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Dissertations / Theses on the topic 'Bone cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.

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Breast carcinoma is the most commonly diagnosed cancer among women worldwide, with approximately 1 in 7 expected to be affected during her lifetime. The spread of breast cancer to secondary sites is generally incurable. Bone is the preferred site of metastasis, where the development of a secondary tumour causes severe osteolysis, hypercalcemia and a considerable pain burden. However, how breast cancer cells establish supportive interactions with bone cells is not well understood. We have examined the effects of factors released from MDA-MB-231 and 4T1 breast cancer cells on the differentiation

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2

Hoebertz, Astrid. "Purinergic signalling in bone cells." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249706.

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3

Laketic-Ljubojevic, Ira. "Glutamate signalling in bone cells." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311080.

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4

Malone, Amanda Michelle Dolphin. "Mechanotransduction mechanisms in bone cells /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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5

Porter, Ryan Michael. "Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/36365.

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Long-term exposure to pharmacological doses of glucocorticoids has been associated with the development of osteopenia and avascular necrosis. Bone loss may be partially attributed to a steroid-induced decrease in the osteoblastic differentiation of multipotent progenitor cells found in the bone marrow. In order to determine if there is a change in the osteogenic potential of the bone marrow stroma following glucocorticoid treatment, Sprague-Dawley rats were administered methylprednisolone for up to six weeks, then sacrificed at 0, 2, 4, or 6 weeks during treatment or 4 weeks after cessation

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6

Bennett, Jonathan Hilary. "The differentiation of osteogenic cells from bone marrow." Thesis, University of Oxford, 1991. http://ora.ox.ac.uk/objects/uuid:3460f26e-a124-4605-8601-2e300241de14.

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7

Gronthos, Stan. "Stromal precursor cells : purification and the development of bone tissue." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phg8757.pdf.

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Bibliography: leaves 152-223. Experiments were designed to identify and purify human bone marrow stromal precursor cells by positive immunoselection, based on the cell surface expression of the VCAM-1 and STRO-1 antigens. The data presented demonstrates a hierarchy of bone cell development in vitro.

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8

Kandimalla, Yugandhar. "Study of Chitosan Microparticles with Bone Marrow Mesenchymal Stem Cells for Bone Tissue Regeneration." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1250778129.

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9

Wigzell, Cathy. "Differentiation of bone cells in vitro." Thesis, University of St Andrews, 1990. http://hdl.handle.net/10023/14070.

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Osteoblastic differentiation was studied in vitro using primary cultures of bone cells derived from neonatal mouse calvaria. Using alkaline phosphatase as a marker, maintenance of the osteoblastic phenotype was found to be dependent upon the presence of ascorbic acid. No toxic effect due to ascorbic acid was seen. Insulin and dexamethasone were found to stimulate alkaline phosphatase expression, the former only in the absence of ascorbic acid. Two growth factors, epidermal growth factor and platelet-derived growth factor, were found to inhibit alkaline phosphatase expression in the presence of

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10

Weber, Matthew Charles. "Engineering human bone marrow stromal cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055867071.

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11

Ke, Jin, and 柯金. "Transgenic stem cells for craniofacial bone reconstruction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44362973.

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Bone loss from the cranio-maxillofacial region is a major clinical problem affecting patients worldwide. Conventional treatment strategy includes the use of autogenous or allogeneic bone, biomaterials, and osteogenic growth factors. However, there has been no effective therapy for most cases so far. Stem cell-based gene therapy is the latest research method with possible applications in humans. The present study aims to (1) characterize rabbit mesenchymal stem cells (MSCs) relating to growth pattern, surface antigens, and the potential for multi-differentiation; (2) determine the transduction

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12

Lloyd, Brandon R. "Comparison of Bone Marrow Mesenchymal Stem Cells from Limb and Jaw Bones." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1458678153.

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13

Both, Sanne Karijn. "Embryonic stem cells in bone tissue engineering." Enschede : University of Twente [Host], 2008. http://doc.utwente.nl/58765.

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14

O'Shaughnessy, Margaret Clare. "Nitric oxide mediated effects on bone cells." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367610.

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15

Amofah, Eunice. "Bone marrow stem cells in liver disease." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497234.

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16

Gu, Yuchun. "Investigation of ion channels on bone cells." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369360.

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17

Birch, Mark Andrew. "Investigations of bone cells in Paget's disease." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333632.

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18

Rawlinson, Simon Charles Fielding. "Early loading-related responses of bone cells." Thesis, Royal Veterinary College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313688.

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19

Hall, Brett Matthew. "Effects of high dose chemotherapy on the bone marrow microenvironment." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2558.

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Thesis (Ph. D.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains ix, 173 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 163-169).

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20

Kwong, Rebecca Sze-Wai. "Interaction of bone marrow-derived mesenchymal stem cells on neuroblastoma cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48541485.

