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Dissertations / Theses on the topic 'Bone resorption'

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1

Pierce, Angela Mary. "Cellular mechanisms in bone and tooth resorption morphological studies in rats and monkeys /." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1988. http://books.google.com/books?id=usBpAAAAMAAJ.

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2

Heath, J. K. "Studies on cellular interactions in bone resorption." Thesis, Anglia Ruskin University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354876.

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3

McCauley, Laurie Kay. "Cellular mechanisms of lymphocyte-mediated bone resorption /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487759055156174.

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4

Stutzer, Andre. "Retinoid induced bone resorption, model and application /." [S.l.] : [s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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5

Ransjö, Maria. "Regulation of bone resorption by the adenylate cyclase-cyclic AMP system a biochemical study on mouse calvarial bones and isolated bone cells /." Umeå, Sweden : University of Umeå, 1988. http://catalog.hathitrust.org/api/volumes/oclc/18171035.html.

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6

Bernhold, Brechter Anna. "Kinins : important regulators in inflammation induced bone resorption." Doctoral thesis, Umeå : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-959.

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7

Moroz, Adam. "Reduced order modelling of bone resorption and formation." Thesis, De Montfort University, 2011. http://hdl.handle.net/2086/5409.

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The bone remodelling process, performed by the Bone Multicellular Unit (BMU) is a key multi-hierarchically regulated process, which provides and supports various functionality of bone tissue. It is also plays a critical role in bone disorders, as well as bone tissue healing following damage. Improved modelling of bone turnover processes could play a significant role in helping to understand the underlying cause of bone disorders and thus develop more effective treatment methods. Moreover, despite extensive research in the field of bone tissue engineering, bonescaffold development is still very
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8

Ljunggren, Östen. "Involvement of bradykinin in inflammation induced bone resorption." Umeå : University of Umeå, 1991. http://catalog.hathitrust.org/api/volumes/oclc/24493228.html.

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9

Korhonen, T. (Tommi). "Bone flap survival and resorption after autologous cranioplasty." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526222530.

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Abstract This thesis evaluated the factors affecting bone flap survival and bone flap resorption after primary cranial reparation surgery, cranioplasty, conducted to repair a cranial bone defect with an autologous cryopreserved bone flap. Emphasis is put on the predictors, progression, and definition of an important yet poorly understood postoperative complication, bone flap resorption. Study I assessed the rates and predictors of bone flap removal and bone flap resorption in a Finnish retrospective multicentre setting. 40% of patients developed complications of whom half required bone flap re
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10

Neale, Susan Dorothy. "The role of macrophages in pathological bone resorption /." Title page, table of contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09MSM/09msmn348.pdf.

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11

Dreyer, Craig William. "Clast cell activity in a model of aseptic root resorption." Title page, table of contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phd778.pdf.

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12

Wang, Ee Jen Wilson. "The effects of infection-related factors on bone resorption." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365291.

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13

Martin, Joanne. "In vitro osteoclast resorption of calcium phosphate bone substitutes." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695663.

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Resorption of calcium phosphate (CaP) biomaterials is traditionally assessed using an osteoclast (QC) resorption assay where resorption pits formed on the CaP surface are analysed by microscopy techniques and quantified on the basis of pit number, pit area or pit volume. Pit area measurements (20) have become common practice when assessing CaP biomaterial resorption in vitro. Apart from the time consuming nature of pit area analysis techniques it is not a precise indicator of resorption; variations in pit depth are not taken into consideration and it is unsuitable for use on porous materials w
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14

Reddi, Durga. "Interactions of porphyromonas gingivalis with bone marrow cells : implications on mediators of bone resorption." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/3161.

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Periodontitis is a multi-factorial disease characterised by the loss of connective tissue and underlying alveolar bone leading to the loss of teeth. Porphyromonas gingivalis (P. gingivalis) is a gram-negative black pigmented anaerobe associated with chronic periodontitis. Porphyromonas gingivalis possesses a range of virulence factors including gingipains, lipopolysaccharide (LPS) and fimbriae. Receptor activator of nuclear factor-κB ligand (RANKL) induces bone resorption whilst osteoprotegerin (OPG) blocks this process by binding to RANKL and acting as a decoy receptor. Cyclooxygenase-2 (COX-
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15

Negus, Charles Hugh. "Three dimensional dynamic hypoelastic remodeling in the proximal femur /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208622.

