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Journal articles on the topic 'Bone-Implant Interactions'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Didier, Paul, Boris Piotrowski, Gael Le Coz, David Joseph, Pierre Bravetti, and Pascal Laheurte. "Finite Element Analysis of the Stress Field in Peri-Implant Bone: A Parametric Study of Influencing Parameters and Their Interactions for Multi-Objective Optimization." Applied Sciences 10, no. 17 (2020): 5973. http://dx.doi.org/10.3390/app10175973.

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The present work proposes a parametric finite element model of the general case of a single loaded dental implant. The objective is to estimate and quantify the main effects of several parameters on stress distribution and load transfer between a loaded dental implant and its surrounding bone. The interactions between them are particularly investigated. Seven parameters (implant design and material) were considered as input variables to build the parametric finite element model: the implant diameter, length, taper and angle of inclination, Young’s modulus, the thickness of the cortical bone an

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Prakash, Poonam, and Ambika Narayanan. "Biomechanics in dental implants." IP Annals of Prosthodontics and Restorative Dentistry 7, no. 3 (2021): 131–36. http://dx.doi.org/10.18231/j.aprd.2021.028.

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Achieving primary stability in dental implants is crucial factor for accomplishing successful osteointegration with bone. Micro-motions higher than the threshold of 50 to 100 μm can lead to formation of fibrous tissue at the bone-to-implant interface. Therefore, osteointegration may be vitiated due to insufficient primary stability. Osseointegration is defined as a direct and functional connection between the implant biomaterial and the surrounding bone tissue. Osseointegration development requires an initial rigid implant fixation into the bone at the time of surgery and a secondary stage of

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3

Będziński, R., J. Krzak-Roś, M. Stefańska, and K. Maruszewski. "Investigation of the Bone Tissue and Implant Surface Interactions." Strain 46, no. 6 (2010): 518–25. http://dx.doi.org/10.1111/j.1475-1305.2007.00383.x.

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4

Nascimento, Marvin do, Thays Obando Brito, Andreza Menezes Lima, and Carlos Nelson Elias. "Protein interactions with osseointegrable titanium implants." Brazilian Journal of Oral Sciences 22 (October 16, 2023): e238749. http://dx.doi.org/10.20396/bjos.v22i00.8668749.

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This review aims to present the mechanisms of protein interactions with titanium dental implant surfaces. Methods: the analyses were based on searches of scientific articles available in English and Portuguese in PubMed (MEDLINE), Bireme (LILACS), Scielo, Web of Science and Google Scholar. Results: titanium dental implant treatments success rates (95-98%) are mainly due to the biocompatibility of titanium oxide on the implant surface, surgical techniques adopted, good implants manufacturing processes and biomechanical knowledge of the systems. Studies in past decades has empirically developed

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Yun, Jong Il, Su In Yun, Jae Hong Kim, Duk Gyu Kim, and Deok-Won Lee. "Mediation of Osseointegration, Osteoimmunology, and Osteoimmunologic Integration by Tregs and Macrophages: A Narrative Review." International Journal of Molecular Sciences 26, no. 11 (2025): 5421. https://doi.org/10.3390/ijms26115421.

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Osseointegration is the direct contact between living bone and a dental implant, with supporting evidence confirming the direct connection between bone and titanium, found using an electron microscope. However, the fundamental mechanisms and interconnections between the bone and titanium are not clearly understood. At present, osteoimmunology explores the interaction between bone and immune cells not only in the medical field but also in dentistry. Immunology in bone cell formation has long been a research topic; however, interest in these effects has recently surged. Through subsequent studie

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Bishop, Nicholas E., Phil Wright, and Martin Preutenborbeck. "A parametric numerical analysis of femoral stem impaction." PLOS ONE 17, no. 5 (2022): e0268561. http://dx.doi.org/10.1371/journal.pone.0268561.

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Press-fitted implants are implanted by impaction to ensure adequate seating, but without overloading the components, the surgeon, or the patient. To understand this interrelationship a uniaxial discretised model of the hammer/introducer/implant/bone/soft-tissues was developed. A parametric analysis of applied energy, component materials and geometry, and interactions between implant and bone and between bone and soft-tissues was performed, with implant seating and component stresses as outcome variables. To reduce the impaction effort (energy) required by the surgeon for implant seating and al

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Cavalu, Simona, Viorica Simon, Cristian Ratiu, Ioan George Oswald, Vlad Silviu, and Oana Ponta. "Alternative Approaches Using Animal Model for Implant Biomaterials: Advantages and Disadvantages." Key Engineering Materials 583 (September 2013): 101–6. http://dx.doi.org/10.4028/www.scientific.net/kem.583.101.

