Relevant bibliographies by topics / Bone substitute

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Bone substitute'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 March 2023

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Journal articles on the topic "Bone substitute"

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Jhun, Jick Soo, Hui Suk Yun, Eui Kyun Park, and Hong In Shin. "Bone Repair Efficiency by Various Round Granular Bone Substitutes." Key Engineering Materials 493-494 (October 2011): 143–46. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.143.

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To improve the efficiency of osteogenic repair, we compared 3 types of round granular bone substitutes composed of hydroxyapatite (HA) in a single opened large pore covered by one or more thin shell structure, biphasic HA and tricalcium phosphate (TCP) in a compact granules with small uniform interconnected internal pores, and bioglass(BG) in a compact granules with hierarchical interconnected pores its bone repair efficiency by evaluation of cellular toxicity, cellular attachment and proliferation rate, and osteogenic supportive effect. They were nontoxic and revealed no noxious effect on cellular proliferation and osteoblastic differentiation. The cultured cells were most effectively proliferated on HA granular bone substitute surface. However, the bony repair of calvarial defects was most effective by BCP granular bone substitutes. The implanted BCP and HA granular bone substitutes showed excellent osteoconductive bone growth and favorable bone regeneration within 3 weeks compared to BG granular bone substitutes. All type granular bone substitutes were well incorporated into newly formed bone without foreign body reaction. Except for HA granular bone substitute, some implanted BG and BCP granular bone substitutes were partially resobed by TRAP positive multinucletated cells. These findings suggest that round granular biphasic calcium phosphate bone substitute structured with fully interconnected uniform sized internal pore might be a more promising bone substitute for small-sized none load-bearing bone defects.
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Yamada, M., T. Ueno, H. Minamikawa, N. Sato, F. Iwasa, N. Hori, and T. Ogawa. "N-acetyl Cysteine Alleviates Cytotoxicity of Bone Substitute." Journal of Dental Research 89, no. 4 (March 3, 2010): 411–16. http://dx.doi.org/10.1177/0022034510363243.

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Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20% of rat calvaria osteoblasts were viable when cultured on commercial deproteinized bovine bone particles for 24 hr, whereas this percentage doubled on bone substitute containing NAC. Intracellular ROS levels markedly increased on and under bone substitutes, which were reduced by prior addition of NAC to materials. NAC restored suppressed alkaline phosphatase activity in the bone substitute. Proinflammatory cytokine levels from human osteoblasts on the bone substitute decreased by one-third or more with addition of NAC. NAC alleviated cytotoxicity of the bone substitute to osteoblastic viability and function, implying enhanced bone regeneration around NAC-treated inorganic biomaterials.
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Jung, Ki-Jin, Swapan Kumar Sarkar, Woo-Jong Kim, Bo-Ram Kim, Jong-Seok Park, and Byong-Taek Lee. "Bone Regeneration by Multichannel Cylindrical Granular Bone Substitute for Regeneration of Bone in Cases of Tumor, Fracture, and Arthroplasty." International Journal of Environmental Research and Public Health 19, no. 14 (July 6, 2022): 8228. http://dx.doi.org/10.3390/ijerph19148228.

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In orthopedics, a number of synthetic bone substitutes are being used for the repair and regeneration of damaged or diseased bone. The nature of the bone substitutes determines the clinical outcome and its application for a range of orthopedic clinical conditions. In this study, we aimed to demonstrate the possible applications of multichannel granular bone substitutes in different types of orthopedic clinical conditions, including bone tumor, fracture, and bone defect with arthroplasty. A clinical investigation on a single patient for every specific type of disease was performed, and patient outcome was evaluated by physical and radiographic observation. Brief physical characterization of the granular bone substitute and in vivo animal model investigation were presented for a comprehensive understanding of the physical characteristics of the granules and of the performance of the bone substitute in a physiological environment, respectively. In all cases, the bone substitute stabilized the bone defect without any complications, and the defect regenerated slowly during the postoperative period. Gradual filling of the defect with the newly regenerated bone was confirmed by radiographic findings, and no adverse effects, such as osteolysis, graft dispersion, and non-union, were observed. Homogeneous bone formation was observed throughout the defect area, showing a three-dimensional bone regeneration. High-strength multichannel granules could be employed as versatile bone substitutes for the treatment of a wide range of orthopedic conditions.
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Bedini, Rossella, Deborah Meleo, and Raffaella Pecci. "3D Microtomography Characterization of Dental Implantology Bone Substitutes Used In Vivo." Key Engineering Materials 541 (February 2013): 97–113. http://dx.doi.org/10.4028/www.scientific.net/kem.541.97.

