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Journal articles on the topic 'Bone marrow infiltration'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gerlach, Magdalena M., Darius Juskevicius, Visar Vela, Stefan Dirnhofer, and Alexandar Tzankov. "Bone Marrow Infiltration of Angioimmunoblastic T-Cell Lymphoma: Identification and Prognostic Impact of Histologic Patterns and Diagnostic Application of Ancillary Phenotypic and Molecular Analyses." Archives of Pathology & Laboratory Medicine 144, no. 5 (2019): 602–11. http://dx.doi.org/10.5858/arpa.2019-0007-oa.

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Context.— Angioimmunoblastic T-cell lymphomas originate from T follicular helper cells and express respective markers (BCL6, CD10, CXCL13, ICOS, and PD-1). Although commonly present, bone marrow involvement by angioimmunoblastic T-cell lymphoma can be diagnostically challenging. Additionally, only little is known about the distribution of T follicular helper cells in healthy and reactively changed bone marrows or in samples affected by other lymphomas. Objective.— To establish a diagnostic approach to reliably identify bone marrow infiltration of angioimmunoblastic T-cell lymphoma. Design.— We

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Dr., Amna Bakhtiar Dr. Maria Rehman Dr.Sadaf Zafar. "OUTCOME OF BONE MARROW BIOPSIES PERFORMED AT TERTIARY CARE HOSPITAL IN ISLAMABAD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 7841–44. https://doi.org/10.5281/zenodo.1402673.

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<em>Objective: To compare the outcome of bone marrow aspirate with the referral diagnosis and to study the pattern of different hematological abnormalities by bone marrow biopsy </em> <em>Study Design: Cross sectional descriptive study</em> <em>Duration: 1st January 2018 to 30th April 2018</em> <em>SETTING: Department of pathology, Pakistan institute of medical sciences, Islamabad</em> <em>Materials and Methods: Bone marrow biopsies of 180 patients performed during 4 month’s period were assessed. Physician’s referral and the final report of the bone marrow biopsy were recorded. Dat

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Kim, Ki Hwan, and Ho Young Lee. "Bone marrow infiltration of lymphoma." Korean Journal of Hematology 45, no. 3 (2010): 151. http://dx.doi.org/10.5045/kjh.2010.45.3.151.

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Reid, M. M., and A. D. J. Pearson. "Bone-marrow infiltration in neuroblastoma." Lancet 337, no. 8742 (1991): 681–82. http://dx.doi.org/10.1016/0140-6736(91)92506-w.

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Rathinasamy, Anchana, Steffen Dettling, Yingzi Ge, et al. "Emigration of tumor specific regulatory T cells from the bone marrow is triggered by S1P1 and correlates with their accumulation in breast tumors (TUM9P.1001)." Journal of Immunology 194, no. 1_Supplement (2015): 210.3. http://dx.doi.org/10.4049/jimmunol.194.supp.210.3.

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Abstract High regulatory T cell (Treg) infiltration in breast tumors is associated with reduced survival. However, the source of tumor infiltrating Treg and signals underlying their migration from lymphoid organs to the tumor tissue remain elusive. We here demonstrate that pronounced Treg infiltration in human breast tumors correlates with a selective reduction of tumor antigen specifc Treg from the bone marrow. Using MHC-II tumor peptide tetramers we furthermore show that tumor specific bone marrow Treg selectively express Sphingosine-1-phosphate receptor 1 (S1P1), the receptor that mediates

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Chulkova, S. V., E. N. Sholokhova, I. V. Poddubnaya, et al. "The relationship of lymphoid populations (infiltration) of the primary tumor with bone marrow immune responses in patients with breast cancer." Russian Journal of Biotherapy 22, no. 1 (2023): 49–61. http://dx.doi.org/10.17650/1726-9784-2023-22-1-49-61.

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Backgraund. Currently, immunotherapy is firmly established in the standard of cancer treatment. The basis for the appointment of immunotherapy are immunological tumor markers, which include lymphoid infiltration, a detailed study of which has received increasing attention in the last decade. An undoubted interest is the study of lymphoid infiltration, not only depending on the morpho-clinical parameters of breast cancer (BC), but also on the immune system of the bone marrow.Aim. To evaluate the infiltration of the primary tumor by lymphocytes depending on the morpho-clinical characteristics of

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Wang, Tiantian, Biao Zhou, Kui Zhang, Chen Yan, and Xiangzhen Guan. "Value of third-generation of VNCa dual-energy CT for differentiating diffuse marrow infiltration of multiple myeloma from red bone marrow." Medicine 103, no. 18 (2024): e38003. http://dx.doi.org/10.1097/md.0000000000038003.

