Relevant bibliographies by topics / Bone marrow adipocytes

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Bone marrow adipocytes'

Author: Grafiati
Published: 1 February 2025
Last updated: 31 July 2025

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Journal articles on the topic "Bone marrow adipocytes"

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Naveiras, Olaia, Valentina Nardi, and George Q. Daley. "Bone Marrow Adipocytes Prevent Hematopoietic Expansion in Homeostasis and in Bone Marrow Transplantation." Blood 112, no. 11 (2008): 551. http://dx.doi.org/10.1182/blood.v112.11.551.551.

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Abstract In mammalian bone marrow (BM), osteoblasts and endothelium constitute functional niches that support hematopoietic stem cells (HSC). Adult BM also contains numerous adipocytes, whose numbers correlate inversely with the hematopoietic activity of the marrow. As described by Neumann’s law in 1882, distal skeletal regions are adipocytic and thus non-hematopoietic in the adult. Fatty infiltration of the hematopoietic red marrow also occurs following irradiation or chemotherapy and is a diagnostic feature in biopsies from patients with marrow aplasia. However, whether adipocytes participat
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Yang, S., W. Lu, C. Zhao, et al. "PF457 MECHANISM OF MORPHOLOGICAL REMODELING OF BONE MARROW ADIPOCYTES IN ACUTE MYELOID LEUKEMIA." HemaSphere 3, S1 (2019): 180. http://dx.doi.org/10.1002/j.2572-9241.2019.tb00056.x.

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Background:We have previously found that morphological remodeling of bone marrow adipocytes in acute myeloid leukemia (AML) patients is closely related to poor prognosis, and growth differentiation factor 15 (GDF15) may be a key factor in this pathological phenomenon.Aims:In this study, we further explored the mechanism of GDF15 regulating the bone marrow adipocyte remodeling from the perspective of calcium channel TRPV4.Methods:GDF15‐induced adipocytes were analyzed using gene expression profiling, and gene knockdown cells were generated by lentiviral‐mediated shRNA. Chip‐qPCR was used to eva
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Kwak, Jun-Goo, and Jungwoo Lee. "Bone Marrow Adipocytes Contribute to Tumor Microenvironment-Driven Chemoresistance via Sequestration of Doxorubicin." Cancers 15, no. 10 (2023): 2737. http://dx.doi.org/10.3390/cancers15102737.

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Chemoresistance is a significant problem in the effective treatment of bone metastasis. Adipocytes are a major stromal cell type in the bone marrow and may play a crucial role in developing microenvironment-driven chemoresistance. However, detailed investigation remains challenging due to the anatomical inaccessibility and intrinsic tissue complexity of the bone marrow microenvironment. In this study, we developed 2D and 3D in vitro models of bone marrow adipocytes to examine the mechanisms underlying adipocyte-induced chemoresistance. We first established a protocol for the rapid and robust d
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Lecka-Czernik, Beata, та Larry J. Suva. "Resolving the Two “Bony” Faces of PPAR-γ". PPAR Research 2006 (2006): 1–9. http://dx.doi.org/10.1155/ppar/2006/27489.

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Bone loss with aging results from attenuated and unbalanced bone turnover that has been associated with a decreased number of bone forming osteoblasts, an increased number of bone resorbing osteoclasts, and an increased number of adipocytes (fat cells) in the bone marrow. Osteoblasts and adipocytes are derived from marrow mesenchymal stroma/stem cells (MSC). The milieu of intracellular and extracellular signals that controls MSC lineage allocation is diverse. The adipocyte-specific transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) acts as a critical positive regula
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Liu, Huan, Jin He, Su Pin Koh, et al. "Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease." Science Translational Medicine 11, no. 494 (2019): eaau9087. http://dx.doi.org/10.1126/scitranslmed.aau9087.