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After a short introduction to bone substitute biomaterials and X-ray microtomography, this article describes a research work carried out for in-vitro characterization of bone substitute biomaterials as well as for in-vivo investigation of human bone grafted with biomaterials. Three different bone substitute biomaterials have been analyzed in-vitro by means of 3D microtomographic technique, while human bone samples grafted with bone substitute biomaterials are investigated by 3D microtomography and histological techniques. 3D images of bone substitutes and human bone samples with biomaterials have been obtained, together with morphometric parameters, by microtomography . 2D histological images have also been obtained by traditional technique only for human bone samples with biomaterials. Compared to traditional histological analysis, 3D microtomography shows better results for investigating bone tissue and bone substitute biomaterial, and in a short time. Nevertheless, histological analysis remains the best technique for the observation of soft tissue and blood vessels.
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Martin-Piedra, Miguel-Angel, Belén Gironés-Camarasa, Antonio España-López, Ricardo Fernández-Valadés Gámez, Cristina Blanco-Elices, Ingrid Garzón, Miguel Alaminos, and Ricardo Fernández-Valadés. "Usefulness of a Nanostructured Fibrin-Agarose Bone Substitute in a Model of Severely Critical Mandible Bone Defect." Polymers 13, no. 22 (November 15, 2021): 3939. http://dx.doi.org/10.3390/polym13223939.

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Critical defects of the mandibular bone are very difficult to manage with currently available materials and technology. In the present work, we generated acellular and cellular substitutes for human bone by tissue engineering using nanostructured fibrin-agarose biomaterials, with and without adipose-tissue-derived mesenchymal stem cells differentiated to the osteogenic lineage using inductive media. Then, these substitutes were evaluated in an immunodeficient animal model of severely critical mandibular bone damage in order to assess the potential of the bioartificial tissues to enable bone regeneration. The results showed that the use of a cellular bone substitute was associated with a morpho-functional improvement of maxillofacial structures as compared to negative controls. Analysis of the defect site showed that none of the study groups fully succeeded in generating dense bone tissue at the regeneration area. However, the use of a cellular substitute was able to improve the density of the regenerated tissue (as determined via CT radiodensity) and form isolated islands of bone and cartilage. Histologically, the regenerated bone islands were comparable to control bone for alizarin red and versican staining, and superior to control bone for toluidine blue and osteocalcin in animals grafted with the cellular substitute. Although these results are preliminary, cellular fibrin-agarose bone substitutes show preliminary signs of usefulness in this animal model of severely critical mandibular bone defect.
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Bornert, Fabien, François Clauss, Guoqiang Hua, Ysia Idoux-Gillet, Laetitia Keller, Gabriel Fernandez De Grado, Damien Offner, et al. "Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics." Biomedicines 9, no. 8 (August 3, 2021): 952. http://dx.doi.org/10.3390/biomedicines9080952.

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One major limitation for the vascularization of bone substitutes used for filling is the presence of mineral blocks. The newly-formed blood vessels are stopped or have to circumvent the mineral blocks, resulting in inefficient delivery of oxygen and nutrients to the implant. This leads to necrosis within the implant and to poor engraftment of the bone substitute. The aim of the present study is to provide a bone substitute currently used in the clinic with suitably guided vascularization properties. This therapeutic hybrid bone filling, containing a mineral and a polymeric component, is fortified with pro-angiogenic smart nano-therapeutics that allow the release of angiogenic molecules. Our data showed that the improved vasculature within the implant promoted new bone formation and that the newly-formed bone swapped the mineral blocks of the bone substitutes much more efficiently than in non-functionalized bone substitutes. Therefore, we demonstrated that our therapeutic bone substitute is an advanced therapeutical medicinal product, with great potential to recuperate and guide vascularization that is stopped by mineral blocks, and can improve the regeneration of critical-sized bone defects. We have also elucidated the mechanism to understand how the newly-formed vessels can no longer encounter mineral blocks and pursue their course of vasculature, giving our advanced therapeutical bone filling great potential to be used in many applications, by combining filling and nano-regenerative medicine that currently fall short because of problems related to the lack of oxygen and nutrients.
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Freischmidt, Holger, Jonas Armbruster, Emma Bonner, Thorsten Guehring, Dennis Nurjadi, Maren Bechberger, Robert Sonntag, Gerhard Schmidmaier, Paul Alfred Grützner, and Lars Helbig. "Systemic Administration of PTH Supports Vascularization in Segmental Bone Defects Filled with Ceramic-Based Bone Graft Substitute." Cells 10, no. 8 (August 11, 2021): 2058. http://dx.doi.org/10.3390/cells10082058.