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This study aims to investigate the ability of bone marrow imaging using third-generation dual-energy computed tomography (CT) virtual noncalcium (VNCa) to differentiate between multiple myeloma (MM) with diffuse bone marrow infiltration and red bone marrow (RBM). Bone marrow aspiration or follow-up results were used as reference. We retrospectively reviewed 188 regions of interests (ROIs) from 21 patients with confirmed MM and diffuse bone marrow infiltrations who underwent VNCa bone marrow imaging between May 2019 and September 2022. At the same time, we obtained 98 ROIs from 11 subjects with

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Moyo, Tamara K., Anass Bouchnita, Nathalie Eymard, Vitaly Volpert, and Mark J. Koury. "Effects of Bone Marrow Infiltration By Multiple Myeloma on Erythropoiesis." Blood 126, no. 23 (2015): 2143. http://dx.doi.org/10.1182/blood.v126.23.2143.2143.

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Abstract Diseases that infiltrate the bone marrow disrupt erythropoiesis leading to anemia. In multiple myeloma (MM), anemia severity can be correlated with degree of marrow infiltration by myeloma cells. Infiltrating MM may impair the function and structure of erythroblastic islands (EBIs), the marrow erythropoietic niches. An EBI consists of a central macrophage surrounded by colony-forming units-erythroid/proerythroblasts (CFU-E/pro-EBs) and their progeny, the differentiating erythroblasts. Cytokines produced by MM cells, such as Fas ligand (FL), tumor necrosis factor (TNF), and TNF-related

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Rahali, Fatima Zahra, Fatima Taher, Houda Nassih, and Sanae Sayagh. "Bone Marrow Infiltration in Rosai–Dorfman Disease." Case Reports in Hematology 2022 (December 15, 2022): 1–5. http://dx.doi.org/10.1155/2022/3420311.

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Rosai–Dorfman disease (RDD) is a rare and benign nonLangerhans cell histiocytosis. RDD commonly affects children and young adults typically presenting with massive, painless, and bilateral cervical lymphadenopathy. Extranodal involvement is present in about 40% of cases, and bone marrow infiltration is rare and unusual. RDD prognosis is usually good, however, involvement of bone marrow is associated with poor prognosis. We report a case of RDD with bone marrow involvement occurring in a 5-year-old female. She was admitted for asthenia, gingival bleeding, and diffuse bone pain without fever. Ph

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Mitani, Sachiko, Hitomi Kaneko, and Kazunori Imada. "Bone marrow infiltration of histiocytic sarcoma." Blood Research 53, no. 3 (2018): 185. http://dx.doi.org/10.5045/br.2018.53.3.185.

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Seshadri, Nagabushan, Penny Wright, and Kottekkattu K. Balan. "Rhabdomyosarcoma With Widespread Bone Marrow Infiltration." Clinical Nuclear Medicine 32, no. 10 (2007): 787–89. http://dx.doi.org/10.1097/rlu.0b013e318148b434.

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Zankovich, R., P. Theissen, G. Schauerte, V. Diehl, H. Schicha, and A. Linden. "Knochenmarkszintigraphie und Kernspintomographie bei malignen Lymphomen: Vergleich mit histologischen Ergebnissen." Nuklearmedizin 28, no. 05 (1989): 166–71. http://dx.doi.org/10.1055/s-0038-1629487.

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One hundred and seven patients with malignant Hodgkin and non-Hodgkin lymphoma were examined by bone marrow scintigraphy, MRI of bone marrow and bone marrow biopsy to detect bone marrow infiltration. The study included 2 patients where autopsy findings were subsequently available, 3 patients with blind rebiopsy and one patient with guided rebiopsy. The findings of bone marrow imaging and biopsy were classified as normal (grade 0), suggesting reactive changes of bone marrow (grade 1) or suspicious for infiltration (grade 2). About half of all results of biopsy and imaging methods agreed complet

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Zhao, Yu, Jianzhen Shen, Tingbo Liu, and Xiaofan Li. "Diagnostic and Prognostic Evaluation Value of 18f-FDG PET-CT for Bone Marrow Infiltration in Primary Treated Follicular Lymphoma." Blood 142, Supplement 1 (2023): 6154. http://dx.doi.org/10.1182/blood-2023-186231.