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This study presents some aspects regarding the evaluation of bone-implant interactions using two animal models (rabbit and rat). The proposed implants are new alumina/zirconia bioceramics designed for hard tissue replacement (oral implantology or arthroplasty). The animal selection was made based on the number and size or design of implants to be tested as these factors influence directly the species of animal chosen for this study. The correct placement and stability of the implants were evaluated by radiographic images. SEM micrographs were recorded on the bone/implant area along with the el

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Zain, M. N. A., R. Daud, M. M. S. Azmi, and M. N. F. Noor. "Stress shielding and amplification in alveolar cortical-cancellous bone fractures: An analysis of implant-bone stress interactions." Mathematical Modeling and Computing 12, no. 2 (2025): 498–511. https://doi.org/10.23939/mmc2025.02.498.

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The effectiveness of dental implants greatly relies on the attainment of osseointegration and the sustained stability of the implant in the long run. An essential factor in achieving this success lies in comprehending the shift from primary to secondary stability and the consequences of microcracks that occur during the drilling of alveolar bone before implantation. The objective of this study is to examine the stress interactions occurring in double-edge parallel cracks within heterogeneous (cortical-cancellous) bone under different loading conditions, particularly mode I, mode II, and mixed-

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Sonnenburg, Robert E., Phillip A. Wackym, Narayan Yoganandan, Jill B. Firszt, Robert W. Prost, and Frank A. Pintar. "Biophysics of Cochlear Implant/MRI Interactions Emphasizing Bone Biomechanical Properties." Laryngoscope 112, no. 10 (2002): 1720–25. http://dx.doi.org/10.1097/00005537-200210000-00002.

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10

Rostamzadeh, Sajjad, Mohammad Ghasemirad, Mohammad Gerayeli, et al. "Radiographic Evaluation of Implant Stability and Osseointegration in Adult Orthodontic Patients." Galen Medical Journal 14 (April 18, 2025): e3799. https://doi.org/10.31661/gmj.v14i.3799.

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Radiographic evaluation is essential for assessing implant stability and osseointegration in adult orthodontic patients. The success of temporary anchorage devices (TADs) and mini-implants depends on primary stability, achieved through mechanical engagement, and secondary stability, influenced by bone remodeling. While traditional clinical methods, such as mobility testing, provide subjective assessments, radiographic imaging offers objective insights into bone-implant interactions. Periapical and panoramic radiographs are commonly used but are limited by their two-dimensional (2D) nature. Con

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Lavenus, Sandrine, Guy Louarn, and Pierre Layrolle. "Nanotechnology and Dental Implants." International Journal of Biomaterials 2010 (2010): 1–9. http://dx.doi.org/10.1155/2010/915327.

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The long-term clinical success of dental implants is related to their early osseointegration. This paper reviews the different steps of the interactions between biological fluids, cells, tissues, and surfaces of implants. Immediately following implantation, implants are in contact with proteins and platelets from blood. The differentiation of mesenchymal stem cells will then condition the peri-implant tissue healing. Direct bone-to-implant contact is desired for a biomechanical anchoring of implants to bone rather than fibrous tissue encapsulation. Surfaces properties such as chemistry and rou

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Ihde, Stefan, Antonina Ihde, Olga Sipic, and Łukasz Pałka. "Peri-Implantitis: A New Definition Proposal Based on Unnatural Spatial Arrangement and Late Mechanical Coupling between Two Cortical Bone Layers during Osseointegration Phase Part II." Applied Sciences 12, no. 11 (2022): 5589. http://dx.doi.org/10.3390/app12115589.

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To date, the term peri-implantitis has been mostly associated with bacterial or foreign body reaction as primary factors of its development. Because of this, researchers’ and clinicians’ attention regarding treatment possibilities were directed into the solutions on the basis of surface modifications, debridement, and antibiotics. After years of clinical observations and poor results in treatment of peri-implantitis, a new proposal of this condition is presented, shifting our way of thinking regarding bone and implant interactions. In the second part of the paper presenting a new definition of

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13

Kim, Jun-Sik, Jae-Pyeong Ahn, Yang-Hee Kim, Kyung Won Seo, Homayoun Zadeh, and Seong-Hun Kim. "Atomic layout of an orthodontic titanium mini-implant in human tissue: Insights into the possible mechanisms during osseointegration." Angle Orthodontist 89, no. 2 (2018): 292–98. http://dx.doi.org/10.2319/051418-354.1.