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Non-unions continue to present a challenge to trauma surgeons, as current treatment options are limited, duration of treatment is long, and the outcome often unsatisfactory. Additionally, standard treatment with autologous bone grafts is associated with comorbidity at the donor site. Therefore, alternatives to autologous bone grafts and further therapeutic strategies to improve on the outcome and reduce cost for care providers are desirable. In this study in Sprague–Dawley rats we employed a recently established sequential defect model, which provides a platform to test new potential therapeutic strategies on non-unions while gaining mechanistic insight into their actions. The effects of a combinatorial treatment of a bone graft substitute (HACaS+G) implantation and systemic PTH administration was assessed by µ-CT, histological analysis, and bio-mechanical testing and compared to monotreatment and controls. Although neither PTH alone nor the combination of a bone graft substitute and PTH led to the formation of a stable union, our data demonstrate a clear osteoinductive and osteoconductive effect of the bone graft substitute. Additionally, PTH administration was shown to induce vascularization, both as a single adjuvant treatment and in combination with the bone graft substitute. Thus, systemic PTH administration is a potential synergistic co-treatment to bone graft substitutes.
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Titsinides, Savvas, Theodore Karatzas, Despoina Perrea, Efstathios Eleftheriadis, Leonidas Podaropoulos, Demos Kalyvas, Christos Katopodis, and George Agrogiannis. "Osseous Healing in Surgically Prepared Bone Defects Using Different Grafting Materials: An Experimental Study in Pigs." Dentistry Journal 8, no. 1 (January 9, 2020): 7. http://dx.doi.org/10.3390/dj8010007.

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Regeneration of large jaw bone defects still remains a clinical challenge. To avoid incomplete bone repair, bone grafts have been advocated to support the healing process. This study comparatively evaluated new bone formation among a synthetic graft substitute, a human bone derivative, and a bovine xenograft. Materials were placed in 3 out of the 4 bone cavities, while 1 deficit was left empty, serving as a control, in mono-cortical defects, surgically prepared in the porcine calvaria bone. Animals were randomized in 2 groups and euthanized at 8 and 12 weeks. Harvested tissue specimens were qualitatively evaluated by histology. New bone formation was quantitatively measured by histomorphometry. Maximum new bone formation was noticed in defects grafted with beta-tricalcium phosphate b-TCP compared to the other bone substitutes, at 8 and 12 weeks post-surgery. Bovine and human allograft induced less new bone formation compared to empty bone cavity. Histologic analysis revealed that b-TCP was absorbed and substituted significantly, while bovine and human allograft was maintained almost intact in close proximity with new bone. Based on our findings, higher new bone formation was detected in defects filled with b-TCP when compared to bovine and human graft substitutes.
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Chan, Kam-Kong, Chia-Hsien Chen, Lien-Chen Wu, Yi-Jie Kuo, Chun-Jen Liao, and Chang-Jung Chiang. "IN VIVO EVALUATION OF A NEW β-TRICALCIUM PHOSPHATE BONE SUBSTITUTE IN A RABBIT FEMUR DEFECT MODEL." Biomedical Engineering: Applications, Basis and Communications 27, no. 03 (May 28, 2015): 1550028. http://dx.doi.org/10.4015/s1016237215500283.

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Calcium phosphate ceramics, of a similar composition to that of mineral bone, and which possess the properties of bioactivity and osteoconductivity, have been widely used as substitutes for bone graft in orthopedic, plastic and craniofacial surgeries. A synthetic β-tricalcium phosphate, Osteocera™, a recently developed bone graft substitute, has been used in this study. To evaluate the affinity and efficacy of Osteocera™ as bone defect implant, we used a New Zealand white rabbit femur defect model to test the osteoconductivity of this new bone substitute. Alternative commercially available bone substitutes, Triosite® and ProOsteon500, were used as the control materials. These three bone substitutes show good biocompatibility, and no abnormal inflammation either infection was seen at the implantation sites. In the histological and histomorphometric images, newly formed bone grew into the peripheral pores in the bone substitutes. After six months implantation, the volume of bone formation was found to be 20.5 ± 5.2%, 29.8 ± 6.5% and 75.5 ± 4.9% of the potential total cavity offered by ProOsteon500, Triosite® and Osteocera™, respectively. The newly formed bone area within the femur defect section for Osteocera™ was significantly larger than ProOsteon500 and Triosite®. We concluded that Osteocera™ shows better bioresorbability, biocompatibility and osteoconductivity in the rabbit femur defect model.
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Cho, Tae Joon, and Ki Seok Lee. "Bone Graft Substitute." Journal of the Korean Fracture Society 19, no. 1 (2006): 109. http://dx.doi.org/10.12671/jkfs.2006.19.1.109.

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Dissertations / Theses on the topic "Bone substitute"

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Guimarães, Maria Rosa Felix de Sousa Gomide [UNESP]. "Reparo ósseo de defeitos cirúrgicos críticos preenchidos ou não com ß – fosfato tricálcio (RTR® – Septodont): estudo histológico e histométrico em tíbias de ratos." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/144731.