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Osteolytic lesions in multiple myeloma are caused by osteoclast-mediated bone resorption and reduced bone formation. A unique feature of myeloma is a failure of bone healing after successful treatment. We observed adipocytes on trabecular bone near the resorbed area in successfully treated patients. Normal marrow adipocytes, when cocultured with myeloma cells, were reprogrammed and produced adipokines that activate osteoclastogenesis and suppress osteoblastogenesis. These adipocytes have reduced expression of peroxisome proliferator–activated receptor γ (PPARγ) mediated by recruitment of polyc
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Jin, Linhua, Marina Konopleva, Yixin Zhou, et al. "Pro-Apoptotic and Proliferative Effects of Bone Marrow Adipocytes on Myeloid Leukemia Cells." Blood 114, no. 22 (2009): 4572. http://dx.doi.org/10.1182/blood.v114.22.4572.4572.

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Abstract Abstract 4572 Bone marrow stromal cells (MSCs) from elderly subjects have a reduced capacity to differentiate into osteoblasts and an increased capacity to differentiate into adipocytes, which leads to progressive accumulation of fat in the bone marrow space with increasing age. Adipocytes are the prevalent stromal cell type in adult BM that play an important role in the leukemic bone marrow microenvironment (Tabe et al., Blood 2004 103:1815-22). In this study, we examined the role of BM-derived adipocytes at different stages of differentiation on proliferation and apoptosis of AML ce
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Naveiras, Olaia, Valentina Nardi, Parul Sharma, Peter Hauschka, and George Q. Daley. "Bone Marrow Adipocytes: A Novel Negative Regulator of the Hematopoietic Microenvironment." Blood 110, no. 11 (2007): 1405. http://dx.doi.org/10.1182/blood.v110.11.1405.1405.

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Abstract In the bone marrow (BM), osteoblasts and endothelium constitute functional niches providing positive or negative signals for hematopoietic stem cell (HSC) self-renewal. In addition to hematopoietic cells, endothelial cells, and osteoblasts, adult BM contains numerous adipocytes. Interestingly, the number of adipocytes correlates inversely with the gross hematopoietic activity of the marrow. Whether adipocytes have a direct effect on hematopoietic progenitors or whether they act as mere space-fillers in this context remains unclear. To determine the potential role of bone marrow adipoc
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Horowitz, Mark C., Ryan Berry, Brandon Holtrup, et al. "Bone marrow adipocytes." Adipocyte 6, no. 3 (2017): 193–204. http://dx.doi.org/10.1080/21623945.2017.1367881.

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Kastrenopoulou, Afroditi, Kyriakos E. Kypreos, Nicholaos I. Papachristou, et al. "ApoA1 Deficiency Reshapes the Phenotypic and Molecular Characteristics of Bone Marrow Adipocytes in Mice." International Journal of Molecular Sciences 23, no. 9 (2022): 4834. http://dx.doi.org/10.3390/ijms23094834.

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In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized ApoA1 knockout mice. APOA1 is a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, and thus HDL; our recent work showed that deficiency of APOA1 increases bone marrow adiposity in mice. We found that ApoA1 deficient mice have greatly elevated adipocytes within their bone marrow compared to wild type counterparts. Morphologically, the increased adipocytes were similar to white adipocytes, and display
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Trotter, Timothy N., Tshering D. Lama-Sherpa, Deniz Peker, Amjad Javed, Larry J. Suva, and Yang Yang. "The Role of Adipocyte Lineage Cells in Myeloma Growth and Dissemination in Bone." Blood 126, no. 23 (2015): 1797. http://dx.doi.org/10.1182/blood.v126.23.1797.1797.

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Abstract Background: Multiple myeloma (MM) is hematologic malignancy of plasma cells that thrives in and progresses throughout the bone marrow microenvironment. The bone marrow is host to a variety of cell types, including bone marrow stromal cells and hematopoietic cells, as well as osteoblasts, osteoclasts and adipocytes. We and others have shown that MM cells not only alter the local bone microenvironment to support MM progression, but also modify distant bone sites through secretion of soluble factors before arrival of tumor cells. One critical alteration in bone is the shift of osteoblast
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Dissertations / Theses on the topic "Bone marrow adipocytes"

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MATTIUCCI, DOMENICO. "The regulation of haematopoietic niche: is there a role for Bone Marrow Adipocytes?" Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263669.