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ABSTRACT Objectives: To evaluate nanoscale molecular interactions in the interface between human bone and orthodontic titanium implants. Materials and Methods: An orthodontic implant (sandblasted with large grit and with an acid-etched surface treated with Ti6A14V alloy) retrieved from the mandible of human after 2 months of healing was used to analyze the molecular interactive mechanism between the implant and the surrounding bone tissue. To preserve the natural state of the sample as much as possible, cryofixation and scanning electron microscope/focused ion beam milling without any chemical

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Ballini, Andrea, Apollonia Desiate, and Stefania Cantore. "In vitro Comparison between Two Different Implant Titanium Surfaces in Osseointegration Process." International Journal of Experimental Dental Science 1, no. 2 (2012): 84–88. http://dx.doi.org/10.5005/jp-journals-10029-1021.

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ABSTRACT The osseointegration rate of titanium dental implants is related to their composition and surface roughness. Rough-surfaced implants favor both bone anchoring and biomechanical stability. The future of dental implantology should aim to develop surfaces with controlled and standardized topography or chemistry. This approach will be the only way to understand the interactions between proteins, cells and tissues and implant surfaces. The local release of bone stimulating or resorptive drugs in the peri-implant region may also respond to difficult clinical situations with poor bone qualit

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15

Madani, Khairiah Adel, Abdulaziz Abduallah Alljarallah, Faten Abdullah Alnasser, Mnhal Khalid Alfuraih, Abdullah Hamad Al-Mutairi, and Raed Mohammed Barayan. "Biomechanics in Implant Prosthodontics: Principles for Optimal Design and Function." JOURNAL OF HEALTHCARE SCIENCES 04, no. 12 (2024): 697–704. https://doi.org/10.52533/johs.2024.41209.

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Recent advancements in dental implantology have significantly transformed the field, accommodating both clinicians' aesthetic demands and rising patient expectations. Various implant designs now exist, differing in shape, surface, and size, requiring clinicians to meticulously evaluate each option based on biomechanical principles tailored to individual patient anatomy. Biomechanics, which examines mechanical principles in relation to biological issues, is essential for the success of dental implants. It involves the transfer of loads from the implant to surrounding bone tissues, requiring a d

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Elias, Carlos Nelson, Késia Simões Ribeiro, Patrick de Lima Gomes, Marvin do Nascimento, and Bruno Martins de Souza. "Osseointegration, inflammatory process and foreign body reaction of dental titanium implants." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22, no. 12 (2024): e8087. https://doi.org/10.55905/oelv22n12-047.

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There has yet to be a consensus among researchers, professionals, companies, regulatory agencies, and technical standards regarding the definition of osseointegration. The divergence is conceptual and occurs due to explanations of the mechanisms of interactions among cells and proteins with the implant. In medicine, osseointegration is assessed visually in radiographic examinations by the absence of implant-bone space or by mechanical stability and absence of pain. In the medical field, it is mentioned that there is osseointegration of cemented orthopedic prostheses, stainless steel prostheses

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17

Bizios, Rena. "Mini-review: Osteoblasts: An in vitro model of bone-implant interactions." Biotechnology and Bioengineering 43, no. 7 (1994): 582–85. http://dx.doi.org/10.1002/bit.260430707.

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Brochado, Ana Carolina Batista, Victor Hugo de Souza, Joice Correa, et al. "Osteosphere Model to Evaluate Cell–Surface Interactions of Implantable Biomaterials." Materials 14, no. 19 (2021): 5858. http://dx.doi.org/10.3390/ma14195858.

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Successful biomaterials for bone tissue therapy must present different biocompatible properties, such as the ability to stimulate the migration and proliferation of osteogenic cells on the implantable surface, to increase attachment and avoid the risks of implant movement after surgery. The present work investigates the applicability of a three-dimensional (3D) model of bone cells (osteospheres) in the evaluation of osteoconductive properties of different implant surfaces. Three different titanium surface treatments were tested: machined (MA), sandblasting and acid etching (BE), and Hydroxyapa

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19

Harikumar, Girish, T. Aby Mathew, Riya Sabu, and Merin Basil. "Management of Completely Edentulous Patients with Atrophic Bone Using Implant Therapy: Current Trends and Future Perspectives." Kerala Dental Journal 48, no. 2 (2025): 59–68. https://doi.org/10.4103/ksdj.ksdj_42_24.

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Abstract Edentulism, the complete loss of all teeth, is a global issue affecting individuals’ physical and psychological well-being. It results from various biological factors like dental diseases and social factors such as limited oral care and education access. The absence of teeth affects aesthetics, speech and overall comfort, impacting the quality of life negatively. Traditional complete removable dentures, though widely used, come with limitations. They fail to stimulate jawbones, leading to bone loss and loose dentures. Stability issues arise with severely resorbed ridges and inadequate

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Frandsen, Christine J., Karla S. Brammer, and Sungho Jin. "Variations to the Nanotube Surface for Bone Regeneration." International Journal of Biomaterials 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/513680.