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Objetivos: Analisar histologicamente e histometricamente o efeito do RTR® em defeitos ósseos cirúrgicos críticos em tíbias de ratos no processo de reparo ósseo. Materiais e Métodos: Defeitos ósseos críticos foram criados nas tíbias de 32 ratos Wistar divididos em dois grupos: Grupo Coágulo e Grupo RTR®. Após o período experimental de 30 e 90 dias, os animais foram sacrificados e as peças incluídas em parafina, cortadas e coradas com hematoxilina e eosina. Dois parâmetros foram analisados: a área óssea total neoformada (AON) e a área óssea da cortical neoformada (ACN). A análise estatística foi realizada nos dois períodos de observação pela análise de variância (ANOVA) e pelo Teste de Tukey. Resultados: Todos os grupos demonstraram reparo ósseo superior quando comparados ao Grupo Coágulo 30 dias nos dois parâmetros analisados. O Grupo RTR®, em 30 e 90 dias, apresentou reparo da cortical óssea e formações de tecido ósseo na região central do defeito maior do que no Grupo Coágulo de 90 dias, que apresentou reparo parcial da cortical óssea e poucas formações de tecido ósseo na região do defeito (p<0,05). Conclusões: O RTR® favoreceu a neoformação óssea no modelo experimental adotado podendo ser indicado em casos de cavidades ósseas de tamanho crítico.
Objectives: To analyze histologically and histometrically the effect of RTR® on critical surgical bone defects in rat tibiae in the bone repair process. Materials and Methods: Critical bone defects were created in the tibia of 32 Wistar rats divided into two groups: Clot Group and RTR® Group. After the experimental period of 30 and 90 days, the animals were sacrificed and the paraffin embedded pieces were cut and stained with hematoxylin and eosin. Two parameters were analyzed: total neoformed bone area (AON) and bone area of neoformed cortical (ACN). Statistical analysis was performed in the two observation periods by analysis of variance (ANOVA) and Tukey's test. Results: All groups demonstrated superior bone repair when compared to the Clot Group 30 days in the two analyzed parameters. The RTR® Group, in 30 and 90 days, presented repair of the cortical bone and bone tissue formations in the central region of the defect greater than in the 90-day Clot Group, which presented partial repair of the cortical bone and few bone tissue formations in the region of the defect (p <0.05). Conclusions: The RTR® favored the bone neoformation in the adopted experimental model and can be indicated in cases of bone of critical size.
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Samizadeh, S. "Bone formation on calcium phosphate bone substitute materials." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19891/.

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A large number of bone substitute materials are available; for which some authors claim osteoconductivity and some osteoinductivity. In order to rank these materials an in vivo analysis was carried out. These materials were chosen based on their availability and claimed mode of action. Silicon substituted Hydroxyapatite (SiHA), Hydroxyapatite (HA), Resorbable Calcium Phosphate Silicon, Skelite [siliconstabilized tricalcium phosphate-based bone substitute], Pro Osteon 500R [coralline HA], BiIonic [Yttrium stabilized SiHA] and two non-calcium phosphate, Dimeneralised Bone Matrix (DBM) based biomaterials: Accell Connexus DBM putty and Grafton crunch DBM were implanted in sheep femoral condyle defects for 6 weeks. Implanted calcium phosphate (CaP) based biomaterials demonstrated superior bone formation in comparison with the DBM samples. Silicon within CaPs increased the rate of bone formation in vivo. Silicon substituted HA showed increased proliferation rate (P<0.05) of human marrow stromal cells compared to pure HA in vitro. Expression of osteoblastic marker genes RUNX2, Osterix and Osteopontin within the hMSCs indicated the differentiation of preosteoblasts into osteoblasts, and osteogenic development on both HA and SiHA. Expression of osteocalcin and bone sialoprotein genes on HA and SiHA samples indicated the activation of mineralisation process. Differentiation of hMSCs into osteoblasts in vitro suggested a role in promotion of osteoinduction by both HA and SiHA. Implantation of porous SiHA and HA in paraspinous muscle of sheep, exhibited new bone formation through osteoinduction. SiHA indicated significantly higher new bone formation (P<0.01) compared to HA. SiHA and HA biomaterials with higher strut porosity (30%) indicated greater bone formation (P<0.05). In conclusion, CaP based biomaterials demonstrate superior bone formation in comparison with DBM biomaterials. Silicon substitution within HA enhances the cellular activity of hMSCs. Osteoinduction was greatest on SiHA with higher strut porosity. This result is believed to be due to a combination of the effect of interconnected porosity and chemical composition of the bone substitute.
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Öberg, Sven. "Bone healing after implantation of bone substitute materials : experimental studies in estrogen deficiency /." Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138.

