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Dissertations / Theses on the topic 'Bone morphogenetic proteins'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Thomas, Nicole. "Bone morphogenetic proteins and hair and wool follicle morphogenesis." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09pht4592.pdf.

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Bibliography: leaves 119-135. A thesis which describes a study to establish the relative roles that the bone morphogenetic proteins BMP-2 and BMP-4 play in initiating hair and derived wool follicles by first establishing their expression patterns by in situ hybridisation and then manipulating them in vitro.

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2

Christison, Joseph George. "The role of bone morphogenetic proteins in otic specification /." Connect to title online (ProQuest), 2008. http://proquest.umi.com/pqdweb?did=1616787971&sid=1&Fmt=2&clientId=11238&RQT=309&VName=PQD.

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Thesis (Ph. D.)--University of Oregon, 2008.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 43-47). Also available online in ProQuest, free to University of Oregon users.

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3

Yin, Huiran. "Expression, purification, and characterization of the extracellular domain of human BMPR-II in solution : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1436373301&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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4

Qualtrough, John David. "Bone morphogenetic proteins in human embryonal carcinoma cells." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311810.

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5

Mowbray, Catriona. "Bone morphogenetic proteins and zebrafish inner ear development." Thesis, University of Sheffield, 2002. http://etheses.whiterose.ac.uk/14716/.

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This thesis describes the mRNA expression patterns of the Bone Morphogenetic Proteins (BMPs), downstream members of the BMP signal pathway, BMP antagonists and candidate target genes in the developing inner ear of wild type zebrafish. The crista Bmp expression pattern is conserved between four vertebrate species. However, unlike in chick, mouse and Xenopus laevis none of the hmps examined are macula markers in zebrafish. This thesis identifies sources of Bmp signalling (the cristae, the endolymphatic duct (ED) and the semicircular canals (SCC)) and possible sites of Bmp action (the cristae, po

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6

Young, Julia, and n/a. "Bone morphogenetic proteins are involved in controlling mammalian fertility." University of Otago. Department of Biochemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20090112.122706.

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Transforming growth factor beta (TGFβ) superfamily members are involved in controlling mammalian fertility. The largest subset of the TGFβ superfamily are the bone morphogenetic proteins (BMP). BMP ligands signal through the type I and II BMP receptors and utilise the Smads1/5/8 phosphorylation cascade to control gene expression in the cell nucleus. Although BMPs act through the same pathway, they have the ability to activate unique sets of genes dependant on the identity of the ligand. In this study, HEK293T cells were challenged with BMP ligands for four hours and gene expression profiles we

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7

Mace, Peter, and n/a. "Biochemistry of ovine bone and morphogenetic proteins and receptors." University of Otago. Department of Biochemistry, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070508.133410.

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The transforming growth factor (TGF)-β superfamily mediates a wide range of differentiation and developmental processes across many genera. GDF9 and BMP15 are expressed exclusively in the mammalian ovary and are the only TGF-β ligands that lack the conserved cysteine residue used for dimerisation. As a platform for studying the interactions between GDF9 and BMP15 and their receptors, BMPRII and BMPRIb, a variety of strategies were attempted to produce soluble and active proteins from recombinant systems. Both ligands and receptors showed a tendency to form insoluble aggregates when expressed i

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8

Wise, Sarah B. "Bone morphogenetic proteins in teleost tooth development and evolution." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3256386.

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9

Dootson, Gina Elizabeth. "Pro-osteogenic effects of follistatin on bone morphogenetic proteins." Thesis, University of York, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437559.

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10

Al-Hourani, Kinda. "Antiviral functions of bone morphogenetic proteins and the activins." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:579bda45-7f98-447d-b2d7-0565a00d8995.

