "Mechanisms of skeletal disease mediated by haematological malignancies / Beiqing Pan." Thesis, 2004. http://hdl.handle.net/2440/22124.

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"August 2004"<br>Errata inside front cover.<br>Bibliography: leaves 126-159.<br>xi, 159, [12] leaves : ill., plates ; 30 cm.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine and The Hanson Centre, Institute of Medical and Veterinary Science, 2004

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20

Singh, Suman K., Waqas A. Abbas, and Desmond J. Tobin. "Bone morphogenetic proteins differentially regulate pigmentation in human skin cells." 2012. http://hdl.handle.net/10454/6194.

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Bone morphogenetic proteins (BMPs) are a large family of multi-functional secreted signalling molecules. Previously BMP2/4 were shown to inhibit skin pigmentation by downregulating tyrosinase expression and activity in epidermal melanocytes. However, a possible role for other BMP family members and their antagonists in melanogenesis has not yet been explored. In this study we show that BMP4 and BMP6, from two different BMP subclasses, and their antagonists noggin and sclerostin were variably expressed in melanocytes and keratinocytes in human skin. We further examined their involvement in mela

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21

Zarrinkalam, Krystyna Helena. "Characterisation of osteoblast function in a feline model of mucopolysaccharidosis type VI / by Krystyna Zarrinkalam." Thesis, 2001. http://hdl.handle.net/2440/21750.

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Addenda slip inserted in back.<br>Includes bibliographical references (leaves 178-231).<br>xiv, 234, [19] leaves, [56] leaves of plates : ill. (chiefly col.) ; 30 cm.<br>To further the understanding of the molecular mechanisms that contribute to the skeletal pathology of mucopolysaccharidosis type VI and to investigate the production of organic matrix by mucopolysaccharidosis VI osteoblasts<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2001

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22

Himes, Evan Robert. "The role of STAT3 in osteoclast mediated bone resorption." Thesis, 2014. http://hdl.handle.net/1805/4841.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Signal Transducer and Activator of Transcription 3 (STAT3) is known to be related to bone metabolism. Mutation of STAT3 causes a rare disorder in which serum levels of IgE are elevated. This causes various skeletal problems similar to osteoporosis. To examine the effect of STAT3 in the osteoclast, we obtained two osteoclast specific STAT3 knockout mouse models: one using the CTSK promoter to drive Cre recombinase and another using a TRAP promoter. Examination of these mice at 8 weeks of age revealed a decreased trabecular bone vo

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23

Zhou, Hongkang. "The essential role of Stat3 in bone homeostasis and mechanotransduction." Thesis, 2014. http://hdl.handle.net/1805/6190.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Signal Transducer and Activator of Transcription 3 (Stat3) is a transcription factor expressed in bone and joint cells that include osteoblasts, osteocytes, osteoclasts, and chondrocytes. Stat3 is activated by a variety of cytokines and growth factors, including IL-6/gp130 family cytokines. These cytokines not only regulate the differentiation of osteoblasts and osteoclasts, but also regulate proliferation of chondrocytes through Stat3 activation. In 2007, mutations of Stat3 have been confirmed to cause a rare human immunodeficiency

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24

Ben-awadh, Abdullah Nasser. "CONTRIBUTION OF RANKL REGULATION TO BONE RESORPTION INDUCED BY PTH RECEPTOR ACTIVATION IN OSTEOCYTES." 2012. http://hdl.handle.net/1805/3015.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>PTH increases osteoclasts by upregulating RANKL in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell remains undefined. Recent findings demonstrate that PTH regulates gene expression in osteocytes and that these cells are an important source of RANKL. We therefore investigated whether direct regulation of the RANKL gene by PTH in osteocytes is required to stimulate osteoclastic bone resorption. To address this question, we examined bone resorption and RANKL expression in transgenic mice

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25

Reis, Sara Daniela de Sousa. "Characterization of the Effects of Proton Pump inhibitors on bone Metabolism: in vitro study in cocultures of osteoclasts and Breast Cancer Cells and in Cultures of Osteoblasts." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/70510.

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26

Reis, Sara Daniela de Sousa. "Characterization of the Effects of Proton Pump inhibitors on bone Metabolism: in vitro study in cocultures of osteoclasts and Breast Cancer Cells and in Cultures of Osteoblasts." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/70510.

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27

"Hyperglycemic impairment of CGRP-induced cAMP responses in vascular smooth muscle cells (VSMCs) and the role of cGMP/protein kinase G pathway in regulating apoptosis and proliferation of VSMCs and bone marrow stromal stem cells." 2006. http://library.cuhk.edu.hk/record=b5893055.