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Bonardi, João Paulo. "Estudo comparativo entre o ChronOs® e o Bio-Oss® em procedimentos de elevação da membrana sinusal em seios maxilares de humanos : análise histométrica e imunoistoquímica /." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/148947.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Objetivos: Comparar através de análise hitométrica e imunoistoquimica o comportamento do ChronOs® (β-TCP) e do Bio-Oss® (Osso bovino inorgânico ) puros e misturados ao osso autógeno na proporção 1:1 em seios maxilares de humanos. Metodologia: 30 pacientes foram convidados para participar deste trabalho, resultando em 30 seios enxertados com osso autógeno puro (grupo A (controle)), ChronOs® puro (grupo C), ChronOs® em adição de osso autógeno na proporção 1:1(grupo CA), Bio-Oss® puro (grupo B) e Bio-Oss® em adição de osso autógeno na proporção de 1:1 (grupo BA), onde foram realizadas biopsias 6 meses após a realização desses enxertos e analisadas através de histometria (analisadas através do software ImageJ) e imunoistoquimica (RUNX2, VEGF e Osteocalcina). Os resultados foram tabulados, o teste de Shapiro-Wilk foi aplicado para avaliação da normalidade, em seguida foram aplicado os testes Kruskal-Wallis e Anova 1 fator para os dados paramétricos e não paramétricos sucetivamente e o teste de Tukey como pós teste. Resultados: Para neoformação óssea o grupo A foi maior que os grupos B e BA e o grupo CA foi maior que o grupo BA (p<0,05). Para os remanescentes de biomateriais o grupo BA apresentou um número maior que os grupos Chronos C, CA e A (p<0,05). Para tecido mole o grupo C foi maior que o grupo B (p<0,05). O resultado das imunomarcações mostrou marcação fraca para RUNX 2 nos grupos A, C, B e BA e marcação moderada para o grupo CA. Marcação intensa para VEGF nos grupos B e CA, moderada nos grupos A e C e fraca no grupo BA. Para a Osteocalcina houve uma marcação intensa em todos os grupos. Conclusão: Conclui-se que o Chronos puro ou misturado apresentam comportamento mais próximo ao osso autógeno em termos de quantidade de tecido ósseo neoformado e remanescentes de biomateriais que o Bio Oss puro ou associado ao osso autógeno.
Objectives: To compare the performance of ChronOs® (β-TCP) and Bio-Oss® (Inorganic bovine bone) pure and mixed with autogenous bone in a 1: 1 ratio in maxillary sinuses of humans through histometric and immunohistochemical analysis. Metodology: 30 patients were invited to participate of this study, resulting in 30 grafted sinuses with pure autogenous bone (group A (control)), pure ChronOs® (group C), ChronOs® in addition 1: 1 autogenous bone (group CA), pure Bio-Oss®(group B) and Bio-Oss® in addition1: 1 (group BA), which biopsies were performed 6 months after the grafting and analyzed by histology (analyzed using ImageJ software) and immunohistochemistry (RUNX2, VEGF and Osteocalcin). The results were tabulated, the Shapiro-Wilk test was applied to evaluate the normality, then the Kruskal-Wallis and Anova 1 tests were applied for the parametric and non-parametric data and Tukey test as post test was applied. Results: The group A was higher than B and BA groups, and the group CA was higher than the BA group (P <0.05). For the remainder of biomaterials, BA group presented a higher number than Chronos C, CA and A groups (P <0.05). For soft tissue, group C was greater than group B (P <0.05). The immunolabeling results showed poor labeling for RUNX 2 in groups A, C, B and BA and moderate labeling for CA group. Intense labeling for VEGF in B and CA groups, moderate in groups A and C and weak in BA group. For Osteocalcin, there was an intense marking in all groups. Conclusion: It was concluded that pure or mixed Chronos present behavior closer to the autogenous bone in terms of amount of neoformed bone tissue and biomaterial remnants than the pure or mixed Bio Oss.
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Simpson, Rebecca Louise. "Design of a bone substitute material." Thesis, Imperial College London, 2006. http://hdl.handle.net/10044/1/11534.

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Al-Bader, Yousef A. "Development of a piezoelectric bone substitute material." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249905.

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Hilal, M. K. "Development of a high strength bioactive bone substitute." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267175.

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Öberg, Sven. "Bone Healing after implantation of bone substitute materials. Experimental studies in estrogen deficiency." Doctoral thesis, Umeå University, Odontology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138.

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Bone formation and bone healing were studied in the mandible, tibia and skull bones in adult, healthy and estrogen deficient rabbits implanted with different bone substitutes.

In the first study an evaluation of the differences in bone regeneration in and around solid (Alveograf *) and porous hydroxyapatite (Interpore 200*) was undertaken. The implant material was placed into experimentally made bone defects and in half of the defects hydroxyapatite was mixed with a fibrin sealant (Tisseel *). The material alone or mixed with Tisseel was also placed subperiostally in the mandible. The observation time was six month. No difference in bone regeneration was found between solid or porous hydroxyapatite granulas and the addition of Tisseel* did not seem to disturb the bone healing process. The implant material placed subperiostally did not induce bone formation nor did it provoke any bone resorption. The addition of Tisseel made the implant material much easier to handle and retain in the tissue during surgery.