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16

Hou, Peng. "Matrix metalloproteinases in the osteoclast, with special emphasis on the molecular cloning and the functional role of matrix metalloproteinase-12." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287350.

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17

Al-Dehaimi, Abdulwahed. "Evaluation of galactosyl hydroxylysine as a marker of bone resorption." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364314.

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18

Last, Keith Sydney. "Glycosaminoglycans in gingival crevicular fluid in relation to bone resorption." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317010.

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19

Davey, Tamara. "Functional characterisation of a novel osteoclast-derived factor." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0219.

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[Truncated abstract] Intracellular communication between osteoclasts and osteoblasts is imperative to maintain bone integrity. A myriad of molecules are responsible for regulating osteoblast and osteoclast activity. In particular, it is well documented that osteoblast-derived factors are crucial in directly controlling osteoclast formation and function. Since bone formation is coupled to bone resorption, it would be expected that osteoclasts also have some role in regulating the growth and function of osteoblast cells. However, despite extensive research upon osteoclast and osteoblast biology,
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20

Lean, Jennifer Maree. "Mechanical stimulation of bone formation in the rat." Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263682.

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21

Stewart, Charlotte. "Structure activity relationships of bisphosphonate analogues." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=128207.

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The nitrogen-containing bisphosphonates (NBPs) are the most widely used treatment for diseases involving excessive osteoclastic bone resorption, such as osteoporosis. The clinical efficacy of NBPs is due in large part to their affinity for bone mineral, but it has been suggested that lowering affinity may have benefits due to altered distribution and duration of action possibly allowing direct anti-tumour effects. In addition, the phosphonocarboxylate (PC) analogues inhibit prenylation more selectively through a different enzyme target, Rab geranylgeranyl transferase (RGGT), which may offer ad
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22

Frith, Julie C. "Studies into the mechanism of action of clodronate." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299577.

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23

Nagao, Jiro. "Computer-Aided Diagnosis of Alveolar Bone Resorption using Dental 3DCT Images." INTELLIGENT MEDIA INTEGRATION NAGOYA UNIVERSITY / COE, 2005. http://hdl.handle.net/2237/10393.

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24

Mansfield, Ian David. "The synthesis of novel agents which inhibit tumour-stimulated bone resorption." Thesis, Loughborough University, 1999. https://dspace.lboro.ac.uk/2134/27412.

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A range of conjugates which focused on bisphosphonates as delivery molecules and on oestrogens as resorption inhibitors were synthesised. Various moieties were coupled through an ester linkage to bisphosphonates which were then converted to the corresponding bisphosphonic acids. This ester linkage was considered to be readily hydrolysable under normal physiological conditions.
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25

Morgan, Hayley Michaela. "Mechanisms involved in breast tumour cell mediated bone resorption in vitro." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393664.

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26

Ren, Zhongyuan. "Small molecules regulated bone resorption and enzyme activity in osseous cells." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10291/document.

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La Cathepsine K est parmi la plus efficace des collagénases de mammifère pour cliver la triple hélice de collagène de type-1. Nous avons développé une série d'azanitriles, (CKI-8 and CKI-13) inhibiteurs de cathepsine K. CKI-8 (un isomère de CKI-13) et CKI-13 ne sont pas toxiques sur les osteoblastes Saos-2 et les cellules RAW 264.7 jusqu' à une concentration de 1000 nM, tandis qu'ils ne le sont pas jusqu'à une concentration de 100 nM sur les osteoclastes. CKI-8 n'affecte pas l'activité de la phosphatase alkaline ainsi que la minéralisation induite par les Saos-2 et par les osteoblastes primair
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27

Miao, Dengshun. "Studies on the actions of bone anabolic drugs in vivo and in vitro." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300362.

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28

Cvijic, Gojko 1971. "Avaliação radiográfica do nível ósseo em implantes com diferentes tratamentos de superfície, inseridos na área enxertada." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289068.