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Objective ：The purpose of this paper is to evaluate the value of 18F-FDG PET-CT in the diagnosis of bone marrow infiltration in patients with primary treated follicular lymphoma and whether it provides valuable information for staging and prognosis. Methods ：This is a retrospective analysis of 199 hospitalized patients with primary 1-3a follicular lymphoma diagnosed by pathological examination from January 01, 2014 to September 31, 2022 in Fujian Medical University's Union Hospital. The recorded clinical characteristics, bone marrow examination, the result of 18F-FDG PET-CT for bone marrow inv

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Altehoefer, C., U. Blum, J. Bathmann, et al. "Comparative diagnostic accuracy of magnetic resonance imaging and immunoscintigraphy for detection of bone marrow involvement in patients with malignant lymphoma." Journal of Clinical Oncology 15, no. 5 (1997): 1754–60. http://dx.doi.org/10.1200/jco.1997.15.5.1754.

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PURPOSE To compare the diagnostic accuracy of magnetic resonance imaging (MRI) and immunoscintigraphy (IS) for detection of bone marrow infiltration in malignant lymphoma. PATIENTS AND METHODS In 32 patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL), MRI of the axial skeleton and whole-body IS using technetium-99m (99mTc)-labeled monoclonal antibodies were reviewed and compared with iliac crest biopsies. Criterion for marrow infiltration was a positive biopsy or concordant positive results of MRI and IS. RESULTS In 16 patients (50%), MRI, IS, and iliac crest biopsies were neg

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Sahu, Manoj, Mansi Gupta, Saurabh Sharma, Anshul Gupta, and Ashish Shriwastava. "Results of Autogenous Bone Marrow Injection in Delayed Union Cases of Open Fractures of Tibial Shaft Treated by Various Surgical Procedures." International Journal of Pharmaceutical and Clinical Research 15, no. 9 (2023): 1572–74. https://doi.org/10.5281/zenodo.11391896.

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<strong>Introduction: </strong>Tibia is the most commonly fractured long bone from its shaft.<sup>1</sup>Tibial fractures are most common fracture among long bones with complications of delayed union, non-union and infection. The purpose of this study to access the role of bone marrow infiltration in delayed union, non-union cases as this method is quick, easy and effective. <strong>Material and Methods: </strong>36 patients’ cases of displaced compound fracture of tibial shaft selected for bone marrow infiltration treated by conservative method, external fixator and intra

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Ohata, Shinya, Kei Takenaka, Daisuke Sugiyama, and Takeshi Sugimoto. "Bone Marrow Infiltration Is a Distinctive Risk Factor for Rituximab Infusion-Related Reactions in CD20-Positive B-Cell Non-Hodgkin Lymphoma." Advances in Hematology 2022 (February 11, 2022): 1–7. http://dx.doi.org/10.1155/2022/3688727.

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Background. Bone marrow infiltration of lymphoma cells is a candidate risk factor for infusion-related reactions (IRRs) in patients with CD20-positive B-cell non-Hodgkin lymphoma (B-NHL). However, despite with the lack of sufficient data, the effect of bone marrow infiltration of B-NHL cells on the incidence rate of grade 2 or higher IRRs with the administration of rituximab has been retrospectively studied in this paper. Methods. Patients with CD20-positive B-NHL who received the rituximab induction therapy for the first time were enrolled in this study. To evaluate the bone marrow infiltrati

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Rathinasamy, Anchana, Hans-Henning Böhm, Yingzi Ge, et al. "Tumor antigen specific Treg from the bone marrow migrate towards increased S1P and CCL2 gradients established in the blood of breast cancer patients." Journal of Immunology 196, no. 1_Supplement (2016): 211.1. http://dx.doi.org/10.4049/jimmunol.196.supp.211.1.

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Abstract High regulatory T cell (Treg) infiltration in breast tumors is associated with reduced survival. However, the source of tumor infiltrating Treg and signals underlying their migration from lymphoid organs to the tumor tissue remain elusive. We here demonstrate that pronounced Treg infiltration in human breast tumors correlates with a selective reduction of tumor antigen specifc Treg from the bone marrow. Furthermore using MHC-II tumor peptide tetramers we show that tumor antigen specific bone marrow Treg selectively express the egress receptor Sphingosine-1-phosphate receptor 1 (S1P1)

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Mead, Graham P., Steven D. Reid, Bradley M. Augustson, Mark T. Drayson, Arthur R. Bradwell, and J. Anthony Child. "Correlation of Serum Free Light Chains and Bone Marrow Plasma Cell Infiltration in Multiple Myeloma." Blood 104, no. 11 (2004): 4865. http://dx.doi.org/10.1182/blood.v104.11.4865.4865.