Bone healing around hydroxyapatite implants was also evaluated in the second study. Experimental cavities in the mandible and tibia were filled with hydroxyapatite in granules or blocks (Interpore 200*) but now with or without autolyzed, antigen-extracted, allogeneic bone (AAA). Also in this study Tisseel* was used to facilitate the handling of the material. All cavities implanted with AAA-bone, regardless of the combination with hydroxyapatite or Tisseel, demonstrated excessive bone formation resembling exostosis formation. Thus, hydroxyapatite, both as granules and blocks, can be successfully combined with AAA bone utilizing the bone inductive capacity of AAA bone.

The same model was used to study the healing in ovariectomized animals in the third study. Bone cavities were implanted with or without AAA bone and left to heal. The results indicate that the osteoinductive capacity of AAA bone is in operation also in animals deprived of a normal estrogen production.

The effect of using AAA bone prior to implant insertion was studied in paper four. The bone-implant contact was significant higher when AAA bone had been used. The implant stability did not seem to be affected.

In paper five defects were made in skull and tibial bone in estrogen deficient animals. The deficiency of estrogen was confirmed through blood analysis, the decrease in the weight of uterus and bone mineral density. The whole body scanning with DEXA showed that the ovariectomized animals developed osteopenia. Various degree of bone formation was seen in the defects due to the influence of the bone inductive substance AAA bone.

The studies indicate that a conductive material like hydroxyapatite in granules or blocks could be useful in oral reconstructive surgery. The combination with AAA bone enhanced the bone formation in calvarial and tibial bone in healthy and estrogen deficient animals. Tisseel* could be used to facilitate handling and retention of the material in the intended position during the healing process without negative effects.

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Alfayez, Eman Saud. "Synergizing angiogenesis and osteogenesis in a smart bone substitute." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/synergizing-angiogenesis-and-osteogenesis-in-a-smart-bone-substitute(ad38b2b9-e1e3-42ce-88a0-91a764bc14e6).html.

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The major aim of this project was to develop a biologically active bone scaffold that could induce vascularization in critical-size defects (CSD) and hence bone formation. In this study, functionalization of three-dimensional (3D) printed biphasic calcium phosphate (BCP) scaffolds was investigated. The first functionalization approach involved printing scaffolds with two different pore geometries and sizes; square (400μ) and round (800μ). The second was by coating scaffolds with DAR16-II; a self-assembly peptide that forms a hydrogel nanostructure mimicking extracellular matrix (ECM). A rabbit model was used to study these functionalization methods; square and round pore scaffolds with and without DAR16-II coating were implanted into experimental rabbit calvaria bone CSD defects. After 8 weeks, animals were killed and tissue was processed for histomorphometric analysis. Histological evaluation showed that bone formation was pore size and geometry independent while DAR16-II was successful in inducing bone formation compared to non-coated scaffolds. The following in vitro studies aimed towards understanding the basic cell response that enhanced bone formation in vivo. Human mesenchymal stem cells (MSCs) were used to identify the osteogenic potential of DAR16-II. Molecular analysis and mineralization staining showed that DAR16-II lacks osteoinductive properties. However, DAR16-II preserved cell viability when used as a BCP coating in vitro. In addition, DAR16-II exhibited angiogenic potential upon culturing with human umbilical vein endothelial cells (HUVECs) in vitro. DAR16-II induced the spreading of endothelial cells, activation and tubular-structure formation. Angiogenesis Real time-2 (RT2) polymerase chain reaction (PCR) array was used for gene expression analysis and showed that DAR16-II angiogenic effect was regulated by overexpression of endoglin (ENG or CD105), a clade E member of the serine protease inhibitor-1 (SERPIN-1) and β-Actin (ACTB) and down-regulation of VEGF receptor I (Flt1) and VEGF receptor II (KDR) Flt1. Furthermore, DAR16-II enhanced attachment of monocyte THP-1 cells. Results have demonstrated that DAR16-II add a proactive factor to BCP scaffolds. The proposed functionalization methodology increases the potential of enhancing vascularization and bone formation within ceramic scaffolds.
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Abbah, Sunny Akogwu. "Towards an injectable bone graft substitute: evaluation of sodium alginate microcapsules for bone tissueengineering." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B39329951.

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Books on the topic "Bone substitute"

1

Bone substitute biomaterials. Cambridge, UK: Woodhead Publishing is an imprint of Elsevier, 2014.

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Isaksson, Sten. Aspects of bone healing and bone substitute incorporation: An experimental study in rabbit skull bone defects. Malmö, Sweden: Department of Oral Surgery and Oral Medicine, Lund University, Centre for Oral Health Sciences, 1992.

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Mauro, Frank Armand. Assessment of biodegradable calcium polyphosphate for bone substitute application in the healing of the rat calvarium. [Toronto: University of Toronto, Faculty of Dentistry], 1999.