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Orientador: Frederico Andrade e Silva<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-22T06:55:09Z (GMT). No. of bitstreams: 1 Cvijic_Gojko_D.pdf: 2099298 bytes, checksum: abafee052c159ac120d8c1fc520d05e2 (MD5) Previous issue date: 2013<br>Resumo: O objetivo deste estudo foi comparar o nível de reabsorção óssea em implantes com superfícies física e quimicamente tratadas, carregados com coroas unitárias, inseridos em osso previamente enxertado. Foram avaliadas as imagens digitalizadas das radiografias peria
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29

Li, Jian. "Spontaneous correction of fracture deformity : a study in the rat /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-119-9/.

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30

Nordahl, Joakim. "Matrix resorption in endochondral bone growth : ultrastructural studies, with special attention to the chondroclast /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4513-6/.

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31

Persson, Emma. "The Neuropeptide VIP and the IL-6 family of cytokines in bone : effects on bone resorption, cytokine expression and receptor signalling in osteoblasts and bone marrow stromal cells /." Doctoral thesis, Umeå : Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-606.

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32

Weekes, David Michael. "Lanthanum complexes as therapeutic agents for the treatment of bone resorption disorders." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58567.

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Lanthanum naturally targets and binds skeletal tissue in living systems, wherein it has the potential to treat bone resorption disorders by invoking a biological response that counteracts an imbalanced bone remodeling cycle. Because lanthanum is very poorly absorbed, the key to realizing this potential is through rational chelator design, and in this regard, a number of lanthanum complexes have been designed, synthesized, and tested in an effort to develop an orally-active drug. Previously, past group members Dr. Cheri Barta and Dr. Yasmin Mawani had identified tris-(1,2-dimetyl-3-oxypyridin-4
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33

Dossa, Tanya. "Osteoclast-specific inactivation of the Integrin-Linked Kinase (ILK) inhibits bone resorption." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99336.

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Bone resorption requires the adhesion of osteoclasts to extracellular matrix (ECM) components, a process mediated by the alphavbeta 3 integrin. Following engagement with the ECM, integrin receptors signal via multiple downstream effectors, including the Integrin-Linked Kinase (ILK). In order to characterize the physiological role of ILK in bone resorption, we generated mice with an osteoclast-specific ILK gene ablation. Mice with one inactivated ILK allele (ILK+/-) were mated with TRAP-Cre transgenic mice. Progeny from this cross (TRAP-Cre;ILK+/-) was bred to mice homozygous for a floxed ILK a
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34

Althnaian, Thnaian Ali. "Factors that regulate osteoclast formation and bone resorption in regenerating deer antlers." Thesis, Royal Veterinary College (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439832.

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35

Tkachenko, Evgeniy. "Measures of Individual Resorption Cavities in Three-Dimensional Images in Cancellous Bone." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1301413780.

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36

Chaplais, Elodie. "The Adibox Study: Adiposity and Bone Metabolism: Effects of Exercise-induced Weight Loss in Adolescents with Obesity." Thesis, Australian Catholic University, 2017. https://acuresearchbank.acu.edu.au/download/53f5d8a6c9f7442b4ab4a69db7896bd9e81a4d0daa6c4ceb4223556dcd7524e6/27301614/CHAPLAIS_2017_THESIS.pdf.

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Introduction: This program of research targeted the impact of an 8-month weight loss intervention induced by physical activity and nutrition on bone health in adolescents with obesity. The overall aim of this thesis was to examine the impact of a lifestyle weight loss intervention on the bone parameters in adolescents with obesity. Method: Sixty-five adolescents were recruited: 31 (6 males) adolescents with obesity in the weight loss intervention (age: 13.61 (1.27)), 23 normal weight (NW) adolescents (age: 15.90 (0.43)) and 11 (4 males) adolescents with obesity in another control group (14.0
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37

Yung, Koon-yu Samuel. "Effects of green tea on bone loss in mature ovariectomized rat." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23339846.

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38

Howie, Donald William. "The role of wear particles in prosthesis loosening /." Title page, contents and summary only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phh861.pdf.

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39

Martin, Chelsea Kathleen. "Mechanisms and Treatment of Bone Resorption in Models of Oral Squamous Cell Carcinoma." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1285015046.