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Previous work in the Drakesmith lab has revealed a novel anti-HCV function of bone morphogenetic protein 6 (BMP6), a TGFβ-superfamily cytokine unrelated to type I IFN. Recombinant BMP6 is antiviral against both replication-competent HCV and a full-length genomic replicon model. Data presented in this thesis demonstrate that an anti-HCV effect extends to multiple BMPs and segregates with ability to ligate the type I BMP receptor. Canonically, the type I BMP receptor signals intracellularly via phosphorylation of SMAD1/5/8 transcription factors. Prior work in the lab shows that BMP6 exerts both

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11

Ahmed, Takiya Janice. "The role of bone morphogenetic proteins in otic specification /." Connect to title online (Scholars' Bank) Connect to title online (ProQuest), 2008. http://hdl.handle.net/1794/8447.

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Thesis (Ph. D.)--University of Oregon, 2008.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 195-204). Also available online in ProQuest, free to University of Oregon users.

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12

Liu, Jin. "Increased CKIP-1 suppresses Smad-dependent BMP signaling to inhibit bone formation during aging." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/327.

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Emerging evidence indicates that the dysregulation of protein ubiquitination plays a crucial role in aging-associated diseases. Smad-dependent canonical BMP signaling pathway is indispensable for osteoblastic bone formation, which could be disrupted by the ubiquitination and subsequent proteasomal degradation of Smad1/5, the key molecules for BMP signaling transduction. However, whether the dysregulation of Smad1/5 ubiquitination and disrupted BMP signaling pathway are responsible for the age-related bone formation reduction is still underexplored. Casein kinase-2 interacting protein-1 (CKIP-1

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13

Weber, Markus. "Bone Morphogenetic Proteins (BMP) in der Embryonalentwicklung von Tribolium castaneum." Diss., [S.l.] : [s.n.], 2006. http://edoc.ub.uni-muenchen.de/archive/00006560.

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14

Din, Sarah. "The Protective Role of Bone Morphogenetic Proteins in Pulmonary Artery." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486283.

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Familial primary pulmonary arterial hypertension (FPAH) is associated with mutations in bone morphogenetic protein receptor II (BMPRII). The role of this mutation in vascular tone and structural remodelling in PAH is unknown. The aim of this thesis was.to determine the ability of BMPRII ligands to modulate the ET-1 system, which has been implicated in the p'athogenesis of FPAH. BMP2, BMP4 and BMP? were examined for their effects on ET-1 release by cultured pulmonary artery smooth muscle cells (PASMC). BMP? (100ng/ml) significantly reduced cytokine-induced ET-1 release. BMP2 and BMP4 had no eff

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15

Al-Samerria, Sarmed. "The role of bone morphogenetic proteins (BMPs) in ovarian function." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/1567.

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Bone morphogenetic proteins (BMPs) have been reported to involve in the ovarian folliculogenesis through interacting with gonadotropin hormones. However, the mechanism of interaction is not clearly understood. The aim of the current study was to demonstrate the mechanism of interaction between BMPs and gonadotropins using different technical approaches. The outcomes of the current study demonstrate that BMPs involves directly and indirectly in regulating follicle development which opens an interesting opportunity to improve fertility and enhance reproductive life.

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Ramage, Samuel Cowan. "The role of secreted phosphoprotein-24 in osteoblast differentiation and matrix mineralization /." Available online after August 19, 2013, 2007. http://hdl.handle.net/10156/2291.

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17

Yong, Tseh-Hwan. "Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33405.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2005.<br>"June 2005."<br>Includes bibliographical references.<br>Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems of limited availability and surgical morbidity. The use of allografts obtained from donors is also not desirable due to the risks of disease transmission and the costs of maintaining bone banks. The ideal solution

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18

Ye, Lin. "Bone morphogenetic proteins and their receptors in the development of bone metastasis in prostate cancer." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55718/.