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The complex mechanisms of the bone cell-surface interactions are yet to be completely understood, and researchers continue to strive to uncover the fully optimized implant material for perfect osseointegration. A particularly fascinating area of research involves the study of nanostructured surfaces, which are believed to enhance osteogenic behavior, possibly due to the mimicry of components of the extracellular matrix of bone. There is a growing body of data that emphasizes the promise of the titanium oxide (TiO2) nanotube architecture as an advanced orthopedic implant material. The review he

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Quintero, David G., Julia N. Winger, Rania Khashaba, and James L. Borke. "Advanced Glycation Endproducts and Rat Dental Implant Osseointegration." Journal of Oral Implantology 36, no. 2 (2010): 97–103. http://dx.doi.org/10.1563/aaid-joi-d-09-00032.

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Abstract Advanced glycation endproducts (AGEs) are a diverse group of molecular adducts formed in environments high in reducing sugars that accumulate with aging and in diabetes. This study tests the hypothesis that AGEs inhibit the stabile osseointegration of dental implants through tissue interactions that interfere with bone turnover and compromise the biomechanical properties at the bone-implant interface. Maxillary first molars were extracted from 32 rats and allowed to heal for 4 weeks. Titanium implants (1 mm × 3 mm) were placed in the healed sockets of 2 groups of 16 rats consisting of

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Christophy, C., N. Rashid, Lucy DiSilvio, and Karen A. Hing. "Encouraging Nature with Ceramics: The Roles of Surface Roughness and Physio-Chemistry on Cell Response to Substituted Apatites." Advances in Science and Technology 57 (September 2008): 22–30. http://dx.doi.org/10.4028/www.scientific.net/ast.57.22.

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The success or failure of a bioactive ceramic implant material in the body depends on a complex interaction between a synthetic foreign body and the host. These interactions occur at many levels from the nano-structural level, where subtle changes in surface physio-chemistry substantially alters the nature of the biomaterial-host tissue interface, to the meso- or macrostructural level where dependence on porosity mediates bioactivity through its effect on nutrient transfer and scaffold mechanics. Thus the factors that control the biological response to implant materials are a complex combinati

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Vadivelmurugan, Adhisankar, and Shiao-Wen Tsai. "The Influence of Scaffold Interfaces Containing Natural Bone Elements on Bone Tissue Engineering Applications." Coatings 12, no. 12 (2022): 1888. http://dx.doi.org/10.3390/coatings12121888.

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Bone has the capacity to repair damage and reproduce itself, but if the defect is too large, a scaffold is needed to promote regeneration. Recently, researchers have developed numerous approaches to promote bone reformation, such as the direct delivery of bioactive molecules, guided tissue regeneration membranes, and creating osteoinduction/osteoconduction surfaces. The surface of a medical device is the first contact area for a biological system; therefore, the interactions between biological fluids and the surface of the implant determine the performance of the implant. Well-designed surface

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Dotta, Tatiane Cristina, Simonetta D’Ercole, Giovanna Iezzi, Vinicius Pedrazzi, Rodrigo Galo, and Morena Petrini. "The Interaction between Oral Bacteria and 3D Titanium Porous Surfaces Produced by Selective Laser Melting—A Narrative Review." Biomimetics 9, no. 8 (2024): 461. http://dx.doi.org/10.3390/biomimetics9080461.

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The interaction between oral bacteria and dental implant surfaces is a critical factor in the success and longevity of dental implants. With advancements in additive manufacturing technologies, selective laser melting (SLM) has emerged as a prominent method for producing titanium implants with highly controlled microstructures and porosities. These 3D printed titanium surfaces offer significant benefits, such as enhanced osseointegration and improved mechanical properties. However, the same surface features that promote bone cell attachment and proliferation may also provide favorable conditio

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Petrović, Željka, Ankica Šarić, Ines Despotović, et al. "A New Insight into Coating’s Formation Mechanism Between TiO2 and Alendronate on Titanium Dental Implant." Materials 13, no. 14 (2020): 3220. http://dx.doi.org/10.3390/ma13143220.