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Wong Cheuk Ying.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 101-124).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>摘要 --- p.iv<br>Acknowledgement --- p.vi<br>List of Abbreviations --- p.vii<br>Chapter Chapter 1. --- General Introduction --- p.1<br>Chapter Chapter 2. --- Methods --- p.4<br>Chapter 2.1 --- Measurement of cAMP and cGMP in VSMCs --- p.4<br>Chapter 2.1.1 --- Cell culture --- p.4<br>Chapter 2.1.2 --- Enzyme-immunoassay colorimetric measurement for cAMP and cGMP --- p.5<br>Chapter 2.1.3 --- Statis

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28

Shakibaei, M., C. Buhrmann, and A. Mobasheri. "Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells." 2011. http://hdl.handle.net/10454/6182.

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Resveratrol is a polyphenolic phytoestrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory, and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activities result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis and osteoporosis. Receptor activator of NF-kappaB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study, we investigated the effects of resveratrol on RANKL during bone morphogenesis in high density bone cultures in

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29

Nasim, Md Talat, T. Ogo, H. M. Chowdhury, L. Zhao, C.-n. Chen, C. Rhodes, and R. C. Trembath. "BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFbeta-TAK1-MAPK pathways in PAH." 2012. http://hdl.handle.net/10454/6115.

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Pulmonary arterial hypertension (PAH) is a cardiovascular disorder associated with enhanced proliferation and suppressed apoptosis of pulmonary arterial smooth muscle cells (PASMCs). Heterozygous mutations in the type II receptor for bone morphogenetic protein (BMPR2) underlie the majority of the inherited and familial forms of PAH. The transforming growth factor beta (TGFbeta) pathway is activated in both human and experimental models of PAH. However, how these factors exert pro-proliferative and anti-apoptotic responses in PAH remains unclear. Using mouse primary PASMCs derived from knock-in

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30

Bonfitto, Anna. "Testing bone cell models responsive to a soluble form of klotho." Thesis, 2016. https://doi.org/10.7912/C2V087.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Fibroblast growth factor-23 (FGF23) is a hormone produced in bone that acts upon the kidney to control blood phosphate and 1,25-(OH)2 vitamin D concentrations. Chronic kidney disease-mineral bone disorder (CKD-MBD) is a major public health problem, affecting 1 in 8 individuals. These patients can have markedly elevated FGF23 at end stage disease which is associated with metabolic bone anomalies, left ventricular hypertrophy, as well as increased mortality (>6-fold). The FGF23 co-receptor αKlotho (αKL) is a membrane-bound protein (

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31

Sun, Shih-Chun, and 孫詩淳. "Effects of Di(2-ethylhexyl) Phthalate and Its Metabolite on Osteoblast and Adipocyte Differentiation from Mouse Bone Marrow-derived Mesenchymal Stem Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/08496907133769368336.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>102<br>Di(2-ethylhexyl) Phthalate (DEHP), the most widely used phthalate in Taiwan, is added in polyvinyl chloride plastics to increased flexibility. DEHP is commonly used in medical devices, food package, architectural materials, and surface coating. Besides, DEHP is a well-known endocrine-disrupting chemicals (EDCs). EDCs are estrogenic industrial compound that can disrupt normal hormone signaling systems, which raised considerable concern in recent years. Bone microenvironment is a complex dynamic equilibrium between osteoclasts and osteoblasts and is modulated by

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32

Hum, Julia M. "Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress." Thesis, 2014. http://hdl.handle.net/1805/4652.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Bone is a dynamic organ that responds to its external environment. Cell signaling cascades are initiated within bone cells when changes in mechanical loading occur. To describe these molecular signaling networks that sense a mechanical signal and convert it into a transcriptional response, we proposed the mechanosome model. “GO” and “STOP” mechansomes contain an adhesion-associated protein and a nucleocytoplasmic shuttling transcription factor. “GO” mechanosomes functions to promote the anabolic response of bone to mechanical load

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33

Linhartová, Jana. "Transplantace kadaverozní kostní dřeně: vliv hypoxie a metabolické starvace na myší krvetvorné kmenové buňky." Doctoral thesis, 2012. http://www.nusl.cz/ntk/nusl-307941.

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Objectives: Hematopoietic stem cell transplantation (HSCT) is a widely used method for treatment of hematological disorders and some other diseases. However, sometimes a suitable donor of hematopoietic stem cells (HSC) is not found for a patient. Because HSC have been described as cells with low proliferative and metabolic activity, their tolerance to the lack of oxygen or metabolic substrates may be assumed. In this study, we explored cadaveric bone marrow as an alternative source of HSC for HSCT, using a mouse experimental model. In addition, the effect of in vitro metabolic inhibition and s

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