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Bone morphogenetic proteins (BMPs) are key factors in bone formation. Selective BMPs have been implicated in the progression and in particular the bone metastasis of prostate cancer. However, the exact role of the BMPs and the signaling pathways initiated by BMP in cancer including prostate cancer are poorly understood. This study aims to investigate the role of a panel of newly discovered BMPs in prostate cancer and the possible signal transduction pathways in prostate cancer. In the current study, we examined the expression of certain BMPs, the BMP receptors and putative intracellular signal

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19

Song, Hannah. "Endothelial bone morphogenic protein 4 and bone morphogenic protein receptor II expression in inflammation and atherosclerosis." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/28258.

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Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Hanjoong Jo; Committee Member: Ajit P. Yoganathan; Committee Member: Andrew P. Kowalczyk; Committee Member: David G. Harrison; Committee Member: Kathy K. Griendling

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20

Chan, Wai-long, and 陳慧朗. "The protective role of bone morphogenetic protein-7 against mesangial cell injury in IgA nephropathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290872.

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21

Brown, Elaine Hilary. "Chemical modification of 5-aminolevulinic acid for improved photodynamic therapy." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14513.

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5-Aminolevulinic acid (ALA), one of the body's naturally occurring molecules in the biosynthetic pathway to haem, is being used in Photodynamic Therapy (PDT), a new approach to the treatment of cancer. It is a highly reactive molecule, which, upon standing in solution, dimerises to give 2,5-di-(beta-carboxyethyl) pyrazine. This reaction, and other similar ones, have been studied in some detail as it remains a major problem in the clinic, lowering the dose of active drug being administered and forming a molecule of which the toxicology is not known. The initial product of dimerisation is a dihy

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Chan, Wai-long. "The protective role of bone morphogenetic protein-7 against mesangial cell injury in IgA nephropathy." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290872.

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23

Bokobza, Sivan. "The role of bone morphogenetic proteins and their signalling in human cancers." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55464/.

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Both endogenous and exogenous GDF-9 led to a promotion in prostate cancer cell adhesion, invasion, motility, and growth. GDF-9 mediated growth promotion was shown to correlate with an increase in cell cycle progression via up-regulation of Cyclin D1, and protection from apoptosis in a Smad-independent manner. Furthermore, GDF-9 associated cell adhesion, motility, and invasion was shown to involve FAK, paxillin, and Rho-ROCK signalling, as well as EMT and its associated inducers. These effects promote the aggressiveness of PC-3 cells, aiding in their progression and possibly metastasis. These r

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24

Hornstein, Alexandra Marielisa [Verfasser]. "Einfluss bestimmter bone morphogenetic proteins auf die endotheliale Permeabilität / Alexandra Marielisa Hornstein." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1090877927/34.

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25

Cannon, John Edward. "The role of bone morphogenetic protein signalling in zebrafish vascular development." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609960.

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26

Peirce, Vivian Julia. "Regulation of adipose tissue function by bone morphogenic protein 8b." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709428.

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27

Phan, Tuan (Tony). "Functional characterisation of an osteoclast-derived osteoblastic factor (ODOF)." University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0028.

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[Truncated abstract] Bone is a living tissue and is maintained by the coordinate action of osteoblasts and osteoclasts. The intercellular communication between these two cells is the quintessential mechanism in bone remodelling. Unfortunately, the importance of this interaction is often neglected and its significance is only realised when disruption of this “cross-talk” results in debilitating bone diseases. Additionally, the number of known proteins that are involved in this “cross-talk”, especially those that are osteoclast-derived, and act specifically on osteoblasts, is limited. This discr

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Li, Ruixi, and 李瑞曦. "Anti-inflammatory role of bone morphogenetic protein 7 in the diabetic kidney." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/211143.

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Diabetic nephropathy (DN) has become the leading cause of end stage renal disease (ESRD) in developed countries, in which over 90% of the diabetes burden is type 2 in origin. Despite the ever advancing knowledge in the pathogenetic mechanisms of DN, a specific treatment is still lacking and management using contemporary approaches or exploiting newly described therapeutic targets are largely unrewarding. BMP-7 has been reported to confer renal protective effects in acute and chronic kidney disease models, but its potential utility in type 2 diabetic nephropathy remains unknown. In this work, t

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Böhler, Nina. "Auswirkungen von Gewichtsreduktion und einem kontrollierten Trainingsprogramm auf die Serumkonzentration der Bone morphogenetic proteins (BMPs) -2 und -4 bei Patienten mit Typ 2 Diabetes." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-149795.