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Organophosphorus compounds, like bisphosphonates, drugs for treatment and prevention of bone diseases, have been successfully applied in recent years as bioactive and osseoinductive coatings on dental implants. An integrated experimental-theoretical approach was utilized in this study to clarify the mechanism of bisphosphonate-based coating formation on dental implant surfaces. Experimental validation of the alendronate coating formation on the titanium dental implant surface was carried out by X-ray photoelectron spectroscopy and contact angle measurements. Detailed theoretical simulations of

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Abouel Nasr, Emad, Abdurahman Mushabab Al-Ahmari, Khaja Moiduddin, Mohammed Al Kindi, and Ali K. Kamrani. "A digital design methodology for surgical planning and fabrication of customized mandible implants." Rapid Prototyping Journal 23, no. 1 (2017): 101–9. http://dx.doi.org/10.1108/rpj-11-2014-0157.

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Purpose The purpose of this paper is to demonstrate the route to digitize the customized mandible implants consisting of image acquisition, processing, implant design, fitting rehearsal and fabrication using fused deposition modeling and electron beam melting methodologies. Design/methodology/approach Recent advances in the field of rapid prototyping, reverse engineering, medical imaging and image processing have led to new heights in the medical applications of additive manufacturing (AM). AM has gained a lot of attention and interest during recent years because of its high potential in medic

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Jäger, Marcus, Agnieszka Latosinska, Monika Herten, André Busch, Thomas Grupp, and Andrea Sowislok. "The Implant Proteome—The Right Surgical Glue to Fix Titanium Implants In Situ." Journal of Functional Biomaterials 13, no. 2 (2022): 44. http://dx.doi.org/10.3390/jfb13020044.

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Titanium implants are frequently applied to the bone in orthopedic and trauma surgery. Although these biomaterials are characterized by excellent implant survivorship and clinical outcomes, there are almost no data available on the initial protein layer binding to the implant surface in situ. This study aims to investigate the composition of the initial protein layer on endoprosthetic surfaces as a key initiating step in osseointegration. In patients qualified for total hip arthroplasty, the implants are inserted into the femoral canal, fixed and subsequently explanted after 2 and 5 min. The p

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Anitua, Eduardo, and Ricardo Tejero. "Provisional Matrix Formation at Implant Surfaces—The Bridging Role of Calcium Ions." Cells 11, no. 19 (2022): 3048. http://dx.doi.org/10.3390/cells11193048.

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The success of dental implants lies in their strong and lasting integration into the patient’s receiving bone. The first biological interactions at the implant surface determine the subsequent evolution of the integration process. In this study we set our objective to analyze the mechanistic interaction of the early regenerative matrix at implant surfaces modified with calcium ions (Ca) as compared to standard implant surfaces (NoCa). We put the surfaces in a Quartz Crystal Microbalance with Dissipation (QCM-D) to monitor the frequency shift (f) and the viscoelastic properties of the adsorbed

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Lewis, Kanthi, S. M. Valenzuela, and Besim Ben-Nissan. "Changes in the Activity of Osteoblast Like Cells with Sol-Gel Derived Hydroxyapatite and Zirconia Nanocoatings." Key Engineering Materials 361-363 (November 2007): 633–36. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.633.

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When producing implant materials, achievement of optimal bioactivity and biocompatibility are essential. Nanocoatings can provide an efficient cost effective way to alter the interactions of the implant material with its destined “host” environment. Nanocoatings of sol-gel derived carbonated hydroxyapatite (HAp) and zirconia were produced in this study. The surfaces were characterised by Fourier transform infrared spectroscopy (FTIR) and light microscopy. Cell adhesion, proliferation and viability, as well as expression of alkaline phosphatase (ALP is an indicator of bone formation) were asses

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Sisti, Karin E., María C. de Andrés, David Johnston, Edson Almeida-Filho, Antonio C. Guastaldi, and Richard O. C. Oreffo. "Skeletal stem cell and bone implant interactions are enhanced by LASER titanium modification." Biochemical and Biophysical Research Communications 473, no. 3 (2016): 719–25. http://dx.doi.org/10.1016/j.bbrc.2015.10.013.

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Mešić, Elmedin, Enis Muratović, Lejla Redžepagić-Vražalica, et al. "Experimental & FEM Analysis of Orthodontic Mini-Implant Design on Primary Stability." Applied Sciences 11, no. 12 (2021): 5461. http://dx.doi.org/10.3390/app11125461.

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The main objective of this research is to establish a connection between orthodontic mini-implant design, pull-out force and primary stability by comparing two commercial mini-implants or temporary anchorage devices, Tomas®-pin and Perfect Anchor. Mini-implant geometric analysis and quantification of bone characteristics are performed, whereupon experimental in vitro pull-out test is conducted. With the use of the CATIA (Computer Aided Three-dimensional Interactive Application) CAD (Computer Aided Design)/CAM (Computer Aided Manufacturing)/CAE (Computer Aided Engineering) system, 3D (Three-dim

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Watazu, Akira, Kay Teraoka, Hirofumi Kido, et al. "Formation of Titanium Oxide/Titanium/Plastic Composites." Key Engineering Materials 361-363 (November 2007): 487–90. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.487.