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40

Peng, Songlin, and 彭松林. "Investigation of the cellular and molecular mechanisms for the dual effect of strontium on bone." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45585167.

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41

Davies, Emma Louise. "Heat shock proteins : interactions with bone and immune cells." Thesis, University of Chester, 2004. http://hdl.handle.net/10034/76182.

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Heat shock proteins (Hsps) are increasingly being seen as having roles other than those of intracellular molecular chaperones, particularly with regard to their potential to act as cytokines, and to stimulate the innate immune system. Hsps have also been found to promote bone resorption and osteoclast formation in vitro, although the mechanism has not been previously identified. The overall aims of this thesis were to determine whether Hsps could stimulate bone resorption by affecting the RANKL/OPG pathway, and to address the hypothesis that Hsps can act as a danger signal to the innate immune
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42

Symons, Anne L. "The dento-alveolar complex /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17714.pdf.

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43

Crawford, Ross William. "Focal femoral osteolysis in cemented total hip replacement." Thesis, University of Oxford, 2000. http://ora.ox.ac.uk/objects/uuid:67914dbd-6405-41a3-b4d6-6baeb8bbf0bf.

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As implant survival extends into the second and third decades focal osteolysis around cemented femoral components in total hip replacement is emerging as an important failure mechanism. Whilst the problem of focal osteolysis is well recognised, there are many aspects of its development which are poorly understood. The broad aim of this thesis is to try to provide some insights into how, why and where focal osteolysis develops around the cemented femoral component. There are broadly two sections to this thesis, chapters 2-5 present clinical and geometrical studies and chapters 6-10 a series of
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44

Mattila, P. (Pauli). "Dietary xylitol in the prevention of experimental osteoporosis:beneficial effects on bone resorption, structure and biomechanics." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:951425158X.

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Abstract Dietary xylitol supplementation increases bone calcium and phosphorus concentrations in healthy rats, as well as protects against the decrease of bone minerals and bone density during experimental osteoporosis. This suggests that dietary xylitol might have a favorable effect on the prevention of osteoporosis. However, before any conclusions can be drawn about the usefulness of a compound, studies including structural evaluation and biomechanical testing of bones must first be performed. Thus, the aim of the present study was to clarify whether dietary xylitol affects bone res
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45

Willey, Jeffrey S. "Radiation-induced osteoporosis bone quantity, architecture, and increased resorption following exposure to ionizing radiation /." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1211387053/.

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46

Maeda, Miki [Verfasser], and Eric [Akademischer Betreuer] Hesse. "Role of Tgif1 in osteoclast differentiation and bone resorption / Miki Maeda ; Betreuer: Eric Hesse." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1183262426/34.

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47

Antonioli, Corboz Véronique. "Effect of macrophage colony-stimulating factor on "in vitro" osteoclast generation and bone resorption /." Bern, 1993. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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48

Egger, Chantal Denise. "Evaluation of urinary pyridinoline excretion as a marker of bone resorption in the rat /." Bern : [s.n.], 1993. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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49

Frota, Nicolly Parente Ribeiro. "Effects of Tiludronate Administration as an Adjunctive to Mechanical Periodontal Treatment or not in Experimental Periodontitis in Rats." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10150.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Background and Objectives: The proven efficacy of bisphosphonates to inhibit the osteoclastic bone resorption has led to their use in the management of periodontal diseases. This dissertation, comprised by 2 manuscripts, aimed: (1) to histologically analyze the effects of systemic administration of Tiludronate (TIL) on ligature-induced periodontitis in rats; (2) to histologically analyze the effects of systemic administration of TIL as an adjunctive therapy to mechanical periodontal treatment on ligature-induced periodontitis in ra
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50

Cheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.

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[Truncated abstract] Osteoclasts are multinucleated giant cells responsible for the resorption of the mineralized bone matrix during the process of bone remodelling. During activation towards bone resorption, polarization of the osteoclast results in the formation of a unique plasma membrane, the ruffled border, the actual resorptive organelle of the osteoclast. Through this domain protons are actively pumped into the resorption lacuna creating an acidic microenvironment that favours the dissolution of the mineralized bone matrix. The polarised secretion of protons is carried out by the action
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