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Adipositas und Typ-2-Diabetes sind häufige Erkrankungen des Stoffwechsels. Zur Basistherapie der Adipositas und des Typ-2-Diabetes gehören eine gesunde Ernährungs- weise und die Erhöhung der körperlichen Aktivität unter anderem mit dem Ziel der Gewichtsreduktion. Vermehrte Bewegung führt neben der Verbesserung der körperlichen Leistungsfähigkeit zur Fettmassenreduktion, Verbesserungen der Hyperglykämie, Lipo- proteinstoffwechsels und des Adipokinprofils. Bone morphogenetic proteins (BMPs) werden im Fettgewebe produziert und spielen eine wichtige Rolle in der Adipogenese und Transdifferenzierun

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30

Hoang, Quyen Quoc Yang Daniel. "Crystal structure and hydroxyapatite binding of porcine osteocalcin /." *McMaster only, 2003.

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31

Brown, Monica Anne. "Structural and functional analysis of bone morphogenetic proteins crystal structure of bone morphogenetic protein-9, binding studies with pro-domain and receptors, and mutational studies in Drosophila decapentaplegic /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3304428.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 18, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 62-72).

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Zhou, Lixiong, and 周立雄. "Differential action of bone morphogenetic protein BMP-2 and BMP-7 on nucleus pulposus cells of intervertebral disc." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209509.

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Low back pain (LBP) is associated with intervertebral disc (IVD) degeneration and exerts enormous socioeconomic burdens on the society. The nucleus pulposus (NP) is the structural and functional core of the IVD, and plays vital roles in its homeostasis. Although the etiology of IVD degeneration is not fully understood, the cellular changes of the NP have been proposed to be associated with degeneration. Conventional management for IVD degeneration primarily targets to relieve LBP and other symptoms without restoring or preserving disc function. Novel therapeutic strategies have emerged with an

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Wardle, Fiona Claire. "Regulation of the BMP signalling pathway by BMP-1 related metalloproteases." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287477.

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34

Anantharam, Andrea Brenner. "The role of BMP signaling in the segmentation of the urinary tract /." Access full-text from WCMC, 2007. http://proquest.umi.com/pqdweb?did=1490074011&sid=13&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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35

Campisi, Paolo. "Characterization of the expression of bone morphogenetic proteins during distraction osteogenesis of the mandible." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32980.

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Distraction osteogenesis is a form of in vivo tissue engineering used to lengthen bone. Bone morphogenetic proteins (BMPs) are known mediators of bone formation during the distraction of enchondral bones. Their role in the distraction of membranous bones remains unknown. A rabbit model was used to characterize the expression of BMP-2, 4 and 7 during mandibular distraction osteogenesis. Fourteen animals were subjected to a defined distraction protocol. At weekly intervals, two rabbits were sacrificed and the generate bone harvested for radiographic, bone densitometric, histologic and immunohist

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36

Fuller, Molly Lynn. "The Role of Bone Morphogenetic Proteins in Reactive Gliosis after Demyelinating Spinal Cord Lesions." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1183990990.

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37

Kapanen, A. (Anita). "Biocompatibility of orthopaedic implants on bone forming cells." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514266064.

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Abstract Reindeer antler was studied for its possible use as a bone implant material. A molecular biological study showed that antler contains a growth factor promoting bone formation. Ectopic bone formation assay showed that antler is not an equally effective inducer as allogenic material. Ectopic bone formation assay was optimised for biocompatibility studies of orthopaedic NiTi implants. Ti-6Al-4V and stainless steel were used as reference materials. The assay showed differences in bone mineral densities, with superior qualities in NiTi. The rate of endochondral ossification varie

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Zhao, Xiaoli, and 赵晓丽. "BMP2 gene delivery mediated by chitosan-ss-PEI non-viral vector and investigation of BMP2 signaling regulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47246078.