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Il midollo osseo (BM) è un microambiente altamente specializzato che fornisce supporto trofico e strutturale attraverso le sue componenti stromali alle cellule staminali emopoietiche (HSC). Gli adipociti midollari (BM-A) costituiscono la componente stromale più abbondante nella nicchia, tuttavia il loro ruolo nella regolazione dell’emopoiesi non è stato ancora ben definito. È stato tuttavia dimostrato che durante la CR avviene un’espansione del tessuto adiposo midollare, responsabile a sua volta di aumentati livelli di Adiponectina (APN) sierica circolante, un ormone potenzialmente coinvolto n
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Delikat, Sylvie. "Effects of interleukin 1#beta# on human bone marrow stromal cells, with particular relevance to adipocytes." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359186.

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Tang, Kai Dun. "Dissecting the prostate cancer stem cell niche inside the bone marrow." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/88935/1/Kai%20Dun_Tang_Thesis.pdf.

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Prostate cancer frequently metastasizes to bone, which becomes incurable; yet how cancer cells manage to migrate and grow inside the bone remains unknown. In this study I have discovered that both bone and fat cells within the bone marrow actively promote the survival and expansion of prostate cancer cells, and have subsequently developed approaches that can effectively inhibit these processes. Therefore, my work offers opportunities for the development of new prognostic and therapeutic approaches against metastatic prostate cancer and have the potential for improving the treatment outcome of
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Paquet, Amélie. "Peptides de l’immunité innée (défensines et cathélicidines) : expression dans les contextes d’obésité et de diabète de type 2, et lien avec la régulation fonctionnelle des adipocytes médullaires et l’os." Electronic Thesis or Diss., Littoral, 2024. https://documents.univ-littoral.fr/access/content/group/50b76a52-4e4b-4ade-a198-f84bc4e1bc3c/BULCO/Th%C3%A8ses/MABLab/123427_PAQUET_2024_archivage.pdf.

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L'obésité est un facteur de risque majeur de diabète de type 2 (DT2), favorisés par une inflammation systémique et une résistance à l'insuline. Ces pathologies métaboliques sont associées à une fragilité osseuse augmentant significativement le risque de fracture souvent sans modification de la masse osseuse. Elles s'accompagnent aussi d'un niveau de graisse dans la moelle osseuse (adiposité médullaire (AM)) anormalement élevé et suspectée de jouer un rôle délétère sur l'os. Cependant, les mécanismes responsables de l'accroissement de l'AM et ses conséquences sur l'os sont encore mal définis. L
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Mukohira, Hisa. "Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene." Kyoto University, 2020. http://hdl.handle.net/2433/253155.

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Mareddy, Shobha R. "Characterization of bone marrow stromal clonal populations derived from osteoarthritis patients." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/17151/1/Shobha_Reddy_Mareddy_Thesis.pdf.

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This work is concerned with the characterization of mesenchymal stem cells (MSC) specifically from bone marrow samples derived from patients with osteoarthritis (OA). The multilineage potential of mesenchymal stem cells as well as their ease of exvivo expansion makes these cells an attractive therapeutic tool for applications such as autologous transplantation and tissue engineering. Bone marrow is considered a source of MSC. However, there is a general assumption that the occurrence of MSCs and their activity in bone marrow diminishes with age and disease. This prompted us to isolate and iden
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Mareddy, Shobha R. "Characterization of bone marrow stromal clonal populations derived from osteoarthritis patients." Queensland University of Technology, 2008. http://eprints.qut.edu.au/17151/.

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This work is concerned with the characterization of mesenchymal stem cells (MSC) specifically from bone marrow samples derived from patients with osteoarthritis (OA). The multilineage potential of mesenchymal stem cells as well as their ease of exvivo expansion makes these cells an attractive therapeutic tool for applications such as autologous transplantation and tissue engineering. Bone marrow is considered a source of MSC. However, there is a general assumption that the occurrence of MSCs and their activity in bone marrow diminishes with age and disease. This prompted us to isolate and iden
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Withers, Catherine Nicole Kaminski. "RAD GTPASE: IDENTIFICATION OF NOVEL REGULATORY MECHANISMS AND A NEW FUNCTION IN MODULATION OF BONE DENSITY AND MARROW ADIPOSITY." UKnowledge, 2017. http://uknowledge.uky.edu/biochem_etds/34.