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Abstract Diagnostic criteria for multiple myeloma include abnormal plasma cell infiltration of the bone marrow plus the presence of monoclonal immunoglobulin in the serum and/or monoclonal free light chains in the urine. However, recent studies have indicated that measurement of free light chains in the serum (sFLC) is more sensitive than urine assays. Also, because of the slow clearance of IgG from serum (half-life ~20 days compared with 2–6 hours for sFLC) intact immunoglobulin assays can be slow to reflect the full extent of response to treatment. The aim of this study was to compare the re

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Parrens, M., P. Dubus, P. Agape, et al. "Intrasinusoidal Bone Marrow Infiltration Revealing Intravascular Lymphomatosis." Leukemia & Lymphoma 37, no. 1-2 (2000): 219–23. http://dx.doi.org/10.3109/10428190009057649.

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Wang, Kun, Zhihong Chen, Yanchun Li, and Zhiqun Mao. "Alveolar rhabdomyosarcoma with multiple bone marrow infiltration." Lancet Oncology 24, no. 5 (2023): e228. http://dx.doi.org/10.1016/s1470-2045(23)00015-3.

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21

Harahap, Agnes Stephanie, Endang S. R. Hardjolukito, Elly Yanah Arwanih, Naivedh Bhat, and Maria Francisca Ham. "Role of Immunohistochemistry and Quantitative PCR in Detection of B-Cell Lymphoma Infiltration in Bone Marrow." Advanced Science Letters 24, no. 8 (2018): 6232–37. http://dx.doi.org/10.1166/asl.2018.12695.

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Bone marrow infiltration of malignant lymphoma is essential for staging and prognosis, and could be detected by trephine biopsy. Using routine Hematoxylin and Eosin (HE) staining alone cannot accurately identify infiltration of lymphoma in bone marrow, therefore alternative techniques may be needed. Fifty-three bone marrow biopsies of B-cell lymphoma cases with age ranged from 29 to 74 year-old were included. Lengths of the bone marrow samples were measured and sent for routine HE and immunohistochemistry (IHC) staining. Results were categorized into 3 groups; positive, negative and equivocal.

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Nakayama, Shoko, Taiji Yokote, Nobuya Hiraoka та ін. "Interleukin-13- and Tansforming Growth Factor-β- Producing Mast Cells Are Associated with Fibrosis in Bone Marrow". Blood 128, № 22 (2016): 3112. http://dx.doi.org/10.1182/blood.v128.22.3112.3112.

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Abstract Background: Fibrosis in bone marrow is a lethal condition, which currently has no effective treatments. Transforming growth factor (TGF)-β, produced by megakaryocytes and blasts in myelodisplastic syndrome (MDS) with bone marrow fibrosis, is reportedly linked to this condition; however, the underlying mechanism of fibrosis in bone marrow remains uncharacterized. Recently, interleukin (IL)-13- and TGF-β- producing mast cells have been reported to participate in the development of fibrosis in certain fibrotic diseases, such as the IgG4-related diseases. Aim: This study aimed to investig

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Haque, Salina, Zulfia Zinat Chowdhury, AKM Mynul Islam, et al. "Bone Marrow Involvement in Non-Hodgkin Lymphoma at Diagnosis." Haematology Journal of Bangladesh 3, no. 01 (2019): 3–7. http://dx.doi.org/10.37545/haematoljbd201926.

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Background: In lymphoma, bone marrow infiltration of lymphocytes is a vital information of staging can be done primarily by observer dependent bone marrow study or trephine biopsy. Objective: Aim of this study is to observe the frequency of bone marrow involvement in Non-Hodgkin lymphoma at the time of diagnosis by trephine biopsy and to determine importance of bone marrow trephine biopsy over bone marrow aspiration for staging of Non-Hodgkin lymphoma. Methodology: This was a prospective observational study conducted between January 2014 to July 2014 in department of Haematology, Bangabandhu S

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De Bernardi, B., S. Sorrentino, M. Pasino, et al. "Bone marrow infiltration in infants with disseminated neuroblastoma." Journal of Clinical Oncology 27, no. 15_suppl (2009): 10056. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.10056.