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Background Mesenchymal stem cells (MSC) were first discovered in the 1970s by scientist A.J. Friedenstein and his colleagues. Friedenstein isolated the first mesenchymal stem cells and was credited for discovering its multilineage differentiation potential. To this day, an extensive amount of research has been conducted on the use of these cells in the treatment of degenerative diseases and various autoimmune disorders. Its migratory ability and immunosuppressive characteristics make MSCs advantageous in an inflammatory environment. Recently, MSCs were also found to have the ability to phago

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21

Tsui, Yat-ping, and 徐軼冰. "Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197485.

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Myelin is essential for neuronal survival and maintenance of normal functions of the nervous system. Demyelinating disorders are debilitating and are often associated with failure of resident oligodendrocyte precursor cells (OPCs) to differentiate into mature, myelinating oligodendrocytes. Derivation of OPCs, from a safe source that evades ethical issues offers a solution to remyelination therapy. We therefore hypothesized that bone marrow stromal cells (BMSCs) harbour neural progenitor cells at a pre-commitment stage and that in vitro conditions can be exploited to direct differentiation of t

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22

Raveney, Ben J. E. "Interactions between CD8+ T cells and bone marrow-derived dendritic cells." Thesis, University of Bristol, 2006. http://hdl.handle.net/1983/dbbc656f-a103-4787-aeb9-f203c3f0082b.

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23

Baba, Shinji. "Commitment of bone marrow cells to hepatic stellate cells in mouse." Kyoto University, 2005. http://hdl.handle.net/2433/144726.

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24

Bhattacharjee, Atanu. "The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair." Thesis, Keele University, 2018. http://eprints.keele.ac.uk/4592/.

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Aims: To evaluate the in vitro potential of umbilical cord(UC)-derived cells as an allogeneic cell source that could be used ‘off-the-shelf’ in orthopaedics for bone and cartilage regeneration. The study also assesses the in-vivo efficacy of cell therapy in orthopaedics for the formation of de novo bone, cartilage and integration of both. Methods: - In vitro potential of cells isolated from the four structural layers of the umbilical cord were characterised according to the criteria of the International Society for Cellular Therapy (ISCT). The differentiation potentials of these cell preparati

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25

Mauney, Joshua R. "Osteogenic differentiation of bone marrow stromal cells : implications to bone tissue engineering strategies /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.

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Thesis (Ph.D.)--Tufts University, 2004.<br>Adviser: David L. Kaplan. Submitted to the Dept. of Biotechnology Engineering. Includes bibliographical references (leaves 162-222). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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26

Adamek, Gaston. "Fatty acid oxidation in bone tissue and bone cells : characterization and hormonal influences /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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27

Singhatanadgit, Weerachai. "Expression and regulation of bone morphogenetic protein receptors in human alveolar bone cells." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445851/.

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Bone morphogenetic proteins (BMPs) are members of the transforming growth factor P (TGF-P) superfamily of growth factors that stimulate osteoblast differentiation and function. They exert their biological activities through signal transduction via three specific serine/threonine kinase transmembrane receptors, designated types-IA, -IB and -II (BMPR-IA, -IB and -II). These BMP-specific receptors thus determine in part the sensitivity and responsiveness of target cells to the BMP and thereby the biological activity of the BMP. However, little is known about BMPR-IA, -IB and -II in bone. The pres

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28

Aljazzar, Ahmed. "The role of osteocytes in the regulation of bone marrow mesenchymal stem cells." Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701677.

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29

Shah, Mittal. "The role of 5' adenosine monophosphate-activated protein kinase (AMPK) in bone physiology." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559073.

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30

Wang, Xiao Nong. "Quantitative analysis of alloreactive T cells in allogeneic stem cell transplantation." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362419.

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31

Liu, Limin. "Expression of follicular dendritic cell determinants by mouse bone marrow stromal cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ37142.pdf.

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32

Liu, Limin 1954. "Expression of follicular dendritic cell determinants by mouse bone marrow stromal cells." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27544.

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Stromal reticular cells in mouse bone marrow and follicular dendritic cells (FDC) in peripheral lymphoid tissues both interact with B lymphocytes and influence their development at various stages of the B cell lineage. The possibility that BM reticular cells and FDCs may share common surface properties has been examined in mouse bone marrow by in vivo administration of $ sp{125}$I-labelled purified monoclonal antibodies (mAb) raised against mouse FDC, detecting mAb-binding by light microscope (LM) and electron microscope (EM) radioautography. Young mice were injected intravenously with $ sp{12

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33

Nyambo, Rachel Netsai. "Signalling interactions between human bone marrow stromal cells and prostate cancer cells." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420799.

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34

Tang, Hoi-ching, and 鄧鎧政. "The developmental origin of osteoblasts in endochondral bone." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4659940X.