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Osteoporotic fractures are still the major health concerns in many developed societies especially when the incidence of that tremendously increased with the aging population. However, the outcomes of osteoporotic fracture treatment have not been entirely satisfactory due to the poor quality of bone substance. Inspiringly, bone morphogenetic protein 2 (BMP2) with the ability to accelerate bone formation showed advantages over the conventional treatment. The only problem needed to overcome is its short half-life which resulted in the requirement of readministration and extremely high cos

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Lewis, Christopher John. "The role of bone morphogenetic protein signalling in the control of skin repair after wounding : cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/7337.

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Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) coordinate tissue development and postnatal remodelling by regulating proliferation, differentiation and apoptosis. However, their role in wound healing remains unclear. To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) or the BMP antagonist Noggin (K14-Noggin) were utilised, together with human and mouse ex vivo wound healing models and in vitro keratinocyte culture. In wild-type mice, transcripts for Bmpr-1A, Bmpr-II, Bmp ligands and Smad proteins were decreased following tissue injury, whilst Bmpr-1B expression w

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Lewis, Christopher J. "The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/7337.

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Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) coordinate tissue development and postnatal remodelling by regulating proliferation, differentiation and apoptosis. However, their role in wound healing remains unclear. To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) or the BMP antagonist Noggin (K14-Noggin) were utilised, together with human and mouse ex vivo wound healing models and in vitro keratinocyte culture. In wild-type mice, transcripts for Bmpr-1A, Bmpr-II, Bmp ligands and Smad proteins were decreased following tissue injury, whilst Bmpr-1B expression

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Chang, Hsun-Ming. "The roles of oocyte- and theca cell-derived bone morphogenetic proteins in human granulosa cells." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50685.

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Exerting a broad range of biological effects in various tissues, bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor β superfamily. Accumulating evidence indicates that ovarian BMPs are critical regulators of ovarian function and play important roles in the female reproductive system. Mutual communication between oocytes and the surrounding somatic cells is mandatory for normal follicle development, as these locally expressed growth factors function mainly as paracrine/autocrine effectors in granulosa cells. Previous studies

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Harrington, A. E. "Structural and functional analyses of follistatin, a secreted antagonist of activins and bone morphogenetic proteins." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603738.

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Follistatin is a secreted glycoprotein that binds to and prevents the activation of cell surface receptors by growth factors of the TGF-β superfamily. It is composed of four disulfide-rich domains, three of which adopt the follistatin (FS) domain fold. A region in the Fs1 domain, rich in basic residues, is responsible for the protein’s interaction with heparin sulfates (HS) in the extracellular milieu. The nature of this association is investigated in this work by various biophysical studies, which, <i>inter alia</i>, demonstrate that HS and analogues with greater than six disaccharide units

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Li, Jin. "Bone morphogenetic proteins and their co-receptor, repulsive guidance molecules, signalling pathways in human cancers." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55075/.

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RGMs (repulsive guidance molecules) are a group of recently identified GPI (glycosylphosphatidylinositol)-linked cell-membrane-associated proteins, comprising three family members, which have been implicated in BMPs (Bone morphogenetic proteins) signalling. BMPs have been shown to play profound roles in bone metastases from breast cancer and prostate cancer. This study aims to investigate the implication of RGMs in prostate cancer and breast cancer and their role in coordinating signal transduction by BMPs during disease progression of cancer. The aberrant expression of RGMs was found in breas

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Faure, Marie-Odile. "Bone morphogenetic proteins (BMPs) : new modulators of the follicle stimulating hormone (FSH) synthesis and release." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/30189.