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10056 Background: The INSS definition of stage 4S neuroblastoma allows a bone marrow infiltration (BMI) no greater than 10%. More extensive involvement is to be consider stage 4. However, the degree of BMI may be difficult to establish, since tumor cells in the marrow commonly aggregate in clumps. So far, no studies have specifically investigated this issue. In this study we have reviewed the bone marrow slides of infants with disseminated neuroblastoma enrolled between January 1998 and July 2008 in the Italian Neuroblastoma Registry. Methods: BMI was arbitrarily considered <10% when it con

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Park, Hyerim, So-Yeon Lee, Jooyeon Lee, et al. "Detecting Multiple Myeloma Infiltration of the Bone Marrow on CT Scans in Patients with Osteopenia: Feasibility of Radiomics Analysis." Diagnostics 12, no. 4 (2022): 923. http://dx.doi.org/10.3390/diagnostics12040923.

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It is difficult to detect multiple myeloma (MM) infiltration of the bone marrow on computed tomography (CT) scans of patients with osteopenia. Our aim is to determine the feasibility of using radiomics analysis to detect MM infiltration of the bone marrow on CT scans of patients with osteopenia. The contrast-enhanced thoracic CT scans of 104 patients with MM and 104 age- and sex-matched controls were retrospectively evaluated. All individuals had decreased bone density on radiography. The study group was divided into development (n = 160) and temporal validation sets (n = 48). The radiomics mo

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Anandani, Garima M., Prabhu Manivannan, Sree Rekha J, Rakhee Kar, and Debdatta Basu. "Patterns of bone marrow infiltration in lymphomas- A retrospective descriptive analysis from a tertiary care centre in Southern India." IP Journal of Diagnostic Pathology and Oncology 7, no. 4 (2023): 223–28. http://dx.doi.org/10.18231/j.jdpo.2022.053.

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Bone marrow biopsy (BMB) examination is the gold standard for staging of lymphoma which is interpreted along with other clinical, laboratory and radiological investigations. This study aimed to evaluate the various patterns of BMB infiltration by lymphomas which include Hodgkin and Non Hodgkin lymphoma and the usefulness of BMB compared to bone marrow aspiration (BMA). : In a period of three years, there were 212 cases which showed lymphoma infiltration in bone marrow. We assessed the peripheral blood smear (PBS), BMA and BMB slides and concordance between each was evaluated. BMB slides were a

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Cheng, Justin J., Ryan T. Mott, Paul D. Savage, and Ravi K. Paluri. "Metastatic Alveolar Rhabdomyosarcoma with Extensive Bone Marrow Replacement in an Older Adult." Case Reports in Oncology 14, no. 3 (2021): 1505–10. http://dx.doi.org/10.1159/000519595.

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Rhabdomyosarcoma is extremely rare in adults. Metastatic rhabdomyosarcoma can resemble other malignancies, which can delay diagnosis and prompt treatment. This case illustrates an example of metastatic alveolar rhabdomyosarcoma with concurrent bone marrow infiltration. A 67-year-old woman presented with epistaxis and diffuse bone pain. She developed progressive thrombocytopenia requiring platelet transfusions. The patient was initially thought to have leukemia. She was found to have a large sinonasal mass with extensive metastatic disease and bone marrow infiltration. The patient was ultimatel

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Garcia-Reyero, Julia, Nerea Martinez Magunacelaya, Sonia Gonzalez de Villambrosia, et al. "Diagnostic value of bone marrow core biopsy patterns in lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia and description of its mutational profiles by targeted NGS." Journal of Clinical Pathology 73, no. 9 (2020): 571–77. http://dx.doi.org/10.1136/jclinpath-2019-206282.

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AimsThe aim of this study was to describe the characteristics of the bone marrow infiltration found in a series of clinically defined lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinaemia (WM) and IgM-monoclonal gammopathy of undetermined significance (MGUS) and to perform a targeted next-generation sequencing (NGS) for the identification of additional somatic mutations to MYD88p.L265P in LPL/WM.MethodsWe have reviewed a series of 35 bone marrow biopsies from 28 patients with a clinical diagnosis of LPL/WM (24 cases) or MGUS (4 cases). Bone marrow infiltration characteristics by morp

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Surekha, Yeresime, and Belurkar Sushma. "Clinicopathological Study of Bone Marrow Infiltration in Lymphoma." International Journal of Current Research and Review 13, no. 22 (2021): 61–67. http://dx.doi.org/10.31782/ijcrr.2021.132213.

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Olgun, N., H. Ören, B. Ören, G. İrken, M. Polat, and N. Çevik. "Diffuse Erythrodermic Cutaneous Mastocytosis with Bone Marrow Infiltration." Dermatology 187, no. 2 (1993): 127–29. http://dx.doi.org/10.1159/000247222.