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The small GTP-binding protein Rad (RRAD, Ras associated with diabetes) is the founding member of the RGK (Rad, Rem, Rem2, and Gem/Kir) family that regulates voltage-dependent calcium channel function. Given its expression in both excitable and non-excitable cell types, the control mechanisms for Rad regulation and the potential for novel functions for Rad beyond calcium channel modulation are open questions. Here we report a novel interaction between Rad and Enigma, a scaffolding protein that also binds to the E3 ubiquitin ligase Smad ubiquitin regulatory factor 1 (Smurf1). Overexpression of S
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Anastassiadis, Konstantinos, and Maria Rostovskaya. "Differential Expression of Surface Markers in Mouse Bone Marrow Mesenchymal Stromal Cell Subpopulations with Distinct Lineage Commitment." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-191602.

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Bone marrow mesenchymal stromal cells (BM MSCs) represent a heterogeneous population of progenitors with potential for generation of skeletal tissues. However the identity of BM MSC subpopulations is poorly defined mainly due to the absence of specific markers allowing in situ localization of those cells and isolation of pure cell types. Here, we aimed at characterization of surface markers in mouse BM MSCs and in their subsets with distinct differentiation potential. Using conditionally immortalized BM MSCs we performed a screening with 176 antibodies and high-throughput flow cytometry, and f
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Anastassiadis, Konstantinos, and Maria Rostovskaya. "Differential Expression of Surface Markers in Mouse Bone Marrow Mesenchymal Stromal Cell Subpopulations with Distinct Lineage Commitment." Public Library of Science, 2012. https://tud.qucosa.de/id/qucosa%3A29135.

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Bone marrow mesenchymal stromal cells (BM MSCs) represent a heterogeneous population of progenitors with potential for generation of skeletal tissues. However the identity of BM MSC subpopulations is poorly defined mainly due to the absence of specific markers allowing in situ localization of those cells and isolation of pure cell types. Here, we aimed at characterization of surface markers in mouse BM MSCs and in their subsets with distinct differentiation potential. Using conditionally immortalized BM MSCs we performed a screening with 176 antibodies and high-throughput flow cytometry, and f
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Book chapters on the topic "Bone marrow adipocytes"

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Costa, Samantha N., Carolyn Chlebek, and Clifford J. Rosen. "Isolation and Characterization of Primary Bone Marrow Adipocytes in Rodent Models." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4306-8_5.

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Strauchen, James A. "Disorders of Bone Marrow Stroma." In Diagnostic Histopathology of the Bone Marrow. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195097566.003.0029.

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Abstract The bone marrow stroma consists of the supporting cells of the bone marrow, the bone marrow blood vessels and sinusoids, and the adipocytes. These elements may be involved in a variety of hematologic and nonhematologic disorders affecting the bone marrow. The disorders considered in this chapter include bone marrow infarction, vasculitis, and serous fat atrophy. Bone marrow infarction refers to coagulative necrosis of bone marrow elements. Bone marrow infarction occurs most frequently as a complication of neoplasms involving the bone marrow (Kiraly and Whelby, 1976), but is also seen
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Strauchen, James A. "The Normal Bone Marrow." In Diagnostic Histopathology of the Bone Marrow. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195097566.003.0002.

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Abstract The bone marrow is the major site of postnatal hematopoiesis. The bone marrow contains stromal elements (endothelial cells, fibroblast-like cells, adipocytes, macrophages), hematopoietic elements (stem cells, granulocytes, erythroid cells, megakaryocytes), and other elements (lymphocytes, plasma cells, and mast cells). Hematopoiesis is regulated and sustained by a complex cellular interaction of hematopoietic and stromal elements and a network of cytokine growth factors, including the interleukins (11-1, 11-3, 11-5, 11- 6, 11-7, 11-11, stem cell factor) and colony-stimulating factors
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Sotoca, Ana M., Michael Weber, and Everardus J. J. van Zoelen. "Gene Expression Regulation underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells." In Medical Advancements in Aging and Regenerative Technologies. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2506-8.ch004.