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Titanium oxide/ titanium/ plastic composite implants were formed by coating commercially pure titanium thin films on the surfaces of plastic cylinders by DC magnetron sputtering method. The composite is uniformly formed and the surface of the composite implant is smooth. The implants in rat tibias were not broken and the films on the surfaces of the samples did not decompose. The samples with bone were able to cut by diamond knife and observations between bone and titanium oxide on titanium by TEM succeeded. Therefore, the composite is useful for implants or observations the interactions betwe

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Kieswetter, K., Z. Schwartz, D. D. Dean, and B. D. Boyan. "The Role of Implant Surface Characteristics in the Healing of Bone." Critical Reviews in Oral Biology & Medicine 7, no. 4 (1996): 329–45. http://dx.doi.org/10.1177/10454411960070040301.

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The surface of an implant determines its ultimate ability to integrate into the surrounding tissue. The composite effect of surface energy, composition, roughness, and topography plays a major role during the initial phases of the biological response to the implant, such as protein adsorption and cellular adherence, as well as during the later and more chronic phases of the response. For bone, the successful incorporation (and hence rigid fixation) of an alloplastic material within the surrounding bony bed is called osteointegration. The exact surface characteristics necessary for optimal oste

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Carradò, Adele. "Development of Bioactive Hydroxyapatite Coatings on Titanium Alloys." Key Engineering Materials 533 (December 2012): 183–93. http://dx.doi.org/10.4028/www.scientific.net/kem.533.183.

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Bioactive coatings are currently manufacturing using plasma-sprayed technique on metal implant surfaces in order to optimize bone-implant interactions. Nevertheless, some problems exist with coating process, e.g. poor interfacial adhesion, modification of coating properties, and the lack of an existing coating standard. In order to overcome some of the problems with the plasma-spraying process, researchers are investigating other experimental coating methods to enhance the adhesion and to control the coating properties. This paper will discuss the advantages and disadvantages of plasma sprayin

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Kim, Hongdeok, Byeonghwa Goh, Sol Lee, Kyujo Lee, and Joonmyung Choi. "Computational Study on Interfacial Interactions between Polymethyl Methacrylate-Based Bone Cement and Hydroxyapatite in Nanoscale." Applied Sciences 11, no. 7 (2021): 2937. http://dx.doi.org/10.3390/app11072937.

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Polymethyl methacrylate (PMMA)-based bone cement (BC) is a key material in joint replacement surgery that transfers external forces from the implant to the bone while allowing their robust binding. To quantitatively evaluate the effect of polymerization on the thermomechanical properties of the BC and on the interaction characteristics with the bone ceramic hydroxyapatite (HAp), molecular dynamics simulations were performed. The mechanical stiffness of the BC material under external loading increased gradually with the crosslinking reaction occurrence, indicating increasing load transfer betwe

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Kaushik, Neha, Linh Nhat Nguyen, June Hyun Kim, Eun Ha Choi, and Nagendra Kumar Kaushik. "Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering." International Journal of Molecular Sciences 21, no. 18 (2020): 6544. http://dx.doi.org/10.3390/ijms21186544.

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In the field of tissue engineering, there are several issues to consider when designing biomaterials for implants, including cellular interaction, good biocompatibility, and biochemical activity. Biomimetic mineralization has gained considerable attention as an emerging approach for the synthesis of biocompatible materials with complex shapes, categorized organization, controlled shape, and size in aqueous environments. Understanding biomineralization strategies could enhance opportunities for novel biomimetic mineralization approaches. In this regard, mussel-inspired biomaterials have recentl

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Staruch, RMT, MF Griffin, and PEM Butler. "Nanoscale Surface Modifications of Orthopaedic Implants: State of the Art and Perspectives." Open Orthopaedics Journal 10, no. 1 (2016): 920–38. http://dx.doi.org/10.2174/1874325001610010920.

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Background:Orthopaedic implants such as the total hip or total knee replacement are examples of surgical interventions with postoperative success rates of over 90% at 10 years. Implant failure is associated with wear particles and pain that requires surgical revision. Improving the implant - bone surface interface is a key area for biomaterial research for future clinical applications. Current implants utilise mechanical, chemical or physical methods for surface modification.Methods:A review of all literature concerning the nanoscale surface modification of orthopaedic implant technology was c

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Suárez-Franco, José Luis, Manuel García-Hipólito, Miguel Ángel Surárez-Rosales, et al. "Effects of Surface Morphology ofZnAl2O4Ceramic Materials on Osteoblastic Cells Responses." Journal of Nanomaterials 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/361249.