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B, Habal Mutaz, and Reddi A. H. 1942-, eds. Bone grafts & bone substitutes. Philadelphia: Saunders, 1992.

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Katthagen, Bernd-Dietrich. Bone Regeneration with Bone Substitutes. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71827-4.

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Laurencin, CT, ed. Bone Graft Substitutes. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2003. http://dx.doi.org/10.1520/mono6-eb.

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International, ASTM, ed. Bone graft substitutes and bone regenerative engineering. 2nd ed. West Conshohocken, PA: ASTM International, 2014.

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Aziz, Nather, ed. Bone grafts and bone substitutes: Basic science and clinical applications. Hackensack, N.J: World Scientific, 2005.

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R, Urist Marshall, O'Connor Brian T, and Burwell R. Geoffrey, eds. Bone grafts, derivatives, and substitutes. Oxford: Butterworth-Heinemann, 1994.

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Laurencin, Cato T., and Tao Jiang, eds. Bone Graft Substitutes and Bone Regenerative Engineering, 2nd Edition. 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959: ASTM International, 2014. http://dx.doi.org/10.1520/mono6-2nd-eb.

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Book chapters on the topic "Bone substitute"

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Singh, Harshpal, and Allan D. Levi. "Bone Graft and Bone Substitute Biology." In Spine Surgery Basics, 147–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34126-7_10.

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Baroth, Serge, Xavier Bourges, Borhane H. Fellah, and Guy Daculsi. "Radiopaque Strategy for Bone Injectable Substitute." In Bioceramics 20, 39–42. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-457-x.39.

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Long, Marc, Charles Martin, and Mike Cooper. "Confined Compression of Bone Substitute Granules." In Bioceramics 17, 361–64. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.361.

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Korbelář, P. "The Promising Application of Special Plastics as a Substitute for Bone Tissue." In Bone Transplantation, 349–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83571-1_80.

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Suzuki, Osamu, and Takahisa Anada. "Highly Biodegradable Bone Substitute Materials with OCP." In Interface Oral Health Science 2011, 321–26. Tokyo: Springer Japan, 2012. http://dx.doi.org/10.1007/978-4-431-54070-0_96.

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Alonso, Nivaldo, and Julia Amundson. "Bone Substitute: Alveolar Bone Grafting (ABG) with rhBMP-2 (Recombinant Bone Morphogenic Protein-2)." In Cleft Lip and Palate Treatment, 263–68. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63290-2_17.

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Grgurevic, Lovorka, Igor Erjavec, Ivo Dumic-Cule, Tatjana Bordukalo-Niksic, Martina Pauk, Vladimir Trkulja, Drazen Maticic, et al. "Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction." In Bone Morphogenetic Proteins: Systems Biology Regulators, 215–28. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47507-3_9.

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Khoshakhlagh, P., F. Moztarzadeh, S. M. Rabiee, R. Moradi, P. Heidari, R. Ravarian, and S. Amanpour. "Bioglass/Chitosan Composite as a New Bone Substitute." In Advances in Bioceramics and Porous Ceramics III, 39–46. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470944028.ch4.

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Klinkenberg, E. D., Hans Georg Neumann, Ulrike Bulnheim, and Joachim Rychly. "The New Art of Bone Graft Substitute Design." In Key Engineering Materials, 959–62. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-422-7.959.

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Lange, Thomas A. "Ceramic Tricalcium Phosphate As a Bone-Graft Substitute for Benign Bone Tumors." In New Developments for Limb Salvage in Musculoskeletal Tumors, 675–80. Tokyo: Springer Japan, 1989. http://dx.doi.org/10.1007/978-4-431-68072-7_97.

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Conference papers on the topic "Bone substitute"

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James, Thomas P., and Brendan A. Andrade. "Is Synthetic Composite Bone a Substitute for Natural Bone in Screw Bending Tests?" In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65498.

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Composite replica bones have been used extensively for biomechanical studies. These studies normally rely upon the overall tensile, compressive, and bending strength of large replica bones, such as the tibia and femur. In this study, highly localized behavior of composite bone was scrutinized by examining the material’s response to cortical screws in bending. Of interest was localized deformation of the composite material as compared to the response of natural bone under similar loading conditions. Cortical screw deflection in a laminated composite bone was compared to deflection in a bovine bone under quasi-static loading. The laminated composite bone consisted of short glass fiber reinforced epoxy as a cortical bone substitute, while polyurethane foam was used as a cancellous bone substitute. A new laser projection method was used to make comparative measurements of the slope of the screw head near to the applied load. Initial results indicate that composite bone is a reliable substitute for natural bone in quasi-static studies of cortical screw deflection.
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Rabiee, Sayed Mahmood. "Porous tricalcium phosphate scaffold for bone substitute." In 2011 1st Middle East Conference on Biomedical Engineering (MECBME). IEEE, 2011. http://dx.doi.org/10.1109/mecbme.2011.5752066.