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To extend our knowledge on FSH synthesis regulation, we investigated the potential role of BMPs in the ewe pituitary. The two types of BMP receptors (BMPR-IA and BMPR-II) co-localised with gonadotrope cells and their ligands (BMP-2, BMP-4, BMP-7 and GDF-9) mRNAs were detected in the pituitary suggesting a paracrine action of BMPs. BMPR-IB \was not detected on gonadotropes. Interestingly, in three breeds of ewes, BMP-4 as well as BMP-6, BMP-15 and GDF-9 inhibited specifically the FSH synthesis and release, but not the LH production from ewe pituitary cells. Moreover, BMP-4 antagonized the stim

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Luvizuto, Eloá Rodrigues [UNESP]. "O efeito da BMP-2 sobre as propriedades osteocondutoras do beta-tricálcio fosfato em defeitos de calvária de ratos." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/101204.

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Made available in DSpace on 2014-06-11T19:31:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-05-27Bitstream added on 2014-06-13T19:41:06Z : No. of bitstreams: 1 luvizuto_er_dr_araca.pdf: 1092204 bytes, checksum: 1e6344b6cf18e7d173b8b90d3efcb6bc (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A neoformação óssea em defeitos críticos em calvária de ratos depende fortemente das propriedades osteocondutoras dos enxertos e biomateriais. Ainda é controverso se os biomateriais podem substituir

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Schütte, Andrea. "Autoantibodies against growth factors and their receptors in fracture healing." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17656.

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Die Knochenregeneration während der Frakturheilung beinhaltet das Zusammenspiel von Wachstumsfaktoren. In einigen Patienten kommt es zu einer verzögerten oder unvollständigen Heilung. Die Gründe hierfür sind bisher nicht komplett verstanden. Neutralisierende Autoantikörper (aAB) gegen Wachstumsfaktoren oder deren Rezeptoren könnten den Heilungsprozess verzögern und potentiell beeinträchtigen In dieser Arbeit wurden 265 Frakturpatienten analysiert. Autoantikörper gegen IGF1 Rezeptor, Insulin Rezeptor, BMP7, BMP2, IGF1 und (Pro)Insulin wurden in den Seren dieser Frakturpatienten gemessen. In

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Star, Gregory. "The effects of bone morphogenic proteins and transforming growth factor [beta] on in-vitro endothelin-1 production by human pulmonary microvascular endothelial cells /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111942.

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Introduction: Idiopathic Pulmonary arteriole hypertension (IPAH) is a rare but severely debilitating disease that strikes women to men at a ratio of 3:1. Endothelial cell (EC) dysfunction is a hallmark of the disease. This includes rapid growth of the ECs until the occlusion of the vasculature as well as decreased blood levels of vasodilators. Markedly increased levels of endothelin-1, a potent vasoconstrictor and smooth muscle mitogen, have been noted in IPAH patients.<br>Recently mutations in the bone morphogenic protein receptor type II (BMPRII) have been linked to the disease. Interestingl

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Boulet, Nathalie. "Rôles des Bone Morphogenetic Proteins dans la conversion adipocytaire et le développement du tissu adipeux humain." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30187/document.

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Les adipocytes (cellules spécialisées dans le stockage des graisses) sont formés à partir de cellules immatures appelées cellules progénitrices lors du processus d'adipogenèse. Chez l'homme, les différentes étapes de ce processus sont mal connues ainsi que les signaux qui le régulent. La première partie de mon travail de thèse a eu pour but de caractériser la cellule intermédiaire entre la cellule progénitrice et l'adipocyte : le préadipocyte. La deuxième partie a consisté à évaluer le rôle des protéines morphogénétiques de l'os (ou BMP), des inducteurs de l'adipogenèse décrits chez la souris,

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49

Zachos, Terri A. "Gene-augmented mesenchymal stem cells in bone repair." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1146076285.

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Whittle, Andrew John. "A role for bone morphogenetic protein 8b in brown adipose tissue thermogenesis and energy homeostasis." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609416.

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