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Human mesenchymal stem cells have a high potential in regenerative medicine. They can be isolated from a variety of adult tissues, including bone marrow, and can be differentiated into multiple cell types of the mesodermal lineage, including adipocytes, osteocytes, and chondrocytes. Stem cell differentiation is controlled by a process of interacting lineage-specific and multipotent genes. In this chapter, the authors use full genome microarrays to explore gene expression profiles in the process of Osteo-, Adipo-, and Chondro-Genic lineage commitment of human mesenchymal stem cells.
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Li, Chenghai. "Isolation and Expansion of Mesenchymal Stem/Stromal Cells, Functional Assays and Long-Term Culture Associated Alterations of Cellular Properties." In Cell Culture [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100286.

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Mesenchymal stem cell/stromal cells (MSCs) can differentiate into a variety of cell types, including osteocytes, adipocytes and chondrocytes. MSCs are present in the multiple types of adult tissue, such as bone marrow, adipose tissue, and various neonatal birth-associated tissues. Given their self-renewal and differentiation potential, immunomodulatory and paracrine properties, and lacking major histocompatibility complex (MHC) class II molecules, MSCs have attracted much attention for stem cell-based translational medicine research. Due to a very low frequency in different types of tissue, MS
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Bubnovskaya, L., I. Ganusevich, S. Merentsev, and D. Osinsky. "The Impact of Cancer-associated Adipocytes on Prognostic Value of CD8 and CD45RO T Lymphocytes in Tumor and Bone Marrow and Survival of Patients with Gastric Cancer with Obesity." In Achievements and Challenges of Medicine and Medical Science Vol. 5. BP International, 2024. https://doi.org/10.9734/bpi/acmms/v5/2481.

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Beck, GR, CE Camalier, G. Bouloux, L. Peng, NB Khazai, and GE Umpierrez. "Defining the Effects of Thiazolidinediones on Osteoblast and Adipocyte Lineage Differentiation from Human Bone Marrow Stem Cells." In The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part2.p4.p2-185.

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Conference papers on the topic "Bone marrow adipocytes"

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Fritton, J. Christopher, Yuki Kawashima, Hui Sun, et al. "Bone Marrow Adipogenesis Is Affected by Insulin-Like Growth Factor-1 Complexes." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206158.

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Fat tissue, which is composed of lipid-filled adipocytes that accumulate during aging, displaces mineralized tissue and reduces the mechanical integrity bone. Bone marrow adipocytes provide stroma for maintenance of mesencymal stem cells (MSC) and reside at sites of bone turnover (i.e., endosteal surfaces where osteoblasts form new bone), potentially influencing cell activity via a paracrine route.
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Coughlin, Thomas R., Matthew Haugh, Muriel Voisin, Evelyn Birmingham, Laoise M. McNamara, and Glen L. Niebur. "Primary Cilia Knockdown Reduces the Number of Stromal Cells in Three Dimensional Ex Vivo Culture." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14723.

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Mesenchymal stem cells (MSCs) are multipotent stromal cells that reside in the bone marrow and differentiate into connective cell lines, such as adipocytes and osteoblasts [1]. An appropriate balance of MSC differentiation toward adipocytes and osteoblasts is vital to bone homeostasis [6]. In vitro work demonstrates that differentiation of MSCs is influenced by mechanical stimuli [2, 3]. In a mouse model, the ratio of adipocytes to MSCs in the marrow was 19% lower compared to controls following treatment by low magnitude mechanical signals (LMMS) [4]. In mice, LMMS increased MSC number by 46%
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Herroon, Mackenzie K., Erandi Rajagurubandara, Aimalie L. Hardaway, and Izabela Podgorski. "Abstract B04: Exploring the roles of bone marrow adipocytes in metabolic adaptation of metastatic prostate tumors in bone." In Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; February 26 — March 1, 2014; San Diego, CA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.chtme14-b04.

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Cugno, Chiara, Ganesh Halade, and Md Mizanur Rahman. "Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging mice." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0099.