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Ceramic scaffolds are widely studied in the tissue engineering field due to their potential in medical applications as bone substitutes or as bone-filling materials. The purpose of this study was to investigate the effect of surface morphology of nanostructure thin films of ZnAl2O4prepared by spray pyrolysis and bulk pellets of polycrystalline ZnAl2O4prepared by chemical coprecipitation reaction on thein vitrocell adhesion, viability, and cell-material interactions of osteoblastic cells. Our result showed that cell attachment was significantly enhanced from 60 to 80% on the ZnAl2O4nanostructur

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Ng, Ethan, John Rong Hao Tay, Nikos Mattheos, Nagihan Bostanci, Georgios N. Belibasakis, and Chaminda Jayampath Seneviratne. "A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis." Cells 13, no. 4 (2024): 315. http://dx.doi.org/10.3390/cells13040315.

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This mapping review highlights the need for a new paradigm in the understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on the relationship between biofilm, inflammation, and bone biology. The close interactions between immune and bone cells are discussed, with multiple stable states likely existing between clinically observable definitions of peri-implant health and peri-implantitis. The framework presented aims to explain the transition from health to disease as a staged and incremental process, where

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Pedowitz, David I., Ezequiel Palmanovich, and Meir Nyska. "Finite Element Analysis for First Metatarsophalangeal Joint Arthrodesis Demonstrates Reduction in Stress Across Bio-Integrative Fixation Over Traditional Metal Fixation." Foot & Ankle Orthopaedics 7, no. 4 (2022): 2473011421S0087. http://dx.doi.org/10.1177/2473011421s00876.

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Category: Midfoot/Forefoot; Bunion Introduction/Purpose: During each step-in gait, the first metatarsophalangeal joint (MTPJ) is stressed by 90% of body weight, while loading the metatarsal head and base with up to 29% (228N/80Kg patient) of body weight (188N) during each foot push-off. To withstand these high mechanical forces, a successful fusion is dependent on joint preparation and rigid fixation. In this study we assessed a novel bio-integrative fiber-reinforced screw and nail construct. This material technology may provide improved mechanical fixation profile through its high flexural st

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Ungvári, Krisztina, Sándor Mészáros, Anna Szabó, Klára Hernádi, and Zsolt Tóth. "In Vitro Biocompatibility Test of Multiwall Carbon Nanotubes with Human Osteoblast Cells: Potential Application for Bone Implant Interface Reinforcement." Journal of Nanoscience and Nanotechnology 21, no. 4 (2021): 2394–403. http://dx.doi.org/10.1166/jnn.2021.18966.

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Application of multiwall carbon nanotubes (MWCNT) as a filler component in composite materials can lead to remarkable increase in mechanical strength. It is a challenging application to form a living bone tissue biocomposite that is reinforced with MWCNTs at a dental implant—bone interface. The successful biointegration of MWCNT and the implant material depends on the processes of osseointegration, namely surface interactions at the molecular and cellular level. In this work the compatibility of MWCNT with main osseointegration processes has been overviewed with special attention to the toxici

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Despotović, Ines, Željka Petrović, Jozefina Katić, and Dajana Mikić. "Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP–Alendronate Interactions." Materials 17, no. 11 (2024): 2703. http://dx.doi.org/10.3390/ma17112703.

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The surface modification of dental implants plays an important role in establishing a successful interaction of the implant with the surrounding tissue, as the bioactivity and osseointegration properties are strongly dependent on the physicochemical properties of the implant surface. A surface coating with bioactive molecules that stimulate the formation of a mineral calcium phosphate (CaP) layer has a positive effect on the bone bonding process, as biomineralization is crucial for improving the osseointegration process and rapid bone ingrowth. In this work, the spontaneous deposition of calci

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Webster, Thomas J. "Nanotechnology: Better Materials for All Implants." Materials Science Forum 539-543 (March 2007): 511–16. http://dx.doi.org/10.4028/www.scientific.net/msf.539-543.511.

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Nanotechnology is being used to mimic structural components of our tissues in synthetic materials intended for various implant applications. Recent studies have highlighted that when compared to flat or micron rough surfaces, surfaces with nanofeatures promote optimal initial protein interactions necessary to mediate cell adhesion and subsequent tissue regrowth. This has been demonstrated for a wide range of implant chemistries (from ceramics to metals to polymers) and for a wide range of tissues (including bone, vascular, cartilage, bladder, and the central and peripheral nervous system). Imp

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Al-Harbi, Nuha, Hiba Mohammed, Yas Al-Hadeethi, et al. "Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review." Pharmaceuticals 14, no. 2 (2021): 75. http://dx.doi.org/10.3390/ph14020075.