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Mirza, Rusella, James Cotelingam, Nebu Koshy, and Ailing Li. "CD8+ Cytotoxic Mycosis Fungoides With Bone Marrow Infiltration." American Journal of Clinical Pathology 150, suppl_1 (2018): S14. http://dx.doi.org/10.1093/ajcp/aqy090.033.

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Mirza, Rusella, Nebu Koshy, and James Cotelingam. "CD8+ Cytotoxic Mycosis Fungoides With Bone Marrow Infiltration." American Journal of Clinical Pathology 150, suppl_1 (2018): S96. http://dx.doi.org/10.1093/ajcp/aqy097.232.

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Suhail, Maymoona, Asad Mahmood, Rafia Mahmood, Saima Zahir, Syeda Samia Shafaat, and Sumaira Illyas. "Bone marrow infiltration by Non-Hodgkin lymphoma: An experience in a tertiary care centre." Journal of the Pakistan Medical Association 73, no. 3 (2023): 558–61. http://dx.doi.org/10.47391/jpma.6730.

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Objective: To determine the frequency and patterns of bone marrow infiltration in non-Hodgkin lymphoma patients. Method: The cross-sectional study was conducted at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from April to October 2021, and comprised patients of either gender aged 20-80 years who had been diagnosed with non-Hodgkin lymphoma. Following assessment and as per standard protocol, bone marrow aspirate and trephine biopsy were done on all patients from the posterior superior iliac spine, and slides were prepared and assessed. Data was analysed using SPSS 25. Results

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Lutsik, N. S., L. P. Mendeleeva, and G. A. Yatsik. "Informative value of whole-body magnetic resonance imaging with diffusion-weighted images for the detection of bone marrow infiltration in patients with multiple myeloma (literature review)." Oncohematology 17, no. 1 (2022): 87–94. http://dx.doi.org/10.17650/1818-8346-2022-17-1-87-94.

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Magnetic resonance imaging (MRI) is increasingly being used to diagnose bone marrow lesions in patients with multiple myeloma (MM). Since 2014, the results of MRI have been included in the updated criteria of the International Myeloma Working Group. The presence of >1 bone marrow lesion larger than or equal to 5 mm on MRI is considered sufficient for the diagnosis of symptomatic MM, requiring initiation of treatment. MRI assessment of bone marrow is also possible with functional sequences such as diffusion-weighted imaging (DWI), which provide additional information about the bone marrow. T

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Zentilin, Lorena, Sabrina Tafuro, Serena Zacchigna, et al. "Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels." Blood 107, no. 9 (2006): 3546–54. http://dx.doi.org/10.1182/blood-2005-08-3215.

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Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel formation during both vasculogenesis and angiogenesis. The prolonged expression of VEGF in the normoperfused skeletal muscles of adult rodents after gene transfer using AAV vectors induces the formation of a large set of new capillaries and small arteries. Notably, this process is accompanied by the massive infiltration by mononuclear cells. This observation raises the possibility that these cells might represent circulating progenitors that are eventually incorporated in the newly formed vessels. Here we explore this

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Decaux, Olivier, Thierry Josseaume, Eric Brillet, et al. "Interest of Diffusion Weighted Magnetic Resonance Imaging for the Evaluation of Bone Marrow Infiltration in Multiple Myeloma, Smoldering Myeloma and Monoclonal Gammopathy of Undetermined Significance." Blood 114, no. 22 (2009): 4874. http://dx.doi.org/10.1182/blood.v114.22.4874.4874.

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Abstract Abstract 4874 Introduction Monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM) are two asymptomatic early stages of multiple myeloma, and are characterized by the absence of bone involvement. In contrast, bone lytic lesions are common complications of multiple myeloma. Magnetic resonance imaging (MRI) has improved the evaluation of bone involvement in multiple myeloma. Moreover MRI allows visualization of the medullary cavity and a direct assessment of the degree of myeloma cell infiltration before bone destruction becomes visible on plain radiographs

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Eng, V. M., B. D. Car, B. Schnyder, et al. "The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo." Journal of Experimental Medicine 181, no. 5 (1995): 1893–98. http://dx.doi.org/10.1084/jem.181.5.1893.