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Rosiglitazone is an effective insulin-sensitizer, however, associated with bone loss mainly due to increased bone resorption, and bone marrow adiposity, and decreased bone formation. We investigated the effect of the co-administration of fish oil (FO) rich in omega-3 fatty acids (FAs) on rosiglitazone (RSG)-induced bone loss in aging C57BL/6 mice and the mechanisms underlying potential preventive effect. Mice fed the iso-caloric diet supplemented with fish oil exhibited significantly higher levels of bone density in different regions compared to the other groups. In the same cohort of mice, re
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Ibrahim, Khadega, Chiara Cugno, and Md Mizanur Rahman. "Conjugated Linoleic Acid (CLA) co-treatment alleviates antidiabetic drug, rosiglitazone associated deterioration of bone remodeling." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0148.

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Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to decreased insulin secretion, defective action or both. The rosiglitazone (RSG) is one of the oral antidiabetic drug used in type 2 (T2) DM and has a unique insulin-sensitizing capacity. However, RSG has a negative side effect on the bone as it stimulates the differentiation of bone marrow-mesenchymal stromal cells (BM-MSCs) into adipocytes at the expense of osteoblasts in the bone marrow microenvironment, disturbing the normal balance of bone remodeling and causing BM adiposity. On the other hand, the t
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Liu, Chun, Seungik Baek, and Christina Chan. "The Complementary Effect of Mechanical and Chemical Stimuli on the Neural Differentiation of Mesenchymal Stem Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80131.

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Mesenchymal stem cells (MSCs), derived from bone marrow stroma, are a promising source for tissue repair and regeneration, due to their excellent abilities for proliferation and multipotent differentiation. While accumulated evidences during the past decade have shown that MSCs are able to differentiate into osteoblasts, chondrocytes, myoblasts and adipocytes, more recent research suggest their potential in neuronal differentiation [1]. Chemical stimuli, including growth factors, hormones, and other regulatory molecules, are used traditionally to direct MSC differentiation. Our group has previ
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Diedrich, Jonathan, Erandi Rajagurubandara, Mackenzie Herroon, and Izabela Podgorski. "Abstract LB-315: Bone marrow adipocytes alter the metabolic phenotype of metastatic prostate cancer cells through the activation of HIF-1a." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-lb-315.

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Van Dyke, William S., Ozan Akkus, and Eric Nauman. "Murine Osteochondral Stem Cells Express Collagen Type I More Strongly on PDMS Substrates Than on Tissue Culture Plastic." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14272.

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The discovery of the multipotent lineage of mesenchymal stem cells has dawned a new age in tissue engineering, where an autologous cell-seeded scaffold can be implanted into different therapeutic sites. Mesenchymal stem cells have been reported to differentiate into numerous anchorage-dependent cell phenotypes, including neurons, adipocytes, myoblasts, chondrocytes, tenocytes, and osteoblasts. A seminal work detailing that mesenchymal stem cells can be directed towards differentiation of different cell types by substrate stiffness alone [1] has led to numerous studies attempting to understand
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Shafat, Manar, Thomas Oellerich, Sebastian Mohr, et al. "Abstract 4327: Bone marrow adipocytes drive transcriptional changes in leukemic blasts to enhance their capacity to derive energy from free fatty acid metabolism." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-4327.

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Grubač, Siniša, Marko Cincović, Jože Starič, Marinković Došenović, Biljana Delić-Vujanović, and Jasna Prodanov-Radulović. "The relationship of the metabolism of iron, organic matter and phlebotomy with the erythropoiesis of ruminants." In Zbornik radova 26. medunarodni kongres Mediteranske federacije za zdravlje i produkciju preživara - FeMeSPRum. Poljoprivredni fakultet Novi Sad, 2024. http://dx.doi.org/10.5937/femesprumns24012g.

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Erythropesis is the process of making red blood cells and it is related to numerous factors in the body. Iron is important because of its role in the process of making hemoglobin. In addition to the mentioned iron, it is an indirect indicator of inflammation and is regulated at the systemic and cellular level, so its lack speaks of the overall health status of individuals. Fe deficiency in the body takes place through three phases. In the first phase, there is emptying of tissue depots, but its total amount in the circulation increases, then follows the second phase or the phase of real defici
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