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Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue–implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dio

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Iacono, Roberta, Yaniv Mayer, Gaetano Marenzi, et al. "Clinical, Radiological, and Aesthetic Outcomes after Placement of a Bioactive-Surfaced Implant with Immediate or Delayed Loading in the Anterior Maxilla: 1-Year Retrospective Follow-Up Study." Prosthesis 5, no. 3 (2023): 610–21. http://dx.doi.org/10.3390/prosthesis5030043.

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Background: Dental implants have become the standard for replacing missing teeth. However, patients’ demands for shorter treatment times and the desire for aesthetics in their results can complicate the rehabilitation process, particularly when poor-quality bone is involved. In order to address these challenges, new methods of treating implant surfaces have been introduced. These methods aim to make the implants superhydrophilic and bioactive, enhancing their functionality and interactions with the surrounding tissues. Aim: The aim of the study was to retrospectively examine the efficacy of a

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Pacelli, Settimio, Vijayan Manoharan, Anna Desalvo, et al. "Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy." Journal of Materials Chemistry B 4, no. 9 (2016): 1586–99. http://dx.doi.org/10.1039/c5tb01686j.

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Eisa Aldabeab, Khalid, and Asim Alsuwaiyan. "The Impact of Systemic Drug Therapies (Bisphosphonates and Immunosuppressants) on Dental Implant Success: A clinical review." Galen Medical Journal 13, SP1 (2024): e3666. https://doi.org/10.31661/gmj.v13isp1.3666.

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Under normal physiological conditions, dental implants are a reliable and effective choice for tooth replacement with high success rates. However, compromised implant success is more closely related to systemic drug therapies like bisphosphonates and immunosuppressants used in patients. This review aims to identify key patterns of implant success and complications among patients undergoing long-term systemic drug therapy and provide clinical recommendations for optimizing outcomes. Bisphosphonates, especially in their intravenous (IV) forms, inhibit osteoclast activity and decrease bone turnov

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Zhu, Haochen, Xinyi Xia, Chao-Ching Chiang, et al. "Osteoblast Growth in Quaternized Silicon Carbon Nitride Coatings for Dental Implants." Materials 17, no. 21 (2024): 5392. http://dx.doi.org/10.3390/ma17215392.

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The demand for dental implants has increased, establishing them as the standard of care for replacing missing teeth. Several factors contribute to the success or failure of an implant post-placement. Modifications to implant surfaces can enhance the biological interactions between bone cells and the implant, promoting better outcomes. Surface coatings have been developed to electrochemically alter implant surfaces, aiming to reduce healing time, enhance bone growth, and prevent bacterial adhesion. Quaternized silicon carbon nitride (QSiCN) is a novel material with unique electrochemical and bi

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Aryee, Ken-Edwin, Michael A. Brehm, Leonard D. Shultz, and Agata Jurczyk. "Modeling immune system-tumor interactions using humanized mice." Journal of Immunology 196, no. 1_Supplement (2016): 212.12. http://dx.doi.org/10.4049/jimmunol.196.supp.212.12.

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Abstract The interplay between tumor cells, the non-malignant stoma and hematolymphoid cells (of both innate and adoptive lineages) determines the kinetics of cancer progression. However, the study of tumor-immune system interactions has primarily been restricted to mouse models. The implant of tumors into humanized mice that are engrafted with human immune systems provides a unique opportunity to interrogate the interactions between human immune cells and malignancies, and to test novel anti-tumor immunotherapies. Here we show the use of the BLT (bone marrow/liver/thymus) humanized mouse mode

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Petrović, Željka, Ankica Šarić, Ines Despotović, et al. "Surface Functionalisation of Dental Implants with a Composite Coating of Alendronate and Hydrolysed Collagen: DFT and EIS Studies." Materials 15, no. 15 (2022): 5127. http://dx.doi.org/10.3390/ma15155127.

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The success of the osseointegration process depends on the surface characteristics and chemical composition of dental implants. Therefore, the titanium dental implant was functionalised with a composite coating of alendronate and hydrolysed collagen, which are molecules with a positive influence on the bone formation. The results of the quantum chemical calculations at the density functional theory level confirm a spontaneous formation of the composite coating on the titanium implant, ∆G*INT = −8.25 kcal mol−1. The combination of the results of X-ray photoelectron spectroscopy and quantum chem

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