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Interleukin (IL)-12 synergizes with other cytokines to stimulate the proliferation and differentiation of early hematopoietic progenitors in vitro. However, in vivo administration of IL-12 decreases peripheral blood counts and bone marrow hematopoiesis. Here, we used interferon (IFN) gamma receptor-deficient (IFN gamma R-/-) mice to investigate whether the in vivo inhibition of hematopoiesis by IL-12 is indirectly mediated by IL-12-induced IFN-gamma. IL-12 administered for 4 d (1 microgram/mouse per day) resulted in lower peripheral blood counts and a 2-fold decrease in bone marrow cellularity

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Ding, Wei, Sara J. Achenbach, Kari G. Chaffee, et al. "Correlation Between Peripheral Blood Counts and Extent of Bone Marrow Infiltration in Chronic Lymphocytic Leukemia." Blood 126, no. 23 (2015): 2926. http://dx.doi.org/10.1182/blood.v126.23.2926.2926.

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Abstract Background Severe cytopenias in CLL are typically associated with bone marrow failure due to massive infiltration of the bone marrow by leukemic cells and negatively impact patient morbidity/mortality. Although near complete marrow replacement by CLL is typically observed in patients whose degree of cytopenia meet criteria for advanced Rai stage disease (Hg<11g/dL; platelet <100 x10^9/L), profound variability in the degree of cytopenia and the extent of marrow infiltration exists, and the relationship between these dimensions is not well characterized. Methods We used the Mayo C

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Adam, Mujahed, ismail Khalid, ali Ali, and alkhair Idris. "Uncommon Case of Light Chain Primary Amyloidosis with Negative Bence Jones Protein and Positive Congo Red Stain in A 31 Years Old Sudanese Patient." Case Reports and Series in Medicine 1, no. 3 (2024): 1. https://doi.org/10.5455/crsm.20241124010509.

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A 31 years old male non diabetic or hypertensive, medically free who had unremarkable part of mild hepatosplenomegally, loss of weight and immunoglobulin light chain (AL) Amyloidosis. This patient underwent Trephine biopsy and Bone Marrow aspiration to confirm the diagnosis. Light microscopy showed deposition of Amyloid, focal areas with excess infiltration by plasma cells, cytoplasmic and background infiltration by eosinophilic materials is noted in Trephine biopsy without fibrosis. slightly blood diluted bone marrow aspirate with scattered granulocytes and plasma cells. Touch imprint showed

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Cheng, Hui, Sha Hao, Yanfeng Liu, et al. "Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation." Blood 126, no. 11 (2015): 1302–13. http://dx.doi.org/10.1182/blood-2015-01-623645.

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Key Points Increased quiescence of HSCs and HPCs in leukemogenesis, and reversible suppression of HSCs was observed in leukemic bone marrow. A novel inhibitory role of Egr3 in HSC proliferation was revealed by leukemic infiltration in bone marrow.

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Freedman, A. S., T. Takvorian, K. C. Anderson, et al. "Autologous bone marrow transplantation in B-cell non-Hodgkin's lymphoma: very low treatment-related mortality in 100 patients in sensitive relapse." Journal of Clinical Oncology 8, no. 5 (1990): 784–91. http://dx.doi.org/10.1200/jco.1990.8.5.784.

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One hundred patients with B-cell non-Hodgkin's lymphoma (NHL) in sensitive relapse or incomplete first remission underwent high-dose chemoradiotherapy and anti-B-cell monoclonal antibody (MAb)-treated autologous bone marrow transplantation (ABMT). These patients demonstrated good performance status with a Karnofsky score of 80% or greater. The majority of these patients had one or more adverse prognostic features including a failure to achieve a complete remission (CR) with conventional combination chemotherapy (37 patients), bone marrow infiltration (69 patients), a history of extranodal dise

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Meena, Sanjay Kumar, Naveen Goyal, Devendra Tetarwal, and Bharat Sharma. "Role of bone marrow infiltration in management of delayed union of long bones fracture." International Journal of Research in Orthopaedics 6, no. 5 (2020): 968. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20203716.

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<p class="abstract"><strong>Background:</strong> Usually delayed union of fracture long bones are managed by putting a bone graft at fracture site , but bone grafting have donor site complication like scar, infection ,hernia ,gait disturbance , cosmetic problem, as well as recipient site complication like soft tissue trauma , de-vascularisation of fracture fragment. Bone marrow infiltration is a minimally invasive method done percutaneously. It is easy, safe procedure with no associated complications that may occur in bone grafting.</p><p class="abstract"><stro

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Siddiki, Md Shahriar, Nur Alam, Istiuqe Ahmed, et al. "Microangiopathic Hemolytic Anemia: A Rare Clue to Diagnose Bone Marrow Metastatic Gastric Adenocarcinoma." Journal of Medicine 20, no. 2 (2019): 102–5. http://dx.doi.org/10.3329/jom.v20i2.42012.