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Qiao, XiangChen, Stephen Russel, Xuebin Yang, and David Wood. "Compositional selection of electrospun composites for bone substitute." In 2009 IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. http://dx.doi.org/10.1109/nebc.2009.4967783.

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Shah, Rushita, Nabanita Saha, Takeshi Kitano, and Petr Saha. "Mineralized polymer composites as biogenic bone substitute material." In PROCEEDINGS OF PPS-30: The 30th International Conference of the Polymer Processing Society – Conference Papers. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4918447.

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Yuan Hua, Chen Ning, Lu Xiaoying, Zheng Buzhong, Cui Wei, and Song Xiaoling. "Natural hydroxyapatite/chitosan composite for bone substitute materials." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1615568.

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Haddock, Sean M., Jack C. Debes, and Tony M. Keaveny. "Structure-Function Relationships for a Coralline Hydroxyapatite Bone Substitute." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0163.

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Abstract Coralline hydroxyapalite (Pro-Osteon 500, Interpore International, Irvine, CA) is an artificial bone substitute that has been approved by the FDA since 1993. Despite previous in vitro and animal studies on the mechanical behavior of coralline hydroxyapatite [1–3], its mechanical properties are not well understood. Further, the relationship between the microstructure and mechanical properties of coralline hydroxyapatite is unknown. Knowledge of this relationship is important in determining the optimal clinical use of this bone substitute.
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Hollensteiner, Marianne, Markus Samrykit, Michael Hess, David Fuerst, Benjamin Esterer, and Andreas Schrempf. "Inexpensive bone cement substitute for vertebral cement augmentation training." In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2016. http://dx.doi.org/10.1109/embc.2016.7591166.

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Sari, Novita, Alfian Pramudita Putra, Siswanto, Muhammad Fajar Faliasthiunus Pradipta, and Dyah Hikmawati. "Hydroxyapatite-gelatin-HPMC composite as injectable bone substitute with alendronate variation for osteoporotic bone." In THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0034044.

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Küpper, K., B. Bräuer, A. Magener, and D. Böger. "Early-adult-onset osteomyelitis of the frontal bone and Bioverit® bone substitute-based reconstruction." In Abstract- und Posterband – 91. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Welche Qualität macht den Unterschied. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1711364.

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Wu, Hera, and Shuting Lei. "A Review of Bone Graft Substitutes Made From HA-Polymer Composite Scaffolds and Fabrication Potential With Laser-Based Additive Manufacturing Processes." In ASME 2015 International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/msec2015-9366.

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Hydroxyapatite, a bioactive ceramic, has been combined with biodegradable polymers to create composite three-dimensional interconnected porous scaffolds for bone graft substitutes. The materials and fabrication methods of these composite scaffolds are reviewed. The resulting mechanical and biological properties of scaffolds produced from the combination of certain materials and fabrication methods are analyzed. Requirements for a bone graft substitute and third generation scaffolds with the addition of osteoinductive and osteogenic features to composite scaffolds including biomolecule delivery and cell seeding are also introduced. Finally, the benefits of using additive manufacturing technologies to enable high level of control over the design of interconnected pore structure are discussed.
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Reports on the topic "Bone substitute"

1

Meza-Mauricio, Jonathan, Camila Pinheiro Furquim, Marlon Marx Hilariano Maximiano, Leonardo Delfino dos Reis, Gerardo Mendoza-Azpur, Francisco Wilker Mustafa Gomes Muniz, Giulio Rasperini, and Marcelo Faveri. How Efficacious is the Combination of Substitute Bone Graft with Autogenous Bone Graft in Comparison with Substitute Bone Graft Alone in the horizontal bone gain? A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0109.

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Meza-Mauricio, Jonathan, Camila Pinheiro Furquim, Leornado Delfino Dos Reis, Gerardo Mendoza-Azpur, Wilker Mustafa Gomes Muniz, Giulio Rasperini, and Marcelo Faveri. How Efficacious is the Association of Substitute Bone Graft with Autogenous Bone Graft in Comparison with Bone Graft Alone? A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2021. http://dx.doi.org/10.37766/inplasy2021.7.0081.

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Bush, Joshua. Degradable Bone Graft Substitute for Effective Delivery of Multiple Growth Factors in the Treatment of Nonunion Fractures. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada567964.

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Bush, Joshua. Degradable Bone Graft Substitute for Effective Delivery of Multiple Growth Factors in the Treatment of Nonunion Fractures. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada559323.

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Patrikov, Kircho, Svetoslav A. Slavchev, Georgi P. Georgiev, and Boyan Hristov. Synthetic Bone Substitutes in the Treatment of Giant Cell Tumour of Bone. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, June 2020. http://dx.doi.org/10.7546/crabs.2020.06.16.

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