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35

Clutter, Suzanne Davis. "Chemotherapy disrupts bone marrow stromal cell function." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4528.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains x, 180 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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36

Zachos, Terri A. "Gene-augmented mesenchymal stem cells in bone repair." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1146076285.

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37

Ilvesaro, J. (Joanna). "Attachment, polarity and communication characteristics of bone cells." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514259351.

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Abstract Bone resorbing osteoclasts require tight attachment of their plasma membrane to the bone surface in order to retain the specific microenvironment and thus to be able to dissolve the bone matrix underneath. Cadherins are transmembrane glycoproteins usually mediating homophilic calcium-dependent cell-cell adhesion. In the present work we have studied the effects of the cadherin CAR sequence HAV-containing hexapeptide AHAVSE on osteoclasts. The primary attachment of osteoclasts to bone surface is not affected by the peptide, suggesting that it is not mediated by cadherins. Treatme

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38

Kapanen, A. (Anita). "Biocompatibility of orthopaedic implants on bone forming cells." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514266064.

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Abstract Reindeer antler was studied for its possible use as a bone implant material. A molecular biological study showed that antler contains a growth factor promoting bone formation. Ectopic bone formation assay showed that antler is not an equally effective inducer as allogenic material. Ectopic bone formation assay was optimised for biocompatibility studies of orthopaedic NiTi implants. Ti-6Al-4V and stainless steel were used as reference materials. The assay showed differences in bone mineral densities, with superior qualities in NiTi. The rate of endochondral ossification varie

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39

Randle, Wesley Liam. "Tissue engineering of bone from embryonic stem cells." Thesis, Imperial College London, 2006. http://hdl.handle.net/10044/1/11880.

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40

Al-Khaldi, Abdulaziz A. "Therapeutic angiogenesis using autologous bone marrow stromal cells." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32749.

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Objectives. To study marrow stromal cells (MSCs) induced angiogenesis. To examine the possible mechanisms involved in the process. To evaluate neovascularization following implantation of MSCs in ischemic hind limb model.<br>Methods and result. Using murine Matrigel angiogenesis model, we compared MSCs related angiogenesis to that produced by vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. We found that MSCs result in an efficient and organized angiogenesis, arteriogenesis and vasculogenesis. MSC-related angiogenesis is VEGF dependent. MSCs in vivo produce VEGF th

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41

Powell, Timothy Jack. "Characterisation of rat bone marrow derived dendritic cells." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298613.

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42

Graves, Stephen Ellis. "Studies on human bone-derived cells in vitro." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302849.

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43

El-Gendy, Reem Omar Othman Mostafa. "Bone tissue engineering using dental pulp stem cells." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535682.

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44

Rust, Philippa Ann. "Human mesenchymal stem cells for tissue engineering bone." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1383233/.

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My thesis hypothesises that cells isolated from human bone marrow could be stimulated to differentiate into osteoblasts and that, these cells when cultured on a scaffold could be used in the tissue engineering of bone, as the constructs could potentially be implanted into patients' bone defects resulting in increased healing. The multipotency of the bone marrow-isolated cells was assessed by the use of histological stains to show that they could be stimulated to differentiate into osteoblasts, chondrocytes and adipocytes. The cells were further characterised by Stro- 1 and, as a result, were d

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45

McDougall, Kathleen Emma. "Evaluation of biocompatibility using human craniofacial bone cells." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368260.

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46

Qualtrough, John David. "Bone morphogenetic proteins in human embryonal carcinoma cells." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311810.

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47

Matthews, Natalie Anne. "Functional characterisation of Notch signalling in bone cells." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442415.

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48

Spencer, Gary James. "Glutamate recycling and signalling mechanisms in bone cells." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399248.

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49

Marcotti, Stefania. "Mechanical characterisation of bone cells and their glycocalyx." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19596/.

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Mechanotransduction refers to the process by which a cell is able to translate mechanical stimulation into biochemical signals. In bone, mechanotransduction regulates how cells detect environmental stimuli and use these to direct towards bone deposition or resorption. The mechanical properties of bone cells have an impact on the way mechanical stimulation is sensed, however, little evidence is available about how these properties influence mechanotransduction. The aim of the present Thesis was to quantify the mechanical properties of bone cells with a combined experimental and computational ap

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50

Davies, Julie Theresa. "Activation of adhesion of bone marrow stromal cells." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656858.

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Osteoblasts, the bone-forming cells, derive from multipotential bone marrow stromal precursors called colony-forming units-fibroblastic (CFU-F). CFU-F rapidly adhere to plastic upon culture ex vivo, adhesion of such stromal precursors to bone in vivo is likely to be an early event in the anabolic response to bone stimulatory factors. It has been suggested that osteoclasts are involved in the activation of bone formation during bone remodelling. In order to test this, osteoclast conditioned medium was prepared from osteoclasts cultured on either plastic or bone. It was then used as culture medi

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