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Microangiopathic Hemolytic Anemia (MAHA) is a hematological condition which is very rare for the primary presentation of a gastric adenocarcinoma with bone marrow metastases. When it emerges as initial findings in a previously undetected case of malignancy, the diagnosis is often missed and results in inappropriate management. Carcinoma stomach associated with MAHA is generally having fulminant course. This is a case report of a 30-year-old male who presented with widespread bone marrow infiltration along with Coomb’s negative haemolytic anemia, thrombocytopenia and schistocytes in peripheral

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Mensen, Angela, Korinna Jöhrens, Ioannis Anagnostopoulos, et al. "Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT." Blood 124, no. 6 (2014): 963–72. http://dx.doi.org/10.1182/blood-2013-11-539031.

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Key Points Donor T-cell infiltration of the bone marrow is associated with impaired B-cell immunity after allogeneic HSCT. Quantification of κ-deleting recombination excision circles as a biomarker for bone marrow B-cell output in different clinical episodes.

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45

Buraid, Hasan A., Abdulkareem M. Jaafar, and Rana Z. Naji. "Immunohistochemical study of bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors." Journal of the Faculty of Medicine Baghdad 56, no. 2 (2014): 195–99. http://dx.doi.org/10.32007/jfacmedbagdad.562468.

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Background: In recent years, bone marrow angiogenesis was reported to be involved in the pathogenesis and progression of certain hematological malignancies like multiple myeloma, leukemias, and lymphomas. Recent studies have suggested that bone marrow angiogenesis plays an important role in the pathogenesis and prognosis of multiple myeloma.Objectives: at the present study, bone marrow angiogenesis in multiple myeloma was examined using immunohistochemical staining for CD34, and correlated with various pathological and clinical parameters.Patients and methods: This is a retrospective study; wh

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Carulli, Giovanni, Sara Galimberti, Giuseppina Bianchi, et al. "Comparison of Bone Marrow Biopsy, Flow Cytometry and PCR Assays To Detect Bone Marrow Involvement in B-Cell Non-Hodgkin Lymphomas." Blood 106, no. 11 (2005): 4670. http://dx.doi.org/10.1182/blood.v106.11.4670.4670.

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Abstract Bone marrow biopsy, (BMB) is essential to detect bone marrow (BM) infiltration in B-cell non-Hodgkin lymphomas (NHLs). Flow cytometry (FC) and PCR for clonal IgH rearrangement are considered as ancillary methods, but there is increasing evidence for their clinical usefulness. Observations dealing with combined use of the three methods still are lacking. Thus we carried out a retrospective study about the usefulness of an integrated approach to detect BM infiltration in NHLs. 193 patients suffering from NHLs (79 at presentation, 114 after chemotherapy alone or with: Rituximab, Campath-

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Nakajima, Yuki, Shin Fujisawa, Chika Nigauri, et al. "Identification of Bone Marrow Involvement of FL: Comparison of PET-CT and Bone Marrow Biopsy." Blood 128, no. 22 (2016): 2970. http://dx.doi.org/10.1182/blood.v128.22.2970.2970.

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Abstract Introduction In malignant lymphoma, bone marrow involvement is considered as clinical stage IV which adversely affects International Prognostic Index resulting in poor outcome. Detecting bone marrow lesion is therefore important in staging of newly diagnosed malignant lymphoma. Bone marrow biopsy (BMB) of unilateral or bilateral iliac crest has been a classical method to detect bone marrow infiltration. However, BMB in rare instance, induce some complications including excessive bleeding, infections, or lasting pain. Recently, positron emission tomography combined with computed tomogr

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Yamamura, Masao. "Structural Changes in Jaw Bone Marrow After Hemorrhagic Infiltration." JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN 61, no. 2 (1994): 207–20. http://dx.doi.org/10.5357/koubyou.61.207.

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Maywald, Ole, Georgia Metzgeroth, Claudia Schoch, et al. "Alveolar rhabdomyosarcoma with bone marrow infiltration mimicking haematological neoplasia." British Journal of Haematology 119, no. 3 (2002): 583. http://dx.doi.org/10.1046/j.1365-2141.2002.03860.x.

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Villarrubia, Jesús, Ricardo F. de Misa, Luis Escribano, Carmen Bellas, and Jose Luis Velasco. "Amelanotic Bone Marrow Infiltration Secondary to Pigmented Malignant Melanoma." Journal of Dermatology 22, no. 8 (1995): 620–22. http://dx.doi.org/10.1111/j.1346-8138.1995.tb03885.x.

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